humulus

Summary

Summary: A plant genus in the CANNABACEAE family. Best known for the buds of Humulus lupulus L. used in BEER.

Top Publications

  1. ncbi Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.)
    Jelle De Keukeleire
    Department of Plant Genetics and Breeding, Agricultural Research Centre, Caritasstraat 21, B 9090 Melle, Belgium
    J Agric Food Chem 51:4436-41. 2003
  2. doi Pharmacognostic and pharmacological profile of Humulus lupulus L
    Paola Zanoli
    Department of Biomedical Sciences, National InterUniversity Consortium for the Study of Natural Active Principles, University of Modena, Reggio Emilia, 41100 Modena, Italy
    J Ethnopharmacol 116:383-96. 2008
  3. doi High-throughput genotyping of hop (Humulus lupulus L.) utilising diversity arrays technology (DArT)
    E L Howard
    School of Plant Science, University of Tasmania, Hobart, TAS, Australia
    Theor Appl Genet 122:1265-80. 2011
  4. pmc EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol
    Jana Nagel
    National Research Council Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N 0W9
    Plant Cell 20:186-200. 2008
  5. pmc Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells
    D Deeb
    Department of Surgery, Henry Ford Health System, Surgical Research 4D, One Ford Place, Detroit, MI 48202, USA
    Anticancer Res 30:3333-9. 2010
  6. ncbi Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus
    Susanne Vogel
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    J Nat Prod 71:1237-41. 2008
  7. ncbi Treating primary insomnia - the efficacy of valerian and hops
    Shanah Salter
    Aust Fam Physician 39:433-7. 2010
  8. ncbi HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotes
    Jaroslav Matousek
    Biology Centre of the ASCR, v v i Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Agric Food Chem 55:7767-76. 2007
  9. doi Species delimitation under the general lineage concept: an empirical example using wild North American hops (Cannabaceae: Humulus lupulus)
    Patrick A Reeves
    United States Department of Agriculture, Agricultural Research Service, National Center for Genetic Resources Preservation, 1111 South Mason Street, Fort Collins, CO 80521, USA
    Syst Biol 60:45-59. 2011
  10. ncbi A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder
    U Koetter
    Max Zeller Sohne AG, CH 8590 Romanshorn, Switzerland
    Phytother Res 21:847-51. 2007

Research Grants

  1. Potential sedative mechanism for Humulus lupulus L.
    CASSIA OVERK; Fiscal Year: 2006
  2. MECHANISMS OF ACTION IN MENOPAUSE
    JUDY BOLTON; Fiscal Year: 2005
  3. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2012
  4. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2010
  5. Potential sedative mechanism for Humulus lupulus L.
    CASSIA OVERK; Fiscal Year: 2005
  6. Botanical Dietary Supplements for Women's Health (P50 A*
    Norman Farnsworth; Fiscal Year: 2006
  7. Botanical Dietary Supplements for Women's Health (P50 A*
    Norman Farnsworth; Fiscal Year: 2005
  8. BOTANICAL DIETARY SUPPLEMENTS FOR WOMEN'S HEALTH
    Norman Farnsworth; Fiscal Year: 2007
  9. BOTANICAL DIETARY SUPPLEMENTS FOR WOMEN'S HEALTH
    Norman Farnsworth; Fiscal Year: 2009
  10. Botanical Dietary Supplements for Women's Health
    Norman R Farnsworth; Fiscal Year: 2010

Detail Information

Publications191 found, 100 shown here

  1. ncbi Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.)
    Jelle De Keukeleire
    Department of Plant Genetics and Breeding, Agricultural Research Centre, Caritasstraat 21, B 9090 Melle, Belgium
    J Agric Food Chem 51:4436-41. 2003
    Important secondary metabolites, present in hops (Humulus lupulus L...
  2. doi Pharmacognostic and pharmacological profile of Humulus lupulus L
    Paola Zanoli
    Department of Biomedical Sciences, National InterUniversity Consortium for the Study of Natural Active Principles, University of Modena, Reggio Emilia, 41100 Modena, Italy
    J Ethnopharmacol 116:383-96. 2008
    The present review describes the morphological, phytochemical and ethnopharmacological aspects of Humulus lupulus L...
  3. doi High-throughput genotyping of hop (Humulus lupulus L.) utilising diversity arrays technology (DArT)
    E L Howard
    School of Plant Science, University of Tasmania, Hobart, TAS, Australia
    Theor Appl Genet 122:1265-80. 2011
    Implementation of molecular methods in hop (Humulus lupulus L.) breeding is dependent on the availability of sizeable numbers of polymorphic markers and a comprehensive understanding of genetic variation...
  4. pmc EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol
    Jana Nagel
    National Research Council Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N 0W9
    Plant Cell 20:186-200. 2008
    The glandular trichomes (lupulin glands) of hop (Humulus lupulus) synthesize essential oils and terpenophenolic resins, including the bioactive prenylflavonoid xanthohumol...
  5. pmc Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells
    D Deeb
    Department of Surgery, Henry Ford Health System, Surgical Research 4D, One Ford Place, Detroit, MI 48202, USA
    Anticancer Res 30:3333-9. 2010
    ..These studies provide a rationale for clinical evaluation of XN for the treatment of hormone-refractory metastatic prostate cancer...
  6. ncbi Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus
    Susanne Vogel
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    J Nat Prod 71:1237-41. 2008
    The minor hop ( Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized...
