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| histoplasmaSummarySummary: A mitosporic Onygenales fungal genus causing HISTOPLASMOSIS in humans and animals. Its single species is Histoplasma capsulatum which has two varieties: H. capsulatum var. capsulatum and H. capsulatum var. duboisii. Its teleomorph is AJELLOMYCES capsulatus. Top Publications
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RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulenceChad A Rappleye
Department of Molecular Microbiology, Campus Box 8230, Washington University, St Louis, MO 63110, USA
Mol Microbiol 53:153-65. 2004b>Histoplasma capsulatum is a fungal pathogen that causes respiratory and systemic disease by proliferating within macrophages...- Heat shock protein 60: identification of specific epitopes for binding to primary macrophagesChristiane Habich
German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University of Dusseldorf, D 40225 Dusseldorf, Germany
FEBS Lett 580:115-20. 2006..Analysis of different pro- and eukaryotic HSP60 species indicated that phylogenetically separate HSP60 species use different binding sites on primary macrophages... 
Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetesPriscila Costa Albuquerque
Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, RJ Brazil
Cell Microbiol 10:1695-710. 2008..In the present study, we examine whether the clinically important ascomycete Histoplasma capsulatum produce vesicles and utilized these structures to secrete macromolecules...- Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatumAllan J Guimaraes
Department of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
Infect Immun 77:1357-67. 2009..The fungus Histoplasma capsulatum displays an Hsp60 on its cell surface that is a key target of the cellular immune response during .. - Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptorChad A Rappleye
Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:1366-70. 2007..Here, we show that alpha-(1,3)-glucan is present in the outermost layer of the Histoplasma capsulatum yeast cell wall and contributes to pathogenesis by concealing immunostimulatory beta-glucans from .. - Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functionsAllan Jefferson Guimarães
Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
Infect Immun 79:918-27. 2011b>Histoplasma capsulatum can efficiently survive within macrophages, facilitating H. capsulatum translocation from the lung into the lymphatics and bloodstream. We have recently generated monoclonal antibodies (MAbs) to an H... - Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activityGeorge S Deepe
Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
Clin Infect Dis 41:S204-7. 2005..necrosis factor (TNF)-alpha is required for host defenses against a number of pathogenic microbes, including Histoplasma capsulatum... - Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatumAllan Jefferson Guimarães
Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
PLoS ONE 3:e3449. 2008Histoplasmosis, due to the intracellular fungus Histoplasma capsulatum, can be diagnosed by demonstrating the presence of antibodies specific to the immunodominant M antigen... - Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasiiJames A Fraser
Department of Molecular Genetics and Microbiology, 322 CARL Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
Eukaryot Cell 6:622-9. 2007..we extend this analysis to define the mating type locus of three dimorphic primary human fungal pathogens, Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii, using genomic analysis, direct sequencing, and .. - Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophagesKristin H Long
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560, USA
J Immunol 170:487-94. 2003b>Histoplasma capsulatum (Hc), is a facultative intracellular fungus that binds to CD11/CD18 receptors on macrophages (Mphi)... - The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatumEszter Lazar-Molnar
Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 105:2658-63. 2008..In this study, we examined the role of PD-1 in a mouse model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus... 
Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infectionCarlos Artério Sorgi
Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Universidade de Sao Paulo, Ribeirao Preto, Brazil
J Immunol 182:4025-35. 2009b>Histoplasma capsulatum (Hc) is a facultative, intracellular parasite of worldwide significance...- Utilization and cell-surface binding of hemin by Histoplasma capsulatumLisa Anne Agiato Foster
Biology Department, Trinity College, Hartford, CT 06109, USA
Can J Microbiol 48:437-42. 2002b>Histoplasma capsulatum, a dimorphic fungus capable of causing severe respiratory illness in immunocompromised individuals, resides in macrophages during mammalian infection... - Histoplasma capsulatum strain variation in both H antigen production and beta-glucosidase activity and overexpression of HAG1 from a telomeric linear plasmidK L Fisher
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Infect Immun 67:3312-6. 1999The H antigen of the dimorphic fungal pathogen Histoplasma capsulatum was first described over 40 years ago. It is a secreted glycoprotein that is immunogenic during infection... - Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonizationLena H Hwang
Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
PLoS Pathog 4:e1000044. 2008The macrophage is the primary host cell for the fungal pathogen Histoplasma capsulatum during mammalian infections, yet little is known about fungal genes required for intracellular replication in the host... - Molecular cloning and expression of hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatumG Minchiotti
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Biochim Biophys Acta 1131:103-7. 1992We have cloned a nucleotide sequence from Histoplasma capsulatum G222B corresponding to a heat inducible hsp82 gene, and determined its entire sequence and the flanking regions... - A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosisLivia Cristina Liporagi Lopes
Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Clin Vaccine Immunol 17:1155-8. 2010Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis... - Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethalityJessica A Edwards
Department of Microbiology, The Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
Infect Immun 79:3348-57. 2011..Using known virulence mutants of Francisella novicida and Histoplasma capsulatum, we confirmed the applicability of these host cells for the quantitative assessment of bacterial and .. - Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatumJoshua D Nosanchuk
Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
J Clin Invest 112:1164-75. 2003..A protective role for antibodies has not previously been described for host defense against the pathogenic fungus Histoplasma capsulatum (Hc). Mouse mAb's were generated from mice immunized with Hc yeast that binds the cell surface of Hc... - Secreted dipeptidyl peptidase IV activity in the dimorphic fungal pathogen Histoplasma capsulatumKendal G Cooper
Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA
Infect Immun 77:2447-54. 2009..We identified a secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific substrates... - Histoplasma capsulatum synthesizes melanin-like pigments in vitro and during mammalian infectionJoshua D Nosanchuk
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 70:5124-31. 2002..This study investigated whether the thermally dimorphic fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin or melanin-like compounds in vitro and during infection... - Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defensesMichael S Winters
Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
J Infect Dis 202:1136-45. 2010The fungal pathogen Histoplasma capsulatum evades the innate and adaptive immune responses and thrives within resting macrophages... - A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophagesLi Shi
Division of Infectious Diseases, Departments of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Eukaryot Cell 7:1109-17. 2008Monoclonal antibodies (MAbs) to a cell surface histone on Histoplasma capsulatum modify murine infection and decrease the growth of H. capsulatum within macrophages. Without the MAbs, H... - Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofunginDavid van Duin
Department of Medicine, Division of Infectious Diseases. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Antimicrob Agents Chemother 46:3394-400. 2002The fungal pathogens Cryptococcus neoformans and Histoplasma capsulatum produce melanin-like pigments in the presence of L-dopa in vitro and during mammalian infection... - Histoplasma capsulatum heat-shock 60 orchestrates the adaptation of the fungus to temperature stressAllan Jefferson Guimarães
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, United States of America
