Genomes and Genes
Summary: A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).
Publications262 found, 100 shown here
- BRAD, the genetics and genomics database for Brassica plantsFeng Cheng
Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China
BMC Plant Biol 11:136. 2011b>Brassica species include both vegetable and oilseed crops, which are very important to the daily life of common human beings...
- Rates of nucleotide substitution in angiosperm mitochondrial DNA sequences and dates of divergence between Brassica and other angiosperm lineagesY W Yang
Institute of Botany, Academia Sinica, Taipei, Taiwan 11529
J Mol Evol 48:597-604. 1999..5-20.4 Myr for the Brassica-Arabidopsis split, and 14.5-20.4 Myr for the Arabidopsis-Arabideae split.
- Mitochondrial genome sequencing helps show the evolutionary mechanism of mitochondrial genome formation in BrassicaShengxin Chang
State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, PR China
BMC Genomics 12:497. 2011..We analyzed the evolutionary relationships of Brassica mitotypes by sequencing.
- Trans-acting small RNA determines dominance relationships in Brassica self-incompatibilityYoshiaki Tarutani
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0192, Japan
Nature 466:983-6. 2010..expression of S-locus protein 11 genes (SP11), which encode the male determinants of self-incompatibility in Brassica. We previously reported that SP11 expression was monoallelic in some S heterozygotes, and that the promoter ..
- Direct ligand-receptor complex interaction controls Brassica self-incompatibilityS Takayama
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan
Nature 413:534-8. 2001Many higher plants have evolved self-incompatibility mechanisms to prevent self-fertilization. In Brassica self-incompatibility, recognition between pollen and the stigma is controlled by the S locus, which contains three highly ..
- Components of the Arabidopsis C-repeat/dehydration-responsive element binding factor cold-response pathway are conserved in Brassica napus and other plant speciesK R Jaglo
Department of Crop and Soil Science, Michigan State University, East Lansing, MI 48824, USA
Plant Physiol 127:910-7. 2001..Here, we present evidence for a CBF cold-response pathway in Brassica napus. We show that B...
- ARC1 is an E3 ubiquitin ligase and promotes the ubiquitination of proteins during the rejection of self-incompatible Brassica pollenSophia L Stone
Department of Botany, University of Toronto, Toronto, Ontario, Canada M5S 3B2
Plant Cell 15:885-98. 2003ARC1 is a novel U-box protein required in the Brassica pistil for the rejection of self-incompatible pollen; it functions downstream of the S receptor kinase (SRK)...
- Comparative analysis between homoeologous genome segments of Brassica napus and its progenitor species reveals extensive sequence-level divergenceFoo Cheung
The J Craig Venter Institute, Rockville, Maryland 20850, USA
Plant Cell 21:1912-28. 2009Homoeologous regions of Brassica genomes were analyzed at the sequence level...
- Numerous and rapid nonstochastic modifications of gene products in newly synthesized Brassica napus allotetraploidsWarren Albertin
UMR de Genetique Vegetale, INRA CNRS UPSud INA P G, La Ferme du Moulon, Gif sur Yvette, France
Genetics 173:1101-13. 2006..To investigate modifications of gene expression occurring during allopolyploid formation, the Brassica napus allotetraploid model was chosen...
- Asy1, a protein required for meiotic chromosome synapsis, localizes to axis-associated chromatin in Arabidopsis and BrassicaSusan J Armstrong
School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK
J Cell Sci 115:3645-55. 2002..Antibodies specific to Asy1 protein and its homologue BoAsy1 from the related crop species Brassica oleracea have been used to investigate the temporal expression and localization of the protein in both species...
- The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferationKarine Alix
UMR de Génétique Végétale INRA Univ Paris Sud CNRS AgroParisTech, Ferme du Moulon, F 91190 Gif sur Yvette, France
Plant J 56:1030-44. 2008We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1)...
- Genetic variation in defense chemistry in wild cabbages affects herbivores and their endoparasitoidsRieta Gols
Laboratory of Entomology, Department of Plant Sciences, Wageningen University, The Netherlands
Ecology 89:1616-26. 2008Populations of wild Brassica oleracea L. grow naturally along the Atlantic coastlines of the United Kingdom and France. Over a very small spatial scale (i.e...
- Efficient large-scale development of microsatellites for marker and mapping applications in Brassica crop speciesA J Lowe
IACR Long Ashton Research Station, Long Ashton, BS41 9AF, Bristol, UK
Theor Appl Genet 108:1103-12. 2004..398 simple sequence repeat markers (SSRs) have been developed and characterised for use with genetic studies of Brassica species. Small-insert (250-900 bp) genomic libraries from Brassica rapa, B. nigra, B. oleracea and B...
- Direct and indirect effects of resource quality on food web structureTibor Bukovinszky
Laboratory of Entomology, Wageningen University, Post Office Box 8031, 6700 EH Wageningen, Netherlands
Science 319:804-7. 2008..We conclude, on the basis of our data, that changes in the food web are dependent on both trait- and density-mediated interactions among species...
- Patterns of sequence loss and cytosine methylation within a population of newly resynthesized Brassica napus allopolyploidsLewis N Lukens
Department of Plant Agriculture, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Plant Physiol 140:336-48. 2006..To study the dynamics of genome change, we synthesized 49 isogenic Brassica napus allopolyploids and surveyed them with 76 restriction fragment length polymorphism (RFLP) probes and 30 ..
- Assessment of FAE1 polymorphisms in three Brassica species using EcoTILLING and their association with differences in seed erucic acid contentsNian Wang
National Centre of Plant Gene Research, Huazhong Agricultural University, Wuhan, China
BMC Plant Biol 10:137. 2010FAE1 (fatty acid elongase1) is the key gene in the control of erucic acid synthesis in seeds of Brassica species...
- The S receptor kinase determines self-incompatibility in Brassica stigmaT Takasaki
Research Institute of Seed Production Co, Ltd, Sendai, Japan
Nature 403:913-6. 2000The self-incompatibility possessed by Brassica is an intraspecific reproductive barrier by which the stigma rejects self-pollen but accepts non-self-pollen for fertilization...
