combretum

Summary

Summary: A plant genus of the family COMBRETACEAE. Triterpenes and combretastatin have been identified in members of this genus.

Top Publications

  1. ncbi Anti-HIV activity against immunodeficiency virus type 1 (HIV-I) and type II (HIV-II) of compounds isolated from the stem bark of Combretum molle
    Kaleab Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 43:15-20. 2005
  2. ncbi The inhibition of Clostridium chauvoei (jakari strain) neuraminidase activity by methanolic extracts of the stem barks of Tamarindus indicus and Combretum fragrans
    N M Useh
    Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
    J Enzyme Inhib Med Chem 19:339-42. 2004
  3. ncbi Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice
    Evelise F Pietrovski
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal do Parana, Curitiba, 88015 420, PR, Brazil
    Pharmacol Biochem Behav 83:90-9. 2006
  4. ncbi Poisoning in ostriches following ingestion of toxic plants--field observations
    Ross G Cooper
    Department of Physiology, College of Health Sciences, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe, Africa
    Trop Anim Health Prod 39:439-42. 2007
  5. doi The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens
    V Naidoo
    Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, South Africa
    Vet Parasitol 153:214-9. 2008
  6. pmc Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
    Olivier M Vandeputte
    Plant Biotechnology Unit, BioVallée, 8 rue Adrienne Bolland, B 6041 Gosselies, Belgium
    Appl Environ Microbiol 76:243-53. 2010
  7. pmc Inhibitory and bactericidal potential of crude acetone extracts of Combretum molle (Combretaceae) on drug-resistant strains of Helicobacter pylori
    Collise Njume
    Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, P Bag X1314, Alice 5700, South Africa
    J Health Popul Nutr 29:438-45. 2011
  8. doi Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats
    Aminu Chika
    Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Ali Akilu Road, Sokoto, Nigeria
    J Ethnopharmacol 129:34-7. 2010
  9. pmc Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum
    Igor A Schepetkin
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59717, USA
    Int Immunopharmacol 15:628-37. 2013
  10. ncbi Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)
    N D Martini
    Programme for Phytomedicine, Department of Paraclinical Sciences, University of Pretoria, Pretoria 0002, South Africa
    J Ethnopharmacol 93:207-12. 2004

Scientific Experts

Detail Information

Publications96

  1. ncbi Anti-HIV activity against immunodeficiency virus type 1 (HIV-I) and type II (HIV-II) of compounds isolated from the stem bark of Combretum molle
    Kaleab Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 43:15-20. 2005
    In vitro anti-HIV activity of various extracts prepared from the stem bark of Combretum molle (R. Br. Ex. G. Don...
  2. ncbi The inhibition of Clostridium chauvoei (jakari strain) neuraminidase activity by methanolic extracts of the stem barks of Tamarindus indicus and Combretum fragrans
    N M Useh
    Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
    J Enzyme Inhib Med Chem 19:339-42. 2004
    ..Extracts of two medicinal plants, Tamarindus indicus and Combretum fragrans at 100-1000 microg/ml, both significantly reduced the activity of the enzyme in a dose-dependent ..
  3. ncbi Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice
    Evelise F Pietrovski
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal do Parana, Curitiba, 88015 420, PR, Brazil
    Pharmacol Biochem Behav 83:90-9. 2006
    ..extract (EE) and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in chemical and thermal behavioural models of pain in mice. The EE (10-1000 mg/kg) given orally (p.o...
  4. ncbi Poisoning in ostriches following ingestion of toxic plants--field observations
    Ross G Cooper
    Department of Physiology, College of Health Sciences, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe, Africa
    Trop Anim Health Prod 39:439-42. 2007
    ..Ingestion of Combretum oatesii (Red wings) seeds from plants in free grazing pastures resulted in vomiting, restlessness, eyelid ..
  5. doi The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens
    V Naidoo
    Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, South Africa
    Vet Parasitol 153:214-9. 2008
    ..b>Combretum woodii (160 mg/kg) proved to be extremely toxic to the birds, while treatment with Tulbaghia violacea (35 g/kg), ..
  6. pmc Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
    Olivier M Vandeputte
    Plant Biotechnology Unit, BioVallée, 8 rue Adrienne Bolland, B 6041 Gosselies, Belgium
    Appl Environ Microbiol 76:243-53. 2010
    ..In this report, extracts of leaves and bark of Combretum albiflorum (Tul.) Jongkind (Combretaceae) were found to quench the production of QS-dependent factors in P...
  7. pmc Inhibitory and bactericidal potential of crude acetone extracts of Combretum molle (Combretaceae) on drug-resistant strains of Helicobacter pylori
    Collise Njume
    Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, P Bag X1314, Alice 5700, South Africa
    J Health Popul Nutr 29:438-45. 2011
    ..pylori and a reference strain-NCTC 11,638-was evaluated against five solvent extracts of Combretum molle, a plant widely used for the treatment of gastric ulcers and other stomach-related morbidities in South ..
