saponaria

Summary

Summary: A plant species of the family CARYOPHYLLACEAE. It is a source of SAPONINS. The common name "Soapwort" is also used with VACCARIA. The common name of "Bouncing Bet" is occasionally used with VIOLA.

Top Publications

  1. ncbi Expression and characterisation in E. coli of mutant forms of saporin
    Eugenia Pittaluga
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio Coppito, 67100 L Aquila, Italy
    J Biotechnol 117:263-6. 2005
  2. ncbi Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N OW9
    Phytochem Anal 17:414-23. 2006
  3. pmc Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
    Dauenpen Meesapyodsuk
    Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N OW9
    Plant Physiol 143:959-69. 2007
  4. doi Saponaria officinalis karyology and karyotype by means of image analyzer and atomic force microscopy
    S Di Bucchianico
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Microsc Res Tech 71:730-6. 2008
  5. ncbi [The hypolipidemic action of the complex emulgator-stabilizer on the basis of laminal and a water extract from roots of alien Saponaria officinalis L. in experiment on the rat]
    T P Iudina
    Vopr Pitan 77:76-9. 2008
  6. ncbi Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium
    J L Turner
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 80:1939-46. 2002
  7. doi Feeding saponin-containing Yucca schidigera and Quillaja saponaria to decrease enteric methane production in dairy cows
    L Holtshausen
    Agriculture and Agri Food Canada, Lethbridge, Alberta, Canada T1J 4B1
    J Dairy Sci 92:2809-21. 2009
  8. ncbi Specific interaction between tetrandrine and Quillaja saponins in promoting permeabilization of plasma membrane in human leukemic HL-60 cells
    Y M Leung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Biochim Biophys Acta 1325:318-28. 1997
  9. ncbi Revision of some Thecaphora species (Ustilaginomycotina) on Caryophyllaceae
    Kálmán Vánky
    Herbarium Ustilaginales Vánky HUV, Gabriel Biel Str 5, D 72076 Tubingen, Germany
    Mycol Res 111:1207-19. 2007
  10. ncbi Vaccination against Strongyloides venezuelensis with homologue antigens using new immunomodulators
    Johnny Vlaminck
    Laboratorio de Parasitologia, Facultad de Farmacia, CIETUS, Universidad de Salamanca, Avda Licenciado Méndez Nieto, 37007 Salamanca, Spain
    J Parasitol 96:643-7. 2010

Research Grants

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Expression and characterisation in E. coli of mutant forms of saporin
    Eugenia Pittaluga
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio Coppito, 67100 L Aquila, Italy
    J Biotechnol 117:263-6. 2005
    ..in Escherichia coli of mutant derivatives of saporin, a type 1 ribosome-inactivating protein from Saponaria officinalis L...
  2. ncbi Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N OW9
    Phytochem Anal 17:414-23. 2006
    ..array and single quadrupole electrospray mass detection for analysis and profiling of bisdesmosidic saponins in Saponaria vaccaria seed was developed...
  3. pmc Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
    Dauenpen Meesapyodsuk
    Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N OW9
    Plant Physiol 143:959-69. 2007
    b>Saponaria vaccaria (Caryophyllaceae), a soapwort, known in western Canada as cowcockle, contains bioactive oleanane-type saponins similar to those found in soapbark tree (Quillaja saponaria; Rosaceae)...
  4. doi Saponaria officinalis karyology and karyotype by means of image analyzer and atomic force microscopy
    S Di Bucchianico
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Microsc Res Tech 71:730-6. 2008
    The aim of this work was to offer a contribution to the characterization of taxonomic entity of Saponaria officinalis (2n = 28; an herbaceous perennial species; saporin, a type 1 Ribosome Inactivating Protein, is present in leaves and ..
  5. ncbi [The hypolipidemic action of the complex emulgator-stabilizer on the basis of laminal and a water extract from roots of alien Saponaria officinalis L. in experiment on the rat]
    T P Iudina
    Vopr Pitan 77:76-9. 2008
    ..action of the complex emulgator-stabilizer (CES) on the basis of a water extract from roots of strange (alien) Saponaria officinalis L and laminal in the ratio 1:1,5 has been made...
  6. ncbi Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium
    J L Turner
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 80:1939-46. 2002
    ..9 kg and 24 d of age) were used in a 28-d experiment to determine the effects of Quillaja saponaria extract (QS) on weanling pig growth performance and immune function in response to enteric disease challenge ..
  7. doi Feeding saponin-containing Yucca schidigera and Quillaja saponaria to decrease enteric methane production in dairy cows
    L Holtshausen
    Agriculture and Agri Food Canada, Lethbridge, Alberta, Canada T1J 4B1
    J Dairy Sci 92:2809-21. 2009
    ..was conducted in vitro to determine whether the addition of saponin-containing Yucca schidigera or Quillaja saponaria reduces methane production without impairing ruminal fermentation or fiber digestion...
  8. ncbi Specific interaction between tetrandrine and Quillaja saponins in promoting permeabilization of plasma membrane in human leukemic HL-60 cells
    Y M Leung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Biochim Biophys Acta 1325:318-28. 1997
    ..Exposure of the cells for 5 min to saponins from Quillaja saponaria (QS, 30 microg/ml), surfactants well known to permeabilize the plasma membrane by complexing with cholesterol, ..
