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Genomes and Genes | mucorSummarySummary: A genus of zygomycetous fungi of the family Mucoraceae, order Mucorales. It is primarily saprophytic, but may cause MUCORMYCOSIS in man from spores germinating in the lungs. Top Publications
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Publications
Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpinaJ P Wynn
Centre for Advanced Lipid Research, Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
Microbiology 147:2857-64. 2001The biochemical events associated with the onset of lipid accumulation in Mucor circinelloides and Mortierella alpina, under conditions of nitrogen-limited growth, have been elucidated; they differ in key aspects from those described in ..
Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulationYing Zhang
Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
Microbiology 153:2013-25. 2007..The genes encoding the isoform of ME involved in fatty acid synthesis were identified in Mucor circinelloides and Mortierella alpina, two commercially useful oil-producing fungi, using degenerate primers...
A pre-genetic study of the isoforms of malic enzyme associated with lipid accumulation in Mucor circinelloidesY Song
Centre for Advanced Lipid Research, Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
Microbiology 147:1507-15. 2001The oleaginous fungus Mucor circinelloides possesses at least six isoforms of malic enzyme (EC 1.1.1.40), a key lipogenic enzyme in filamentous fungi...
Fed-batch cultivation of Mucor indicus in dilute-acid lignocellulosic hydrolyzate for ethanol productionKeikhosro Karimi
Department of Chemical Engineering and Environmental Science, Chalmers University of Technology, 412 96, , Sweden
Biotechnol Lett 27:1395-400. 2005b>Mucor indicus fermented dilute-acid lignocellulosic hydrolyzates to ethanol in fed-batch cultivation with complete hexose utilization and partial uptake of xylose. The fungus was tolerant to the inhibitors present in the hydrolyzates...
Molecular cloning of Mucor hiemalis endo-beta-N-acetylglucosaminidase and some properties of the recombinant enzymeKiyotaka Fujita
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
Arch Biochem Biophys 432:41-9. 2004Endo-M, endo-beta-N-acetylglucosaminidase from Mucor hiemalis, is known as a useful enzyme for the synthesis of neoglycopeptides due to its transglycosylation activity...
Morphological changes of the filamentous fungus Mucor mucedo and inhibition of chitin synthase activity induced by anetholeMasahiro Yutani
Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
Phytother Res 25:1707-13. 2011..Anethole demonstrated antifungal activity against the filamentous fungus, Mucor mucedo IFO 7684, accompanied by hyphal morphological changes such as swollen hyphae at the tips...
A multicopy vector system for genetic studies in Mucor circinelloides and other zygomycetesK F Appel
Department of Fungal Biotechnology, Biotechnological Institute, , DK-2970, , Denmark
Mol Genet Genomics 271:595-602. 2004Transformation of Mucor circinelloides is routinely achieved by using a plasmid containing the wild-type leuA gene to complement the leucine requirement of an auxotrophic host strain...
Biotransformation using Mucor rouxii for the production of oleanolic acid derivatives and their antimicrobial activity against oral pathogensClarissa S Capel
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Café, S N, Ribeirao Preto, SP, 14040 903, Brazil
J Ind Microbiol Biotechnol 38:1493-8. 2011The goal of this study is to produce oleanolic acid derivatives by biotransformation process using Mucor rouxii and evaluate their antimicrobial activity against oral pathogens...
Transformation of Mucor miehei results in plasmid deletion and phenotypic instabilityAurelia Monfort
, , Apartado de Correos 73, E-46100 Burjassot, Valencia, Spain
FEMS Microbiol Lett 224:101-6. 2003b>Mucor miehei transformants resistant to geneticin have been obtained by treatment of protoplasts with different plasmids and by Agrobacterium-mediated DNA transfer...
High reliability transformation of the basal fungus Mucor circinelloides by electroporationAdrián Gutiérrez
Departamento de Genética y Microbiología Unidad asociada al IQFR CSIC, Facultad de Biologia, Universidad de Murcia, 30071 Murcia, Spain
J Microbiol Methods 84:442-6. 2011Molecular approaches to study the biology of the zygomycete Mucor circinelloides depend mainly on the existence of a polyethylene glycol-based transformation method, which is one of the most efficient in zygomycete fungi...
Inactivation of Mucor plumbeus by the combined actions of chitinase and high hydrostatic pressureM Fenice
Dipartimento di Agrobiologia e Agrochimica, University of Tuscia, Viterbo, Italy
Int J Food Microbiol 52:109-13. 1999..and/or fungal chitinase in order to study the inhibition of germination and growth of the food spoiling mold Mucor plumbeus. Total fungal inhibition was obtained either at 4...
Comparison of phytase production on wheat bran and oilcakes in solid-state fermentation by Mucor racemosusKrishnan Roopesh
Biotechnology Division, Regional Research Laboratory, CSIR, Trivandrum 695 019, India
Bioresour Technol 97:506-11. 2006..made for phytase production using wheat bran (WB) and oilcakes as substrates in solid-state fermentation (SSF) by Mucor racemosus NRRL 1994. WB was also used as mixed substrate with oil cakes...