  8. doi Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats
    Aminu Chika
    Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Ali Akilu Road, Sokoto, Nigeria
    J Ethnopharmacol 129:34-7. 2010
    To investigate antidiabetic effect of the leaves of Combretum micranthum G. Don, a medicinal plant used for treating diabetes in Northwestern Nigeria.
  9. pmc Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum
    Igor A Schepetkin
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59717, USA
    Int Immunopharmacol 15:628-37. 2013
    Extracts of leaves of different species of the genus Combretum have been used historically to treat a variety of medicinal problems. However, little is known about the active components conferring therapeutic properties to these extracts...
  10. ncbi Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)
    N D Martini
    Programme for Phytomedicine, Department of Paraclinical Sciences, University of Pretoria, Pretoria 0002, South Africa
    J Ethnopharmacol 93:207-12. 2004
    Preliminary studies with Combretum erythrophyllum showed antimicrobial activity against Gram-positive and Gram-negative bacteria. Seven antibacterial flavonoids were subsequently isolated by bioassay-guided fractionation, i.e...
  11. ncbi Ethnobotanical and antimicrobial investigation on some species of Terminalia and Combretum (Combretaceae) growing in Tanzania
    P Fyhrquist
    Department of Pharmacy, Division of Pharmacognosy, Viikki Biocenter, PO Box 56, FIN 00014 University of Helsinki, Helsinki, Finland
    J Ethnopharmacol 79:169-77. 2002
    An ethnobotanical investigation on the medicinal uses of some species of Terminalia and Combretum (Combretaceae) was carried out in Mbeya, Tanzania during a 5-weeks field expedition. Of the sixteen species collected, Combretum fragrans F...
  12. ncbi Cardiovascular effects of mollic acid glucoside, a 1alpha-hydroxycycloartenoid saponin extractive from Combretum molle R Br ex G Don (Combretaceae) leaf
    J A Ojewole
    Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu Natal, Durban, South Africa
    Cardiovasc J Afr 19:128-34. 2008
    The cardiovascular effects of mollic acid glucoside (MAG), a 1alpha-hydroxycycloartenoid saponin extractive from Combretum molle R Br ex G Don (Combretaceae) leaf, have been investigated in some experimental animal paradigms...
  13. ncbi Analgesic and antiinflammatory effects of mollic acid glucoside, a 1 alpha-hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf
    John A O Ojewole
    Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu Natal, Private Bag X54001, Durban 4000, South Africa
    Phytother Res 22:30-5. 2008
    ..and antiinflammatory properties of mollic acid glucoside (MAG), a 1 alpha-hydroxycycloartenoid extract from Combretum molle leaf, have been investigated in mice and rats...
  14. ncbi Sugars in the gut of the sandfly Phlebotomus orientalis from Dinder National Park, Eastern Sudan
    J G Hamilton
    Chemical Ecology Group, Centre for Applied Entomology and Parasitology, Department of Biological Sciences, School of Life Sciences, Keele University, Staffordshire, UK
    Med Vet Entomol 14:64-70. 2000
    ..compared these with sugars from several potential local plant sources: Acacia seyal, Balanites aegyptiaca and Combretum kordofanum. The distribution of these trees in Sudan is closely correlated with that of P. orientalis...
  15. ncbi A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
    J N Eloff
    Department of Pharmacology, University of Pretoria, South Africa
    Planta Med 64:711-3. 1998
    ..Using S. aureus, and a Combretum molle extract, the technique was 32 times more sensitive than agar diffusion techniques and was not sensitive to ..
  16. ncbi Associations of Phlebotomus orientalis and other sandflies with vegetation types in the eastern Sudan focus of kala-azar
    D A Elnaiem
    Department of Zoology, University of Khartoum, Sudan
    Med Vet Entomol 13:198-203. 1999
    ..orientalis was more abundant in forests dominated by Acacia seyal than where Combretum kordofanum, Balanites aegyptiaca, Hyphaena thaibaica or Ziziphus spinachristi were the dominant trees...
  17. doi Alternate hosts of African cassava mosaic virus and East African cassava mosaic Cameroon virus in Nigeria
    Olufemi J Alabi
    Department of Plant Pathology, Washington State University, Irrigated Agriculture Research and Extension Center, 24106 N Bunn Rd, Prosser, WA 99350, USA
    Arch Virol 153:1743-7. 2008
    ..Senna occidentalis, Leucana leucocephala and Glycine max), castor oil plant (Ricinus communis), a weed host (Combretum confertum) and a wild species of cassava (Manihot glaziovii) were determined...
  18. ncbi Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines
    P Fyhrquist
    Division of Clinical Chemistry and Folkhälsan Research Center, Institute for Preventive Nutrition, Medicine and Cancer, Biomedicum, P O Box 63, FIN 00014 University of Helsinki, Finland
    Fitoterapia 77:358-66. 2006
    Methanolic extracts (25 microug/ml) of species belonging to the genera of Combretum, Terminalia and Pteleopsis, collected during a field expedition in Tanzania in 1999, were screened for their antiproliferative and cytotoxic effects ..
