piper

Summary

Summary: A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.

Top Publications

  1. ncbi Antidiabetic activities of aqueous and ethanolic extracts of Piper betle leaves in rats
    L S R Arambewela
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo 7, Sri Lanka
    J Ethnopharmacol 102:239-45. 2005
  2. ncbi Antioxidant, anti-TB activities, phenolic and amide contents of standardised extracts of Piper sarmentosum Roxb
    K Hussain
    School of Pharmaceutical Science, Universiti Sains Malaysia, Minden Campus Pulau Penang, Malaysia
    Nat Prod Res 23:238-49. 2009
  3. ncbi Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
    E S Sunila
    Amala Cancer Research Centre, Amalanagar, Thrissur 680 553, Kerala, India
    J Ethnopharmacol 90:339-46. 2004
  4. doi Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens
    Michele Cristina Vendrametto
    Programa de Pós Graduação em Ciências Farmacêuticas, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo 5790, Parana, Brazil
    Parasitol Int 59:154-8. 2010
  5. doi Schistosoma mansoni: In vitro schistosomicidal activity of piplartine
    Josué de Moraes
    Laboratorio de Parasitologia, Instituto Butantan, Sao Paulo, Brazil
    Exp Parasitol 127:357-64. 2011
  6. ncbi The tumorigenic characteristics of lime-piper betel quid-transformed JB6 cells
    Ming Hsun Lin
    Institute of Biochemistry of the College of Medicine, Chung Shan Medical University, No 110, Sec 1, Chien Kuo North Road, 402 Taichung, Taiwan
    Arch Toxicol 78:167-73. 2004
  7. doi Antimalarial activity of methanolic leaf extract of Piper betle L
    Abdulelah H Al-Adhroey
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 16:107-18. 2011
  8. ncbi High-frequency plant regeneration through cyclic secondary somatic embryogenesis in black pepper (Piper nigrum L.)
    R Ramakrishnan Nair
    Indian Institute of Spices Research, Calicut, 673012, Kerala, India
    Plant Cell Rep 24:699-707. 2006
  9. ncbi In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper
    D P Bezerra
    Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceara, Fortaleza, Brasil
    Braz J Med Biol Res 39:801-7. 2006
  10. ncbi Activity of neolignans isolated from Piper regnellii (MIQ.) C. DC. var. pallescens (C. DC.) YUNCK against Trypanosoma cruzi
    Patrícia Shima Luize
    Mestranda do Programa de Pós graduação em Ciências Farmacêuticas, Parana, Brazil
    Biol Pharm Bull 29:2126-30. 2006

Detail Information

Publications252 found, 100 shown here

  1. ncbi Antidiabetic activities of aqueous and ethanolic extracts of Piper betle leaves in rats
    L S R Arambewela
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo 7, Sri Lanka
    J Ethnopharmacol 102:239-45. 2005
    Leaves of Piper betle (Piperaceae) possess several bioactivities and are used in traditional medicinal systems. However, its antidiabetic activity has not been scientifically investigated so far...
  2. ncbi Antioxidant, anti-TB activities, phenolic and amide contents of standardised extracts of Piper sarmentosum Roxb
    K Hussain
    School of Pharmaceutical Science, Universiti Sains Malaysia, Minden Campus Pulau Penang, Malaysia
    Nat Prod Res 23:238-49. 2009
    Ethanol and aqueous extracts of the different parts of Piper sarmentosum were analysed by HPLC for marker compounds to standardise these extracts...
  3. ncbi Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
    E S Sunila
    Amala Cancer Research Centre, Amalanagar, Thrissur 680 553, Kerala, India
    J Ethnopharmacol 90:339-46. 2004
    Alcoholic extract of the fruits of the plant Piper longum and its component piperine was studied for their immunomodulatory and antitumor activity...
  4. doi Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens
    Michele Cristina Vendrametto
    Programa de Pós Graduação em Ciências Farmacêuticas, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo 5790, Parana, Brazil
    Parasitol Int 59:154-8. 2010
    ..Here we investigated the antileishmanial activity of eupomatenoid-5, a neolignan isolated from leaves of Piper regnellii var. pallescens...
  5. doi Schistosoma mansoni: In vitro schistosomicidal activity of piplartine
    Josué de Moraes
    Laboratorio de Parasitologia, Instituto Butantan, Sao Paulo, Brazil
    Exp Parasitol 127:357-64. 2011
    ..Here, we report the in vitro effect of piplartine, an amide isolated from Piper tuberculatum (Piperaceae), on Schistosoma mansoni adult worms. A piplartine concentration of 15...
  6. ncbi The tumorigenic characteristics of lime-piper betel quid-transformed JB6 cells
    Ming Hsun Lin
    Institute of Biochemistry of the College of Medicine, Chung Shan Medical University, No 110, Sec 1, Chien Kuo North Road, 402 Taichung, Taiwan
    Arch Toxicol 78:167-73. 2004
    ..In this study, the tumor-promoting neoplastic transformation effect of Lime-Piper betel quid (LPB) was examined on JB6 cells. The treatment of LPB at a high dose (1...
  7. doi Antimalarial activity of methanolic leaf extract of Piper betle L
    Abdulelah H Al-Adhroey
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 16:107-18. 2011
    ..The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) ..
  8. ncbi High-frequency plant regeneration through cyclic secondary somatic embryogenesis in black pepper (Piper nigrum L.)
    R Ramakrishnan Nair
    Indian Institute of Spices Research, Calicut, 673012, Kerala, India
    Plant Cell Rep 24:699-707. 2006
    A high-frequency plantlet regeneration protocol was developed for black pepper (Piper nigrum L.) through cyclic secondary somatic embryogenesis...
  9. ncbi In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper
    D P Bezerra
    Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceara, Fortaleza, Brasil
    Braz J Med Biol Res 39:801-7. 2006
    ..and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines...
  10. ncbi Activity of neolignans isolated from Piper regnellii (MIQ.) C. DC. var. pallescens (C. DC.) YUNCK against Trypanosoma cruzi
    Patrícia Shima Luize
    Mestranda do Programa de Pós graduação em Ciências Farmacêuticas, Parana, Brazil
    Biol Pharm Bull 29:2126-30. 2006
    The in vitro antiproliferative effects of 4 neolignans purified from the ethyl-acetate extract from leaves of Piper regnellii (MIQ.) C. DC. var. pallescens (C. DC.) YUNCK against Trypanosoma cruzi were investigated...
  11. ncbi Antimicrobial effects of Boesenbergia pandurata and Piper sarmentosum leaf extracts on planktonic cells and biofilm of oral pathogens
    Suwimol Taweechaisupapong
    Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand
    Pak J Pharm Sci 23:224-31. 2010
    ..this study aimed at determining the effects of oil and 95% ethanol extracts of Boesenbergia pandurata rhizomes and Piper sarmentosum leaf against four oral pathogens which were Streptococcus mutans, Lactobacillus sp...