Cloning and characterization of a gene encoding a malic enzyme involved in anaerobic growth in Mucor circinelloidesYonghua Li
Centre for Lipid Research, University of Hull, Cottingham Road, Hull HU6 7RX, UK
Mycol Res 109:461-8. 2005A 3193 bp contiguous sequence has been cloned from the oleaginous fungus Mucor circinelloides, that contains a full-length gene encoding a putative NADP+: dependent malic enzyme (EC. 1.1.1.40)...
Alternative splicing produces two endoglucanases with one or two carbohydrate-binding modules in Mucor circinelloidesYuko Baba
Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5-3-1, Chiyoda, Sakado-shi, Saitama 350-0289, Japan
J Bacteriol 187:3045-51. 2005..In this study, two cDNAs homologous to the rce1 gene, designated the mce1 and mce2 cDNAs, were cloned from Mucor circinelloides, a member of the subdivision Zygomycota...
Morphology and physiology of the dimorphic fungus Mucor circinelloides (syn. M. racemosus) during anaerobic growthTina L Lübbehüsen
Center for Process Biotechnology, Building 223, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
Mycol Res 107:223-30. 2003The dimorphic Mucor circinelloides requires an anaerobic atmosphere and the presence of 30% CO2 to grow as a multipolar budding yeast, otherwise hyphal growth predominates...
Mucor rouxii Rho1 protein; characterization and possible role in polarized growthSilvia Argimon
Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, Piso 4, 1428, Buenos Aires, Argentina
Antonie Van Leeuwenhoek 91:237-51. 2007We have previously shown that protein kinase A of the medically important zygomycete Mucor rouxii participates in fungal morphology through cytoskeletal organization...
Production of phytase by Mucor racemosus in solid-state fermentationBarbara Bogar
Department of Agricultural Chemical Technology, Budapest University of Technology and Economics, 1111 Budapest, Gellert ter 4, Hungary
Biotechnol Prog 19:312-9. 2003Phytase production was studied by three Mucor and eight Rhizopus strains by solid-state fermentation (SSF) on three commonly used natural feed ingredients (canola meal, coconut oil cake, wheat bran)...
Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloidesFrancisco Esteban Nicolas
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
Nucleic Acids Res 38:5535-41. 2010..Here, we show that the basal fungus Mucor circinelloides produces new classes of esRNAs that map to exons and regulate the expression of many protein coding ..
Complementary mating types of Mucor circinelloides show electrophoretic karyotype heterogeneityJ M Diaz-Minguez
Departamento de Microbiologia y Genetica, Universidad de Salamanca, Spain
Curr Genet 36:383-9. 1999Electrophoretic karyotypes of ten strains of Mucor circinelloides f. lusitanicus were generated by contour-clamped homogeneous electric field (CHEF) gel-electrophoresis...
Orbital and cranial nerve presentations and sequelae are hallmarks of invasive fungal sinusitis caused by Mucor in contrast to AspergillusAvani P Ingley
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia
Am J Rhinol 22:155-8. 2008..Outcome differences have been found in patients with Mucor and Aspergillus...
Mutants defective in a Mucor circinelloides dicer-like gene are not compromised in siRNA silencing but display developmental defectsFrancisco E Nicolas
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia 30071 Murcia, Spain
Fungal Genet Biol 44:504-16. 2007..We have isolated a dicer-like gene (dcl-1) of Mucor circinelloides, the first gene of this family to be identified in zygomycetes...
Substrate specificity and preference of Delta6-desaturase of Mucor rouxiiSutthicha Na-Ranong
School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkuntien, Bangkok, Thailand
FEBS Lett 579:2744-8. 2005..expression in Saccharomyces cerevisiae, substrate specificity and preference of Delta(6)-desaturase of Mucor rouxii...
Two classes of small antisense RNAs in fungal RNA silencing triggered by non-integrative transgenesFrancisco E Nicolas
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia, 30071 Murcia, Spain
EMBO J 22:3983-91. 2003Transformation of Mucor circinelloides with self-replicative plasmids containing a wild-type copy of the carotenogenic gene carB causes silencing of the carB function in 3% of transformants...
Physical and chemical adsorption of Mucor javanicus lipase on SBA-15 mesoporous silica. Synthesis, structural characterization, and activity performanceAndrea Salis
Department of Chemical Sciences, University of Cagliari, S.S. 554 Bivio Sestu 09042 Monserrato (CA, Italy
Langmuir 21:5511-6. 2005..Immobilization by physical adsorption of a commercial lipase preparation from Mucor javanicus was performed at different pH values (pH 5-8)...
In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse modelQiu N Sun
Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Antimicrob Agents Chemother 46:2310-2. 2002..The in vitro MICs of posaconazole and itraconazole for the strains of Mucor spp. used in this study ranged from 0.125 to 8 microg/ml and 0.25 to 8 microg/ml, respectively...