  19. pmc Cytotoxic activity of selected Nigerian plants
    A Sowemimo
    Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine Campus, Idi Araba, Lagos
    Afr J Tradit Complement Altern Med 6:526-8. 2009
    ..leaves showed activity comparable to the reference compound Cisplatin and greater cytotoxic activity than Combretum paniculatum, Celosia trigyna, Drymaria cordata, Cyathula achyranthoides and Cyathula prostata...
  20. ncbi Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich
    L S Lopes
    Centro de Ciencias da Saude, Universidade Federal do Piaui, Teresina, PI, Brasil
    Braz J Med Biol Res 43:1184-92. 2010
    Previous studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare...
  21. doi The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Pharmacol Exp Ther 335:302-13. 2010
    Combretastatin-A4 (CA-4) is a natural derivative of the African willow tree Combretum caffrum. CA-4 is one of the most potent antimitotic components of natural origin, but it is, however, intrinsically unstable...
  22. doi In vitro antiplasmodial activity of some medicinal plants of Burkina Faso
    Lamoussa Paul Ouattara
    Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208, Ouagadougou 01, Burkina Faso, France
    Parasitol Res 113:405-16. 2014
    ..activity was found for extracts from: the alkaloid leaf extract and the chloromethylenic extracts of Combretum fragrans (IC50 = 3 μg/ml, IC50 = 5 μg/ml), the total alkaloids and the chloromethylenic leaf ..
  23. doi Establishing high temperature gas chromatographic profiles of non-polar metabolites for quality assessment of African traditional herbal medicinal products
    Nicaise F Bony
    Groupe de Chimie Analytique de Paris Sud, EA4041 IFR141, Faculte de Pharmacie, Univ Paris Sud, 5 Rue Jean Baptiste Clement, 92296 Chatenay Malabry Cedex, France Département de Chimie Analytique, Chimie Minérale et Générale, Technologie Alimentaire, Unité de Formation et de Recherche UFR des sciences pharmaceutiques et biologiques, Université d Abidjan Cocody, 01 BP V 34 Abidjan, Cote d Ivoire
    J Pharm Biomed Anal 88:542-51. 2014
    ..assessment of chromatographic profiles of non-polar metabolites issued from several batches of leaves of Combretum micranthum and Mitracarpus scaber by high temperature gas chromatography coupled to mass spectrometry, performed ..
  24. doi Acetylated dammarane-type bisdesmosides from Combretum inflatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 76:1592-7. 2013
    The first study of the chemical constituents of Combretum inflatum has resulted in the isolation of seven new acetylated dammarane-type bisdesmosides (1-7)...
  25. doi Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell
    Neuza B Barros
    Fundação Oswaldo Cruz FIOCRUZ RONDÔNIA, Porto Velho, RO, Brazil Electronic address
    Exp Parasitol 135:337-43. 2013
    ..a liposomal formulation containing lupane [3β,6β,16β-trihydroxylup-20(29)-ene], isolated from fruits of Combretum leprosum with pharmacological properties as antinociceptive, anti-inflammatory, antiulcerogenic and ..
  26. ncbi Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity
    H Ali
    Institut fur Pharmazeutische Biologie, University of Bonn, Nussallee 6, D 53115 Bonn, Germany
    J Ethnopharmacol 83:219-28. 2002
    ..6 microg/ml (stems) and 0.7 microg/ml (leaves). Extracts of different parts of Combretum hartmannianum (Combretaceae) possessed significant activity against the chloroquine-sensitive P...
  27. ncbi Phytochemical and antifungal activities of Uvaria. chamae leaves and roots, Spondias mombin leaves and bark and Combretum racemosum leaves
    O M T B Okwuosa
    Department of Medical Laboratory Sciences, Nnamdi Azikiwe University, Awka Nnewi Campus, Nigeria
    Afr J Med Med Sci 41:99-103. 2012
    ..methanolic and n-hexane extracts of Uvaria chamae (roots and leaves), Spondias mombin (leaves and bark) and Combretum racemosum (Leaves), on pathogenic candida albicans and aspergillus niger was studied...
  28. doi The use of a rat model to evaluate the in vivo toxicity and wound healing activity of selected Combretum and Terminalia (Combretaceae) species extracts
    Peter Masoko
    Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
    Onderstepoort J Vet Res 77:E1-7. 2010
    ..study was undertaken to determine the safety and efficacy of the topical treatment of acetone leaf extracts of Combretum imberbe, Combretum nelsonii,Combretum albopuntactum and Terminalia sericea based on their in vitro antimicrobial ..
  29. doi Combretum mucronatum and Capparis thonningii prevent scopolamine-induced memory deficit in mice
    Ismail Ogunbayode Ishola
    Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi Araba, Nigeria
    Pharm Biol 51:49-57. 2013
    Roots of Combretum mucronatum Schumach. & Thonn. (Combretaceae) and Capparis thonningii Schum. (Capparaceae) are used in southwest Nigeria in the treatment of inflammatory disorders and mental illness.
  30. doi Bioactivities of the genus Combretum (Combretaceae): a review
    Gedson Rodrigues de Morais Lima
    Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051 970, PB, Brazil
    Molecules 17:9142-206. 2012
    ..Some Combretum species are extensively used in traditional medicine against inflammation, infections, diabetes, malaria, ..