  12. ncbi Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum
    Lianet Monzote
    Departamento de Parasitologia, Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba
    Mem Inst Oswaldo Cruz 105:168-73. 2010
    ..In this paper, we characterised the essential oil from Piper auritum, evaluated its cytotoxicity and determined its antileishmanial activity...
  13. ncbi Antiplatelet effects of acidamides isolated from the fruits of Piper longum L
    B S Park
    Institute of Ecological Phytochemistry, Hankyong National University, Ansung City, Kyonggi Do 456 749, Republic of Korea
    Phytomedicine 14:853-5. 2007
    ..of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined...
  14. pmc Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study
    Mohamed Abdalla Estai
    Department of Anatomy, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 66:865-72. 2011
    Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties.
  15. doi In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    J Ethnopharmacol 128:42-8. 2010
    b>Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever.
  16. ncbi Effects of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall on caecal amoebiasis in mice
    Nongyao Sawangjaroen
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand
    J Ethnopharmacol 91:357-60. 2004
    The anti-amoebic effects of crude methanol extracts of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall against Entamoeba histolytica infecting the caecum of mice were studied...
  17. ncbi Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida
    Eun Mi Choi
    Department of Biotechnology and Bioproducts Research Center, Yonsei University, Shinchon Dong 134, Seodaemun gu, Seoul 120 749, South Korea
    J Ethnopharmacol 89:171-5. 2003
    The anti-inflammatory activities of Piper cubeba (fruit), Physalis angulata (flower) and Rosa hybrida (flower) were determined by carrageenan-induced paw edema, arachidonic acid-induced ear edema and formaldehyde-induced arthritis in ..
  18. pmc Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits
    Adel A Amran
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Lipids Health Dis 9:44. 2010
    b>Piper sarmentosum (P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically.
  19. ncbi Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens
    M L A Silva
    Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP 14404 600, Brazil
    Phytother Res 21:420-2. 2007
    The activities of the crude ethanol extract from Piper cubeba seeds, (-)-cubebin and its semi-synthetic derivatives were evaluated against oral pathogens...
  20. doi Benzoic acid derivatives from Piper species and their antiparasitic activity
    Ninoska Flores
    Instituto Universitario de Bio Organica Antonio Gonzalez, Universidad de La Laguna, Avenida Astrofisico Francisco Sanchez 2, La Laguna, 38206 Tenerife, Canary Islands, Spain
    J Nat Prod 71:1538-43. 2008
    b>Piper glabratum and P. acutifolium were analyzed for their content of main secondary constituents, affording nine new benzoic acid derivatives (1, 2, 4, 5, 7, and 10-13), in addition to four known compounds (3, 6, 8, and 9)...
  21. doi Antiparasitic activity of prenylated benzoic acid derivatives from Piper species
    Ninoska Flores
    Instituto Universitario de Bio Organica Antonio Gonzalez, Universidad de La Laguna, Avda Astrofísico, Francisco Sánchez 2, La Laguna, 38206 Tenerife, Canary Islands, Spain
    Phytochemistry 70:621-7. 2009
    Fractionation of dichloromethane extracts from the leaves of Piper heterophyllum and P...
  22. ncbi Metabolism of (-)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species
    Clécio S Ramos
    Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, 748, 05508 900 Sao Paulo, SP, Brazil
    Phytochemistry 69:2157-61. 2008
    The biotransformation of the major Piper solmsianum leaf phenylpropanoids, such as the tetrahydrofuran lignan grandisin and derivatives was investigated in the beetle Naupactus bipes as well as in the caterpillars Heraclides hectorides ..
  23. ncbi Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum
    Roberto C C Martins
    Instituto de Quimica, Universidade de Sao Paulo, C P 26077, 05513 970 Sao Paulo, Brazil
    Phytochemistry 64:667-70. 2003
    ..3,4,5-trimethoxybenzoic acid, isoelemicin and grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and characterized as rel-(7R,8R,7'R,8'R)-3',4'-methylenedioxy-3,4,5,5'-tetramethoxy-7,7'-epoxylignan ..
  24. ncbi Antiproliferative effects of two amides, piperine and piplartine, from Piper species
    Daniel Pereira Bezerra
    Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, P O Box 3157, 60430 270 Fortaleza, Ceara, Brazil
    Z Naturforsch C 60:539-43. 2005
    ..and piperine {1-[5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine}, components obtained from Piper species...
  25. ncbi Hypocrella panamensis sp. nov. (Clavicipitaceae, Hypocreales): a new species infecting scale insects on Piper carrilloanum in Panama
    Mónica S Torres
    Department of Plant Biology and Pathology, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901, USA
    Mycol Res 111:317-23. 2007
    ..In its biological habit Hypocrella panamensis is similar to other species in Hypocrella in that it infects and degrades the scale insect, then grows superficially on nutrients that emerge to the plant surface through the stylet wound...
  26. ncbi Antioxidant activity of piper betel leaf extract and its constituents
    Jitesh S Rathee
    Bio Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    J Agric Food Chem 54:9046-54. 2006
    ..DPPH) assay of the ethanol extracts of three varieties (Bangla, sweet, and Mysore) of Piper betel (pan) revealed the Bangla variety to possess the best antioxidant activity that can be correlated with the ..
  27. ncbi Quantitative determination of anti-fungal and insecticide amides in adult plants, plantlets and callus from Piper tuberculatum by reverse-phase high-performance liquid chromatography
    Hosana M Debonsi Navickiene
    Núcleo de Bioensaio, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Quimica, Universidade Estadual Paulista, CP 355, 14801 970, Araraquara SP, Brazil
    Phytochem Anal 14:281-4. 2003
    ..3) and pellitorine (4) in plants in natura, in plantlets in vitro and ex vitro, and in callus of Piper tuberculatum. Well-resolved peaks were obtained with good detection response and linearity in the range of 15...
  28. ncbi Antifungal activity of Piper guineense of Cameroon
    A Ngono Ngane
    Laboratoire de Biochimie, Faculté des Sciences BP 24157, Douala, Cameroon
    Fitoterapia 74:464-8. 2003
    The antifungal activity of the ethanol extract of the seeds of Piper guineense and some of its fractions obtained by column chromatography was investigated using filamentous fungi and yeasts...
  29. ncbi Toxicity of extracts and isobutyl amides from Piper tuberculatum: potent compounds with potential for the control of the velvetbean caterpillar, Anticarsia gemmatalis
    Hosana M Debonsi Navickiene
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de São Paulo 14040903, Ribeirao Preto SP, Brazil
    Pest Manag Sci 63:399-403. 2007
    ..amides pellitorine (compound 1) and 4,5-dihydropiperlonguminine (compound 2) were extracted from the seeds of Piper tuberculatum Jacq. (Piperaceae) in yields of 6.10 and 4.45% respectively...