PLoS ONE 6:e14660. 2011..A 62 kDa Hsp (Hsp60) of Histoplasma capsulatum (Hc) is an immunodominant antigen and the major surface ligand to CR3 receptors on macrophages... - Immune response to early and late Histoplasma capsulatum infectionsG S Deepe
Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267 0560, USA
Curr Opin Microbiol 3:359-62. 2000Knowledge of the host response to the intracellular pathogenic fungus Histoplasma capsulatum has increased dramatically... - Cloning and analysis of mold-specific genes in the dimorphic fungus Histoplasma capsulatumX Tian
Biological Sciences Department, Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS 39406-5018, USA
Gene 275:107-14. 2001A critical feature in the pathogenesis of the respiratory pathogen Histoplasma capsulatum is the conversion from the mold form (found in soil) to the yeast form in the lungs of the host... - Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatumMeggan C Laskowski
Infectious Disease Division, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0560, USA
BMC Microbiol 10:49. 2010b>Histoplasma capsulatum is a pathogenic ascomycete fungus that rapidly loses mating ability in culture... - The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosisPatricia Gorocica
Departamento de Bioquimica, Instituto Nacional de Enfermedades Respiratorias, Mexico, DF, Mexico
Mem Inst Oswaldo Cruz 104:492-6. 2009b>Histoplasma capsulatum is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H... - Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosisG S Deepe
Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267-0560, USA
Infect Immun 69:3128-34. 2001We previously reported that immunization with H antigen from Histoplasma capsulatum did not protect mice against an intravenous challenge with yeasts... - Potential role for extracellular glutathione-dependent ferric reductase in utilization of environmental and host ferric compounds by Histoplasma capsulatumM M Timmerman
Department of Medical Microbiology and Immunology, Microbiology Doctoral Training Program, University of Wisconsin, Madison 53706, USA
Infect Immun 69:7671-8. 2001The mammalian host specifically limits iron during Histoplasma capsulatum infection, and fungal acquisition of iron is essential for productive infection. H... - Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatumGeorge S Deepe
Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
Infect Immun 70:3759-67. 2002Vaccination with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune response in mice. We explored the cellular and molecular requirements for the efficacy of recombinant Hsp60 in mice... - Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopesEkaterina Dadachova
Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
J Nucl Med 45:313-20. 2004..We compared the susceptibility of human pathogenic fungi Cryptococcus neoformans (CN) and Histoplasma capsulatum (HC) to external gamma-radiation and to the organism-specific mAbs 18B7 and 9C7, respectively, .. - Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucanA I Medeiros
Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
Inflamm Res 53:351-4. 2004..and eotaxin and in vivo migration in the peritoneal cavity model, in mice inoculated with live yeast forms of Histoplasma capsulatum or the beta-glucan cell wall component of this fungus, and the influence of a leukotriene .. - Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10George S Deepe
Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 171:5353-62. 2003We determined whether the absence of IL-10 in mice influenced protective and memory immunity to Histoplasma capsulatum. IL-10(-/-) mice cleared primary and secondary infection more rapidly than wild-type controls... - Interaction of Histoplasma capsulatum yeasts with galactosylated surface molecules of murine macrophagesEsperanza Duarte-Escalante
, Facultad de Medicina, , Mexico City, Mexico
Arch Med Res 34:176-83. 2003BACKGROUND: Histoplasma capsulatum (H.c.) yeast-cell binding to glycosylated surface molecules of murine macrophages was studied using attachment inhibition assays with different carbohydrate-treated H.c... - Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungsGeorge S Deepe
Veterans Affairs Hospital, Cincinnati, OH, USA
J Leukoc Biol 84:669-78. 2008Numerous in vitro studies have demonstrated that Histoplasma capsulatum is engulfed by the diverse populations of phagocytic cells including monocytes/macrophages (Mphi), immature dendritic cells (DC), and neutrophils... - Colonic coinfection of histoplasma and cytomegalovirus mimicking carcinoma in a patient with HIV/AIDSXinqing Fan
Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA
Gastrointest Endosc 67:977-8; discussion 978. 2008 - Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDSMaria Eugenia Gutierrez
Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama
Clin Vaccine Immunol 15:681-3. 2008..Whether infection with these Latin American genotypes produces positive results in the Histoplasma antigen assay has not been reported... - A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatumMark Scheckelhoff
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
Infect Immun 73:2129-34. 2005Immunization of mice with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein designated F3 confers protection. Vbeta8.1/8.2+ T cells are critically important for the protective efficacy of this antigen... - The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosisJeremy Hilty
Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Mol Microbiol 70:127-39. 2008b>Histoplasma capsulatum is a dimorphic fungal pathogen that survives and replicates within macrophages (Mphi)... - Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patientsPierre Loulergue
University Paris V, Paris, France
Emerg Infect Dis 13:1647-52. 2007African histoplasmosis caused by Histoplasma capsulatum var. duboisii is an invasive fungal infection endemic in central and west Africa. Most of its ecology and pathogenesis remain unknown. H. capsulatum var... - Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophilsSimon L Newman
Division of Infectious Diseases, University of Cincinnati College of Medicine, OH, USA
Methods Mol Med 118:181-91. 2005b>Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen indigenous to the Ohio and Mississippi River Valleys in the United States... - Histoplasma capsulatum yeast cells attach and agglutinate human erythrocytesM L Taylor
Department of Microbiología Parasitología, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Med Mycol 42:287-92. 2004The ability of yeast cells of Histoplasma capsulatum to attach and agglutinate human erythrocytes has been described. This is the first report involving these yeasts in the hemagglutination phenomenon... - Comparison of an established antibody sandwich method with an inhibition method of Histoplasma capsulatum antigen detectionT O Garringer
Departments of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Microbiol 38:2909-13. 2000The Histoplasma antigen immunoassay utilizes an antibody sandwich method that provides a rapid and reliable means of diagnosing the more severe forms of histoplasmosis... - The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouseJ A Mayfield
Department of Molecular and Cell Biology, The University of California Berkeley, Berkeley, CA 94720 3202, USA
Genes Immun 8:468-74. 2007The pathogenic fungus Histoplasma capsulatum causes disease ranging from mild to fatal in healthy and immunocompromised humans. Infection rates reach 80% in endemic areas, including the Midwestern United States... - Interaction of murine macrophage-membrane proteins with components of the pathogenic fungus Histoplasma capsulatumM L Taylor
Department of Microbiología Parasitología, Faculty of Medicine, UNAM, Mexico, DF, Mexico
Clin Exp Immunol 113:423-8. 1998The interaction of macrophage-membrane proteins and histoplasmin, a crude antigen of the pathogenic fungus Histoplasma capsulatum, was studied using murine peritoneal macrophages... - Expression and interstrain variability of the YPS3 gene of Histoplasma capsulatumMegan L Bohse
Department of Medical Microbiology and Immunology, 420 SMI, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
Eukaryot Cell 6:609-15. 2007The YPS3 locus of the dimorphic fungus Histoplasma capsulatum encodes a secreted and surface-localized protein specific to the pathogenic yeast phase. In this study we examined this locus in 32 H. capsulatum strains and variants... - Phenotypic variation and persistence of Histoplasma capsulatum yeasts in host cellsL G Eissenberg
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Infect Immun 64:5310-4. 1996Many Histoplasma capsulatum strains spontaneously give rise to variants during broth culture or subsequent to ingestion by epithelial cells... - Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeastsSimon L Newman
Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267 0560, USA
Med Mycol 49:356-64. 2011Infections due to Histoplasma capsulatum occur as a result of the inhalation of airborne microconidia of the mold into the alveoli of the lungs... - Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophagesJeremy Hilty
Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
Med Mycol 49:633-42. 2011b>Histoplasma capsulatum is a dimorphic fungal pathogen that survives and replicates within macrophages (MΦ). Studies in human and murine MΦ demonstrate that the intracellular growth of H... - Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatumEric D Holbrook
