Summary: A plant genus of the family CELASTRACEAE. The leafy stems of khat are chewed by some individuals for stimulating effect. Members contain ((+)-norpseudoephedrine), cathionine, cathedulin, cathinine & cathidine.
Publications145 found, 100 shown here
- The effect of chewing Khat leaves on human moodNageeb A Hassan
Departments of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, University of Sana a, PO Box 14315 MAAIN, Sana a, Republic of Yemen
Saudi Med J 23:850-3. 2002Chewing fresh leaves of the Khat plant (Catha edulis), represents a widespread habit with a deep-rooted sociocultural tradition in Yemen...
- Khat: pharmacological and medical aspects and its social use in YemenAhmed Al-Motarreb
Department of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff CF10 3XF, UK
Phytother Res 16:403-13. 2002Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen...
- Khat habit and its health effect. A natural amphetamineIshraq Dhaifalah
Department of Gynecology and Obstetric, Al Thawra University Hospital, Sana a, Yemen Republic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 148:11-5. 2004..In recent years, several cases of intoxication have been observed outside the area of its use. In this view, the khat habit, its health effects and socioeconomic aspects are described with the political issue they imply...
- Khat (Catha edulis): health aspects of khat chewingN A G M Hassan
Department of Clinical Pharmacology and Therapeutics, Al Thawra Teaching Hospital, Faculty of Medicine and Health Sciences, University of Sana a, Sana a, Yemen
East Mediterr Health J 13:706-18. 2007b>Catha edulis Forsk leaves (khat) are chewed daily by a high proportion of the adult population in Yemen for the mild stimulant effect...
- Toxicological evaluation of Catha edulis leaves: a long term feeding experiment in animalsMolham Al-Habori
Clinical Biochemistry Department, University of Sana a, PO Box 19065, Sana a, Yemen
J Ethnopharmacol 83:209-17. 2002In this study the long term (6 months) toxicological effect of varying levels of Catha edulis leaves were examined on the plasma concentration of liver enzymes as well as the histopathology of tissue sections of the liver...
- Prevalence of cigarette smoking and khat chewing among Aden university medical students and their relationship to BP and body mass indexAl Khader N Laswar
Director General of Health Affairs, Aden, Associate Professor of Surgery, Aden, Yemen
Saudi J Kidney Dis Transpl 20:862-6. 2009..There was a weak positive correlation between BMI with SBP, MBP and frequency of Khat chewing...
- Substance use and its predictors among undergraduate medical students of Addis Ababa University in EthiopiaWakgari Deressa
Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Addis Ababa University, Ethiopia
BMC Public Health 11:660. 2011..This study was conducted to determine the prevalence of substance use and identify factors that influenced the behavior among undergraduate medical students of Addis Ababa University in Ethiopia...
- Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell linesTherese Bredholt
The Gade Institute, University of Bergen, Bergen, Norway
Mol Cancer 8:101. 2009An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro...
- The consumption of khat and other drugs in Somali combatants: a cross-sectional studyMichael Odenwald
PLoS Med 4:e341. 2007....
- Khat alters the phenotype of in vitro-reconstructed human oral mucosaO M Lukandu
Section for Pathology, The Gade Institute, University of Bergen, Norway
J Dent Res 89:270-5. 2010....
- Khat chewing amongst UK resident male Yemeni adults: an exploratory studySaba Kassim
Institute of Dentistry, Queen Mary s School of Medicine and Dentistry, Queen Mary, University of London, UK
Int Dent J 56:97-101. 2006..This cross sectional study recruited adult male Yemeni residents in Sheffield and Birmingham, UK, to assess their use of khat...
- Investigation into the toxicological effects of Catha edulis leaves: a short term study in animalsM Al-Mamary
Food Science Department and Animal Production Department, Faculty of Agriculture, University of Sana a, Sana a, Yemen
Phytother Res 16:127-32. 2002In this study the short term (3 months) toxicological effects of varying levels of Catha edulis leaves were examined on the plasma concentration of liver enzymes and the histopathology of tissue sections of various organs including the ..
- Khat use and neurobehavioral functions: suggestions for future studiesRichard Hoffman
Department of Behavioral Sciences, University of Minnesota Medical School Duluth, 1035 University Avenue, Duluth, MN 55812 3031, USA
J Ethnopharmacol 132:554-63. 2010....
