saponaria

Summary

Summary: A plant species of the family CARYOPHYLLACEAE. It is a source of SAPONINS. The common name "Soapwort" is also used with VACCARIA. The common name of "Bouncing Bet" is occasionally used with VIOLA.

Top Publications

  1. ncbi Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N OW9
    Phytochem Anal 17:414-23. 2006
  2. pmc Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
    Dauenpen Meesapyodsuk
    Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N OW9
    Plant Physiol 143:959-69. 2007
  3. ncbi Saponaria officinalis karyology and karyotype by means of image analyzer and atomic force microscopy
    S Di Bucchianico
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Microsc Res Tech 71:730-6. 2008
  4. ncbi Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium
    J L Turner
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 80:1939-46. 2002
  5. ncbi [The hypolipidemic action of the complex emulgator-stabilizer on the basis of laminal and a water extract from roots of alien Saponaria officinalis L. in experiment on the rat]
    T P Iudina
    Vopr Pitan 77:76-9. 2008
  6. ncbi Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body
    Sang Woo Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Miz Medi Hospital, Seoul, Korea
    Arch Pharm Res 26:1042-6. 2003
  7. ncbi High efficiency Agrobacterium rhizogenes-mediated transformation of Saponaria vaccaria L. (Caryophyllaceae) using fluorescence selection
    Janice F Schmidt
    Plant Biotechnology Institute, 110 Gymnasium Place, S7N OW9 Saskatoon, SK, Canada
    Plant Cell Rep 26:1547-54. 2007
  8. ncbi Multidimensional profiling of components in complex mixtures of natural products for metabolic analysis, proof of concept: application to Quillaja saponins
    Johan Bankefors
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 878:471-6. 2010
  9. pmc Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A)
    L Barbieri
    Dipartimento di Patologia sperimentale dell Università degli Studi di Bologna Via San Giacomo 14, I 40126 Bologna, Italy
    Nucleic Acids Res 25:518-22. 1997
  10. ncbi Evaluation of antioxidant, antinociceptive, and anti-inflammatory activities of ethanol extracts from Aloe saponaria Haw
    Eun Ah Yoo
    Laboratory of Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
    Phytother Res 22:1389-95. 2008

Research Grants

  1. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
  2. New Adjuvant Technologies for a Marburg Virus Vaccine
    Ashish Pathak; Fiscal Year: 2005
  3. In Vivo Antiviral Activity of Saponins
    MICHAEL RONER; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. ncbi Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N OW9
    Phytochem Anal 17:414-23. 2006
    ..array and single quadrupole electrospray mass detection for analysis and profiling of bisdesmosidic saponins in Saponaria vaccaria seed was developed...
  2. pmc Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
    Dauenpen Meesapyodsuk
    Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N OW9
    Plant Physiol 143:959-69. 2007
    b>Saponaria vaccaria (Caryophyllaceae), a soapwort, known in western Canada as cowcockle, contains bioactive oleanane-type saponins similar to those found in soapbark tree (Quillaja saponaria; Rosaceae)...
  3. ncbi Saponaria officinalis karyology and karyotype by means of image analyzer and atomic force microscopy
    S Di Bucchianico
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Microsc Res Tech 71:730-6. 2008
    The aim of this work was to offer a contribution to the characterization of taxonomic entity of Saponaria officinalis (2n = 28; an herbaceous perennial species; saporin, a type 1 Ribosome Inactivating Protein, is present in leaves and ..
  4. ncbi Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium
    J L Turner
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 80:1939-46. 2002
    ..9 kg and 24 d of age) were used in a 28-d experiment to determine the effects of Quillaja saponaria extract (QS) on weanling pig growth performance and immune function in response to enteric disease challenge ..
  5. ncbi [The hypolipidemic action of the complex emulgator-stabilizer on the basis of laminal and a water extract from roots of alien Saponaria officinalis L. in experiment on the rat]
    T P Iudina
    Vopr Pitan 77:76-9. 2008
    ..action of the complex emulgator-stabilizer (CES) on the basis of a water extract from roots of strange (alien) Saponaria officinalis L and laminal in the ratio 1:1,5 has been made...
  6. ncbi Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body
    Sang Woo Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Miz Medi Hospital, Seoul, Korea
    Arch Pharm Res 26:1042-6. 2003
    This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new ..
  7. ncbi High efficiency Agrobacterium rhizogenes-mediated transformation of Saponaria vaccaria L. (Caryophyllaceae) using fluorescence selection
    Janice F Schmidt
    Plant Biotechnology Institute, 110 Gymnasium Place, S7N OW9 Saskatoon, SK, Canada
    Plant Cell Rep 26:1547-54. 2007
    ..efficient and convenient method for the Agrobacterium rhizogenes-dependent production of transformed roots of Saponaria vaccaria L. (Caryophyllaceae) is described. The parameters tested and optimized include S...
  8. ncbi Multidimensional profiling of components in complex mixtures of natural products for metabolic analysis, proof of concept: application to Quillaja saponins
    Johan Bankefors
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 878:471-6. 2010
    ..described procedure has proven useful to discern several hundreds of saponin components when applied to Quillaja saponaria Molina bark extracts...
