transgenic mice

Summary

Summary: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO.

Top Publications

  1. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  2. ncbi Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
  3. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
  4. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
  5. ncbi A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    Shiaoching Gong
    GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
    Nature 425:917-25. 2003
  6. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
  7. ncbi TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
    Iga Wegorzewska
    Department of Neurology and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:18809-14. 2009
  8. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
  9. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
  10. ncbi Onset and progression in inherited ALS determined by motor neurons and microglia
    Severine Boillee
    Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 312:1389-92. 2006

Research Grants

  1. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2009
  2. Fibrotic Sequelae of Childhood Renal Disease
    Agnes Fogo; Fiscal Year: 2007
  3. AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia
    MARKUS MUSCHEN; Fiscal Year: 2009
  4. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
  5. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
  6. PATHOGENESIS, IMMUNODIAGNOSIS AND THERAPY OF HCC
    Jack Wands; Fiscal Year: 2007
  7. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
  8. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2009
  9. Androgen receptor targeted vaccines for prostate cancer
    Douglas G McNeel; Fiscal Year: 2010
  10. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007

Detail Information

Publications287 found, 100 shown here

  1. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  2. ncbi Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
    ....
  3. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
    ....
  4. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
    ..to alanine at position 93--a change that has little effect on enzyme activity--caused motor neuron disease in transgenic mice. The mice became paralyzed in one or more limbs as a result of motor neuron loss from the spinal cord and ..
  5. ncbi A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    Shiaoching Gong
    GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
    Nature 425:917-25. 2003
    ..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously ..
  6. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
    ..In three lines, the transgene is ubiquitously expressed at both mRNA and protein level. Transgenic mice exhibit a progressive neurological phenotype that exhibits many of the features of HD, including choreiform-..
  7. ncbi TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
    Iga Wegorzewska
    Department of Neurology and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:18809-14. 2009
    ....
  8. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  9. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  10. ncbi Onset and progression in inherited ALS determined by motor neurons and microglia
    Severine Boillee
    Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 312:1389-92. 2006
    ....
  11. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
    ..Conditional mutagenesis of Gr in the nervous system provides genetic evidence for the importance of Gr signalling in emotional behaviour because mutant animals show an impaired behavioural response to stress and display reduced anxiety...
  12. ncbi Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
    Nohjin Kee
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Nat Neurosci 10:355-62. 2007
    ..This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus...
  13. ncbi Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    P S Danielian
    Department of Molecular and Cellular Biology Harvard University 16 Divinity Avenue, Cambridge Massachusetts 02138 USA
    Curr Biol 8:1323-6. 1998
    ..Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo...
  14. ncbi Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    Yanping Li
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA
    Nat Neurosci 12:826-8. 2009
    ..These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics...
  15. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  16. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  17. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  18. ncbi TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
    Hans Wils
    Department of Molecular Genetics, VIB, B 2610 Antwerpen, Belgium
    Proc Natl Acad Sci U S A 107:3858-63. 2010
    ..These findings suggest that approximately 25-kDa TDP-43 CTFs are noxious to neurons by a gain of aberrant nuclear function...
  19. ncbi A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  20. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
  21. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
    ..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
  22. ncbi Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Science 293:1491-5. 2001
    ..Injection of beta-amyloid Abeta42 fibrils into the brains of P301L mutant tau transgenic mice caused fivefold increases in the numbers of NFTs in cell bodies within the amygdala from where neurons ..
  23. ncbi Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 3:541-7. 1995
    ..In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury...
  24. ncbi Tau suppression in a neurodegenerative mouse model improves memory function
    K SantaCruz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Science 309:476-81. 2005
    ..Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy...
  25. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild-type human alpha-synuclein were generated...
  26. ncbi Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
    Ya Fei Xu
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neurosci 30:10851-9. 2010
    ..This TDP-43 transgenic line provides a valuable tool for identifying potential roles of wild-type TDP-43 within the CNS and for studying TDP-43-associated neurotoxicity...
  27. ncbi Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice
    Emmanuel Valjent
    INSERM, UMR S 839, 75005 Paris, France
    Trends Neurosci 32:538-47. 2009