- The stimulant khat--another door in the wall? A call for overcoming the barriersMichael Odenwald
University of Konstanz, Germany
J Ethnopharmacol 132:615-9. 2010..In this article, we comment on the current international discourse on khat, we highlight pitfalls and and suggest balanced national international regulatory actions...
- Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future researchA Al-Motarreb
Cardiac Centre, Internal Medicine Department, Sana a University, Sana a, Yemen
J Ethnopharmacol 132:540-8. 2010The leaves of khat (Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their cathinone content...
- The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretionCharles D R Murray
Royal Free Hospital, London, United Kingdom
Appetite 51:747-50. 2008The leaves of the khat plant (Catha edulis) are chewed for their pleasurable effects. Chewing releases cathinone which may decrease appetite through an unknown mechanism...
- Khat a drug of abuse: roles of free radicals and antioxidantsSamir L Aleryani
Vanderbilt University, The Vanderbilt Clinic, Nashville, TN 37232 5310, USA
Drug Test Anal 3:548-51. 2011....
- Khat use and mental illness: a critical reviewNasir Warfa
Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, UK
Soc Sci Med 65:309-18. 2007..There is a need for improved research on khat use and its possible association with psychiatric disorders...
- Khat chewing and arterial blood pressure. A randomized controlled clinical trial of alpha-1 and selective beta-1 adrenoceptor blockadeNageeb A Hassan
Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, University of Sana a, PO Box 14315 MAAIN, Yemen
Saudi Med J 26:537-41. 2005..The aim of this work was to study prospectively the effect of alpha-1 and selective beta-1 adrenoceptor blockade on cardiovascular effects of khat chewing in healthy volunteers...
- Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in ratsMehret Yerdaw Banjaw
Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Germany
Behav Brain Res 160:365-73. 2005..inhibition deficit were induced under the same context by intermittent oral administration of S-(-)-cathinone or Catha edulis extract in rats...
- Subchronic administration of Catha edulis F. (khat) extract is marked by elevation of cardiac biomarkers and subendocardial necrosis besides blood pressure alteration in ratsEndalkachew Admassie
Department of Pharmacology, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia
J Ethnopharmacol 136:246-53. 2011..This study attempted to evaluate cardiovascular substrates that predispose individuals to these episodes by using both biochemical and morphologic-pathologic studies...
- Experimental gingivitis in male khat (Catha edulis) chewersNezar Noor Al-Hebshi
University of Science and Technology, Faculty of Medical Sciences Dentistry, Sana a, Yemen
J Int Acad Periodontol 12:56-62. 2010..Whether or not khat chewing is detrimental to the periodontium remains uncertain. Findings from cross-sectional studies have been contradictory and, in most cases, uncontrolled for confounders...
- The health impacts of khat: a qualitative study among Somali-AustraliansHeather Douglas
TC Beirne School of Law, University of Queensland, Brisbane, QLD
Med J Aust 195:666-9. 2011..To identify patterns of khat use among Somali-Australians in Australia and to explore their views about the links between khat use and personal health...
- Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblastsOchiba M Lukandu
Institute of Oral Sciences, Oral Pathology and Forensic Odontology, University of Bergen, and Centre for International Health, University of Bergen, Bergen, Norway
Eur J Oral Sci 116:23-30. 2008..The results show that stress induced by khat modulates the cell cycle in oral keratinocytes and fibroblasts. It is further speculated whether khat could have similar effects in vivo, especially in keratinocytes...
- Constipating and spasmolytic effects of Khat (Catha edulis Forsk) in experimental animalsE Makonnen
Department of Pharmacology, Faculty of Medicine, Addis Ababa University
Phytomedicine 7:309-12. 2000The constipating and spasmolytic effects of Catha edulis Forsk (Khat) were investigated in whole mice and on isolated guinea pig ileum. D-amphetamine was employed in both experiments for comparison...
- Oral manifestations of habitual khat chewing: a case-control studyNoam Yarom
Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e60-6. 2010Khat, or qat (Catha edulis), is a shrub indigenous to Yemen and certain parts of eastern Africa...