- Chemical and biological characterisation of nutraceutical compounds of broccoliD A Moreno
Dept Ciencia y Tecnología de Alimentos and Dept Nutrición Vegetal, CEBAS CSIC, Apdo 164, 30100 Espinardo, Murcia, Spain
J Pharm Biomed Anal 41:1508-22. 2006..Numerous epidemiological studies indicate that Brassica vegetables in general, and broccoli in particular, protect humans against cancer since they are rich sources of ..
- SCAR and CAPS mapping of CRb, a gene conferring resistance to Plasmodiophora brassicae in Chinese cabbage ( Brassica rapa ssp. pekinensis)Z Y Piao
Department of Horticulture, College of Agriculture and Life Science, Chungnam National University, 305 764 Daejeon, Korea
Theor Appl Genet 108:1458-65. 2004..One dominant marker, TCR09, was located 0.78 cM from CRb. The remaining markers (TCR05, TCR01, TCR10, TCR08, and TCR03) were located on the other side of CRb, and the nearest of these was TCR05, at a distance of 1.92 cM...
- Genic microsatellite markers in Brassica rapa: development, characterization, mapping, and their utility in other cultivated and wild Brassica relativesNirala Ramchiary
Molecular Genetics and Genomics Lab, Department of Horticulture, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
DNA Res 18:305-20. 2011..Transferability analysis of 167 EST-SSRs in 35 species belonging to cultivated and wild brassica relatives showed 42.51% (Sysimprium leteum) to 100% (B. carinata, B. juncea, and B. napus) amplification...
- PCP-A1, a defensin-like Brassica pollen coat protein that binds the S locus glycoprotein, is the product of gametophytic gene expressionJ Doughty
Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
Plant Cell 10:1333-47. 1998Self-incompatibility (SI) in Brassica species is controlled by a single polymorphic locus (S) with multiple specificities...
- A pollen coat protein, SP11/SCR, determines the pollen S-specificity in the self-incompatibility of Brassica speciesH Shiba
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630-0101, Japan
Plant Physiol 125:2095-103. 2001..rapa by the same approach and further established that SP11/SCR is the sole male determinant of SI in the genus Brassica sp...
- Chlororespiration is involved in the adaptation of Brassica plants to heat and high light intensityMilagros Díaz
Departamento de Biologia Vegetal, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, E 30100 Murcia, Spain
Plant Cell Environ 30:1578-85. 2007Two species of Brassica were used to study their acclimation to heat and high illumination during the first stages of development...
- Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumorsJed W Fahey
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
Proc Natl Acad Sci U S A 99:7610-5. 2002....
- BnaC.Tic40, a plastid inner membrane translocon originating from Brassica oleracea, is essential for tapetal function and microspore development in Brassica napusXiaoling Dun
National Key Laboratory of Crop Genetic Improvement, National Center of Rapeseed Improvement, Huazhong Agricultural University, Wuhan 430070, China
Plant J 68:532-45. 2011Here, we describe the characteristics of a Brassica napus male sterile mutant 7365A with loss of the BnMs3 gene, which exhibits abnormal enlargement of the tapetal cells during meiosis...
- Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapaRyo Kimura
Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
Plant J 29:215-23. 2002The determinants of recognition specificity of self-incompatibility in Brassica are SRK in the stigma and SP11/SCR in the pollen, respectively. In the pair of S haplotypes BrS46 (S46 in B. rapa) and BoS7 (S7 in B...
- Microspore culture preferentially selects unreduced (2n) gametes from an interspecific hybrid of Brassica napus L. x Brassica carinata BraunMatthew N Nelson
Faculty of Natural and Agricultural Sciences, School of Plant Biology, The University of Western Australia, Crawley, WA 6009, Australia
Theor Appl Genet 119:497-505. 2009We analysed the products of male meiosis in microspore-derived progeny from a Brassica napus (AAC(n)C(n)) x Brassica carinata (BBC(c)C(c)) interspecific hybrid (ABC(n)C(c))...
- Transcriptional activation and localization of expression of Brassica juncea putative metal transport protein BjMTP1Balasubramaniam Muthukumar
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1392, USA
BMC Plant Biol 7:32. 2007..we present data on the transcriptional regulation and localization of expression of the homologous gene BjMTP1 in Brassica juncea. Though B...
- Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intakeJay H Fowke
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Carcinogenesis 27:2096-102. 2006Isothiocyanates and indoles (e.g. indole-3-carbinol) from Brassica vegetables (e.g. broccoli) induce Phase I and Phase II enzymes responsible for the oxidation, reduction and metabolism of endogenous and exogenous carcinogens...
- A Comparison of Semiochemically Mediated Interactions Involving Specialist and Generalist Brassica-feeding Aphids and the Braconid Parasitoid Diaeretiella rapaeJ D Blande
Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK
J Chem Ecol 33:767-79. 2007Diaeretiella rapae, a parasitoid that predominately specializes in the parasitism of Brassica-feeding aphids, attacks Lipaphis erysimi, a specialist feeding aphid of the Brassicaceae and other families in the Capparales, at a greater rate ..
- Phenolic compounds in Brassica vegetablesMaría Elena Cartea
Mision Biologica de Galicia, Consejo Superior de Investigaciones Cientificas CSIC, Apartado 28, 36080 Pontevedra, Spain
Molecules 16:251-80. 2011..The phenolic composition of Brassica vegetables has been recently investigated and, nowadays, the profile of different Brassica species is well ..
- Reduction of rare soil microbes modifies plant-herbivore interactionsW H Gera Hol
Netherlands Institute of Ecology NIOO KNAW, Department of Terrestrial Ecology, Boterhoeksestraat 48, 6666 GA Heteren, The Netherlands
Ecol Lett 13:292-301. 2010..It remains to be tested whether these are direct effects of rare soil microbes on plants and herbivores, or indirect effects via shifts in the microbial soil community assemblages...
- Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complexMarcus A Samuel
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada
Plant Cell 21:2655-71. 2009..In a screen for ARC1-interacting proteins, we have identified Brassica napus Exo70A1, a putative component of the exocyst complex that is known to regulate polarized secretion...
- Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa)G Suzuki
Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
Genetics 153:391-400. 1999In Brassica, two self-incompatibility genes, encoding SLG (S locus glycoprotein) and SRK (S-receptor kinase), are located at the S locus and expressed in the stigma...
- Male-derived butterfly anti-aphrodisiac mediates induced indirect plant defenseNina E Fatouros
Department of Plant Sciences, Laboratory of Entomology, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
Proc Natl Acad Sci U S A 105:10033-8. 2008..Our results suggest that the anti-aphrodisiac pheromone incurs fitness costs for the butterfly by both mediating phoretic behavior and inducing plant defense...
- Control of flowering time by FLC orthologues in Brassica napusM Tadege
Commonwealth Scientific and Industrial Research Organization, Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
Plant J 28:545-53. 2001..We isolated five FLC-related sequences from Brassica napus (BnFLC1-5)...
- Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotypeChristine B Ambrosone
Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, NY, USA
J Nutr 134:1134-8. 2004..No significant effects of GST genotype on risk were observed in either menopausal group. These data indicate that cruciferous vegetables may play an important role in decreasing the risk of premenopausal breast cancer...
- Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoliNathan V Matusheski
Department of Food Science and Human Nutrition, University of Illinois, 499 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL 61801, USA
Phytochemistry 65:1273-81. 2004..Heating to 70 degrees C and above decreased the formation of both products in broccoli florets, but not in broccoli sprouts. The induction of QR in cultured mouse hepatoma Hepa lclc7 cells paralleled increases in sulforaphane formation...
- Allele-specific receptor-ligand interactions in Brassica self-incompatibilityA Kachroo
Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA
Science 293:1824-6. 2001Genetic self-incompatibility in Brassica is determined by alleles of the transmembrane serine-threonine kinase SRK, which functions in the stigma epidermis, and of the cysteine-rich peptide SCR, which functions in pollen...
- A newly-developed community microarray resource for transcriptome profiling in Brassica species enables the confirmation of Brassica-specific expressed sequencesMartin Trick
John Innes Centre, Norwich Research Park, Colney, Norwich, NR4 7UH, UK
BMC Plant Biol 9:50. 2009The Brassica species include an important group of crops and provide opportunities for studying the evolutionary consequences of polyploidy...
- The dominance of alleles controlling self-incompatibility in Brassica pollen is regulated at the RNA levelHiroshi Shiba
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630 0101, Japan
Plant Cell 14:491-504. 2002Self-incompatibility (SI) in Brassica is controlled sporophytically by the multiallelic S-locus...
- Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamilySubhendu Mukherjee
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 1110, USA
J Agric Food Chem 56:609-17. 2008....
- High-density Brassica oleracea linkage map: identification of useful new linkagesMuqiang Gao
Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546, USA
Theor Appl Genet 115:277-87. 2007We constructed a 1,257-marker, high-density genetic map of Brassica oleracea spanning 703 cM in nine linkage groups, designated LG1-LG9...
- Migrant studies aid the search for factors linked to breast cancer riskNancy J Nelson
J Natl Cancer Inst 98:436-8. 2006
- Endocytosis and endosomal regulation of the S-receptor kinase during the self-incompatibility response in Brassica oleraceaRumen Ivanov
Reproduction et Developpement des Plantes, Institut Fédératif de Recherche 128, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Claude Bernard Lyon I, Ecole Normale Superieure de Lyon, F 69364 Lyon, France
Plant Cell 21:2107-17. 2009..There are, however, signaling phenomena that add a further layer of complexity. In the Brassica self-incompatibility response, a single cell can adequately respond to two opposite stimuli: accepting cross-..
- Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humansAkinori Yanaka
Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba ken, Tokyo, Japan
Cancer Prev Res (Phila) 2:353-60. 2009..pylori colonization in mice and improves the sequelae of infection in infected mice and in humans. This treatment seems to enhance chemoprotection of the gastric mucosa against H. pylori-induced oxidative stress...
- Analysis of the xylem sap proteome of Brassica oleracea reveals a high content in secreted proteinsLaetitia Ligat
Universite de Toulouse, UPS, UMR, Surfaces Cellulaires et Signalisation chez les Végétaux, Castanet Tolosan, France
Proteomics 11:1798-813. 2011..Here, we studied the proteome of Brassica oleracea cv Bartolo and compared it to the plant cell wall proteome of another Brassicaceae, the model plant ..
- Cold-activation of Brassica napus BN115 promoter is mediated by structural changes in membranes and cytoskeleton, and requires Ca2+ influxV Sangwan
Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec H3A 1B1, Canada
Plant J 27:1-12. 2001..Here we examine cold signaling in transgenic Brassica napus seedlings carrying, in addition to the endogenous cold-inducible BN115 gene, the beta-glucuronidase (GUS) ..
- Epigenetic chromatin modifications in Brassica genomesAgnieszka Braszewska-Zalewska
Department of Plant Anatomy and Cytology, University of Silesia, Jagiellonska 28, Katowice, Poland
Genome 53:203-10. 2010..b>Brassica species represent a very attractive model for analysis of epigenetic changes because of their differences in ..
- Functional alleles of the flowering time regulator FRIGIDA in the Brassica oleracea genomeJudith A Irwin
Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
BMC Plant Biol 12:21. 2012..The aim of this study was to identify and characterize orthologues of FRI in Brassica oleracea.
- Structural and transcriptional comparative analysis of the S locus regions in two self-incompatible Brassica napus linesY Cui
Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Plant Cell 11:2217-31. 1999Self-incompatibility (SI) in Brassica is controlled by a single locus, termed the S locus...
- UV-B irradiation changes specifically the secondary metabolite profile in broccoli sprouts: induced signaling overlaps with defense response to biotic stressorsInga Mewis
Leibniz Institute of Vegetable and Ornamental Crops Großbeeren Erfurt e V, Department of Quality, Theodor Echtermeyer Weg 1, D 14979 Großbeeren, Germany
Plant Cell Physiol 53:1546-60. 2012..3-1 kJ m(-2) d(-1)) were applied to sprouts of the important vegetable crop Brassica oleracea var...
