Summary: A plant genus of the family CELASTRACEAE. The leafy stems of khat are chewed by some individuals for stimulating effect. Members contain ((+)-norpseudoephedrine), cathionine, cathedulin, cathinine & cathidine.
Publications131 found, 100 shown here
- The effect of chewing Khat leaves on human moodNageeb A Hassan
Departments of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, University of Sana a, PO Box 14315 MAAIN, Sana a, Republic of Yemen
Saudi Med J 23:850-3. 2002Chewing fresh leaves of the Khat plant (Catha edulis), represents a widespread habit with a deep-rooted sociocultural tradition in Yemen...
- Khat: pharmacological and medical aspects and its social use in YemenAhmed Al-Motarreb
Department of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff CF10 3XF, UK
Phytother Res 16:403-13. 2002Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen...
- Khat habit and its health effect. A natural amphetamineIshraq Dhaifalah
Department of Gynecology and Obstetric, Al Thawra University Hospital, Sana a, Yemen Republic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 148:11-5. 2004..In recent years, several cases of intoxication have been observed outside the area of its use. In this view, the khat habit, its health effects and socioeconomic aspects are described with the political issue they imply...
- Khat (Catha edulis): health aspects of khat chewingN A G M Hassan
Department of Clinical Pharmacology and Therapeutics, Al Thawra Teaching Hospital, Faculty of Medicine and Health Sciences, University of Sana a, Sana a, Yemen
East Mediterr Health J 13:706-18. 2007b>Catha edulis Forsk leaves (khat) are chewed daily by a high proportion of the adult population in Yemen for the mild stimulant effect...
- Khat - a controversial plantErica E Balint
Department of Human Anatomy, Faculty of Medicine, University of Szeged, Szeged, Hungary
Wien Klin Wochenschr 121:604-14. 2009Khat (Catha edulis) is a shrub or tree whose leaves have been chewed for centuries by people who live in the Eastern part of Africa and the Arabian Peninsula...
- Cathinone preservation in khat evidence via dryingJohn S Chappell
Drug Enforcement Administration, Western Laboratory, San Francisco, CA 94105, USA
Forensic Sci Int 195:108-20. 2010A primary concern with the forensic analysis of the khat plant (Catha edulis) has been the need to preserve the principle psychoactive component, cathinone, which converts to the less-active substance, cathine, after harvesting...
- Is miraa a drug?: categorizing Kenyan khatNeil Carrier
Wellcome Unit for the History of Medicine, Oxford, UK
Subst Use Misuse 43:803-18. 2008..quot; War-on-drugs rhetoric is countered by those more enamored of the substance by discourse in which its use is labeled "traditional," "cool," and an "economic miracle."..
- Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in ratsMehret Yerdaw Banjaw
Department of Neuropharmacology, Zoological Institute, University of Tübingen Auf der Morgenstelle 28E, 72076 Tubingen, Germany
Behav Brain Res 156:181-9. 2005..A study was conducted to evaluate the effect of repeated oral administration of Catha edulis in rats. Male Sprague-Dawley rats divided into five groups received: saline, S-(-)-cathinone (1...
- Khat use and neurobehavioral functions: suggestions for future studiesRichard Hoffman
Department of Behavioral Sciences, University of Minnesota Medical School Duluth, 1035 University Avenue, Duluth, MN 55812 3031, USA
J Ethnopharmacol 132:554-63. 2010....
- Intoxication with Qăat, Catha edulis LRobert Michael Bruce-Chwatt
J Forensic Leg Med 17:232-5. 2010The increasing use of Qăat, Catha edulis L. in immigrants from the Horn of Africa to the UK is a matter of concern and may yet become a problem in the UK diaspora...
- Developmental patterns of phenylpropylamino alkaloids accumulation in khat (Catha edulis, Forsk.)Raz Krizevski
Department of Aromatic, Medicinal and Spice Crops, Newe Ya ar Research Center, Agricultural Research Organization, PO Box 1021, Ramat Yishay 30095, Israel
J Ethnopharmacol 114:432-8. 2007Khat (Catha edulis Forsk., Celastraceae) is a perennial shrub that was introduced to Israel by Yemenite immigrants. Khat young leaves are chewed as a stimulant...