  9. pmc Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A)
    L Barbieri
    Dipartimento di Patologia sperimentale dell Università degli Studi di Bologna Via San Giacomo 14, I 40126 Bologna, Italy
    Nucleic Acids Res 25:518-22. 1997
    ..Recently we have shown that the RIP from Saponaria officinalis have a much wider substrate specificity: they are actually polynucleotide:adenosine glycosidases...
  10. ncbi Evaluation of antioxidant, antinociceptive, and anti-inflammatory activities of ethanol extracts from Aloe saponaria Haw
    Eun Ah Yoo
    Laboratory of Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
    Phytother Res 22:1389-95. 2008
    ..b>saponaria Haw...
  11. pmc Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin
    F Poccia
    Department of Biology, University of Rome Tor Vergata, Italy
    Br J Cancer 66:427-32. 1992
    ..Moreover, the MoAb ML30 was coupled to Saporin 6, a ribosome-inactivating protein recovered from the seeds of Saponaria officinalis, to kill HSP-expressing cells with a specific immunotoxin...
  12. ncbi Antiulcer activity of Sapindus saponaria L. in the rat
    Adriana L Meyer Albiero
    Department of Pharmacy and Pharmacology, Universidade Estadual de Maringa, PR Avenida Colombo, 5790 CEP 87020 900, Maringa, PR, Brazil
    J Ethnopharmacol 82:41-4. 2002
    Extracts of leaves and fruits of Sapindus saponaria L. were orally administered to rats and the parameters of gastric secretion (volume, pH and acidity) were evaluated after pylorus ligature...
  13. ncbi Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 21:1136-42. 2006
    ..The present study was performed to explore the initial involvement of macrophages in the development of T-cell-mediated chronic colitis...
  14. ncbi Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA
    L Barbieri
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo, 14, I 40126, Bologna, Italy
    Biochim Biophys Acta 1480:258-66. 2000
    Saporin-L1 from the leaves of Saponaria officinalis belongs to a group of plant polynucleotide:adenosine glycosidases, known as ribosome-inactivating proteins due to their property of depurinating the major rRNA...
  15. ncbi New pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans
    Beata Sadowska
    Department of Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    J Med Microbiol 63:1076-86. 2014
    The antifungal activity of the saponin-rich fractions (SFs) from Medicago sativa (aerial parts and roots) and Saponaria officinalis (used as a well-known source of plant saponins) against Candida albicans reference and clinical strains, ..
  16. ncbi Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species
    Tábitha Dahmer Rocha
    Laboratório de Fitoquímica e Síntese Orgânica, Departamento de Produção de Matéria Prima, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Av Ipiranga 2752, 90610 000, Porto Alegre, Rio Grande do Sul, Brazil
    Parasitol Res 110:2551-6. 2012
    ..Saponins from Passiflora alata and Quillaja saponaria presented the best anti-T. vaginalis activity (MIC = 0.025%)...
  17. ncbi Impact of Quillaja saponaria saponins on grapevine ecosystem organisms
    Marc J C Fischer
    Univ Strasbourg, Inst Natl Recherche Agron, Métab Second Vigne, Unit Mixte Recherche Santé Vigne and Qual Vins, Colmar, France
    Antonie Van Leeuwenhoek 100:197-206. 2011
    ..fermentation population were incubated on synthetic media supplemented with variable concentrations of Quillaja saponaria saponins. Saponins induced reduction in the growth of B. cinerea and showed nematicide effects on X. index...
  18. ncbi A trypsin inhibitor from Sapindus saponaria L. seeds: purification, characterization, and activity towards pest insect digestive enzyme
    Maria Ligia R Macedo
    Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Tecnologia de Alimentos e Saúde Pública, Centro de Ciencias Biologicas e da Saude, Universidade Federal do Mato Grosso do Sul UFMS, Cidade Universitária s n, Caixa Postal 549, Campo Grande, MS, CEP 79070 900, Brazil
    Protein J 30:9-19. 2011
    ..SSTI showed significant inhibitory activity against trypsin-like proteases present in the larval midgut on Anagasta kuehniella, Corcyra cephalonica, Diatreae saccharalis and Anticarsia gemmatalis...
  19. ncbi Feeding saponin-containing Yucca schidigera and Quillaja saponaria to decrease enteric methane production in dairy cows
    L Holtshausen
    Agriculture and Agri Food Canada, Lethbridge, Alberta, Canada T1J 4B1
    J Dairy Sci 92:2809-21. 2009
    ..was conducted in vitro to determine whether the addition of saponin-containing Yucca schidigera or Quillaja saponaria reduces methane production without impairing ruminal fermentation or fiber digestion...
  20. ncbi Interactions between saporin, a ribosome-inactivating protein, and DNA: a study by atomic force microscopy
    A Poma
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio, Coppito, L Aquila, Italy
    J Microsc 217:69-74. 2005
    ..force microscopy (AFM) has been used to study pGEM-4Z plasmid DNA binding to the saporin-SO6 (isoform from Saponaria officinalis seeds)...