Departments of Microbiology and Internal Medicine, The Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio 43210, United States
J Proteome Res 10:1929-43. 2011The dimorphic fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease. Within the mammalian host, pathogenic Histoplasma yeast infect, replicate within, and ultimately kill host phagocytes... - Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infectionWendy A Szymczak
Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Infect Immun 78:2125-37. 2010Excessive production of interleukin-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2... - Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatumRachael Hanby Webster
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
Proc Natl Acad Sci U S A 105:14573-8. 2008The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentous form in the soil and, after inhalation of infectious spores, converts to a pathogenic yeast form inside host macrophages in response to temperature... - HistoplasmosisL Joseph Wheat
MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
Infect Dis Clin North Am 17:1-19, vii. 2003..This article provides an up-to-date clinical review of histoplasmosis, focusing on recognition, diagnosis, and management... - Identification of a copper-inducible promoter for use in ectopic expression in the fungal pathogen Histoplasma capsulatumDana Gebhart
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143-0414, USA
Eukaryot Cell 5:935-44. 2006Despite the existence of a number of genetic tools to study the fungal pathogen Histoplasma capsulatum, strategies for conditional gene expression have not been developed... - Performance characteristics of a polyclonal enzyme immunoassay for the quantitation of Histoplasma antigen in human urine samplesJoann L Cloud
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
Am J Clin Pathol 128:18-22. 2007An antigen detection assay was prepared with rabbit anti- Histoplasma antibodies to detect and quantitate Histoplasma capsulatum antigen in urine samples... - Rare homologous gene targeting in Histoplasma capsulatum: disruption of the URA5Hc gene by allelic replacementJ P Woods
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Bacteriol 180:5135-43. 1998..We cloned the Histoplasma capsulatum URA5 gene (URA5Hc) by using a probe generated by PCR with inosine-rich primers based on relatively .. - Phylogeography of the fungal pathogen Histoplasma capsulatumTakao Kasuga
Department of Plant and Microbial Biology, 321 Koshland Hall, University of California, Berkeley, CA 94720, USA
Mol Ecol 12:3383-401. 2003Until recently, Histoplasma capsulatum was believed to harbour three varieties, var. capsulatum (chiefly a New World human pathogen), var. duboisii (an African human pathogen) and var... - Identification of Histoplasma capsulatum transcripts induced in response to reactive nitrogen speciesM Paige Nittler
Department of Microbiology and Immunology, University of California-San Francisco, San Francisco, CA 94143-0414, USA
Mol Biol Cell 16:4792-813. 2005The pathogenic fungus Histoplasma capsulatum escapes innate immune defenses and colonizes host macrophages during infection... - [Dimorphism and pathogenesis of Histoplasma capsulatum]C E Lopez
Centro de Referencia de Micologia, Facultad de Ciencias Bioquimicas y Farmacdutica, Universidad Nacional de Rosario, Suipacha 531 2000 Rosario, Argentina
Rev Argent Microbiol 38:235-42. 2006..This paper presents an overall view of advances in the investigation of H. capsulatum dimorphic transition and pathogenesis... - Characterization of cerebrosides from the thermally dimorphic mycopathogen Histoplasma capsulatum: expression of 2-hydroxy fatty N-acyl (E)-Delta(3)-unsaturation correlates with the yeast-mycelium phase transitionM S Toledo
Department of Biochemistry, , Rua Botucatu 862, 04023-900, , SP, Brasil
Glycobiology 11:113-24. 2001..in neutral lipids extracted from both the yeast and mycelial forms of the thermally dimorphic mycopathogen Histoplasma capsulatum... - Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum DarlingT Kasuga
Roche Molecular Systems, Alameda, California 94501, USA
J Clin Microbiol 37:653-63. 1999The phylogeny of 46 geographically diverse Histoplasma capsulatum isolates representing the three varieties capsulatum, duboisii, and farciminosum was evaluated using partial DNA sequences of four protein coding genes... - Relatedness analyses of Histoplasma capsulatum isolates from Mexican patients with AIDS-associated histoplasmosis by using histoplasmin electrophoretic profiles and randomly amplified polymorphic DNA patternsM R Reyes-Montes
Departamento de Microbiología Parasitología, Facultad de Medicina, UNAM, Mexico City, Mexico