Heterologous expression of astaxanthin biosynthesis genes in Mucor circinelloidesTamas Papp
Department of Microbiology, Faculty of Sciences, University of Szeged, P O Box 533, 6701, Szeged, Hungary
Appl Microbiol Biotechnol 69:526-31. 2006Most Mucor species accumulate beta-carotene as the main carotenoid. The crtW and crtZ astaxanthin biosynthesis genes from Agrobacterium aurantiacum were placed under the control of Mucor circinelloides expression signals...
A single dicer gene is required for efficient gene silencing associated with two classes of small antisense RNAs in Mucor circinelloidesJuan P de Haro
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia, 30100 Murcia, Spain
Eukaryot Cell 8:1486-97. 2009RNA silencing in the zygomycete Mucor circinelloides exhibits uncommon features, such as induction by self-replicative sense transgenes and the accumulation of two size classes of antisense small interfering RNAs (siRNAs)...
Cloning of glyceraldehyde-3-phosphate dehydrogenase-encoding genes in Mucor circinelloides (Syn. racemosus) and use of the gpd1 promoter for recombinant protein productionAnne Mette Wolff
Department of Fungal Biotechnology, Biotechnological Institute, , , DK-2970, Denmark
Fungal Genet Biol 35:21-9. 2002..gpd2, and gpd3) encoding glyceraldehyde-3-phosphate dehydrogenase were isolated from the dimorphic zygomycete Mucor circinelloides by PCR using degenerated primers...
Fungemia and cutaneous zygomycosis due to Mucor circinelloides in an intensive care unit patient: case report and review of literatureMurat Dizbay
Department of Infectious Diseases, Gazi University School of Medicine, Ankara, Turkey
Jpn J Infect Dis 62:146-8. 2009b>Mucor spp. are rarely pathogenic in healthy adults, but can cause fatal infections in patients with immuosuppression and diabetes mellitus. Documented mucor fungemia is a very rare condition in the literature...
Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activitiesMidori Umekawa
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
J Biol Chem 283:4469-79. 2008Endo-beta-N-acetylglucosaminidase from Mucor hiemalis (Endo-M), a family 85 glycoside hydrolase, acts on the beta1,4 linkage of N,N'-diacetylchitobiose moiety in the N-linked glycans of glycoproteins and catalyzes not only the hydrolysis ..
Purification and characterisation of an acid phosphatase with phytase activity from Mucor hiemalis WehmerA Boyce
Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
J Biotechnol 132:82-7. 2007An acid phosphatase with phytase activity, produced by Mucor hiemalis Wehmer, was purified to homogeneity by a combination of anion exchange, gel filtration and hydrophobic interaction chromatography...
Predictors of pulmonary zygomycosis versus invasive pulmonary aspergillosis in patients with cancerGeorgios Chamilos
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 41:60-6. 2005..CONCLUSIONS: PZ in immunocompromised patients with cancer could potentially be distinguished from IPA on the basis of clinical and radiological parameters; prospective validation is needed...
Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitroSusanne Perkhofer
Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
Antimicrob Agents Chemother 52:2636-8. 2008..The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed...
Antifungal activity of essential oils against filamentous fungi determined by broth microdilution and vapour contact methodsV Tullio
Department of Public Health and Microbiology, University of Turin, Turin, Italy
J Appl Microbiol 102:1544-50. 2007..The in vitro activity of some essential oils (EO) (thyme red, fennel, clove, pine, sage, lemon balm and lavender) against clinical and environmental fungal strains was determined...
Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequencesKazuhiro Aoki
Graduate School of Biostudies, Kyoto University, Oiwake cho, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
J Biol Chem 279:32028-34. 2004..A novel family of neutral glycosphingolipids (GSLs) was found in these fungi and isolated from Mucor hiemalis, which is a typical Zygomycetes species...
Phase II metabolites of etofesalamide in filamentous fungiHai-Hua Huang
Department of Pharmaceutical Microbiology, Shenyang Pharmaceutical University, Shenyang 110016, China
Acta Pharmacol Sin 26:893-6. 2005..CONCLUSION: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals...
Isolation, identification and antifungal susceptibility of lemon pathogenic and non pathogenic fungiMaría Cristina Maldonado
Instituto de Biotecnologia, Facultad de Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Tucuman, Argentina
Rev Iberoam Micol 22:57-9. 2005..flavus, Aspergillus clavatus, Geotrichum candidum, Rhizopus sp, Penicillium sp, Penicillium digitatum and Mucor sp were studied. All the tested strains were resistant to thiabendazole...
Molecular analysis of an NAD-dependent alcohol dehydrogenase from the zygomycete Mucor circinelloidesR A Rangel-Porras
, Universidad de Guanajuato, Noria Alta s/n Apartado Postal 187, 36000, Guanajuato,
Mol Genet Genomics 274:354-63. 2005..was detected mainly in the cytosol of aerobically cultured mycelium and in anaerobically grown yeast cells of Mucor circinelloides. ADH levels were about 2...