  9. ncbi Revision of some Thecaphora species (Ustilaginomycotina) on Caryophyllaceae
    Kálmán Vánky
    Herbarium Ustilaginales Vánky HUV, Gabriel Biel Str 5, D 72076 Tubingen, Germany
    Mycol Res 111:1207-19. 2007
    ..lat. from several caryophyllacean host plants belonging to the genera Cerastium, Dianthus, Petrorhagia, Saponaria, Silene, and Stellaria were studied by means of both LM, SEM, and molecular phylogenetic analyses using ITS and ..
  10. ncbi Vaccination against Strongyloides venezuelensis with homologue antigens using new immunomodulators
    Johnny Vlaminck
    Laboratorio de Parasitologia, Facultad de Farmacia, CIETUS, Universidad de Salamanca, Avda Licenciado Méndez Nieto, 37007 Salamanca, Spain
    J Parasitol 96:643-7. 2010
    ..Moreover, we included saponins from Quillaja saponaria (Qs) and immunomodulatory substances, i.e...
  11. ncbi The effects of Yucca schidigera and Quillaja saponaria on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in streptozotocin-induced diabetic rats
    A Fatih Fidan
    Department of Biochemistry, Faculty of Veterinary Medicine, Afyonkarahisar Kocatepe University, 03200 Afyonkarahisar, Turkey
    J Diabetes Complications 22:348-56. 2008
    The aim of this study was to examine the effects of Yucca schidigera, Quillaja saponaria, and a mixture of both plants on streptozotocin-induced diabetic rats. Animals were allocated into five groups with 10 rats each...
  12. ncbi Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
    D J Marciani
    Galenica Pharmaceuticals, Inc, Frederick, MD 21701, USA
    Int Immunopharmacol 1:813-8. 2001
    ....
  13. ncbi Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body
    Sang Woo Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Miz Medi Hospital, Seoul, Korea
    Arch Pharm Res 26:1042-6. 2003
    This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new ..
  14. ncbi Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity
    P N Boyaka
    Department of Microbiology, University of Alabama, Medical Center, Birmingham, AL 35294, USA
    J Immunol 166:2283-90. 2001
    The highly purified saponin derivative, QS-21, from the Quillaja saponaria Molina tree has been proved to be safe for parenteral administration and represents a potential alternative to bacterial enterotoxin derivatives as a mucosal ..
  15. ncbi High efficiency Agrobacterium rhizogenes-mediated transformation of Saponaria vaccaria L. (Caryophyllaceae) using fluorescence selection
    Janice F Schmidt
    Plant Biotechnology Institute, 110 Gymnasium Place, S7N OW9 Saskatoon, SK, Canada
    Plant Cell Rep 26:1547-54. 2007
    ..efficient and convenient method for the Agrobacterium rhizogenes-dependent production of transformed roots of Saponaria vaccaria L. (Caryophyllaceae) is described. The parameters tested and optimized include S...
  16. doi Multidimensional profiling of components in complex mixtures of natural products for metabolic analysis, proof of concept: application to Quillaja saponins
    Johan Bankefors
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 878:471-6. 2010
    ..described procedure has proven useful to discern several hundreds of saponin components when applied to Quillaja saponaria Molina bark extracts...
  17. doi A trypsin inhibitor from Sapindus saponaria L. seeds: purification, characterization, and activity towards pest insect digestive enzyme
    Maria Ligia R Macedo
    Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Tecnologia de Alimentos e Saúde Pública, Centro de Ciencias Biologicas e da Saude, Universidade Federal do Mato Grosso do Sul UFMS, Cidade Universitária s n, Caixa Postal 549, Campo Grande, MS, CEP 79070 900, Brazil
    Protein J 30:9-19. 2011
    ..SSTI showed significant inhibitory activity against trypsin-like proteases present in the larval midgut on Anagasta kuehniella, Corcyra cephalonica, Diatreae saccharalis and Anticarsia gemmatalis...
  18. pmc Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A)
    L Barbieri
    Dipartimento di Patologia sperimentale dell Università degli Studi di Bologna Via San Giacomo 14, I 40126 Bologna, Italy
    Nucleic Acids Res 25:518-22. 1997
    ..Recently we have shown that the RIP from Saponaria officinalis have a much wider substrate specificity: they are actually polynucleotide:adenosine glycosidases...
  19. doi Evaluation of antioxidant, antinociceptive, and anti-inflammatory activities of ethanol extracts from Aloe saponaria Haw
    Eun Ah Yoo
    Laboratory of Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
    Phytother Res 22:1389-95. 2008
    ..b>saponaria Haw...
  20. pmc Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin
    F Poccia
    Department of Biology, University of Rome Tor Vergata, Italy
    Br J Cancer 66:427-32. 1992
    ..Moreover, the MoAb ML30 was coupled to Saporin 6, a ribosome-inactivating protein recovered from the seeds of Saponaria officinalis, to kill HSP-expressing cells with a specific immunotoxin...
  21. ncbi Antiulcer activity of Sapindus saponaria L. in the rat
    Adriana L Meyer Albiero
    Department of Pharmacy and Pharmacology, Universidade Estadual de Maringa, PR Avenida Colombo, 5790 CEP 87020 900, Maringa, PR, Brazil
    J Ethnopharmacol 82:41-4. 2002
    Extracts of leaves and fruits of Sapindus saponaria L. were orally administered to rats and the parameters of gastric secretion (volume, pH and acidity) were evaluated after pylorus ligature...
