cryptococcus neoformans

Summary

Summary: A species of the fungus Cryptococcus, which causes CRYPTOCOCCOSIS. Its teleomorph is Filobasidiella neoformans.

Top Publications

  1. pmc Fungal cell gigantism during mammalian infection
    Oscar Zaragoza
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS Pathog 6:e1000945. 2010
  2. pmc Cryptococcal cell morphology affects host cell interactions and pathogenicity
    Laura H Okagaki
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Pathog 6:e1000953. 2010
  3. pmc Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Gray Jackson 504, 55 Fruit St, Boston, Massachusetts 02114, USA
    Infect Immun 73:3842-50. 2005
  4. pmc Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    Oliver W Liu
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th St, GH N372C, San Francisco, CA 94158, USA
    Cell 135:174-88. 2008
  5. ncbi Deciphering the model pathogenic fungus Cryptococcus neoformans
    Alexander Idnurm
    Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Microbiol 3:753-64. 2005
  6. pmc Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation
    Ambrose Jong
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cell Microbiol 10:1854-65. 2008
  7. pmc Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung
    John J Osterholzer
    Veterans Affairs Ann Arbor Health System, Ann Arbor, 2215 Fuller Rd, Ann Arbor, MI 48105, USA
    Am J Pathol 174:932-43. 2009
  8. pmc Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3)
    Sheng He Huang
    Department of Pediatrics, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Biol Chem 286:34761-9. 2011
  9. pmc Urease as a virulence factor in experimental cryptococcosis
    G M Cox
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 68:443-8. 2000
  10. pmc Characterization of the PMT gene family in Cryptococcus neoformans
    Sven D Willger
    Institut fur Mikrobiologie, Molekulare Mykologie, Heinrich Heine Universitat, Dusseldorf, Germany
    PLoS ONE 4:e6321. 2009

Detail Information

Publications328 found, 100 shown here

  1. pmc Fungal cell gigantism during mammalian infection
    Oscar Zaragoza
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS Pathog 6:e1000945. 2010
    ..The encapsulated pathogenic fungus Cryptococcus neoformans is not considered a dimorphic fungus, and is predominantly found in host tissues as round yeast cells...
  2. pmc Cryptococcal cell morphology affects host cell interactions and pathogenicity
    Laura H Okagaki
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Pathog 6:e1000953. 2010
    b>Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm...
  3. pmc Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Gray Jackson 504, 55 Fruit St, Boston, Massachusetts 02114, USA
    Infect Immun 73:3842-50. 2005
    Evaluation of Cryptococcus neoformans virulence in a number of nonmammalian hosts suggests that C. neoformans is a nonspecific pathogen. We used the killing of Galleria mellonella (the greater wax moth) caterpillar by C...
  4. pmc Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    Oliver W Liu
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th St, GH N372C, San Francisco, CA 94158, USA
    Cell 135:174-88. 2008
    The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals...
  5. ncbi Deciphering the model pathogenic fungus Cryptococcus neoformans
    Alexander Idnurm
    Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Microbiol 3:753-64. 2005
    b>Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen ..
  6. pmc Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation
    Ambrose Jong
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cell Microbiol 10:1854-65. 2008
    Pathogenic fungus Cryptococcus neoformans has a predilection for the central nervous system causing devastating meningoencephalitis. Traversal of C...
  7. pmc Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung
    John J Osterholzer
    Veterans Affairs Ann Arbor Health System, Ann Arbor, 2215 Fuller Rd, Ann Arbor, MI 48105, USA
    Am J Pathol 174:932-43. 2009
    Urease, a major virulence factor for Cryptococcus neoformans, promotes lethal meningitis/encephalitis in mice. The effect of urease within the lung, the primary site of most invasive fungal infections, is unknown...
  8. pmc Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3)
    Sheng He Huang
    Department of Pediatrics, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Biol Chem 286:34761-9. 2011
    b>Cryptococcus neoformans is a neurotropic fungal pathogen, which provokes the onset of devastating meningoencephalitis. We used human brain microvascular endothelial cells (HBMEC) as the in vitro model to investigate how C...