- Free radicals are present in human serum of Catha edulis Forsk (Khat) abusersAhmed A Al-Akwa
Department of Clinical Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana a University, Yemen
J Ethnopharmacol 125:471-3. 2009Khat (Catha edulis Forsk) is a naturally occurring drug with an amphetamine-like structure and action. It has been postulated that amphetamine induces free radical formation...
- Prevalence and determinants of khat (Catha edulis) chewing among high school students in eastern Ethiopia: a cross-sectional studyAyalu A Reda
Department of Public Health, College of Health Sciences, Haramaya University, Harar, Ethiopia
PLoS ONE 7:e33946. 2012Use of psychoactive drugs such as khat leaves (Catha edulis) alter moods and emotional state and lead to adverse effects on the health and social life of users...
- Khat (Catha edulis) alters the phenotype and anti-microbial activity of peripheral blood mononuclear cellsCraig Murdoch
Academic Unit of Oral and Maxillofacial Medicine and Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
J Ethnopharmacol 138:780-7. 2011..This study examined the biological effects of khat on the phenotype and function of peripheral blood mononuclear cells (PBMCs)...
- Determinants of CD4 counts among HIV-negative Ethiopians: role of body mass index, gender, cigarette smoking, khat (Catha Edulis) chewing, and possibly altitude?C Abuye
Department of Nutrition, Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
J Clin Immunol 25:127-33. 2005..Low body mass index among Ethiopians may have contributed to their overall low CD4 counts. Other factors remain to be elucidated...
- Khat (Catha edulis)-an updated reviewNezar N Al-Hebshi
Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Addict Biol 10:299-307. 2005The habit of chewing fresh leaves and twigs of khat (Catha edulis) for their stimulating amphetamine-like effects is highly prevalent in East Africa and southwest on the Arabic peninsula...
- Khat in the Horn of Africa: historical perspectives and current trendsEzekiel Gebissa
Kettering University, Liberal Studies, 1700 University Ave, Flint, MI 48504, USA
J Ethnopharmacol 132:607-14. 2010..This article looks at the history of the expansion of khat consumption from the traditional chew regions to Western countries and assesses the implication of possible international control for its use and trade in the Horn of Africa...
- Khat and alcohol use and risky sex behaviour among in-school and out-of-school youth in EthiopiaDerege Kebede
Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
BMC Public Health 5:109. 2005..This study was conducted to describe the magnitude of risky sexual behaviour (unprotected sex and early initiation of sexual activity) and its association with Khat and alcohol consumption in Ethiopian youths...
- Khat - a controversial plantErica E Balint
Department of Human Anatomy, Faculty of Medicine, University of Szeged, Szeged, Hungary
Wien Klin Wochenschr 121:604-14. 2009Khat (Catha edulis) is a shrub or tree whose leaves have been chewed for centuries by people who live in the Eastern part of Africa and the Arabian Peninsula...
- Is miraa a drug?: categorizing Kenyan khatNeil Carrier
Wellcome Unit for the History of Medicine, Oxford, UK
Subst Use Misuse 43:803-18. 2008..War-on-drugs rhetoric is countered by those more enamored of the substance by discourse in which its use is labeled "traditional," "cool," and an "economic miracle."..
- Cigarette smoking and khat chewing among university instructors in EthiopiaY Kebede
Gondar College of Medical Sciences, P O Box 196, Gondar, Ethiopia
East Afr Med J 79:274-8. 2002..To assess the prevalence and risk factors of cigarette smoking and khat chewing...
- Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in ratsMehret Yerdaw Banjaw
Department of Neuropharmacology, Zoological Institute, University of Tübingen Auf der Morgenstelle 28E, 72076 Tubingen, Germany
Behav Brain Res 156:181-9. 2005..A study was conducted to evaluate the effect of repeated oral administration of Catha edulis in rats. Male Sprague-Dawley rats divided into five groups received: saline, S-(-)-cathinone (1...
- Histopathologic changes in oral mucosa of Yemenis addicted to water-pipe and cigarette smoking in addition to takhzeen al-qatAiman A Ali
Department of Biomedical Dental Sciences Unit of Oral Pathology and Medicine, King Faisal University College of Dentistry, Dammam, Saudi Arabia
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e55-9. 2007..Because the clinicopathologic effects of takhzeen al-qat are similar to those induced by smoking, the aim of this paper was to study the oral effect of 3 bad oral habits: takhzeen al-qat and cigarette and water-pipe smoking...
- Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leavesStefan W Toennes
Institute of Forensic Toxicology, Centre of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
Br J Clin Pharmacol 56:125-30. 2003..The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine...
- Cathinone preservation in khat evidence via dryingJohn S Chappell
Drug Enforcement Administration, Western Laboratory, San Francisco, CA 94105, USA
Forensic Sci Int 195:108-20. 2010A primary concern with the forensic analysis of the khat plant (Catha edulis) has been the need to preserve the principle psychoactive component, cathinone, which converts to the less-active substance, cathine, after harvesting...
- Intoxication with Qăat, Catha edulis LRobert Michael Bruce-Chwatt
J Forensic Leg Med 17:232-5. 2010The increasing use of Qăat, Catha edulis L. in immigrants from the Horn of Africa to the UK is a matter of concern and may yet become a problem in the UK diaspora...
- Developmental patterns of phenylpropylamino alkaloids accumulation in khat (Catha edulis, Forsk.)Raz Krizevski
Department of Aromatic, Medicinal and Spice Crops, Newe Ya ar Research Center, Agricultural Research Organization, PO Box 1021, Ramat Yishay 30095, Israel
J Ethnopharmacol 114:432-8. 2007Khat (Catha edulis Forsk., Celastraceae) is a perennial shrub that was introduced to Israel by Yemenite immigrants. Khat young leaves are chewed as a stimulant...
- Effect of Catha edulis on plasma glucose and C-peptide in both type 2 diabetics and non-diabeticsR Saif-Ali
Clinical Biochemistry Department, Faculty of Medicine and Health Sciences, University of Sana a, P O Box 19065, Sana a, Yemen
J Ethnopharmacol 86:45-9. 2003....
- A review of the neuropharmacological properties of khatAnteneh M Feyissa
Department of Pharmacology and Therapeutics, NUI Galway, Galway, Ireland
Prog Neuropsychopharmacol Biol Psychiatry 32:1147-66. 2008The psychostimulant khat (Catha edulis Forsk), is a herbal drug cultivated and chewed as a recreational and socializing drug in East Africa and the Arabian Peninsula for centuries...
- The potential adverse effects of habitual use of Catha edulis (khat)Molham Al-Habori
Department of Clinical Biochemistry, Faculty of Medicine and Health Sciences, University of Sana a, P O Box 19065, Sana a, Republic of Yemen
Expert Opin Drug Saf 4:1145-54. 2005The habit of Catha edulis Forsk (khat) chewing has prevailed for centuries among populations in the horn of Africa and the Arabian peninsula. Fresh leaves of Catha edulis are customarily chewed to attain a state of stimulation...
- Risk assessment of khat use in the Netherlands: a review based on adverse health effects, prevalence, criminal involvement and public orderE J M Pennings
Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Regul Toxicol Pharmacol 52:199-207. 2008..A similar conclusion may be drawn for countries with a comparable prevalence of khat use and khat related public order disturbance...
- Khat special edition introductionSusan Beckerleg
School of Health and Social Studies, University of Warwick, Coventry, UK
Subst Use Misuse 43:749-61. 2008Although khat (Catha edulis) is not widely known outside its countries of production in East Africa and Yemen, it evokes strong views among consumers, development workers, and government officials who often behave as self-styled experts ..
- Exploration of adverse psychological symptoms in Yemeni khat users by the Symptoms Checklist-90 (SCL-90)Nabil Numan
National Institute of Psychiatry and Neurology, Semmelweis University, Budapest, Hungary
Addiction 99:61-5. 2004..The present study was aimed at assessing associations between psychological symptoms and khat use in the Yemeni population...
- Driving under the influence of khat--alkaloid concentrations and observations in forensic casesStefan W Toennes
Institute of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt, Kennedyallee 104, Frankfurt Main D 60596, Germany
Forensic Sci Int 140:85-90. 2004The use of the herbal stimulant khat (Catha edulis FORSK) is maintained by immigrants from countries where it is part of their cultural life (Arabian Peninsula and eastern Africa)...
- Effect of khat, its constituents and restraint stress on free radical metabolism of ratsTariq M Al-Qirim
Department of Biochemistry, F o Life Sciences, A M U, 202002 Aligarh, India
J Ethnopharmacol 83:245-50. 2002The leaves of khat (Catha edulis) are found to have stimulating and pleasurable effect and are chewed habitually by people of East Africa and Arabian Peninsula...
