alstonia

Summary

Summary: A plant genus of the family APOCYNACEAE. Members contain echitovenidine, echitamine, venenatine (an indole alkaloid), and anti-inflammatory triterpenoids

Top Publications

  1. ncbi New indole alkaloids from the bark of Alstonia scholaris
    Angela A Salim
    Institute for Molecular Bioscience and Department of Chemistry, The University of Queensland, Brisbane, QLD 4072, Australia
    J Nat Prod 67:1591-4. 2004
  2. ncbi Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract
    G Arunachalam
    ICMR Virus Unit Calcutta, I D and B G Hospital, Beliaghata, Kolkata, India
    Phytomedicine 9:632-5. 2002
  3. ncbi Alkaloids from Alstonia angustifolia
    Toh Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Phytochemistry 65:603-8. 2004
  4. ncbi A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract
    Debprasad Chattopadhyay
    ICMR Virus Unit, Infectious Diseases and Beliaghata General Hospital, Beliaghata, Kolkata 700010, India
    Contraception 71:372-8. 2005
  5. ncbi Some Nigerian plants of dermatologic importance
    Frances O A Ajose
    Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria
    Int J Dermatol 46:48-55. 2007
  6. pmc Insecticidal activity of the medicinal plant, Alstonia boonei De Wild, against Sesamia calamistis Hampson
    Osawe Nathaniel Oigiangbe
    Department of Zoology, Ambrose Alli University, Ekpoma, Edo State, Nigeria
    J Zhejiang Univ Sci B 8:752-5. 2007
  7. ncbi The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats
    Manjeshwar Shrinath Baliga
    Department of Radiobiology, Kasturba Medical College, Manipal 576104, Karnataka, India
    Toxicol Lett 151:317-26. 2004
  8. ncbi Evaluation of Alstonia scholaris leaves for broncho-vasodilatory activity
    Shabana Channa
    Department of Pharmacology and Therapeutics, Frontier Medical College, Abbottabad, Pakistan
    J Ethnopharmacol 97:469-76. 2005
  9. ncbi Effect of Alstonia scholaris bark extract on testicular function of Wistar rats
    R S Gupta
    Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Asian J Androl 4:175-8. 2002
  10. ncbi Indole alkaloids from the leaves of Philippine Alstonia scholaris
    Allan Patrick G Macabeo
    Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana St, Manila 1008, Philippines
    Phytochemistry 66:1158-62. 2005

Scientific Experts

Detail Information

Publications95

  1. ncbi New indole alkaloids from the bark of Alstonia scholaris
    Angela A Salim
    Institute for Molecular Bioscience and Department of Chemistry, The University of Queensland, Brisbane, QLD 4072, Australia
    J Nat Prod 67:1591-4. 2004
    ..N-oxide (5), akuammicine N-oxide (6), and N(b)-demethylalstogustine (7), were isolated from the trunk bark of Alstonia scholaris collected in Timor, Indonesia. The structures of all compounds were elucidated by spectroscopic methods...
  2. ncbi Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract
    G Arunachalam
    ICMR Virus Unit Calcutta, I D and B G Hospital, Beliaghata, Kolkata, India
    Phytomedicine 9:632-5. 2002
    Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o...
  3. ncbi Alkaloids from Alstonia angustifolia
    Toh Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Phytochemistry 65:603-8. 2004
    ..and 10-methoxycathafoline N(4)-oxide, in addition to 36 other known alkaloids, were obtained from the leaf extract of Alstonia angustifolia var. latifolia. The structures of the new alkaloids were determined using NMR and MS analysis.
  4. ncbi A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract
    Debprasad Chattopadhyay
    ICMR Virus Unit, Infectious Diseases and Beliaghata General Hospital, Beliaghata, Kolkata 700010, India
    Contraception 71:372-8. 2005
    The methanol extract (ME) and the n-butanol fractions of methanolic extract of Alstonia macrophylla Wall ex A. DC leaves were investigated on the forward motility (FM) of mammalian (goat and human) spermatozoa...
  5. ncbi Some Nigerian plants of dermatologic importance
    Frances O A Ajose
    Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria
    Int J Dermatol 46:48-55. 2007
    ..Nigerians still depend largely on crude herbal remedies or traditional medicine. They also use wild plants for cosmetics and perfumery. Some of these herbal remedies have been observed to be effective in certain skin diseases...
  6. pmc Insecticidal activity of the medicinal plant, Alstonia boonei De Wild, against Sesamia calamistis Hampson
    Osawe Nathaniel Oigiangbe
    Department of Zoology, Ambrose Alli University, Ekpoma, Edo State, Nigeria
    J Zhejiang Univ Sci B 8:752-5. 2007
    The bioactivity of the aqueous extracts of the leaf and stem bark of the medicinal plant, Alstonia boonei De Wild (Apocyanaceae), against the pink stalk borer, Sesamia calamistis Hampson (Lepidoptera: Noctuidae) was studied in a ..