  9. pmc Urease as a virulence factor in experimental cryptococcosis
    G M Cox
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 68:443-8. 2000
    ..b>Cryptococcus neoformans is a significant human pathogenic fungus that produces large amounts of urease; thus we wanted to ..
  10. pmc Characterization of the PMT gene family in Cryptococcus neoformans
    Sven D Willger
    Institut fur Mikrobiologie, Molekulare Mykologie, Heinrich Heine Universitat, Dusseldorf, Germany
    PLoS ONE 4:e6321. 2009
    ..Protein-O-mannosyltransferases (Pmt's) catalyze the initial step of protein-O-glycosylation, the addition of mannose residues to serine or threonine residues of target proteins...
  11. pmc Cryptococcus neoformans capsular polysaccharide and exopolysaccharide fractions manifest physical, chemical, and antigenic differences
    Susana Frases
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eukaryot Cell 7:319-27. 2008
    The human pathogenic fungus Cryptococcus neoformans has a large polysaccharide (PS) capsule and releases copious amounts of PS into cultures and infected tissues...
  12. pmc Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii
    Wieland Meyer
    Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, University of Sydney Western Clinical School at Westmead Hospital, Westmead, Australia
    Med Mycol 47:561-70. 2009
    ..the consensus multi-locus typing scheme established by the Cryptococcal Working Group I (Genotyping of Cryptococcus neoformans and C...
  13. pmc HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
    The fungal pathogen Cryptococcus neoformans is a major cause of illness in immunocompromised individuals such as AIDS patients...
  14. pmc Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion
    Michal A Olszewski
    Veteran s Administration Medical Center Ann Arbor, Ann Arbor, Michigan, USA
    Am J Pathol 164:1761-71. 2004
    ..neoformans...
  15. pmc Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier
    Yun C Chang
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 72:4985-95. 2004
    Cryptococcal meningoencephalitis develops as a result of hematogenous dissemination of inhaled Cryptococcus neoformans from the lung to the brain. The mechanism(s) by which C...
  16. pmc Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain
    Meiqing Shi
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 120:1683-93. 2010
    ..Here, using intravital microscopy, we have shown that Cryptococcus neoformans, a yeast pathogen that causes meningoencephalitis, stops suddenly in mouse brain capillaries of a similar ..
  17. pmc Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis
    Eleftherios Mylonakis
    Division of Infectious Diseases and Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Proc Natl Acad Sci U S A 99:15675-80. 2002
    ..laurentii) or longer than (C. kuetzingii) those fed on E. coli. However, the human pathogenic yeast Cryptococcus neoformans killed C. elegans, and the C. neoformans polysaccharide capsule as well as several C...
  18. ncbi Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults
    Neil French
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    AIDS 16:1031-8. 2002
    Despite the recognition of Cryptococcus neoformans as a major cause of meningitis in HIV-infected adults in sub-Saharan Africa, little is known about the relative importance of this potentially preventable infection as a cause of ..
  19. pmc Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes
    Edward Sionov
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1000848. 2010
    b>Cryptococcus neoformans is a haploid environmental organism and the major cause of fungal meningoencephalitis in AIDS patients. Fluconazole (FLC), a triazole, is widely used for the maintenance therapy of cryptococcosis...
  20. ncbi Methods for using Galleria mellonella as a model host to study fungal pathogenesis
    Beth Burgwyn Fuchs
    Division of Infectious, Massachusetts General Hospital, Boston, MA, USA
    Virulence 1:475-82. 2010
    ..virulence, filamentation and fungal cell associates with insect hemocytes using Candida albicans and Cryptococcus neoformans to illustrate the use of this model...
  21. ncbi Expulsion of live pathogenic yeast by macrophages
    Hansong Ma
    Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Curr Biol 16:2156-60. 2006
    ..However, we now demonstrate that the human fungal pathogen Cryptococcus neoformans is able to escape from within macrophages without killing the host cell by a novel expulsive mechanism...