  22. ncbi ISCOMs: an adjuvant with multiple functions
    A Sjolander
    Immunology Department, CSL Limited, Parkville, Melbourne, Australia
    J Leukoc Biol 64:713-23. 1998
    ..about 40 nm that are built up by cholesterol, lipid, immunogen, and saponins from the bark of the tree Quillaia saponaria Molina...
  23. ncbi Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 21:1136-42. 2006
    ..The present study was performed to explore the initial involvement of macrophages in the development of T-cell-mediated chronic colitis...
  24. ncbi Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA
    L Barbieri
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo, 14, I 40126, Bologna, Italy
    Biochim Biophys Acta 1480:258-66. 2000
    Saporin-L1 from the leaves of Saponaria officinalis belongs to a group of plant polynucleotide:adenosine glycosidases, known as ribosome-inactivating proteins due to their property of depurinating the major rRNA...
  25. ncbi Surface shear rheology of saponin adsorption layers
    Konstantin Golemanov
    Department of Chemical Engineering, Faculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria
    Langmuir 28:12071-84. 2012
    ..Langmuir 2011, 27, 12486-12498), we showed that the triterpenoid saponins extracted from Quillaja saponaria plant (Quillaja saponins) formed adsorption layers with unusually high surface dilatational elasticity, 280 ± ..
  26. ncbi Immunomodulation of the response to excretory/secretory antigens of Fasciola hepatica by Anapsos in Balb/C mice and rat alveolar macrophages
    Julio López-Abán
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Salamanca, Avda Campo Charro s n, 37007 Salamanca, Spain
    J Parasitol 93:428-32. 2007
    ..In this work we assess the effect of Anapsos and ESFh and Quillaja saponaria extract (Qs) on BALB/c mice and rat alveolar macrophages...
  27. ncbi Effects of Sapindus saponaria fruits on ruminal fermentation and duodenal nitrogen flow of sheep fed a tropical grass diet with and without legume
    A Abreu
    Department of Animal Production, National University of Colombia, Bogota, Colombia
    J Anim Sci 82:1392-400. 2004
    ..6% CP, DM basis) in a 3:1 ratio (DM basis). In addition, 0 or 8 g of DM of Sapindus saponaria fruits (12.0% crude saponins, DM basis) per kilogram of metabolic BW was administered intraruminally...
  28. ncbi Application of Quillaja saponaria extracts as oral adjuvants for plant-made vaccines
    Dwayne D Kirk
    Arizona State University, School of Life Sciences, Mail Code 4501, Tempe, Arizona 85287 4501, USA
    Expert Opin Biol Ther 4:947-58. 2004
    Extracts from the Quillaja saponaria tree are known to provide immune potentiating responses and, hence, can be useful as adjuvants...
  29. ncbi Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis
    Bernadete Pereira da Silva
    Laboratório de Química de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, P O Box 68045, CEP 21944 970 Rio de Janeiro, Brazil
    Vaccine 23:1061-71. 2005
    ..shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina)...
  30. ncbi Vaccination of mice and sheep with Fh12 FABP from Fasciola hepatica using the new adjuvant/immunomodulator system ADAD
    A R Martinez-Fernandez
    Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense, Pza Ramón y Cajal s n, 28040 Madrid, Spain
    Vet Parasitol 126:287-98. 2004
    ..The first injection contains a micelle in which two components are included, saponin from Quillaja saponaria (Qs) and/or Anapsos (A) a Polypodium leucotomos hydroalcoholic extract, both emulsified in a non-mineral oil (..
  31. ncbi Role of Myzus persicae (Hemiptera: Aphididae) and its secondary hosts in plum pox virus propagation
    B Manachini
    Institute of Agricultural Entomology, University of Milan, via Celoria 2 1, 20133 Milan, Italy
    J Econ Entomol 100:1047-52. 2007
    ..The results indicate that Saponaria ocymoides L., Pisum sativum L., Trifolium repens L., Trifolium pratense L., Lepidium sativum L...
  32. ncbi Effects of quillaja saponin (Quillaja saponaria) on early embryonic zebrafish (Danio rerio) development
    Sherif M Hassan
    Poultry Science Department, College of Agriculture and Life Sciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Int J Toxicol 27:273-8. 2008
    ..Quillaja saponin, extracted from bark of the tree, Quillaja saponaria, is a common foaming agent used in foods and beverages...
  33. ncbi Differences in X-ray absorption due to cadmium treatment in Saponaria officinalis leaves
    Lucia Reale
    Universita di L Aquila, Dipartimento di Fisica and INFM, INFN LNGS, 67010, Coppito L Aquila, Italy
    Microsc Res Tech 64:21-9. 2004
    A method for detecting cadmium uptake in leaves of Saponaria officinalis doped with a solution of cadmium acetate is described...
  34. ncbi Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine
    Dante J Marcian
    Galenica Pharmaceuticals, Inc, Birmingham, AL 35344, USA
    Int Immunopharmacol 2:1703-11. 2002
    ..Increasing the dose of DS-saponins tenfold resulted in a marginal increase in protection. These results show that degradation of Q. saponins during storage can have a deleterious effect on vaccines' efficacies...
  35. ncbi The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities
    Shveta Bagga
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110067, India
    J Biol Chem 278:4813-20. 2003
    Saporin-6 produced by the plant Saponaria officinalis belongs to the family of single chain ribosome-inactivating proteins...
  36. ncbi Enzymatic specificity of three ribosome-inactivating proteins against fungal ribosomes, and correlation with antifungal activity
    Sang Wook Park
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523, USA
    Planta 216:227-34. 2002
    ..saporin-S6 (from Saponaria officinalis L...
