sanguinaria

Summary

Summary: A plant genus of the family PAPAVERACEAE. S. canadensis is the source of sanguinarine extract used in MOUTHWASHES.

Top Publications

  1. ncbi A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet
    A G Affleck
    Br J Dermatol 157:1078-9. 2007
  2. ncbi In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis
    Gail B Mahady
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Phytother Res 17:217-21. 2003
  3. ncbi Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.)
    Tyler N Graf
    Natural Products Laboratory, Trace Inorganics Department, and Social and Statistical Sciences, Research Triangle Institute, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    J Agric Food Chem 55:1205-11. 2007
  4. pmc Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial
    Jean Claude Colau
    Department of Gynaecology, Hospital Foch, Suresnes, France
    Drugs R D 12:107-19. 2012
  5. doi BOA detoxification of four summer weeds during germination and seedling growth
    Margot Schulz
    IMBIO Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Bonn, Germany
    J Chem Ecol 38:933-46. 2012
  6. doi Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway
    Jun Sik Lee
    Heart Research Center of Chonnam National University Hospital, Cardiovascular Research Institute of Chonnam National University, Gwangju 501 757, Korea
    Int J Toxicol 31:70-7. 2012
  7. ncbi Amplified fragment length polymorphism-based genetic relationships among weedy Amaranthus species
    J J Wassom
    Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA
    J Hered 96:410-6. 2005
  8. ncbi The antimicrobial screening of a Barbadian medicinal plant with indications for use in the treatment of diabetic wound infections
    S Carrington
    Faculty of Medical Sciences, The University of the West Indies, Cave Hill, Barbados
    West Indian Med J 61:861-4. 2012
  9. ncbi Water stress and nitrogen limitation effects on corn (Zea mays L.) competition with a C3 and a C4 weed
    E Zand
    Department of Weed Research, Plant Pest and Disease Research Institute, P O Box 19395 1454, Tehran, Iran
    Commun Agric Appl Biol Sci 71:753-60. 2006
  10. ncbi Interference of redroot pigweed (Amaranthus retroflexus L.) in green bean (Phaseolus vulgaris L.)
    B Mirshekari
    Islamic Azad University of Tabriz, Faculty of Agriculture, Department of Agronomy and Plant Breeding, Iran
    Commun Agric Appl Biol Sci 71:775-80. 2006

Research Grants

Scientific Experts

  • G Basini
  • Mark Fuhrmann
  • Kyle M Turner
  • María C Carrasquilla
  • J H Ness
  • Michael O Childress
  • John J Cienki
  • David S Senchina
  • Chuihua Kong
  • R Jaggi
  • G Scheiner-Bobis
  • G B Mahady
  • Pavel Kosina
  • M Gonzalez Begne
  • Nathaniel Jellinek
  • L Suntornsuk
  • Nihal Ahmad
  • Min Ho Han
  • Yung Hyun Choi
  • Vaqar Mustafa Adhami
  • Jana Suchomelová
  • Jiiang Huei Jeng
  • Mei Chi Chang
  • Ana Burgeiro
  • Jun Sik Lee
  • Michael Z Wang
  • S Carrington
  • Christian Vlachojannis
  • Margot Schulz
  • Jean Claude Colau
  • Brice W Obiang-Obounou
  • Marika Janovska
  • Eduar Elías Bejarano
  • Elizabeth A Mazzio
  • Woo Young Choi
  • Won Ho Lee
  • Anna M Moran
  • Donald R Laub
  • Brigida D'Abrosca
  • Sereen M B Bataineh
  • Shin Kim
  • M F Bordet
  • Gi Young Kim
  • Taeg Kyu Kwon
  • Azhar R Hussain
  • Eva Taborska
  • A G Affleck
  • Daniel Jancula
  • Ying Jan Wang
  • Bor Ru Lin
  • Tyler N Graf
  • Po Hsuen Lee
  • Ron Baughman
  • B Mirshekari
  • E Zand
  • Suk Jin Hong
  • J J Wassom
  • J Earl Creech
  • Jong Pil Eun
  • Moammir Hasan Aziz
  • Hasan Mukhtar
  • Sandra M Newton
  • Richard W Weber
  • Shana McDaniel
  • Sultan H Begna
  • Paulo J Oliveira
  • Consuelo Gajate
  • Faustino Mollinedo
  • Ana C Bento
  • Florella Magora
  • Won Kyo Jung
  • Vincenzo Tabaglio