  7. ncbi Treating primary insomnia - the efficacy of valerian and hops
    Shanah Salter
    Aust Fam Physician 39:433-7. 2010
    ..To evaluate the efficacy of valerian and hops in the treatment of primary insomnia...
  8. ncbi HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotes
    Jaroslav Matousek
    Biology Centre of the ASCR, v v i Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Agric Food Chem 55:7767-76. 2007
    ..Southern blot analyses indicated that HlMyb3 is a unique gene, which was detected in various Humulus lupulus cultivars, but not in Humulus japonicus...
  9. doi Species delimitation under the general lineage concept: an empirical example using wild North American hops (Cannabaceae: Humulus lupulus)
    Patrick A Reeves
    United States Department of Agriculture, Agricultural Research Service, National Center for Genetic Resources Preservation, 1111 South Mason Street, Fort Collins, CO 80521, USA
    Syst Biol 60:45-59. 2011
    ..We have examined five different species criteria to ask whether the three taxonomic varieties of Humulus lupulus (hops) native to North America are distinct lineages...
  10. ncbi A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder
    U Koetter
    Max Zeller Sohne AG, CH 8590 Romanshorn, Switzerland
    Phytother Res 21:847-51. 2007
    ..The result underlined the plausibility for adding hops extract to the valerian extract...
  11. ncbi Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
    Jan F Stevens
    Department of Chemistry and the Linus Pauling Institute, Oregon State University, 117 Weniger Hall, Corvallis, OR 97331, USA
    Phytochemistry 65:1317-30. 2004
    ..The prenylflavonoid pathway is a possible target for breeding or biotechnological modification of hops with the aim of increasing xanthohumol levels for beer brewing and 8-prenylnaringenin levels for pharmaceutical production...
  12. ncbi Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
    ..We report anticarcinogenic properties of Xanthohumol (XN), a prenylated chalcone from hop (Humulus Iupulus L...
  13. doi Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L
    A Gatica-Arias
    Plant Breeding and Biotechnology, Institute for Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, Stuttgart, Germany
    Plant Cell Rep 31:111-9. 2012
    ....
  14. ncbi Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase
    Birgit M Dietz
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 18:1296-305. 2005
    The female parts of hops (Humulus lupulus L.) show estrogenic effects as well as cancer chemopreventive potential...
  15. ncbi Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds
    Marjan Van Cleemput
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Gent, Belgium
    J Nat Prod 72:1220-30. 2009
    Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo...
  16. pmc Combinatorial analysis of lupulin gland transcription factors from R2R3Myb, bHLH and WDR families indicates a complex regulation of chs_H1 genes essential for prenylflavonoid biosynthesis in hop (Humulus Lupulus L.)
    Jaroslav Matousek
    Biology Centre ASCR vvi, Institute of Plant Molecular Biology, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    BMC Plant Biol 12:27. 2012
    ....
  17. doi HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops
    Yusuke Tsurumaru
    Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Japan
    Biochem Biophys Res Commun 417:393-8. 2012
    Female flowers of hop (Humulus lupulus L...
  18. ncbi Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin
    S Milligan
    Endocrinology and Reproduction Research Group, School of Biomedical Sciences, King s College, Guy s Campus, London SE1 1UL, UK
    Reproduction 123:235-42. 2002
    ..When the compound was given to ovariectomized mice in their drinking water, oestrogenic stimulation of the vaginal epithelium required concentrations of 100 mug ml(-1) (about 500-fold greater than can be found in any beer)...
  19. ncbi The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism
    R Schellenberg
    Institut für Ganzheitliche Medizin und Wissenschaft, Hüttenberg, Germany
    Planta Med 70:594-7. 2004
    ..In conclusion, the valerian/hop extract acts via a central adenosine mechanism which is possibly the reason for its sleep-inducing and -maintaining activity...
  20. doi Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma
    Marjan Van Cleemput
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Gent, Belgium
    Mol Nutr Food Res 53:1143-55. 2009
    Hop (Humulus lupulus L.) is an essential ingredient of beer, where it provides the typical bitter taste, but is also applied in traditional folk medicine for sedative and antibacterial purposes...
  21. pmc Disposition of hop prenylflavonoids in human breast tissue
    Selin Bolca
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Belgium
    Mol Nutr Food Res 54:S284-94. 2010
    ..6+/-118.8 fmol/g, p=0.009) and glandular (241.6+/-93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue...
  22. pmc Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis
    Guodong Wang
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 106:9914-9. 2009
    Myrcene, which accounts for 30-50% of the essential oil in hop (Humulus lupulus L.) trichomes, derives from geranyl diphosphate (GPP), the common precursor of monoterpenes...
  23. ncbi Cloning and molecular analysis of the regulatory factor HlMyb1 in hop (Humulus lupulus L.) and the potential of hop to produce bioactive prenylated flavonoids
    Jaroslav Matousek
    Institute of Plant Molecular Biology AS CR, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Agric Food Chem 53:4793-8. 2005
    ....
  24. ncbi Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells
    Yan Pang
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Mol Nutr Food Res 51:872-9. 2007
    Used in the brewing of beer, hops (Humulus lupulus L...
  25. ncbi The antimycobacterial components of hops (Humulus lupulus) and their dereplication
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK
    Phytother Res 18:774-6. 2004
    Bioassay-guided fractionation of a hexane extract of strobile hops (Humulus lupulus) was undertaken to isolate and characterize the antimycobacterial constituents using the fast-growing mycobacterial species Mycobacterium fortuitum...