- Effectiveness of edible coatings combined with mild heat shocks on microbial spoilage and sensory quality of fresh cut broccoli (Brassica oleracea L.)María Del R Moreira
Grupo de Investigación en Ingeniería de Alimentos Fac de Ingeniería, UNMDP, Juan B Justo 4302, 7600, Mar del Plata, Argentina
J Food Sci 76:M367-74. 2011....
- Brassica orthologs from BANYULS belong to a small multigene family, which is involved in procyanidin accumulation in the seedBathilde Auger
UMR118 Amélioration des Plantes et Biotechnologies Végétales, INRA, Agrocampus Ouest, Université Rennes1, Le Rheu Cedex, France
Planta 230:1167-83. 2009As part of a research programme focused on flavonoid biosynthesis in the seed coat of Brassica napus L. (oilseed rape), orthologs of the BANYULS gene that encoded anthocyanidin reductase were cloned in B...
- Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinaseVincent Vanoosthuyse
Reproduction et Developpement des Plantes, Unite Mixte de Recherche 5667, Institut National de la Recherche Agronomique, Universite Claude Bernard Lyon, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Plant Physiol 133:919-29. 2003Recognition of self-pollen during the self-incompatibility response in Brassica oleracea is mediated by the binding of a secreted peptide (the S locus cysteine-rich protein) to the S locus receptor kinase (SRK), a member of the plant ..
- First isolation of an antifungal lipid transfer peptide from seeds of a Brassica speciesPeng Lin
Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Peptides 28:1514-9. 2007..sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris...
- Characterization of the SP11/SCR high-affinity binding site involved in self/nonself recognition in brassica self-incompatibilityHiroko Shimosato
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630 0192, Japan
Plant Cell 19:107-17. 2007In Brassica self-incompatibility, the recognition of self/nonself pollen grains, is controlled by the S-locus, which encodes three highly polymorphic proteins: S-locus receptor kinase (SRK), S-locus protein 11 (SP11; also designated S-..
- Towards the production of high levels of eicosapentaenoic acid in transgenic plants: the effects of different host species, genes and promotersBifang Cheng
Bioriginal Food and Science Corporation, 110 Gymnasium Place, Saskatoon, SK S7N 0W9, Canada
Transgenic Res 19:221-9. 2010..Zero-erucic acid Brassica carinata appeared to be an outstanding host species for EPA production, with EPA levels in transgenic seed of ..
- Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoliShikha Saha
Institute of Food Research, Norwich Research Park, Norwich, UK
Mol Nutr Food Res 56:1906-16. 2012..We compared the bioavailability and metabolism of sulforaphane from portions of lightly cooked fresh or frozen broccoli, and investigated the bioconversion of sulforaphane to erucin...
- Aphid resistance in Brassica crops: challenges, biotechnological progress and emerging possibilitiesVarnika Bhatia
National Research Centre on Plant Biotechnology, Indian Agricultural Research Institute Campus, New Delhi, India
Biotechnol Adv 29:879-88. 2011..The present review is an attempt to highlight the current status and possible avenues to develop aphid resistance in Brassicaceae crops...
- Indirect plant-mediated interactions among parasitoid larvaeErik H Poelman
Laboratory of Entomology, Wageningen University, P O Box 8031, 6700 EH Wageningen, The Netherlands
Ecol Lett 14:670-6. 2011..Our results show that temporally separated parasitoid larvae are involved in indirect plant-mediated interactions by a network of trophic and non-trophic relationships...
- A zinc-finger-family transcription factor, AbVf19, is required for the induction of a gene subset important for virulence in Alternaria brassicicolaAkhil Srivastava
Plant and Environmental Protection Sciences, University of Hawaii at Manoa, 3190 Maile Way, St John 317, Honolulu 96822, USA
Mol Plant Microbe Interact 25:443-52. 2012..This study demonstrated the existence and the importance of a transcription factor that regulates a suite of genes that are important for decomposing and utilizing plant material during the late stage of plant infection...
- BraSto, a Stowaway MITE from Brassica: recently active copies preferentially accumulate in the gene spaceVéronique Sarilar
AgroParisTech CNRS, UMR 0320 UMR 8120 Génétique Végétale INRA Univ Paris Sud CNRS AgroParisTech, Ferme du Moulon, 91190, Gif sur Yvette, France
Plant Mol Biol 77:59-75. 2011We characterized a Brassica miniature inverted repeat transposable element (MITE) from the Stowaway superfamily, designated BraSto (Bra ssica Sto waway)...
- Synthesis of a Brassica trigenomic allohexaploid (B. carinata × B. rapa) de novo and its stability in subsequent generationsEntang Tian
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 1 Shizishan, 430070, Wuhan, China
Theor Appl Genet 121:1431-40. 2010..The present investigation was aimed at synthesising the first known chromosomally stable hexaploid Brassica with the genome constitution AABBCC...
- Parasitoid-specific induction of plant responses to parasitized herbivores affects colonization by subsequent herbivoresErik H Poelman
Laboratory of Entomology, Wageningen University, 6700 EH, Wageningen, The Netherlands
Proc Natl Acad Sci U S A 108:19647-52. 2011..Here, we show that the species identity of a parasitoid had a more significant effect on defense responses of Brassica oleracea plants than the species identity of the herbivorous hosts of the parasitoids. Consequently, B...
- Influence of feeding and oviposition by phytophagous pentatomids on photosynthesis of herbaceous plantsVioleta Velikova
Bulgarian Academy of Sciences, Institute of Plant Physiology, Acad G Bonchev Str, Bl 21, Sofia 1113, Bulgaria
J Chem Ecol 36:629-41. 2010..bugs, Murgantia histrionica and Nezara viridula (Heteroptera: Pentatomidae), affect photosynthetic parameters of Brassica oleracea (savoy cabbage) and Phaseolus vulgaris (French bean)...
- Fine mapping of loci involved with glucosinolate biosynthesis in oilseed mustard (Brassica juncea) using genomic information from allied speciesN C Bisht
Centre for Genetic Manipulation of Crop Plants, Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110 021, India
Theor Appl Genet 118:413-21. 2009..Based on the DNA sequences from Arabidopsis and Brassica oleracea for the different genes involved in the aliphatic glucosinolate biosynthesis, candidate genes were ..