    ..The recent development of bacterial artificial chromosome (BAC) transgenic mice expressing a variety of reporters, epitope tagged-proteins or Cre recombinase driven by specific promoters, ..
  28. ncbi Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    S W Davies
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Cell 90:537-48. 1997
    ..The appearance in transgenic mice of these inclusions, followed by characteristic morphological change within neuronal nuclei, is strikingly ..
  29. ncbi Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    A M Clement
    Ludwig Institute for Cancer Research, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0670, USA
    Science 302:113-7. 2003
    ..Normal motor neurons in SOD1 mutant chimeras develop aspects of ALS pathology. Most important, nonneuronal cells that do not express mutant SOD1 delay degeneration and significantly extend survival of mutant-expressing motor neurons...
  30. ncbi RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    Y Shinkai
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 68:855-67. 1992
    ..Because the SCID phenotype was the only obvious abnormality detected in RAG-2 mutant mice, RAG-2 function and V(D)J recombinase activity, per se, are not required for development of cells other than lymphocytes...
  31. ncbi Conditional gene targeting in macrophages and granulocytes using LysMcre mice
    B E Clausen
    Institute for Genetics, University of Cologne, Germany
    Transgenic Res 8:265-77. 1999
    ..In contrast, no significant deletion was observed in tail DNA or purified T and B cells. Taken together, LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells...
  32. ncbi Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
    Margaret Wong
    Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, 558 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Hum Mol Genet 19:2284-302. 2010
    ..The discovery of instigating molecular toxicities or disease progression determinants within skeletal muscle could be very valuable for the development of new effective therapies for the treatment and cure of ALS...
  33. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  34. ncbi PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
    ..These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level...
  35. ncbi A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
    ....
  36. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..2004</citeref>).</title> <fig id="fig1" name="GGRF0233fig001"></fig> </figgrp>..
  37. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
    b>Transgenic mice expressing a stabilized beta-catenin in neural precursors develop enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals...
  38. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  39. ncbi Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    Erik D Roberson
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 316:750-4. 2007
    ..Here, we found that reducing endogenous tau levels prevented behavioral deficits in transgenic mice expressing human amyloid precursor protein, without altering their high Abeta levels...
  40. ncbi Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 36:585-95. 2004
    ..we show that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains...
  41. ncbi Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
    J Neurosci 28:8354-60. 2008
    ..Antiinflammatory therapy for AD should take this dichotomous microglial role into consideration...
  42. ncbi Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    Salvatore Oddo
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 43:321-32. 2004
    ..These findings indicate that Abeta immunization may be useful for clearing both hallmark lesions of AD, provided that intervention occurs early in the disease course...
  43. ncbi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  44. ncbi Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    H Cho
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 292:1728-31. 2001
    ..These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis...
  45. ncbi Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
    Xiu Shan
    Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 107:16325-30. 2010
    ..In concert, our findings indicate that TDP-43 participates in pathways critical for motor neuron physiology, including those that regulate the normal distributions of SMN-associated GEMs in the nucleus and mitochondria in the cytoplasm...
  46. ncbi Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    J J Lucas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    EMBO J 20:27-39. 2001
    ..By using the tet-regulated system we have produced conditional transgenic mice overexpressing GSK-3beta in the brain during adulthood while avoiding perinatal lethality due to embryonic ..
  47. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  48. ncbi Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Development 130:391-9. 2003
    ..In transgenic mice expressing enhanced green fluorescent protein under the nestin promoter none of the BrdU/nestin-positive ..
  49. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Introduction of a PD-1 null mutation into the 2C-TCR (anti-H-2Ld) transgenic mice of the H-2(b/d) background resulted in the chronic and systemic graft-versus-host-like disease...
  50. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ..Using bacterial artificial chromosome transgenic mice that label a defined class of perisomatic synapses with green fluorescent protein, here we show that ..
  51. ncbi Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 185:232-40. 2004
    ..We conclude that in this widely studied animal model of human ALS, and in this single human case, motor neuron pathology begins at the distal axon and proceeds in a "dying back" pattern...
  52. ncbi The transcriptional repressor Snail promotes mammary tumor recurrence
    Susan E Moody
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cancer Cell 8:197-209. 2005
    ..In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence...
  53. ncbi Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
    Carlos Lois
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 295:868-72. 2002
    Single-cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter...
  54. ncbi Oscillations in notch signaling regulate maintenance of neural progenitors
    Hiromi Shimojo