- Khat (Catha edulis) consumption causes genotoxic effects in humansF Kassie
Institute of Cancer Research, Vienna, Austria
Int J Cancer 92:329-32. 2001....
- Khat (Catha edulis) chewing during pregnancy in Yemen: findings from a national population surveyMarwan Khawaja
Center for Research on Population and Health, Faculty of Health Sciences, American University of Beirut, Bliss Street, P O Box 11 0236, Beirut, Lebanon
Matern Child Health J 12:308-12. 2008..This study examines the prevalence of khat chewing among women during pregnancy and some of the risk factors for this habit in Yemen...
- Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cellsOchiba M Lukandu
Section of Pathology, The Gade Institute, Faculty of Medicine and Odontology, University of Bergen, Norway
Toxicology 263:108-16. 2009..This study describes a novel mechanism of khat-induced cell death in primary normal oral keratinocytes and fibroblasts involving an early pivotal effect on mitochondrial function and integrity...
- Use and perception of the psychostimulant, khat (catha edulis) among three occupational groups in south western UgandaA O Ihunwo
Department of Anatomy, Histology and Embryology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
East Afr Med J 81:468-73. 2004To examine the use of and perception of the psychostimulant, khat (catha edulis) in three towns in south-western Uganda.
- Khat chewing and acute myocardial infarctionA Al-Motarreb
Heart 87:279-80. 2002
- Catha edulis (Khat) induces cell death by apoptosis in leukemia cell linesE Dimba
Department of Odontology Oral Pathology and Forensic Odontology, Faculty of Dentistry, University of Bergen, Bergen, Norway
Ann N Y Acad Sci 1010:384-8. 2003....
- Khat chewing is a risk factor for acute myocardial infarction: a case-control studyA Al-Motarreb
Al Thawrah Teaching Hospital, Sana a, Yemen
Br J Clin Pharmacol 59:574-81. 2005..The aim was to examine the hypothesis that khat chewing is a risk factor for acute myocardial infarction (AMI) using a hospital-based matched case-control study...
- Association of smoking and khat (Catha edulis Forsk) use with high blood pressure among adults in Addis Ababa, Ethiopia, 2006Fikru Tesfaye
School of Public Health, Addis Ababa University, PO Box 11490, Addis Ababa, Ethiopia
Prev Chronic Dis 5:A89. 2008..We assessed the prevalence of substance use and its association with high blood pressure among adults in Addis Ababa, Ethiopia...
- Khat induced hemorrhoidal disease in YemenA M Al-Hadrani
Department of Surgery, Faculty of Medicine, Sana a University, Sana a, Republic of Yemen
Saudi Med J 21:475-7. 2000..The aim of this study was to evaluate the potential association between the habit of khat chewing and the development of hemorrhoidal disease..
- Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in SomaliaMichael Odenwald
Department of Psychology, University of Konstanz, Fach D25, D 78476 Konstanz, Germany
BMC Med 3:5. 2005..We aimed to explore the prevalence of psychotic disorders among the general population and the association between khat use and psychotic symptoms...
- Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cellsE A O Dimba
Department of Odontology Oral Pathology and Forensic Odontology, Faculty of Dentistry and Centre for International Health, University of Bergen, Bergen, Norway
Br J Cancer 91:1726-34. 2004..It is concluded that khat induces a rather swift and sensitive cell death by apoptosis through mechanisms involving activation of caspase-1, -3 and -8...
- Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblastsOchiba M Lukandu
Section for Pathology, The Gade Institute, Haukeland University Hospital, University of Bergen, Bergen, Norway
Toxicol Sci 103:311-24. 2008..In summary, khat induced apoptotic cell death in primary normal oral keratinocytes and fibroblasts by an early effect on mechanisms that regulate oxidative stress...
- A study of 342 oral keratotic white lesions induced by qat chewing among 2500 YemeniAiman A Ali
Department of Oral Pathology and Medicine, Faculty of Dentistry, University of Sana a, Yemen
J Oral Pathol Med 33:368-72. 2004..Various studies demonstrated clear effects of this habit on the systemic organs of the human body. The lack of studies, however, on the effects of this habit on oral mucosa was the major motive of this study...