  37. doi Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum
    Ellen De Geyter
    Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Pest Manag Sci 68:164-9. 2012
    ..Four saponins were selected: two triterpene saponins, Q. saponaria saponins and aescin, and two steroidal saponins, digitonin and diosgenin...
  38. ncbi QS-21 structure/function studies: effect of acylation on adjuvant activity
    Gui Liu
    Antigenics Inc, 175 Crossing Boulevard, Framingham, MA 01702 4473, USA
    Vaccine 20:2808-15. 2002
    QS-21 is a natural saponin adjuvant derived from the tree Quillaja saponaria Molina. Previous studies over a limited dose range suggested the acylation is critical to adjuvant activity...
  39. pmc Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria
    Edilson Damke
    Department of Clinical Analysis and Biomedicine, Division of Clinical Cytology, State University of Maringa, Maringa, Paraná 4860, Brazil
    BMC Complement Altern Med 13:196. 2013
    Sapindus saponaria is used traditionally for curing ulcers, external wounds and inflammations. The spermicidal and anti-Trichomonas activity of S. saponaria and its effect on Lactobacillus acidophilus were evaluated.
  40. ncbi [Membranotropic effect of some triterpene glycosides possessing immunostimulating properties]
    I A Lee
    Biofizika 53:462-9. 2008
    ..holotoxin A1 and cucumarioside A2-2, respectively) were studied in comparison with plant saponins from Quillaja saponaria, known as hemolytic, adjuvant, and structure-forming components of immunostimulating complexes...
  41. doi Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
    Sylvia Arrau
    Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
    J Ethnopharmacol 133:164-7. 2011
    Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine.
  42. ncbi Micellar aggregates of saponins from Chenopodium quinoa: characterization by dynamic light scattering and transmission electron microscopy
    S G Verza
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Pharmazie 67:288-92. 2012
    ..Under experimental conditions similar to those reported for the preparation of Quillaja saponaria ISCOM matrices, tubular and ring-like micelles arose from FQ70:CHOL:PC and FQ90:CHOL:PC formulations, ..
  43. ncbi Intramolecular interchain reactions in bidesmosidic glycosides, a new insight into carbohydrate rearrangements induced by electrospray ionisation
    Fabrizio Dal Piaz
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    Rapid Commun Mass Spectrom 21:286-96. 2007
    ..components of widely used herbal drugs and pharmaceutical preparations; ginseng, Tribulus terrestris, Quillaja saponaria, and Digitalis ssp. are just a few examples...
  44. pmc The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme
    Carla J S Barber
    National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada
    J Biol Chem 288:12500-10. 2013
    Caryophyllaceae-type cyclic peptides (CPs) of 5-12 proteinogenic amino acids occur in 10 plant families. In Saponaria vaccaria (Caryophyllaceae), they have been shown to be formed from linear peptide precursors derived from ribosomal ..
  45. pmc Synthesis and structure verification of the vaccine adjuvant QS-7-Api. Synthetic access to homogeneous Quillaja saponaria immunostimulants
    Kai Deng
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 130:5860-1. 2008
    QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bark of Quillaja saponaria. It is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccine ..
  46. ncbi The unusual stability of saporin, a candidate for the synthesis of immunotoxins
    S Santanché
    Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli, Universita di Roma La Sapienza, Italy
    Biochem Biophys Res Commun 234:129-32. 1997
    Saporin, a monomeric protein extracted from the seeds of Saponaria officinalis, is an enzyme capable of specific depurination of the eukaryotic ribosomes...
  47. ncbi A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia
    Kathleen Cathcart
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 103:1037-42. 2004
    ..phase 2 trial, 14 patients with CML in chronic phase were vaccinated with 6 fusion peptides mixed with Quillaja saponaria (QS-21). No significant toxic effects were observed...
  48. ncbi Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation
    M Cecilia Sampedro
    Departamento de Química Biológica CIQUIBIC, Facultad Ciencias Quimicas, Universidad Nacional de Cordoba, Cuidad Universitaria, C5000GYA Córdoba 5016, Argentina
    Int Immunopharmacol 4:411-8. 2004
    In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines...
  49. pmc Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)
    F Stirpe
    Biochem J 216:617-25. 1983
    ..to those already known [Barbieri & Stirpe (1982) Cancer Surveys 1, 489-520] were purified from the seeds of Saponaria officinalis (two proteins), of Agrostemma githago (three proteins), and of Asparagus officinalis (three proteins)..
  50. ncbi Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein from Saponaria officinalis
    C Savino
    Department of Biochemical Sciences and CNR, Centre for Molecular Biology, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Acta Crystallogr D Biol Crystallogr 54:636-8. 1998
    ..53 and c = 119. 67 A, and diffract to 2.0 A resolution on a rotating-anode X-ray source. The asymmetric unit contains one molecule, corresponding to a volume of the asymmetric unit per unit mass (Vm) of 2.38 A3 Da-1...
  51. ncbi The use of commercial saponin from Quillaja saponaria bark as a natural larvicidal agent against Aedes aegypti and Culex pipiens
    D Pelah
    The Institutes for Applied Research, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Ethnopharmacol 81:407-9. 2002
    The larvicidal activity of commercial bark saponin extract (Sigma) from Quillaja saponaria was studied on 3rd-4th instar larvae of Aedes aegypti and Culex pipiens (vectors for dengue fever and Western Nile virus, respectively)...