  7. ncbi The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats
    Manjeshwar Shrinath Baliga
    Department of Radiobiology, Kasturba Medical College, Manipal 576104, Karnataka, India
    Toxicol Lett 151:317-26. 2004
    The acute and sub-acute toxic effects of various doses of hydroalcoholic extract of Alstonia scholaris (ASE) was studied in mice and rats. The acute toxicity in mice depended on the season of collection of plant...
  8. ncbi Evaluation of Alstonia scholaris leaves for broncho-vasodilatory activity
    Shabana Channa
    Department of Pharmacology and Therapeutics, Frontier Medical College, Abbottabad, Pakistan
    J Ethnopharmacol 97:469-76. 2005
    The present study demonstrates that the ethanol extract of Alstonia scholaris (Apocynaceae) leaves induced pronounced bronchodilatory activity in anaesthetized rats with the probable involvement of prostaglandins...
  9. ncbi Effect of Alstonia scholaris bark extract on testicular function of Wistar rats
    R S Gupta
    Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Asian J Androl 4:175-8. 2002
    To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.
  10. ncbi Indole alkaloids from the leaves of Philippine Alstonia scholaris
    Allan Patrick G Macabeo
    Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana St, Manila 1008, Philippines
    Phytochemistry 66:1158-62. 2005
    ..and N4-methyl angustilobine B (2), were isolated from the (pH 5) alkaloid extract of Philippine Alstonia scholaris leaves together with the known indole alkaloids 19,20-(E)-vallesamine (3), angustilobine B N4-oxide (4),..
  11. ncbi [Flavonoids in leaves of Alstonia scholaris]
    Tingting Hui
    School of Pharmacy, Yunnan College of Traditonal Chinese Medicine, Kunming 650200, China
    Zhongguo Zhong Yao Za Zhi 34:1111-3. 2009
    To investigate the flavonoids in leaves of Alstonia scholaris, an ethno-remedy of Dai People in Yunnan.
  12. doi Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris
    Fei Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
    Phytochemistry 70:650-4. 2009
    2,3-Secofernane triterpenoids, alstonic acids A (1) and B (2), were isolated from the leaves of Alstonia scholaris together with an indole alkaloid, N(1)-methoxymethyl picrinine (3)...
  13. doi A cage-monoterpene indole alkaloid from Alstonia scholaris
    Xiang Hai Cai
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Scienes, Kunming 650204, China
    Org Lett 10:577-80. 2008
    An unprecedented cage-like alkaloid, scholarisine A was isolated from the leaves of Alstonia scholaris and its structure determined on the basis of 1D and 2D NMR, FTIR, UV, and high-resolution mass spectroscopic data...
  14. ncbi Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna) in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, India
    Phytother Res 20:103-9. 2006
    The anticancer effect of various doses of an alkaloid fraction of Sapthaparna, Alstonia scholaris (ASERS), was studied in vitro in cultured human neoplastic cell lines (HeLa, HepG(2), HL60, KB and MCF-7) and in Ehrlich ascites carcinoma ..
  15. ncbi Protective effect of Alstonia scholaris against radiation-induced clastogenic and biochemical alterations in mice
    Swafiya Jahan
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    J Environ Pathol Toxicol Oncol 29:101-11. 2010
    We studied the radioprotective effect of Alstonia scholaris bark extract (ASE) on cytogenetic alterations in the form of chromosomal aberrations and micronuclei induction in bone marrow...
  16. doi Amelioration of radiation-induced hematological and biochemical alterations by Alstonia scholaris (a medicinal plant) extract
    Uma Gupta
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Integr Cancer Ther 7:155-61. 2008
    The radioprotective efficacy of a hydro-alcoholic extracted material from the bark of Alstonia scholaris (ASE) was studied in mice against radiation-induced hematological and biochemical alterations...
  17. ncbi Actinophyllic acid, a potent indole alkaloid inhibitor of the coupled enzyme assay carboxypeptidase u/hippuricase from the leaves of Alstonia actinophylla (Apocynaceae)
    Anthony R Carroll
    Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Australia 4111
    J Org Chem 70:1096-9. 2005
    Bioassay-guided fractionation of the aqueous extract of the leaves of Alstonia actinophylla with use of a coupled enzyme assay, CPU/hippuricase, to detect carboxypeptidase U inhibitors led to the isolation of a novel indole alkaloid, ..
  18. doi Pharmacological evaluation of Alstonia scholaris: anti-inflammatory and analgesic effects
    Jian Hua Shang
    Yunnan Institute of Medical Material, Kunming, PR China
    J Ethnopharmacol 129:174-81. 2010
    b>Alstonia scholaris (Apocynaceae) has been historically used in "dai" ethnopharmacy to treat chronic respiratory diseases...
