glycyrrhiza

Summary

Summary: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivatives, CARBENOXOLONE for example. Licorice toxicity is manifested as hypokalemia, low blood potassium. Licorice is used as flavoring and aromatic in pharmaceuticals and as candy.

Top Publications

  1. ncbi [Toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis with Tripterygium wilfordii]
    Ya Song Li
    Zhejiang Provincial Hospital of TCM, Hangzhou
    Zhongguo Zhong Xi Yi Jie He Za Zhi 26:1117-9. 2006
  2. ncbi Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots
    Hidemasa Nagai
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 59:1421-6. 2007
  3. doi Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    Marjan Nassiri Asl
    Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
    Phytother Res 22:709-24. 2008
  4. ncbi Memory enhancing activity of Glycyrrhiza glabra in mice
    Dinesh Dhingra
    Pharmacology Division, Department of Pharmaceutical Sciences, P O Box 38, Guru Jambheshwar University, Hisar 125001, Haryana, India
    J Ethnopharmacol 91:361-5. 2004
  5. ncbi Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice
    Minpei Kuroda
    Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Bioorg Med Chem Lett 13:4267-72. 2003
  6. ncbi Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells
    Eun Hye Jo
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, Seoul 151 742, South Korea
    Cancer Lett 230:239-47. 2005
  7. ncbi Antiviral effects of Glycyrrhiza species
    Cristina Fiore
    Department of Medical and Surgical Sciences Endocrinology, University of Padua, Padova, Italy
    Phytother Res 22:141-8. 2008
  8. doi Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa
    Nicole Wittschier
    University of Munster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D 48149 Munster, Germany
    J Ethnopharmacol 125:218-23. 2009
  9. ncbi Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 322:263-70. 2004
  10. ncbi Licorice and cancer
    Z Y Wang
    American Health Foundation, New York, NY 10017, USA
    Nutr Cancer 39:1-11. 2001

Research Grants

  1. Oramelts with DGL: Treatment of Minor RAU
    Michael Martin; Fiscal Year: 2004
  2. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2006
  3. Research CAMP: Research in Complementary and Alternative Medicine Program
    Heather Zwickey; Fiscal Year: 2007
  4. Discovery of Anticancer Agents of Diverse Natural Orgin
    ALAN KINGHORN; Fiscal Year: 2007
  5. Microbial Outcomes of Minimal Intervention Treatment
    Mathilde Peters; Fiscal Year: 2005
  6. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
  7. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2003

Detail Information

Publications242 found, 100 shown here

  1. ncbi [Toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis with Tripterygium wilfordii]
    Ya Song Li
    Zhejiang Provincial Hospital of TCM, Hangzhou
    Zhongguo Zhong Xi Yi Jie He Za Zhi 26:1117-9. 2006
    ..To investigate the toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis (RA) with Tripterygium wilfordii (TW)...
  2. ncbi Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots
    Hidemasa Nagai
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 59:1421-6. 2007
    Licochalcone A, a species-specific and characteristic retrochalcone ingredient of Glycyrrhiza inflata root, has been shown to possess multiple bioactive properties. However, its muscle relaxant activity has not been reported previously...
  3. doi Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    Marjan Nassiri Asl
    Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
    Phytother Res 22:709-24. 2008
    The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener...
  4. ncbi Memory enhancing activity of Glycyrrhiza glabra in mice
    Dinesh Dhingra
    Pharmacology Division, Department of Pharmaceutical Sciences, P O Box 38, Guru Jambheshwar University, Hisar 125001, Haryana, India
    J Ethnopharmacol 91:361-5. 2004
    In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (family: Leguminosae) have been employed clinically for centuries for their anti-inflammatory, antiulcer, expectorant, antimicrobial and anxiolytic ..
  5. ncbi Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice
    Minpei Kuroda
    Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Bioorg Med Chem Lett 13:4267-72. 2003
    The EtOAc extract of licorice (Glycyrrhiza uralensis roots) exhibited considerable PPAR-gamma ligand-binding activity...
  6. ncbi Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells
    Eun Hye Jo
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, Seoul 151 742, South Korea
    Cancer Lett 230:239-47. 2005
    Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root, Glycyrrhiza uralensis (G...
  7. ncbi Antiviral effects of Glycyrrhiza species
    Cristina Fiore
    Department of Medical and Surgical Sciences Endocrinology, University of Padua, Padova, Italy
    Phytother Res 22:141-8. 2008
    Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis...