  22. pmc Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host
    Michael S Price
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    MBio 2:e00103-11. 2011
    b>Cryptococcus neoformans is an important fungal pathogen of immunocompromised individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the immunocompetent. During initial infection, C...
  23. ncbi A PCR-based strategy to generate integrative targeting alleles with large regions of homology
    Robert C Davidson
    Department of Molecular Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Microbiology 148:2607-15. 2002
    b>Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle for which genetic and molecular techniques are well developed. The entire genome sequence of one C. neoformans strain is nearing completion...
  24. pmc Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
    Eukaryot Cell 8:1803-7. 2009
    b>Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system...
  25. ncbi Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy
    P G Pappas
    University of Alabama at Birmingham Medical Center, Birmingham, AL 35294 0006, USA
    Clin Infect Dis 33:690-9. 2001
    ..Overall mortality was 30%, and mortality attributable to cryptococcosis was 12%. Cryptococcosis continues to be an important infection in HIV-negative patients and is associated with substantial overall and cause-specific mortality...
  26. pmc Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport
    Marcio L Rodrigues
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, Brazil
    Eukaryot Cell 6:48-59. 2007
    ..A central question in the biology of Cryptococcus neoformans, the causative agent of cryptococcosis, is the mechanism by which capsular polysaccharide synthesized ..
  27. pmc Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans
    J A Alspaugh
    Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 21:3179-91. 2001
    b>Cryptococcus neoformans is an opportunistic fungal pathogen that infects the human central nervous system...
  28. pmc Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China
    Jianghan Chen
    Shanghai Changzheng Hospital, Shanghai, People s Republic of China
    Emerg Infect Dis 14:755-62. 2008
    ..determine the population structure of the cryptococcosis agents in China, we analyzed the genotype of 120 Cryptococcus neoformans and 9 Cryptococcus gattii strains isolated from 1980 through 2006 from cryptococcosis patients residing ..
  29. doi Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells
    Ambrose Jong
    Division of Hematology Oncology, The Saban Research Institute, Childrens Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Cell Microbiol 10:1313-26. 2008
    Pathogenic yeast Cryptococcus neoformans causes devastating cryptococcal meningoencephalitis. Our previous studies demonstrated that C...
  30. pmc Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis
    Anthony Lee
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Infect Immun 78:4213-25. 2010
    b>Cryptococcus neoformans is a fungal pathogen that encounters various microenvironments during growth in the mammalian host, including intracellular vacuoles, blood, and cerebrospinal fluid (CSF)...
  31. pmc Spores as infectious propagules of Cryptococcus neoformans
    Rajesh Velagapudi
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Infect Immun 77:4345-55. 2009
    b>Cryptococcus neoformans and Cryptococcus gattii are closely related pathogenic fungi that cause pneumonia and meningitis in both immunocompromised and immunocompetent hosts and are a significant global infectious disease risk...
  32. pmc Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages
    Gary M Cox
    Department of Medicine and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA
    Infect Immun 71:173-80. 2003
    ..of fungal infections, we cloned the Cu,Zn SOD-encoding gene (SOD1) from the human-pathogenic yeast Cryptococcus neoformans and made mutants via targeted disruption...
  33. pmc Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence
    Amy J Reese
    Department of Biological Sciences, Cedar Crest College, Allentown, PA 18104 6196, USA
    Mol Microbiol 63:1385-98. 2007
    ..The pathogenic fungus Cryptococcus neoformans additionally anchors its polysaccharide capsule to the cell surface via alpha(1-3) glucan in the wall...
  34. pmc A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans
    Cheryl D Chun
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e22. 2007
    ..mutants defective in growth under hypoxic conditions, but normal for growth in normoxic conditions, in Cryptococcus neoformans, the most common cause of fungal meningitis...
  35. pmc Molecular typing of IberoAmerican Cryptococcus neoformans isolates
    Wieland Meyer
    University of Sydney, Sydney, Australia
    Emerg Infect Dis 9:189-95. 2003
    A network was established to acquire basic knowledge of Cryptococcus neoformans in IberoAmerican countries...