  • Sigrun Chrubasik
  • D H Cohall
  • Philippe Marijnen
  • J F Lindo
  • Taek Rim Yoon
  • Erin M Warshaw
  • Stephane Vincent
  • Francois Andre Allaert
  • Adriano Marocco
  • Hyung Keun Kim
  • M Gossell-Williams
  • Myung Ho Jeong
  • Ok Hwa Kang
  • Young Guk Kim
  • Dong Yeul Kwon
  • Joon Ho Keum
  • Sung Bae Kim
  • Jang Gi Choi

Detail Information

Publications59

  1. ncbi A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet
    A G Affleck
    Br J Dermatol 157:1078-9. 2007
  2. ncbi In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis
    Gail B Mahady
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Phytother Res 17:217-21. 2003
    Methanol extracts of the rhizomes of Sanguinaria canadensis, and the roots and rhizomes of Hydrastis canadensis, two plants used traditionally for the treatment of gastrointestinal ailments, were screened for in vitro antibacterial ..
  3. ncbi Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.)
    Tyler N Graf
    Natural Products Laboratory, Trace Inorganics Department, and Social and Statistical Sciences, Research Triangle Institute, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    J Agric Food Chem 55:1205-11. 2007
    Populations of bloodroot [Sanguinaria canadensis L. (Papaveraceae)] are found throughout the eastern forests of North America, with particular abundance in the southern Appalachian Mountains...
  4. pmc Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial
    Jean Claude Colau
    Department of Gynaecology, Hospital Foch, Suresnes, France
    Drugs R D 12:107-19. 2012
    ..Homeopathic medicines have a place among the non-hormonal therapies for the treatment of hot flashes during the menopause...
  5. doi BOA detoxification of four summer weeds during germination and seedling growth
    Margot Schulz
    IMBIO Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Bonn, Germany
    J Chem Ecol 38:933-46. 2012
    ..Therefore, detoxification processes affect the potential for weed suppression by soil allelochemicals in sustainable weed management...
  6. doi Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway
    Jun Sik Lee
    Heart Research Center of Chonnam National University Hospital, Cardiovascular Research Institute of Chonnam National University, Gwangju 501 757, Korea
    Int J Toxicol 31:70-7. 2012
    Sanguinarine is an alkaloid obtained from the bloodroot plant Sanguinaria canadensis and has beneficial effects on oxidative stress and inflammatory disorders...
  7. ncbi Amplified fragment length polymorphism-based genetic relationships among weedy Amaranthus species
    J J Wassom
    Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA
    J Hered 96:410-6. 2005
    ..Thus the dioecious species Palmer amaranth and waterhemp may not necessarily hybridize with each other more readily than they would to one or more of the monoecious Amaranthus species...
  8. ncbi The antimicrobial screening of a Barbadian medicinal plant with indications for use in the treatment of diabetic wound infections
    S Carrington
    Faculty of Medical Sciences, The University of the West Indies, Cave Hill, Barbados
    West Indian Med J 61:861-4. 2012
    ..It was therefore tested against the bacteria Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, and Enterococcus feacalis (clincal strain) which are commonly found in diabetic wounds...
  9. ncbi Water stress and nitrogen limitation effects on corn (Zea mays L.) competition with a C3 and a C4 weed
    E Zand
    Department of Weed Research, Plant Pest and Disease Research Institute, P O Box 19395 1454, Tehran, Iran
    Commun Agric Appl Biol Sci 71:753-60. 2006
    ..Totally, it was concluded that drought stress and nitrogen deficiency, as the two results of climate change, had more negative effect on C3 weeds compared with C4...
