histoplasma

Summary

Summary: A mitosporic Onygenales fungal genus causing HISTOPLASMOSIS in humans and animals. Its single species is Histoplasma capsulatum which has two varieties: H. capsulatum var. capsulatum and H. capsulatum var. duboisii. Its teleomorph is AJELLOMYCES capsulatus.

Top Publications

  1. ncbi RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence
    Chad A Rappleye
    Department of Molecular Microbiology, Campus Box 8230, Washington University, St Louis, MO 63110, USA
    Mol Microbiol 53:153-65. 2004
  2. ncbi Heat shock protein 60: identification of specific epitopes for binding to primary macrophages
    Christiane Habich
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University of Dusseldorf, D 40225 Dusseldorf, Germany
    FEBS Lett 580:115-20. 2006
  3. pmc Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum
    Eric D Holbrook
    Departments of Microbiology and Internal Medicine, The Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio 43210, United States
    J Proteome Res 10:1929-43. 2011
  4. pmc Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor
    Chad A Rappleye
    Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:1366-70. 2007
  5. pmc Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress
    Brian H Youseff
    Departments of Microbiology and Microbial Infection and Immunity, Ohio State University, Columbus, Ohio, United States of America
    PLoS Pathog 8:e1002713. 2012
  6. pmc Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum
    Allan J Guimaraes
    Department of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Infect Immun 77:1357-67. 2009
  7. ncbi The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells
    Mark Scheckelhoff
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 169:5818-26. 2002
  8. pmc Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, São Paulo 14040 903, Brazil
    Infect Immun 72:1637-44. 2004
  9. pmc Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions
    Allan Jefferson Guimarães
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Infect Immun 79:918-27. 2011
  10. pmc Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatum
    Allan Jefferson Guimarães
    Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    PLoS ONE 3:e3449. 2008

Research Grants

  1. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
  2. Histoplasma Gene Expression and Organism Persistence
    ALAN GEORGE SMULIAN; Fiscal Year: 2012
  3. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
  4. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
  5. Point-of-care immunoassay for diagnosis of histoplasmosis in HIV/AIDS
    Sean Bauman; Fiscal Year: 2012
  6. Glucan Particles as a Vaccine Platform for Protective Immunity
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
  7. GM-CSF Regulation of Zinc in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
  8. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2013
  9. MOLECULAR MECHANISMS OF HISTOPLASMA PATHOGENESIS
    William E Goldman; Fiscal Year: 2011
  10. Gene Circuits that Control Morphology in Histoplasma
    Anita Sil; Fiscal Year: 2013

Detail Information

Publications294 found, 100 shown here

  1. ncbi RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence
    Chad A Rappleye
    Department of Molecular Microbiology, Campus Box 8230, Washington University, St Louis, MO 63110, USA
    Mol Microbiol 53:153-65. 2004
    b>Histoplasma capsulatum is a fungal pathogen that causes respiratory and systemic disease by proliferating within macrophages...
  2. ncbi Heat shock protein 60: identification of specific epitopes for binding to primary macrophages
    Christiane Habich
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University of Dusseldorf, D 40225 Dusseldorf, Germany
    FEBS Lett 580:115-20. 2006
    ..Analysis of different pro- and eukaryotic HSP60 species indicated that phylogenetically separate HSP60 species use different binding sites on primary macrophages...
  3. pmc Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum
    Eric D Holbrook
    Departments of Microbiology and Internal Medicine, The Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio 43210, United States
    J Proteome Res 10:1929-43. 2011
    The dimorphic fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease. Within the mammalian host, pathogenic Histoplasma yeast infect, replicate within, and ultimately kill host phagocytes...
  4. pmc Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor
    Chad A Rappleye
    Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:1366-70. 2007
    ..Here, we show that alpha-(1,3)-glucan is present in the outermost layer of the Histoplasma capsulatum yeast cell wall and contributes to pathogenesis by concealing immunostimulatory beta-glucans from ..
  5. pmc Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress
    Brian H Youseff
    Departments of Microbiology and Microbial Infection and Immunity, Ohio State University, Columbus, Ohio, United States of America
    PLoS Pathog 8:e1002713. 2012
    ..The fungal pathogen Histoplasma capsulatum infects both neutrophils and macrophages but the mechanisms enabling Histoplasma yeasts to survive ..
  6. pmc Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum
    Allan J Guimaraes
    Department of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Infect Immun 77:1357-67. 2009
    ..The fungus Histoplasma capsulatum displays an Hsp60 on its cell surface that is a key target of the cellular immune response during ..
  7. ncbi The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells
    Mark Scheckelhoff
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 169:5818-26. 2002
    Immunization with recombinant heat shock protein 60 (rHsp60) from Histoplasma capsulatum or a region of the protein designated fragment 3 (F3) confers protection from a subsequent challenge in mice...
  8. pmc Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, São Paulo 14040 903, Brazil
    Infect Immun 72:1637-44. 2004
    ..We demonstrate that administration of MK 886, a leukotriene synthesis inhibitor, caused Histoplasma capsulatum-infected mice to die by the day 15 of infection, whereas the correlating death rate in untreated ..
  9. pmc Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions
    Allan Jefferson Guimarães
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Infect Immun 79:918-27. 2011
    b>Histoplasma capsulatum can efficiently survive within macrophages, facilitating H. capsulatum translocation from the lung into the lymphatics and bloodstream. We have recently generated monoclonal antibodies (MAbs) to an H...
  10. pmc Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatum
    Allan Jefferson Guimarães
    Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    PLoS ONE 3:e3449. 2008
    Histoplasmosis, due to the intracellular fungus Histoplasma capsulatum, can be diagnosed by demonstrating the presence of antibodies specific to the immunodominant M antigen...