J Clin Microbiol 37:1404-8. 1999..histoplasmin electrophoretic profiles and the randomly amplified polymorphic DNA (RAPD) patterns of the fungus Histoplasma capsulatum isolated from Mexican patients with AIDS-associated histoplasmosis... - Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusionLucy A Gildea
Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, OH 45267, USA
Infect Immun 73:6803-11. 2005b>Histoplasma capsulatum is a fungal pathogen that requires the induction of cell-mediated immunity (CMI) for host survival. We have demonstrated that human dendritic cells (DC) phagocytose H... - Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patientsMaha A Assi
Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Medicine (Baltimore) 86:162-9. 2007..Of these, 78 patients had disseminated histoplasmosis and 55 patients had Histoplasma capsulatum fungemia. The mean age of patients was 55 years, 66% were male, and 98% were white... - Histoplasmosis as a cause for a positive Fungitell (1 --> 3)-beta-D-glucan testLindsey Egan
MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
Med Mycol 46:93-5. 2008..Therefore, there is a need to conduct confirmatory tests for histoplasmosis in the appropriate clinical setting... - [Histoplasmosis leading to diagnosis of HIV infection]Vincent Peigne
, , Paris
Presse Med 35:1849-50. 2006 - An outbreak of histoplasmosis in the city of Blumenau, Santa CatarinaFlávio de Mattos Oliveira
Santa Casa Hospital Mycology Laboratory, Porto Alegre, RS, Brazil
J Bras Pneumol 32:375-8. 2006..Isolation of Histoplasma capsulatum var. capsulatum from soil samples is conclusive evidence of an epidemic focus... - Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complexHumberto M Guiot
Division of Infectious Diseases, Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA
Diagn Microbiol Infect Dis 57:429-33. 2007..Although the diagnosis was established by histopathologic findings and a positive bone marrow culture, Histoplasma capsulatum-specific real-time Polymerase Chain Reaction (PCR) allowed to confirm the diagnosis from formalin-.. - Cutaneous cryptococcosis erroneously diagnosed as Histoplasma capsulatum infectionGeoffrey A Chipungu
Faculty of Sciences, University of Cape Town
S Afr Med J 98:85-6. 2008 - Disseminated histoplasmosis: case report and brief reviewAbdulrahman Doughan
Emory University School of Medicine, Cardiology, 1639 Pierce Dr Suite 319 WMB Atlanta, GA 30322, USA
Travel Med Infect Dis 4:332-5. 2006..We report our experience to increase awareness of the clinical spectrum of disseminated histoplasmosis and its similarity to other infections and malignancies and update the reader on recommended therapeutic modalities... - [Severe colitis due to Histoplasma capsulatum in an AIDS patient]T Buhk
, Hamburg
Z Gastroenterol 44:603-7. 2006..Histological examination of biopsies from coloscopy and blood cultures revealed Histoplasma capsulatum. The patient recovered completely following antifungal therapy with amphotericin B and itraconazole... - Chest pain resulting from histoplasmosis pericarditis: a brief report and review of the literatureJessica J Wang
UT Southwestern Medical Center at Dallas, Dallas, Texas 75390-9047, USA
Cardiol Rev 14:223-6. 2006..Finally, further clinical trials are needed to study the role of antifungal therapy in the treatment of histoplasmosis pericarditis... - [Disseminated histoplasmosis and AIDS. The role of culture medium for the bronchoscopic clinical specimens]Gisela Unis
, Porto Alegre, RS
Rev Soc Bras Med Trop 37:234-7. 2004..Sabouraud's chloramphenicol agar it was 20%, supporting the importance of selective medium in the isolation of Histoplasma capsulatum var capsulatum from potentially contaminated clinical specimens, as well as the importance of .. - Unusual manifestations of histoplasmosisGeorge Richard Thompson
Department of Internal Medicine, Division of Infectious Diseases, University of Missouri, Columbia, Missouri, USA
Diagn Microbiol Infect Dis 50:33-41. 2004We present 6 cases of infection with Histoplasma capsulatum that have been uncommonly or not previously reported. Our case reports include unusual manifestations of H... - Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassayChadi A Hage
Department of Medicine, Indiana University, 111P IU, Indianapolis, IN 46202, USA
Respir Med 101:43-7. 2007..was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83... - Histoplasmosis of the tibiaBryce A Palmgren
University of Kansas School of Medicine-Wichita, Wichita, Kan, USA
Orthopedics 28:67-8. 2005 - Disseminated cryptococcosis and histoplasmosis co-infection in a HIV-infected woman in FranceT Ferry
Service des Maladies Infectieuses et Tropicales, Hopital de la Croix Rousse, 103 Grande Rue de la Croix Rousse, 69317 Lyon Cedex 04, France