  10. ncbi Interference of redroot pigweed (Amaranthus retroflexus L.) in green bean (Phaseolus vulgaris L.)
    B Mirshekari
    Islamic Azad University of Tabriz, Faculty of Agriculture, Department of Agronomy and Plant Breeding, Iran
    Commun Agric Appl Biol Sci 71:775-80. 2006
    ..Obviously, farmers with using of such experiment results could control weeds in the best time and with decreasing of herbicide use, we can move toward some purposes of the sustainable agriculture...
  11. ncbi Redroot pigweed
    Richard W Weber
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Ann Allergy Asthma Immunol 89:A6. 2002
  12. ncbi Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes
    Vaqar Mustafa Adhami
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Clin Cancer Res 9:3176-82. 2003
    Sanguinarine, derived from the root of Sanguinaria canadensis and other poppy fumaria species, possesses strong antimicrobial, anti-inflammatory, and antioxidant properties...
  13. doi Rise and fall of oral health products with Canadian bloodroot extract
    Christian Vlachojannis
    Institut fur Rechtsmedizin, Universitat Freiburg, Freiburg, Germany
    Phytother Res 26:1423-6. 2012
    The rhizome of Sanguinaria canadensis (SC, bloodroot) contains an active principle with antimicrobial, antiinflammatory, antioxidative and immunomodulatory effects...
  14. pmc Signals can trump rewards in attracting seed-dispersing ants
    Kyle M Turner
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e71871. 2013
    ..ants quickly collected diaspores (seeds plus elaiosomes) of Asarum canadense, Trillium grandiflorum, and Sanguinaria canadensis, but largely neglected those of T. erectum...
  15. doi Bloodroot
    Michael Z Wang
    Medical School, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
    Dermatitis 23:281-3. 2012
    BLOODROOT (Sanguinaria canadensis) is a flowering herb that can be used as a drug. Historically, it was widely used by Native Americans in blood tonification and purification, pain and fever relief, and wound healing...
  16. ncbi Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer
    Shana McDaniel
    Division of Dermatology, University of Vermont College of Medicine, Fletcher Allen Health Care, Burlington, VT 05401, USA
    Arch Dermatol 138:1593-6. 2002
    ..Zinc chloride and Sanguinaria canadensis (bloodroot) are 2 agents that are used as part of the Mohs chemosurgery fixed-tissue technique...
  17. ncbi Suppression of angiogenesis by the plant alkaloid, sanguinarine
    Jong Pil Eun
    Department of Neurosurgery, Chonbuk National University Hospital, Jeonju 560 180, Republic of Korea
    Biochem Biophys Res Commun 317:618-24. 2004
    Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis...
  18. ncbi Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery
    Vaqar Mustafa Adhami
    Department of Dermatology, University of Wisconsin Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Ther 3:933-40. 2004
    ..Sanguinarine, an alkaloid derived from the bloodroot plant Sanguinaria canadensis, has been shown to possess antimicrobial, anti-inflammatory, and antioxidant properties...
  19. ncbi Description of Lutzomyia (Helcocyrtomyia) tolimensis, a new species of phlebotomine sandfly (Diptera: Psychodidae) from Colombia
    María C Carrasquilla
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    Mem Inst Oswaldo Cruz 107:993-7. 2012
    ..A description is presented of Lutzomyia tolimensis sp. nov., a new species of the subgenus Helcocyrtomyia, series sanguinaria. It was collected in dwellings, peridomestic environment and in nearby forest patches located in the foothills ..
  20. doi Rapid human melanoma cell death induced by sanguinarine through oxidative stress
    Ana Burgeiro
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Eur J Pharmacol 705:109-18. 2013
    Sanguinarine is a natural isoquinoline alkaloid derived from the root of Sanguinaria canadensis and from other poppy fumaria species, and is known to have a broad spectrum of pharmacological properties...