  8. doi Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa
    Nicole Wittschier
    University of Munster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D 48149 Munster, Germany
    J Ethnopharmacol 125:218-23. 2009
    Aqueous extracts from the roots of Glycyrrhiza glabra L. (Fabaceae) are widely used for treatment of stomach ulcer. The clinical proven effects are related to the presence of anti-inflammatory 12-keto-triterpensaponins in the extracts...
  9. ncbi Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 322:263-70. 2004
    ..These findings provide mechanistic explanation for LA activity and suggest that it may be considered as a chemopreventive agent and its anticancer properties should be further explored...
  10. ncbi Licorice and cancer
    Z Y Wang
    American Health Foundation, New York, NY 10017, USA
    Nutr Cancer 39:1-11. 2001
    ..Licorice polyphenols induce apoptosis in cancer cells. These and other activities of licorice are reviewed, and a rationale is suggested for combinations of agents in preventive clinical trials...
  11. pmc Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)
    Rudy Simons
    Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands
    Anal Bioanal Chem 401:305-13. 2011
    The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene...
  12. doi Antimicrobial potential of Glycyrrhiza glabra roots
    Vivek K Gupta
    Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR, Kukrail Picnic Spot Road, P O CIMAP, Lucknow 226015, India
    J Ethnopharmacol 116:377-80. 2008
    The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration...
  13. doi 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice
    Zhiyuan Zhu
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    J Neurochem 114:374-85. 2010
    ..Here, we reported that the natural product 2,2',4'-trihydroxychalcone (TDC) from Glycyrrhiza glabra functioned as a specific non-competitive inhibitor against BACE1 enzyme, and potently repressed beta-..
  14. ncbi Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root
    Sijun Dong
    Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Food Chem Toxicol 45:2470-8. 2007
    b>Glycyrrhiza glabra root is one of the common traditional Chinese medicines and used as flavoring and sweetening agents for tobaccos, chewing gums, candies, toothpaste and beverages...
  15. ncbi Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra)
    Young Won Chin
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 55:4691-7. 2007
    ..4'-O-methylglabridin, and paratocarpin B) (3-9) were isolated from the roots and stolons of licorice (Glycyrrhiza glabra)...
  16. doi Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L
    Prabhjit Kaur
    Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India
    Toxicol In Vitro 23:680-6. 2009
    ..In search for lead molecules in cancer chemoprevention from natural products, a fraction 'Rlicca' isolated from Glycyrrhiza glabra was studied for modulatory effect against hydrogen peroxide and 4-nitroquinoline-N-oxide induced ..
  17. ncbi Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 91:147-55. 2004
    ..Therefore, we suggest the use of glb with or without E2 as a new agent for modulation of vascular injury and atherogenesis for the prevention of cardiovascular diseases in post-menopausal women...
  18. ncbi Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine
    L A Baltina
    Institute of Organic Chemistry Ufa Research Centre of RAS, 71 Prospect Oktyabrya, Ufa, 450054, Russian Federation
    Curr Med Chem 10:155-71. 2003
    Glycyrrhizic Acid (GL) is the major bioactive triterpene glycoside of licorice root (Glycyrrhiza Radix) extracts possessing a wide range of pharmacological properties (anti-inflammatory, anti-ulcer, anti-allergic, anti-dote, anti-oxidant,..
  19. doi Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice
    Yong Ming Cui
    College of Life Science and Technology, Institute of Resource Biology and Biotechnology, Huazhong University of Science and Technology, Wuhan, P R China
    Planta Med 74:377-80. 2008
    Glabridin was isolated from the roots of Glycyrrhiza glabra and its effects on cognitive functions and cholinesterase activity were investigated in mice. Glabridin (1, 2 and 4 mg kg (-1), P. O.) and piracetam (400 mg kg (-1), i. p...
  20. ncbi Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Nutrition 18:268-73. 2002
    ..In the present study, we extended our investigation to analyze the antiatherogenic effects of licorice-root extract consumption in moderately hypercholesterolemic patients...
  21. ncbi Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models
    Milind Parle
    Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, Haryana, India
    J Med Food 7:462-6. 2004
    In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities...
  22. ncbi In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
    Licorice (Glycyrrhiza glabra L., Leguminosae) is frequently used in traditional medicine to treat inflammatory and allergic diseases...
  23. doi Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™)
    C V Chandrasekaran
    R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
    Regul Toxicol Pharmacol 61:373-80. 2011
    b>Glycyrrhiza glabra Linn. (licorice) is widespread throughout the Mediterranean region and certain areas of Asia...