- Histopathological changes in oral mucosa due to takhzeen al-qat: a study of 70 biopsiesAiman A Ali
Department of Oral Pathology and Medicine, Faculty of Dentistry, University of Sana a, Yemen
J Oral Pathol Med 35:81-5. 2006..At the oral mucosa, it causes clinical changes that appear as white lesions. The aim of this paper was to study the histopathological changes in the oral mucosa related to takhzeen al-qat...
- Meet the khat-headsT Trent Gegax
Newsweek 140:35. 2002
- Effect of khat chewing on 14 selected periodontal bacteria in sub- and supragingival plaque of a young male populationN N Al-Hebshi
Department of Odontology Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Oral Microbiol Immunol 20:141-6. 2005The habit of chewing khat (Catha edulis) for its amphetamine-like effects is highly prevalent in Yemen and east Africa, and has expanded to Western countries...
- Khat (Catha edulis Forsk) chewing, sociodemographic description and its effect on academic performance, Jimma University students 2002Andualem Mossie Ayana
Jimma University, Faculty of Medical Sciences, P O Box 378, Jimma, Ethiopia
Ethiop Med J 42:125-36. 2004Khat (Catha edulis Forsk) chewing habit is being a hot issue of discussion nation wide...
- Effect of Catha edulis (khat) on behaviour and its potential to induce seizures in Sprague Dawley ratsE Oyungu
Department of Medical Physiology, Moi University, P O Box 4606, Eldoret, Kenya
East Afr Med J 84:219-25. 2007....
- [Evaluation of compliance with antiretroviral treatment in a cohort of 200 patients in Djibouti, 2005]A A Ahmed
Ministere de la Sante, Djibouti
East Mediterr Health J 13:1286-97. 2007..In multivariate analysis, community support and level of education protected against non-compliance. Patients having already missed a dose and those dissatisfied with confidentiality had a 4 times greater risk of non-compliance...
- The perioperative implications of khat useO A Bamgbade
Eur J Anaesthesiol 25:170-2. 2008
- Effects of khat (Catha edulis) consumption on reproductive functions: a reviewJ M Mwenda
Institute of Primate Research, P O Box 24481, Karen, Nairobi, Kenya
East Afr Med J 80:318-23. 2003To review research findings on the effects of khat (Catha edulis) chewing on reproductive functions.
- [Khat-induced psychosis?]G Degraeve
Tijdschr Psychiatr 49:763-7. 2007..Two cases of suspected khat-induced psychosis are presented. Treatment of choice appears to be discontinuation of khat use, possibly combined with treatment with an antipsychotic...
- Anger expression, negative life events and violent behaviour among male college students in EthiopiaBizu Gelaye
Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington 98195, USA
Scand J Public Health 36:538-45. 2008..To assess the prevalence of violent behaviour and to identify risk factors associated with violent behaviour among male college students in Ethiopia...
- [Khat--a new drug of abuse in Norway]Muhammad Al-Samarraie
Divisjon for rettstoksikologi og rusmiddelforskning Nasjonalt folkehelseinstitutt Postboks 4404 Nydalen 0403 Oslo
Tidsskr Nor Laegeforen 127:574-6. 2007..The stimulating drug, Khat, is a drug of abuse that has become known in Norway due to increased immigration from East-Africa, especially Somalia...
- Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated ratsM Y Banjaw
Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Tuebingen, Germany
J Neural Transm 113:543-56. 2006The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm...
- Khat chewing: an emerging drug concern in Australia?Johana Stefan
Aust N Z J Psychiatry 39:842-3. 2005
- In vitro effects of crude khat extracts on the growth, colonization, and glucosyltransferases of Streptococcus mutansNezar Noor Al-Hebshi
Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Acta Odontol Scand 63:136-42. 2005..It is shown that khat leaves contain water-soluble constituents that inhibit some cariogenic properties of S. mutans in vitro...
- Coronary and aortic vasoconstriction by cathinone, the active constituent of khatA L Al-Motarreb
Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cathays Park, Cardiff CF10 3XF, UK
Auton Autacoid Pharmacol 23:319-26. 2003..The precise mechanism for this vasoconstriction remains to be determined. The coronary vasoconstriction may explain the increased incidence of myocardial infarction in khat chewers, which may arise from coronary vasospasm...