  19. ncbi Antimicrobial activity of Alstonia macrophylla: a folklore of bay islands
    D Chattopadhyay
    ICMR Virus Unit, Calcutta Infectious Diseases and Beliaghata General Hospital Campus, GB 4 1st Floor, Beliaghata Main Road, Calcutta 700010, India
    J Ethnopharmacol 77:49-55. 2001
    The methanolic crude and methanol-aqueous extract of Alstonia macrophylla leaves and n-butanol part of the crude extract showed antimicrobial activity against various strains of Staphylococcus aureus, Staphylococcus saprophyticus, ..
  20. ncbi Screening of plant extracts for antiprotozoal and cytotoxic activities
    M d R Camacho
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Ethnopharmacol 89:185-91. 2003
    ..5 microg/ml against Leishmania donovani. Annona purpurea and Alstonia macrophylla had IC50 values below 10 microg/ml against Trypanosoma brucei brucei...
  21. doi A combination of alkaloids and triterpenes of Alstonia scholaris (Linn.) R. Br. leaves enhances immunomodulatory activity in C57BL/6 mice and induces apoptosis in the A549 cell line
    Liang Feng
    Key Laboratory of New Drug Delivery Systems of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, Jiangsu, China
    Molecules 18:13920-39. 2013
    ..to evaluate the induction of apoptosis and the immunomodulatory activities of alkaloids and triterpenes of Alstonia scholaris (Linn.) R. Br. leaves (ASL)...
  22. ncbi Photoactivated [3+2] addition of 6,7-seco-angustilobine B to fullerene [C60]
    Allan Patrick G Macabeo
    Organic Synthesis and Phytochemistry Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana, Manila 1015, Philippines
    Nat Prod Commun 7:743-5. 2012
    ..The reaction was carried out by photoinduced [3+2] cycloaddition of the Alstonia indole alkaloid, 6,7-seco-angustilobine B (2), to fullerene[C60] (3) under aerobic conditions...
  23. doi Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
    Azis Saifudin
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Nat Med 67:264-70. 2013
    ..Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus ..
  24. doi Monoterpenoid indole alkaloids from Alstonia rupestris with cytotoxic, anti-inflammatory and antifungal activities
    Wei Wang
    Department of Pharmacy, No 455 Hospital of People s Liberation Army, Shanghai 200052, China
    Molecules 18:7309-22. 2013
    Phytochemical investigation of the 70% EtOH extract of the leaves of Alstonia scholaris afforded seven new monoterpenoid indole alkaloids: scholarisins I-VII (1-7), and three known compounds: (3R,5S,7R,15R,16R,19E)-scholarisine F (8), 3-..
  25. doi Assessment of the antidiarrhoeal properties of the aqueous extract, the 80% methanol extract and its soluble fractions of the leaves of Alstonia congensis Engl. (Apocynaceae) in Wistar rats
    S Nsaka Lumpu
    Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa XI, Democratic Republique of Congo
    J Ethnopharmacol 142:620-6. 2012
    To evaluate the antidiarrhoeal properties of Alstonia congensis leaves claimed to be effective for the treatment of diarrhoea by traditional healers during our ethnopharmacological investigation conducted in Kinshasa, Democratic Republic ..
  26. ncbi Unusual nitrogenous derivatives from Alstonia
    Shin Jowl Tan
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Nat Prod Commun 7:739-42. 2012
    Five new nitrogenous compounds were isolated from the Malayan Alstonia angustifolia and their structures determined based on interpretation of spectroscopic data.
  27. doi Macroline-sarpagine and macroline-pleiocarpamine bisindole alkaloids from Alstonia angustifolia
    Shin Jowl Tan
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Phytochemistry 85:194-202. 2013
    ..to the macroline-sarpagine group, and five belonging to the macroline-pleiocarpamine group, were isolated from the stem-bark extracts of Alstonia angustifolia (Apocynacea). Their structures were established using NMR and MS analyses.
  28. doi Lumusidines A-D and villalstonidine F, macroline-macroline and macroline-pleiocarpamine bisindole alkaloids from Alstonia macrophylla
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Phytochemistry 87:148-56. 2013
    ..and one of the macroline-pleiocarpamine type, villalstonidine F, were isolated from the stem-bark extract of Alstonia macrophylla (Apocynaceae)...
  29. doi Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt
    Hesham I El-Askary
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
    Nat Prod Res 26:1755-8. 2012
    Ethanolic and aqueous extracts of the leaves and flowers of Alstonia scholaris were evaluated for their antioxidant activity by investigating their effect on blood glutathione levels in alloxan-induced diabetic rats...