  26. ncbi In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors
    E A Abourashed
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Phytomedicine 11:633-8. 2004
    ..Binding affinities could be demonstrated at some of the screened melatonin (ML1 and ML2) and serotonin (5-HT4e, 5-HT6 and 5-HT7) receptor subtypes...
  27. doi Molecular cytogenetic mapping of Humulus lupulus sex chromosomes
    M G Divashuk
    Center for Molecular Biotechnology, Russian State Agrarian University MTAA, Moscow, Russia
    Cytogenet Genome Res 134:213-9. 2011
    ..A good example of a plant with heteromorphic sex chromosomes is hop (Humulus lupulus). The genotypes carrying XX or XY chromosomes correspond to female and male plants, respectively...
  28. ncbi Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer
    Paulo J Magalhães
    REQUIMTE, Departamento de Química da Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169 007 Porto, Portugal
    Nat Prod Commun 4:591-610. 2009
    ..This paper reviews recent and important data with respect to the health benefits or biological activities of xanthohumol and beer. In addition, an overview of the chemistry and biotechnological aspects of xanthohumol is presented...
  29. pmc DNA sequence and expression variation of hop (Humulus lupulus) valerophenone synthase (VPS), a key gene in bitter acid biosynthesis
    Consuelo B Castro
    School of Plant Science, University of Tasmania, Private Bag 55, Hobart, Tasmania, 7001, Australia
    Ann Bot 102:265-73. 2008
    The hop plant (Humulus lupulus) is a source of many secondary metabolites, with bitter acids essential in the beer brewing industry and others having potential applications for human health...
  30. ncbi The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets
    Beata Olas
    Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
    Platelets 22:345-52. 2011
    The plant Humulus lupulus is known as the raw material of the brewing industry. Hop cones, rich in polyphenolic compounds and acyl phloroglucides, are widely used to preserve beer and to give it a characteristic aroma and flavor...
  31. ncbi Comparative chemical attributes of native North American hop, Humulus lupulus var. lupuloides E. Small
    Richard Hampton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Phytochemistry 61:855-62. 2002
    The genetic diversity of 159 representative genotypes of native hop (Humulus lupulus var. lupuloides E...
  32. ncbi Sedating effects of Humulus lupulus L. extracts
    H Schiller
    Phytomedicine 13:535-41. 2006
    It was the aim of the study to check ethanolic and CO2 extracts from Humulus lupulus for sedating activity...
  33. ncbi A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
    Arne Heyerick
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium
    Maturitas 54:164-75. 2006
    To examine the efficacy of a hop extract enriched in 8-prenylnaringenin (8-PN, the phytoestrogen in hops, Humulus lupulus L.) on relief of menopausal discomforts.
  34. ncbi Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Gent University UGent, Coupure Links 653, Gent, Belgium
    J Agric Food Chem 53:6281-8. 2005
    ....
  35. ncbi Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol
    Javor Kac
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Phytomedicine 15:216-20. 2008
    ..These results indicate that xanthohumol is a very promising potential protective agent against genotoxicity of food borne carcinogens, which warrants further investigation...
  36. doi Evaluation of genetic variability of wild hops (Humulus lupulus L.) in Canada and the Caucasus region by chemical and molecular methods
    Josef Patzak
    Hop Research Institute Co Ltd, Kadanská 2525, 438 46 Zatec, Czech Republic
    Genome 53:545-57. 2010
    Wild hops (Humulus lupulus L.) are potential new germplasms to expand the variability of genetic resources for hop breeding...
  37. ncbi Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death
    L Delmulle
    Ghent University Ugent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B 9000 Ghent, Belgium
    Phytother Res 22:197-203. 2008
    ..X), isoxanthohumol (IX), 8-prenylnaringenin (8PN) and 6-prenylnaringenin (6PN), prenylflavonoids from hop (Humulus lupulus L...
  38. pmc The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties
    L R Chadwick
    UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Phytomedicine 13:119-31. 2006
    ..through 2003, only two clinical trials were identified that were designed to evaluate the effect of hops (Humulus lupulus L.) on symptoms related to menopause...
  39. ncbi Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors
    Hitoshi Aoshima
    Department of Physics, Biology and Informatics, Faculty of Science, Yamaguchi University, Yoshida, Yamaguchi 753 8512, Japan
    J Agric Food Chem 54:2514-9. 2006
    ..Furthermore, the pentane extract of the beer, hop (Humulus lupulus L.) oil, and myrcenol potentiated the GABA(A) receptor response elicited by GABA...
  40. ncbi Estrogens and congeners from spent hops (Humulus lupulus)
    Lucas R Chadwick
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 67:2024-32. 2004
    Estrogenicity-directed fractionation of a methanol extract of the strobiles of Humulus lupulus that had been extracted previously with supercritical CO(2), known as "spent hops", led to the isolation and identification of 22 ..
  41. doi Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), in ischemic stroke of rats
    Ting Lin Yen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 60:1937-44. 2012
    Xanthohumol is the principal prenylated flavonoid in hops (Humulus lupulus L.), an ingredient of beer. Xanthohumol was found to be a potent chemopreventive agent; however, no data are available concerning its neuroprotective effects...