  24. ncbi Chemoprofile and bioactivities of Taverniera cuneifolia (Roth) Arn.: a wild relative and possible substitute of Glycyrrhiza glabra L
    Gajanan B Zore
    School of Life Sciences, SRTM University, Nanded, Maharashtra, India
    Phytomedicine 15:292-300. 2008
    Chemoprofile of Taverniera cuneifolia (Roth) Arn. a wild relative of commercial licorice (Glycyrrhiza glabra L) is presented. Both T. cuneifolia and G. glabra L were found to be very similar phytochemically...
  25. doi Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
    Yan Jing Li
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
    J Chromatogr A 1218:8181-91. 2011
    Licorice, derived from the dried roots and rhizomes of several species of genus Glycyrrhiza L. (Leguminosae family), has been traditionally used in herbal medicine for over 4000 years...
  26. ncbi Variability in the content of active constituents and biological activity of Glycyrrhiza glabra
    Giancarlo A Statti
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi della Calabria, Via Pietro Bucci, I 87036 Arcavacata di Rende CS, Italy
    Fitoterapia 75:371-4. 2004
    Nine samples of Glycyrrhiza glabra were collected in various sites of Calabria, Italy, with the aim to determine the variability in the confront of active constituents and in antibacterial and antifungal activities of the extracts...
  27. ncbi Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata
    Yongming Cui
    College of Life Science and Technology, Institute of Resource Biology and Biotechnology, Huazhong University of Science and Technology, Wuhan 430074, China
    Z Naturforsch C 63:361-5. 2008
    Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests...
  28. ncbi Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia
    In Koo Hwang
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, Korea
    Acta Pharmacol Sin 27:959-65. 2006
    ..To observe neuroprotective effects of raw and roasted licorice against hypoxia and ischemic damage...
  29. doi Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A--induced damages on testes in mature rats
    Hassan Malekinejad
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
    Hum Exp Toxicol 30:110-23. 2011
    The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats...
  30. ncbi Cytotoxic allyl retrochalcone from the roots of Glycyrrhiza inflata
    Goo Yoon
    College of Pharmacy and Drug Development Research Institute, Chonnam National University, Gwangju 501 757, Korea
    Chem Pharm Bull (Tokyo) 53:694-5. 2005
    ..one new retrochalcone, licochalcone E (4) were isolated by cytotoxicity-guided fractionation from the roots of Glycyrrhiza inflata along with an ordinary chalcone, isoliquiritigenin (3)...
  31. ncbi Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information
    Kenji Kondo
    Botanical Raw Materials Research Dept, Tsumura and Co, Ibaraki, Japan
    Biol Pharm Bull 30:1271-7. 2007
    Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, and G...
  32. doi Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents
    P Thiyagarajan
    Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, 19th K M Stone, Hosur Road, Bangalore 560100, India
    Inflammopharmacology 19:235-41. 2011
    To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators.
  33. doi In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action
    Mannanthendil Kumaran Asha
    R and D Centre, Natural Remedies Pvt Ltd, Bangalore, Karnataka, India
    J Ethnopharmacol 145:581-6. 2013
    b>Glycyrrhiza glabra Linn. is regarded useful for peptic ulcer in traditional systems of medicine in India and Helicobacter pylori has been considered as one of the causative factors for peptic ulcer...
  34. doi Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin
    Atiya Fatima
    Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR, Kukrail Picnic Spot Road, P O CIMAP, Lucknow 226015, India
    Phytother Res 23:1190-3. 2009
    Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi...
  35. ncbi Influence of drought on oxidative stress and flavonoid production in cell suspension culture of Glycyrrhiza inflata Batal
    Ying Yang
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Z Naturforsch C 62:410-6. 2007
    ..and physiological parameters characteristic for oxidative stress were studied in a cell suspension culture of Glycyrrhiza inflata Batal to investigate its drought tolerance...
  36. doi Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice
    Ying Kai Hong
    Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, PR China
    Int J Biol Macromol 45:61-4. 2009
    The purpose of this study was to investigate the immune and antioxidant activities of Glycyrrhiza glabra polysaccharides (GGP) in rats fed high-fat diet. The experiment was performed on four groups of growing Kunming mice...
  37. doi Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves--chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity
    Laura Siracusa
    Istituto del C N R di Chimica Biomolecolare, Via Paolo Gaifami, 18 I 95126 Catania, Italy
    Fitoterapia 82:546-56. 2011
    Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity...
  38. ncbi Phylogenetic relationship of six Glycyrrhiza species based on rbcL sequences and chemical constituents
    H Hayashi
    Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 23:602-6. 2000
    The nucleotide sequences of ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit gene (rbcL) of Glycyrrhiza glabra, G. uralensis, G. inflata, G. echinata, G. macedonica and G...