  30. ncbi Acaricidal activity and chemical composition of the essential oil from three Piper species
    Alexandre de B F Ferraz
    Programa de Pós Graduação em Genética e Toxicologia, Universidade Luterana do Brasil, Aplicada, Av Farroupilha, 8001 Bairro São José, Canoas, Rio Grande do Sul, Brazil
    Parasitol Res 107:243-8. 2010
    The chemical composition of the essential oil obtained by hydrodistillation of the aerial parts of Piper amalago, Piper mikanianum, and Piper xylosteoides was elucidated by gas chromatography (GC) and GC/mass spectrometry analyses. P...
  31. ncbi Essential oil composition of Piper guineense and its antimicrobial activity. Another chemotype from Nigeria
    O A Oyedeji
    Department of Chemistry, Lagos State University, Lagos State, Nigeria
    Phytother Res 19:362-4. 2005
    The analysis of the essential oil of Piper guineense from Nigeria presents a new chemotype of constituents different from earlier reports with the absence of the usual myristicin...
  32. doi Genetic diversity analysis in Piper species (Piperaceae) using RAPD markers
    Sandeep Sen
    Molecular Biology and Genetic Engineering Research Unit, School of Biosciences, Mar Athanasios College for Advanced Studies, Tiruvalla MACFAST, Kerala, India
    Mol Biotechnol 46:72-9. 2010
    The genetic diversity of eight species of Piper (Piperaceae) viz., P. nigrum, P. longum, P. betle, P. chaba, P. argyrophyllum, P. trichostachyon, P. galeatum, and P...
  33. ncbi Antifungal amides from Piper scutifolium and Piper hoffmanseggianum
    Joaquim V Marques
    Instituto de Quimica, Universidade de Sao Paulo, CP 26077, 05513 970, Sao Paulo, SP, Brazil
    J Nat Prod 70:2036-9. 2007
    Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A ( 1) and scutifoliamide B ( 2), together with the known compounds piperolactam C ( 3), ..
  34. pmc Bioassay-guided isolation of constituents of Piper sarmentosum using a mitochondrial transmembrane potential assay
    Li Pan
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Center for Biostatistics, The Ohio State University, Columbus, Ohio 43210, United States
    J Nat Prod 74:2193-9. 2011
    Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the aerial parts of Piper sarmentosum collected in Vietnam, monitored by a mitochondrial transmembrane potential assay using HT-29 human colon cancer cells...
  35. doi Secondary metabolites isolated from Piper chimonantifolium and their antifungal activity
    Joao Henrique G Lago
    Departamento de Ciências Exatas e da Terra, Universidade Federal de Sao Paulo, 09972 270, Diadema, SP, Brazil
    Nat Prod Res 26:770-3. 2012
    In this study, the CH(2)Cl(2) extract from leaves of Piper chimonantifolium was subjected to several chromatographic separation procedures to afford one chromene (gaudichaudianic acid) as a major compound as well as two flavonoids (..
  36. doi Synthesis of silver nanoparticles using Piper longum leaf extracts and its cytotoxic activity against Hep-2 cell line
    S Justin Packia Jacob
    Department of Biotechnology, St Joseph s College of Engineering, Chennai, Tamil Nadu, India
    Colloids Surf B Biointerfaces 91:212-4. 2012
    ..eco-friendly technique for green synthesis of silver nanoparticles from 1 mM AgNO(3) solution using the extract of Piper longum leaf as reducing as well as capping agent...
  37. doi In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes
    Andrea M Koroishi
    Programa de Pós Graduação em Ciências Farmacêuticas, Brazil
    J Ethnopharmacol 117:270-7. 2008
    The present study was designated to evaluate the in vitro antidermatophyte activity of extracts from leaves of Piper regnellii as well as of the bioactivity-directed isolation of neolignans...
  38. ncbi Leishmanicidal constituents from the leaves of Piper rusbyi
    Ninoska Flores
    Instituto Universitario de Bio Organica Antonio Gonzalez, Universidad de La Laguna, Tenerife, Canary Islands, Spain
    Planta Med 73:206-11. 2007
    The kavapyrone (+)-(7 R,8 S)-epoxy-5,6-didehydrokavain (1) and the chalcone flavokavain B (2) were isolated from Piper rusbyi as the bioactive components by bioassay-guided fractionation, using an in vitro assay against promastigote ..
  39. ncbi Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry
    Leopold Jirovetz
    Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
    J Chromatogr A 976:265-75. 2002
    The investigation of aroma compounds of the essential oils of dried fruits of black pepper (Piper nigrum) and black and white "Ashanti pepper" (Piper guineense) from Cameroon by means of solid-phase microextraction (SPME) was ..
  40. ncbi Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity
    Alicia Hermoso
    Departamento de Parasitologia, Ecologia y Genetica, Facultad de Farmacia, Universidad de La Laguna, Avda Francisco Sánchez s n, La Laguna, 38206 Tenerife, anary Islands, Spain
    Bioorg Med Chem 11:3975-80. 2003
    Two dihydrochalcones (1 and 2) were isolated from Piper elongatum Vahl by activity-guided fractionation against extracellular promastigotes of Leishmania braziliensis in vitro...
  41. doi Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba
    D Jyothi
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Toxicol In Vitro 23:1085-91. 2009
    ..E-piplartine (trans-piplartine), a natural compound isolated from Piper chaba roots is examined against rat histiocytoma (BC-8), mouse embryonal carcinoma (PCC4), mouse macrophages (..
  42. ncbi Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells
    Osamu Ohno
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
    Biosci Biotechnol Biochem 74:1504-6. 2010
    An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells...
  43. ncbi Chemistry and biological activity of essential oils from Piper claussenianum (Piperaceae)
    André M Marques
    Núcleo de Pesquisas de Produtos Naturais NPPN, Centro de Ciencias da Saude, Bloco H, Universidade Federal do Rio de Janeiro UFRJ, CEP 21941 590 Rio de Janeiro, RJ, Brazil
    Nat Prod Commun 5:1837-40. 2010
    Analyses of essential oils obtained from fresh and dried leaves and inflorescences of Piper clausenianum were performed using GC-FID, GC-MS and NMR techniques...
  44. doi Overview for various aspects of the health benefits of Piper longum linn. fruit
    Suresh Kumar
    Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India
    J Acupunct Meridian Stud 4:134-40. 2011
    ..Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine...
  45. ncbi Piper sarmentosum prevents glucocorticoid-induced osteoporotic bone resorption by increasing 11β-hydroxysteroid dehydrogenase type 1 activity
    M R Elvy Suhana
    Department of Anatomy, Universiti Kebangsaan, Malaysia
    Clin Ter 162:313-8. 2011
    ..Therefore, inhibition of this enzyme may reduce bone resorption markers. Piper sarmentosum (Ps) is a potent inhibitor of 11βHSD1 in liver and adipose tissue...