  11. ncbi Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Clin Infect Dis 41:S204-7. 2005
    ..necrosis factor (TNF)-alpha is required for host defenses against a number of pathogenic microbes, including Histoplasma capsulatum...
  12. ncbi Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients
    Maha A Assi
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Medicine (Baltimore) 86:162-9. 2007
    ..Of these, 78 patients had disseminated histoplasmosis and 55 patients had Histoplasma capsulatum fungemia. The mean age of patients was 55 years, 66% were male, and 98% were white...
  13. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ..A protective role for antibodies has not previously been described for host defense against the pathogenic fungus Histoplasma capsulatum (Hc). Mouse mAb's were generated from mice immunized with Hc yeast that binds the cell surface of Hc...
  14. pmc Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum
    Rachael Hanby Webster
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Proc Natl Acad Sci U S A 105:14573-8. 2008
    The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentous form in the soil and, after inhalation of infectious spores, converts to a pathogenic yeast form inside host macrophages in response to temperature...
  15. ncbi Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages
    Kristin H Long
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Immunol 170:487-94. 2003
    b>Histoplasma capsulatum (Hc), is a facultative intracellular fungus that binds to CD11/CD18 receptors on macrophages (Mphi)...
  16. ncbi An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum
    Christopher L Marion
    Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
    Mol Microbiol 62:970-83. 2006
    b>Histoplasma capsulatum is a dimorphic fungus that causes respiratory and systemic disease and is capable of surviving and replicating within macrophages...
  17. pmc Interleukins 17 and 23 influence the host response to Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 200:142-51. 2009
    Host defenses against Histoplasma capsulatum require the action of several cytokines. Here, we explored the influence of interleukin (IL)-17 and IL-23 on immunity to H. capsulatum infection in mice...
  18. ncbi Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 181:8544-51. 2008
    ..were to evaluate whether LTs are involved in the secondary immune response to vaccination in a murine model of Histoplasma capsulatum infection...
  19. pmc Histoplasma capsulatum synthesizes melanin-like pigments in vitro and during mammalian infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 70:5124-31. 2002
    ..This study investigated whether the thermally dimorphic fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin or melanin-like compounds in vitro and during infection...
  20. ncbi Macrophages in host defense against Histoplasma capsulatum
    S L Newman
    Division of Infectious Diseases, University of Cincinnati College of Medicine, OH 45267 0560, USA
    Trends Microbiol 7:67-71. 1999
    ..They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs...
  21. pmc Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
    George S Deepe
    Veterans Affairs Hospital, Cincinnati, OH, USA
    J Leukoc Biol 84:669-78. 2008
    Numerous in vitro studies have demonstrated that Histoplasma capsulatum is engulfed by the diverse populations of phagocytic cells including monocytes/macrophages (Mphi), immature dendritic cells (DC), and neutrophils...
  22. pmc Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling
    Rajagopal N Aravalli
    Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Neuroinflammation 5:30. 2008
    b>Histoplasma capsulatum is a common cause of fungal infection in certain geographic areas, and although most infections are asymptomatic, it is capable of causing histoplasmosis, a disseminated, life-threatening disease, especially in ..
  23. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
    ..fungal pulmonary infections with two agents, Blastomyces dermatitidis an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular pathogen...
  24. pmc Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum
    S L Newman
    Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Infect Immun 68:5668-72. 2000
    Previously we demonstrated that human neutrophils mediate potent and long-lasting fungistasis against Histoplasma capsulatum yeasts and that all of the fungistatic activity resides in the azurophil granules...
  25. ncbi Histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Infect Dis Clin North Am 17:1-19, vii. 2003
    ..This article provides an up-to-date clinical review of histoplasmosis, focusing on recognition, diagnosis, and management...
  26. pmc Neutral storage lipids of Histoplasma capsulatum: effect of culture age
    Robert Zarnowski
    Department of Medical Microbiology and Immunology, University of Wisconsin, 416 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    Curr Microbiol 56:110-4. 2008
    ..age on the distribution of fatty acids among different neutral lipid (NL) classes in the dimorphic fungus Histoplasma capsulatum was investigated...
  27. pmc The yeast-phase virulence requirement for α-glucan synthase differs among Histoplasma capsulatum chemotypes
    Jessica A Edwards
    Department of Microbiology, Center for Microbial Interface Biology, Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Eukaryot Cell 10:87-97. 2011
    b>Histoplasma capsulatum strains can be classified into two chemotypes based on cell wall composition...
  28. pmc SRE1 regulates iron-dependent and -independent pathways in the fungal pathogen Histoplasma capsulatum
    Lena H Hwang
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Eukaryot Cell 11:16-25. 2012
    ..we investigate the role of this transcription factor, Sre1, in the cellular responses of the fungal pathogen Histoplasma capsulatum to iron...
  29. pmc Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization
    Lena H Hwang
    Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 4:e1000044. 2008
    The macrophage is the primary host cell for the fungal pathogen Histoplasma capsulatum during mammalian infections, yet little is known about fungal genes required for intracellular replication in the host...
  30. ncbi Molecular cloning and expression of hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatum
    G Minchiotti
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Biochim Biophys Acta 1131:103-7. 1992
    We have cloned a nucleotide sequence from Histoplasma capsulatum G222B corresponding to a heat inducible hsp82 gene, and determined its entire sequence and the flanking regions...
  31. pmc Histoplasma capsulatum strain variation in both H antigen production and beta-glucosidase activity and overexpression of HAG1 from a telomeric linear plasmid
    K L Fisher
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Infect Immun 67:3312-6. 1999
    The H antigen of the dimorphic fungal pathogen Histoplasma capsulatum was first described over 40 years ago. It is a secreted glycoprotein that is immunogenic during infection...