  31. pmc Mechanisms of the antinociceptive action of (-) epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents
    Luciano da Silva Lopes
    NPPM Medicinal Plants Research Center, Health Sciences Center, Federal University of Piauí UFPI, Av Nossa Senhora de Fátima s n, 64049 550, Teresina, PI, Brazil
    J Biomed Sci 19:68. 2012
    ..The mechanisms of the antinociceptive activity of (-) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher...
  32. doi Chemometrics and vibrational spectroscopy as green tools for mine phytoremediation strategies
    N S Mokgalaka-Matlala
    Tshwane University of Technology, Department of Chemistry, Private Bag X680, Pretoria 0001, South Africa
    Spectrochim Acta A Mol Biomol Spectrosc 100:138-43. 2013
    This study describes the use of near infrared (NIR) spectroscopy in combination with chemometrics to characterise Combretum erythrophyllum plant material to determine differences in the chemical profiles of samples harvested from mine ..
  33. doi Determination of potentially toxic heavy metals in traditionally used medicinal plants for HIV/AIDS opportunistic infections in Ngamiland District in Northern Botswana
    Harriet Okatch
    Department of Chemistry, University of Botswana, Gaborone, Botswana
    Anal Chim Acta 730:42-8. 2012
    ..plants; Dichrostachys cinerea, Maerua angolensis, Mimusops zeyheri, Albizia anthelmintica, Plumbago zeylanica, Combretum imberbe, Indigofera flavicans, Clerodendrum ternatum, Solanum panduriforme, Capparis tomentosa, Terminalia ..
  34. ncbi Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage
    Sanaa M Nabha
    Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:2735-41. 2002
    ..combretastatin-A4 prodrug (CA4P), anantitubulin/antiangiogenic agent isolated from the South African willow tree Combretum caffrum, induced cell death primarily through mitotic catastrophe in a panel of human B-lymphoid tumors...
  35. doi In vitro antioxidant and radical scavenging of Guinean kinkeliba leaf (Combretum micranthum G. Don) extracts
    Alhassane Touré
    State Key Laboratory of the School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, P R China
    Nat Prod Res 25:1025-36. 2011
    The antioxidant properties of the water and ethanol leaf extracts of kinkeliba (Combretum micranthum) were investigated, including scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (IC₅₀ values: 8.02 ± 0...
  36. doi Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4
    Jie Zhou
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Asian Nat Prod Res 13:330-40. 2011
    ..Compound 6a has shown the strongest potency against the tested human tumor cell lines with an IC₅₀ value ranging from submicromolar to micromolar level...
  37. pmc Detection of antimicrobial compounds by bioautography of different extracts of leaves of selected South African tree species
    M M Suleimana
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa
    Afr J Tradit Complement Altern Med 7:64-78. 2010
    The hexane, acetone, dichloromethane and methanol extracts of Combretum vendae A.E. van Wyk (Combretaceae), Commiphora harveyi (Engl.) Engl. (Burseraceae), Khaya anthotheca (Welm.) C.DC (Meliaceae), Kirkia wilmsii Engl...
  38. doi Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity
    Kazufumi Toume
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    J Nat Prod 74:249-55. 2011
    ..combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated...
  39. ncbi Developments of combretastatin A-4 derivatives as anticancer agents
    Y Shan
    Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi Province, 710061, PR China
    Curr Med Chem 18:523-38. 2011
    ..Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum...
  40. ncbi Arjunolic acid: a novel phytomedicine with multifunctional therapeutic applications
    Thiagarajan Hemalatha
    Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai 600 020, India
    Indian J Exp Biol 48:238-47. 2010
    ..It is a triterpenoid saponin, isolated earlier from Terminalia arjuna and later from Combretum nelsonii, Leandra chaeton etc. Arjunolic acid is a potent antioxidant and free radical scavenger...
  41. ncbi Cytotoxic pentacyclic triterpenoids from Combretum oliviforme
    Xiao peng Wu
    Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, China 571158
    Nat Prod Commun 5:1027-30. 2010
    Four pentacyclic triterpenoids were obtained from the leaves of Combretum oliviforme Chao, 3beta-hydroxyolean-12-en-28-oic acid (1), 23-O-[alpha-L-(4'-acetylrhamnopyranosyl)]-imberbic acid (2), 23-acetoxy-3beta-acetylimberbic acid-29-..
  42. ncbi The effect of supplementation with fresh browse of Ziziphus mauritiana or Combretum aculeatum on feed intake, nitrogen utilization and growth of grazing range sheep
    M Sangare
    Centre International de Recherche Développement sur l Elevage en zone Subhumide CIRDES, 01 Bobo Dioulasso 01, Burkina Faso, Ethiopia
    Trop Anim Health Prod 35:465-76. 2003
    The influence of 0, 60 or 120 min access to a grove of either Ziziphus mauritiana (Ziziphus) or Combretum aculeatum (Combretum) on forage intake and on the digestibility, growth and excretion of nutrients was determined using 40 Oudah ..