  39. doi Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models
    Nishant P Visavadiya
    BRD School of Biosciences, Sardar Patel Maidan, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India
    Int J Food Sci Nutr 60:135-49. 2009
    The aim of present study was to evaluate antioxidant property of Glycyrrhiza glabra root extracts using in vitro models...
  40. ncbi Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats
    Nishant P Visavadiya
    Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India
    Mol Nutr Food Res 50:1080-6. 2006
    The hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (GG) root powder were examined in hypercholesterolaemic male albino rats...
  41. ncbi [The anti-respiratory syncytial virus effect of active compound of Glycyrrhiza GD4 in vitro]
    Xiu Qin Wang
    Public Health College of Harbin Medical University, China
    Zhong Yao Cai 29:692-4. 2006
    To study the effect on anti-respiratory syncytial virus of an active compound GD4 from Glycyrrhiza in vitro.
  42. ncbi In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice)
    Xue Qing Yu
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Life Sci 82:68-78. 2008
    ..Glabridin, a major flavonoid of Glycyrrhiza glabra (licorice), possesses multiple pharmacological activities...
  43. ncbi Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin
    R A Isbrucker
    Burdock Group, 888 17th Street, NW, Suite 810 Washington, DC 20006, USA
    Regul Toxicol Pharmacol 46:167-92. 2006
    ..Based on the in vivo and clinical evidence, we propose an acceptable daily intake of 0.015-0.229 mg glycyrrhizin/kg body weight/day...
  44. ncbi A history of the therapeutic use of liquorice in Europe
    Cristina Fiore
    Department of Medical and Surgical Sciences, Endocrinology, University of Padua, Via Ospedale 105, 35128 Padua, Italy
    J Ethnopharmacol 99:317-24. 2005
    ..Finally, a comparison between traditional use in and outside Europe, with the most important recent scientific studies concerning its use, is presented...
  45. ncbi Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract
    H Wagner
    Department of Pharmacy, Center of Pharma Research, Institut of Pharmaceutical Biology, University of Munich, Germany
    Phytomedicine 9:390-7. 2002
    A phytopharmaceutical containing an extract of Echinacea purpurea and Glycyrrhiza glabra root (Revitonil tablets) was investigated for its suggested immunostimulating potential, using several in vitro tests and the in vivo carbon-..
  46. doi The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats
    Kazuhisa Honda
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    Anim Sci J 80:562-9. 2009
    Licorice (Glycyrrhiza glabra) has been widely used in traditional medicines, and its flavonoid oil (LFO) decreases abdominal adipose tissue weight in mammals...
  47. ncbi Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 91:241-6. 2004
    ..Glabrene activity was not inhibited by raloxifene. Therefore, glabridin shows greater similarity to estradiol-17beta and thus greater potential, with or without Vitamin D, to modulate bone disorders in post-menopausal women...
  48. ncbi The effect of an endogenous antioxidant glabridin on oxidized LDL
    Eli Carmeli
    Department of Physical Therapy, Sackler Faculty of Medicine, The Stanley Steyer School of Health Professions, Tel Aviv University, Ramat Aviv, Israel
    J Basic Clin Physiol Pharmacol 19:49-63. 2008
    ..We conclude that the dietary consumption of glabridin can partially protect LDL from oxidation...
  49. ncbi Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice
    Dinesh Dhingra
    Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
    J Med Food 9:281-3. 2006
    ..The present study was undertaken to estimate the acetylcholinesterase- inhibiting activity of extracts of Glycyrrhiza glabra, Myristica fragrans seeds, and ascorbic acid and compare these values with a standard ..
  50. ncbi Estrogen-like activity of glabrene and other constituents isolated from licorice root
    S Tamir
    Laboratory of Natural Compounds for Medicinal Use, Migal-Galilee Technological Center, 10200, Kiryat Shmona, Israel
    J Steroid Biochem Mol Biol 78:291-8. 2001
    ..This is the first study to indicate that glabrene, an isoflavene exerted varying degrees of ER agonism in different tissues...
  51. ncbi Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats
    Hiroshi Kamisoyama
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan
    Biosci Biotechnol Biochem 72:3225-31. 2008
    Licorice flavonoid oil (LFO), which contains hydrophobic flavonoids from Glycyrrhiza glabra LINNE, is a new ingredient for functional foods. In this study, we investigated the anti-obesity action of LFO in diet-induced obese rats...