Stereoselectivity of the generation of 3-mercaptohexanal and 3-mercaptohexanol by lipase-catalyzed hydrolysis of 3-acetylthioestersHidehiko Wakabayashi
, , Am Forum 2, D-85350 Freising-Weihenstephan, Germany
J Agric Food Chem 51:4349-55. 2003..The sulfur-containing compounds investigated possess attractive odor properties, and only one of the enantiomers exhibits the pleasant citrus type note...
Gas-phase enzymatic esterification on immobilized lipases in MCM-41 molecular sievesEmerson Luis Pires
Department of Chemical Processes, School of Chemical Engineering, State University of Campinas, SP, Brazil
Appl Biochem Biotechnol 98:963-76. 2002....
Study of lipase-catalyzed hydrolysis of some monoterpene estersT Chatterjee
Department of Chemical Technology, University Colleges of Science and Technology, University of Calcutta, India
Can J Microbiol 47:397-403. 2001..geranyl, and terpenyl acetates by commercially available lipases of Candida rugosa, Rhizopus arrhizus, and Mucor miehei are presented...
Evidence for selective hydrolysis of aliphatic copolyesters induced by lipase catalysisPaola Rizzarelli
Istituto di Chimica e Tecnologia dei Polimeri, Consiglio Nazionale delle Ricerche, Viale A Doria 6, 95125 Catania, Italy
Biomacromolecules 5:433-44. 2004..P(BS-co-BA), with different composition, were synthesized and subjected to enzymatic hydrolysis by Lipase from Mucor miehei or from Rhizopus arrhizus...
A RING-finger photocarotenogenic repressor involved in asexual sporulation in Mucor circinelloidesFrancisco E Nicolas
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia Murcia, Spain
FEMS Microbiol Lett 280:81-8. 2008b>Mucor circinelloides responds to blue light by activating the biosynthesis of carotenoids and bending its sporangiophores towards the light source...
Cerebral zygomycosisC Sundaram
Department of Pathology, Nizam s Institute of Medical Sciences, Punjagutta, Hyderabad, India
Mycoses 48:396-407. 2005..Of these, ten were culture proven (Rhizopus oryzae in eight and Mucor in two); 30 were diagnosed as probable and 16 were diagnosed possible; mixed infections were seen in three ..
Contemporary treatment and outcomes of zygomycosis in a non-oncologic tertiary care centerCharles R Sims
Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas Houston Medical School, Houston, Texas 77030, USA
Arch Med Res 38:90-3. 2007..Zygomycosis is an emerging mycosis of increasing relevance. Limited data exist for outcomes with contemporary therapies...
Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosisAshraf S Ibrahim
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
J Infect Dis 198:1083-90. 2008....
Native-like tertiary structure in the Mucor miehei lipase molten globule state obtained at low pHSadaf Fatima
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
IUBMB Life 59:179-86. 2007Studies on the acid-induced denaturation of Mucor miehei lipase (E.C. 3.1.1...
Improvement in extraction and catalytic activity of Mucor javanicus lipase by modification of AOT reverse micelleMahabubur Rahman Talukder
Institute of Chemical and Engineering Sciences, Singapore, Singapore
Biotechnol J 2:1369-74. 2007..The modified AOT reverse micellar system was used to extract Mucor javanicus lipase from the aqueous phase to the reverse micellar phase...
Microbial transformations of alpha-santoninAthar Ata
Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9
Z Naturforsch C 59:209-14. 2004Fungal biotransformations of alpha-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC ..
Enzymatic synthesis of phosphocarnitine, phosphogabob and fosfomycinKe Wang
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China
Org Biomol Chem 1:3564-9. 2003..obtained from easily available diethyl 3-chloro-2-oxopropanephosphonates, followed by subsequent reduction, Mucor miehei lipase (IM) mediated resolution, amination and dealkylation...
Highly regioselective enzymatic synthesis of polymerizable derivatives of methyl shikimateChao Li
Department of Chemistry, Key Laboratory of Green Chemistry and Technology Ministry of Education, Sichuan University, Chengdu 610064, PR China
Bioorg Med Chem Lett 17:6687-90. 2007..Lipase acrylic resin from Candida antarctica (CAL-B) and immobilized lipase from Mucor miehei (MML) showed high regioselectivity toward the secondary hydroxyl of methyl shikimate, which presents three ..
Effect of media composition and in vitro activity of posaconazole, caspofungin and voriconazole against zygomycetesCristina Gil-Lamaignere
Department of Paediatrics III, Paediatric Pulmonology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany
J Antimicrob Chemother 55:1016-9. 2005..MICs evaluated in AM3 were lower than in RPMI 1640 medium or HR medium. CONCLUSIONS: The in vivo effect of posaconazole in zygomycosis needs further evaluation...
The fungal profile of otomycosis patients in Ilorin, NigeriaC Nwabuisi
Department of Medical Microbiology, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State
Niger J Med 10:124-6. 2001..76(54%) were positive for at least one organism. The isolates included: Aspergillus (63.2%), Candida (35.5%), and Mucor (0.7%). Further analysis showed that Candida species comprised C. albicans (18.4%), C. tropicalis (10.5%), and C...