J Infect 51:e173-6. 2005..b>Histoplasma antigen detection is not yet available in France but it could have a key role in the early diagnosis of .. - Interdigital involvement in a case of primary cutaneous canine histoplasmosis in JapanK Nishifuji
Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582
J Vet Med A Physiol Pathol Clin Med 52:478-80. 2005..of fungal ribosome RNA gene isolated from a paraffin sample revealed a 100% homology with the teleomorph of Histoplasma capsulatum... - Histoplasmosis in a Brazilian center: clinical forms and laboratory testsBeatriz Consuelo Quinet Leimann
Departamento de Micro Imuno Parasitologia, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
Rev Iberoam Micol 22:141-6. 2005Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is endemic in many regions of the Americas, Asia and Africa... - A 43-year-old woman with acquired immunodeficiency syndrome and fever of undetermined origin. Disseminated histoplasmosisOsama M Al-Agha
Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
Arch Pathol Lab Med 130:120-3. 2006 - Histoplasmosis as cause of penile ulcer in acquired immune deficiency syndrome (AIDS): three case reportsEderson Valei Lopes de Oliveira
Medical School in São José do Rio Preto, Hospital de Base, Avenida Brigadeiro Faria Lima, n 5416, CEP 15090 000, Sao Jose do Rio Preto, SP, Brazil
Mycopathologia 164:295-9. 2007b>Histoplasma capsulatum is the causative agent of American histoplasmosis. The relationship between disseminated histoplasmosis and AIDS has been well established... - [Intestinal histoplasmosis in an HIV positive patient]Luis Trombetta
Medicina (B Aires) 67:521-2. 2007 - Redefining the clinical spectrum of chronic pulmonary histoplasmosis: a retrospective case series of 46 patientsCassie C Kennedy
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Medicine (Baltimore) 86:252-8. 2007Chronic pulmonary histoplasmosis is a disorder caused by Histoplasma capsulatum infection that is classically described as cavitary disease in male smokers with underlying chronic obstructive pulmonary disease (COPD)... - [Miliary cerebral Histoplasma capsulatum in an HIV-negative patient]C Blanchard
Service de Neurologie, hôpital d instruction des armées Clermont Tonnerre, Rue Fontferrier, 29240 Brest
Rev Neurol (Paris) 163:740-2. 2007..Despite itraconazole IV the patient died. This observation illustrates the difficulties in diagnosis and treatment of cerebral histoplasmosis and the various patterns of drug interactions... - Necrotizing pneumonia with a questionable lung mass in a 59-year-old manJaine Brownell
Department of Medicine, Division of Allergy and Immunology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 96:116-21. 2006 - Urine polymerase chain reaction is not as sensitive as urine antigen for the diagnosis of disseminated histoplasmosisYi Wei Tang
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Diagn Microbiol Infect Dis 54:283-7. 2006..a colorimetric microtiter plate polymerase chain reaction enzyme immunoassay (PCR-EIA) for the detection of Histoplasma capsulatum in urine. The specificity of the PCR assay was confirmed using H... - [Histoplasmosis (infection with Histoplasma capsulatum, capsulatum variety)]V Pădeanu
Spitalul de Pneumologie Baia Mare
Pneumologia 54:72-5. 2005..Diagnosis is based on evidence of mycotic filaments on microscopy or culture. Treatment consists of Amphotericin B and Itraconazole, the latter being also the foundation of primary and secondary prevention... - Disseminated histoplasmosis in acquired immunodeficiency syndrome patients in Uberaba, MG, BrazilDelio Jose Mora
Department of Infectious Diseases, Universidade Federal do Triangulo Mineiro, Uberaba, Minas Gerais, Brazil
Mycoses 51:136-40. 2008.... - [Hoarseness in a recent visitor to the tropics through infection of the larynx by Histoplasma capsulatum]L C Smeets
afd. Medische Microbiologie en Infectiepreventie, Jeroen Bosch Ziekenhuis, Postbus 90.153, 5200 ME's-Hertogenbosch
Ned Tijdschr Geneeskd 149:657-9. 2005..and a sore throat for the previous 3 months, which were caused by a laryngeal infection with the fungus Histoplasma capsulatum. He had been infected during a stay in Indonesia... - Test and teach. Number fifty-three. Diagnosis: HistoplasmosisMay K P Lee
Department of Microbiology, Prince of Wales Hospital, Chinese University of Hong Kong, SAR
Pathology 37:380-1, 382-3. 2005 - Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazoleL Joseph Wheat
MiraVista Diagnostics MiraBella Technologies, 4444 Decatur Boulevard, Indianapolis, IN 46241, USA
J Antimicrob Chemother 57:1235-9. 2006To determine the activity of newer triazoles against strains of Histoplasma capsulatum resistant to fluconazole. - Global control of dimorphism and virulence in fungiJulie C Nemecek