  52. doi A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts
    Rudy Simons
    Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Rapid Commun Mass Spectrom 23:3083-93. 2009
    ..ethanol, ethanol and ethyl acetate extract of the roots of Glycyrrhiza glabra indicated the presence of 70 mono- and di-prenylated flavonoids...
  53. doi Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes
    Zenji Kawakami
    Tsumura Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Eur J Pharmacol 626:154-8. 2010
    ..Among the seven constituent herbs of yokukansan, significant effects were found for glycyrrhiza. Furthermore, glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid (10(-7)-10(-4)M), among the eight ..
  54. doi 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats
    K Nakagawa
    Functional Food Ingredients Division, Healthcare Products Business Unit, Kaneka Corporation, 3 2 4, Nakanoshima, Kita ku, Osaka 530 8288, Japan
    Food Chem Toxicol 46:2349-57. 2008
    ..Based on these findings, it is concluded that the no-observed-adverse-effect level (NOAEL) for the LFO concentrate solution is estimated to be 800 mg/kg/day for female rats, and approximately 400 mg/kg/day for male rats...
  55. doi Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity
    Minpei Kuroda
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1, Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Bioorg Med Chem 18:962-70. 2010
    Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10)...
  56. ncbi [Hypertension due to liquorice and liquorice tea consumption]
    H Boganen
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Huisartsgeneeskunde, divisie Klinische Methoden en Public Health, Amsterdam
    Ned Tijdschr Geneeskd 151:2825-8. 2007
    ..5 mg a day. This means no more than 10-30 g liquorice and no more than half a cup of liquorice tea a day. --On diagnosing hypertension, the effects of liquorice and liquorice tea consumption on blood pressure should be kept in mind...
  57. doi Genotoxicity studies on licorice flavonoid oil (LFO)
    K Nakagawa
    Functional Food Ingredients Division, Healthcare Products Business Unit, Kaneka Corporation, 3 2 4, Nakanoshima, Kita ku, Osaka 530 8288, Japan
    Food Chem Toxicol 46:2525-32. 2008
    ..From the findings obtained from the genotoxicity assays performed in this study and the published pharmacokinetic studies of LFO, it appears unlikely that dietary consumption of LFO will present any genotoxic hazard to humans...
  58. ncbi Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans
    Fumiki Aoki
    Functional Food Ingredients Division, Kaneka Corporation, 1 8 Miyamae machi, Takasago, Hyogo 676 8688, Japan
    J Am Coll Nutr 26:209-18. 2007
    ..Glabridin is one of the bioactive flavonoids included specifically in licorice Glycyrrhiza glabra L. and is the most abundant flavonoid in LFO...
  59. ncbi Absorption of dietary licorice isoflavan glabridin to blood circulation in rats
    Chinatsu Ito
    Laboratory of Food and Nutritional Chemistry, Graduate School of Agriculture, Kobe University, Kobe, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:358-65. 2007
    ..Thus, dietary glabridin was at least partly incorporated into the body in an unchanged form, though most dietary flavonoids are converted to non-active conjugate forms during intestinal absorption...
  60. ncbi Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice
    Kaku Nakagawa
    Functional Foods Development Division, Kaneka Corporation, Osaka, Japan
    Biol Pharm Bull 27:1775-8. 2004
    Licorice, the root of the Glycyrrhiza species, is one of the most frequently employed botanicals in traditional medicines...
  61. ncbi Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation
    T K Shetty
    Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Phytother Res 16:576-8. 2002
    The radioprotective effect of the root extract of Glycyrrhiza glabra L on lipid peroxidation in rat liver microsomes and plasmid pBR322 DNA was investigated...
  62. doi Estimation of dietary intake of ochratoxin A from liquorice confectionery
    M Herrera
    Veterinary Faculty, University of Zaragoza, C Miguel Servet 177, E 50013 Zaragoza, Spain
    Food Chem Toxicol 47:2002-6. 2009
    ..Risk assessment in a worst case scenario (children high consumers and maximum content of OTA) represented 8.94% TWI by liquorice confectionery alone...
  63. ncbi Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice
    Fumiki Aoki
    Functional Food Ingredients Division, Kaneka Corporation, Japan
    Biosci Biotechnol Biochem 71:206-14. 2007
    ..These findings suggest that LFO prevented and ameliorated diet-induced obesity via the regulation of lipid metabolism-related gene expression in the liver...
  64. ncbi Ochratoxin A in liquorice as affected by processing methods
    A Arino
    Veterinary Faculty, University of Zaragoza, C Miguel Servet 177, E 50013 Zaragoza, Spain
    Food Addit Contam 24:987-92. 2007
    ..1% reduction). A great reduction in the OTA level was found during the production of liquorice extract (78.6%) and block liquorice (91.8%)...