  42. doi Phytochemical and morphological characterization of hop (Humulus lupulus L.) cones over five developmental stages using high performance liquid chromatography coupled to time-of-flight mass spectrometry, ultrahigh performance liquid chromatography photodi
    Adam R Kavalier
    Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, Bronx, New York 10468, United States
    J Agric Food Chem 59:4783-93. 2011
    Hop (Humulus lupulus L.) inflorescences, commonly known as "hop cones", are prized for their terpenophenolic contents, used in beer production and, more recently, in biomedical applications...
  43. doi Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells
    Rita Negrão
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Cell Biochem 111:1270-9. 2010
    ..Furthermore, these results may provide clues for developing useful therapeutic agents against inflammation- and angiogenesis-associated pathologies...
  44. ncbi Assessment of genetic variation and differentiation of hop genotypes by microsatellite and AFLP markers
    J Jakse
    Centre for Plant Biotechnology and Breeding, Biotechnical Faculty, University of Ljubljana, Slovenia
    Genome 44:773-82. 2001
    ..The results of microsatellite and AFLP analysis are discussed from the point of view of the applicability of the two marker systems for different aspects of germplasm evaluation...
  45. pmc Terpene biosynthesis in glandular trichomes of hop
    Guodong Wang
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73410, USA
    Plant Physiol 148:1254-66. 2008
    Hop (Humulus lupulus L...
  46. doi In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris
    Naoto Yamaguchi
    Betal, LLC, 5185 MacArthur Blvd, NW, Suite 300, Washington, DC 20016, USA
    Phytomedicine 16:369-76. 2009
    Seven naturally derived components from hop plant (Humulus lupulus L.) extracts were tested for evaluation of biological activities affecting acne vulgaris...
  47. doi Varietal characterization of hop (Humulus lupulus L.) by GC-MS analysis of hop cone extracts
    Robert A Shellie
    Australian Centre for Research on Separation Science, University of Tasmania, Hobart, Australia
    J Sep Sci 32:3720-5. 2009
    An approach is described for use in the varietal characterization of hop (Humulus lupulus L.) varieties. The study focuses on commercial hop varieties and was timed to coincide with the 2008 commercial hop harvest in Tasmania, Australia...
  48. ncbi The antimicrobial effects of hops (Humulus lupulus L.) on ruminal hyper ammonia-producing bacteria
    M D Flythe
    USDA, Agricultural Research Service, Forage Animal Production Research Unit, Lexington, KY, USA
    Lett Appl Microbiol 48:712-7. 2009
    To assess the antimicrobial effects of hops (Humulus lupulus L.) on hyper ammonia producing-bacteria (HAB), which catabolize amino acids and peptides in the bovine rumen.
  49. pmc Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (Humulus lupulus)
    Shawn M Clark
    National Research Council of Canada, 110 Gymnasium Place, Saskatoon, SK, S7N 0W9, Canada
    BMC Plant Biol 13:12. 2013
    Bitter acids (e.g. humulone) are prenylated polyketides synthesized in lupulin glands of the hop plant (Humulus lupulus) which are important contributors to the bitter flavour and stability of beer...
  50. ncbi Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.)
    Jian Guo
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, IL 60612 7231, USA
    Drug Metab Dispos 34:1152-9. 2006
    The female flowers of hops (Humulus lupulus L.) are used in the brewing of beer and are under investigation for use in dietary supplements for the management of menopausal symptoms in women...
  51. ncbi Genetic mapping of hop (Humulus lupulus L.) applied to the detection of QTLs for alpha-acid content
    Andreja Cerenak
    Slovenian Institute of Hop Research and Brewing, Zalec
    Genome 49:485-94. 2006
    The map locations and effects of quantitative trait loci (QTLs) were estimated for alpha-acid content in hop (Humulus lupulus L...
  52. ncbi Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer
    Barbara Vanhoecke
    Department of Gynecology, Ghent University Hospital, Gent, Belgium
    Int J Cancer 117:889-95. 2005
    The female inflorescences of the hop plant (Humulus lupulus L.) are essential during brewing to add taste and flavor to beer and to stabilize beer foam...
  53. ncbi Regeneration and Agrobacterium-mediated transformation of hop (Humulus lupulus L.)
    C Horlemann
    Department of Plant Breeding and Biotechnology, Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70599 Stuttgart, Germany
    Plant Cell Rep 22:210-7. 2003
    An efficient procedure for direct organogenesis and regeneration of hop (Humulus lupulus L.) was established. For the first time Agrobacterium-mediated genetic transformation of hop (cv. "Tettnanger") was achieved...
  54. ncbi A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts
    R Erkkola
    Department of Obstetrics and Gynecology, Turku University Central Hospital, 20521 Turku, Finland
    Phytomedicine 17:389-96. 2010
    ..To examine the efficacy of a hop extract (standardized at 100mug 8-prenylnaringenin per day) for relief of menopausal discomforts...
  55. ncbi Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission
    P Zanoli
    Department of Biomedical Sciences, Section of Pharmacology, National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Ethnopharmacol 109:87-92. 2007
    b>Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop beta-acids on central nervous system function...
  56. ncbi Molecular phylogeny of wild hops, Humulus lupulus L
    A Murakami
    Kirin Brewery Co, Ltd, Research Laboratory for Brewing, 1 17 1 Namamugi Tsurumi ku, Yokohama 230 8628, Japan
    Heredity (Edinb) 97:66-74. 2006
    ..diversity and the geographical distribution of haplotypes, to investigate the evolution and phylogeny of hops, Humulus lupulus...