Fungi, aflatoxins, fumonisin Bl and zearalenone contaminating sorghum-based traditional malt, wort and beer in BotswanaDavid O Nkwe
Department of Biological Sciences, University of Botswana, Gaborone
Mycopathologia 160:177-86. 2005..Rhizopus, Fusarium, Mucor, and Aspergillus were the most common genera isolated...
Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diolKhalid A El Sayed
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe 71209, USA
J Nat Prod 71:117-22. 2008..Biotransformation of 1 using Mucor ramannianus ATCC 9628 and Cunninghamella elegans ATCC 7929 afforded the known 10 S,11 S-epoxy analogue of 1 (4) as ..
Microbial transformation of isosteviol and bioactivities against the glucocorticoid/androgen response elementsShwu Fen Chang
Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taiwan, Republic of China
J Nat Prod 71:87-92. 2008Preparative-scale fermentation of isosteviol ( ent-16-oxobeyeran-19-oic acid) (1) with Mucor recurvatus MR 36, Absidia pseudocylindrospora ATCC 24169, and Aspergillus niger BCRC 32720 afforded nine known metabolites ( 2, 3, 5-10, and 14) ..
Development and application of an assay for uranyl complexation by fungal metabolites, including siderophoresJoanna C Renshaw
Centre for Radiochemistry Research, Department of Chemistry, The University of Manchester, Manchester M13 9PT, United Kingdom
Appl Environ Microbiol 69:3600-6. 2003..Three isolates were selected for further study and were identified as two Pencillium species and a Mucor species...
Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed productsJie Zhang
Division of Pharmacognostical Biotechnology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
Phytochemistry 68:2523-30. 2007Biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus AS 3.3450 gave 10 metabolites (2-10), of which 2-5 were previously known...
Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosusMin Ye
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, People s Republic of China
J Nat Prod 68:626-8. 2005..Two minor products were isolated from the culture broth of Mucor spinosus and were identified as 7beta,15alpha-dihydroxybufalin (6) and 5beta,7beta-dihydroxybufalin (7), ..
Microbial transformation of dehydrocostuslactone by Mucor polymorphosporusX-C Ma
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
J Asian Nat Prod Res 8:713-8. 2006Biotransformation of dehydrocostuslactone (1) by Mucor polymorphosporus yielded four compounds, and their structures were identified as 11alpha,13-dihydrodehydrocostuslactone (2), 3alpha-hydroxy-11alpha,13-dihydrodehydrocostuslactone (3),..
Structural determination of three new germacrane-type sesquiterpene alcohols from curdione by microbial transformationXiao Chi Ma
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, P R China
Magn Reson Chem 45:90-2. 2007..Among them, 4, 5 and 6 are new compounds...
Microbial metabolism of steviol and steviol-16alpha,17-epoxideLi Ming Yang
Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
Phytochemistry 68:562-70. 2007..Incubation of 2 with the microorganisms Bacillus megaterium ATCC 14581, Mucor recurvatus MR 36, and Aspergillus niger BCRC 32720 yielded one new metabolite, ent-7alpha,11beta,13-trihydroxykaur-..
Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosusYin Tian
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road #38, Beijing 100083, People's Republic of China
J Nat Prod 68:678-80. 2005Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3...
Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeusBraulio M Fraga
Instituto de Productos Naturales y Agrobiologia, PO Box 195, CSIC, 38206 La Laguna, Tenerife, Canary Islands, Spain
J Nat Prod 66:327-31. 2003The microbiological transformation of the diterpene epicandicandiol (1) with Mucor plumbeus gave foliol (3), sideritriol (5), and 7beta,16alpha,17,18-tetrahydroxy-ent-kaurane (7), while the incubation of candicandiol (2) gave 7alpha,..
The microbiological transformation of the diterpenes dehydroabietanol and teideadiol by Mucor plumbeusBraulio M Fraga
Instituto de Productos Naturales y Agrobiologia, CSIC, Avda Astrofísico F Sánchez 3, La Laguna, 38206 Tenerife, Canary Islands, Spain
Phytochemistry 63:663-8. 2003The microbiological transformation of dehydroabietanol (18-hydroxy-dehydroabietane) by Mucor plumbeus led to 2alpha,18-dihydroxy-abieta-8,11,13,15-tetraene, 2alpha,15-dihydroxy-dehydroabietanol, 2alpha-hydroxy-15-methoxy-dehydroabietanol,..
Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeusCarlos Areche
Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile
Magn Reson Chem 46:765-8. 2008..by microbial transformation of mulin-11,13-dien-20-oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus. The latter compound has not been previously identified in the genus Mucor...
Distinct white collar-1 genes control specific light responses in Mucor circinelloidesFatima Silva
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia, 30071 Murcia, Spain
Mol Microbiol 61:1023-37. 2006..The best-known light response in the fungus Mucor circinelloides is the biosynthesis of beta-carotene. Here, we show that M...
cigA, a light-inducible gene involved in vegetative growth in Mucor circinelloides is regulated by the carotenogenic repressor crgAMaría D Quiles-Rosillo
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia, 30071, Murcia, Spain
Fungal Genet Biol 38:122-32. 2003..target genes controlled by crgA, a negative regulator of the light-inducible carotenogenesis in the fungus Mucor circinelloides...