  52. ncbi Effect of dietary saponins from Quillaja saponaria L. on fatty acid composition and cholesterol content in muscle Longissimus dorsi of lambs
    D M R Brogna
    1University of Catania, Dipartimento di Scienze delle Produzioni Agrarie e Alimentari, Via Valdisavoia 5, 95123, Catania, Italy
    Animal 5:1124-30. 2011
    The purpose of this study was to evaluate the effects of increasing levels of saponins from Quillaja saponaria on fatty acid (FA) composition and cholesterol content in muscle Longissimus dorsi of lambs...
  53. pmc Effects of saponins against clinical E. coli strains and eukaryotic cell line
    Michał Arabski
    Department of Microbiology, Institute of Biology, Jan Kochanowski University in Kielce, Kielce, Poland
    J Biomed Biotechnol 2012:286216. 2012
    ..In this study, the effects of saponins from Quillaja saponaria were analyzed against prokaryotic and eukaryotic cells. Multidrug-resistant clinical E...
  54. doi Diversity of foliar endophytic fungi from the medicinal plant Sapindus saponaria L. and their localization by scanning electron microscopy
    Adriana Garcia
    Department of Cell Biology and Genetics, Universidade Estadual de Maringa, Brasil
    Biol Res 45:139-48. 2012
    ..In folk medicine, the bark, roots and fruits of Sapindus saponaria is used to produce substances with anxiolytic, astringent, diuretic and expectorant properties, as well as ..
  55. ncbi An immunotoxin containing a rat IgM monoclonal antibody (Campath 1) and saporin 6: effect on T lymphocytes and hemopoietic cells
    P L Tazzari
    Istituto di Ematologia L and A Seragnoli, Bologna, Italy
    Cancer Immunol Immunother 26:231-6. 1988
    ..We used saporin 6 purified from Saponaria officinalis seeds, which was conjugated with the rat IgM monoclonal antibody Campath 1 specific for mature T and ..
  56. doi Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria
    Marcos L da Silva
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, UNAERP, Ribeirao Preto SP, Brazil
    Pharm Biol 50:366-75. 2012
    Sapindus saponaria L. (Sapindaceae) bark, root, and fruits are used as sedatives and to treat gastric ulcer and also demonstrate diuretic and expectorant effects.
  57. doi Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice
    Mayank Thakur
    Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Mol Oncol 7:475-83. 2013
    ..1 μg Sap3-EGF per treatment. A more than 90% reduction (p < 0.05) in the average tumor volume was observed by this combined therapy...
  58. doi Ultrasonically enhanced extraction of bioactive principles from Quillaja Saponaria Molina
    L Gaete-Garretón
    Laboratorio de Ultrasonidos, Departamento de Fisica, Universidad de Santiago de Chile, Av Ecuador 3493, 917 0124 Santiago, Chile
    Ultrasonics 51:581-5. 2011
    A study of ultrasonic enhancement in the extraction of bioactive principles from Quillaja Saponaria Molina (Quillay) is presented. The effects influencing the extraction process were studied through a two-level factorial design...
  59. pmc Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins
    Govind Ragupathi
    Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, 1275 York Avenue, New York, NY 10065, USA
    Vaccine 28:4260-7. 2010
    The saponin fraction QS-21 from Quillaja saponaria has been demonstrated to be a potent immunological adjuvant when mixed with keyhole limpet hemocyanin conjugate vaccines, as well as with other classes of subunit antigen vaccines...
  60. doi Alum-type adjuvant effect of non-haemolytic saponins purified from Ilex and Passiflora spp
    F Silveira
    Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Desarrollo Biotecnológico Departamento de Química Orgánica, Facultad de Medicina Química, Instituto de Higiene, Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay
    Phytother Res 25:1783-8. 2011
    ..Mice were immunized twice with TT formulated with pure saponins 1-5, or with a mixture of saponins from Quillaja saponaria, aluminum hydroxide gel or saline, which were used as controls...
  61. ncbi QS-21 and QS-7: purified saponin adjuvants
    C R Kensil
    Aquila Biopharmaceuticals, Inc, Worcester, MA, USA
    Dev Biol Stand 92:41-7. 1998
    QS-21 and QS-7 are two adjuvant-active saponins that can be obtained in high purity from Quillaja saponaria Molina extracts...
  62. pmc Prevention of rotavirus infections in vitro with aqueous extracts of Quillaja Saponaria Molina
    Michael R Roner
    University of Texas at Arlington, Department of Biology, Arlington, TX 76010, USA
    Future Med Chem 2:1083-97. 2010
    ..We believe that saponins will 'coat' the epithelium of the host's small intestine and prevent attachment of rotavirus...
  63. ncbi The plant ribosome inactivating protein saporin induces micronucleus formation in peripheral human lymphocytes in vitro
    A Poma
    Department of Basic and Applied Biology, Faculty of Sciences, University of L Aquila, Italy
    Toxicol Lett 105:67-73. 1999
    ..In this work we analyzed the genotoxic effects of saporin, purified from root cultures of Saponaria officinalis, by evaluating micronucleus formation and by the quantitative determination of cytosolic histone-..
  64. pmc Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index
    Kefei Hu
    Department of Medical Sciences, Section of Virology, Uppsala University, Uppsala, Sweden
    Int J Nanomedicine 5:51-62. 2010
    Saponin fractions of Quillaja saponaria Molina (QS) have cytotoxic activity against cancer cells in vitro, but are too toxic to be useful in the clinic...