  21. ncbi Effects of pressurized low polarity water extraction parameters on antioxidant properties and composition of cow cockle seed extracts
    Ozlem Güçlü-Ustündağ
    Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, 4200 Highway 97, Summerland, BC, Canada, V0H 1Z0
    Plant Foods Hum Nutr 64:32-8. 2009
    ..94). These results point to the potential of PLPW extraction as a method to modify the activity of biological materials for the production of customized extracts...
  22. ncbi The effect of AZT and chloroquine on the activities of ricin and a saporin-transferrin chimeric toxin
    A R Lizzi
    Department of Biomedical Sciences and Technologies, University of L Aquila, Via Vetoio snc, Loc Coppito, 67010 L Aquila, Italy
    Biochem Pharmacol 70:560-9. 2005
    ..a chimeric toxin (TS) obtained by chemical linking of saporin (a ribosome inactivating protein from the plant Saponaria officinalis) and human transferrin, in the intoxication of the human chronic myeloid leukaemia cells (K562)...
  23. ncbi Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition
    Deepa Sikriwal
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Int J Biochem Cell Biol 40:2880-8. 2008
    ..Saporin-6, expressed in the seeds of Saponaria officinalis plant, is a type I RIP comprising of a single polypeptide chain...
  24. ncbi The effects of Yucca schidigera and Quillaja saponaria on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in streptozotocin-induced diabetic rats
    A Fatih Fidan
    Department of Biochemistry, Faculty of Veterinary Medicine, Afyonkarahisar Kocatepe University, 03200 Afyonkarahisar, Turkey
    J Diabetes Complications 22:348-56. 2008
    The aim of this study was to examine the effects of Yucca schidigera, Quillaja saponaria, and a mixture of both plants on streptozotocin-induced diabetic rats. Animals were allocated into five groups with 10 rats each...
  25. ncbi Specific interaction between tetrandrine and Quillaja saponins in promoting permeabilization of plasma membrane in human leukemic HL-60 cells
    Y M Leung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Biochim Biophys Acta 1325:318-28. 1997
    ..Exposure of the cells for 5 min to saponins from Quillaja saponaria (QS, 30 microg/ml), surfactants well known to permeabilize the plasma membrane by complexing with cholesterol, ..
  26. ncbi Revision of some Thecaphora species (Ustilaginomycotina) on Caryophyllaceae
    Kálmán Vánky
    Herbarium Ustilaginales Vánky HUV, Gabriel Biel Str 5, D 72076 Tubingen, Germany
    Mycol Res 111:1207-19. 2007
    ..lat. from several caryophyllacean host plants belonging to the genera Cerastium, Dianthus, Petrorhagia, Saponaria, Silene, and Stellaria were studied by means of both LM, SEM, and molecular phylogenetic analyses using ITS and ..
  27. ncbi Saponins show high entomotoxicity by cell membrane permeation in Lepidoptera
    Ellen De Geyter
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Belgium
    Pest Manag Sci 68:1199-205. 2012
    ..In addition, the entomotoxic action of Q. saponaria saponin with primary midgut cell cultures and larval stages of the cotton leafworm Spodoptera littoralis was ..
  28. ncbi Phenolic profiles of nectar and honey of Quillaja saponaria Mol. (Quillajaceae) as potential chemical markers
    Gloria Montenegro
    Departamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 46:177-82. 2013
    Quillaja saponaria Mol. (Quillajaceae) is one of the most important melliferous species in Chile, mainly as a source of monofloral honey. Honey made by A...
  29. pmc Antimicrobial activity, growth inhibition of human tumour cell lines, and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts
    Khaled N Rashed
    Pharmacognosy Department, National Research Centre, Dokki, Giza 12311, Egypt
    Biomed Res Int 2013:659183. 2013
    The hydromethanolic extract of Sapindus saponaria L...
  30. ncbi ISCOMs: an adjuvant with multiple functions
    A Sjolander
    Immunology Department, CSL Limited, Parkville, Melbourne, Australia
    J Leukoc Biol 64:713-23. 1998
    ..about 40 nm that are built up by cholesterol, lipid, immunogen, and saponins from the bark of the tree Quillaia saponaria Molina...
  31. ncbi Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity
    P N Boyaka
    Department of Microbiology, University of Alabama, Medical Center, Birmingham, AL 35294, USA
    J Immunol 166:2283-90. 2001
    The highly purified saponin derivative, QS-21, from the Quillaja saponaria Molina tree has been proved to be safe for parenteral administration and represents a potential alternative to bacterial enterotoxin derivatives as a mucosal ..
  32. ncbi High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins
    Mayank Thakur
    Institute for Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Campus Virchow Klinikum, 13353 Berlin, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 955:1-9. 2014
    b>Saponaria officinalis L. (Caryophyllaceae), also known as fuller's herb or soapwort is a medicinal plant, which grows from Europe to Central Asia...
  33. ncbi Atomic model and micelle dynamics of QS-21 saponin
    Conrado Pedebos
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av Bento Goncalves 9500, CP 15005, Porto Alegre 91500 970, RS, Brazil
    Molecules 19:3744-60. 2014
    QS-21 is a saponin extracted from Quillaja saponaria, widely investigated as a vaccine immunoadjuvant...