  32. ncbi Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection
    Carlos Artério Sorgi
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    J Immunol 182:4025-35. 2009
    b>Histoplasma capsulatum (Hc) is a facultative, intracellular parasite of worldwide significance...
  33. ncbi Utilization and cell-surface binding of hemin by Histoplasma capsulatum
    Lisa Anne Agiato Foster
    Biology Department, Trinity College, Hartford, CT 06109, USA
    Can J Microbiol 48:437-42. 2002
    b>Histoplasma capsulatum, a dimorphic fungus capable of causing severe respiratory illness in immunocompromised individuals, resides in macrophages during mammalian infection...
  34. pmc A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis
    Livia Cristina Liporagi Lopes
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Vaccine Immunol 17:1155-8. 2010
    Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis...
  35. pmc The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
    Eszter Lazar-Molnar
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:2658-63. 2008
    ..In this study, we examined the role of PD-1 in a mouse model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus...
  36. pmc Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses
    Michael S Winters
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 202:1136-45. 2010
    The fungal pathogen Histoplasma capsulatum evades the innate and adaptive immune responses and thrives within resting macrophages...
  37. pmc Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii
    James A Fraser
    Department of Molecular Genetics and Microbiology, 322 CARL Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 6:622-9. 2007
    ..we extend this analysis to define the mating type locus of three dimorphic primary human fungal pathogens, Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii, using genomic analysis, direct sequencing, and ..
  38. pmc Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes
    Priscila Costa Albuquerque
    Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, RJ Brazil
    Cell Microbiol 10:1695-710. 2008
    ..In the present study, we examine whether the clinically important ascomycete Histoplasma capsulatum produce vesicles and utilized these structures to secrete macromolecules...
  39. pmc Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Infect Immun 70:3759-67. 2002
    Vaccination with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune response in mice. We explored the cellular and molecular requirements for the efficacy of recombinant Hsp60 in mice...
  40. pmc Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion
    Lucy A Gildea
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, OH 45267, USA
    Infect Immun 73:6803-11. 2005
    b>Histoplasma capsulatum is a fungal pathogen that requires the induction of cell-mediated immunity (CMI) for host survival. We have demonstrated that human dendritic cells (DC) phagocytose H...
  41. pmc Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality
    Jessica A Edwards
    Department of Microbiology, The Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    Infect Immun 79:3348-57. 2011
    ..Using known virulence mutants of Francisella novicida and Histoplasma capsulatum, we confirmed the applicability of these host cells for the quantitative assessment of bacterial and ..
  42. pmc Secreted dipeptidyl peptidase IV activity in the dimorphic fungal pathogen Histoplasma capsulatum
    Kendal G Cooper
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA
    Infect Immun 77:2447-54. 2009
    ..We identified a secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific substrates...
  43. pmc A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages
    Li Shi
    Division of Infectious Diseases, Departments of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Eukaryot Cell 7:1109-17. 2008
    Monoclonal antibodies (MAbs) to a cell surface histone on Histoplasma capsulatum modify murine infection and decrease the growth of H. capsulatum within macrophages. Without the MAbs, H...
  44. pmc Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin
    David van Duin
    Department of Medicine, Division of Infectious Diseases Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 46:3394-400. 2002
    The fungal pathogens Cryptococcus neoformans and Histoplasma capsulatum produce melanin-like pigments in the presence of L-dopa in vitro and during mammalian infection...
  45. ncbi [Diagnosis and treatment of pulmonary histoplasmoma: report of 3 cases]
    Gang Shen
    Department of Thoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Zhonghua Yi Xue Za Zhi 87:760-2. 2007
    ..To investigate the diagnosis and treatment of pulmonary histoplasmoma...
  46. ncbi [A primary investigation on disseminated histoplasmosis in Hubei]
    Xia Li
    The Clinic Laboratory of Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:708-10. 2003
    ..To investigate the epidemiologic features of disseminated histoplasmosis (PDH) in Hubei province...
  47. ncbi Indigenous case of disseminated histoplasmosis from the Penicillium marneffei endemic area of China
    Cunwei Cao
    Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, People s Republic of China
    Mycopathologia 170:47-50. 2010
    ..This case suggests that histoplasmosis should be an important differential diagnosis in immunocompromised patients in southern China and South East Asia (the only endemic area for P. marneffei)...
  48. pmc Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease
    Tai Chung Tseng
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei
    J Clin Microbiol 43:4911-3. 2005
    ..The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass...
  49. ncbi Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient
    Lan Ge
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
    Int J Infect Dis 14:e325-8. 2010
    Histoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which is endemic in many areas of the world but is relatively rare in China...
  50. ncbi Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment
    Jon P Woods
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706 1532, USA
    Fungal Genet Biol 35:81-97. 2002
    b>Histoplasma capsulatum is a thermally dimorphic ascomycete that is a significant cause of respiratory and systemic disease in mammals including humans, especially immunocompromised individuals such as AIDS patients...
  51. ncbi PCR detection of Histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosis
    Julianne Qualtieri
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Ann Clin Lab Sci 39:409-12. 2009
    We report the identification of Histoplasma capsulatum var. capsulatum from whole blood in a renal transplant patient with disseminated histoplasmosis using colorimetric microtiter-plate PCR...
  52. ncbi Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267, USA
    J Immunol 163:4985-93. 1999
    ..These findings reveal a new mechanism whereby GM-CSF contributes to host protection and demonstrate differences in control of primary and secondary histoplasmosis...
  53. pmc Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients
    Christina M Scheel
    Division of Foodborne, Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G 11, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 16:852-8. 2009
    b>Histoplasma capsulatum infection causes significant morbidity and mortality in human immunodeficiency virus-infected individuals, particularly those in countries with limited access to rapid diagnostics or antiretroviral therapies...