  43. doi Evaluation of selected South African plant species for antioxidant, antiplatelet, and cytotoxic activity
    M M Suleiman
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
    Pharm Biol 48:643-50. 2010
    The antioxidant, antiplatelet, and cytoxoxic effects of seven South African plant extracts, namely, Combretum vendae A.E. van Wyk (Combretaceae), Commiphora harveyi (Engl.) Engl. (Burseraceae), Khaya anthotheca (Welm.) C...
  44. doi In vivo antifungal effect of Combretum and Terminalia species extracts on cutaneous wound healing in immunosuppressed rats
    P Masoko
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Sciences, University of Pretoria, Onderstepoort, South Africa
    Pharm Biol 48:621-32. 2010
    Acetone leaf extracts of Combretaceae species Combretum imberbe Wawra, Combretum nelsonii Duemmer, Combretum albopunctatum Suesseng, and Terminalia sericea Burch ex DC and a mixture of asiatic acid and arjunolic acid isolated from C...
  45. ncbi Cyclobutanes from Combretum albopunctatum
    David R Katerere
    Department of Pharmaceutical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Phytochemistry 65:433-8. 2004
    A dichloromethane extract of the aerial parts of Combretum albopunctatum Suesseng afforded five phenolic compounds-three known flavonoids and two novel cyclobutane chalcone dimers...
  46. ncbi A new beta-D-glucopyranosyl 2-oxo-urs-12-en-28-oate from the Cameroonian plant Combretum bracteatum
    Germain Ntchatcho
    Dipartimento di Chimica Organica, Universita di Pavia, Via Taramelli 10, 27100 Pavia, Italy
    Nat Prod Commun 4:1631-6. 2009
    From the Cameroonian plant Combretum bracteatum (Laws.) Engl...
  47. doi Oxazole-bridged combretastatin A analogues with improved anticancer properties
    Bernhard Biersack
    Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95440 Bayreuth, Germany
    ChemMedChem 5:420-7. 2010
    ....
  48. ncbi Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin a-4
    M Marrelli
    Department of Pharmaceutical Sciences, University of Calabria, I 87036 Rende CS, Italy
    Curr Med Chem 18:3035-81. 2011
    ..antimitotic agent combretastatin A-4 (CA-4), a cis-stilbene natural product isolated from the South African tree Combretum caffrum Kuntze, is the lead compound of a new class of anti-cancer drugs that target tumor vasculature...
  49. doi Five new diarylpropan-1-ols from Combretum yunnanense
    Li Qin Wang
    Department of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, China
    Planta Med 77:1841-4. 2011
    ..combretol A-E (1- 5), together with one known coumarin (6) and ten known triterpenes (7-16), were isolated from Combretum yunnanense...
  50. doi Diarylpropanes and an arylpropyl quinone from Combretum griffithii
    Panawan Moosophon
    Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 74:2216-8. 2011
    ..5) were isolated from a methanol extract of stems of Combretum griffithii. Their structures were elucidated by spectroscopic methods...
  51. ncbi It is possible to use herbarium specimens to screen for antibacterial components in some plants
    J N Eloff
    Department of Pharmacology, University of Pretoria, South Africa
    J Ethnopharmacol 67:355-60. 1999
    The antibacterial activity of herbarium specimens of Combretum erythrophyllum growing in the Pretoria area and originally collected between 92 and 12 years ago were compared with freshly collected leaves...
  52. ncbi Hepatoprotective constituents of the seeds of Combretum quadrangulare
    I K Adnyana
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 23:1328-32. 2000
    Hepatoprotective effect of MeOH, MeOH-H2O (1:1) and H2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-alpha(TNF-alpha)-induced cell death in primary cultured mouse hepatocytes...
  53. ncbi Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants
    K Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia
    Phytother Res 15:62-9. 2001
    ..Six extracts made from the root bark of Bersama abyssinica Fresen, the leaves of Combretum paniculatum Vent., and Dodonaea angustifolia L.f., and the stem bark of Ximenia americana L...
  54. ncbi Targeting tumour vasculature: the development of combretastatin A4
    J Griggs
    Department of Biochemistry, University of Cambridge, UK
    Lancet Oncol 2:82-7. 2001
    ..This tubulin-binding agent was originally isolated from an African shrub, Combretum caffrum...
  55. pmc The biology of the combretastatins as tumour vascular targeting agents
    Gillian M Tozer
    Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Int J Exp Pathol 83:21-38. 2002
    ..CA-1 and CA-4 were isolated from the African bush willow, Combretum caffrum, and several synthetic analogues are also now available, such as the Aventis Pharma compound, AVE8062...
  56. ncbi Seasonal variations in the distribution and abundance of the tsetse fly, Glossina morsitans morsitans in eastern Zambia
    P van den Bossche
    Institute of Tropical Medicine, Veterinary Department, Antwerp, Belgium
    Med Vet Entomol 16:170-6. 2002
    ..Julbernardia dominant, and munga, a one- or two-storied woodland where the principal tree genera were Acacia, Combretum and Terminalia...