  34. pmc Sexual dimorphism of staminate- and pistillate-phase flowers of Saponaria officinalis (bouncing bet) affects pollinator behavior and seed set
    Sandra L Davis
    University of Indianapolis, Department of Biology, Indianapolis, Indiana, United States of America
    PLoS ONE 9:e93615. 2014
    ..We examined staminate- and pistillate-phase flowers of protandrous Saponaria officinalis for dimorphism in floral traits and their effects on pollinator attraction and seed set...
  35. ncbi Unusual penetration of phospholipid mono- and bilayers by Quillaja bark saponin biosurfactant
    Kamil Wojciechowski
    Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00 664 Warsaw, Poland Electronic address
    Biochim Biophys Acta 1838:1931-40. 2014
    ..DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes...
  36. ncbi Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
    D J Marciani
    Galenica Pharmaceuticals, Inc, Frederick, MD 21701, USA
    Int Immunopharmacol 1:813-8. 2001
    ....
  37. ncbi In vivo delivery of bovine viral diahorrea virus, E2 protein using hollow mesoporous silica nanoparticles
    D Mahony
    Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072, Australia
    Nanoscale 6:6617-26. 2014
    ..250 μg HMSA was compared to immunisation with Opti-E2 (50 μg) together with the traditional adjuvant Quillaja saponaria Molina tree saponins (QuilA, 10 μg)...
  38. ncbi B-cell restricted saporin immunotoxins: activity against B-cell lines and chronic lymphocytic leukemia cells
    M Bregni
    Division of Medical Oncology, Istituto Nazionale Tumori, Milano, Italy
    Blood 73:753-62. 1989
    ..anti-B monoclonal antibodies to saporin, the major ribosome inactivating protein from the seeds of the plant Saponaria officinalis. HD37-SAP is directed against CD19, the broadest B cell-specific determinant...
  39. ncbi Accumulation of a bioactive triterpene saponin fraction of Quillaja brasiliensis leaves is associated with abiotic and biotic stresses
    Fernanda de Costa
    Department of Botany, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Plant Physiol Biochem 66:56-62. 2013
    ..a native species from Southern Brazil, show structural and functional similarities to those of Quillaja saponaria barks, which are currently used as adjuvants in vaccine formulations...
  40. ncbi Vaccination against Strongyloides venezuelensis with homologue antigens using new immunomodulators
    Johnny Vlaminck
    Laboratorio de Parasitologia, Facultad de Farmacia, CIETUS, Universidad de Salamanca, Avda Licenciado Méndez Nieto, 37007 Salamanca, Spain
    J Parasitol 96:643-7. 2010
    ..Moreover, we included saponins from Quillaja saponaria (Qs) and immunomodulatory substances, i.e...
  41. ncbi Effects of S. officinalis L. radix triterpene glycosides on innate immunity factors
    T A Kuznetsova
    Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia
    Bull Exp Biol Med 156:366-9. 2014
    The effects of triterpene glycosides (saponins) extracted from Saponaria officinalis L. radices, on the cellular and humoral innate immunity factors were studied...
  42. ncbi New triterpenoid saponins from the roots of Saponaria officinalis
    Barbara Moniuszko-Szajwaj
    Department of Biochemistry, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24 100 Pulawy, Poland
    Nat Prod Commun 8:1687-90. 2013
    Three new triterpenoid saponins (1-3), along with nine known saponins, were isolated from the roots of Saponaria officinalis L. Two of them: vaccaroside D (4) and dianchinenoside B (5) are known, but not previously reported for S...
  43. ncbi Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I)
    Stefan Böttger
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Str 2 4, 14195 Berlin, Germany
    Toxicon 73:144-50. 2013
    ..saponins for their non-synergistic, as well as their synergistic cytotoxicity with the RIP-I saporin from Saponaria officinalis L. (Caryophyllaceae)...
  44. ncbi Effects of quillaja saponin (Quillaja saponaria) on early embryonic zebrafish (Danio rerio) development
    Sherif M Hassan
    Poultry Science Department, College of Agriculture and Life Sciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Int J Toxicol 27:273-8. 2008
    ..Quillaja saponin, extracted from bark of the tree, Quillaja saponaria, is a common foaming agent used in foods and beverages...
  45. ncbi Immunomodulation of the response to excretory/secretory antigens of Fasciola hepatica by Anapsos in Balb/C mice and rat alveolar macrophages
    Julio López-Abán
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Salamanca, Avda Campo Charro s n, 37007 Salamanca, Spain
    J Parasitol 93:428-32. 2007
    ..In this work we assess the effect of Anapsos and ESFh and Quillaja saponaria extract (Qs) on BALB/c mice and rat alveolar macrophages...
  46. ncbi Role of Myzus persicae (Hemiptera: Aphididae) and its secondary hosts in plum pox virus propagation
    B Manachini
    Institute of Agricultural Entomology, University of Milan, via Celoria 2 1, 20133 Milan, Italy
    J Econ Entomol 100:1047-52. 2007
    ..The results indicate that Saponaria ocymoides L., Pisum sativum L., Trifolium repens L., Trifolium pratense L., Lepidium sativum L...
  47. ncbi The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities
    Shveta Bagga
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110067, India
    J Biol Chem 278:4813-20. 2003
    Saporin-6 produced by the plant Saponaria officinalis belongs to the family of single chain ribosome-inactivating proteins...