- Growing hardier crops for better health: Salinity tolerance and the nutritional value of broccoliCarmen López-Berenguer
Food Science and Technology Department and Plant Nutrition Department, CEBAS CSIC, Espinardo, Murcia, Spain
J Agric Food Chem 57:572-78. 2009..Overall, the nutritional quality of the edible florets of broccoli was improved under moderate saline stress...
- Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen speciesCarla Sousa
REQUIMTE Servico de Farmacognosia, Faculdade de Farmacia, Universidade do Porto, R Anibal Cunha Porto, Portugal
J Agric Food Chem 56:4205-11. 2008The ability of tronchuda cabbage ( Brassica oleracea L. var. costata DC) to act as a scavenger of the reactive nitrogen species nitric oxide and peroxynitrite was investigated...
- Intra- and intergenomic homology of B-genome chromosomes in trigenomic combinations of the cultivated Brassica species revealed by GISH analysisXian Hong Ge
National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding Technology, National Center of Oil Crop Improvement Wuhan, Huazhong Agricultural University, Wuhan, 430070, PR China
Chromosome Res 15:849-61. 2007Intragenomic chromosome homology in the B genome of Brassica nigra and their homoeology with the chromosomes of the A-genome of B. rapa and C-genome of B...
- BcMF9, a novel polygalacturonase gene, is required for both Brassica campestris intine and exine formationLi Huang
Laboratory of Cell and Molecular Biology, Institute of Vegetable Science, Zhejiang University, Hangzhou 310029, China
Ann Bot 104:1339-51. 2009..role that the PG gene has played in pollen development and about this family in general, one putative PG gene, Brassica campestris Male Fertility 9 (BcMF9), was isolated from Chinese cabbage (Brassica campestris ssp. chinensis, syn...
- Characterization of 1-aminocyclopropane-1-carboxylate (ACC) deaminase containing Methylobacterium oryzae and interactions with auxins and ACC regulation of ethylene in canola (Brassica campestris)Munusamy Madhaiyan
Department of Agricultural Chemistry, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
Planta 226:867-76. 2007..role of 1-aminocyclopropane-1-carboxylate (ACC) deaminase containing bacteria on ethylene production in canola (Brassica campestris) in the presence of inhibitory concentrations of growth regulators were investigated...
- Ontogenetic changes of 2-propenyl and 3-indolylmethyl glucosinolates in Brassica carinata leaves as affected by water supplyMonika Schreiner
Department of Quality Research, Leibniz Institute of Vegetable and Ornamental Crops Grossbeeren and Erfurt e V, Theodor Echtermeyer Weg 1, Grossbeeren, Germany
J Agric Food Chem 57:7259-63. 2009Concentrations of 2-propenyl and 3-indolylmethyl glucosinolates in two lines of Brassica carinata (Holeta-1 and 37-A) were assessed during the vegetative life cycle under optimal or drought-inducing water supply conditions...
- The Fus3/Kss1 MAP kinase homolog Amk1 regulates the expression of genes encoding hydrolytic enzymes in Alternaria brassicicolaYangrae Cho
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Fungal Genet Biol 44:543-53. 2007..the Amk1 MAP kinase gene, a homolog of the Fus3/Kss1 MAP kinases in Saccharomyces cerevisiae, in the necrotrophic Brassica pathogen, Alternaria brassicicola. The amk1 disruption mutants showed null pathogenicity on intact host plants...
- Factors affecting the glucosinolate content of kale (Brassica oleracea acephala group)Pablo Velasco
Department of Plant Genetics, Mision Biologica de Galicia, Spanish Council for Scientific Research CSIC, Apartado 28, E 36080 Pontevedra, Spain
J Agric Food Chem 55:955-62. 2007Kales (Brassica oleracea acephala group) are important vegetable crops in traditional farming systems in the Iberian Peninsula. They are grown throughout the year to harvest their leaves and flower buds...
- Responses of Brassica oleracea cultivars to infestation by the aphid Brevicoryne brassicae: an ecological and molecular approachColette Broekgaarden
Plant Research International, Wageningen University and Research Centre, Wageningen, The Netherlands
Plant Cell Environ 31:1592-605. 2008..we take such an approach to study the interaction between the aphid Brevicoryne brassicae and four white cabbage (Brassica oleracea var. capitata) cultivars...
- The presence of a Sar1 gene family in Brassica campestris that suppresses a yeast vesicular transport mutation Sec12-1W Y Kim
Department of Biochemistry, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Korea
Plant Mol Biol 33:1025-35. 1997Two new members (Bsar1a and Bsar1b) of the Sar1 gene family have been identified from a flower bud cDNA library of Brassica campestris and their functional characteristics were analyzed...
- Haplotype structure of the stigmatic self-incompatibility gene in natural populations of Arabidopsis lyrataDeborah Charlesworth
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom
Mol Biol Evol 20:1741-53. 2003..In A. lyrata, the SRK S-domain controls the pistil recognition specificity, as in self-incompatible Brassica species. In alleles from plants derived from natural A...
- Linear dominance relationship among four class-II S haplotypes in pollen is determined by the expression of SP11 in Brassica self-incompatibilityTomohiro Kakizaki
Faculty of Agriculture, Iwate University, Morioka, 020 8550 Japan
Plant Cell Physiol 44:70-5. 2003..The Brassica SI system is controlled sporophytically by multiple alleles at the single locus, S, and dominance relationships ..
- Glucosinolate polymorphism in wild cabbage (Brassica oleracea) influences the structure of herbivore communitiesErika L Newton
Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Tremough, Penryn, Cornwall, UK
Oecologia 160:63-76. 2009..b>Brassica oleracea (Brassicaceae) produces aliphatic glucosinolates, which break down into toxins when leaf tissue is ..
- Lipid-rich tapetosomes in Brassica tapetum are composed of oleosin-coated oil droplets and vesicles, both assembled in and then detached from the endoplasmic reticulumKai Hsieh
Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
Plant J 43:889-99. 2005..Here we report the biogenesis and structures of tapetosomes in Brassica. Immunofluorescence confocal microscopy revealed that during early anther development, the endoplasmic reticulum (..