  54. pmc Galleria mellonella as a model host to study Paracoccidioides lutzii and Histoplasma capsulatum
    Luciana Thomaz
    Institute of Biomedical Science, Department of Microbiology, University of Sao Paulo, Sao Paulo, Brazil
    Virulence 4:139-46. 2013
    ..work we have explored the use of Galleria mellonella as an infection model for the pathogenic dimorphic fungi Histoplasma capsulatum and Paracoccidioides lutzii...
  55. pmc Cross-reactivity of Paracoccidioides brasiliensis, Histoplasma capsulatum, and Cryptococcus species in the commercial Platelia Aspergillus enzyme immunoassay
    Melissa O Xavier
    Postgraduation Program in Pulmonary Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Vaccine Immunol 16:132-3. 2009
    ..At a cutoff value of 0.5, positivity rates were 50%, 67%, and 50%, respectively. The implications for these findings are discussed...
  56. ncbi Isolated Histoplasma capsulatum meningoencephalitis in an immunocompetent child
    Zachary D Threlkeld
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536 0281, USA
    J Child Neurol 27:532-5. 2012
    ..We describe an immunocompetent 13-year-old girl with atypical symptoms and unusual radiologic findings due to laboratory-confirmed histoplasma meningoencephalitis. She responded well to antifungal therapy.
  57. ncbi Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5
    Francisco J Gomez
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 181:7106-14. 2008
    b>Histoplasma capsulatum (Hc) is a pathogenic fungus that replicates in macrophages (Mphi). In dendritic cells (DC), Hc is killed and fungal Ags are processed and presented to T cells...
  58. pmc Histoplasma mechanisms of pathogenesis--one portfolio doesn't fit all
    Jessica A Edwards
    Department of Microbiology, The Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    FEMS Microbiol Lett 324:1-9. 2011
    b>Histoplasma capsulatum is the leading cause of endemic mycosis in the world. Analyses of clinical isolates from different endemic regions show important diversity within the species...
  59. ncbi Global control of dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Science 312:583-8. 2006
    ..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease...
  60. pmc Detection of histoplasma antigen by a quantitative enzyme immunoassay
    Patricia A Connolly
    MiraVista Diagnostics, 4444 Decatur Blvd, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:1587-91. 2007
    The second-generation Histoplasma antigen immunoassay is semiquantitative, expressing results as a comparison to a negative control, which requires repeat testing of the prior specimen with the current specimen to accurately determine a ..
  61. ncbi Efficacy of cell-free antigens in evaluating cell immunity and inducing protection in a murine model of histoplasmosis
    Anderson Sá-Nunes
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Café s n o, Ribeirao Preto, SP 14040 903, Brazil
    Microbes Infect 7:584-92. 2005
    b>Histoplasma capsulatum is a dimorphic pathogenic fungus that causes a wide spectrum of disease when mycelial fragments are inhaled. Resistance to H. capsulatum is dependent on cellular immunity mediated by T cells and macrophages...
  62. ncbi Histoplasma capsulatum pathogenesis: making a lifestyle switch
    Eric D Holbrook
    Department of Microbiology, Ohio State University, Columbus, OH 43210, United States
    Curr Opin Microbiol 11:318-24. 2008
    The dimorphism of Histoplasma reflects a developmental switch in morphology and lifestyle that is necessary for virulence...
  63. ncbi Reduction in false antigenemia in the second generation Histoplasma antigen assay
    L Joseph Wheat
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Med Mycol 45:169-71. 2007
    We have previously reported false Histoplasma antigenemia in solid organ transplant patients who received rabbit antithymocyte globulin (ATG)...
  64. pmc Evaluation of two nested PCR assays for detection of Histoplasma capsulatum DNA in human tissue
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Keplerstrasse 15, 72074 Tubingen, Germany
    J Clin Microbiol 40:1644-7. 2002
    ..Upon microscopy of tissue, 50 biopsy specimens were histoplasma positive and 50 were negative...
  65. pmc Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples
    Andrea Bracca
    Instituto de Biologia Molecular y Celular de Rosario, IBR CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, 2000 Rosario, Argentina
    J Clin Microbiol 41:1753-5. 2003
    We developed a seminested PCR for the diagnosis of histoplasmosis that amplifies a portion of the Histoplasma capsulatum H antigen gene...
  66. ncbi Histoplasmosis diagnosis using a polymerase chain reaction method. Application on human samples in French Guiana, South America
    Danièle Maubon
    Laboratoire Hospitalo universitaire de Parasitologie et Mycologie Médicale, Equipe EA 3593, UFR de Médecine de l Université des Antilles et de la Guyane, Campus Saint Denis, BP 718, 97336 Cayenne, Guyane Francaise, France
    Diagn Microbiol Infect Dis 58:441-4. 2007
    ..The recently described Hcp100 nested PCR method was used to detect Histoplasma capsulatum DNA in these samples. All of the positive cultures for H...
  67. pmc Production and evaluation of reagents for detection of Histoplasma capsulatum antigenuria by enzyme immunoassay
    Mark D Lindsley
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 14:700-9. 2007
    The detection of urinary Histoplasma capsulatum polysaccharide antigen (HPA) by enzyme immunoassay (EIA) has proven useful for the presumptive diagnosis of histoplasmosis in AIDS patients...
  68. ncbi Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis, IN, USA
    Diagn Microbiol Infect Dis 43:29-37. 2002
    ..This report is based soley upon the experience at the Histoplasmosis Reference Laboratory, and can not be used in interpretation of results of Histoplasma antigen testing done at other laboratories.
  69. ncbi Leukotriene B4-loaded microspheres as a new approach to enhance antimicrobial responses in Histoplasma capsulatum-infected mice
    Roberto Nicolete
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    Int J Antimicrob Agents 34:365-9. 2009
    ..is a pulmonary disease characterised by chronic granulomatous and suppurative inflammatory reactions caused by Histoplasma capsulatum...