  30. ncbi Therapeutic effects of various solvent fractions of Alstonia boonei (apocynaceae) stem bark on Plasmodium berghei-induced malaria
    J O Olanlokun
    Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria
    Afr J Med Med Sci 41:27-33. 2012
    ..boonei are lipophillic and further purification could enhance greater activity. Further work is required to isolate the bioactive compound for a promising antimalarial drug from the chloroform fraction...
  31. doi Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla
    Sarot Cheenpracha
    School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand
    J Nat Prod 76:723-6. 2013
    Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and ..
  32. ncbi Assessment of air pollution stress on some commonly grown tree species in industrial zone of Durgapur, West Bengal, India
    S Nayek
    Department of Environmental Science, The University of Burdwan, Golapbag, Burdwan, West Bengal 713 104, India
    J Environ Sci Eng 53:57-64. 2011
    ..87-238.53%) and proline content (123.47-284.91%). Of the studied tree species, Shorea robusta (9.78 +/- 0.095), Alstonia scholaris (8.76 +/- 0.084), Peltophorum pterocarpum (8.99 +/- 0.13) and Albizia lebbeck (7.71 +/- 0...
  33. doi Perhentidines A-C: macroline-macroline bisindoles from Alstonia and the absolute configuration of perhentinine and macralstonine
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 75:942-50. 2012
    ..alkaloids of the macroline-macroline type, perhentidines A-C (1-3), were isolated from the stem-bark extract of Alstonia macrophylla and Alstonia angustifolia...
  34. doi Synthesis of the core of actinophyllic acid using a transannular acyl radical cyclization
    Hisaaki Zaimoku
    School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Org Lett 14:1656-8. 2012
    ..A transannular acyl radical cyclization allowed us to obtain a key bicyclo[3.3.2] framework, and construction of a core of the target alkaloid has been accomplished by subsequent introduction of a C2 unit...
  35. pmc Botanicals to control soft rot bacteria of potato
    M M Rahman
    Department of Plant Pathology, Bangabadhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh
    ScientificWorldJournal 2012:796472. 2012
    ..cheerota (Swertia chiraita Ham.), chatim (Alstonia scholaris L.), mander (Erythrina variegata), bael (Aegle marmelos L...
  36. doi Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don
    Kanokwan Changwichit
    Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand
    Fitoterapia 82:798-804. 2011
    The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e...
  37. doi Ethnopharmacological survey of Annonaceae medicinal plants used to treat malaria in four areas of Cameroon
    Nole Tsabang
    Institute of Medical Research and Medicinal Plants Studies IMPM, Yaounde, Cameroon
    J Ethnopharmacol 139:171-80. 2012
    ..In some Cameroonian settings, in addition to the commonly used potions from plants like Alstonia boonei, Zanthoxylum macrophylla and Mangifera indica, other herbal species are being increasingly used to treat ..
  38. doi Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants
    Afolabi C Akinmoladun
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria
    J Med Food 13:444-51. 2010
    Methanolic extracts of 10 selected Nigerian medicinal plants-Psidium guajava, Alstonia boonei, Cassia alata, Newbouldia laevis, Spondias mombin, Globimetula cupulatum, Chromolaena odorata, Securidaca longepedunculata, Ocimum gratissimum, ..
  39. doi Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter
    Hiroko Arai
    Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 18:2152-8. 2010
    ..E-G (1-3) and a new ajmaline-type alkaloid, alstiphyllanine H (4) were isolated from the leaves of Alstonia macrophylla together with 16 related alkaloids (5-20)...
  40. ncbi Assessment of air pollution tolerance index of some trees in Moradabad city, India
    Anamika Tripathi
    Ecology Research Laboratory, Departmentof Botany, Hindu College, Moradabad 244 001, India
    J Environ Biol 30:545-50. 2009
    ..e. Ficus rumphii, Pongamia pinnata, Alstonia scholaris, Holoptelea integrifolia, Saraca indica, Pithecolobium dulcis, Cassia simea, Bauhinia variegata, ..
  41. doi Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India
    Sunil Kumar Singh
    Department of Zoology, DDU Gorakhpur University, Gorakhpur 273 009 UP, India
    J Appl Toxicol 30:1-7. 2010
    ..Common medicinal plants, i.e. Thevetia peruviana, Alstonia scholaris (Family; Apocynaceae), Euphorbia pulcherima and Euphorbia hirta (Family; Euphorbiaceae), have potent ..
  42. doi Monoterpenoid indole alkaloids from Alstonia yunnanensis
    Tao Feng
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People s Republic of China
    J Nat Prod 72:1836-41. 2009
    ..Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of the new alkaloids were established by means of extensive spectroscopic methods...
  43. doi Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from Alstonia macrophylla
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 74:2556-62. 2011
    Four new linearly fused bisindole alkaloids, lumutinines A-D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla...