  48. ncbi Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine
    Dante J Marcian
    Galenica Pharmaceuticals, Inc, Birmingham, AL 35344, USA
    Int Immunopharmacol 2:1703-11. 2002
    ..Increasing the dose of DS-saponins tenfold resulted in a marginal increase in protection. These results show that degradation of Q. saponins during storage can have a deleterious effect on vaccines' efficacies...
  49. ncbi Enzymatic specificity of three ribosome-inactivating proteins against fungal ribosomes, and correlation with antifungal activity
    Sang Wook Park
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523, USA
    Planta 216:227-34. 2002
    ..saporin-S6 (from Saponaria officinalis L...
  50. ncbi Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum
    Ellen De Geyter
    Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Pest Manag Sci 68:164-9. 2012
    ..Four saponins were selected: two triterpene saponins, Q. saponaria saponins and aescin, and two steroidal saponins, digitonin and diosgenin...
  51. ncbi QS-21 structure/function studies: effect of acylation on adjuvant activity
    Gui Liu
    Antigenics Inc, 175 Crossing Boulevard, Framingham, MA 01702 4473, USA
    Vaccine 20:2808-15. 2002
    QS-21 is a natural saponin adjuvant derived from the tree Quillaja saponaria Molina. Previous studies over a limited dose range suggested the acylation is critical to adjuvant activity...
  52. ncbi Effects of Sapindus saponaria fruits on ruminal fermentation and duodenal nitrogen flow of sheep fed a tropical grass diet with and without legume
    A Abreu
    Department of Animal Production, National University of Colombia, Bogota, Colombia
    J Anim Sci 82:1392-400. 2004
    ..6% CP, DM basis) in a 3:1 ratio (DM basis). In addition, 0 or 8 g of DM of Sapindus saponaria fruits (12.0% crude saponins, DM basis) per kilogram of metabolic BW was administered intraruminally...
  53. ncbi Application of Quillaja saponaria extracts as oral adjuvants for plant-made vaccines
    Dwayne D Kirk
    Arizona State University, School of Life Sciences, Mail Code 4501, Tempe, Arizona 85287 4501, USA
    Expert Opin Biol Ther 4:947-58. 2004
    Extracts from the Quillaja saponaria tree are known to provide immune potentiating responses and, hence, can be useful as adjuvants...
  54. ncbi Surface shear rheology of saponin adsorption layers
    Konstantin Golemanov
    Department of Chemical Engineering, Faculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria
    Langmuir 28:12071-84. 2012
    ..Langmuir 2011, 27, 12486-12498), we showed that the triterpenoid saponins extracted from Quillaja saponaria plant (Quillaja saponins) formed adsorption layers with unusually high surface dilatational elasticity, 280 ± ..
  55. ncbi Differences in X-ray absorption due to cadmium treatment in Saponaria officinalis leaves
    Lucia Reale
    Universita di L Aquila, Dipartimento di Fisica and INFM, INFN LNGS, 67010, Coppito L Aquila, Italy
    Microsc Res Tech 64:21-9. 2004
    A method for detecting cadmium uptake in leaves of Saponaria officinalis doped with a solution of cadmium acetate is described...
  56. ncbi Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis
    Bernadete Pereira da Silva
    Laboratório de Química de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, P O Box 68045, CEP 21944 970 Rio de Janeiro, Brazil
    Vaccine 23:1061-71. 2005
    ..shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina)...
  57. ncbi Vaccination of mice and sheep with Fh12 FABP from Fasciola hepatica using the new adjuvant/immunomodulator system ADAD
    A R Martinez-Fernandez
    Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense, Pza Ramón y Cajal s n, 28040 Madrid, Spain
    Vet Parasitol 126:287-98. 2004
    ..The first injection contains a micelle in which two components are included, saponin from Quillaja saponaria (Qs) and/or Anapsos (A) a Polypodium leucotomos hydroalcoholic extract, both emulsified in a non-mineral oil (..
  58. ncbi Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
    Sylvia Arrau
    Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
    J Ethnopharmacol 133:164-7. 2011
    Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine.
  59. ncbi [Membranotropic effect of some triterpene glycosides possessing immunostimulating properties]
    I A Lee
    Biofizika 53:462-9. 2008
    ..holotoxin A1 and cucumarioside A2-2, respectively) were studied in comparison with plant saponins from Quillaja saponaria, known as hemolytic, adjuvant, and structure-forming components of immunostimulating complexes...
  60. pmc Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria
    Edilson Damke
    Department of Clinical Analysis and Biomedicine, Division of Clinical Cytology, State University of Maringa, Maringa, Paraná 4860, Brazil
    BMC Complement Altern Med 13:196. 2013
    Sapindus saponaria is used traditionally for curing ulcers, external wounds and inflammations. The spermicidal and anti-Trichomonas activity of S. saponaria and its effect on Lactobacillus acidophilus were evaluated.
  61. pmc The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme
    Carla J S Barber
    National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada
    J Biol Chem 288:12500-10. 2013
    Caryophyllaceae-type cyclic peptides (CPs) of 5-12 proteinogenic amino acids occur in 10 plant families. In Saponaria vaccaria (Caryophyllaceae), they have been shown to be formed from linear peptide precursors derived from ribosomal ..