A novel fungal prenyl diphosphate synthase in the dimorphic zygomycete Mucor circinelloidesAntonio Velayos
, , Universidad de Salamanca, Edificio Departamental, Lab 301-2, Avenida Campo Charro s/n, 37007 Salamanca, Spain
Curr Genet 45:371-7. 2004Two Mucor circinelloides structural genes involved in isoprenoid biosynthesis were isolated and characterised. The isoA gene encodes a typical eukaryotic farnesyl diphosphate synthase (EC 2.5.1...
Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxiiSauvarat Khunyoshyeng
School of Bioresources and Technology, King Mongkut s University of Technology Thonburi, Bangkok, Thailand
Fungal Genet Biol 37:13-21. 2002..gamma-linolenic acid (C18:3), constituted the majority in the total fatty acid content (44%) of sporangiospores of Mucor rouxii...
Significance of fatty acid supplementation on profiles of cell growth, fatty acid, and gene expression of three desaturases in Mucor rouxiiSakda Khoomrung
Pilot Plant Development and Training Institute, King Mongkut s University of Technology Thonburi, Bangkhuntien, Bangkok, Thailand
Appl Microbiol Biotechnol 80:499-506. 2008..of gamma-linolenic acid (GLA), a nutritionally important polyunsaturated fatty acid, were implemented in Mucor rouxii by supplementation with exogenous fatty acids...
Characterization of the Mucor circinelloides life cycle by on-line image analysisT L Lübbehüsen
Center for Process Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Lyngby, Denmark
J Appl Microbiol 95:1152-60. 2003The life cycle of the dimorphic fungus Mucor circinelloides was studied in a temperature-controlled flow-through cell, which constitutes an ideal tool when following the development of individual cells, with a view to understanding the ..
[Activity of NAD-dependent isocitrate dehydrogenase, isocitrate lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of nitrogen supply]I S Mysiakina
Mikrobiologiia 77:453-9. 2008..and activity of the enzymes of the tricarboxylic acid cycle and the glyoxylate cycle were studied in the fungus Mucor circinelloides var...
Post-harvest fungal quality of selected chewing sticksE Etebu
Department of Biological Sciences, Plant Pathology Unit, Rivers State University of Science and Technology, Rivers State, Port Harcourt, Nigeria
Oral Dis 9:95-8. 2003..To study post-harvest fungal overgrowth on chewing sticks used for oral hygiene measures and role of disinfection...
Relationship between spore germination kinetics and lag time during growth of Mucor racemosusP Dantigny
Laboratoire de Microbiologie, UMR INRA 1082, ENS BANA, Dijon, France
Lett Appl Microbiol 35:395-8. 2002..This paper aims at establishing a relationship between the percentage of germinated spores and parameters easily available from visible development...
Ethanol-induced dimorphism and lipid composition changes in Mucor fragilis CCMI 142I Serrano
, Instituto Nacional de Engenharia e Tecnologia Industrial, , Lisboa, Portugal
Lett Appl Microbiol 33:89-93. 2001AIMS: To study the effect of ethanol on morphology, lipid production and fatty acid profile of Mucor fragilis CCMI 142 cultures. METHODS AND RESULTS: Cell inhibition in shake flask cultures due to alcohol toxicity grew linearly from 0...
An unusual case of anaphylaxis. Mold in pancake mixA T Bennett
Office of the Chief Medical Examiner Department of Pathology and Laboratory Medicine, Forensic Section Medical University of South Carolina, Charleston, USA
Am J Forensic Med Pathol 22:292-5. 2001..mix was analyzed and found to contain a total mold count of 700/g of mix as follows: Penicillium, Fusarium, Mucor, and Aspergillus...
Lycopene over-accumulation by disruption of the negative regulator gene crgA in Mucor circinelloidesFrancisco E Nicolás-Molina
Departamento de Genética y Microbiología, Facultad de Biologia, Universidad de Murcia, 30071, Murcia, Spain
Appl Microbiol Biotechnol 78:131-7. 2008..The crgA gene, a negative regulator of carotenogenesis, was disrupted in the Mucor circinelloides strain MU202, which lacks the lycopene cyclase activity and accumulates lycopene instead of beta-..
Induction of glutathione S-transferase in biofilms and germinating spores of Mucor hiemalis strain EH5 from cold sulfidic spring watersEnamul Hoque
GSF National Research Center for Environment and Health, Institute of Groundwater Ecology, Ingolstadter Landstr 1, Neuherberg, Germany
Appl Environ Microbiol 73:2697-707. 2007..to the occurrence and activation of GST and the GST activities of the aquatic fungal strains EH5 and EH7 of Mucor hiemalis isolated for the first time from such waters...
Investigation of fungal contamination in sheep and goat cheeses in southern ItalyM T Montagna
DIMIMP Sez Igiene, Universita degli Studi di Bari, Bari, Italy
Mycopathologia 158:245-9. 2004..9%), followed by Geotrichum spp. (7.3%), Aspergillus spp. (4.2%) and Mucor spp. (4.2%)...