  57. ncbi Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement
    N G Coldham
    Department of Risk Research, Veterinary Laboratories Agency, Addlestone, KT15 3NB, Surrey, UK
    Food Chem Toxicol 39:1211-24. 2001
    ..These preliminary findings suggest that the dietary supplement is unlikely to produce oestrogenic effects in vivo at the level of the uterus; supporting evidence is still required to demonstrate efficacy...
  58. ncbi Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
    Qian Wang
    Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Antiviral Res 64:189-94. 2004
    Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study...
  59. pmc Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)
    Cassia R Overk
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, M C 781, University of Illinois, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Agric Food Chem 53:6246-53. 2005
    ..The strobiles of Humulus lupulusL...
  60. pmc Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulus L.)
    Guo qing He
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
    J Zhejiang Univ Sci B 6:999-1004. 2005
    ..8 mg/g). HPLC-MS analysis of the extracts indicated that flavonoids obtained were xanthohumol, the principal prenylflavonoid in hops...
  61. ncbi Hop (Humulus lupulus L.) proanthocyanidins characterized by mass spectrometry, acid catalysis, and gel permeation chromatography
    Alan W Taylor
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    J Agric Food Chem 51:4101-10. 2003
    Proanthocyanidins extracted from hops (Humulus lupulus L. cv. Willamette) were subjected to Sephadex LH-20 column chromatography using a step gradient of methanol, water, and acetone...
  62. ncbi Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance
    Hiroaki Yajima
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa 236 0004, Japan
    J Biol Chem 279:33456-62. 2004
    ..1 and 6.4%, respectively, versus week 0). These results suggest that isohumulones can improve insulin sensitivity in high fat diet-fed mice with insulin resistance and in patients with type 2 diabetes...
  63. pmc In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.)
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612 7231, USA
    Pharm Res 23:864-72. 2006
    The absorption potential and metabolism of 8-prenylnaringenin (8-PN) from hops (Humulus lupulus L.) were investigated. 8-PN is a potent estrogen with the potential to be used for the relief of menopausal symptoms in women.
  64. ncbi horC confers beer-spoilage ability on hop-sensitive Lactobacillus brevis ABBC45cc
    K Iijima
    Analytical Technology Laboratory, Asahi Breweries, Ltd, Ibaraki, Japan
    J Appl Microbiol 100:1282-8. 2006
    ..To determine whether horC confers beer-spoilage ability and to evaluate the validity of horC as a trans-species genetic marker for differentiating the beer-spoilage ability of lactic acid bacteria (LAB)...
  65. ncbi Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice
    Veronika Butterweck
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, PO Box 100494, FL 32610, USA
    J Pharm Pharmacol 59:549-52. 2007
    Hops (Humulus lupulus, Cannabinaceae) has been used in traditional European medicine as a mild sedative for the treatment of anxiety, nervousness, and insomnia...
  66. doi Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes
    Elvira Lupinacci
    Division of Human Nutrition, Wageningen University, Wageningen, The Nethelands
    J Agric Food Chem 57:7274-81. 2009
    ..The hop plant (Humulus lupulus L.) has been described to possess both anti-inflammatory and antidiabetic effects...
  67. doi Vegetative propagation and its possible role as a genetic bottleneck in the shaping of the apple fruit crinkle viroid populations in apple and hop plants
    Teruo Sano
    Department of Plant Pathology, Faculty of Agriculture and Life Science, Gene Research Center, Hirosaki University, Hirosaki, 036 8561, Japan
    Virus Genes 37:298-303. 2008
    ..In this scenario, a genetic bottleneck caused by vegetative propagation played an important role in the shaping of viroid populations in a cultivated crop...
  68. ncbi Cloning and molecular analysis of HlbZip1 and HlbZip2 transcription factors putatively involved in the regulation of the lupulin metabolome in hop (Humulus lupulus L.)
    Jaroslav Matousek
    Biology Centre of the ASCR, vvi Institute of Plant Molecular Biology, Branisovska 31, 37005 Ceske Budejovice, Czech Republic
    J Agric Food Chem 58:902-12. 2010
    Hop (Humulus lupulus L.), the essential source of beer flavor is of interest from a medicinal perspective in view of its high content in health-beneficial terpenophenolics including prenylflavonoids...
  69. ncbi Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.)
    Jelle De Keukeleire
    Institute for Agricultural and Fisheries Research, Unit Plant, Research Domain Genetics and Breeding, Caritasstraat 21, 9090 Melle, Belgium
    J Agric Food Chem 55:61-6. 2007
    ..WC proved to be a rich source of bioactive chalcones, particularly desmethylxanthohumol...
  70. pmc Experimental transmission of pospiviroid populations to weed species characteristic of potato and hop fields
    J Matousek
    Institut für Physikalische Biologie, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    J Virol 81:11891-9. 2007
    ..retroflexus and V. argensis exhibited similarity or identity to the superlethal AS1 viroid variant. All HSVd clones from G. ciliata corresponded to a HSVdg variant, which is strongly pathogenic for European hops...
  71. ncbi The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    Sam Possemiers
    Unit on Ecology and Physiology of the Digestive Tract UEPSD, National Institute for Agricultural Research INRA, F 78352 Jouy en Josas Cedex, France
    J Nutr 136:1862-7. 2006
    ..6417, P < 0.01). These data show that intestinal conversion of IX upon moderate beer consumption can lead to 8-PN exposure values that might fall within the range of human biological activity...