- Ectopic expression of an annexin from Brassica juncea confers tolerance to abiotic and biotic stress treatments in transgenic tobaccoSravan Kumar Jami
Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, AP, India
Plant Physiol Biochem 46:1019-30. 2008..A full-length cDNA for a gene encoding an annexin protein was isolated and characterized from Brassica juncea (AnnBj1)...
- Identification of individual chromosomes and parental genomes in Brassica juncea using GISH and FISHJ Maluszynska
Department of Plant Anatomy and Cytology, University of Silesia, Katowice, Poland
Cytogenet Genome Res 109:310-4. 2005..nigra, B. oleracea, B. campestris) and three allotetraploid (B. carinata, B. juncea, B. napus) species of Brassica, known as the "U-triangle" are one of the best model systems for the study of polyploidy...
- Development of public immortal mapping populations, molecular markers and linkage maps for rapid cycling Brassica rapa and B. oleraceaFederico Luis Iniguez-Luy
Agri aquaculture Nutritional Genomic Center CGNA, Plant Biotechnology Unit UBP, INIA Carillanca, P O Box 58 D, Temuco, Chile
Theor Appl Genet 120:31-43. 2009..of immortal mapping populations of rapid cycling, self-compatible lines, molecular markers, and linkage maps for Brassica rapa and B. oleracea and make the data and germplasm available to the Brassica research community. The B...
- Forward and reverse genetics of rapid-cycling Brassica oleraceaEdward Himelblau
Department of Biology, California Polytechnic State University, San Luis Obispo, CA 93407, USA
Theor Appl Genet 118:953-61. 2009Seeds of rapid-cycling Brassica oleracea were mutagenized with the chemical mutagen, ethylmethane sulfonate. The reverse genetics technique, TILLING, was used on a sample population of 1,000 plants, to determine the mutation profile...
- Water extracts of Brassica oleracea var. costata potentiate paraquat toxicity to rat hepatocytes in vitroC Sousa
REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, 4099 030 Porto, Portugal
Toxicol In Vitro 23:1131-8. 2009....
- Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivoEun Ju Cho
Department of Food Science and Nutrition, and Research Institute of Ecology for the Elderly, Pusan National University, 30 Jangjeon dong, Geumjeong Gu, Busan 609 735, Korea
J Nutr Sci Vitaminol (Tokyo) 52:437-44. 2006..The present study demonstrates that the BuOH fraction has an antioxidative effect in vitro and it protects against oxidative stress induced by diabetes in an in vivo model...
- Cytogenetics and genome analysis in Brassica cropsRod J Snowdon
Department of Plant Breeding, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University, Heinrich Buff Ring 26 32, 35392, Giessen, Germany
Chromosome Res 15:85-95. 2007The genus Brassica contains a wide range of diploid and amphipolyploid species including some of the most important vegetable, condiment and oilseed crops worldwide...
- Effect of storage, processing and cooking on glucosinolate content of Brassica vegetablesLijiang Song
Disease Mechanisms and Therapeutic Research Group, Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
Food Chem Toxicol 45:216-24. 2007Epidemiological studies have shown that consumption of Brassica vegetables decrease the risk of cancer. These associations are linked to dietary intake of glucosinolates and their metabolism to cancer preventive isothiocyanates...
- Tri-trophic effects of inter- and intra-population variation in defence chemistry of wild cabbage (Brassica oleracea)Jeffrey A Harvey
Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands
Oecologia 166:421-31. 2011..KIM), Old Harry (OH) and Winspit (WIN)] and two cultivars [Stonehead (ST), and Cyrus (CYR)] of cabbage, Brassica oleracea...
- Multi-functional acetyl-CoA carboxylase from Brassica napus is encoded by a multi-gene family: indication for plastidic localization of at least one isoformW Schulte
Max Planck Institut fur Zuchtungsforschung, Cologne, Germany
Proc Natl Acad Sci U S A 94:3465-70. 1997Three genes coding for different multifunctional acetyl-CoA carboxylase (ACCase; EC 188.8.131.52) isoenzymes from Brassica napus were isolated and divided into two major classes according to structural features in their 5' regions: class I ..
- Microsatellites in Brassica unigenes: relative abundance, marker design, and use in comparative physical mapping and genome analysisSwarup K Parida
National Research Centre on Plant Biotechnology, Indian Agricultural Research Institute, New Delhi 110012, India
Genome 53:55-67. 2010..The present study was designed to assay the unigenes of Brassica napus and B...
- Large-scale cis-element detection by analysis of correlated expression and sequence conservation between Arabidopsis and Brassica oleraceaGeorg Haberer
Munich Information Center for Protein Sequences, Institute for Bioinformatics, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
Plant Physiol 142:1589-602. 2006..promoter sequences were identified by a bidirectional best blast hit strategy in genome survey sequences from Brassica oleracea...
- Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea)Anne C Kurilich
U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland 20705, USA
J Agric Food Chem 51:4877-83. 2003..This work describes a method for studying the bioavailability of nutrients from kale (Brassica oleracea var...
- Performance of generalist and specialist herbivores and their endoparasitoids differs on cultivated and wild Brassica populationsRieta Gols
Laboratory of Entomology, Plant Science Group, Wageningen University, Wageningen, The Netherlands
J Chem Ecol 34:132-43. 2008..herbivores and their endoparasitoids were compared when reared on a wild and cultivated population of cabbage, Brassica oleracea, and a recently established feral Brassica species...
- Naturally occurring indel variation in the Brassica nigra COL1 gene is associated with variation in flowering timeMarita Kruskopf Osterberg
Department of Plant Biology, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
Genetics 161:299-306. 2002Previous QTL mapping identified a Brassica nigra homolog to Arabidopsis thaliana CO as a candidate gene affecting flowering time in B. nigra. Transformation of an A. thaliana co mutant with two different alleles of the B...
- Development of an insect herbivore and its pupal parasitoid reflect differences in direct plant defenseJeffrey A Harvey
Department of Multitrophic Interactions, Netherlands Institute of Ecology, P O Box 40, 6666 Heteren, The Netherlands
J Chem Ecol 33:1556-69. 2007..Pteromalus puparum, when reared on three wild populations (Kimmeridge, Old Harry, Winspit) of cabbage, Brassica oleracea, and a Brussels sprout cultivar...