  44. doi Mutagenic screening of some commonly used medicinal plants in Nigeria
    Alade Akintonwa
    Department of Pharmacology, College of Medicine, University of Lagos Nigeria, Lagos, Nigeria
    J Ethnopharmacol 125:461-70. 2009
    ..Plumbago zeylanica [Inabiri (Root)], Xylopia aethiopica [Erunje (Fruit)], Newbouldia laevis [Akoko (Leaf)], Alstonia boonei [Ahun (Bark)], Enantia chlorantha [Awopa (Bark)], and Rauvolfia vomitoria [Asofeyeje (Root)] using the ..
  45. ncbi [Speciation analysis of eight metal elements in the leaves of Alstonia scholaris by flame atomic adsorption spectrometry]
    Yan Qing Ye
    School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:3416-9. 2009
    The eight elements, Cu, Zn, Fe, Mg, Ca, Cr, Mn and Cd, in the leaves of Alstonia scholaris were extracted based on traditional analytical flowchart program and separated into water-soluble state and suspension state by micro porous ..
  46. pmc Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo
    Soo Jin Lee
    AMOREPACIFIC CO R and D Center, Bora dong, Giheung gu, Yongin si, Gyeonggi do 449 729, Republic of Korea
    Evid Based Complement Alternat Med 2012:190370. 2012
    ..The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br...
  47. pmc Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species
    Siu Kuin Wong
    School of Science, Monash University Sunway Campus, Bandar Sunway, 46150 Petaling Jaya, Selangor, Malaysia
    BMC Complement Altern Med 11:3. 2011
    ..In this study, leaf extracts of five selected species of Apocynaceae used in traditional medicine (Alstonia angustiloba, Calotropis gigantea, Dyera costulata, Kopsia fruticosa and Vallaris glabra) were assessed for ..
  48. doi A new type of monoterpenoid indole alkaloid precursor from Alstonia rostrata
    Xiang Hai Cai
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
    Org Lett 13:3568-71. 2011
    ..However, our phytochemical research on Alstonia rostrata revealed a potential new precursor for these compounds...
  49. doi Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine
    Shin Jowl Tan
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 73:1891-7. 2010
    A total of 25 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia spatulata, of which five are new alkaloids of the strychnan type (alstolucines A-E, 1-5) and the other, a new alkaloid of the secoangustilobine A type (..
  50. ncbi Evaluation of air pollution tolerance index of selected plant species along roadsides in Thiruvananthapuram, Kerala
    S Jissy Jyothi
    Department of Environmental Sciences, University of Kerala, Kariavattom P O, Thiruvananthapuram 695 581, India
    J Environ Biol 31:379-86. 2010
    ..b>Alstonia scholaris, R. Br., Mangifera indica, L., and shrubs Clerodendron infortunatum, L., Eupatorium odoratum, L...
  51. doi Alsmaphorazines A and B, novel indole alkaloids from Alstonia pneumatophora
    Koichiro Koyama
    Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41 Shinagawa ku, Tokyo 142 8501, Japan
    Org Lett 12:4188-91. 2010
    Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis...
  52. ncbi Modulation of antineoplastic activity of cyclophosphamide by Alstonia scholaris in the Ehrlich ascites carcinoma-bearing mice
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    J Exp Ther Oncol 3:272-82. 2003
    Alterations in the neoplastic activity of cyclophosphamide (CPA) by the extract of Alstonia scholaris(ASE) were studied in mice transplanted with Ehrlich ascites carcinoma (EAC)...
  53. doi Alstonia scholaris Linn R Br in the treatment and prevention of cancer: past, present, and future
    - Manjeshwar Shrinath Baliga
    Father Muller Medical College, Mangalore, Karnataka, India
    Integr Cancer Ther 9:261-9. 2010
    b>Alstonia scholaris, commonly known as devil's tree, is an important medicinal plant in the various folk and traditional systems of medicine in Asia, Australia, and Africa...
  54. doi Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora
    Koichiro Koyama
    Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 18:4415-21. 2010
    Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods...
  55. doi Potential of a Khaya ivorensis -Alstonia boonei extract combination as antimalarial prophylactic remedy
    Roselyne Nzangue Tepongning
    University of Camerino, School of Pharmacy, Piazza dei Costanti, 62032 Camerino MC, Italy
    J Ethnopharmacol 137:743-51. 2011
    The decoction of the combined stem barks of Khaya ivorensis A. Chev. (Meliaceae) and Alstonia boonei De Wild (Apocynaceae) has a history of use in traditional medicine of central Cameroon for malaria treatment but also for the prevention ..
  56. doi Monoterpenoid indole alkaloids from the bark of Alstonia scholaris
    Tao Feng
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P R China
    Planta Med 75:1537-41. 2009
    ..alkaloids, scholarisines B-G (1- 6), together with 15 known analogues (7- 21), were isolated from the bark of Alstonia scholaris. Their structures were determined by 1D and 2D NMR spectra and MS analyses...