  57. ncbi Antimicrobial activity of some plants used for the treatment of livestock disease in the Eastern Cape, South Africa
    P J Masika
    ARDRI, University of Fort Hare, P Bag X 1314, 5700, Alice, South Africa
    J Ethnopharmacol 83:129-34. 2002
    ..Prominent among these plants are Combretum caffrum, Salix capensis and Schotia latifolia...
  58. ncbi Methyl gardenolate A, a novel cycloartenoid ester from the leaves of Combretum woodii (Combretaceae)
    Philip H Coombes
    Natural Products Research Group, School of Pure and Applied Chemistry, University of Natal, Durban, South Africa
    Nat Prod Lett 16:301-4. 2002
    ..gardenolate A (3a), together with gardenolic acid A (2a) and the unusual triterpenoid xi-glutinol (D:B-friedoolean-5-en-3xi-ol) (1a) from the leaves of Combretum woodii support its differentiation from the closely related C. krausii.
  59. ncbi Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis
    Yukihiro Asami
    Department of Biosciences, School of Science and Technology, Teikyo University, 1 1 Toyosatodai, Utsunomiya 320 8551, Japan
    J Nat Prod 66:729-31. 2003
    A new ellagic acid derivative (1) was isolated from the branches of Combretum yunnanensis, and its structure was assigned as 4-(4' '-O-acetyl-alpha-rhamnopyranosyl)ellagic acid by analysis of its spectral data...
  60. ncbi Cytotoxic pentacyclic triterpenes from Combretum nigricans
    G Simon
    Unibioscreen SA, EEBIC, 40 Av J Wybran, Brussels 1070, Belgium
    Fitoterapia 74:339-44. 2003
    ..triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2)...
  61. doi The biological activity and chemistry of the southern African Combretaceae
    J N Eloff
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    J Ethnopharmacol 119:686-99. 2008
    ..Many of these indications are related to treating infections. This contribution summarizes work done to date and identifies avenues for future research...
  62. pmc Aqueous and Organic Solvent-Extracts of Selected South African Medicinal Plants Possess Antimicrobial Activity against Drug-Resistant Strains of Helicobacter pylori: Inhibitory and Bactericidal Potential
    Collise Njume
    School of Biological and Environmental Sciences, Faculty of Science and Agriculture, University of Fort Hare, P Bag X1314, Alice 5700, South Africa E Mails C N A A J
    Int J Mol Sci 12:5652-65. 2011
    ..Solvent-extracts of selected medicinal plants; Combretum molle, Sclerocarya birrea, Garcinia kola, Alepidea amatymbica and a single Strychnos species were investigated ..
  63. doi Antimalarial herbal remedies of Msambweni, Kenya
    J M Nguta
    Department of Public Health, Pharmacology and Toxicology, University of Nairobi, PO Box 30197, Nairobi 00100, Kenya
    J Ethnopharmacol 128:424-32. 2010
    ..Tiliaceae), Canthium glaucum Hiern. (Rubiaceae), Amaranthus hybridus L. (Amaranthaceae), Combretum padoides Engl and Diels. (Combretaceae), Senecio syringitolius O. Hoffman...
  64. doi Anthelmintic screening of Sub-Saharan African plants used in traditional medicine
    Carrie Waterman
    Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, Philadelphia, PA 19104 4495, USA
    J Ethnopharmacol 127:755-9. 2010
    ....
  65. ncbi Evaluation of selected South African medicinal plants for inhibitory properties against human immunodeficiency virus type 1 reverse transcriptase and integrase
    Pascal Obong Bessong
    Department of Microbiology, University of Venda for Science and Technology, PMB X5050, Thohoyandou 0950, South Africa
    J Ethnopharmacol 99:83-91. 2005
    ..Fabaceae) (IC(50) 3.5 microg/ml), while the methanol extract of the roots of Combretum molle R.Br. ex G. Don (Combretaceae) was the most inhibitory on the ribonuclease H (RNase H) activity (IC(50) 9...
  66. doi Biological activity of two related triterpenes isolated from Combretum nelsonii (Combretaceae) leaves
    P Masoko
    Department of Paraclinical Sciences, Faculty of Veterinary Sciences, Phytomedicine Programme, University of Pretoria, Onderstepoort, South Africa
    Nat Prod Res 22:1074-84. 2008
    Antifungal bioassay-guided fractionation of Combretum nelsonii leaf extracts afforded two closely related triterpenes, asiatic acid and arjunolic acid...
  67. ncbi Pharmaceutical design of antimitotic agents based on combretastatins
    H P Hsieh
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    Curr Pharm Des 11:1655-77. 2005
    ..on the combretastatins, a group of antimitotic agents isolated from the bark of the South African willow tree Combretum caffrum Kuntz, is of considerable contemporary interest...
  68. ncbi Spatial decoupling of facilitation and competition at the origin of gapped vegetation patterns
    Nicolas Barbier
    Service de Botanique Systématique et Phytosociologie, Universite Libre de Bruxelles, Bruxelles, Belgium
    Ecology 89:1521-31. 2008
    ..The root systems of five individuals of Combretum micranthum G. Don were excavated...