  62. ncbi Micellar aggregates of saponins from Chenopodium quinoa: characterization by dynamic light scattering and transmission electron microscopy
    S G Verza
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Pharmazie 67:288-92. 2012
    ..Under experimental conditions similar to those reported for the preparation of Quillaja saponaria ISCOM matrices, tubular and ring-like micelles arose from FQ70:CHOL:PC and FQ90:CHOL:PC formulations, ..
  63. pmc Synthesis and structure verification of the vaccine adjuvant QS-7-Api. Synthetic access to homogeneous Quillaja saponaria immunostimulants
    Kai Deng
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 130:5860-1. 2008
    QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bark of Quillaja saponaria. It is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccine ..
  64. ncbi Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation
    M Cecilia Sampedro
    Departamento de Química Biológica CIQUIBIC, Facultad Ciencias Quimicas, Universidad Nacional de Cordoba, Cuidad Universitaria, C5000GYA Córdoba 5016, Argentina
    Int Immunopharmacol 4:411-8. 2004
    In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines...
  65. ncbi Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein from Saponaria officinalis
    C Savino
    Department of Biochemical Sciences and CNR, Centre for Molecular Biology, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Acta Crystallogr D Biol Crystallogr 54:636-8. 1998
    ..53 and c = 119. 67 A, and diffract to 2.0 A resolution on a rotating-anode X-ray source. The asymmetric unit contains one molecule, corresponding to a volume of the asymmetric unit per unit mass (Vm) of 2.38 A3 Da-1...
  66. ncbi The unusual stability of saporin, a candidate for the synthesis of immunotoxins
    S Santanché
    Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli, Universita di Roma La Sapienza, Italy
    Biochem Biophys Res Commun 234:129-32. 1997
    Saporin, a monomeric protein extracted from the seeds of Saponaria officinalis, is an enzyme capable of specific depurination of the eukaryotic ribosomes...
  67. ncbi A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia
    Kathleen Cathcart
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 103:1037-42. 2004
    ..phase 2 trial, 14 patients with CML in chronic phase were vaccinated with 6 fusion peptides mixed with Quillaja saponaria (QS-21). No significant toxic effects were observed...
  68. pmc Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)
    F Stirpe
    Biochem J 216:617-25. 1983
    ..to those already known [Barbieri & Stirpe (1982) Cancer Surveys 1, 489-520] were purified from the seeds of Saponaria officinalis (two proteins), of Agrostemma githago (three proteins), and of Asparagus officinalis (three proteins)..
  69. ncbi Intramolecular interchain reactions in bidesmosidic glycosides, a new insight into carbohydrate rearrangements induced by electrospray ionisation
    Fabrizio Dal Piaz
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    Rapid Commun Mass Spectrom 21:286-96. 2007
    ..components of widely used herbal drugs and pharmaceutical preparations; ginseng, Tribulus terrestris, Quillaja saponaria, and Digitalis ssp. are just a few examples...
  70. pmc Effects of saponins against clinical E. coli strains and eukaryotic cell line
    Michał Arabski
    Department of Microbiology, Institute of Biology, Jan Kochanowski University in Kielce, Kielce, Poland
    J Biomed Biotechnol 2012:286216. 2012
    ..In this study, the effects of saponins from Quillaja saponaria were analyzed against prokaryotic and eukaryotic cells. Multidrug-resistant clinical E...
  71. ncbi The use of commercial saponin from Quillaja saponaria bark as a natural larvicidal agent against Aedes aegypti and Culex pipiens
    D Pelah
    The Institutes for Applied Research, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Ethnopharmacol 81:407-9. 2002
    The larvicidal activity of commercial bark saponin extract (Sigma) from Quillaja saponaria was studied on 3rd-4th instar larvae of Aedes aegypti and Culex pipiens (vectors for dengue fever and Western Nile virus, respectively)...
  72. ncbi Effect of dietary saponins from Quillaja saponaria L. on fatty acid composition and cholesterol content in muscle Longissimus dorsi of lambs
    D M R Brogna
    1University of Catania, Dipartimento di Scienze delle Produzioni Agrarie e Alimentari, Via Valdisavoia 5, 95123, Catania, Italy
    Animal 5:1124-30. 2011
    The purpose of this study was to evaluate the effects of increasing levels of saponins from Quillaja saponaria on fatty acid (FA) composition and cholesterol content in muscle Longissimus dorsi of lambs...
  73. ncbi Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria
    Marcos L da Silva
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, UNAERP, Ribeirao Preto SP, Brazil
    Pharm Biol 50:366-75. 2012
    Sapindus saponaria L. (Sapindaceae) bark, root, and fruits are used as sedatives and to treat gastric ulcer and also demonstrate diuretic and expectorant effects.
  74. ncbi Diversity of foliar endophytic fungi from the medicinal plant Sapindus saponaria L. and their localization by scanning electron microscopy
    Adriana Garcia
    Department of Cell Biology and Genetics, Universidade Estadual de Maringa, Brasil
    Biol Res 45:139-48. 2012
    ..In folk medicine, the bark, roots and fruits of Sapindus saponaria is used to produce substances with anxiolytic, astringent, diuretic and expectorant properties, as well as ..