- A review of the neuropharmacological properties of khatAnteneh M Feyissa
Department of Pharmacology and Therapeutics, NUI Galway, Galway, Ireland
Prog Neuropsychopharmacol Biol Psychiatry 32:1147-66. 2008The psychostimulant khat (Catha edulis Forsk), is a herbal drug cultivated and chewed as a recreational and socializing drug in East Africa and the Arabian Peninsula for centuries...
- Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cellsE A O Dimba
Department of Odontology Oral Pathology and Forensic Odontology, Faculty of Dentistry and Centre for International Health, University of Bergen, Bergen, Norway
Br J Cancer 91:1726-34. 2004..It is concluded that khat induces a rather swift and sensitive cell death by apoptosis through mechanisms involving activation of caspase-1, -3 and -8...
- Association of smoking and khat (Catha edulis Forsk) use with high blood pressure among adults in Addis Ababa, Ethiopia, 2006Fikru Tesfaye
School of Public Health, Addis Ababa University, PO Box 11490, Addis Ababa, Ethiopia
Prev Chronic Dis 5:A89. 2008..We assessed the prevalence of substance use and its association with high blood pressure among adults in Addis Ababa, Ethiopia...
- Catha edulis (Khat) induces cell death by apoptosis in leukemia cell linesE Dimba
Department of Odontology Oral Pathology and Forensic Odontology, Faculty of Dentistry, University of Bergen, Bergen, Norway
Ann N Y Acad Sci 1010:384-8. 2003....
- Use and perception of the psychostimulant, khat (catha edulis) among three occupational groups in south western UgandaA O Ihunwo
Department of Anatomy, Histology and Embryology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
East Afr Med J 81:468-73. 2004OBJECTIVE: To examine the use of and perception of the psychostimulant, khat (catha edulis) in three towns in south-western Uganda. DESIGN: Cross-sectional survey. SETTINGS: Mbarara, Kabale and Fort Portal...
- Khat (Catha edulis) chewing during pregnancy in Yemen: findings from a national population surveyMarwan Khawaja
Center for Research on Population and Health, Faculty of Health Sciences, American University of Beirut, Bliss Street, P O Box 11 0236, Beirut, Lebanon
Matern Child Health J 12:308-12. 2008..This study examines the prevalence of khat chewing among women during pregnancy and some of the risk factors for this habit in Yemen...
- Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in SomaliaMichael Odenwald
Department of Psychology, University of Konstanz, Fach D25, D 78476 Konstanz, Germany
BMC Med 3:5. 2005..We aimed to explore the prevalence of psychotic disorders among the general population and the association between khat use and psychotic symptoms...
- Khat special edition introductionSusan Beckerleg
School of Health and Social Studies, University of Warwick, Coventry, UK
Subst Use Misuse 43:749-61. 2008Although khat (Catha edulis) is not widely known outside its countries of production in East Africa and Yemen, it evokes strong views among consumers, development workers, and government officials who often behave as self-styled experts ..
- Khat use and mental illness: a critical reviewNasir Warfa
Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, UK
Soc Sci Med 65:309-18. 2007..There is a need for improved research on khat use and its possible association with psychiatric disorders...
- Khat (Catha edulis Forsk) chewing, sociodemographic description and its effect on academic performance, Jimma University students 2002Andualem Mossie Ayana
Jimma University, Faculty of Medical Sciences, P O Box 378, Jimma, Ethiopia
Ethiop Med J 42:125-36. 2004Khat (Catha edulis Forsk) chewing habit is being a hot issue of discussion nation wide...
- The consumption of khat and other drugs in Somali combatants: a cross-sectional studyMichael Odenwald
PLoS Med 4:e341. 2007..We recommend that future disarmament, demobilization, and reintegration (DDR) programs need to be prepared to deal with significant drug-related problems in Somalia...
- Khat (Catha edulis)-an updated reviewNezar N Al-Hebshi
Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Addict Biol 10:299-307. 2005The habit of chewing fresh leaves and twigs of khat (Catha edulis) for their stimulating amphetamine-like effects is highly prevalent in East Africa and southwest on the Arabic peninsula...
- The potential adverse effects of habitual use of Catha edulis (khat)Molham Al-Habori
Department of Clinical Biochemistry, Faculty of Medicine and Health Sciences, University of Sana a, P O Box 19065, Sana a, Republic of Yemen
Expert Opin Drug Saf 4:1145-54. 2005The habit of Catha edulis Forsk (khat) chewing has prevailed for centuries among populations in the horn of Africa and the Arabian peninsula. Fresh leaves of Catha edulis are customarily chewed to attain a state of stimulation...
- Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblastsOchiba M Lukandu
Section for Pathology, The Gade Institute, Haukeland University Hospital, University of Bergen, Bergen, Norway
Toxicol Sci 103:311-24. 2008..In summary, khat induced apoptotic cell death in primary normal oral keratinocytes and fibroblasts by an early effect on mechanisms that regulate oxidative stress...
- Khat chewing is a risk factor for acute myocardial infarction: a case-control studyA Al-Motarreb
Al Thawrah Teaching Hospital, Sana'a, Yemen
Br J Clin Pharmacol 59:574-81. 2005..CONCLUSION: This study indicates that khat chewing is associated with AMI and is an independent dose-related risk factor for the development of myocardial infarction...
- Driving under the influence of khat--alkaloid concentrations and observations in forensic casesStefan W Toennes
Institute of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt, Kennedyallee 104, Frankfurt Main D 60596, Germany
Forensic Sci Int 140:85-90. 2004The use of the herbal stimulant khat (Catha edulis FORSK) is maintained by immigrants from countries where it is part of their cultural life (Arabian Peninsula and eastern Africa)...
- Exploration of adverse psychological symptoms in Yemeni khat users by the Symptoms Checklist-90 (SCL-90)Nabil Numan
National Institute of Psychiatry and Neurology, Semmelweis University, Budapest, Hungary
Addiction 99:61-5. 2004..CONCLUSIONS: Khat use is very common in the Yemeni population, particularly men, but it is not associated with adverse psychological symptoms...
- Risk assessment of khat use in the Netherlands: a review based on adverse health effects, prevalence, criminal involvement and public orderE J M Pennings
Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Regul Toxicol Pharmacol 52:199-207. 2008..A similar conclusion may be drawn for countries with a comparable prevalence of khat use and khat related public order disturbance...
- Effect of Catha edulis on plasma glucose and C-peptide in both type 2 diabetics and non-diabeticsR Saif-Ali
Clinical Biochemistry Department, Faculty of Medicine and Health Sciences, University of Sana'a, P.O. Box 19065, Sana'a, Yemen
J Ethnopharmacol 86:45-9. 2003....
- Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cellsOchiba M Lukandu
Section of Pathology, The Gade Institute, Faculty of Medicine and Odontology, University of Bergen, Norway
Toxicology 263:108-16. 2009..This study describes a novel mechanism of khat-induced cell death in primary normal oral keratinocytes and fibroblasts involving an early pivotal effect on mitochondrial function and integrity...
- Meet the khat-headsT Trent Gegax
Newsweek 140:35. 2002
- Khat chewing and acute myocardial infarctionA Al-Motarreb
Heart 87:279-80. 2002
- Khat (Catha edulis) consumption causes genotoxic effects in humansF Kassie
Institute of Cancer Research, Vienna, Austria
Int J Cancer 92:329-32. 2001....
- Effect of khat, its constituents and restraint stress on free radical metabolism of ratsTariq M Al-Qirim
Department of Biochemistry, F/O Life Sciences, A.M.U, 202002 Aligarh, India
J Ethnopharmacol 83:245-50. 2002The leaves of khat (Catha edulis) are found to have stimulating and pleasurable effect and are chewed habitually by people of East Africa and Arabian Peninsula...
- Khat and alcohol use and risky sex behaviour among in-school and out-of-school youth in EthiopiaDerege Kebede
Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
BMC Public Health 5:109. 2005..This study was conducted to describe the magnitude of risky sexual behaviour (unprotected sex and early initiation of sexual activity) and its association with Khat and alcohol consumption in Ethiopian youths...
- Cigarette smoking and khat chewing among university instructors in EthiopiaY Kebede
Gondar College of Medical Sciences, P.O. Box 196, Gondar, Ethiopia
East Afr Med J 79:274-8. 2002..Additionally, college students need counseling service on ways of coping with their problems...
- Toxicological evaluation of Catha edulis leaves: a long term feeding experiment in animalsMolham Al-Habori
Clinical Biochemistry Department, University of Sana a, PO Box 19065, Sana a, Yemen
J Ethnopharmacol 83:209-17. 2002In this study the long term (6 months) toxicological effect of varying levels of Catha edulis leaves were examined on the plasma concentration of liver enzymes as well as the histopathology of tissue sections of the liver...