  46. ncbi Comparison of soxhlet, ultrasound-assisted and pressurized liquid extraction of terpenes, fatty acids and Vitamin E from Piper gaudichaudianum Kunth
    Valéria Flores Péres
    Laboratório de Genética Toxicológica, ULBRA, Canoas, RS Brazil Universidad de La Habana, Cuba
    J Chromatogr A 1105:115-8. 2006
    ..of extraction methods of terpenes (terpenic alcohols and phytosterols), fatty acids and Vitamin E from leaves of Piper gaudichaudianum Kunth. The analysis of extracts was done by gas chromatography with mass spectrometric detection...
  47. ncbi Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice
    F Cícero Bezerra Felipe
    Department of Biophysiology, Faculty of Medicine of Juazeiro do Norte, Department of Organic Chemistry of the Federal University of Ceará, Brazil
    Phytomedicine 14:605-12. 2007
    In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod, pentylenetetrazole (PTZ)-induced seizures, ..
  48. doi Antimicrobial activity of flavonoids from Piper lanceaefolium and other Colombian medicinal plants against antibiotic susceptible and resistant strains of Neisseria gonorrhoeae
    Patrick S Ruddock
    Departments of Biology, University of Ottawa, ON, Canada
    Sex Transm Dis 38:82-8. 2011
    ..In the current study, 21 crude methanol extracts, from 19 plants used in Colombian traditional medicine for cutaneous infections, were screened for antimicrobial activity against NG...
  49. ncbi Mosquito larvicidal activity of aqueous extracts of long pepper (Piper retrofractum vahl) from Thailand
    Uruyakorn Chansang
    Division of Medical Entomology, National Institute ofHealth, Department of Medical Sciences, Ministry of Public Health, 88 7 Tiwanon Road, Nonthaburi 11000, Thailand
    J Vector Ecol 30:195-200. 2005
    ..Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae...
  50. ncbi Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase
    Seon A Lee
    College of Pharmacy, Chungbuk National University, Cheongju, 361 763, Korea
    Arch Pharm Res 31:679-83. 2008
    We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities...
  51. ncbi Piper longum inhibits VEGF and proinflammatory cytokines and tumor-induced angiogenesis in C57BL/6 mice
    E S Sunila
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    Int Immunopharmacol 6:733-41. 2006
    The antiangiogenic activity of Piper longum was studied using in vivo as well as in vitro models. In vivo, antiangiogenic activity was studied using B16F-10 melanoma cell-induced capillary formation in C57BL/6 mice...
  52. ncbi 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium
    T Ruegg
    Center for Pharmacognostic Research on Panamanian Flora CIFLORPAN, College of Pharmacy, University of Panama, Apartado 10767, Panama, Panama
    J Ethnopharmacol 103:461-7. 2006
    A new prenylated salicylic acid derivative, 3-farnesyl-2-hydroxy benzoic acid (1), was isolated from the leaves of Piper multiplinervium C. DC. (Piperaceae). It showed anti-Helicobacter pylori activity (MIC 37...
  53. ncbi Anti-inflammatory neolignans from Piper kadsura
    Lie Chwen Lin
    National Research Institute of Chinese Medicine, Taiwan, Republic of China
    J Nat Prod 69:842-4. 2006
    ..known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated...
  54. ncbi Antimycobacterial compounds from Piper sanctum
    Rachel Mata
    Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
    J Nat Prod 67:1961-8. 2004
    Bioassay-guided chromatographic separation of the antimycobacterial extract of the leaves of Piper sanctum afforded 14 new compounds, identified as 2-oxo-12-(3',4'-methylenedioxyphenyl)dodecane (1), 2-oxo-14-(3',4'-methylenedioxyphenyl)..
  55. ncbi Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition
    Seung Woong Lee
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
    Bioorg Med Chem Lett 18:4544-6. 2008
    Eight alkamides 1-8 were isolated by bioassay-guided isolation of EtOH extracts of the fruits of Piper longum and Piper nigum (Piperaceae)...
  56. doi Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil
    Roseli R P de Almeida
    Faculdade de Engenharia Quimica, Universidade Federal do Para, Campus Universitario do Guama, 66075 900 Belém, PA, Brazil
    Chem Biodivers 6:1427-34. 2009
    The essential oils of the specimens of Piper aduncum that occur in deforested areas of Brazilian Amazon, North Brazil, are rich in dillapiole (35-90%), a derivative of phenylpropene, to which are attributed biological properties...
  57. ncbi Induction of epidermal proliferation and expressions of PKC and NF-kappaB by betel quid extracts in mouse: the role of lime-piper additives in betel quid
    Miao Jane Lee
    Institute of Biochemistry, Chung Shan Medical University, No 110, Section 1, Chien Kuao N Road, Taichung 402, Taiwan
    Chem Biol Interact 140:35-48. 2002
    ..In this study, the promoting effects of BQ and lime-piper additives (LPA) in BQ on epidermal hyperplasia in CD-1 mouse skin are investigated...
  58. ncbi Preliminary pharmacological studies on Piper chaba stem bark
    Md Taufiq-Ur-Rahman
    School of Biological Sciences, University of Manchester, Oxford Road, M13 9PL Manchester, UK
    J Ethnopharmacol 99:203-9. 2005
    b>Piper chaba Hunter (Piperaceae) is a common pepper in the southern part of Bangladesh. Various parts of this plant have been extensively used in different traditional formulations including ayurveda...
  59. ncbi Phytochemical studies on the seed extract of Piper nigrum Linn
    Munawwer Rasheed
    H E J Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:703-12. 2005
    The petroleum ether extract of dried ground seeds of Piper nigrum Linn...
  60. doi Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav
    A Quilez
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Calle Prof García González, 2, 41012 Seville, Spain
    J Ethnopharmacol 128:583-9. 2010
    The leaves of Piper carpunya Ruiz & Pav. (syn Piper lenticellosum C.D.C...
  61. pmc Piper sarmentosum inhibits ICAM-1 and Nox4 gene expression in oxidative stress-induced human umbilical vein endothelial cells
    Azizah Ugusman
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    BMC Complement Altern Med 11:31. 2011
    Aqueous extract of Piper sarmentosum (AEPS) is known to possess antioxidant and anti-atherosclerotic activities but the mechanism responsible for it remains unclear...
  62. doi Piper umbellatum L.: a comparative cross-cultural analysis of its medicinal uses and an ethnopharmacological evaluation
    Carles M F B Roersch
    Instituto de Medicina Dominicana, PO Box 160, Santo Domingo, Dominican Republic
    J Ethnopharmacol 131:522-37. 2010
    ..This review assesses the botany, traditional medicinal uses, phytochemistry, pharmacology and toxicology of P. umbellatum...
  63. doi Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae)
    D Rodrigues Silva
    Department of Pharmacy and Pharmacology, State University of Maringa, 87020900 Maringa, Brazil
    J Ethnopharmacol 116:569-73. 2008
    Leaves of Piper ovatum are known in folk medicine as "joão burandi" or "anestésica" and in traditional Brazilian medicine are used to treat inflammatory disease...
  64. ncbi Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum
    Joao Henrique G Lago
    Instituto de Quimica, Universidade de Sao Paulo, C P 26077 05599 970, Sao Paulo, SP, Brazil
    J Nat Prod 67:1783-8. 2004
    b>Piper crassinervium, P. aduncum, P. hostmannianum, and P...