    Institute for Virus Research, Kyoto University, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Neuron 58:52-64. 2008
    ..These results suggest that Hes1 oscillation regulates Ngn2 and Dll1 oscillations, which in turn lead to maintenance of neural progenitors by mutual activation of Notch signaling...
  55. ncbi Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    Emiley Pham
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    FEBS J 277:3051-67. 2010
    ..Similarly, in transgenic mice expressing high levels of neuronal amyloid precursor protein, amyloid-beta co-immunoprecipitated with ..
  56. ncbi Bmi1 is expressed in vivo in intestinal stem cells
    Eugenio Sangiorgi
    Howard Hughes Medical Institute and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Nat Genet 40:915-20. 2008
    ..Unexpectedly, the distribution of Bmi1-expressing stem cells along the length of the small intestine suggested that mammals use more than one molecularly distinguishable adult stem cell subpopulation to maintain organ homeostasis...
  57. ncbi In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  58. ncbi Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    Holly Oakley
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:10129-40. 2006
    ..b>Transgenic mice that express FAD mutant APP and PS1 overproduce Abeta42 and exhibit amyloid plaque pathology similar to that ..
  59. ncbi Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1
    Sanbing Shen
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom
    J Neurosci 28:10893-904. 2008
    ..To model this mutation in mice, we have generated Disc1(tr) transgenic mice expressing 2 copies of truncated Disc1 encoding the first 8 exons using a bacterial artificial chromosome (..
  60. ncbi Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, 3600 Spruce Street, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 34:521-33. 2002
    ..To explore this issue, we generated transgenic mice expressing wild-type and A53T human alpha-synuclein in CNS neurons...
  61. ncbi Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
    W L Klein
    Northwestern University Institute for Neuroscience and Dept of Neurobiology and Physiology, Northwestern University, 2153 N Campus Drive, Evanston, IL 60208, USA
    Trends Neurosci 24:219-24. 2001
    ..Immuno-neutralization of soluble Abeta-derived toxins might be the key to optimizing AD vaccines that are now on the horizon...
  62. ncbi Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 197:1073-81. 2003
    ..We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG)...
  63. ncbi Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 198:235-47. 2003
    ..The capacity to expand CD25+ CD4+ T cells provides DCs with an additional mechanism to regulate autoimmunity and other immune responses...
  64. ncbi Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    Koji Yamanaka
    Ludwig Institute for Cancer Research and Department of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0670, USA
    Nat Neurosci 11:251-3. 2008
    ..These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS...
  65. ncbi Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  66. ncbi ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
    ..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury...
  67. ncbi Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
    ..investigate whether kinase inhibition can reduce tauopathy and the degeneration associated with it in vivo, transgenic mice overexpressing mutant human tau were treated with the glycogen synthase kinase-3 (GSK-3) inhibitor lithium ..
  68. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis...
  69. ncbi IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    Stefan Haak
    Neuroimmunology Division, Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Clin Invest 119:61-9. 2009
    ..To study the impact of IL-17A on CNS inflammation, we generated transgenic mice in which high levels of expression of IL-17A could be initiated after Cre-mediated recombination...
  70. ncbi PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    C Dai
    Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 15:1913-25. 2001
    ..Loss of Ink4a-Arf is not required for PDGF-induced glioma formation but promotes tumor progression toward a more malignant phenotype...
  71. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
    ..We sorted lineage-negative (Lin-) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein by fluorescence-activated cell sorting on the basis of c-kit ..
  72. ncbi Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 13:159-70. 2004
    ..mutations in PS1 (and PS2) occur in patients with early-onset familial AD (FAD), and previous studies in transgenic mice and cultured cell models demonstrated that FAD-PS1 variants shift the ratio of Abeta40 : 42 to favor Abeta42...
  73. ncbi Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  74. ncbi Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
    ....
  75. ncbi Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice
    Miriam Matamales
    Inserm UMR S 839, Paris, France
    PLoS ONE 4:e4770. 2009
    ..has been a continuous subject of debate, and the recent introduction of bacterial artificial chromosome (BAC) transgenic mice expressing fluorescent proteins driven by specific promoters was a major progress to facilitate striatal ..
  76. ncbi Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
    J Steven Jacobsen
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 103:5161-6. 2006
    ..Overall, these data show that the perforant path input from the entorhinal cortex to the DG is compromised both structurally and functionally, and this pathology is manifested in memory defects long before significant plaque deposition...
  77. ncbi Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    E C Holland
    Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 25:55-7. 2000
    ..11), and we show here that Akt activity is increased in most of these tumours, implying that combined activation of these two pathways accurately models the biology of this disease...
  78. ncbi Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
    Ko-Woon Lee
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3399-404. 2006
    ..These studies made use of transgenic mice that expressed EGFP under the control of either the D1 or D2 receptor promoter (Drd1-EGFP or Drd2-EGFP)...
  79. ncbi Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    J P Silva