- Investigation into the toxicological effects of Catha edulis leaves: a short term study in animalsM Al-Mamary
Food Science Department and Animal Production Department, Faculty of Agriculture, University of Sana'a, Sana'a, Yemen
Phytother Res 16:127-32. 2002In this study the short term (3 months) toxicological effects of varying levels of Catha edulis leaves were examined on the plasma concentration of liver enzymes and the histopathology of tissue sections of various organs including the ..
- Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leavesStefan W Toennes
Institute of Forensic Toxicology, Centre of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
Br J Clin Pharmacol 56:125-30. 2003..The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine...
- [The house of shame and the boys in Akerselva]Willy Pedersen
Tidsskr Nor Laegeforen 127:563. 2007
- [Khat--a new drug of abuse in Norway]Muhammad Al-Samarraie
Divisjon for rettstoksikologi og rusmiddelforskning Nasjonalt folkehelseinstitutt Postboks 4404 Nydalen 0403 Oslo
Tidsskr Nor Laegeforen 127:574-6. 2007..The stimulating drug, Khat, is a drug of abuse that has become known in Norway due to increased immigration from East-Africa, especially Somalia...
- [Khat-induced psychosis?]G Degraeve
Tijdschr Psychiatr 49:763-7. 2007..Two cases of suspected khat-induced psychosis are presented. Treatment of choice appears to be discontinuation of khat use, possibly combined with treatment with an antipsychotic...
- Effect of Catha edulis (khat) on behaviour and its potential to induce seizures in Sprague Dawley ratsE Oyungu
Department of Medical Physiology, Moi University, P O Box 4606, Eldoret, Kenya
East Afr Med J 84:219-25. 2007....
- The perioperative implications of khat useO A Bamgbade
Eur J Anaesthesiol 25:170-2. 2008
- Khat chewing amongst UK resident male Yemeni adults: an exploratory studySaba Kassim
Institute of Dentistry, Queen Mary's School of Medicine and Dentistry, Queen Mary, University of London, UK
Int Dent J 56:97-101. 2006..Further research should investigate the correlations between khat and nicotine dependence. Development of a specific measure of khat dependence is recommended...
- [Evaluation of compliance with antiretroviral treatment in a cohort of 200 patients in Djibouti, 2005]A A Ahmed
Ministere de la Sante, Djibouti
East Mediterr Health J 13:1286-97. 2007..In multivariate analysis, community support and level of education protected against non-compliance. Patients having already missed a dose and those dissatisfied with confidentiality had a 4 times greater risk of non-compliance...
- In vitro effects of crude khat extracts on the growth, colonization, and glucosyltransferases of Streptococcus mutansNezar Noor Al-Hebshi
Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Acta Odontol Scand 63:136-42. 2005..It is shown that khat leaves contain water-soluble constituents that inhibit some cariogenic properties of S. mutans in vitro...
- Khat chewing: an emerging drug concern in Australia?Johana Stefan
Aust N Z J Psychiatry 39:842-3. 2005
- Effects of khat (Catha edulis) consumption on reproductive functions: a reviewJ M Mwenda
Institute of Primate Research, P.O. Box 24481, Karen, Nairobi, Kenya
East Afr Med J 80:318-23. 2003OBJECTIVE: To review research findings on the effects of khat (Catha edulis) chewing on reproductive functions...
- Common drugs of abuse--Part IIMary Linda Stotter Cuddy
J Pract Nurs 54:5-8, 25-31; quiz 17-9. 2004..Drug abuse affects a significant number of individuals of all ages. Health care practitioners must be knowledgeable about both the physiological effects of such drugs and the impact of drug-seeking behavior on their patients...
- A study of 342 oral keratotic white lesions induced by qat chewing among 2500 YemeniAiman A Ali
Department of Oral Pathology and Medicine, Faculty of Dentistry, University of Sana a, Yemen
J Oral Pathol Med 33:368-72. 2004..Various studies demonstrated clear effects of this habit on the systemic organs of the human body. The lack of studies, however, on the effects of this habit on oral mucosa was the major motive of this study...