  57. ncbi Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark
    O A Olajide
    Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Ethnopharmacol 71:179-86. 2000
    The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0...
  58. ncbi Molluscicidal evaluation of three common plants from India
    Ajay Singh
    Natural Products Laboratory, Department of Zoology, DDU Gorakhpur University, Gorakhpur 273 009 U P, India
    Fitoterapia 76:747-51. 2005
    Mortality caused by the aqueous extract of latex of Thevetia peruviana, Alstonia scholaris and Euphorbia pulcherrima against two harmful freshwater snails, Lymnaea acuminata and Indoplanorbis exustus, is reported...
  59. ncbi Evaluation of the cytotoxic effect of the monoterpene indole alkaloid echitamine in-vitro and in tumour-bearing mice
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    J Pharm Pharmacol 57:1213-9. 2005
    ..Our study demonstrated that echitamine chloride possessed anti-tumour activity in-vitro and in-vivo...
  60. ncbi Effect of Sapthaparna (Alstonia scholaris Linn) in modulating the benzo(a)pyrene-induced forestomach carcinogenesis in mice
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576119, Karnataka, India
    Toxicol Lett 144:183-93. 2003
    The chemopreventive effect of various doses of hydroalcoholic extract of Alstonia scholaris (ASE) was studied on the benzo(a)pyrene (BaP) induced forestomach carcinoma in female mice. The treatment of mice with different doses, i.e...
  61. ncbi Isoprene emission from tropical tree species
    P K Padhy
    School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Environ Pollut 135:101-9. 2005
    ..Mangifera indica, Melia azedarach, and Syzygium jambolanum), whereas, in the remaining three tree species (Alstonia scholaris, Azadirachta indica, and Cassia fistula) no isoprene emission was detected or the levels of emission ..
  62. ncbi An asymmetric synthesis of both enantiomers of the indole alkaloid deplancheine
    Steven M Allin
    Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, England
    J Org Chem 70:357-9. 2005
    ..We report a novel, facile and asymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, nonracemic chiral template. The natural product and its antipode are isolated with >95% ee...
  63. ncbi The effect of seasonal variation on the antineoplastic activity of Alstonia scholaris R. Br. in HeLa cells
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, India
    J Ethnopharmacol 96:37-42. 2005
    In order to evaluate the seasonal variation as well as cytotoxicity of different fractions of Alstonia scholaris R. Br...
  64. ncbi The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    J Med Food 7:343-8. 2004
    ..The potency of scavenging activity was in the following order: Alstonia scholaris > Cynodon dactylon > Morinda citrifolia > Tylophora indica > Tectona grandis > Aegle ..
  65. ncbi Effect of Alstonia scholaris in enhancing the anticancer activity of berberine in the Ehrlich ascites carcinoma-bearing mice
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, Karnataka, India
    J Med Food 7:235-44. 2004
    The chemomodulatory activity of Alstonia scholaris extract (ASE) was studied in combination with berberine hydrochloride (BCL), a topoisomerase inhibitor, in Ehrlich ascites carcinoma-bearing mice...
  66. ncbi Treatment with Alstonia scholaris enhances radiosensitivity in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Cancer Biother Radiopharm 18:917-29. 2003
    The radiosensitizing effect of 5 micrograms/mL of alkaloid fraction of Alstonia scholaris (ASERS) was evaluated in various neoplastic cell lines, namely: HeLa, HePG2, HL60, MCF-7, and KB exposed to 0, 0...
  67. ncbi Induction of developmental toxicity in mice treated with Alstonia scholaris (Sapthaparna) In utero
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Birth Defects Res B Dev Reprod Toxicol 68:472-8. 2003
    The teratogenic effect of hydroalcoholic extract of Alstonia scholaris (ASE) was studied in the pregnant Swiss albino mice administered with 0, 60, 120, 240, 360, and 480 mg/kg ASE on Day 11 of gestation.
  68. ncbi Antibacterial activity of Alstonia scholaris and Leea tetramera
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B Lae, Papua New Guinea
    Fitoterapia 74:736-40. 2003
    The crude methanolic extracts of the leaves, stem and root barks of Alstonia scholaris and Leea tetramera on partitioning (petrol, dichloromethane, ethyl acetate, butanol) gave fractions exhibiting improved and broader spectrum of ..
  69. ncbi Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-N(a)-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine
    Xiaoxiang Liu
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA
    Org Lett 4:3339-42. 2002
    ..reaction: see text]..