  75. ncbi An immunotoxin containing a rat IgM monoclonal antibody (Campath 1) and saporin 6: effect on T lymphocytes and hemopoietic cells
    P L Tazzari
    Istituto di Ematologia L and A Seragnoli, Bologna, Italy
    Cancer Immunol Immunother 26:231-6. 1988
    ..We used saporin 6 purified from Saponaria officinalis seeds, which was conjugated with the rat IgM monoclonal antibody Campath 1 specific for mature T and ..
  76. ncbi Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice
    Mayank Thakur
    Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Mol Oncol 7:475-83. 2013
    ..1 μg Sap3-EGF per treatment. A more than 90% reduction (p < 0.05) in the average tumor volume was observed by this combined therapy...
  77. ncbi Electrospray ionization ion-trap multiple-stage mass spectrometry of Quillaja saponins
    Johan Bankefors
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Mass Spectrom 46:658-65. 2011
    Fifteen identified C-18 fatty acyl-containing saponin structures from Quillaja saponaria Molina have been investigated by electrospray ionization ion-trap multiple-stage mass spectrometry (ESI-IT-MS(n)) in positive ion mode...
  78. ncbi Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines
    Ellen De Geyter
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    J Insect Physiol 58:18-23. 2012
    ..In continuation, it was of interest that (4) a trypan blue assay with Q. saponaria saponin confirmed the cell membrane permeation effect leading to cell toxicity with a median lethal ..
  79. ncbi Antiproliferative activity of Saponaria vaccaria constituents and related compounds
    J John Balsevich
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada
    Fitoterapia 83:170-81. 2012
    Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth ..
  80. ncbi Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease
    Ulrich Bienzle
    Institute of Tropical Medicine, Charite, Humboldt University, Spandauer Damm 130, 14050 Berlin, Germany
    Hepatology 38:811-9. 2003
    ..hepatitis B s antigen formulated with the new adjuvants 3-deacylated monophosphoryl lipid A (MPL) and Quillaja saponaria (QS21) (group I/vaccine A: 20 microg HBsAg, 50 microg MPL, 50 microg QS21; group II/vaccine B: 100 microg HBsAg, ..
  81. ncbi Liquid-chromatographic profiling of Saponinum album (Merck)
    A Weng
    Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charite Universitatsmedizin, Berlin, Germany
    Pharmazie 66:744-6. 2011
    ..that Saponinum album (Merck) dramatically enhances the toxicity of the N-glycosylase saporin from the seeds of Saponaria officinalis L. as well as the toxicity of a saporin based anti-tumor toxin...
  82. ncbi Composition of epiphytic bacterial communities differs on petals and leaves
    R R Junker
    Department of Animal Ecology and Tropical Biology, University of Wurzburg, Biozentrum, Wurzburg, Germany
    Plant Biol (Stuttg) 13:918-24. 2011
    ..We identified bacteria isolated from the surface of petals and leaves of two plant species, Saponaria officinalis (Caryophyllaceae) and Lotus corniculatus (Fabaceae)...
  83. pmc In vivo activity of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida species
    Edilson Damke
    Department of Clinical Analysis and Biomedicine, State University of Maringa, Parana, Brazil
    BMC Complement Altern Med 11:35. 2011
    Study of in vivo antifungal activity of the hydroalcoholic extract (HE) and n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida spp.
  84. pmc Characterization of in vivo anti-rotavirus activities of saponin extracts from Quillaja saponaria Molina
    Ka Ian Tam
    The University of Texas Arlington, Department of Biology, Arlington, TX 76019, USA
    Antiviral Res 90:231-41. 2011
    ..We believe that Quillaja extracts have promise as antivirals to reduce rotavirus infection and the severity of the disease in humans...
  85. ncbi Surface rheology of saponin adsorption layers
    R Stanimirova
    Department of Chemical Engineering, Faculty of Chemistry, Sofia University, 1 J Bourchier Avenue, 1164 Sofia, Bulgaria
    Langmuir 27:12486-98. 2011
    Extracts of the Quillaja saponaria tree contain natural surfactant molecules called saponins that very efficiently stabilize foams and emulsions. Therefore, such extracts are widely used in several technologies...
  86. ncbi The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors
    Janet A Condie
    Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK S7NOW9, Canada
    Plant J 67:682-90. 2011
    ..A collection of expressed sequence tags from developing seeds of Saponaria vaccaria was investigated for information about CP biosynthesis...
  87. pmc Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
    Govind Ragupathi
    Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Expert Rev Vaccines 10:463-70. 2011
    ..immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria)...
  88. pmc Immunotoxins and other conjugates containing saporin-s6 for cancer therapy
    Letizia Polito
    Department of Experimental Pathology, Alma Mater Studiorum University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Toxins (Basel) 3:697-720. 2011
    ..Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L...