  65. pmc Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet
    Adel A Amran
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Lipids Health Dis 10:2. 2011
    ..The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P...
  66. pmc Piper sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cells
    Azizah Ugusman
    Department of Physiology, Universiti Kebangsaan, Malaysia Medical Center, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 65:709-14. 2010
    ..b>Piper sarmentosum is a tropical plant with antioxidant and anti-inflammatory activities...
  67. doi Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl
    Daniel Rodrigues Silva
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Molecules 14:1171-82. 2009
    ..Hydroalcoholic extracts of different parts of Piper ovatum Vahl, essential oil andamides isolated from leaves were tested against Gram-positive and Gram-negative ..
  68. ncbi Antioxidant activity of prenylated hydroquinone and benzoic acid derivatives from Piper crassinervium Kunth
    Lydia F Yamaguchi
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Cx Postal 26077, CEP 05599 970, Brazil
    Phytochemistry 67:1838-43. 2006
    ..The prenylated hydroquinones had higher antioxidant activity than the benzoic acids and, among the hydroquinones, the E isomer was more efficient than the Z isomer...
  69. ncbi HPLC assisted chemobiological standardization of alpha-glucosidase-I enzyme inhibitory constituents from Piper longum Linn-An Indian medicinal plant
    Srinivas V Pullela
    Natural Products Laboratory, Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    J Ethnopharmacol 108:445-9. 2006
    ..However, effective quality control methods in order to select right quality materials are lacking. Though Piper longum is a widely used herb in several Ayurvedic formulations prescribed for various diseases, there is no ..
  70. ncbi Enzymatic and non-enzymatic antioxidants in selected Piper species
    J Karthikeyan
    Department of Biochemistry, PSG College of Arts and Science, Coimbatore 641 004, India
    Indian J Exp Biol 41:135-40. 2003
    b>Piper species, commonly used in diet and traditional medicine were assessed for their antioxidant potential...
  71. ncbi Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor
    Masaya Iwashita
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan
    Biol Pharm Bull 30:1221-5. 2007
    b>Piper longum L. has been used as a crude drug for the treatment of disorders of poor peripheral blood circulation in Asia. However, the detailed mechanism of its action has not been clarified as yet...
  72. ncbi Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats
    Alok S Wakade
    Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology Nathalal Parikh Marg, Matunga, Mumbai 400 019, India
    Indian J Exp Biol 46:528-33. 2008
    ..The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity...
  73. doi Bioactive aristolactams from Piper umbellatum
    Turibio Kuiate Tabopda
    Laboratoire de Chimie Organique des Substances Naturelles, LC3 UMR 7177 CNRS, Universite Louis Pasteur, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg, France
    Phytochemistry 69:1726-31. 2008
    Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-..
  74. ncbi Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?
    A J M Christina
    Department of Pharmacology, KM College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India
    Phytomedicine 13:196-8. 2006
    This study was carried out to evaluate the antifibrotic effect of ethanol extract of the fruits of Indian herb Piper longum Linn. Liver fibrosis was induced in rats by CCl(4) administration...
  75. ncbi Synergistic effects of three Piper amides on generalist and specialist herbivores
    L A Dyer
    Department of Ecology and Evolutionary Biology, 310 Dinwiddie Hall, Tulane University, New Orleans, Louisiana 70118, USA
    J Chem Ecol 29:2499-514. 2003
    The tropical rainforest shrub Piper cenocladum, which is normally defended against herbivores by a mutualistic ant, contains three amides that have various defensive functions...
  76. ncbi Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense
    Bénédicte Portet
    UMR 152, IRD Université Paul Sabatier Toulouse 3, Faculte des sciences pharmaceutiques, 31062 Toulouse Cedex 09, France
    Phytochemistry 68:1312-20. 2007
    The bioassay-guided purification of an n-hexane extract from the leaves of Piper hostmannianum var...
  77. ncbi Chemical constituents of the roots of Piper sarmentosum
    Pittaya Tuntiwachwuttikul
    Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand
    Chem Pharm Bull (Tokyo) 54:149-51. 2006
    Sixteen compounds were isolated from the fresh roots of Piper sarmentosum...
  78. pmc Complete plastid genome sequences of Drimys, Liriodendron, and Piper: implications for the phylogenetic relationships of magnoliids
    Zhengqiu Cai
    Section of Integrative Biology and Institute of Cellular and Molecular Biology, Patterson Laboratories 141, University of Texas, Austin, TX 78712, USA
    BMC Evol Biol 6:77. 2006
    ..We sequenced the plastid genomes of three magnoliids, Drimys (Canellales), Liriodendron (Magnoliales), and Piper (Piperales), and used these data in combination with 32 other angiosperm plastid genomes to assess phylogenetic ..
  79. pmc Geographic variation in host-specificity and parasitoid pressure of an herbivore (geometridae) associated with the tropical genus piper (piperaceae)
    Heidi Connahs
    Tulane University, New Orleans, LA 70118, USA
    J Insect Sci 9:28. 2009
    ..The goals of this research were to examine: 1) whether Eois are specialized on the genus Piper (Piperaceae) and if hostplant specialization varies geographically; 2) whether Eois are equally vulnerable to ..
  80. ncbi In vitro antioxidant activity of three Piper species
    Gabriel A Agbor
    Department of Chemistry, University of Scranton, Scranton, PA, 18510, USA
    J Herb Pharmacother 7:49-64. 2007
    ..This study assesses the methanolic extracts of the leaves of three Piper species (Piper guineense Schum and Thonn., Piper nigrum L. and Piper umbellatum L...
  81. ncbi In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi
    Adriana Aparecida Lopes
    Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil
    Nat Prod Res 22:1040-6. 2008
    This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated...
  82. ncbi [Antidepressant amides from Piper laetispicum C. DC]
    Sheng li Pan
    School of Pharmacy, Fudan University, Shanghai 200032, China
    Yao Xue Xue Bao 40:355-7. 2005
    To investigate the antidepressant constituents of Piper laetispicum C. DC.
  83. ncbi Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells
    Kyung Rak Min
    College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Chenogju, Korea
    Planta Med 70:1115-8. 2004
    ..In our ongoing study to find melanogenesis inhibitors from natural sources, Piper longum L (fruits, Piperaceae) was discovered to have an inhibitory effect on alpha-melanocyte-stimulating hormone (..
  84. ncbi New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens
    Ian Lih Tsai
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Planta Med 71:535-42. 2005
    ..E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses...
  85. ncbi Attraction of the fruit-eating bat Carollia perspicillata to Piper gaudichaudianum essential oil
    Sandra Bos Mikich
    Laboratorio de Ecologia, Embrapa Florestas Caixa Postal 319 83411 000 Colombo, PR, Brazil
    J Chem Ecol 29:2379-83. 2003
    We performed field tests using mimetic Piper fruits with and without essential oil extracted through hydrodistillation from Piper gaudichaudianum ripe fruits in order to evaluate the role of odor in Carollia perspicillata attraction and ..