  72. ncbi Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine
    Sam Possemiers
    Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B 9000 Gent, Belgium
    J Nutr 138:1310-6. 2008
    ..In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats...
  73. ncbi Sequence analysis of a "true" chalcone synthase (chs_H1) oligofamily from hop (Humulus lupulus L.) and PAP1 activation of chs_H1 in heterologous systems
    Jaroslav Matousek
    Biological Centre AS CR, Institute of Plant Molecular Biology, Branisovska 31, 37005 Ceske Budejovice, Czech Republic
    J Agric Food Chem 54:7606-15. 2006
    ..codetermine the biosynthesis of prenylated chalcones known to be valuable medicinal compounds present in hop (Humulus lupulus L.)...
  74. ncbi Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines
    L Delmulle
    Ghent University Ugent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, and Ghent University Hospital, Department of Endocrinology, Belgium
    Phytomedicine 13:732-4. 2006
    Chalcones xanthohumol (X) and desmethylxanthohumol (DMX), present in hops (Humulus lupulus L...
  75. ncbi Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL 60612 7231, USA
    Drug Metab Dispos 32:272-9. 2004
    ..An unusual hydroxy quinone product formed by ipso hydroxylation of the B ring of 8-prenylnaringenin was also detected. This product was probably an intermediate for the B ring cleavage product, 8-prenylchromone...
  76. ncbi Enzymatic reactions by five chalcone synthase homologs from hop (Humulus lupulus L.)
    Yukio Okada
    Bioresources Research and Development Laboratories, Sapporo Breweries, Ltd, Gunma, Japan
    Biosci Biotechnol Biochem 68:1142-5. 2004
    ..Narigenin-chalcone production by VPS was much lower than by CHS_H1. Therefore, it is highly possible that flavonoid depends mainly on CHS_H1, while bitter acid biosynthesis depends mainly on VPS and CHS_H1...
  77. pmc Organogenic nodule development in hop (Humulus lupulus L.): transcript and metabolic responses
    Ana M Fortes
    ICAT, FCUL, University of Lisbon, Campo Grande, 1749 016 Lisbon, Portugal
    BMC Genomics 9:445. 2008
    Hop (Humulus lupulus L.) is an economically important plant forming organogenic nodules which can be used for genetic transformation and micropropagation...
  78. doi Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines
    Yi Chien Ho
    Department of Bioengineering, Tatung University, Taipei, Taiwan
    Phytother Res 22:1465-8. 2008
    ..It was shown for the first time that xanthohumol from hops effectively inhibits proliferation of human hepatocellular carcinoma cells in vitro...
  79. doi Genetic and epigenetic stability of cryopreserved and cold-stored hops (Humulus lupulus L.)
    Elena L Peredo
    Department of Plant Physiology, Universidad de Oviedo, Catedrático Rodrigo Uría s n, 33071 Oviedo, Spain
    Cryobiology 57:234-41. 2008
    Conventional cold storage and cryopreservation methods for hops (Humulus lupulus L.) are available but, to our knowledge, the genetic and epigenetic stability of the recovered plants have not been tested...
  80. ncbi Expression of allene oxide cyclase and accumulation of jasmonates during organogenic nodule formation from hop (Humulus lupulus var. Nugget) internodes
    Ana M Fortes
    Laboratory of Molecular Biology and Plant Biotechnology, Ed ICAT, FCUL, Campo Grande, Lisboa, Portugal
    Plant Cell Physiol 46:1713-23. 2005
    ..3.99.6). A cDNA of AOC was isolated from Humulus lupulus var. Nugget...
  81. ncbi Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice
    Hajime Nozawa
    R and D Laboratory, Functional Food Division, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Biochem Biophys Res Commun 336:754-61. 2005
    ..From the present results, it is suggested that XN acts on FXR through a selective bile acid receptor modulator (SBARM) like guggulsterone or polyunsaturated fatty acids, which have previously been reported as SBARMs...
  82. ncbi Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.)
    Yuichi Sakano
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2439-46. 2004
    A cDNA encoding adenylate isopentenyltransferase (AIPT) was cloned and sequenced from cones of hop (Humulus lupulus L...
  83. ncbi Differential expression and cellular localization of ERKs during organogenic nodule formation from internodes of Humulus lupulus var. Nugget
    Marta Sousa Silva
    Laboratory of Plant Biotechnology ICAT, Campus of Science Faculty of Lisbon, Campo Grande, 1749 016 Lisboa, Portugal
    Eur J Cell Biol 83:425-33. 2004
    ..kinase 1 or 2 (ERK1/2) homologues (HLERK1/2) during the process of organogenic nodule formation in Humulus lupulus var...
  84. ncbi Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms
    Wilfried Dimpfel
    Justus Liebig University Giessen, c o NeuroCode AG, Sportparkstr 9, 35578 Wetzlar, Germany
    Eur J Med Res 13:200-4. 2008
    ..Thus, the present investigation has shown evidence that a valerian/hops fluid extract can be used successfully using a single administration...
  85. ncbi Cold storage and cryopreservation of hops (Humulus l.) shoot cultures through application of standard protocols
    Barbara M Reed
    U S Department of Agriculture, Agricultural Research Service, National Clonal Germplasm Repository, 33447 Peoria Road, Corvallis, OR 97333, USA
    Cryo Letters 24:389-96. 2003
    The USDA-ARS National Clonal Germplasm Repository (NCGR) stores the global diversity of Humulus for the US Plant Germplasm System as trellised plants in a field genebank...