  65. ncbi The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans
    Julie Brush
    Helfgott Research Institute, National College of Naturopathic Medicine, Portland, OR, USA
    Phytother Res 20:687-95. 2006
    ..The ability of three herbs, Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, to activate immune cells in human subjects was assessed in this pilot study...
  66. ncbi Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages
    Jin Kyung Kim
    Food and Drug Preclinical Technology Innovation Center, Hallym University, Gangwon Do, Republic of Korea
    Biochem Biophys Res Commun 345:1215-23. 2006
    Licorice, the roots of Glycyrrhiza inflata, is used by practitioners of alternative medicine to treat individuals with gastric or duodenal ulcers, bronchitis, cough, arthritis, adrenal insufficiency, and allergies...
  67. doi Blockade of nitroxidative stress by roasted licorice extracts in high glucose-exposed endothelial cells
    Yean Jung Choi
    Department of Food and Nutrition and Korean Institute of Nutrition, BK 21, Hallym University, Chuncheon, Korea
    J Cardiovasc Pharmacol 52:344-54. 2008
    ..5 mM and 33 mM glucose for 5 d in the absence and presence of 1 to 20 mug/mL roasted licorice (Glycyrrhiza inflata Bat.) ethanol extracts (rLE)...
  68. ncbi Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer
    Chang Ki Lee
    Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute and Brain Korea 21 Project, Yonsei University College of Dentistry, 134 Shinchon dong, Seodaemoon ku, Seoul, Korea
    Biol Pharm Bull 30:2191-5. 2007
    ..Therefore, the licorice extract may be a candidate for an anticancer and chemopreventive agent. However, cancer patients with cisplatin therapy should avoid the supplementation of the licorice extract...
  69. ncbi Dihydrostilbene derivatives from Glycyrrhiza glabra leaves
    Daniela M Biondi
    Istituto del C N R di Chimica Biomolecolare, Sezione di Catania, Via del Santuario 110, I 95028 Valverde CT, Italy
    J Nat Prod 68:1099-102. 2005
    ..pinocembrin 7-O-glucoside, astragalin, isoquercitrin, vicenin II, and the inositol, pinitol, were isolated from the leaves of Glycyrrhiza glabra grown in Sicily. The structures of 1-4 were elucidated by spectroscopic methods.
  70. ncbi Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from Glycyrrhiza inflata
    Goo Yoon
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju 500 757, Korea
    Arch Pharm Res 30:313-6. 2007
    Licochalcones A (1) and E (2), retrochalcones or reversely constructed chalcones, isolated from the roots of Glycyrrhiza inflata, were evaluated for their cytotoxicities against four different human tumor cell lines; A549 (lung), SK-OV-3 ..
  71. ncbi The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study
    Heather Zwickey
    Helfgott Research Institute, National College of Natural Medicine, Portland, OR 97201, USA
    Phytother Res 21:1109-12. 2007
    ..on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination...
  72. ncbi Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 74:624-9. 2003
    Antinephritis activity of glabridin, a pyranoisoflavan isolated from Glycyrrhiza glabra, was evaluated after its oral administration to mice with glomerular disease (Masugi-nephritis) by measuring the urinary protein excretion, total ..
  73. ncbi Pharmaceutical evaluation of liquorice before and after roasting in mice
    Takami Majima
    Division of Pharmacognosy, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:589-95. 2004
    ..It is notable that oral administration of the high molecular mass fraction (Fa) significantly inhibited IgE-mediated ear swelling six days after challenge at doses as low as 3, 15 or 75 mg x kg(-1)...
  74. ncbi cDNA cloning and expression of isoflavonoid-specific glucosyltransferase from Glycyrrhiza echinata cell-suspension cultures
    Shigeyuki Nagashima
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, 108 8641 Tokyo, Japan
    Planta 218:456-9. 2004
    ..UDP-glucose: formononetin 7- O-glucosyltransferase, designated UGT73F1, was cloned from yeast extract-treated Glycyrrhiza echinata L...
  75. doi Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products
    C V Chandrasekaran
    R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
    Phytomedicine 18:278-84. 2011
    b>Glycyrrhiza glabra and its phytoconstituents have been known to possess widespread pharmacological properties as an anti-inflammatory, anti-viral, antitumour and hepatoprotective drug...
  76. doi Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl(4))-induced hepatocyte damage in common carp (Cyprinus carpio)
    Guojun Yin
    Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, China
    Fish Physiol Biochem 37:209-16. 2011
    The present study is aiming at evaluating the hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract (2.5, 5 and 10 μg/ml) on the carbon tetrachloride (CCl(4))-induced carp hepatocyte damage in vitro...