- Comparative analysis of the Brassica oleracea genetic map and the Arabidopsis thaliana genomeMalgorzata Kaczmarek
Institute of Plant Genetics, Polish Academy of Sciences, Strzeszynska 34, 60 479 Poznan, Poland
Genome 52:620-33. 2009We further investigated genome macrosynteny for Brassica species and Arabidopsis thaliana. This work aimed at comparative map construction for B. oleracea and A. thaliana chromosomes based on 160 known A...
- Self-incompatibility in the genus Arabidopsis: characterization of the S locus in the outcrossing A. lyrata and its autogamous relative A. thalianaM Kusaba
Department of Plant Biology, Cornell University, Ithaca, New York 14853, USA
Plant Cell 13:627-43. 2001..thaliana and is thought to have diverged from A. thaliana approximately 5 million years ago and from Brassica spp 15 to 20 million years ago. Analysis of two S (sterility) locus haplotypes demonstrates that the A...
- Comparative biochemical and transcriptional profiling of two contrasting varieties of Brassica juncea L. in response to arsenic exposure reveals mechanisms of stress perception and toleranceSudhakar Srivastava
Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
J Exp Bot 60:3419-31. 2009..an insight into these mechanisms, biochemical and transcriptional profiling of two contrasting genotypes of Brassica juncea was performed...
- The ecology of Bacillus thuringiensis on the Phylloplane: colonization from soil, plasmid transfer, and interaction with larvae of Pieris brassicaeM F Bizzarri
School of Science, University of Greenwich, Chatham Maritime, UK
Microb Ecol 56:133-9. 2008..when donor and recipient strains were sprayed in vegetative form onto leaves of clover and pak choi (Brassica campestris var. chinensis). The rate of transfer was about 0...
- Lung carcinogenesis: Chemoprevention by Indole-3-carbinolFekadu Kassie; Fiscal Year: 2013..We propose that indole-3-carbinol (I3C), a constituent of Brassica vegetables, inhibits 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice ..
- Chemopreventative properties of Medicinal and Food plants of the Lumbee TribeTRACIE LOCKLEAR; Fiscal Year: 2010..Ebenaceae), Hydrastis canadensis L. (Ranunculaceae), Prunella vulgaris L. (Lamiaceae), and Brassica oleracea (Brassicaceae)...
- Indolecarbinol target proteins and anti-cancer signaling in human melanoma cellsGary L Firestone; Fiscal Year: 2013DESCRIPTION (provided by applicant): Indole-3-carbinol (I3C), an indolecarbinol compound obtained from Brassica vegetables, such as broccoli, cabbage and Brussels sprouts, exhibits potent anti-proliferative properties in a wide range of ..
- In vivo effects of sulforaphane supplementation on normal human prostateDaniel W Lin; Fiscal Year: 2013..a novel in vivo human intervention model to understand the activities of sulforaphane (the bioactive compound in Brassica vegetables) in human prostate since these bioactive plant compounds are believed to be associated with prostate ..
- Mosquito Vector Control Using Bt Coupled to Seed Oil BodiesMohd Amir Abdullah; Fiscal Year: 2009..A phase II application is planned in which oleosin coupled Bti and BtB will be expressed in canola (Brassica napus). The Bti/BtB expressing canola seeds can be produced and milled into Bt-flour at relatively low cost...
- Engineering Enhanced Plants for Arsenic RemediationDavid Lee; Fiscal Year: 2009..for remediation due to its small size, the team will bioengineer a highbiomass, non-food variety of a row crop, Brassica napus, with the transgenes. In Phase I, Edenspace will confirm that the transgenic B...
- DNA Markers for Fast Plants to Teach Scientific ThinkingDOUGLAS L contact WENDELL; Fiscal Year: 2010..The specific materials that we will develop are DNA markers for Fast Plants (rapid cycling Brassica rapa) and a laboratory module called the Paternity Testing with Fast Plants Lab...
- Biosensors for Environmental ContaminantsMICHAEL BLAYLOCK; Fiscal Year: 2005..The project takes advantage of a recently-discovered metal responsive promoter element in Brassica juncea linked to the B anthocyanin regulatory gene...
- Genes, Hormones & Environment in an Ovarian Cancer ModelDaniel Cramer; Fiscal Year: 2007..cancer is associated with a variety of antioxidants including lycopene, carotene, ginkgo, and indoles from Brassica vegetables as well as anti-inflammatory agents...
- Effects of Brassica on Markers of Colon Cancer RiskJAY FOWKE; Fiscal Year: 2002..Humans are exposed to these agents primarily through consuming Brassica vegetables (e.g., broccoli), but it is unknown if greater Brassica consumed could affect colon cancer risk...
- BRASSICA CAMPESTRIS MITOCHONDRIAL DNA REPLICATION ORIGINBRENT NIELSEN; Fiscal Year: 1993..objective of this project is to understand and characterize the mechanism of mitochondrial DNA replication in Brassica campestris, a higher plant...
- ISOTHIOCYANATE EXCRETION, BRASSICA, AND BREAST CANCERJAY FOWKE; Fiscal Year: 2002Dietary factors play an important role in the etiology of breast cancer. Vegetables of the Brassica genus, such as broccoli and cabbage, contain isothiocyanates (ITC) which increase glutathione-S-transferase (GST) activity, leading to the ..
- Chemoprevention Through Activation of Estrogen Receptor Alpha-Induced SenescenceHarikrishna Nakshatri; Fiscal Year: 2007..Interestingly, brassica vegetable- derived che mo preventive agents such as phenethyl isothiocyanate (PEITC) activate Chk2, which may ..
- HOMOLOGOUS RECOMBINATION IN ARABIDOPSIS THALIANAEthan Signer; Fiscal Year: 1992..will focus primarily on the small crucifer Arabidopsis thaliana as a model system, and secondarily on the related brassica cauliflower (Brassica oleracea var. botrytis...