  70. ncbi The respiratory burst response to Histoplasma capsulatum by human neutrophils. Evidence for intracellular trapping of superoxide anion
    R A Schnur
    Department of Internal Medicine, University of Cincinnati College of Medicine, OH 45267
    J Immunol 144:4765-72. 1990
    Human neutrophils (PMN) have received little attention as to the role they play in host defense against Histoplasma capsulatum (Hc)...
  71. ncbi Regulation of infection with Histoplasma capsulatum by TNFR1 and -2
    R Allendoerfer
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 165:2657-64. 2000
    ..concerted action of several cytokines is necessary for resolution of both primary and secondary infection with Histoplasma capsulatum...
  72. ncbi False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen
    Ashok Srinivasan
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Infect Dis J 28:447-9. 2009
    We report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic...
  73. pmc Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis
    Shih Hung Hsieh
    Graduate Institute of Immunology, National Taiwan University College of Medicine, No 1, Ren Ai Road, Section 1, Taipei, Taiwan
    Infect Immun 79:4493-502. 2011
    We have previously revealed the protective role of CD8(+) T cells in host defense against Histoplasma capsulatum in animals with CD4(+) T cell deficiency and demonstrated that sensitized CD8(+) T cells are restimulated in vitro by ..
  74. ncbi Cell-mediated immunity to Histoplasma capsulatum
    S L Newman
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560, USA
    Semin Respir Infect 16:102-8. 2001
    b>Histoplasma capsulatum is a facultative intracellular pathogen, and the causative agent of the most common systemic fungal infection...
  75. pmc Detection of the 70-kilodalton histoplasma capsulatum antigen in serum of histoplasmosis patients: correlation between antigenemia and therapy during follow-up
    B L Gomez
    Corporacion para Investigaciones Biologicas, A A 73 78, Medellin, Colombia
    J Clin Microbiol 37:675-80. 1999
    ..of antibody responses for both diagnosis and follow-up may be of limited use, whereas the detection of Histoplasma capsulatum var. capsulatum antigens may provide a more practical approach...
  76. pmc Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages
    Diane O Inglis
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Infect Immun 78:3871-82. 2010
    b>Histoplasma capsulatum is the most common cause of fungal respiratory infections and can lead to progressive disseminated infections, particularly in immunocompromised patients...
  77. ncbi [Fatal miliary tuberculosis in an HIV-infected Cameroon woman: disseminated histoplasmosis due to Histoplasma capsulatum capsulatum]
    C E Mandengue
    Service de Medecine Interne, Hopital General, Yaounde, Cameroun
    Med Trop (Mars) 71:615-7. 2011
    The purpose of this report is to describe the first Cameroonian case of disseminated histoplasmosis due to Histoplasma capsulatum capsulatum in association with HIV infection. The patient was a 34-year-old HIV1 infected woman...
  78. pmc Structural features responsible for the biological stability of Histoplasma's virulence factor CBP
    Moriah R Beck
    Department of Molecular Microbiology, Washington University, St Louis, Missouri 63110, USA
    Biochemistry 47:4427-38. 2008
    The virulence factor CBP is the most abundant protein secreted by Histoplasma capsulatum, a pathogenic fungus that causes histoplasmosis...
  79. pmc Experimental annotation of the human pathogen Histoplasma capsulatum transcribed regions using high-resolution tiling arrays
    Mark Voorhies
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    BMC Microbiol 11:216. 2011
    The fungal pathogen Histoplasma capsulatum is thought to be the most common cause of fungal respiratory infections in immunocompetent humans, yet little is known about its biology...
  80. ncbi Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast
    Jr Shiuan Lin
    Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Leukoc Biol 88:95-106. 2010
    The yeast cells of dimorphic fungal pathogen Histoplasma reside primarily within the macrophages of an infected host; the interaction between the yeast and macrophage has a profound impact on host defense against the fungus...
  81. pmc Histoplasma capsulatum heat-shock 60 orchestrates the adaptation of the fungus to temperature stress
    Allan Jefferson Guimarães
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, United States of America
    PLoS ONE 6:e14660. 2011
    ..A 62 kDa Hsp (Hsp60) of Histoplasma capsulatum (Hc) is an immunodominant antigen and the major surface ligand to CR3 receptors on macrophages...
  82. doi Colonic coinfection of histoplasma and cytomegalovirus mimicking carcinoma in a patient with HIV/AIDS
    Xinqing Fan
    Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA
    Gastrointest Endosc 67:977-8; discussion 978. 2008
  83. pmc Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum
    Meggan C Laskowski
    Infectious Disease Division, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0560, USA
    BMC Microbiol 10:49. 2010
    b>Histoplasma capsulatum is a pathogenic ascomycete fungus that rapidly loses mating ability in culture...
  84. pmc Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection
    Wendy A Szymczak
    Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Infect Immun 78:2125-37. 2010
    Excessive production of interleukin-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2...
  85. ncbi Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:5353-62. 2003
    We determined whether the absence of IL-10 in mice influenced protective and memory immunity to Histoplasma capsulatum. IL-10(-/-) mice cleared primary and secondary infection more rapidly than wild-type controls...
  86. ncbi Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan
    A I Medeiros
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Inflamm Res 53:351-4. 2004
    ..and eotaxin and in vivo migration in the peritoneal cavity model, in mice inoculated with live yeast forms of Histoplasma capsulatum or the beta-glucan cell wall component of this fungus, and the influence of a leukotriene ..