  77. pmc The sweet cake that reaches parts other cakes can't!
    R M Hussain
    Integrated Department of General Medicine, Pontefract General Infirmary, Friarwood Lane, Pontefract, West Yorkshire WF8 1PL, UK
    Postgrad Med J 79:115-6. 2003
    ..This case highlights the importance of asking about herbal remedies when taking a drug history in all patients, including those admitted as medical emergencies...
  78. doi A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia
    Hai Ning Yuan
    Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Beijing, China
    J Clin Psychopharmacol 28:264-370. 2008
    ..This study was designed to compare the herbal preparation called Peony-Glycyrrhiza Decoction (PGD) with bromocriptine (BMT), a dopamine agonist widely used for PRL-secreting disorders, in the ..
  79. ncbi Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression
    Hye Gwang Jeong
    Department of Pharmacy and Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Kwangju 501 759, South Korea
    Pharmacol Res 46:221-7. 2002
    ....
  80. ncbi Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography
    Yue Jiang
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1033:183-6. 2004
    Glycyrrhizin is one of the main bioactive components in liquorice (Glycyrrhiza uralensis Fisch) which has recently been found to be highly active in inhibiting replication of the severe acute respiratory syndrome (SARS)-associated virus...
  81. ncbi Anti-Helicobacter pylori flavonoids from licorice extract
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Life Sci 71:1449-63. 2002
    ..Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G...
  82. ncbi Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:617-22. 2007
    ..Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer...
  83. ncbi In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots
    Alice Friis-Møller
    Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark
    Planta Med 68:416-9. 2002
    ..gormanii and L. micdadei were inhibited by licochalcone A 500 - 1000 mg/l. These data indicate that licochalcone A might be of interest as a new class of antibacterial drug in the treatment of severe lung-infections...
  84. ncbi Flavonoids from Glycyrrhiza pallidiflora hairy root cultures
    Wei Li
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Phytochemistry 60:351-5. 2002
    ..formononetin 7-O-(6"-malonylglucoside) and 2'-hydroxyformononetin 7-O-glucoside were isolated from Glycyrrhiza pallidiflora hairy root cultures. Their structures were determined on the basis of spectroscopic evidence...
  85. ncbi Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots
    Jung Ho Choi
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun dong, Yusong gu, Daejeon 305 333, Republic of Korea
    J Ethnopharmacol 110:563-6. 2007
    ..6 microM and decreased cholesteryl ester formation with an IC(50) value of 26.0 microM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT...
  86. ncbi [Studies on flavonoids extraction technology from Glycyrrhiza inflata and their bacteriostatic activities]
    Yong Ming Cui
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Zhong Yao Cai 29:838-41. 2006
    To study the extraction technique for the flavonoids from Glycyrrhiza inflata and their bacteriostatic bioactivities.
  87. ncbi Glycyrrhizin
    Gerhard Eisenbrand
    DFG Senate Commission on Food Safety, Scientific Office, Lebensmittelchemie und Umwelttoxikologie, Technische Universitat Kaiserslautern, Erwin Schrödinger Str, D 67663 Kaiserslautern, Germany
    Mol Nutr Food Res 50:1087-8. 2006
  88. ncbi In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites
    Rea Krausse
    Institute of Medical Microbiology and Virology, University Hospital Schleswig Holstein, Campus Kiel, Brunswiker Str 4, 24105 Kiel, Germany
    J Antimicrob Chemother 54:243-6. 2004
    ....
  89. ncbi Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients
    Hidetaka Sasaki
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Tex 77555 0435, USA
    Pathobiology 70:229-36. 2002
    ..These results indicate that GR has the potential to inhibit NSI-HIV replication in patient PBMC cultures by inducing the production of beta-chemokines...
  90. ncbi Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract
    Jeffrey A Burgess
    Department of Oral Medicine of University of Washington School of Dentistry, Seattle, WA, USA
    J Contemp Dent Pract 9:88-98. 2008
    The aim of this article is to present a review of over-the-counter (OTC) treatment strategies used for aphthous ulcerations and to provide results from the use of an herbal extract containing glycyrrhiza.
  91. ncbi Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products
    Cesare Sabbioni
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Phytochem Anal 17:25-31. 2006
    Glycyrrhizin (1), the main active principle of Glycyrrhiza glabra (liquorice) roots, is extensively used in herbal medicines, in pharmaceutical preparations and confectionery products...