  36. ncbi Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages
    Mauricio Alvarez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Curr Biol 16:2161-5. 2006
    b>Cryptococcus neoformans (Cn) is an encapsulated yeast that is a facultative intracellular pathogen and a frequent cause of human disease...
  37. pmc Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99
    Yanmei Zhang
    VA Ann Arbor Health System, Ann Arbor, Michigan 48105, USA
    Am J Pathol 175:2489-500. 2009
    The present study dissected the role of a Th2 bias in pathogenesis of Cryptococcus neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and IL-4/IL-13 double knockout mice...
  38. pmc Cryptococcus neoformans mates on pigeon guano: implications for the realized ecological niche and globalization
    Kirsten Nielsen
    Department of Molecular Genetics and Microbiology, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 6:949-59. 2007
    ..The growth and development of Cryptococcus neoformans and Cryptococcus gattii on pigeon guano were examined to determine whether these two species occupy the ..
  39. pmc Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin
    Sitali P Simwami
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Pathog 7:e1001343. 2011
    ..b>Cryptococcus neoformans variety grubii (Cng, serotype A) constitutes the most ubiquitous cause of cryptococcal meningitis ..
  40. pmc Melanin biosynthesis in Cryptococcus neoformans
    P R Williamson
    Division of Infectious Diseases, University of Illinois at Chicago College of Medicine, 60612, USA
    J Bacteriol 180:1570-2. 1998
    Pigment production by Cryptococcus neoformans is virulence associated...
  41. pmc A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam - high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease
    Tran Th Chau
    Hospital for Tropical Diseases, Quan, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:199. 2010
    ..We describe a cohort of HIV uninfected Vietnamese patients with cryptococcal meningitis in whom underlying disease is uncommon, and relate presenting features of patients and the characteristics of the infecting species to outcome...
  42. pmc Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans
    I Russel Lee
    Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Genetics 188:309-23. 2011
    ..genetic, transcriptional, and phenotypic evidence of nitrogen metabolite repression in the human pathogen Cryptococcus neoformans. In addition to loss of transcriptional activation of catabolic enzyme-encoding genes of the uric acid ..
  43. doi Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy
    Anna Vecchiarelli
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Immunotherapy 3:997-1005. 2011
    b>Cryptococcus neoformans is an opportunistic fungal pathogen responsible for life-threatening infections in immunocompromised individuals and occasionally in those with no known immune impairment...
  44. pmc Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    J Infect Dis 195:756-64. 2007
    Variables influencing the risk of dissemination and outcome of Cryptococcus neoformans infection were assessed in 111 organ transplant recipients with cryptococcosis in a prospective, multicenter, international study...
  45. ncbi Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule
    Amy J Reese
    Department of Molecular Microbiology, Washington University School of Medicine, Campus Box 8230, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Mol Microbiol 50:1401-9. 2003
    b>Cryptococcus neoformans is an opportunistic pathogen responsible for serious disease in humans. Critical for virulence of this fungus is an elaborate polysaccharide capsule, which impedes the host immune response...
  46. pmc Cryptococcus neoformans capsular enlargement and cellular gigantism during Galleria mellonella infection
    Rocío García-Rodas
    Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS ONE 6:e24485. 2011
    We have studied infection of Cryptococcus neoformans in the non-vertebrate host Galleria mellonella with particular interest in the morphological response of the yeast. Inoculation of C...
  47. pmc Two major inositol transporters and their role in cryptococcal virulence
    Yina Wang
    Public Health Research Institute, University of Medicine and Dentistry of New Jersey, ICPH Building, Room W250H, 225 Warren Street, Newark, NJ 07103, USA
    Eukaryot Cell 10:618-28. 2011
    b>Cryptococcus neoformans is an AIDS-associated human fungal pathogen and the most common cause of fungal meningitis, with a mortality rate over 40% in AIDS patients...
  48. pmc Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection
    Aditya V Jain
    Department of Veteran s Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Infect Immun 77:5389-99. 2009
    ..However, it is not known if Cryptococcus neoformans-induced changes in lung functions are related to the immunophenotype that develops in response to ..