  87. ncbi Histoplasma capsulatum yeast cells attach and agglutinate human erythrocytes
    M L Taylor
    Department of Microbiología Parasitología, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Med Mycol 42:287-92. 2004
    The ability of yeast cells of Histoplasma capsulatum to attach and agglutinate human erythrocytes has been described. This is the first report involving these yeasts in the hemagglutination phenomenon...
  88. pmc Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients
    Pierre Loulergue
    University Paris V, Paris, France
    Emerg Infect Dis 13:1647-52. 2007
    African histoplasmosis caused by Histoplasma capsulatum var. duboisii is an invasive fungal infection endemic in central and west Africa. Most of its ecology and pathogenesis remain unknown. H. capsulatum var...
  89. ncbi Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopes
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    J Nucl Med 45:313-20. 2004
    ..We compared the susceptibility of human pathogenic fungi Cryptococcus neoformans (CN) and Histoplasma capsulatum (HC) to external gamma-radiation and to the organism-specific mAbs 18B7 and 9C7, respectively, ..
  90. ncbi Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages
    Jeremy Hilty
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Med Mycol 49:633-42. 2011
    b>Histoplasma capsulatum is a dimorphic fungal pathogen that survives and replicates within macrophages (MΦ). Studies in human and murine MΦ demonstrate that the intracellular growth of H...
  91. ncbi Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils
    Simon L Newman
    Division of Infectious Diseases, University of Cincinnati College of Medicine, OH, USA
    Methods Mol Med 118:181-91. 2005
    b>Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen indigenous to the Ohio and Mississippi River Valleys in the United States...
  92. pmc Interaction of murine macrophage-membrane proteins with components of the pathogenic fungus Histoplasma capsulatum
    M L Taylor
    Department of Microbiología Parasitología, Faculty of Medicine, UNAM, Mexico, DF, Mexico
    Clin Exp Immunol 113:423-8. 1998
    The interaction of macrophage-membrane proteins and histoplasmin, a crude antigen of the pathogenic fungus Histoplasma capsulatum, was studied using murine peritoneal macrophages...
  93. pmc Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDS
    Maria Eugenia Gutierrez
    Department of Infectious Diseases, Arnulfo Arias Madrid Hospital, Panama City, Panama
    Clin Vaccine Immunol 15:681-3. 2008
    ..Whether infection with these Latin American genotypes produces positive results in the Histoplasma antigen assay has not been reported...
  94. ncbi Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts
    Simon L Newman
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267 0560, USA
    Med Mycol 49:356-64. 2011
    Infections due to Histoplasma capsulatum occur as a result of the inhalation of airborne microconidia of the mold into the alveoli of the lungs...
  95. ncbi Interaction of Histoplasma capsulatum yeasts with galactosylated surface molecules of murine macrophages
    Esperanza Duarte-Escalante
    Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Arch Med Res 34:176-83. 2003
    b>Histoplasma capsulatum (H.c.) yeast-cell binding to glycosylated surface molecules of murine macrophages was studied using attachment inhibition assays with different carbohydrate-treated H.c...
  96. pmc Potential role for extracellular glutathione-dependent ferric reductase in utilization of environmental and host ferric compounds by Histoplasma capsulatum
    M M Timmerman
    Department of Medical Microbiology and Immunology, Microbiology Doctoral Training Program, University of Wisconsin, Madison 53706, USA
    Infect Immun 69:7671-8. 2001
    The mammalian host specifically limits iron during Histoplasma capsulatum infection, and fungal acquisition of iron is essential for productive infection. H...
  97. ncbi Cloning and analysis of mold-specific genes in the dimorphic fungus Histoplasma capsulatum
    X Tian
    Biological Sciences Department, Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS 39406-5018, USA
    Gene 275:107-14. 2001
    A critical feature in the pathogenesis of the respiratory pathogen Histoplasma capsulatum is the conversion from the mold form (found in soil) to the yeast form in the lungs of the host...
  98. pmc Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis
    G S Deepe
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267-0560, USA
    Infect Immun 69:3128-34. 2001
    We previously reported that immunization with H antigen from Histoplasma capsulatum did not protect mice against an intravenous challenge with yeasts...
  99. pmc Expression and interstrain variability of the YPS3 gene of Histoplasma capsulatum
    Megan L Bohse
    Department of Medical Microbiology and Immunology, 420 SMI, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Eukaryot Cell 6:609-15. 2007
    The YPS3 locus of the dimorphic fungus Histoplasma capsulatum encodes a secreted and surface-localized protein specific to the pathogenic yeast phase. In this study we examined this locus in 32 H. capsulatum strains and variants...
  100. pmc A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum
    Mark Scheckelhoff
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Infect Immun 73:2129-34. 2005
    Immunization of mice with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein designated F3 confers protection. Vbeta8.1/8.2+ T cells are critically important for the protective efficacy of this antigen...
  101. ncbi The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse
    J A Mayfield
    Department of Molecular and Cell Biology, The University of California Berkeley, Berkeley, CA 94720 3202, USA
    Genes Immun 8:468-74. 2007
    The pathogenic fungus Histoplasma capsulatum causes disease ranging from mild to fatal in healthy and immunocompromised humans. Infection rates reach 80% in endemic areas, including the Midwestern United States...

Research Grants62

  1. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..dermatitidis as well as related dimorphic fungi Coccidioides posadasii and Histoplasma capsulatum...
  2. Histoplasma Gene Expression and Organism Persistence
    ALAN GEORGE SMULIAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The ability of Histoplasma capsulatum (Hc), to persist within mammalian tissue after initial infection is fundamental to the pathogenesis of disease...
  3. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
  4. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..We hypothesize that Ag-specific CD4+ T cells that protect against dimorphic fungi - Blastomyces, Histoplasma, and Coccidioides - enter the memory pool and retain the ability long-term to produce IL-17 on re-exposure to ..