  86. doi Broth and agar hop-gradient plates used to evaluate the beer-spoilage potential of Lactobacillus and Pediococcus isolates
    M Haakensen
    Department of Pathology and Laboratory Medicine, Room 2841 Royal University Hospital, 103 Hospital Drive, University of Saskatchewan, Saskatoon, SK Canada S7N 0W8
    Int J Food Microbiol 130:56-60. 2009
    ....
  87. ncbi Expression of lipoxygenase during organogenic nodule formation from hop internodes
    Ana Margarida Fortes
    Centro de Biotecnologia Vegetal, Faculdade de Ciencias, Universidade Lisboa, Lisboa, Portugal
    J Histochem Cytochem 52:227-41. 2004
    Study of lipoxygenase expression (LOX; EC 1.13.11.12) during organogenic nodule formation in hop (Humulus lupulus var...
  88. ncbi Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities
    Axel Schwekendiek
    Institute of Plant Breeding, Seed Science, and Population Genetics, Department of Plant Breeding and Biotechnology, University of Hohenheim, 70593 Stuttgart, Germany
    J Agric Food Chem 55:7002-9. 2007
    ..Hop (Humulus lupulus L.) plants of the Tettnang variety were transformed with a gene encoding for STS from grapevine...
  89. doi Efficient and stable transformation of hop (Humulus lupulus L.) var. Eroica by particle bombardment
    Dora Batista
    Unit of Molecular Biology and Plant Biotechnology, Institute of Applied Science and Technology ICAT, Science Faculty, Lisbon University, Campo Grande, 1749 016 Lisbon, Portugal
    Plant Cell Rep 27:1185-96. 2008
    To the best of our knowledge, this is the first accurate and reliable protocol for hop (Humulus lupulus L.) genetic transformation using particle bombardment...
  90. ncbi Construction of gene expression system in hop (Humulus lupulus) lupulin gland using valerophenone synthase promoter
    Yukio Okada
    Plant Bioengineering Research Laboratories, Sapporo Breweries Ltd, 37 1, Kizaki, Nitta, Gunma 370 0393, Japan
    J Plant Physiol 160:1101-8. 2003
    The promoter region of the valerophenone synthase (VPS) gene was isolated from hop (Humulus lupulus)...
  91. ncbi NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones
    Alfi Khatib
    Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Phytochem Anal 18:371-7. 2007
    ..Six iso-alpha-acids were isolated from a carbon dioxide extract of the cones of Humulus lupulus L. by centrifugal partition chromatography followed by separation through beta-cyclodextrin binding...
  92. ncbi Exploring the use of natural antimicrobial agents and pulsed electric fields to control spoilage bacteria during a beer production process
    M A Galvagno
    Laboratório de Microbiologia Industrial, Departamento de Ingenieria Quimica, Facultad de Ingenieria, Pabellón de Industrias, Universidad de Buenos Aires, Ciudad Universitaria 1428, Buenos Aires, Argentina
    Rev Argent Microbiol 39:170-6. 2007
    ..The results herein obtained suggest that the use of these antimicrobial compounds in isolation or in combination with PEF would be effective to control bacterial contamination during beer production and storage...
  93. ncbi Positive antibacterial co-action between hop (Humulus lupulus) constituents and selected antibiotics
    P Natarajan
    School of Natural Sciences, Fairleigh Dickinson University, Teaneck, NJ, USA
    Phytomedicine 15:194-201. 2008
    The research reported here deals with co-action of the hop (Humulus lupulus)-derived anti-bacterial compounds, lupulone and xanthohumol, with several antibiotics...
  94. pmc Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS
    Yongsoo Choi
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Comb Chem High Throughput Screen 11:1-6. 2008
    ..Immobilized ER was incubated with extracts of Trifolium pratense L. (red clover) or Humulus lupulus L. (hops)...
  95. doi New prenylchalcones from the hops of Humulus lupulus
    Wen Shu Wang
    College of Chemistry and Molecular Engineering, Peking University, Beijing, China
    J Asian Nat Prod Res 10:485-90. 2008
    ..4) were isolated and identified from the hops of Humulus lupulus L...
  96. ncbi Hop bract polyphenols reduced three-day dental plaque regrowth
    K Shinada
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Japan
    J Dent Res 86:848-51. 2007
    ..05). These findings suggested that HBP, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans...
  97. ncbi Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid
    Axel Brattström
    Max Zeller Sohne AG, Romanshorn, Switzerland
    Wien Med Wochenschr 157:367-70. 2007
    ..The control is closely related to endogenous melatonin secretion. Hops act in a similar way to melatonin. Therefore, the efficacy of a valerian and hops combination in sleep disorder can scientifically be explained...
  98. ncbi Hop polyphenols suppress production of water-insoluble glucan by Streptococcus mutans and dental plaque growth in vivo
    Ken Yaegaki
    School of Life Dentistry, Nippon Dental University, Tokyo, Japan
    J Clin Dent 19:74-8. 2008
    ..This study determined the effect of Hop polyphenols (HPP) on water-insoluble glucan (WIG), which is a major component of dental plaque along with microorganisms, and the effect of HPP-containing tablets on the growth of dental plaque...