  65. ncbi Preparation and characterisation of quillaja saponin with less heterogeneity than Quil-A
    S Kamstrup
    Danish Veterinary Institute for Virus Research, Lindholm, DK 4771, Kalvehave, Denmark
    Vaccine 18:2244-9. 2000
    ..One such type of adjuvant is saponin derived from the bark of Quillaja saponaria Molina, a tree of the rose family...
  66. pmc Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein
    Matthew B Sturm
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 48:9941-8. 2009
    ..We characterized the catalytic properties of saporin-L1 from Saponaria officinalis (soapwort) leaves, and it demonstrated robust activity against defined nucleic acid substrates and ..
  67. ncbi Saporin suicide gene therapy
    Natasa Zarovni
    Department of Biological and Technological Research, DIBIT, San Raffaele H Scientific Institute, Milano, Italy
    Methods Mol Biol 542:261-83. 2009
    ..Plasmids expressing a cytosolic saporin (SAP) gene from common soapwort (Saponaria officinalis) are generated by placing the region encoding the mature plant toxin under the control of strong ..
  68. doi Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives
    Maité Rodríguez-Díaz
    Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
    J Pharm Pharmacol 63:718-24. 2011
    Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol...
  69. pmc Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
    Govind Ragupathi
    Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Expert Rev Vaccines 10:463-70. 2011
    ..immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria)...
  70. ncbi Isolation and quantification of Quillaja saponaria Molina saponins and lipids in iscom-matrix and iscoms
    S Behboudi
    Swedish University of Agricultural Sciences, Department of Veterinary Microbiology, Uppsala
    Vaccine 13:1690-6. 1995
    ..The procedures described should also be useful to adequately define constituents in prospective vaccines...
  71. pmc Immunotoxins and other conjugates containing saporin-s6 for cancer therapy
    Letizia Polito
    Department of Experimental Pathology, Alma Mater Studiorum University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Toxins (Basel) 3:697-720. 2011
    ..Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L...
  72. doi Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines
    Ellen De Geyter
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Insect Physiol 58:18-23. 2012
    ..In continuation, it was of interest that (4) a trypan blue assay with Q. saponaria saponin confirmed the cell membrane permeation effect leading to cell toxicity with a median lethal ..
  73. doi Antiproliferative activity of Saponaria vaccaria constituents and related compounds
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada
    Fitoterapia 83:170-81. 2012
    Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth ..
  74. ncbi Liquid-chromatographic profiling of Saponinum album (Merck)
    A Weng
    Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charite Universitatsmedizin, Berlin, Germany
    Pharmazie 66:744-6. 2011
    ..that Saponinum album (Merck) dramatically enhances the toxicity of the N-glycosylase saporin from the seeds of Saponaria officinalis L. as well as the toxicity of a saporin based anti-tumor toxin...
  75. doi Composition of epiphytic bacterial communities differs on petals and leaves
    R R Junker
    Department of Animal Ecology and Tropical Biology, University of Wurzburg, Biozentrum, Wurzburg, Germany
    Plant Biol (Stuttg) 13:918-24. 2011
    ..We identified bacteria isolated from the surface of petals and leaves of two plant species, Saponaria officinalis (Caryophyllaceae) and Lotus corniculatus (Fabaceae)...
  76. doi Surface rheology of saponin adsorption layers
    R Stanimirova
    Department of Chemical Engineering, Faculty of Chemistry, Sofia University, 1 J Bourchier Avenue, 1164 Sofia, Bulgaria
    Langmuir 27:12486-98. 2011
    Extracts of the Quillaja saponaria tree contain natural surfactant molecules called saponins that very efficiently stabilize foams and emulsions. Therefore, such extracts are widely used in several technologies...
  77. pmc Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata
    A M Di Massimo
    Menarini Ricerche SpA, Department of Biotechnology, Pomezia, Rome, Italy
    Br J Cancer 75:822-8. 1997
    ..linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria pyramidata respectively...
  78. doi Electrospray ionization ion-trap multiple-stage mass spectrometry of Quillaja saponins
    Johan Bankefors
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Mass Spectrom 46:658-65. 2011
    Fifteen identified C-18 fatty acyl-containing saponin structures from Quillaja saponaria Molina have been investigated by electrospray ionization ion-trap multiple-stage mass spectrometry (ESI-IT-MS(n)) in positive ion mode...
  79. ncbi The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors
    Janet A Condie
    Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK S7NOW9, Canada
    Plant J 67:682-90. 2011
    ..A collection of expressed sequence tags from developing seeds of Saponaria vaccaria was investigated for information about CP biosynthesis...
  80. pmc Characterization of in vivo anti-rotavirus activities of saponin extracts from Quillaja saponaria Molina
    Ka Ian Tam
    The University of Texas Arlington, Department of Biology, Arlington, TX 76019, USA
    Antiviral Res 90:231-41. 2011
    ..We believe that Quillaja extracts have promise as antivirals to reduce rotavirus infection and the severity of the disease in humans...
  81. pmc In vivo activity of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida species
    Edilson Damke
    Department of Clinical Analysis and Biomedicine, State University of Maringa, Parana, Brazil
    BMC Complement Altern Med 11:35. 2011
    Study of in vivo antifungal activity of the hydroalcoholic extract (HE) and n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida spp.