  69. doi Screening of some Tanzanian medicinal plants from Bunda district for antibacterial, antifungal and antiviral activities
    Sheila Mgole Maregesi
    Department of Pharmacognosy, School of Pharmacy, Muhimbili University of Health and Allied Sciences MUHAS, P O Box 65013, Dar es Salaam, Tanzania
    J Ethnopharmacol 119:58-66. 2008
    ..Extracts from four plants; Lannea schweinfurthii, Combretum adenogonium, Ficus sycomorus and Terminalia mollis showed strong antiviral activity with RF values of 10(3) and ..
  70. ncbi Effect of burning on the numbers of questing ticks collected by dragging
    I G Horak
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa
    Onderstepoort J Vet Res 73:163-74. 2006
    ..was initiated, and six sub-plots, with identical histories, within each of two of the burn plot replicates in Combretum collinum/Combretum zeyheyri woodland on granite, were selected...
  71. ncbi Past and present vegetation ecology of Laetoli, Tanzania
    Peter Andrews
    Natural History Museum, Cromwell Road, London, SW7 5BD, UK
    J Hum Evol 54:78-98. 2008
    ..shallow brown soils on volcanic lavas have four woodland associations, two dominated by Acacia species, two by Combretum-Albizia species; shallow volcanic soils to the east have a woodland association with Croton-Dombeya-Albizia ..
  72. ncbi Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells
    Ilio Vitale
    Department of Biology, University Roma Tre, V le Marconi 446, 00146, Rome, Italy
    Apoptosis 12:155-66. 2007
    Combretastatin A-4 (CA-4), a natural stilbenoid isolated from Combretum caffrum, is a new vascular targeting agent (VTA) known for its antitumor activity due to its anti-tubulin properties...
  73. ncbi Antibacterial activity of Venda medicinal plants
    Vanessa Steenkamp
    Department of Pharmacology, University of Pretoria, South Africa
    Fitoterapia 78:561-4. 2007
    ..b>Combretum molle, Peltophorum africanum, Piper capense, Terminalia sericea and Zanthoxylum davyi were the most active and ..
  74. ncbi Fitness related diet-mixing by intraspecific host-plant-switching of specialist insect herbivores
    Karsten Mody
    Department of Animal Ecology and Tropical Biology, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    Ecology 88:1012-20. 2007
    ..The caterpillars switched regularly between host tree individuals (Combretum fragrans, Combretaceae)...
  75. ncbi Angiotensin-converting enzyme inhibition by Brazilian plants
    Fernão C Braga
    Faculdade de Farmacia, Universidade Federal de Minas Gerais, Av Antonio Carlos, Belo Horizonte, Brazil
    Fitoterapia 78:353-8. 2007
    ..The following plants presented significant ACE inhibition rates: Calophyllum brasiliense, Combretum fruticosum, Leea rubra, Phoenix roebelinii and Terminalia catappa.
  76. ncbi Microscopic morphology of Dichapetalum cymosum (Hook.) Engl. as an aid in the identification of leaf fragments from the digestive tract of poisoned animals
    D Van der Merwe
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
    J S Afr Vet Assoc 77:197-201. 2006
    ..cymosum and other species from the same habitat with macroscopic features that resemble those of D. cymosum, including Euclea crispa, Combretum zeyheri, Burkea afrikana and Lannea discolor.
  77. ncbi Antibacterial and antifungal activities of extracts of combretum molle
    Kaleab Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 44:269-77. 2006
    In traditional medical practices of Ethiopia the aqueous extracts obtained from the stem bark of Combretum molle (R. Br. Ex. G. Don...
  78. doi Hypoglycaemic effect of mollic acid glucoside, a 1alpha-hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf, in rodents
    John A O Ojewole
    Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu Natal, Durban 4000, South Africa
    J Nat Med 63:117-23. 2009
    ..and antidiabetic properties of mollic acid glucoside (MAG), a 1alpha-hydroxycycloartenoid extractive from Combretum molle leaf, in rodents. Stepwise, escalated doses of MAG (5-80 mg/kg p.o...
  79. pmc Ethnopharmacological survey of six medicinal plants from Mali, West-Africa
    Tom Erik Grønhaug
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068 Blindern, 0316 Oslo, Norway
    J Ethnobiol Ethnomed 4:26. 2008
    ..The plants investigated were Biopyhtum petersianum, Cola cordifolia, Combretum molle, Opilia celtidifolia, Parkia biglobosa and Ximenia americana...
  80. doi Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation
    Adama Gansane
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso
    Parasitol Res 106:335-40. 2010
    ..of trunk for Zanthoxylum zanthoxyloides and leaves for Sarcocephalus latifolius instead of roots, and leaves for Combretum molle and Anogeissus leiocarpus instead of stem bark...
  81. ncbi Combretastatin A4 phosphate: background and current clinical status
    Scott L Young
    OXiGENE, Inc, 230 Third Avenue, Waltham, MA 02451, USA
    Expert Opin Investig Drugs 13:1171-82. 2004
    ..CA4P is a water-soluble prodrug of the cis-stilbene CA4 originally isolated from the tree Combretum caffrum...