- Catha edulis: a new differential in the diagnosis of pregnancy induced hypertensionK M Kuczkowski
J Gynecol Obstet Biol Reprod (Paris) 33:535. 2004
- Common drugs of abuse--Part IIMary Linda Stotter Cuddy
J Pract Nurs 54:5-8, 25-31; quiz 17-9. 2004..Drug abuse affects a significant number of individuals of all ages. Health care practitioners must be knowledgeable about both the physiological effects of such drugs and the impact of drug-seeking behavior on their patients...
- Use of doubly protonated molecules in the analysis of cathedulins in crude extracts of khat (Catha edulis) by liquid chromatography/serial mass spectrometryGeoffrey C Kite
Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK
Rapid Commun Mass Spectrom 17:1553-64. 2003Analysis of crude methanolic extracts of fresh khat (Catha edulis) by liquid chromatography/mass spectrometry (LC/MS) revealed the presence of 62 cathedulin alkaloids (compared with 15 published structures)...
- Determination of cathinone, cathine and norephedrine in hair of Yemenite khat chewersFrank Sporkert
Institute of Legal Medicine, University Rostock, St Georg Street 108, 18055 Rostock, Germany
Forensic Sci Int 133:39-46. 2003..7ng/mg for CTN. A highly significant correlation was found between the self-reported data about the khat consumption habits of the volunteers (4-56h chewing per week) and the concentrations of norephedrine and norpseudoephedrine in hair...
- [The house of shame and the boys in Akerselva]Willy Pedersen
Tidsskr Nor Laegeforen 127:563. 2007
- Qat chewing and pesticides: a study of adverse health effects in people of the mountainous areas of YemenJunko Date
Graduate School of Medicine, Yamaguchi University, Japan
Int J Environ Health Res 14:405-14. 2004..It is concluded that chewing qat grown with chemical pesticides causes considerable adverse health effects in human beings...
- In vitro antimicrobial and resistance-modifying activities of aqueous crude khat extracts against oral microorganismsNezar Al-hebshi
Laboratory of Oral Microbiology, Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
Arch Oral Biol 51:183-8. 2006To assess antimicrobial activities of aqueous crude khat (Catha edulis) extracts against a panel of oral microorganisms and to test their ability to modify bacterial resistance to tetracycline and penicillin in vitro.
- Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboonJason M Mwenda
Institute of Primate Research, P O Box 24481, Karen, Nairobi, Kenya
J Ethnopharmacol 103:379-84. 2006The potential effect of Khat (Catha edulis, Celastraceae) on fertility in humans has not been elucidated...
- Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbitsA W Nyongesa
Department of Veterinary Anatomy and Physiology, University of Nairobi, P O Box 30197, Nairobi, Kenya
J Ethnopharmacol 116:245-50. 2008..This study investigated the effects of fresh khat extract on specific circulating hormones in male rabbits...
- Antifungal efficacy of ten selected South African plant species against Cryptococcus neoformansT A Mokoka
Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort, South Africa
Pharm Biol 48:397-404. 2010..Harv. (Rutaceae), Morusmesozygia Stapf (Moraceae), Calodendrum capense (L.f.) Thunb. (Rutaceae), Catha transvaalensis Codd (Celastraceae), Cussonia zuluensis Strey (Araliaceae), Ochna natalitia (Meisn.) Walp...
- Plants and the central nervous systemE A Carlini
Department of Psychobiology, Paulista School of Medicine, Federal University of Sao Paulo, Rua Botucatu, 862 Ed Ciências Biomédicas, 1o andar, CEP 04023 062, Sao Paulo, SP, Brazil
Pharmacol Biochem Behav 75:501-12. 2003..Ma Huang), Paullinia spp. (guaraná), Catha edulis Forssk. (khat)] and plants used to improve general health conditions (plant adaptogens) were scrutinized...
- Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionizationJochen Beyer
Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
J Mass Spectrom 42:150-60. 2007The herbal stimulants Ephedra species, Catha edulis (khat), and Lophophora williamsii (peyote) have been abused for a long time. In recent years, the herbal drug market has grown owing to publicity on the Internet...