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Nat Genet 26:336-40. 2000
    ..This animal model reproduces the beta-cell pathology of human mitochondrial diabetes and provides genetic evidence for a critical role of the respiratory chain in insulin secretion...
  80. ncbi Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs
    Shiaoching Gong
    Gene Expression Nervous System Atlas Project, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 27:9817-23. 2007
  81. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast ..
  82. ncbi Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    F C Nucifora
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Science 291:2423-8. 2001
    ..from its normal nuclear location and was present in polyglutamine aggregates in HD cell culture models, HD transgenic mice, and human HD postmortem brain...
  83. ncbi The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
    Herve Guillou
    Integrative Toxicology and Metabolism, Pôle de Toxicologie Alimentaire, Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse Cedex 3, France
    Prog Lipid Res 49:186-99. 2010
    ....
  84. ncbi Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 9:188-97. 2010
    ..Pineal hormone also inhibits mammary carcinoma development in HER2/neu transgenic mice as well as in female SHR mice...
  85. ncbi Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia
    Jessica A Shuen
    Center for Translational Neuroscience, Division of Neurology, Neurotransgenic Core Facility, and Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 28:2681-5. 2008
  86. ncbi Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania
    Jos Prickaerts
    Division of Psychiatry, Johnson and Johnson Pharmaceutical Research and Development, B 2340 Beerse, Belgium
    J Neurosci 26:9022-9. 2006
    ..We therefore investigated the possibility that transgenic mice overexpressing GSK-3beta could be of relevance to model bipolar disorder...
  87. ncbi Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    S Engelhardt
    Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 96:7059-64. 1999
    ..The transgenic mice had increased cardiac contractility at a young age but also developed marked myocyte hypertrophy (3...
  88. ncbi Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
  89. ncbi Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    M A Chishti
    Centre for Research in Neurodegenerative Diseases, The Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 276:21562-70. 2001
    ..The Tg mice described here suggest a potential to investigate aspects of Alzheimer's disease pathogenesis, prophylaxis, and therapy within short time frames...
  90. ncbi A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
  91. ncbi T-bet-dependent expression of osteopontin contributes to T cell polarization
    Mari L Shinohara
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:17101-6. 2005
    ..Taken together, these findings begin to delineate the genetic basis of Opn expression in T cells and further clarify the role of Opn in Th and Tc1 development...
  92. ncbi IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity
    Tomohiko Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2573-81. 2005
    ..Together, IRF-4 and IRF-8 serve as a backbone of the molecular program regulating DC subset development and their functional diversity...
  93. ncbi Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice
    Ziyad Al-Aly
    Division of Bone and Mineral Diseases, Washington University School of Medicine, Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110
    Arterioscler Thromb Vasc Biol 27:2589-96. 2007
    ..Because elevated TNF-alpha is characteristic of obesity with T2DM, we examined contributions of this inflammatory cytokine...
  94. ncbi Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation
    Kimiko Tatsumi
    The Department of Pediatrics, Kansai Medical University, Moriguchi, Japan
    Circ J 72:1351-8. 2008
    ..Hereditary disordered cardiac muscle could be replaced with intact cardiomyocytes derived from genetically intact bone marrow (BM)-derived stem cells...
  95. ncbi Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals
    Sachin Malhotra
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:3955-64. 2008
    ..We conclude that at least two Wnt ligands can differentially regulate early events in B lymphopoiesis, affecting entry and progression in distinct differentiation lineages...
  96. ncbi SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:3994-4003. 2008
    ..Instead, SAP is necessary for very late stages of differentiation or, most likely, for allowing Th cells to communicate during cognate T:B interactions...
  97. ncbi ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling
    Masashi Watanabe
    Division of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba, Japan
    J Immunol 174:1989-96. 2005
    ..These observations led us to propose that the predominant effect of ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4R-mediated signaling...
  98. ncbi OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:1433-7. 2005
    ..This would serve to limit inappropriate T cell responses. In contrast, OX40 signals from CD4(+)CD3(-) cells located in the outer T zone select proliferating Th2 effectors into the memory T cell pool...
  99. ncbi The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
    Alexandra Aicher
    Department of Internal Medicine III, J W Goethe University, Frankfurt, Germany
    Circ Res 103:796-803. 2008
    ..Using TOP-GAL transgenic mice to determine activation of beta-catenin, we demonstrate that Dkk-1 regulates endosteal cells in the bone ..
  100. ncbi Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
    Chiaki Takahashi
    Department of Medial Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Mol Cell Biol 24:10406-15. 2004
    ..These observations suggest that Rb and K-ras function together in vivo, in the contexts of both embryonic and tumor development, and that the ability to affect differentiation is a major facet of the tumor suppressor function of pRb...
  101. ncbi CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis
    René R S Packard
    Leducq Center for Cardiovascular Research and Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:965-73. 2008
    ..In particular, DCs remain functional antigen-presenting cells and maintain their ability to prime CD4(+) T cells even when cholesterol-loaded...