  89. ncbi Use of meristem tip culture to eliminate carnation latent virus from carnation plants
    Manisha Mangal
    Department of Biotechnology, Dr Y S Parmar University of Horticulture and Forestry, Nauni, Solan 173 230, India
    Indian J Exp Biol 40:119-22. 2002
    ..amaranticolor, Dianthus barbatus and Saponaria vaccaria. Murashige and Skoog'smedium (MS) supplemented with NAA (1.0 microM) and Kn (20...
  90. ncbi Isolation and quantification of Quillaja saponaria Molina saponins and lipids in iscom-matrix and iscoms
    S Behboudi
    Swedish University of Agricultural Sciences, Department of Veterinary Microbiology, Uppsala
    Vaccine 13:1690-6. 1995
    ..The procedures described should also be useful to adequately define constituents in prospective vaccines...
  91. pmc Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata
    A M Di Massimo
    Menarini Ricerche SpA, Department of Biotechnology, Pomezia, Rome, Italy
    Br J Cancer 75:822-8. 1997
    ..linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria pyramidata respectively...
  92. ncbi QS-21 and QS-7: purified saponin adjuvants
    C R Kensil
    Aquila Biopharmaceuticals, Inc, Worcester, MA, USA
    Dev Biol Stand 92:41-7. 1998
    QS-21 and QS-7 are two adjuvant-active saponins that can be obtained in high purity from Quillaja saponaria Molina extracts...
  93. ncbi The plant ribosome inactivating protein saporin induces micronucleus formation in peripheral human lymphocytes in vitro
    A Poma
    Department of Basic and Applied Biology, Faculty of Sciences, University of L Aquila, Italy
    Toxicol Lett 105:67-73. 1999
    ..In this work we analyzed the genotoxic effects of saporin, purified from root cultures of Saponaria officinalis, by evaluating micronucleus formation and by the quantitative determination of cytosolic histone-..
  94. ncbi Preparation and characterisation of quillaja saponin with less heterogeneity than Quil-A
    S Kamstrup
    Danish Veterinary Institute for Virus Research, Lindholm, DK 4771, Kalvehave, Denmark
    Vaccine 18:2244-9. 2000
    ..One such type of adjuvant is saponin derived from the bark of Quillaja saponaria Molina, a tree of the rose family...
  95. ncbi Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity
    D J Marciani
    Galenica Pharmaceuticals, Inc, Frederick, MD 21701, USA
    Vaccine 18:3141-51. 2000
    Aldehyde-containing triterpene saponins have adjuvant properties, but only those from Quillaja saponaria Molina stimulate the production of cytotoxic T lymphocytes (CTL) against exogenous antigens...
  96. ncbi Stimulatory effect of some plant extracts used in homeopathy on the phagocytosis induced chemiluminescence of polymorphonuclear leukocytes
    D O Crocnan
    Department of Biochemistry, University of Medicine and Pharmacy Bucharest, Romania
    Rocz Akad Med Bialymst 45:246-54. 2000
    ..The high stimulatory action was noticed when extracts from Uvae Ursi and Saponaria were tested, as the classical effect exerted by zymosan was exceeded...
  97. ncbi Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73
    Emilio C Campos
    Ophthalmology Unit, University of Bologna, School of Medicine, Bologna, Italy
    Curr Eye Res 24:58-65. 2002
    ....
  98. ncbi Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, University of California at Los Angeles, Los Angeles, CA 90095 1782, USA
    Mol Cancer Ther 6:2995-3008. 2007
    ..of a conjugate composed of anti-hTfR IgG3-Av and biotinylated saporin 6 (b-SO6), a toxin derived from the plant Saponaria officinalis that inhibits protein synthesis...
  99. ncbi Solid-phase extraction NMR studies of chromatographic fractions of saponins from Quillaja saponaria
    Nils T Nyberg
    Department of Chemistry, Swedish University of Agricultural Sciences, Sweden
    Anal Chem 75:268-74. 2003
    The saponin mixture QH-B from the tree Quillaja saponaria var. Molina was fractionated by RP-HPLC in several steps...
  100. ncbi Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives
    Maité Rodríguez-Díaz
    Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
    J Pharm Pharmacol 63:718-24. 2011
    Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol...
  101. ncbi Alum-type adjuvant effect of non-haemolytic saponins purified from Ilex and Passiflora spp
    F Silveira
    Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Desarrollo Biotecnológico Departamento de Química Orgánica, Facultad de Medicina Química, Instituto de Higiene, Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay
    Phytother Res 25:1783-8. 2011
    ..Mice were immunized twice with TT formulated with pure saponins 1-5, or with a mixture of saponins from Quillaja saponaria, aluminum hydroxide gel or saline, which were used as controls...

Research Grants3

  1. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..The first gene encodes the toxin saporin, a ribosomal inactivating protein that is derived from the plant Saponaria officinialis...
  2. New Adjuvant Technologies for a Marburg Virus Vaccine
    Ashish Pathak; Fiscal Year: 2005
    ..Saponins, especially from Gypsophilla species, Saponaria officinalis, and Quillaja saponaria Molina, possess potent immunomodulating activity (both humoral and cell ..
  3. In Vivo Antiviral Activity of Saponins
    MICHAEL RONER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Natural, aqueous extracts of Quillaja Saponaria, the Chilean Soap Bark Tree, contain several physiologically active triterpenoid saponins that display strong antiviral activity...