- Coronary and aortic vasoconstriction by cathinone, the active constituent of khatA L Al-Motarreb
Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cathays Park, Cardiff CF10 3XF, UK
Auton Autacoid Pharmacol 23:319-26. 2003..The precise mechanism for this vasoconstriction remains to be determined. The coronary vasoconstriction may explain the increased incidence of myocardial infarction in khat chewers, which may arise from coronary vasospasm...
- Catha edulis: a new differential in the diagnosis of pregnancy induced hypertensionK M Kuczkowski
J Gynecol Obstet Biol Reprod (Paris) 33:535. 2004
- Anger expression, negative life events and violent behaviour among male college students in EthiopiaBizu Gelaye
Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington 98195, USA
Scand J Public Health 36:538-45. 2008..To assess the prevalence of violent behaviour and to identify risk factors associated with violent behaviour among male college students in Ethiopia...
- Qat chewing and pesticides: a study of adverse health effects in people of the mountainous areas of YemenJunko Date
Graduate School of Medicine, Yamaguchi University, Japan
Int J Environ Health Res 14:405-14. 2004..It is concluded that chewing qat grown with chemical pesticides causes considerable adverse health effects in human beings...
- Determination of cathinone, cathine and norephedrine in hair of Yemenite khat chewersFrank Sporkert
Institute of Legal Medicine, University Rostock, St.-Georg-Street 108, 18055 Rostock, Germany
Forensic Sci Int 133:39-46. 2003..7ng/mg for CTN. A highly significant correlation was found between the self-reported data about the khat consumption habits of the volunteers (4-56h chewing per week) and the concentrations of norephedrine and norpseudoephedrine in hair...
- Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated ratsM Y Banjaw
Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Tuebingen, Germany
J Neural Transm 113:543-56. 2006The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm...
- Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in ratsMehret Yerdaw Banjaw
Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Germany
Behav Brain Res 160:365-73. 2005..inhibition deficit were induced under the same context by intermittent oral administration of S-(-)-cathinone or Catha edulis extract in rats...
- Use of doubly protonated molecules in the analysis of cathedulins in crude extracts of khat (Catha edulis) by liquid chromatography/serial mass spectrometryGeoffrey C Kite
Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK
Rapid Commun Mass Spectrom 17:1553-64. 2003Analysis of crude methanolic extracts of fresh khat (Catha edulis) by liquid chromatography/mass spectrometry (LC/MS) revealed the presence of 62 cathedulin alkaloids (compared with 15 published structures)...
- Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblastsOchiba M Lukandu
Institute of Oral Sciences, Oral Pathology and Forensic Odontology, University of Bergen, and Centre for International Health, University of Bergen, Bergen, Norway
Eur J Oral Sci 116:23-30. 2008..The results show that stress induced by khat modulates the cell cycle in oral keratinocytes and fibroblasts. It is further speculated whether khat could have similar effects in vivo, especially in keratinocytes...
- In vitro antimicrobial and resistance-modifying activities of aqueous crude khat extracts against oral microorganismsNezar Al-hebshi
Laboratory of Oral Microbiology, Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
Arch Oral Biol 51:183-8. 2006To assess antimicrobial activities of aqueous crude khat (Catha edulis) extracts against a panel of oral microorganisms and to test their ability to modify bacterial resistance to tetracycline and penicillin in vitro.
- Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboonJason M Mwenda
Institute of Primate Research, P.O. Box 24481, Karen, Nairobi, Kenya
J Ethnopharmacol 103:379-84. 2006The potential effect of Khat (Catha edulis, Celastraceae) on fertility in humans has not been elucidated...
- Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbitsA W Nyongesa
Department of Veterinary Anatomy and Physiology, University of Nairobi, P O Box 30197, Nairobi, Kenya
J Ethnopharmacol 116:245-50. 2008..This study investigated the effects of fresh khat extract on specific circulating hormones in male rabbits...
- Antifungal efficacy of ten selected South African plant species against Cryptococcus neoformansT A Mokoka
Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort, South Africa
Pharm Biol 48:397-404. 2010..Harv. (Rutaceae), Morusmesozygia Stapf (Moraceae), Calodendrum capense (L.f.) Thunb. (Rutaceae), Catha transvaalensis Codd (Celastraceae), Cussonia zuluensis Strey (Araliaceae), Ochna natalitia (Meisn.) Walp...