  86. doi Inter- and intraspecific comparisons of antiherbivore defenses in three species of rainforest understory shrubs
    R M Fincher
    Department of Ecology and Evolutionary Biology, Tulane University, 400 Boggs, New Orleans, LA 70118, USA
    J Chem Ecol 34:558-74. 2008
    ..We examined trade-offs among defenses in closely related tropical rain forest shrubs (Piper cenocladum, P. imperiale, and P...
  87. ncbi Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens
    M Singh
    Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Himachal Pradesh, India
    J Vet Sci 6:197-200. 2005
    ..profile of orally administered oxytetracycline (10 mg/kg body weight) was studied 7 days post oral treatment of Piper longum (15 mg equivalent/kg) in White Leghorn hens (2-2.8 kg)...
  88. ncbi Chemical constituents and bioactivity of Piper sarmentosum
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Ethnopharmacol 93:173-6. 2004
    ..methyl piperate (12) and a mixture of beta-sitosterol (13) and stigmasterol (14), were isolated from the fruits of Piper sarmentosum (Piperaceae)...
  89. ncbi Piper longum Linn. Extract inhibits TNF-alpha-induced expression of cell adhesion molecules by inhibiting NF-kappaB activation and microsomal lipid peroxidation
    Naresh Singh
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, University of Delhi Campus North, Mall Road, Delhi 110 007, India
    Phytomedicine 15:284-91. 2008
    ..Here, we have evaluated the effect of Piper longum chloroform extract (PlCE) on TNF-alpha-induced expression of ICAM-1 on endothelial cells and on NADPH-..
  90. ncbi Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
    Vitelbina Núñez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Phytochemistry 66:1017-25. 2005
    ..b>Piper umbellatum and Piper peltatum extracts tested positive, and their fractionation resulted in the isolation of 4-..
  91. ncbi Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium
    L G Lala
    Department of Pharmacognosy and Phytochemistry, Prin K M Kundnani College of Pharmacy, Dr R G Thadani Marg, Worli, Mumbai 400 018, India
    J Ethnopharmacol 91:277-80. 2004
    Trikatu"-an Ayurvedic formulation comprising of a 1:1:1 ratio of dried fruits of Piper nigrum, Piper longum and dried rhizomes of Zingiber officinale is widely used to enhance the bioavailability of drugs, like vasicine, indomethacin, ..
  92. ncbi Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats
    Ramasamy Subramanian Vijayakumar
    Department ofBiochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
    J Basic Clin Physiol Pharmacol 17:71-86. 2006
    ..To study the effect of piperine, an alkaloid, on thyroid hormones and apolipoproteins in high-fat-diet (HFD) and antithyroid drug-induced hyperlipidemic rats...
  93. ncbi Analysis of minor flavonoids in Piper hostmannianum var. berbicense using liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry
    Bénédicte Portet
    Universite de Toulouse, UMR 152 IRD UPS Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, Faculte des sciences pharmaceutiques, Universite Paul Sabatier, F 31062 Toulouse Cedex 09, France
    J Chromatogr A 1210:45-54. 2008
    ..Some of them have been isolated from the leaves of Piper hostmannianum var. berbicense and standards were used to confirm their fragmentation behaviour...
  94. ncbi A new aristolactam alkaloid and anti-platelet aggregation constituents from Piper taiwanense
    Yu Chang Chen
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Planta Med 70:174-7. 2004
    A new alkaloid, piperolactam E, and fourteen known compounds have been isolated from the stem of Piper taiwanense...
  95. ncbi Repellency of essential oil of Piper aduncum against Aedes albopictus in the laboratory
    Norashiqin Misni
    Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur, Malaysia
    J Am Mosq Control Assoc 25:442-7. 2009
    The repellent activity of Piper aduncum essential oil against Aedes albopictus was investigated under laboratory conditions with human volunteers. The lowest median effective dose (ED50) value was 1...
  96. ncbi Protective effect of Piper longum fruit ethanolic extract on radiation induced damages in mice: a preliminary study
    E S Sunila
    Amala Cancer Research Centre, Trissur, India
    Fitoterapia 76:649-55. 2005
    The radioprotective property of an ethanolic extract of Piper longum fruits (EEPLF) was investigated in Swiss mice...
  97. ncbi Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics
    A Khajuria
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Phytomedicine 9:224-31. 2002
    Piperine (1-Piperoyl piperidine) is a major alkaloid of Piper nigrum Linn. and Piper longum Linn. It is shown to possess bioavailability-enhancing activity with various structurally and therapeutically diverse drugs...
  98. ncbi Optimization of pressurized liquid extraction of Piper gaudichaudianum Kunth leaves
    Valéria Flores Péres
    Laboratório de Genética Toxicológica, ULBRA, Canoas, RS, Brazil Universidad de La Habana, Cuba
    J Chromatogr A 1105:148-53. 2006
    Piperaceae family is original from tropical regions and it shows more than 700 species around the world. Piper gaudichaudianum Kunth is the specie more abundant in Brazil, occurring from Northeast to South Brazil...
  99. ncbi Evaluation of antifungal activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)
    Marina Pereira De Campos
    Programa de Mestrado em Ciências Farmacêuticas CCS and Núcleo de Investigações Químico Farmacêuticas NIQFAR, Universidade do Vale do Itajai UNIVALI, 88302 202, Itajaí SC, Brazil
    Biol Pharm Bull 28:1527-30. 2005
    ..acetate) and four pure compounds: eupomatenoid-3 (1), eupomatenoid-5 (2), conocarpan (3) and orientin (4), from Piper solmsianum, for possible antifungal activity against 12 pathogenic fungi...
  100. ncbi Potential antiamoebic property of the roots of Piper longum Linn
    Sheela Ghoshal
    Division of Microbiology, Central Drug Research Institute, Lucknow 226 001, India
    Phytother Res 16:689-91. 2002
    In an earlier study we reported the effect of ethanol extracts of Piper longum fruit against caecal amoebiasis in rats. A follow-up study to determine whether the roots possess similar antiamoebic activity was carried out...
  101. ncbi A new method of synthesis and antibacterial activity evaluation of piper amides
    P V Srinivas
    Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Nat Prod Res 18:95-8. 2004
    Several natural piper amides and their mimics were synthesized by developing a new strategy of amide formation...

Research Grants89

  1. POST-CORONARY ADAPTATION IN WOMEN--NURSING INTERVENTION
    FILOMENA VARVARO; Fiscal Year: 1992
    ..Impact Scale, Psychological General Well-Being Index, and Perceived Health Assessment and Risk Protection Survey; Piper Fatigue Scale, Multidimensional Pain Inventory, Self Care and Leisure Time Activity Scale; 3) physiological ..