  82. doi [Traditional medicine in kidney diseases in Burkina Faso]
    Adama Lengani
    Service de Nephrologie et Hemodialyse, CHU Yalgado Ouedraogo, Ouagadougou 01, Burkina Faso
    Nephrol Ther 6:35-9. 2010
    ..We identify 61 medicinal plants related to 30 families and 51 genders. Combretum micranthum, Chrysantellum americanum and Tamarindus indica were the most frequent species plants under use...
  83. doi Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus
    Sheila Maregesi
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 76:195-201. 2010
    ..25 microg/mL), Combretum adenogonium (leaves), Euphorbia tirucalli (root), Harrisonia abyssinica (root), Rhynchosia sublobata (root), ..
  84. doi An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana
    Christian Agyare
    Department of Pharmaceutics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    J Ethnopharmacol 125:393-403. 2009
    ..In vitro screening of selected extracts from these plants on cell physiology of human dermal fibroblasts and keratinocytes was to be performed...
  85. pmc Complexity in water and carbon dioxide fluxes following rain pulses in an African savanna
    Christopher Alan Williams
    Graduate School of Geography, Clark University, 950 Main Street, Worcester, MA 01610, USA
    Oecologia 161:469-80. 2009
    ..ET), and net ecosystem CO2 exchange measured for 5 years at an eddy covariance tower sited in an Acacia-Combretum savanna near Skukuza in the Kruger National Park, South Africa...
  86. ncbi Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity
    Adriána Kovács
    Department of Pharmacognosy, University of Szeged, Eotvos u 6, H 6720 Szeged, Hungary
    Phytochemistry 68:687-91. 2007
    ..52+/-0.70 and 3.64+/-0.12 microM, respectively...
  87. ncbi Antioxidant and antibacterial activities of Combretum nioroense Aubrév. ex Keay (Combretaceae)
    T H Coulidiati
    Laboratoire de Biochimie et Chimie Appliquées, UFR SVT, Universite de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso
    Pak J Biol Sci 12:264-9. 2009
    ..activities of acetone extract, ethyl acetate, n-butanol and n-hexane fractions of acetone extract from leaves of Combretum nioroense Aubrév. ex Keay were investigated...
  88. doi Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P
    Anupama Shirali
    Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, USA
    J Nat Prod 72:414-21. 2009
    ..CA1 is a natural product isolated from the African bush willow tree (Combretum caffrum) that has important medicinal value due, in part, to its ability to inhibit tubulin assembly...
  89. doi In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae
    I O Ademola
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
    Vet Parasitol 169:198-203. 2010
    ..The anthelmintic effect of acetone leaf extract and fractions of Combretum molle was investigated to determine the relative efficacy of the components against gastrointestinal sheep ..
  90. ncbi Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents
    Maojiang Wu
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China
    Bioorg Med Chem Lett 17:869-73. 2007
    ..A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity...
  91. ncbi Antiulcerogenic activity of Combretum leprosum
    P H M Nunes
    Departamento de Biofísica e Fisiologia CCS, Universidade Federal do Piaui, Campus Universitário Ministro Petrônio Portela Bloco SG 8, Ininga, 64049 550, Teresina PI, Brazil
    Pharmazie 64:58-62. 2009
    This study investigates the effects of an ethanolic extract from the stem bark of Combretum leprosum Mart...
  92. ncbi Combretastatin A-4 analogues as antimitotic antitumor agents
    Nguyen Hai Nam
    Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, RI 02881, USA
    Curr Med Chem 10:1697-722. 2003
    ..Among these, combretastatin A-4 (CA-4), isolated from a South African tree Combretum caffrum, is one of the most potent antimitotic agents...
  93. ncbi Combretastatins: from natural products to drug discovery
    Alessandra Cirla
    School of Chemistry, Queen s University Belfast, Belfast BT9 5AG, Northern Ireland
    Nat Prod Rep 20:558-64. 2003
    The combretastatins are a group of anti-mitotic agents isolated from the bark of the South African tree Combretum caffrum...
  94. doi Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction
    Marc Litaudon
    Institut de Chimie des Substances Naturelles, UPR2301, CNRS, 91198 Gif sur Yvette, France
    J Nat Prod 72:1314-20. 2009
    ..The ethyl acetate extracts obtained from the leaves and flowers of Combretum sundaicum and the leaves of Lantana camara were selected for their interaction with the Bcl-xL/Bak association...
  95. ncbi Antimicrobial and anti-inflammatory activity of four known and one new triterpenoid from Combretum imberbe (Combretaceae)
    J E Angeh
    Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, Pretoria, South Africa
    J Ethnopharmacol 110:56-60. 2007
    b>Combretum imberbe is used widely in Africa inter alia for treating bacterial infections...
  96. ncbi Antimalarial activity of Sida acuta Burm. f. (Malvaceae) and Pterocarpus erinaceus Poir. (Fabaceae)
    Damintoti Karou
    Universite de Ouagadougou, Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Laboratoire de Biochimie, 03 BP 7131 Ouagadougou 03, Burkina Faso
    J Ethnopharmacol 89:291-4. 2003
    ..Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro on fresh clinical ..