  82. ncbi Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity
    D J Marciani
    Galenica Pharmaceuticals, Inc, Frederick, MD 21701, USA
    Vaccine 18:3141-51. 2000
    Aldehyde-containing triterpene saponins have adjuvant properties, but only those from Quillaja saponaria Molina stimulate the production of cytotoxic T lymphocytes (CTL) against exogenous antigens...
  83. ncbi [Reproductive phenology and flower anatomy of the plants Aloe vera and Aloe saponaria (Aloaceae) in Cumana, Venezuela]
    Róger Velásquez-Arenas
    Centro de Investigaciones Ecológicas Guayacán CIEGUDO, Hebario IRBR, Universidad de Oriente, Nucleo de Sucre, Cumana 6101, Venezuela
    Rev Biol Trop 56:1109-25. 2008
    ..A. vera flowered between December and May; A. saponaria from November through August. In both species, the anthesis lasted 48 h...
  84. doi In vitro efficacies of oils, silicas and plant preparations against the poultry red mite Dermanyssus gallinae
    Veronika Maurer
    Research Institute of Organic Agriculture FiBL, Ackerstrasse, 5070, Frick, Switzerland
    Exp Appl Acarol 48:31-41. 2009
    ..derived from Chrysanthemum cineariaefolium, Allium sativum, Tanacetum vulgare, Yucca schidigera, Quillaja saponaria, Dryopteris filix-mas, and Thuja occidentalis) were tested at various concentrations...
  85. ncbi Progress in the development of Fasciola hepatica vaccine using recombinant fatty acid binding protein with the adjuvant adaptation system ADAD
    J López-Abán
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Salamanca, Avda Campo Charro s n, 37007 Salamanca, Spain
    Vet Parasitol 145:287-96. 2007
    ..immunomodulator (hydroalcoholic extract of Polypodium leucotomos; PAL) and/or an adjuvant (saponins of Quillaja saponaria; Qs) in a water/oil emulsion (30/70) with a non-mineral oil (Montanide)...
  86. ncbi Protective vaccination against murine visceral leishmaniasis using aldehyde-containing Quillaja saponaria sapogenins
    C B Palatnik de Sousa
    Instituto de Microbiologia, Prof Paulo de Góes, Universidade Federal do Rio de Janeiro UFRJ, CCS, Cidade Universitaria, Ilha do Fundao, CP 68040, CEP 21941 590, Rio de Janeiro, RJ, Brazil
    Vaccine 22:2470-9. 2004
    ..336) and Quillaja saponaria QuilA saponin (delta 9.348)...
  87. ncbi Oligosaccharide sequences in Quillaja saponins by electrospray ionization ion trap multiple-stage mass spectrometry
    Susanna Broberg
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Mass Spectrom 39:691-701. 2004
    Ten different samples with 13 previously identified saponin structures from Quillaja saponaria Molina were investigated by electrospray ionization ion trap multiple-stage mass spectrometry (ESI-ITMS(n)) in positive and negative ion modes...
  88. ncbi Antiviral activity obtained from aqueous extracts of the Chilean soapbark tree (Quillaja saponaria Molina)
    Michael R Roner
    Department of Biology, The University of Texas Arlington, Arlington, TX 76019, USA
    J Gen Virol 88:275-85. 2007
    Natural, aqueous extracts of Quillaja saponaria, the Chilean soapbark tree, contain several physiologically active triterpenoid saponins that display strong adjuvant activity when used in either human or animal vaccines...
  89. ncbi Metabolomic analysis of saponins in crude extracts of Quillaja saponaria by liquid chromatography/mass spectrometry for product authentication
    Geoffrey C Kite
    Royal Botanic Gardens, Kew, Richmond TW9 3AB, UK
    Rapid Commun Mass Spectrom 18:2859-70. 2004
    Analysis of 50% aqueous methanolic extracts of bark of Quillaja saponaria Molina (quillaja) by liquid chromatography/mass spectrometry (LC/MS), using negative ion electrospray, revealed over 100 saponins...
  90. ncbi [Toxicity assessment of the vegetable emulsifier- the aqueous extract from the common soapwort roots]
    T P Iudina
    Vopr Pitan 75:50-2. 2006
    ..Comparative analysis of results allows to expel toxic effect AEAR in the recommended dose on an organism of animals...
  91. ncbi Saponins from Quillaja saponaria Molina: isolation, characterization and ability to form immuno stimulatory complexes (ISCOMs)
    Hoang L Pham
    School of Pharmacy, The University of Queensland, Brisbane, Australia
    Curr Drug Deliv 3:389-97. 2006
    ..of phospholipids, cholesterol and Quil A, a crude mixture of saponins extracted from the bark of Quillaja saponaria Molina...
  92. ncbi Assessment of the monoterpene, glycidic and triterpene-moieties' contributions to the adjuvant function of the CP05 saponin of Calliandra pulcherrima Benth during vaccination against experimental visceral leishmaniasis
    D Nico
    Instituto de Microbiologia Prof Paulo de Goes, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, P O Box 68040, CEP 21941 590 Rio de Janeiro, Brazil
    Vaccine 25:649-58. 2007
    The CP05 saponin from Calliandra pulcherrima Benth, shows remarkable similarities to the QS21 saponin of Quillaja saponaria Molina...
  93. pmc Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi
    Yong Jae Kim
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Am Chem Soc 128:11906-15. 2006
    ..The chemical synthesis of QS-21 offers unique opportunities to probe its mode of biological action through the preparation of otherwise unattainable nonnatural saponin analogues...