- Plants and the central nervous systemE A Carlini
Department of Psychobiology, Paulista School of Medicine, Federal University of Sao Paulo, Rua Botucatu, 862 Ed Ciências Biomédicas, 1o andar, CEP 04023 062, Sao Paulo, SP, Brazil
Pharmacol Biochem Behav 75:501-12. 2003..Ma Huang), Paullinia spp. (guaraná), Catha edulis Forssk. (khat)] and plants used to improve general health conditions (plant adaptogens) were scrutinized...
- Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionizationJochen Beyer
Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
J Mass Spectrom 42:150-60. 2007The herbal stimulants Ephedra species, Catha edulis (khat), and Lophophora williamsii (peyote) have been abused for a long time. In recent years, the herbal drug market has grown owing to publicity on the Internet...
- Prevalence of Helicobacter pylori infection among patients with dyspepsia in South-Western Saudi ArabiaAyobanji E Ayoola
Division of Gastroenterology, King Fahd Central Hospital, Gizan, Kingdom of Saudi Arabia
Saudi Med J 25:1433-8. 2004..Helicobacter pylori (H. pylori) infection is a major cause of various upper gastrointestinal (UGI) disorders. The aim of this study was to determine the prevalence of H. pylori among patients with dyspepsia...
- Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent mannerS A Adeoya Osiguwa
Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King s College London, London, UK
Hum Reprod 22:756-65. 2007..Cathine, an amphetamine-related metabolite of a compound found in Catha edulis leaves, accelerates capacitation and inhibits spontaneous acrosome loss by regulating cAMP production...
- Knowledge and perception of pulmonary tuberculosis in pastoral communities in the middle and Lower Awash Valley of Afar region, EthiopiaMengistu Legesse
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
BMC Public Health 10:187. 2010..In this study, we assessed the knowledge and perception of apparently healthy individuals about pulmonary tuberculosis (PTB) in pastoral communities of Afar...
- Regulation of phagocytosis in macrophages by neuraminidase 1Volkan Seyrantepe
Sainte Justine University Hospital Centre, University of Montreal, Montreal, QuebecH3T 1C5, Canada
J Biol Chem 285:206-15. 2010..and dendritic cells is accompanied by induction of cell-surface neuraminidase 1 (Neu1) and cathepsin A (CathA), the latter forming a complex with and activating Neu1...
- Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future researchA Al-Motarreb
Cardiac Centre, Internal Medicine Department, Sana a University, Sana a, Yemen
J Ethnopharmacol 132:540-8. 2010The leaves of khat (Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their cathinone content...
- Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformationTatsusada Yoshida
Institute of Health Biosciences, The University of Tokushima Graduate School, 1 78 Shomachi, Tokushima 770 8505, Japan
Biochim Biophys Acta 1794:1693-9. 2009Human lysosomal protective protein/cathepsin A (CathA) is a multifunctional protein that exhibits not only protective functions as to lysosomal glycosidases, i.e...
- A pilot study on the effect of catha edulis frosk., (celastraceae) on metabolic syndrome in wokw ratsSamira Abdulla Mahmood
Department of Pharmacology, Faculty of Medicine and Health Sciences, Aden University, Aden, Yemen
Afr J Tradit Complement Altern Med 5:271-7. 2008This study investigated the effect of Catha edulis (khat) on some important parameters of the metabolic syndrome in Wistar Ottawa Karlsburg W (WOKW ) rat...
- Serine carboxypeptidases in regulation of vasoconstriction and elastogenesisAlexey V Pshezhetsky
Department of Medical Genetics, CHU Sainte Justine Research Center, Departments of Pediatrics and Biochemistry, University of Montreal, Montreal, Quebec H3T1C5, Canada
Trends Cardiovasc Med 19:11-7. 2009..The major lysosomal serine carboxypeptidase A (cathepsin A [CathA]), also known as protective protein, activates and stabilizes two other lysosomal enzymes, beta-galactosidase and ..
- Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockadeA A Nasher
Department of Surgery, Faculty of Medicine, University of Sana a, Republic of Yemen
Br J Urol 75:597-8. 1995To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
- Introduction to the special issue: The changing use and misuse of khat (Catha edulis)-Tradition, trade and tragedyMichael Odenwald
University of Konstanz, Fachbereich Psychologie, P O BOX 5560 25, 78457 Konstanz, Germany
J Ethnopharmacol 132:537-9. 2010..This special issue of the Journal of Ethnopharmacology contains articles written by different conference speakers that present the current state of knowledge and the challenges for future research and politics...
- Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1Volkan Seyrantepe
Department of Medical Genetics, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
Circulation 117:1973-81. 2008Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against ..
- Stabilizing effect of lysosomal beta-galactosidase on the catalytic activity of protective protein/cathepsin A secreted by human plateletsK Itoh
Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science, Japan
Biochem Biophys Res Commun 253:228-34. 1998The 32/20-kDa two-chain form of protective protein/cathepsin A (CathA) secreted by human platelets was thermostable in the aggregation supernatant at acidic pH, but was denatured at neutral pH...
- Concentration levels of essential and non-essential metals in Ethiopian khat (Catha edulis Forsk)Minaleshewa Atlabachew
Department of Chemistry, Faculty of Science, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
Biol Trace Elem Res 138:316-25. 2010..Mg, Mn, Fe, Zn, Cr, Cu, and Co) and non-essential (Cd and Pb) metal in six different varieties of Ethiopian khat (Catha edulis Forsk, an evergreen stimulant plant) commonly consumed in the country and exported to the neighboring ..
- Drug use in a rural secondary school in KenyaDavid M Ndetei
Department of Psychiatry, University of Nairobi, Nairobi, Kenya
Subst Abus 31:170-3. 2010..Alcohol, tobacco, khat (catha edulis) and bhang (cannabis) were the most commonly reported substance of use, with user prevalence rates of 5...
- Regular Khat (Catha edulis) chewing is associated with elevated diastolic blood pressure among adults in Butajira, Ethiopia: a comparative studyWorkineh Getahun
School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia
BMC Public Health 10:390. 2010Fresh leaves and buds of the Khat plant (Catha edulis) contain Cathinone, an amphetamine like alkaloid responsible for its pharmacological action...
- Prevalence and risk factors of gender-based violence committed by male college students in Awassa, EthiopiaMarc Philpart
University of Washington, Seattle, WA 98195, USA
Violence Vict 24:122-36. 2009..Alcohol consumption, khat use (Catha edulis, a natural stimulant), combined use of alcohol and khat, and witnessing parental violence were risk factors ..
- Khat use and monitoring drug use in Europe: the current situation and issues for the futurePaul Griffiths
European Monitoring Centre for Drugs and Drug Addiction EMCDDA, Cais do Sodré, 1249 289 Lisbon, Portugal
J Ethnopharmacol 132:578-83. 2010To review the information available on the use of khat (Catha edulis) in the EU, and to assess the future use of this drug and related substances.
- The use of cyclohexanone as a "derivatizing" reagent for the GC-MS detection of amphetamines and ephedrines in seizures and the urineB M El-Haj
Sharjah Police Forensic Science Laboratory, P.O. Box 29, Sharjah, United Arab Emirates
Forensic Sci Int 135:16-26. 2003....
- The effect of khat chewing on gallbladder motility in a group of volunteersN Murugan
Department of Gastroenterology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
J Ethnopharmacol 86:225-7. 2003..are thought to be responsible but other local factors may contribute such as chewing the leaves of the khat plant (Catha edulis Forsk.) which is a widespread social custom in Yemen...
- Determination of cadmium, lead, copper and zinc in Yemeni khat by anodic stripping voltammetryM H Matloob
Department of Chemistry, College of Science for Girls, University of Babylon, Babylon, Iraq
East Mediterr Health J 9:28-36. 2003..0-10.2 microg/day, 23.6-118.0 microg/day, 530-2654 microg/day and 662-3311 microg/day respectively. Although high, these values were within Food and Agriculture Organization/World Health Organization tolerance limits...
- Extraction and microencapsulation of khat: effects on sexual motivation and estradiol level in female ratsHesham Abdul Aziz
Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang
J Sex Med 6:682-95. 2009Khat (Catha edulis) is an evergreen tree/shrub that is thought to affect sexual motivation or libido. Its positive effect on sexual desire is more frequently observed in females than in males and occurs when khat is chewed...
- [Speed drugs]Wojciech Piekoszewski
Zakład Chemii Analitycznej, Uniwersytet Jagiellonski, Krakow
Przegl Lek 66:861-5. 2009..The article discussed the sources and biological action of these psychoactive substances, which are illegal in Poland...