  2. FOLYLPOLYGLUTAMATE SYNTHETASE IN CANCER CHEMOTHERAPY
    John McGuire; Fiscal Year: 1992
    ..Syntheses are performed by recognized experts in antifol chemistry, principally Drs. M.G. Nair and J.R. Piper. All antifols will be fully characterized in this lab...
  3. Enhancing Bioavailability of Resveratrol
    Howard H Bailey; Fiscal Year: 2010
    ..Studies have also shown that piperine, an alkaloid derived from black pepper (Piper spp.), inhibits glucuronidation in vivo...
  4. VIRTUAL REALITY INTERVENTION FOR OLDER WOMEN W/ BREAST CANCER
    Susan Schneider; Fiscal Year: 2002
    ..Specific measures of symptom distress will include the Revised Piper Fatigue Scale, and the State Anxiety...
  5. VIRTUAL REALITY INTERVENTION FOR OLDER WOMEN W/ BREAST CANCER
    Susan Schneider; Fiscal Year: 2001
    ..Specific measures of symptom distress will include the Revised Piper Fatigue Scale, and the State Anxiety...
  6. GPU Accelerated Protein Docking Software with Flexible Refinement
    MARTIN C HERBORDT; Fiscal Year: 2012
    ..on the results of CAPRI (Critical Assessment of Predicted Interactions), a worldwide protein docking competition, PIPER, developed at Boston University and licensed to Acpharis, is the best protein-protein docking program currently ..
  7. Exercise: Intervention for fatigue in cancer patients
    Marilyn Dodd; Fiscal Year: 2000
    ..The primary outcome measure is fatigue, as measured by self-report (Piper Fatigue Scale (PFSF) and a one-item Fatigue Intensity Scale (FIS)...
  8. ERP/MRP INDICES OF EARLY DEVELOPMENT IN INFANTS W/DS
    JENNIFER HILL KARRER; Fiscal Year: 2001
    ..1993; Gibson and Harris, 1988; Piper et al., 1986)...
  9. ERP/MRP INDICES OF EARLY DEVELOPMENT IN INFANTS W/DS
    JENNIFER HILL KARRER; Fiscal Year: 2003
    ..1993; Gibson and Harris, 1988; Piper et al., 1986)...
  10. PIPER: PROSTATE IMPLANT PLANNING ENGINE FOR RADIOTHERAPY
    Yan Yu; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATION PIPER will be marketed as a standalone computer treatment planning system for intraoperative dose optimization and ..
  11. ERP/MRP INDICES OF EARLY DEVELOPMENT IN INFANTS W/DS
    JENNIFER HILL KARRER; Fiscal Year: 2002
    ..1993; Gibson and Harris, 1988; Piper et al., 1986)...
  12. ERP/MRP INDICES OF EARLY DEVELOPMENT IN INFANTS W/DS
    JENNIFER HILL KARRER; Fiscal Year: 2005
    ..1993; Gibson and Harris, 1988; Piper et al., 1986)...
  13. ERP/MRP INDICES OF EARLY DEVELOPMENT IN INFANTS W/DS
    JENNIFER HILL KARRER; Fiscal Year: 2000
    ..1993; Gibson and Harris, 1988; Piper et al., 1986)...
  14. PIPER: PROSTATE IMPLANT PLANNING ENGINE FOR RADIOTHERAPY
    Yan Yu; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATION PIPER will be marketed as a standalone computer treatment planning system for intraoperative dose optimization and ..
  15. FOLYLPOLYGLUTAMATE SYNTHETASE IN CANCER CHEMOTHERAPY
    John McGuire; Fiscal Year: 1990
    ..b>Piper) and (b) the gamma-tetrazole folate analogs (Dr...
  16. Cognitive-Behavioral Therapy for Chronic Insomnia after Breast Cancer Treatment
    Ellyn Matthews; Fiscal Year: 2007
    ..Beliefs and Attitudes about Sleep-16, EORTC Quality of Life Questionnaire C30, Attentional Function Index, Revised Piper Fatigue Scale, and Hospital Anxiety and Depression Scale. Subjective data will be corroborated with actigraphy...
  17. Cognitive-Behavioral Therapy for Chronic Insomnia after Breast Cancer Treatment
    Ellyn Matthews; Fiscal Year: 2009
    ..Beliefs and Attitudes about Sleep-16, EORTC Quality of Life Questionnaire C30, Attentional Function Index, Revised Piper Fatigue Scale, and Hospital Anxiety and Depression Scale. Subjective data will be corroborated with actigraphy...
  18. Depression and Smoking: The Role of Gender and Cognitive Control.
    Lisa Fucito; Fiscal Year: 2007
    ..g., Baker, Piper, McCarthy, Majeskie, & Fiore, 2004); however, to date the research on these factors has been scarce...
  19. TRAFECTORY OF FATIGUE IN BREAST & OVARIAN CANCER PATIENTS ON CHEMOTHERAPY
    Judith Payne; Fiscal Year: 1999
    ..factors, determine the extent select physiological variables contribute to the fatigue experience as measured by Piper's Fatigue Scale and determine if there is a relationship between the trajectory of fatigue and the presence of ..
  20. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2004
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  21. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  22. Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma
    Stuart Shalat; Fiscal Year: 2007
    ..The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing...
  23. Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma
    Stuart Shalat; Fiscal Year: 2009
    ..The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing...
  24. Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma
    Stuart Shalat; Fiscal Year: 2009
    ..The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing...
  25. Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma
    Stuart Shalat; Fiscal Year: 2008
    ..The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing...
  26. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2004
    ..Using selected factors from Piper's Integrated Fatigue Model (IFM), a randomized, controlled clinical trial will compare women with breast cancer ..
  27. Modeling of Protein Interactions 2007
    Sandor Vajda; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. FAMILY FUNCTION, STROKE RECOVRY, AND CAREGIVER OUTCOMES
    Patricia Clark; Fiscal Year: 2001
    ....
  29. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2003
    ..Using selected factors from Piper's Integrated Fatigue Model (IFM), a randomized, controlled clinical trial will compare women with breast cancer ..
  30. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2009
    ....
  31. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2005
    ..Preliminary results show that these strategies will substantially improve docking results for relatively weak complexes that frequently play important roles in immune recognition, signal transduction, and cell cycle control. ..
  32. Improved Protein Mapping for Fragment-Based Drug Design
    Sandor Vajda; Fiscal Year: 2005
    ..Preliminary results suggest that mapping with fragments from well designed libraries will provide very useful information for drug design. ..
  33. FAMILY FUNCTION, STROKE RECOVRY, AND CAREGIVER OUTCOMES
    Patricia Clark; Fiscal Year: 2000
    ....
  34. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2006
    ..Preliminary results show that these strategies will substantially improve docking results for relatively weak complexes that frequently play important roles in immune recognition, signal transduction, and cell cycle control. ..
  35. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2008
    ..Results will help to understand both the principles that govern the weakly specific binding of small molecules in functional sites of proteins and the potential limitations of the mapping method. ..