  21. ncbi The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis
    Sandra M Newton
    The School of Pharmacy, University of Bradford, BD7 1DP, West Yorkshire, UK
    J Ethnopharmacol 79:57-67. 2002
    ..aurum were comparable with those against M. bovis BCG with compound (2) being the most active (M. bovis BCG, IC(50)=14.3 microg/ml [37.3 microM]). These results support the use of these plants in traditional medicine...
  22. ncbi Decoupling of light intensity effects on the growth and development of C3 and C4 weed species through sucrose supplementation
    Sultan H Begna
    Plant Science Department, McGill University, Macdonald Campus, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    J Exp Bot 53:1935-40. 2002
    ....
  23. ncbi Death from metastatic basal cell carcinoma: herbal remedy or just unlucky?
    Donald R Laub
    J Plast Reconstr Aesthet Surg 61:846-8. 2008
  24. doi Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation
    Min Ho Han
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan, South Korea
    Chemotherapy 54:157-65. 2008
    Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis, which induces apoptosis in human cancer cells, but the underlying action mechanisms are not completely understood...
  25. pmc In vitro screening for the tumoricidal properties of international medicinal herbs
    Elizabeth A Mazzio
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, Florida 32307, USA
    Phytother Res 23:385-98. 2009
    ..kingdom (LC(50) = 31-490 microg/mL) in order of the lowest LC(50) Dioscorea villosa (Dioscoreaceae) > Sanguinaria canadensis (Papaveraceae) > Dipsacus asper (Dipsacaceae) > Populus balsamifera (Salicaceae) > ..
  26. ncbi Screening for soil streptomycetes from North Jordan that can produce herbicidal compounds
    Sereen M B Bataineh
    Department of Applied Biological Sciences, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid
    Pol J Microbiol 57:297-305. 2008
    ....
  27. doi Phytotoxicity evaluation of five pharmaceutical pollutants detected in surface water on germination and growth of cultivated and spontaneous plants
    Brigida D'Abrosca
    Department of Life Sciences, Second University of Naples, Caserta, Italy
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:285-94. 2008
    ....
  28. ncbi Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3
    Woo Young Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Yangjung Dong, Busanjin Gu, Busan 614 714, South Korea
    Anticancer Res 29:4457-65. 2009
    Sanguinarine is a benzophenanthridine alkaloid, derived from the root of Sanguinaria canadensis and other poppy Fumaria species, which is known to have antimicrobial, antiinflammatory and antioxidant properties...
  29. doi Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature
    Anna M Moran
    Department of Pathology, Penn State University, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 35:404-6. 2008
    ..To the best of our knowledge, the histological features following use of bloodroot (Sanguinaria canadensis) have not yet been documented.
  30. ncbi Human blood mononuclear cell in vitro cytokine response before and after two different strenuous exercise bouts in the presence of bloodroot and Echinacea extracts
    David S Senchina
    Department of Biology, Drake University, Des Moines, IA 50311, USA
    Blood Cells Mol Dis 43:298-303. 2009
    ..90 min of cycling at 85% of ventilatory threshold [VT]) when stimulated in vitro with extracts from bloodroot (Sanguinaria canadensis), coneflower (Echinacea tennesseensis), or solvent vehicle controls...
  31. ncbi Description of Lutzomyia velezi, a new species of phlebotomine sand fly (Diptera: Psychodidae) from the Department of Antioquia, Colombia
    Eduar Elías Bejarano
    Grupo de Investigaciones Biomédicas, Universidad de Sucre, Colombia
    Mem Inst Oswaldo Cruz 105:322-5. 2010
    ..The new species belongs to the series sanguinaria of the subgenus Helcocyrtomyia, which is represented in Colombia by Lutzomyia cirrita, Lutzomyia hartmanni, ..