  94. ncbi Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice
    Juliane D Fleck
    Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul UFRGS, Av Ipiranga, 2752, Porto Alegre 90610 000, RS, Brazil
    Vaccine 24:7129-34. 2006
    ..from Quillaja brasiliensis, a native species from Southern Brazil, show remarkable similarities to Quillaja saponaria saponins which are known as adjuvants in vaccine formulations...
  95. ncbi [Relationship between antibacterial activity of aloe and its anthaquinone compounds]
    Bing Tian
    Department of Applied Bioscience, Institute of Nuclear Agricultural Sciences, Zhejiang University, Hangzhou 310029, Zhejiang, China
    Zhongguo Zhong Yao Za Zhi 28:1034-7. 2003
    ....
  96. ncbi Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis
    E Oliveira-Freitas
    Instituto de Microbiologia Prof Paulo de Goes, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, P O Box 68040, CEP 21941 590 Rio de Janeiro, Brasil
    Vaccine 24:3909-20. 2006
    ..was fractionated by ion exchange chromatography on DEAE-cellulose to afford one TLC homogeneous Quillaja saponaria Molina QS21 saponin fraction (18.0%), a mixture of two deacylsaponins (19.4%), sucrose (39...
  97. ncbi Microspore embryogenesis and the development of a double haploidy protocol for cow cockle (Saponaria vaccaria)
    Zoë Kernan
    National Research Council Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK S7N 0W9, Canada
    Plant Cell Rep 25:274-80. 2006
    Factors affecting microspore embryogenesis of cow cockle (Saponaria vaccaria) were evaluated including donor plant growing conditions, genotype, bud size, density, medium composition, and culture conditions...
  98. ncbi Exposure of tilapia pituitary cells to saponins: insight into their mechanism of action
    Berta Levavi-Sivan
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Israel
    Comp Biochem Physiol C Toxicol Pharmacol 140:79-86. 2005
    Cell permeation and durable effects of triterpenoidal saponin preparations from soybean (SbS), Quillaja saponaria Molina (QsS) and Gypsophila paniculata (GypS), were studied...
  99. ncbi Differences in the in vitro susceptibility of mono-eukaryotic cultures of Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis sp. to natural organic compounds
    Elvira Grabensteiner
    Department for Farm Animals and Herd Management, Clinic for Avian, Reptile and Fish Medicine, University of Veterinary Medicine Vienna, Veterinarplatz 1, 1210 Vienna, Austria
    Parasitol Res 101:193-9. 2007
    ..this study, carvacrol, Cassia oil, an essential oil (EO) mixture containing thyme and rosemary EO and a Quillaja saponaria saponin were examined using in vitro assays for antiprotozoal and antibacterial activity testing established ..
  100. ncbi Induction of cell death by saponin and antigen delivery
    Ching An Wu
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Pharm Res 21:271-7. 2004
    ..The objective of this study was to investigate the apoptotic and necrotic effects induced by saponin in ELA mouse lymphoma cells, expected to be a possible mechanism of the cytotoxic T-lymphocyte (CTL) effect elicited by the ISCOM...
  101. doi Advances in saponin-based adjuvants
    Hong Xiang Sun
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Kaixuan Road 268, Hangzhou 310029, PR China
    Vaccine 27:1787-96. 2009
    ..widely used saponin-based adjuvants are Quil A and its derivatives QS-21, isolated from the bark of Quillaja saponaria Molina, which have been evaluated in numerous clinical trials...

Research Grants9

  1. Antibody-mediated Gene Therapy for the Treatment of Cancer
    Tracy Daniels; Fiscal Year: 2009
    ..The first gene encodes the toxin saporin, a ribosomal inactivating protein that is derived from the plant Saponaria officinialis...
  2. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS; Fiscal Year: 2010
    ..The first gene encodes the toxin saporin, a ribosomal inactivating protein that is derived from the plant Saponaria officinialis...
  3. Regulation by Immune Response to Vaccine by Botanicals
    Philip Livingston; Fiscal Year: 2005
    ..are the QS-21 and GPI-0100 triterpenoid saponins derived from the bark of the South American tree Quillaja saponaria Molina...
  4. SAPONIN ADJUVANT BASED HIV-1 SUBUNIT VACCINES
    Mark Newman; Fiscal Year: 1992
    ..We have developed methods to purify saponins from Quillaja saponaria and have identified one, termed QS-21, that is a potent adjuvant...
  5. New Adjuvant Technologies for a Marburg Virus Vaccine
    Ashish Pathak; Fiscal Year: 2004
    ..Saponins, especially from Gypsophilla species, Saponaria officinalis, and Quillaja saponaria Molina, possess potent immunomodulating activity (both humoral and cell ..
  6. New Adjuvant Technologies for a Marburg Virus Vaccine
    Ashish Pathak; Fiscal Year: 2005
    ..Saponins, especially from Gypsophilla species, Saponaria officinalis, and Quillaja saponaria Molina, possess potent immunomodulating activity (both humoral and cell ..
  7. New Adjuvant Technologies for a Marburg Virus Vaccine
    Ashish Pathak; Fiscal Year: 2005
    ..Saponins, especially from Gypsophilla species, Saponaria officinalis, and Quillaja saponaria Molina, possess potent immunomodulating activity (both humoral and cell ..
  8. In Vivo Antiviral Activity of Saponins
    MICHAEL RONER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Natural, aqueous extracts of Quillaja Saponaria, the Chilean Soap Bark Tree, contain several physiologically active triterpenoid saponins that display strong antiviral activity...