Research Grants80

  1. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2009
    ..of the NSAID flurbiprofen that lowers A42 but lacks cyclooxygenase inhibition reduces A burden in AD transgenic mice and is currently being tested in a phase III AD clinical trial...
  2. Fibrotic Sequelae of Childhood Renal Disease
    Agnes Fogo; Fiscal Year: 2007
    ..Am J Physiol Renal Physiol, 278: F 339-351, 2000. Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I: Bone morphogenetic protein 4 regulates the budding ..
  3. AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia
    MARKUS MUSCHEN; Fiscal Year: 2009
    ..compare development of Imatinib-resistance in Aid-/- and Aid-wildtype leukemias developing in BCR-ABL1 p190-transgenic mice. Aim 2: Contribution of AID-induced mutations to progression of CML into lymphoid blast crisis: To clarify to ..
  4. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..Syn overexpressing transgenic mice, as well as in .-Syn knock-out mice...
  5. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
    ..This is due to the fact that helminth-specific T cell receptors (TCR) have not been isolated to generate TCR transgenic mice. This situation is compounded by the fact that as of to date it is not possible to engineer antigen-..
  6. PATHOGENESIS, IMMUNODIAGNOSIS AND THERAPY OF HCC
    Jack Wands; Fiscal Year: 2007
    ..of Fas receptor expression, and/or induces the loss of pro-apoptotic mechanisms observed in the single IRS-1 transgenic mice. Specific Aim #2 - Further characterize a critical downstream effector gene (AAH) upregulated through ..
  7. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..b>Transgenic mice that express the PV-associated DQalpha and DQbeta genes (DQA1*0101, DQB1*0503) will be generated as an animal ..
  8. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2009
    ..In aim 4C, we will systematically deliver vivo-morpholinos against Pitx1 to the Pitx1 transgenic mice. The goal is to determine if the vivo-morpholinos can suppress the transgene and reverse the phenotype, as ..
  9. Androgen receptor targeted vaccines for prostate cancer
    Douglas G McNeel; Fiscal Year: 2010
    ..This will be evaluated in HLA-A2 transgenic mice, and in an HLA-A2-expressing transgenic mouse model of prostate cancer...
  10. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
    ..We recently tested this axis by surmising that transgenic mice over-expressing TNAP might be able to achieve tissular expression of TNAP sufficiently high to be able to ..
  11. Role of HLA class II genes in demyelination
    Chella S David; Fiscal Year: 2010
    ..which HLA-DR and -DQ genes contribute to susceptibility and resistance to MS, we generated single and double transgenic mice expressing HLA class II genes and lacking endogenous mouse class II genes...
  12. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna Cordary; Fiscal Year: 2010
    ..on skinned papillary muscle fibers as well as force and calcium transients on intact muscle fibers from transgenic mice (Aim 2A)...
  13. Mechanism of gallbladder tumorigenesis in BK5.erbB2 mice
    Kaoru Kiguchi; Fiscal Year: 2007
    ..We recently developed the BK5.erbB2 transgenic mice where expression of a rat erbB2 cDNA is targeted to the basal layer of multiple epithelial tissues, including ..
  14. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2010
    ..of the NSAID flurbiprofen that lowers A42 but lacks cyclooxygenase inhibition reduces A burden in AD transgenic mice and is currently being tested in a phase III AD clinical trial...
  15. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    Humanized transgenic mice reproduce the disease evolution in severe RA Rheumatoid arthritis (RA) is a common autoimmune disease in humans genetically associated with specific HLA class II alleles...
  16. A MODEL FOR SICKLE CELL DISEASE & GENETIC THERAPIES
    Tim Townes; Fiscal Year: 1999