  32. ncbi Fluorescence of sanguinarine: spectral changes on interaction with amino acids
    Marika Janovska
    Laboratory of Biophysics, Faculty of Sciences, Palacky University, Tr 17 listopadu 12, CZ 77146 Olomouc, Czech Republic
    Phys Chem Chem Phys 12:11335-41. 2010
    ..We have also demonstrated that spectral change analysis can aid investigation of SG/DHSG interactions with proteins and we were able to identify SG(+)-binding site on Na(+)/K(+)-ATPase...
  33. doi An Internet misadventure: bloodroot salve toxicity
    John J Cienki
    Division of Emergency Medicine, Jackson Memorial Hospital and Miler School of Medicine, University of Miami, Miami, FL 33136, USA
    J Altern Complement Med 16:1125-7. 2010
    Bloodroot (Sanguinaria canadensis) is a perennial flowering plant native to North America. Sanguinarine, a benzylisoquinoline alkaloid, is a powerful escharotic contained in the root...
  34. ncbi The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus
    Brice W Obiang-Obounou
    Wonkwang University, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Jeonbuk 570 749, Korea
    J Toxicol Sci 36:277-83. 2011
    Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It is known to perform a wide spectrum of biological activities...
  35. doi Consequences of intratumoral injection of a herbal preparation containing blood root (Sanguinaria canadensis) extract in two dogs
    Michael O Childress
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
    J Am Vet Med Assoc 239:374-9. 2011
    2 dogs were referred for surgical removal of cutaneous tumors that had previously been treated by intratumoral injection of a herbal preparation containing blood-root (Sanguinaria canadensis) extract.
  36. ncbi Clinical effect of a Mexican sanguinaria extract (Polygonum aviculare L.) on gingivitis
    M Gonzalez Begne
    Dental Research Center, School of Dentistry, Allende Ote 151 3, Villas de San Agustin, Bo de Santa Cruz, Metepec, C P 52149, Edo de Mexico, Mexico
    J Ethnopharmacol 74:45-51. 2001
    ..Therefore, the effectiveness of a natural Mexican Sanguinaria extract (Polygonum aviculare L...
  37. doi Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study
    M F Bordet
    Boiron, Sainte Foy Les Lyon, France
    Homeopathy 97:10-5. 2008
    ..There is great controversy concerning treatment for menopausal symptoms. We evaluated homeopathic treatments for hot flushes and their effect on quality of life in menopausal women...
  38. doi Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL
    Shin Kim
    Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu 700 712, South Korea
    J Cell Biochem 104:895-907. 2008
    Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species, possessing potent antibacterial, antifungal, and anti-inflammatory activities...
  39. ncbi Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro
    Suk Jin Hong
    Department of Preventive Dentistry, College of Dentistry, Kyungpook National University, Daegu, Korea
    Int Dent J 55:128-32. 2005
    The purpose of this study was to investigate the potential cariostatic benefits of dentifrice containing both fluoride (F) and sanguinaria (SG) in a silica abrasive formula using the microbial de- and re-mineralisation cycle model.
  40. ncbi Photosynthetic and growth responses of zea mays L and four weed species following post-emergence treatments with mesotrione and atrazinet
    J Earl Creech
    Utah State University, Plants, Soils, and Biometeorology Department, 4820 Old Main Hill, Logan, UT 84322 4820, USA
    Pest Manag Sci 60:1079-84. 2004
    ..Shoot dry mass of broadleaf weeds was significantly reduced by all three herbicide treatments, except for A retroflexus treated with mesotrione alone...
  41. ncbi Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability
    R Jaggi
    VitaPlant AG, Benkenstrasse 254, 4108 Witterswil, Switzerland
    Inflamm Res 53:150-7. 2004
    ..N and its constituents, the inhibition of the synthesis of Leukotriene B4 (LTB4) and Prostaglandin (PGE2) by 5-lipoxygenase (5-LOX) and cyclo-oxygenase 1 and 2 (COX 1 and 2) respectively were examined in vitro...