  5. Point-of-care immunoassay for diagnosis of histoplasmosis in HIV/AIDS
    Sean Bauman; Fiscal Year: 2012
    ..rates in HIV/AIDS can be >20%, with mortality rates >30% in resource-limited countries where the fungus, Histoplasma capsulatum, is endemic. Early diagnosis and treatment are essential to reducing this high mortality rate...
  6. Glucan Particles as a Vaccine Platform for Protective Immunity
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..Moreover, mice vaccinated with GPs containing antigen from Histoplasma capsulatum (Hc) survive otherwise lethal experimental histoplasmosis...
  7. GM-CSF Regulation of Zinc in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The dimorphic fungus, Histoplasma capsulatum (Hc), is endemic to the midwestern and southeastern United States and is the most frequent cause of fungal respiratory infections...
  8. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
  9. MOLECULAR MECHANISMS OF HISTOPLASMA PATHOGENESIS
    William E Goldman; Fiscal Year: 2011
    b>Histoplasma capsulatum is one of the classic [unreadable]dimorphic[unreadable] fungal pathogens, undergoing a temperature-induced transition from a mold form that grows in soil to a yeast form that establishes infection in lung ..
  10. Gene Circuits that Control Morphology in Histoplasma
    Anita Sil; Fiscal Year: 2013
    ..how environmental signals such as temperature regulate morphology and virulence in the fungal pathogen Histoplasma capsulatum. H...
  11. Molecular and Cellular Determinants of Immunity to Histoplasmosis
    George S Deepe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary The dimorphic fungus, Histoplasma capsulatum (Hc) is found world-wide, and endemic to the Midwestern and southeastern United States...
  12. Virulence factor discovery in the secreted proteome of Histoplasma capsulatum
    Chad A Rappleye; Fiscal Year: 2012
    ..Yeast cells of the dimorphic fungal pathogen, Histoplasma capsulatum, invade, replicate within, and ultimately kill host macrophages...
  13. Myeloid Cell KLF2 and IL-4 in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The dimorphic fungus, Histoplasma capsulatum (Hc), is endemic to the midwestern and southeastern US and is the most frequent cause of fungal respiratory infection...
  14. Natural products from a human-asssociated fungal pathogen
    Anita Sil; Fiscal Year: 2013
    ..We propose a systematic approach to identify natural products from the fungal pathogen Histoplasma capsulatum, which is a soil organism that spends much of its time in the mammalian lung...
  15. Role and Regulation of a Molecular Mimic in Histoplasma Pathogenesis
    William E Goldman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Histoplasma capsulatum is one of the classic "dimorphic" fungal pathogens, undergoing a temperature-induced transition from a mold form that grows in soil to a yeast form that establishes infection ..
  16. MOLECULAR PATHOGENESIS OF BLASTOMYCOSIS
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..dermatitidis and Histoplasma capsulatum...
  17. Chemokine-Cytokine Nexus in Fungal Immunity
    GEORGE DEEPE; Fiscal Year: 2009
    Project Summary The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic...
  18. Molecular dissection of Histoplasma-induced host-cell death
    Anita Sil; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The long-term goal of our research is to understand how the fungal pathogen Histoplasma capsulatum causes disease. H...
  19. GM-CSF-Induced Metal Sequestration and Histoplasma
    George S Deepe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The dimorphic fungus, Histoplasma capsulatum (Hc), is endemic to the Midwestern and southeastern United States and is the most frequent cause of fungal respiratory infections...
  20. PARACOCCIDIOIDOMYCOSIS--EVOLUTION AND STRAIN-TYPING
    John Taylor; Fiscal Year: 2002
    ..1) Fungal species concepts are morphological, but our experience with Histoplasma capsulatum, Coccidioides immitis and Aspergillus flavus shows that a morphological species can harbor more than ..
  21. CD4+ T CELLS RESPONDING TO SALMONELLA INFECTION
    Brad Cookson; Fiscal Year: 2005
    DESCRIPTION (Adapted from the Applicant's Abstract): Salmonella, Mycobacterium and Histoplasma are facultative intracellular pathogens that live inside phagosomes of host macrophages...
  22. Functions, Traffic and Targeting of Fungal Adhesins
    SCOTT ERDMAN; Fiscal Year: 2003
    ..many fungi pathogenic to humans including Candida species, Cryptococcus neoformans, Aspergillus fumigatus and Histoplasma capsulatum...
  23. INTERACTION OF H CAPSULATUM WITH ALVEOLAR MACROPHAGE
    Simon Newman; Fiscal Year: 1999
    ..b>Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen of worldwide importance that causes a broad spectrum of disease ..
  24. IFN-GAMMA IN EXPERIMENTAL MURINE HISTOPLASMOSIS
    BETTY WU HSIEH; Fiscal Year: 1991
    b>Histoplasma capsulatum is a facultative intracellular parasite of mononuclear phagocytic cells...
  25. RAS GENE FUNCTION IN FUNGAL DIMORPHISM
    JUDITH MEDOFF; Fiscal Year: 1990
    ..understand the molecular mechanism by which cAMP modulates differentiation of the dimorphic, pathogenic fungus, Histoplasma capsulatum. H...
  26. FLOW CYTOMETER WITH CELL SORTING CAPABILITY
    RAM TEWARI; Fiscal Year: 1992
    ..Tewari will use the instrument for two projects: 1) Natural and immune cytotoxicity to Histoplasma and 2) Interaction of human endothelial cells with Histoplasma. Cooper will...
  27. INTERACTION OF H CAPSULATUM WITH MACROPHAGES AND PMN
    Simon Newman; Fiscal Year: 2000
    DESCRIPTION (adapted from the applicant's abstract): Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen of worldwide importance that causes a broad spectrum of disease activity...