- FTIR spectroscopic, thermal and XRD characterization of hydroxyapatite from new natural sourcesAbdallah A Shaltout
Spectroscopy Department, Physics Division, National Research Center, Dokki, Cairo, Egypt
Spectrochim Acta A Mol Biomol Spectrosc 83:56-60. 2011..These plants are Catha edulis (Khat), basil, mint, green tea and trifolium...
- Cathinone derivatives: a review of their chemistry, pharmacology and toxicologyJohn P Kelly
Department of Pharmacology and Therapeutics, NUI Galway, Galway, Ireland
Drug Test Anal 3:439-53. 2011..It can be assumed that, despite their illegal status, cathinone-related compounds will continue to be prevalent drugs of abuse for the foreseeable future...
- Multi residue analysis of pesticides in wheat and khat collected from different regions of EthiopiaDaniel Daba
Department of Pharmaceutical Chemistry, School of Pharmacy, Jimma University, Jimma, Ethiopia
Bull Environ Contam Toxicol 86:336-41. 2011..8 and 125.6 μg/Kg, respectively) and aldrin levels in these samples were below the quantification limit. Khat may be a contributing factor in the pathological diseases found among khat users...
- Trauma, khat and common psychotic symptoms among Somali immigrants: a quantitative studyKamaldeep Bhui
Queen Mary University of London, Centre for Psychiatry, Old Anatomy Building, Charterhouse Square, London EC1M6BQ, United Kingdom
J Ethnopharmacol 132:549-53. 2010..To undertake this work in a Somali population of emigrants who have sought asylum in a non-conflict zone country...
- Surgical reconstruction of the temporomandibular joint for chronic subluxation and dislocationR Kummoona
Department of Maxillofacial Surgery, College of Dentistry, University of Baghdad, Iraq
Int J Oral Maxillofac Surg 30:344-8. 2001..It may be used for treatment of patients with chronic subluxation and dislocation of the temporomandibular joint...
- Methanol fractionations of Catha edulis Frosk (Celastraceae) contracted Lewis rat aorta in vitro: a comparison between crimson and green leavesSamira Abdulla Mahmood
Department of Pharmacology, Faculty of Medicine and Health Sciences, Aden University, Aden, Yemen
Afr J Tradit Complement Altern Med 6:268-74. 2009..1%; p = 0.06. In conclusion, fractions of green and crimson Yemeni khat leaves contracted aortas of Lewis rats. Both leaves behave almost similarly. Contraction induced by chloroform fraction produced alpha-sympathetic activity...
- Khat (Catha edulis) alters the phenotype and anti-microbial activity of peripheral blood mononuclear cellsCraig Murdoch
Academic Unit of Oral and Maxillofacial Medicine and Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
J Ethnopharmacol 138:780-7. 2011..This study examined the biological effects of khat on the phenotype and function of peripheral blood mononuclear cells (PBMCs)...
- Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicityDavid M Wood
Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
J Med Toxicol 6:327-30. 2010Cathinone is a pharmacologically active alkaloid that can be extracted from the leaves of the khat plant (Catha edulis)...
- Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptidesBhawanjit K Brar
The Clayton Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Endocrinology 145:1718-29. 2004..the regulation of ERK1/2-p42, 44 by Ucn-I were extended to cell lines that endogenously express CRFR1 (AtT-20 and CATHa cells) and CRFR2 (A7r5 and CATHa cells)...
- Methcathinone: a new postindustrial drugHafid Belhadj-Tahar
Groupe Santé Recherche, 35 rue Bernard de Ventadour, 31300 Toulouse, France
Forensic Sci Int 153:99-101. 2005..It is a stimulant found in the "khat" plant, Catha edulis, which can easily be synthesized from pseudoephedrine...
- Effect of khat chewing on 14 selected periodontal bacteria in sub- and supragingival plaque of a young male populationN N Al-Hebshi
Department of Odontology Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
Oral Microbiol Immunol 20:141-6. 2005The habit of chewing khat (Catha edulis) for its amphetamine-like effects is highly prevalent in Yemen and east Africa, and has expanded to Western countries...
- Substance abuse and the risk of readmission of people with schizophrenia at Amanuel Psychiatric Hospital, EthiopiaM S Bimerew
University of the Western Cape, Department of Nursing, Private Bag X 17, Belville, 7535
Curationis 30:74-81. 2007..Raising community awareness, psycho-education, strengthening the capacities of caretakers and laws to prevent substance abuse, as well as campaigning to prevent people from abusing mentally ill sufferers, should be established...