  42. ncbi Uptake and release of cesium-137 by five plant species as influenced by soil amendments in field experiments
    Mark Fuhrmann
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    J Environ Qual 32:2272-9. 2003
    ....
  43. ncbi Forest edges and fire ants alter the seed shadow of an ant-dispersed plant
    J H Ness
    Institute of Ecology, University of Georgia, Athens, GA 30602 2202, USA
    Oecologia 138:448-54. 2004
    ..Both appear detrimental to ant-dispersed plants such as bloodroot, Sanguinaria canadensis...
  44. ncbi Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment
    Pavel Kosina
    Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic
    Food Chem Toxicol 42:85-91. 2004
    b>Sanguinaria canadesis, Chelidonium majus and Macleya cordata have been used for centuries as alternative medicines...
  45. ncbi Allelopathic potential and chemical constituents of volatiles from Ageratum conyzoides under stress
    Chuihua Kong
    Institute of Tropical and Subtropical Ecology, South China Agricultural University, Guangzhou
    J Chem Ecol 28:1173-82. 2002
    ..cichoracearum or exposed to A. gossypii feeding inhibited or killed fungi and insects. Precocenes and their derivatives, monoterpenes, and sesquiterpenes were the major volatile components of A. conyzoides...
  46. ncbi Uptake of cesium-137 and strontium-90 from contaminated soil by three plant species; application to phytoremediation
    Mark Fuhrmann
    Environmental and Waste Technology Group, Brookhaven National Lab, Upton, NY 11973 5000, USA
    J Environ Qual 31:904-9. 2002
    ..Uptake of 90Sr exhibits no relationship to 90Sr concentrations in the soil. Estimates of time required for removal of 50% of the two contaminants, assuming two crops of redroot pigweed per year, are 7 yr for 90Sr and 18 yr for 137Cs...
  47. ncbi Capillary electrophoresis of phytochemical substances
    Leena Suntornsuk
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudhaya Road, Rajathevee, Bangkok, Thailand
    J Pharm Biomed Anal 27:679-98. 2002
    ..990). Quantitation of sanguinarine and chelerythrine, alkaloids from Sanguinaria canadensis L. or Macleaya cordata (Wild) Br. R. by CE showed excellent linearity (R(2)>0...
  48. ncbi Escharotic and other botanical agents for the treatment of skin cancer: a review
    Nathaniel Jellinek
    Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Am Acad Dermatol 53:487-95. 2005
  49. ncbi Testing your diagnostic skills. Case no. 1: epithelial dysplasia
    Ron Baughman
    Todays FDA 18:20, 22. 2006
  50. ncbi Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production
    Jiiang Huei Jeng
    Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
    Atherosclerosis 191:250-8. 2007
    Sanguinarine is a plant alkaloid present in the root of Sanguinaria canadensis and Poppy fumaria species. Sanguinarine has been used as an antiseptic mouth rinse and a toothpaste additive to reduce dental plaque and gingival inflammation...
  51. ncbi Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms
    Daniel Jancula
    Centre for Cyanobacteria and Their Toxins, Institute of Botany, Academy of Sciences of the Czech Republic, Květná 8, 603 65 Brno, Czech Republic
    Environ Toxicol 22:480-6. 2007
    ..Dicranostigma lactucoides and Sanguinaria canadensis featured the highest toxicity while Macleaya microcarpa was found to be the least toxic to all ..
  52. ncbi Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt
    Min Ho Han
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan, South Korea
    Anticancer Drugs 18:913-21. 2007
    Sanguinarine is a benzophenanthridine alkaloid that is derived from the root of Sanguinaria canadensis and other poppy fumaria species, and is known to have antimicrobial, antiinflammatory and antioxidant properties...
  53. ncbi Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix
    Giuseppina Basini
    Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti, Sezione di Fisiologia Veterinaria, Universita di Parma, Parma, Italy
    Biofactors 29:11-8. 2007
    ..The identification of possible ways to block blood vessels formation has become a major scientific objective of the last decade and several phytochemicals are currently being exploited to target tumour angiogenesis...