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Science 312:583-8. 2006..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease... - Histoplasma phimosis: an uncommon presentation of a not uncommon pathogenShashi M Ariyanayagam-Baksh
Department of Pathology, Lancaster General Hospital, Lancaster, PA 17604 3555, USA
Am J Dermatopathol 29:300-2. 2007Infection from Histoplasma capsulatum is usually subclinical, but it also can be disseminated in patients with a compromised immune status... - Drug-drug interaction between itraconazole and efavirenz in a patient with AIDS and disseminated histoplasmosisHoonmo L Koo
Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
Clin Infect Dis 45:e77-9. 2007..The drug combination resulted in persistently elevated urinary Histoplasma antigen levels and subtherapeutic plasma itraconazole concentrations... - Therapeutic monitoring is necessary for the association itraconazole and efavirenz in a patient with AIDS and disseminated histoplasmosisEstelle Huet
AIDS 22:1885-6. 2008 - Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samplesAndrea Bracca
, IBR-CONICET, , 2000 Rosario, Argentina
J Clin Microbiol 41:1753-5. 2003We developed a seminested PCR for the diagnosis of histoplasmosis that amplifies a portion of the Histoplasma capsulatum H antigen gene... - Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosisF J Gomez
Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0560, USA
J Clin Invest 102:984-95. 1998T cells are essential for controlling infection with Histoplasma capsulatum... - [Spinal cord histoplasmoma. A case report]M Rivierez
Service de Neurochirurgie, Hospital P Zobda Quitman, CHU, 97200 Fort de France
Neurochirurgie 48:44-8. 2002..macrophages containing yeast cells, with PAS and Grocott staining aspects compatible with the presence of Histoplasma capsulatum (Hc)... - Granulomatous interstitial nephritisSamih H Nasr
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Kidney Dis 41:714-9. 2003
Research Grants
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007Protective immunity to the pathogenic fungus, Histoplasma capsulatum (Hc), requires collaboration between T cells and professional antigen presenting cells such as macrophages and dendritic cells...
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2006Protective immunity to the pathogenic fungus, Histoplasma capsulatum (Hc), requires collaboration between T cells and professional antigen presenting cells such as macrophages and dendritic cells...
- CD4+ T CELLS RESPONDING TO SALMONELLA INFECTIONBrad Cookson; Fiscal Year: 2005DESCRIPTION (Adapted from the Applicant's Abstract): Salmonella, Mycobacterium and Histoplasma are facultative intracellular pathogens that live inside phagosomes of host macrophages...
- Functions, Traffic and Targeting of Fungal AdhesinsSCOTT ERDMAN; Fiscal Year: 2003..many fungi pathogenic to humans including Candida species, Cryptococcus neoformans, Aspergillus fumigatus and Histoplasma capsulatum...
- Immunopathogenesis in HistoplasmosisGEORGE DEEPE; Fiscal Year: 2009The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
- Immunopathogenesis in HistoplasmosisGeorge S Deepe; Fiscal Year: 2010The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
- Immunopathogenesis in HistoplasmosisGeorge S Deepe; Fiscal Year: 2010The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
- Gene Circuits that Control Morphology in HistoplasmaAnita Sil; Fiscal Year: 2010..how environmental signals such as temperature regulate morphology and virulence in the fungal pathogen Histoplasma capsulatum. H...
- DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONSMarvin Miller; Fiscal Year: 1993..siderophores for iron assimilation has been clearly demonstrated for some microbes (Aspergillus, Cryptococcus, Histoplasma, other fungi and most bacteria, including mycobacteria) and only implicated in other microbes (Candida albicans,..
- MOLECULAR PATHOGENESIS OF BLASTOMYCOSISBruce Klein; Fiscal Year: 2007..dermatitidis and Histoplasma capsulatum...
- Interaction of H. capsulatum with Dendritic CellsSimon Newman; Fiscal Year: 2006b>Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen of worldwide importance that causes a broad spectrum of disease activity...
- Enzyme Targets-Sterol Synthesis-Opportunistic PathogensWILLIAM NES; Fiscal Year: 2004..and the family of sterol methyl transferase (SMT) enzymes from Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum and Pneumocystis carinii...
- SYNERGY OF HOST DEFENSE MECHANISMS IN LUNGArturo Casadevall; Fiscal Year: 2001..The lung is the portal of entry for many important fungal pathogens including Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis. Mechanisms of host defense against fungal pathogens are poorly understood...