  70. ncbi Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts
    M I Iwo
    Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Ganesa, Indonesia
    Clin Hemorheol Microcirc 23:177-83. 2000
    The immunostimulating effect of "Pule" (Alstonia scholaris (L.) R.Br., Apocynaceae) bark extracts was studied in BALB/c mouse. The extracts were administered orally, once a day for 7 consecutive days...
  71. pmc Leaf life span plasticity in tropical seedlings grown under contrasting light regimes
    Gregoire Vincent
    Institut de Recherche pour le Développement IRD UMR AMAP, TA40 PS2, 34398 Montpellier Cedex 5, France
    Ann Bot 97:245-55. 2006
    ..This study evaluates the plasticity of leaf longevity, in terms of its quantitative importance to the plant carbon balance under limiting light...
  72. ncbi Induction of antifertility with lupeol acetate in male albino rats
    R S Gupta
    Reproduction Physiology Section, Department of Zoology, S S Jain Subodh PG College, Jaipur, India
    Pharmacology 75:57-62. 2005
    ..e. lupeol acetate, isolated from benzene extract of Alstonia scholaris in male albino rats...
  73. doi Antidiarrhoeal and spasmolytic activities of the methanolic crude extract of Alstonia scholaris L. are mediated through calcium channel blockade
    Abdul Jabbar Shah
    Drug Discovery and Natural Products Research Unit, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 24:28-32. 2010
    This study was aimed to provide a pharmacological basis to the medicinal use of Alstonia scholaris as an antidiarrhoeal and antispasmodic by using in vivo and in vitro techniques...
  74. ncbi Effect of Alstonia scholaris (Linn.) R. Br. on stress and cognition in mice
    Mrugaya P Kulkarni
    Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai 400 019, India
    Indian J Exp Biol 47:47-52. 2009
    Effect of stress and its modulation by methanolic extract of bark of Alstonia scholaris was studied using acute restraint stress model in mice...
  75. pmc Absolute configuration of actinophyllic acid as determined through chiroptical data
    Tohru Taniguchi
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    J Nat Prod 72:430-2. 2009
    ..acid skeleton isolated from Alstonia actinophylla, was determined through the study of its corresponding methyl ester 2...
  76. doi Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla
    Yusuke Hirasawa
    Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41 Shinagawa, Tokyo 142 8501, Japan
    J Nat Prod 72:304-7. 2009
    Four new alkaloids, alstiphyllanines A-D (1-4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses...
  77. doi Management of corm-rot disease of Gladiolus by plant extracts
    Tariq Riaz
    Institute of Mycology and Plant Pathology, University of the Punjab, Quaid e Azam Campus, Lahore, Pakistan
    Nat Prod Res 24:1131-8. 2010
    ..Juss. (neem), Alstonia scholaris (L.) R. Br., Lawsonia alba Lam., Allium cepa L., A. sativum L...
  78. ncbi Sperm motility inhibiting activity of a phytosterol from Alstonia macrophylla Wall ex A. DC. leaf extract: a tribal medicine
    Debprasad Chattopadhyay
    ICMR Virus Unit, Infectious Diseases and Beliaghata General Hospital, General Block 4, 1st Floor, 57 Dr Suresh Chandra Banerjee Road, Kolkata 700 010, India
    Indian J Exp Biol 43:1104-9. 2005
    ..The results demonstrate that Fraction A (beta-sitosterol) is a potent inhibitor of sperm motility and thus it has the potential to serve as a vaginal contraceptive...
  79. doi Bipleiophylline, an unprecedented cytotoxic bisindole alkaloid constituted from the bridging of two indole moieties by an aromatic spacer unit
    Toh Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Org Lett 10:3749-52. 2008
    ..structure in which two indole moieties are bridged by an aromatic spacer unit has been isolated from Alstonia angustifolia...
  80. ncbi Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands
    Debprasad Chattopadhyay
    ICMR Virus Unit, Infectious Diseases and Beliaghata General Hospital, Beliaghata, Kolkata
    J Pharm Pharm Sci 8:558-64. 2005
    b>Alstonia macrophylla Wall ex A. DC. Leaf, used in different ailments by the Onge tribes of Little Andaman Island, India, was investigated for its antipyretic potential.
  81. doi Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba
    Koichiro Koyama
    Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 16:6483-8. 2008
    Five new alkaloids, alstilobanines A (1)-E (5) were isolated from Alstonia angustiloba (Apocynaceae) and their structures were determined by MS and 2D NMR spectral analysis...
  82. ncbi Enantiospecific synthesis of (+)-N(a)-methylpericyclivine and (-)-N(a)-methylakuammidine as well as the ring-A oxygenated natural products, (+)-10-methoxy N(a)-methylpericyclivine and 10-hydroxy N(a)-methylpericyclivine
    P V V Srirama Sarma
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    Org Lett 8:1017-20. 2006
    ..The lactones (see 19, 22, and 25) are key to the formation of the beta-axial methyl ester moiety...