  99. ncbi Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis
    Jeong Yeh Yang
    Department of Animal and Dairy Science, 444 Edgar L Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA 30602 2771, USA
    Apoptosis 12:1953-63. 2007
    ..Taken together, our data indicate that both XN and IXN inhibit differentiation of preadipocytes, and induce apoptosis in mature adipocytes, but XN is more potent...
  100. ncbi Total synthesis of xanthohumol
    Rahul S Khupse
    Center for Drug Design and Development, College of Pharmacy, The University of Toledo, Toledo, Ohio 43606 3390, USA
    J Nat Prod 70:1507-9. 2007
    ..A Claisen-Schmidt condensation was deployed to construct the chalcone scaffold followed by removal of MOM protecting groups under acidic conditions that were optimized to prevent concomitant cyclization to the flavone...
  101. ncbi Ability of prenylflavanones present in hops to induce apoptosis in a human Burkitt lymphoma cell line
    Reinhard A Diller
    Institute of Technology for Biogenic Resources, Technical University of Munich, Straubing, Germany
    Planta Med 73:755-61. 2007
    ..g., 8-prenylnaringenin (7) and 8-geranylnaringenin (10), which have been identified in hops (Humulus lupulus), and their synthetic variations 8-furanmethylnaringenin (8) and 8-cinnamylnaringenin (9)...

Research Grants40

  1. Potential sedative mechanism for Humulus lupulus L.
    CASSIA OVERK; Fiscal Year: 2006
    ..b>Humulus lupulus (hops) alone and in combination with Valerian officinalis L...
  2. MECHANISMS OF ACTION IN MENOPAUSE
    JUDY BOLTON; Fiscal Year: 2005
    ..Specifically, we are interested in botanicals with estrogenic activity such as hops (Humulus lupulus), kudzu (Pueraria lobata), and kwao keur (Pueraria mirifica)...
  3. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2012
    ..Xanthohumol (XN), the principal prenylflavonoid of hops (Humulus lupulus), modulates FXR and was shown to lower plasma triglycerides and glucose in a mouse model of MetS...
  4. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2010
    ..Xanthohumol (XN), the principal prenylflavonoid of hops (Humulus lupulus), modulates FXR and was shown to lower plasma triglycerides and glucose in a mouse model of MetS...
  5. Potential sedative mechanism for Humulus lupulus L.
    CASSIA OVERK; Fiscal Year: 2005
    ..b>Humulus lupulus (hops) alone and in combination with Valerian officinalis L...
  6. Botanical Dietary Supplements for Women's Health (P50 A*
    Norman Farnsworth; Fiscal Year: 2006
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  7. Botanical Dietary Supplements for Women's Health (P50 A*
    Norman Farnsworth; Fiscal Year: 2005
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  8. BOTANICAL DIETARY SUPPLEMENTS FOR WOMEN'S HEALTH
    Norman Farnsworth; Fiscal Year: 2007
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  9. BOTANICAL DIETARY SUPPLEMENTS FOR WOMEN'S HEALTH
    Norman Farnsworth; Fiscal Year: 2009
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  10. Botanical Dietary Supplements for Women's Health
    Norman R Farnsworth; Fiscal Year: 2010
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  11. BOTANICAL DIETARY SUPPLEMENTS FOR WOMEN'S HEALTH
    Norman Farnsworth; Fiscal Year: 2005
    ..Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle...
  12. Potential sedative mechanism for Humulus lupulus L.
    CASSIA OVERK; Fiscal Year: 2004
    ..b>Humulus lupulus (hops) alone and in combination with Valerian officinalis L...
  13. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2005
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  14. Novel Protein-Based Therapeutics for Nerve Agent Detoxification
    MATTHEW REDINBO; Fiscal Year: 2008
    ..It is clear that effective catalytic countermeasures are urgently needed to safely protect military personnel and civilian first-responders from attacks involving chemical weapons. ..
  15. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2008
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  16. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Stevens; Fiscal Year: 2009
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  17. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2009
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  18. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2003
    ..5. Assess the efficacy of drug activation and the ability to sensitize cells expressing mutant forms of rCE, hCE1 and hiCE to CPT-11. ..
  19. Improving CPT-11 Efficacy Using Structural and Chemical Biology
    MATTHEW REDINBO; Fiscal Year: 2009
    ....
  20. Improving CPT-11 Efficacy Using Structural and Chemical Biology
    MATTHEW REDINBO; Fiscal Year: 2010
    ....
  21. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Frederik Stevens; Fiscal Year: 2010
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  22. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2010
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  23. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2002
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  24. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2009
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  25. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2002
    ....
  26. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Stevens; Fiscal Year: 2008
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  27. Novel Protein-Based Therapeutics for Nerve Agent Detoxification
    MATTHEW REDINBO; Fiscal Year: 2007
    ..It is clear that effective catalytic countermeasures are urgently needed to safely protect military personnel and civilian first-responders from attacks involving chemical weapons. ..
  28. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2004
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  29. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2006
    ..5. Assess the efficacy of drug activation and the ability to sensitize cells expressing mutant forms of rCE, hCE1 and hiCE to CPT-11. ..
  30. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2004
    ....
  31. Hybrid triple quadrupole linear ion trap mass spectrometer
    Jan Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  32. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2006
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  33. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Stevens; Fiscal Year: 2006
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  34. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2003
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  35. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2007
    ..2- 2 Description, ..
  36. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2003
    ....
  37. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Stevens; Fiscal Year: 2007
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  38. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2001
    ....