- SELENIUM ENRICHED PLANT MATERIAL FOR CHEMOPREVENTIONBurt Ensley; Fiscal Year: 2002..We will transfer these genes into Brassica juncea, the Indian mustard plants, to produce a commercially viable high Se-methylselenocysteine plant product...
- Hormone Status Postmenopause: Colonic Bacterial EffectsJohanna Lampe; Fiscal Year: 2003..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
- Breast and Bone Density: Impact of Colonic EnvironmentJohanna Lampe; Fiscal Year: 2006..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
- GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCESJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCEJohanna Lampe; Fiscal Year: 2002..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
- UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Human Gut Microflora Profiling for Population StudiesJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- Serum IGFs--Effects of a Soy Intervention in HumansJohanna Lampe; Fiscal Year: 2002..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
- DNA Damage: Fruit & Vegetable Effects in a Feeding TrialJohanna Lampe; Fiscal Year: 2005..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
- Glucuronidation in Humans--Genotypes and PhenotypesJohanna Lampe; Fiscal Year: 2004..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
- Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Identifying targets for diagnosing oral candidiasisDavid Schofield; Fiscal Year: 2005..Since Candida species are the most important fungal pathogen of the oral cavity, the rapid and accurate diagnosis of oral candidiasis using novel disease biomarkers will significantly improve oral health. ..
- Chemopreventive Efficacy of Broccoli Sprouts in HumansThomas Kensler; Fiscal Year: 2004..abstract_text> ..
- Protection by Induction of Ubiquitin-Proteasome SystemsThomas Kensler; Fiscal Year: 2005....
- Gene-Nutrient Interactions and Breast CancerSUSAN STECK; Fiscal Year: 2007..abstract_text> ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- GENES, ANTICARCINOGENS AND COLON NEOPLASMSHenry Lin; Fiscal Year: 2006..Results may lead to better understanding of protective mechanisms involving aspirin and nonsteroidal anti-inflammatory drugs. ..
- Functional Status and the Menopause TransitionMaryFran R Sowers; Fiscal Year: 2010..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
- Third International Conference on Quantitative GeneticsBruce Weir; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Hormones, hormone-related genes, and colorectal cancerJennifer Lin; Fiscal Year: 2008..Findings from the proposed study of estrogen and progesterone will enhance our understanding of these lifestyle and genetic factors in relation to colorectal carcinogenesis. ..
- Change in Bone, Arthritis, Function: Hormones & ObesityMaryFran Sowers; Fiscal Year: 2009....
- Intake Promoting Effects of Large Portions in ChildrenJennifer Fisher; Fiscal Year: 2009..Finally, findings will provide a scientific basis for anticipatory guidance to parents of young children regarding appropriate portion size. ..
- Phytochemicals and estrogen-enhanced cancersKaren Auborn; Fiscal Year: 2006..We will use gene chip technology to look for induction or repression of other genes involved in apoptosis and cell cycle progression. ..
- Self recognition and signaling in plant reproductionJUNE NASRALLAH; Fiscal Year: 2005..abstract_text> ..
- Topoisomerases: Target for Antitrypanosomal TherapyTheresa Shapiro; Fiscal Year: 2006..Compounds that appear most promising will be evaluated in mice. These studies take a multi-faceted, rational, and tangible approach to the development of much-needed new anti-trypanosomal chemotherapy. ..
- Cohort Study of Risks for Benign Prostatic HyperplasiaAlan Kristal; Fiscal Year: 2005..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- Isothiocyanates in the Chemoprevention of Bladder CancerYuesheng Zhang; Fiscal Year: 2007..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- Inhibition of Macrophage Innate Immunity in TuberculosisWILLIAM NAUSEEF; Fiscal Year: 2007..unreadable] [unreadable]..
- ALCOHOL EFFECT ON HUMAN LACTATION AND INFANT BEHAVIORJULIE MENNELLA; Fiscal Year: 2007..AIM 3: To explore the role of early experiences with ethanol in mothers' milk and the emotional context of such experiences, on the recognition of, and preference for, the sensory properties of ethanol ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- Chronic Ingestion of Lutein and Zeaxanthin in PrimatesFrederick Khachik; Fiscal Year: 2003..Lutein/zeaxanthin supplements have widely used as a nutritional supplement un the U.S. since 1995, while safety and efficacy of these carotenoids has not yet been established. ..
- Effect of Selenoprotein SNPs on Prostate Cancer RiskMargaret Rayman; Fiscal Year: 2005..Reduction of cancer incidence in these sub-groups would reduce the incidence of prostate cancer in the population. ..
- Phospholipase D and the Actin CytoskeletonDAVID KUSNER; Fiscal Year: 2005..These studies will further both our specific knowledge of signal transduction mechanisms that regulate inflammation as well as our more general understanding of the spatial and temporal determinants of cellular activation and motility. ..
- Attenuation of Estrogen-Induced Cell ProliferationDOUGLAS WENDELL; Fiscal Year: 2003..Aim #2 is to test the hypothesis that the BN allele of Edpm3 attenuates a component of paracrine growth control. Aim #3 is to identify growth regulatory factors whose estrogen-dependent expression is affected by Edpm3 genotype. ..
- Estrogen, Metabolism, Menopause, and Health OutcomesMaryFran Sowers; Fiscal Year: 2006..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- Phytochemicals, ER-Stress and Prostate CancerKaren Auborn; Fiscal Year: 2007..Moreover, combinations of nutrients may work together and at lower concentrations to target cancer cells. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- Genetic mapping of a locus that regulates VEGF expression in a tumor modelDOUGLAS WENDELL; Fiscal Year: 2006..The mapping of SEV is the first essential step in the process of discovering how SEV controls VEGF expression. [unreadable] [unreadable] [unreadable]..
- SWAN Sleep Study II - Michigan CenterMaryFran Sowers; Fiscal Year: 2008..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
- Targeting Akt/NF-kappa beta for Pancreatic Cancer TherapyFazlul Sarkar; Fiscal Year: 2007..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
- An Exploratory Center for Obesity Research (RMI)Adam Drewnowski; Fiscal Year: 2006..By promoting interagency collaborations, these efforts will help the NIH develop a roadmap on how to effectively translate research findings into national, state, and local health policy. [unreadable] [unreadable]..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..