  92. ncbi Topical devices for atopic dermatitis: what is the data behind these new products?
    Kendra Gail Bergstrom
    J Drugs Dermatol 6:956-8. 2007
  93. ncbi Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin
    Lucia Rackova
    Institute of Experimental Pharmacology Slovak Academy of Sciences, Bratislava, Slovak Republic
    Nat Prod Res 21:1234-41. 2007
    ..of liposomal membrane, and inhibitory effect on whole blood reactive oxygen species (ROS) liberation of Glycyrrhiza glabra crude extract and glycyrrhizin, its major compound, were assessed...
  94. ncbi A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, United States
    Food Chem Toxicol 46:310-20. 2008
    ....
  95. ncbi [Properties of commercial licorice extracts used as a food additive]
    Kenji Iida
    Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Shokuhin Eiseigaku Zasshi 48:112-7. 2007
    ..3 to 5.0%, and ammonium nitrogen ranged from 0.03 to 2.5%. These results indicated that various products were distributed on the market. Differences in the manufacturing process may contribute to the variations of product properties...
  96. ncbi Analysis of glycyrrhizic acid and liquiritin in liquorice root with microwave-assisted micellar extraction and pre-concentration
    Chen Sun
    Chemistry and Chemical Engineering Department, Graduate University of Chinese Academy of Sciences, Beijing 100049, People s Republic of China
    Phytochem Anal 19:160-3. 2008
    ....
  97. ncbi [Optimizing the best extraction condition of semi-bionic extraction for licorice by unifrom design]
    Yan Qin Cheng
    401th Hospital of PLA, Qingdao 266071, China
    Zhong Yao Cai 30:598-601. 2007
    ..To optimize the best extraction condition of semi-bionic extraction for licorice...
  98. ncbi Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats
    Yun Lian Lin
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Phytother Res 22:69-76. 2008
    ..study investigated whether a combination regimen of Salvia miltiorrhiza (S), Ligusticum chuanxiong (L) and Glycyrrhiza glabra (G) exerted in vivo antifibrotic effects on rats with hepatic fibrosis...
  99. ncbi Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix
    Lianyu Guo
    Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yeonkun dong, Jongno Ku, Seoul 110 460, South Korea
    J Ethnopharmacol 113:306-11. 2007
    A complex formula composed of Paeonia lactiflora PALL. and Glycyrrhiza uralensis Fisch...
  100. ncbi Field survey of Glycyrrhiza plants in Central Asia (3). Chemical characterization of G. glabra collected in Uzbekistan
    Hiroaki Hayashi
    Gifu Pharmaceutical University, Mitahora Higashi, Gifu, Japan
    Chem Pharm Bull (Tokyo) 51:1338-40. 2003
    The chemical characteristics of Glycyrrhiza glabra L. were investigated at a habitat in Uzbekistan. HPLC analysis of the underground parts indicated that glycyrrhizin contents varied from 3.3 to 6...
  101. ncbi A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats
    Tatsumasa Mae
    Functional Foods Development Division, Life Science RD Center, Kaneka Corporation, Takasago, Hyogo 676 8688, Japan
    J Nutr 133:3369-77. 2003
    ..In this study, we showed that nonaqueous fractions of licorice (Glycyrrhiza uralensis Fisher) extracted with ethanol, ethyl acetate and acetone, but not an aqueous extract, had PPAR-gamma ..

Research Grants19

  1. Oramelts with DGL: Treatment of Minor RAU
    Michael Martin; Fiscal Year: 2004
    ..DGL is a water extract of glycyrrhiza (licorice root) with acids and related salts mostly removed...
  2. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2006
    ..Proof of the successful prediction of the structures of 20-30 hypothetical members of the SCOR proteome could provide a model for the prediction of protein folding on the basis of as little as 20% sequence homology. ..
  3. Research CAMP: Research in Complementary and Alternative Medicine Program
    Heather Zwickey; Fiscal Year: 2007
    ....
  4. Discovery of Anticancer Agents of Diverse Natural Orgin
    ALAN KINGHORN; Fiscal Year: 2007
    ....
  5. Microbial Outcomes of Minimal Intervention Treatment
    Mathilde Peters; Fiscal Year: 2005
    ..This investigation is a clinical and molecular re-entry study of sealing of caries, in support of a future full-scale clinical trial of incomplete caries removal. ..
  6. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
    ....
  7. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2003
    ..Proof of the successful prediction of the structures of 20-30 hypothetical members of the SCOR proteome could provide a model for the prediction of protein folding on the basis of as little as 20% sequence homology. ..