- Prevalence of Helicobacter pylori infection among patients with dyspepsia in South-Western Saudi ArabiaAyobanji E Ayoola
Division of Gastroenterology, King Fahd Central Hospital, Gizan, Kingdom of Saudi Arabia
Saudi Med J 25:1433-8. 2004..Helicobacter pylori (H. pylori) infection is a major cause of various upper gastrointestinal (UGI) disorders. The aim of this study was to determine the prevalence of H. pylori among patients with dyspepsia...
- Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent mannerS A Adeoya-Osiguwa
Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King s College London, London, UK
Hum Reprod 22:756-65. 2007..Cathine, an amphetamine-related metabolite of a compound found in Catha edulis leaves, accelerates capacitation and inhibits spontaneous acrosome loss by regulating cAMP production...
- Knowledge and perception of pulmonary tuberculosis in pastoral communities in the middle and Lower Awash Valley of Afar region, EthiopiaMengistu Legesse
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
BMC Public Health 10:187. 2010..In this study, we assessed the knowledge and perception of apparently healthy individuals about pulmonary tuberculosis (PTB) in pastoral communities of Afar...
- Regulation of phagocytosis in macrophages by neuraminidase 1Volkan Seyrantepe
Sainte Justine University Hospital Centre, University of Montreal, Montreal, QuebecH3T 1C5, Canada
J Biol Chem 285:206-15. 2010..and dendritic cells is accompanied by induction of cell-surface neuraminidase 1 (Neu1) and cathepsin A (CathA), the latter forming a complex with and activating Neu1...
- Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformationTatsusada Yoshida
Institute of Health Biosciences, The University of Tokushima Graduate School, 1 78 Shomachi, Tokushima 770 8505, Japan
Biochim Biophys Acta 1794:1693-9. 2009Human lysosomal protective protein/cathepsin A (CathA) is a multifunctional protein that exhibits not only protective functions as to lysosomal glycosidases, i.e...
- A pilot study on the effect of catha edulis frosk., (celastraceae) on metabolic syndrome in wokw ratsSamira Abdulla Mahmood
Department of Pharmacology, Faculty of Medicine and Health Sciences, Aden University, Aden, Yemen
Afr J Tradit Complement Altern Med 5:271-7. 2008This study investigated the effect of Catha edulis (khat) on some important parameters of the metabolic syndrome in Wistar Ottawa Karlsburg W (WOKW ) rat...
- Serine carboxypeptidases in regulation of vasoconstriction and elastogenesisAlexey V Pshezhetsky
Department of Medical Genetics, CHU Sainte Justine Research Center, Departments of Pediatrics and Biochemistry, University of Montreal, Montreal, Quebec H3T1C5, Canada
Trends Cardiovasc Med 19:11-7. 2009..The major lysosomal serine carboxypeptidase A (cathepsin A [CathA]), also known as protective protein, activates and stabilizes two other lysosomal enzymes, beta-galactosidase and ..
- Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockadeA A Nasher
Department of Surgery, Faculty of Medicine, University of Sana a, Republic of Yemen
Br J Urol 75:597-8. 1995To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
- Introduction to the special issue: The changing use and misuse of khat (Catha edulis)-Tradition, trade and tragedyMichael Odenwald
University of Konstanz, Fachbereich Psychologie, P O BOX 5560 25, 78457 Konstanz, Germany
J Ethnopharmacol 132:537-9. 2010..This special issue of the Journal of Ethnopharmacology contains articles written by different conference speakers that present the current state of knowledge and the challenges for future research and politics...
- Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1Volkan Seyrantepe
Department of Medical Genetics, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
Circulation 117:1973-81. 2008Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against ..
- Drug use in a rural secondary school in KenyaDavid M Ndetei
Department of Psychiatry, University of Nairobi, Nairobi, Kenya
Subst Abus 31:170-3. 2010..Alcohol, tobacco, khat (catha edulis) and bhang (cannabis) were the most commonly reported substance of use, with user prevalence rates of 5...
- Khat Chewing: Its Association with HIV Status and CD4 T CellsDella Berhanu; Fiscal Year: 2009..5%. There has been recent evidence that khat (Catha edulis), a locally grown and widely used drug, is associated with sexual activity and unprotected sex...
- Trace Amine Receptor as Medication Development TargetsANITA LEWIN; Fiscal Year: 2008..Evaluation of active compounds in other neuromodulatory systems will assist in the determination of selectivity, an important consideration in medication development. [unreadable] [unreadable]..