  36. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2000
    ..An automatic procedure combining Fourier docking programs with the post- and pre-processing steps will provide a powerful research tool in applications that currently cannot be addressed by computational methods. ..
  37. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2000
    ..abstract_text> ..
  38. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2001
    ..Finally, we will measure how the muscles are actually used in vivo, to better understand the molecular desig for different motor functions. ..
  39. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2006
    ..Using selected factors from Piper's Integrated Fatigue Model (IFM), a randomized, controlled clinical trial will compare women with breast ..
  40. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2006
    ..abstract_text> ..
  41. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2002
    ..abstract_text> ..
  42. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2005
    ..Using selected factors from Piper's Integrated Fatigue Model (IFM), a randomized, controlled clinical trial will compare women with breast cancer ..
  43. Sleep Disturbances in People with Cancer and Caregivers
    Ann Berger; Fiscal Year: 2004
    ..abstract_text> ..
  44. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 1992
    ..These approaches will give us new insights into how muscle is designed and the functional importance of the observed variation seen in different fiber types...
  45. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2003
    ..abstract_text> ..
  46. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2003
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  47. Fatigue & Breast Cancer-A Behavioral Sleep Intervention
    Ann Berger; Fiscal Year: 2002
    ..Using selected factors from Piper's Integrated Fatigue Model (IFM), a randomized, controlled clinical trial will compare women with breast cancer ..
  48. PPAR-y agonists, RA and cardiovascular disease
    Mariana J Kaplan; Fiscal Year: 2010
    ..This study will also shed further light on the biology of endothelial cell injury in RA. ..
  49. Novel Approaches to Blood Brain Barrier Function
    Alex Avdeef; Fiscal Year: 2008
    ....
  50. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2010
    ..Results will help to understand both the principles that govern the weakly specific binding of small molecules in functional sites of proteins and the potential limitations of the mapping method. ..
  51. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 1999
    ..Finally, we will measure how the muscles are actually used in vivo, to better understand the molecular desig for different motor functions. ..
  52. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2000
    ..Finally, we will measure how the muscles are actually used in vivo, to better understand the molecular desig for different motor functions. ..
  53. Meaning-Centered Group Psychotherapy in Advanced Cancer
    William Breitbart; Fiscal Year: 2009
    ..novel and innovative psychotherapy intervention for patients with advanced cancer, incorporating spiritual (meaning-centered) elements, which holds great promise in the treatment of spiritual suffering at the end-of-life ..
  54. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2009
    ..Results will help to understand both the principles that govern the weakly specific binding of small molecules in functional sites of proteins and the potential limitations of the mapping method. ..
  55. DESIRE FOR DEATH AMONG TERMINALLY ILL PATIENTS WITH AIDS
    William Breitbart; Fiscal Year: 1999
    ....
  56. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 1999
    ..abstract_text> ..
  57. Meaning-Centered Group Psychotherapy in Advanced Cancer
    William Breitbart; Fiscal Year: 2010
    ..novel and innovative psychotherapy intervention for patients with advanced cancer, incorporating spiritual (meaning-centered) elements, which holds great promise in the treatment of spiritual suffering at the end-of-life ..
  58. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2010
    ....
  59. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2009
    ..We focus on the identification and characterization of druggable sites capable of binding small molecular inhibitors of protein-protein interactions, an important emerging problem in pharmaceutical research. ..
  60. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2008
    ..Preliminary results show that these strategies will substantially improve docking results for relatively weak complexes that frequently play important roles in immune recognition, signal transduction, and cell cycle control. ..
  61. DESIRE FOR DEATH AMONG TERMINALLY ILL PATIENTS WITH AIDS
    William Breitbart; Fiscal Year: 2000
    ....
  62. Computational Mapping of Proteins for Binding of Ligands
    Sandor Vajda; Fiscal Year: 2007
    ..Results will help to understand both the principles that govern the weakly specific binding of small molecules in functional sites of proteins and the potential limitations of the mapping method. ..
  63. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2004
    ..Preliminary results show that these strategies will substantially improve docking results for relatively weak complexes that frequently play important roles in immune recognition, signal transduction, and cell cycle control. ..
  64. Ecology Momentary Assessment of College Smoking
    THOMAS PIASECKI; Fiscal Year: 2003
    ..This project has the potential to address key questions about the early smoking career in a population at risk for the development of chronic tobacco dependence. ..
  65. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2001
    ..An automatic procedure combining Fourier docking programs with the post- and pre-processing steps will provide a powerful research tool in applications that currently cannot be addressed by computational methods. ..
  66. Meaning-Centered Psychotherapy in Advanced Cancer
    William Breitbart; Fiscal Year: 2002
    ..Larger, randomized controlled trials of Meaning-Centered Group Psychotherapy will be conducted in the future utilizing the insights learned from this pilot intervention study. ..
  67. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2003
    ..abstract_text> ..
  68. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2004
    ..abstract_text> ..
  69. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2001
    ..An automatic procedure combining Fourier docking programs with the post- and pre-processing steps will provide a powerful research tool in applications that currently cannot be addressed by computational methods. ..
  70. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2006
    ..abstract_text> ..
  71. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2007
    ..abstract_text> ..
  72. DEPRESSION/DESIRE FOR DEATH IN TERMINAL CANCER PATIENTS
    William Breitbart; Fiscal Year: 2003
    ..This study is expected to provide a direct evaluation of desire for death in terminally ill cancer patients, and to ascertain whether a pharmacological treatment for depression influences desire for death. ..
  73. Individual Meaning-Centered Psychotherapy in Advanced Cancer Patients
    William Breitbart; Fiscal Year: 2010
    ....
  74. FAMILY FUNCTION, STROKE RECOVRY, AND CAREGIVER OUTCOMES
    Patricia Clark; Fiscal Year: 2002
    ....
  75. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2002
    ..An automatic procedure combining Fourier docking programs with the post- and pre-processing steps will provide a powerful research tool in applications that currently cannot be addressed by computational methods. ..
  76. PPAR-y agonists, RA and cardiovascular disease
    Mariana Kaplan; Fiscal Year: 2009
    ..This study will also shed further light on the biology of endothelial cell injury in RA. ..
  77. DEPRESSION/DESIRE FOR DEATH IN TERMINAL CANCER PATIENTS
    William Breitbart; Fiscal Year: 2001
    ..This study is expected to provide a direct evaluation of desire for death in terminally ill cancer patients, and to ascertain whether a pharmacological treatment for depression influences desire for death. ..
  78. Conference Modeling of Protein Interactions in Genomes
    Sandor Vajda; Fiscal Year: 2005
    ..This will primarily achieved by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions. ..
  79. A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKING
    Sandor Vajda; Fiscal Year: 2007
    ..Preliminary results show that these strategies will substantially improve docking results for relatively weak complexes that frequently play important roles in immune recognition, signal transduction, and cell cycle control. ..
  80. Novel Approaches to Blood Brain Barrier Function
    Alex Avdeef; Fiscal Year: 2007
    ....