[Sporangiospores of the fungus Mucor lusitanicus 12M: correlation between lipid composition, viability, and morphology of growth upon germination]N S Funtikova
Institute of Microbiology, Russian Academy of Sciences, pr 60 letiya Oktyabrya 7, k 2, Moscow, 117312 Russia
Mikrobiologiia 72:775-9. 2003We studied viability of sporangiospores from a surface culture of the fungus Mucor lusitanicus 12M grown on wheat bran...
[Dimorphism of the fungus Mucor lusitanicus 12M depends on the cultivation conditions of sporangiospores]N S Funtikova
Mikrobiologiia 73:851-3. 2004
[Detection of extracellular protease in Mucor species]Maria Helena Alves
Universidade de Sao Paulo USP, and NPCIAMB, Recife, and Coordenacão de Biologia, Universidade Estadual Vale do Acarau, Av da Universidade, 850 Betania, Sobral, CE, CEP 62040 370, Brazil
Rev Iberoam Micol 22:114-7. 2005..The species of genus Mucor are a group of fungal microbes with important biotechnological potential, which are responsible for production of ..
Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneumDang Ngoc Quang
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
J Nat Prod 69:1198-202. 2006..carneum from different geographic regions, but do not constitute major metabolites of more than 100 species of Xylariaceae. Their biological and chemotaxonomic significance is discussed...
Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegansIgor A Parshikov
Department of Medicinal Chemistry, University of Mississippi, University, Mississippi 38677-1848, USA
J Nat Prod 67:1595-7. 2004..The metabolites 2 and 4 retained an intact peroxide group and are therefore useful scaffolds for synthetic modification in the search for new antimalarial agents...
Ester synthesis catalyzed by Mucor miehei lipase immobilized on magnetic polysiloxane-polyvinyl alcohol particlesLaura M Bruno
, Rua Dra. Sara Mesquita, 2270, Pici, 60511-110, Fortaleza-CE, Brazil
Appl Biochem Biotechnol 113:189-99. 2004b>Mucor miehei lipase was immobilized on magnetic polysiloxane-polyvinyl alcohol particles by covalent binding with high activity recovered...
Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipaseFrancesca Cateni
Department of Pharmaceutical Sciences, University of Trieste, P zle Europa 1, 34127 Trieste, Italy
Bioorg Med Chem Lett 17:1971-8. 2007..The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains...
A novel hydrophilic support, CoFoam, for enzyme immobilizationP T Vasudevan
Department of Chemical Engineering, University of New Hampshire, Durham, NH 03824, USA
Biotechnol Lett 26:473-7. 2004Lipases from different sources (porcine pancreas, Mucor miehei and Candida antarctica B) were covalently immobilized on a hydrophilic polyurethane composite (CoFoam). Their hydrolytic activities assayed with tributyrin were 0.55, 2...
Zygomycetes in human diseaseJ A Ribes
Departments of Pathology and Laboratory Medicine and of Clinical Laboratory Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
Clin Microbiol Rev 13:236-301. 2000..other organisms are also associated with human infection, including Mucor, Rhizomucor, Absidia, Apophysomyces, Saksenaea, Cunninghamella, Cokeromyces, and Syncephalastrum spp...
Mechanical transmission of pathogenic organisms: the role of cockroachesY M Tatfeng
Lahor Public Health and Research Centre, Benin City, Edo State, Nigeria
J Vector Borne Dis 42:129-34. 2005..Cockroaches (Diploptera punctata) are basically tropical insects and will do their best to find a home that is both warm and moist. Their involvement in the transmission of tropical diseases is poorly investigated in Africa...
Influence of environmental factors on airborne fungi in houses of Santa Fe City, ArgentinaMaria de la Luz Z Basilico
Facultad de Ingenieria Quimica, Universidad Nacional del Litoral, Santiago del Estero 2829, 3000 Santa Fe República Argentina
Sci Total Environ 376:143-50. 2007..37%), Curvularia (3.50%), Acremonium (1.27%), Drechslera (1.26%), Penicillium (1.25%), Aspergillus (1.14%), Mucor (0.61%), Ulocladium (0.57%), Nigrospora (0.48%), Chrysosporium (0.42%) and yeast (3...
Diversity of microflora in the gut and casts of tropical composting earthworms reared on different substratesK Parthasarathi
Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalainagar 608 002, India
J Environ Biol 28:87-97. 2007..albicans and Cryptococcus neoformans) were totally digested. Certain species of fungi (Saksenae vasiformis, Mucor plumbeus, Cladosporium carrionii, C. herbacium, Alternaria sp...
Mycobiota and mycotoxins in bee pollen collected from different areas of SlovakiaMiroslava Kacaniova
Department of Microbiology, Slovak University of Agriculture, Nitra
J Environ Sci Health B 46:623-9. 2011..The most frequent isolates of microscopic fungi found in bee pollen samples of all prevalent species were Mucor mucedo (49 isolates), Alternaria alternata (40 isolates), Mucor hiemalis (40 isolates), Aspergillus fumigatus (33 ..