  28. Comparative Genomics of Histoplasma and Blastomyces
    William Goldman; Fiscal Year: 2006
    ..b>Histoplasma capsulatum and Blastomyces dermatitidis are phylogenetically the most closely related among the dimorphic fungi ..
  29. ISOLATION & CHARACTERIZATION OF CYSTEINE OXIDASE GENE
    Glenmore Shearer; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicant's abstract): Histoplasma capsulatum is an important human pathogen, infecting an estimated 500,000 individuals per year in the United States alone...
  30. Genomic Resources for Histoplasma capsulatum
    Elaine Mardis; Fiscal Year: 2002
    The goal of this proposal is to produce comprehensive genomic resources for the fungal pathogen Histoplasma capsulatum. This resource will enhance and expedite the ability of H...
  31. Enzyme Targets-Sterol Synthesis-Opportunistic Pathogens
    WILLIAM NES; Fiscal Year: 2004
    ..and the family of sterol methyl transferase (SMT) enzymes from Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum and Pneumocystis carinii...
  32. H. CAPSULATUM-REACTIVE MURINE T CELL CLONES AND HYBRIDS
    GEORGE DEEPE; Fiscal Year: 1991
    ..long-term objectives of this research proposal are to study the biology of T lymphocytes that are reactive with Histoplasma capsulatum...
  33. MOLECULAR BASES OF INTERFERON-INDUCED FUNGISTATIS
    DEXTER HOWARD; Fiscal Year: 1993
    The overall goal of the work is to discover how the intracellular growth of the zoopathogenic fungus Histoplasma capsulatum is terminated within macrophages of a recovering host...
  34. IMMUNOREGULATION IN DISSEMINATED HISTOPLASMOSIS
    WARD BULLOCK; Fiscal Year: 1990
    ..are to study the perturbations of immunoregulation that are associated with infection by the pathogenic yeast, Histoplasma capsulatum (Hc)...
  35. INTERACTIONS OF HUMAN ENDOTHELIAL CELLS WITH HISTOPLASMA
    RAM TEWARI; Fiscal Year: 1990
    ..The infection is acquired by inhalation of Histoplasma capsulatum (HC) and the organism disseminates to extrapulmonary sites by both lymphatic and blood streams...
  36. Dimorphism related genes in Histoplasma capsulatum
    Glenmore Shearer; Fiscal Year: 2001
    DESCRIPTION (Verbatim from Applicant's Abstract): Yeast/mold dimorphism in Histoplasma capsulatum (Hc) is critical to the pathogenesis of the lung disease histoplasmosis which infects an estimated 500,000 Americans each year...
  37. STUDIES OF RIBOSOMES FROM HISTOPLASMA CAPSULATUM
    H Swim; Fiscal Year: 1980
    ..of this project is to characterize the physical and certain biological properties of ribosomes of the fungus Histoplasma capsulatum. The biochemical makeup of ribosomes from the yeast and mycelial phases of growth of H...
  38. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    Infection with the systemic fungi, Histoplasma capsulatum and Blastomyces dermatitidis afflict a large proportion of the population of the United States. H. capsulatum is the leading cause of fungal respiratory disease within the U.S...
  39. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    Protective immunity to the pathogenic fungus, Histoplasma capsulatum (Hc), requires collaboration between T cells and professional antigen presenting cells such as macrophages and dendritic cells...
  40. H. CAPSULATUM INTERACTIONS WITH MURINE MACROPHAGES
    J Little; Fiscal Year: 1991
    The dimorphic fungus Histoplasma capsulatum (Hc) is one of a small group of organisms whose virulence seems to relate to its ability to survive within the macrophage rather than its avoidance of ingestion...
  41. BD LSR II Blue Laser Flow cytometer
    Matyas Sandor; Fiscal Year: 2006
    ..Analysis of unfixed samples from animals infected with diverse pathogens including Histoplasma and Trypanosoma would be a real advance to our research programs...
  42. HOW PHAGOCYTES DEAL WITH FUNGI
    DEXTER HOWARD; Fiscal Year: 1980
    ..The purpose is to be achieved by the following comparative studies: 1. Studies with Histoplasma capsulatum: a...
  43. IMMUNITY OF NONLYMPHOID CELLS TO INTRACELLULAR INFECTION
    JACOB FRENKEL; Fiscal Year: 1980
    ..Mice and hamsters, infected with Toxoplasma, Besnoitia, Histoplasma, murine cytomegalovirus and Listeria monocytogenes, are to be studied...
  44. Secondary infections during mycobacterial disease
    Matyas Sandor; Fiscal Year: 2004
    ..bacille Calmette Gurin (BCG), to examine the effect of super-infection with influenza virus and the fungus Histoplasma capsulatum...
  45. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    b>Histoplasma capsulatum is an important endemic, intracellular fungal pathogen that can cause life threatening disseminated disease, particularly in individuals with impaired immunity...
  46. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  47. Interaction of H. capsulatum with Dendritic Cells
    Simon Newman; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen of worldwide importance that causes a broad spectrum of disease activity...
  48. MOLECULAR MECHANISMS OF HISTOPLASMA PATHOGENESIS
    William Goldman; Fiscal Year: 2008
    b>Histoplasma capsulatum is a classic dimorphic fungal pathogen that initially infects mammalian hosts as a mold and then undergoes a complete transition to a yeast...
  49. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2003
    ..abstract_text> ..
  50. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
    ..abstract_text> ..
  51. The 2007 LAM Foundation Lymphangioleiomyomatosis International Research Conferenc
    Francis McCormack; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..Patient safety will be monitored by an NIH Data Safety Monitoring Board (DSMB). The MILES trial is designed as a pivotal study to determine if sirolimus is effective in stabilizing or improving lung function in patients with LAM. ..