    In the past few years several groups have produced transgenic mice t hat synthesize high levels of human sickle hemoglobin (Hb S)...
  17. The Role of Cul4A in Genome Stability and Cancer Development
    Liang You; Fiscal Year: 2010
    ..We have generated a Cul4A transgenic mouse model. We are now ready to use the Cul4A transgenic mice to test our hypothesis that Cul4A is an oncogene...
  18. CORRECTION OF T-CELL AGING IN TRANSGENIC MICE
    JOHN MOUNTZ; Fiscal Year: 1993
    ..This proposal will study the fas apoptosis gene as a candidate LAG in CD2-fas transgenic mice. The fas apoptosis gene has recently been found to be mutated in autoimmune lprcg mice, and defective ..
  19. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    ..In this proposal, transgenic mice that show reduced expression of either Mn-SOD (Sod2+/-) or both Mn-SOD and the selenium-dependent glutathione ..
  20. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS
    Chella David; Fiscal Year: 2000
    ..we accomplished the monumental task of generating a humanized mouse model for polyarthritis using our HLA-DQ8 transgenic mice. In this proposal we will build this humanized mouse model to obtain all the critical information to ..
  21. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2007
    ..We generated transgenic mice expressing human class II genes...
  22. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail Pletnikov; Fiscal Year: 2009
    ..in levels and distribution of endogenous Disc1 and Its interacting proteins, Lis1 and Ndel1, in hDISC1 transgenic mice. Significance: The application is anticipated to advance our understanding of when, where and how mutant ..
  23. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail V Pletnikov; Fiscal Year: 2010
    ..in levels and distribution of endogenous Disc1 and Its interacting proteins, Lis1 and Ndel1, in hDISC1 transgenic mice. Significance: The application is anticipated to advance our understanding of when, where and how mutant ..
  24. AGGRECAN-hG1 AND LP TRANSGENIC MICE AS MODELS OF OSTEOARTHRITIS (OA)
    Tibor Glant; Fiscal Year: 2007
    ..We have generated transgenic mice overexpressing either LP or G1 domain (hG1) of human aggrecan in cartilage...
  25. Mechanisms of Acquired Central Transplantation Tolerance
    James Markmann; Fiscal Year: 2003
    ..this proposal, we will dissect the mechanisms of acquired central tolerance using a line of T cell receptor transgenic mice (TS1) in which a high percentage of CD4 T cells have class II restricted specificity for a dominant epitope (..
  26. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..In previously published studies and preliminary data, the investigators describe the production of transgenic mice expressing chimeric MHC class II molecules in which the peptide binding domain of the beta subunit is derived ..
  27. Keratin proteins and non-melanoma skin tumors
    PIERRE COULOMBE; Fiscal Year: 2007
    ..do so by mating previously characterized K17 null mice, in which the K17 protein is completely missing, with transgenic mice that constitutively express Gli2 in progenitor keratinocytes of the skin, and which reproducibly develop BCC ..
  28. Mouse Models of ErbB-2 and Cyclin D1 in Prostate Cancer
    Christopher Albanese; Fiscal Year: 2002
    ..We propose to test this hypothesis directly using transgenic mice. Determining the role of ErbB-2 and cyclin D1 in prostate cancer progression and determining the mechanisms ..
  29. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
    ..This is particularly important, since recent studies have demonstrated a trimodal distribution and >60-fold interindividual variation in the constitutive expression of CYP1A2 in human liver...
  30. Proteoglycans/Glycosaminoglycans in APP Transgenic Mice
    ALAN SNOW; Fiscal Year: 2004
    ..and 2) Detect and Quantify Heparan Sulfate GAGs Derived from Biological Fluids of Human AD Patients and APP Transgenic Mice, and Determine Their Utility as a Diagnostic Marker for AD...