  83. ncbi Unique monoterpenoid indole alkaloids from Alstonia scholaris
    Xiang Hai Cai
    State Key Laboratory of Phytichemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Scienes, Kunming 650204, China
    Org Lett 9:1817-20. 2007
    ..named (19,20) E-alstoscholarine (1) and (19,20) Z-alstoscholarine (2), were obtained from the leaf extract of Alstonia scholaris...
  84. ncbi Modification of benzo(a)pyrene-(BaP)-induced forestomach carcinogenesis in mice by means od extract of the bark of Astonia scholaris (ASE)
    Armen K Nersesyan
    Toxicol Lett 154:159-60; author reply 161. 2004
  85. doi Diversity and screening for antimicrobial activity of endophytic fungi from Alstonia scholaris
    S Mahapatra
    Vidyasagar University, Department of Microbiology, Midnapore 721102, West Bengal, India
    Acta Microbiol Immunol Hung 57:215-23. 2010
    Endophytic fungi of three tissues (petiole, bark and leaf) of Alstonia scholaris were assessed...
  86. doi Anticancer activity of an Indian medicinal plant, Alstonia scholaris, on skin carcinogenesis in mice
    Swafiya Jahan
    University of Rajasthan, Jaipur, India
    Integr Cancer Ther 8:273-9. 2009
    b>Alstonia scholaris, commonly known as sapthaparna, has been used for centuries in Ayurvedic medicine for treatment of various disorders...
  87. ncbi Stereocontrolled total synthesis of (-)-vincamajinine and (-)-11-methoxy-17-epivincamajine
    Jianming Yu
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    J Am Chem Soc 126:1358-9. 2004
    ..The unique highly conjested carbon skeletons of the two alkaloids were completed in a concise manner and in regiospecific fashion...
  88. ncbi Dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands
    D Chattopadhyay
    ICMR Virus Unit, ID and BG Hospital, Kolkata, India
    Chemotherapy 52:151-7. 2006
    The methanol extract of Ophirrhiza nicobarica, Alstonia macrophylla and Mallotus peltatus, ethnomedicines of Little Andaman, were investigated for antiinfective, antiinflammatory and antioxidant activities.
  89. ncbi New indole alkaloids from Alstonia macrophylla
    Toh Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 67:547-52. 2004
    ..alstophyllal (8), 6-oxoalstophylline (9), and 6-oxoalstophyllal (10), in addition to 21 other known ones, were obtained from the leaf extract of the Malayan Alstonia macrophylla. The structures were determined using NMR and MS analysis.
  90. ncbi The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine
    Xuebin Liao
    Department of Chemistry, University of Wisconsin Milwaukee, 3210 North Cramer Street, Milwaukee, WI 53211, USA
    Org Lett 7:3501-4. 2005
    ..This one-pot sequence provides facile entry into the dihydropyranyl enone unit of many Alstonia alkaloids. [structure: see text]
  91. ncbi The enantiospecific, stereospecific total synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine, as well as the total synthesis of the alstonia bisindole alkaloid macralstonidin
    Shuo Zhao
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    J Org Chem 68:6279-95. 2003
    ..8), (+)-majvinine (14), and (+)-10-methoxyaffinisine (49), as well as the first total synthesis of the Alstonia bisindole alkaloid macralstonidine (9), has been accomplished...
  92. ncbi Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine
    Xiangyu Z Wearing
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    Org Lett 4:4237-40. 2002
    ..The structure of alstonisine (1) has been determined by NOE spectroscopic experiments and was confirmed by single-crystal X-ray analysis...
  93. doi A new indole alkaloid from Alstonia scholaris
    Luna Jain
    Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Nat Prod Res 23:1599-602. 2009
    ..N-formylscholarine, together with picrinine, strictamine and nareline has been isolated from the fruit pods of Alstonia scholaris, and their structures were established by various spectral data...
  94. ncbi CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands
    Debprasad Chattopadhyay
    ICMR Virus Unit Calcutta, Infectious Diseases and Beliaghata General Hospital, GB 4, 1st Floor, 57, Dr Suresh Banerjee Road, Kolkata 700 010, India
    Fitoterapia 75:673-82. 2004
    Methanol extract at 100-200 mg/kg p.o. and major nonpolar fraction B at 50 mg/kg of Alstonia macrophylla leaves caused a significant reduction in spontaneous activity, remarkable decrease in exploratory behavioural pattern, a reduction in ..
  95. ncbi Venalstonine and dioxokopsan derivatives from Kopsia fruticosa
    Toh Seok Kam
    Department of Chemistry, University of Malaya, Pantai Valley, 50603 Kuala Lumpur, Malaysia
    Phytochemistry 65:2119-22. 2004
    ..The structures of the new alkaloids were determined using NMR and MS analysis...