Effect of processing for saponin removal on fungal contamination of quinoa seeds (Chenopodium quinoa Willd.)Ursula Pappier
Laboratorio de Microbiología de Alimentos, Departamento de Quimica Organica, Area Química y Microbiología de Alimentos, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Int J Food Microbiol 125:153-7. 2008..Other genera, such as Eurotium, Fusarium, Phoma, Ulocladium, Mucor and Rhizopus were less frequently isolated...
Microbiological contamination with moulds in work environment in libraries and archive storage facilitiesKatarzyna Zielinska-Jankiewicz
Nofer Institute of Occupational Medicine, Department of Environmental Health Hazards, Sw Teresy 8, 91 348 Lodz, Poland
Ann Agric Environ Med 15:71-8. 2008..The species involved include Aspergillus, Penicillium, Geotrichum, Alternaria, Cladosporium, Mucor, Rhizopus, Trichoderma, Fusarium which are associated mostly with allergic response of different types...
Development of a novel PCR assay for the identification of the black yeast, Exophiala (Wangiella) dermatitidis from adult patients with cystic fibrosis (CF)Yuriko Nagano
Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, United Kingdom
J Cyst Fibros 7:576-80. 2008..Trichosporon sp., Aureobasidium pullulans, Fusarium sp., Mucor hiemalis, Bionectria ochroleuca, Gibberella pulicaris. Results demonstrated that only DNA from E...
In vitro susceptibility to fungicides by invertebrate-pathogenic and saprobic fungiChristian Luz
DMIPP, Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, CP 131, 74001 970 Goiania, GO, Brasil
Mycopathologia 164:39-47. 2007..Mortierella isabellina, Mucor plumbeus, Rhizopus arrhizus and Trichothecium roseum) originating mostly from tree-hole breeding sites of ..
Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in PolandAnna Gora
Department of Occupational Biohazards, Institute of Agricultural Medicine, ul Jaczewskiego 2, 20 950 Lublin, Poland
Ann Agric Environ Med 16:143-50. 2009..Fungi constituted 2.5-76.9% of the total microbial count. Among them, Penicillium spp., Mucor spp., Alternaria spp., Aspergillus niger, and Aspergillus spp. were found. The dust concentration ranged from 0...
Simultaneous detection and identification of Aspergillus and mucorales species in tissues collected from patients with fungal rhinosinusitisZuotao Zhao
First Hospital, Peking University, Beijing 100034, People s Republic of China
J Clin Microbiol 49:1501-7. 2011..fumigatus, A. flavus, A. niger, A. terreus, and A. nidulans) and seven Mucorales species (Mucor heimalis, Mucor racemosus, Mucor cercinelloidea, Rhizopus arrhizus, Rhizopus microsporus, Rhizomucor pusillus, and ..
Modelling the effect of ethanol on growth rate of food spoilage mouldsPhilippe Dantigny
Laboratoire de Microbiologie, UMR Universite de Bourgogne INRA 1232, ENS BANA, 1 Esplanade Erasme, F 21000 Dijon, France
Int J Food Microbiol 98:261-9. 2005..Aspergillus candidus, Aspergillus flavus, Aspergillus niger, Cladosporium cladosporioides, Eurotium herbariorum, Mucor circinelloides, Mucor racemosus, Paecilomyces variotii, Penicillium chrysogenum, Penicillium digitatum, Rhizopus ..
Diversity of root associated microorganisms of selected medicinal plants and influence of rhizomicroorganisms on the antimicrobial property of Coriandrum sativumS Tamilarasi
Department of Biotechnology, Dr R V Arts and Science College, Karamadai, Coimbatore 641 104, India
J Environ Biol 29:127-34. 2008..Among the fungal isolates Rhizopus was found to be higher in number followed by Aspergillus, Penicillium, Mucor and Fusarium. About 70.96% of the bacterial isolates were found to be nitrate reducers and 90...
Research Grants
- Iron Uptake and Mucormycosis PathogenesisAshraf S Ibrahim; Fiscal Year: 2010..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
- Iron Uptake and Mucormycosis PathogenesisAshraf Ibrahim; Fiscal Year: 2009..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
- Mortality in Transplant Patients with AspergillosisJohn Baddley; Fiscal Year: 2007....
- Novel Antifungal Strategies for Lethal MucormycosisAshraf Ibrahim; Fiscal Year: 2007..Finally, the results of the current studies will be crucial to prioritizing antifungal strategies and study design for possible future clinical trials of patients infected with this extraordinarily deadly disease. ..
- Risk Factors and Outcomes of Candidemia in ChildrenTheoklis Zaoutis; Fiscal Year: 2007....
- Treatment of Fungal Infections with ATAK CellsAshraf Ibrahim; Fiscal Year: 2004..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
- Iron Uptake and Mucormycosis PathogenesisAshraf Ibrahim; Fiscal Year: 2007..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