  54. ncbi Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Biological and Medical Research, Riyadh 11211, Saudi Arabia
    Cancer Res 67:3888-97. 2007
    ..block proliferation of PEL cells, we found that sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell proliferation and induces apoptosis in a dose-dependent manner in several PEL cell ..
  55. ncbi Sanguinarine inhibits VEGF-induced Akt phosphorylation
    Giuseppina Basini
    Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti, Sezione di Fisiologia, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    Ann N Y Acad Sci 1095:371-6. 2007
    ..Sanguinarine (SA), an alkaloid isolated from Sanguinaria canadensis, is known for its antiangiogenetic effects by suppressing basal and VEGF-induced new vessel growth...
  56. ncbi HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae
    Jana Suchomelová
    Department of Biochemistry, Faculty of Medicine, Masaryk University, Komenskeho nam 2, CZ 662 43 Brno, Czech Republic
    J Pharm Biomed Anal 44:283-7. 2007
    ..SR) and macarpine (MA) was determined in the underground part of six plant species of the family Papaveraceae (Sanguinaria canadensis L., Dicranostigma lactucoides HOOK.f.et THOMS, Chelidonium majus L., Macleaya cordata (Willd...
  57. ncbi The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis
    Giuseppina Basini
    Department of Animal Production, Veterinary Biotechnology, Food Safety and Quality Veterinary Physiology, University of Parma, Italy
    J Reprod Dev 53:573-9. 2007
    Sanguinarine (SA), a phytobiotic from Sanguinaria Canadensis, has been demonstrated to inhibit vessel growth...
  58. ncbi Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization
    Mei Chi Chang
    Biomedical Science Team, Chang Gung Institute of Technology, Taoyuan, Taiwan
    Toxicol Appl Pharmacol 218:143-51. 2007
    Sanguinarine is a benzopheanthridine alkaloid present in the root of Sanguinaria canadensis L. and Chellidonium majus L...
  59. ncbi Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 363:203-8. 2001
    Sanguinarine, an alkaloid from Sanguinaria canadensis, has no effect on the yeast Saccharomyces cerevisiae at concentrations of up to 225 microM...

Research Grants8

  1. CHEMOPREVENTION OF PROSTATE CANCER BY SANGUINARINE
    Nihal Ahmad; Fiscal Year: 2002
    ..Sanguinarine, derived from the root of Sanguinaria canadendid, is a benzophenanthridine alkaloid that is believed to posses anti-tumor properties...
  2. Skin Cancer Chemoprevention by Sanguinarine
    Nihal Ahmad; Fiscal Year: 2003
    ..Sanguinarine, derived from the root of Sanguinaria canadensis and other poppy-fumaria species, has been shown to possess anti-microbial, antioxidant and anti-..
  3. Skin Cancer Chemoprevention by Sanguinarine
    Nihal Ahmad; Fiscal Year: 2004
    ..Sanguinarine, derived from the root of Sanguinaria canadensis and other poppy-fumaria species, has been shown to possess anti-microbial, antioxidant and anti-..
  4. CHEMOPREVENTION OF PROSTATE CANCER BY SANGUINARINE
    Nihal Ahmad; Fiscal Year: 2001
    ..Sanguinarine, derived from the root of Sanguinaria canadendid, is a benzophenanthridine alkaloid that is believed to posses anti-tumor properties...
  5. EVALUATION OF BOTANICALS FOR H .PYLORI INFECTIONS
    Gail Mahady; Fiscal Year: 2002
    ..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..
  6. Conference on Emerging Research Technologies
    Gail Mahady; Fiscal Year: 2004
    ....
  7. Botanicals for Chlamydia pneumonia infections-Revision 1
    Gail Mahady; Fiscal Year: 2005
    ..Data and active standardized extracts developed during this work will be used as the basis for future clinical trials. ..
  8. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    ..Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well. ..