  49. doi The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus neoformans
    Lívia Kmetzsch
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av Bento Goncalves 9500, 43421, Caixa Postal 15005, Porto Alegre, RS 91501 970, Brazil
    Fungal Genet Biol 48:192-9. 2011
    ..b>Cryptococcus neoformans GAT1 is an ortholog to the Aspergillus nidulans AreA and Candida albicans GAT1 genes...
  50. pmc Heteroresistance of Cryptococcus gattii to fluconazole
    A Varma
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Antimicrob Agents Chemother 54:2303-11. 2010
    ..A considerably higher proportion of the C. gattii strains (86%) than Cryptococcus neoformans strains (46%) exhibited LHFs that were > or =16 microg/ml...
  51. ncbi Characterization of Cryptococcus neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence
    Srinivas D Narasipura
    Mycology Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208 2002, USA
    Mol Microbiol 55:1782-800. 2005
    We studied superoxide dismutases (SODs) in the encapsulated yeast Cryptococcus neoformans (Cn) variety gattii to analyse the role of mitochondrial MnSOD (SOD2) in fungal biology and virulence...
  52. ncbi The physical properties of the capsular polysaccharides from Cryptococcus neoformans suggest features for capsule construction
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 281:1868-75. 2006
    ..The average mass of Cryptococcus neoformans GXM from four antigenically different strains ranged from 1...
  53. pmc Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule
    Teresa R O'Meara
    Departments of Medicine and Molecular Genetics Microbiology, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Pathog 6:e1000776. 2010
    b>Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C...
  54. pmc Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms
    James A Fraser
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 2:e384. 2004
    ..These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms...
  55. ncbi Role of laccase in the biology and virulence of Cryptococcus neoformans
    Xudong Zhu
    Section of Infectious Diseases, Chicago Medical Center, University of Illinois, 808 S Wood St, Chicago, IL 60612, USA
    FEMS Yeast Res 5:1-10. 2004
    Laccase is an important virulence factor for the human pathogen, Cryptococcus neoformans. In this review, we examine the structural, biological and genetic features of the enzyme and its role in the pathogenesis of cryptococcosis...
  56. ncbi Molecular typing of clinical and environmental Cryptococcus neoformans isolates in the Brazilian state Rio Grande do Sul
    Agnes Kiesling Casali
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, P O Box 15005, 91501 970 RS, Porto Alegre, Brazil
    FEMS Yeast Res 3:405-15. 2003
    In Brazil, 4.5% of the AIDS-related opportunistic infections are caused by Cryptococcus neoformans. This pathogen is a ubiquitous environmental basidiomycetous encapsulated yeast, commonly found in soil and avian excreta...
  57. pmc Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response
    Yiorgos Apidianakis
    Department of Surgery, Massachusetts General Hospital Shriner s Burns Institute, Boston, Massachusetts 02114, USA
    Eukaryot Cell 3:413-9. 2004
    We found that the ingestion of Cryptococcus neoformans by Drosophila melanogaster resulted in the death of the fly but that the ingestion of Saccharomyces cerevisiae or the nonpathogenic Cryptococcus kuetzingii or Cryptococcus laurentii ..
  58. ncbi Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus
    Justyna Karkowska-Kuleta
    Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 56:211-24. 2009
    ..factors of the most common fungal pathogens of humans: Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. The adherence to host cells and tissues, secretion of hydrolytic enzymes, phenotypic switching and ..
  59. ncbi Iron and fungal pathogenesis: a case study with Cryptococcus neoformans
    Won Hee Jung
    The Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Cell Microbiol 10:277-84. 2008
    ..of two major virulence factors, the polysaccharide capsule and melanin, in the pathogenic fungus Cryptococcus neoformans. This pathogen, which causes meningoencephalitis in immunocompromised people, acquires iron through the ..
  60. pmc Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages
    Cara J Chrisman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Pathog 7:e1002047. 2011
    A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is a consistent increase in capsule volume. Given that many aspects of the interaction of C...
  61. pmc Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans
    Xiaorong Lin
    Department of Biology, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 6:e1000953. 2010
    b>Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and unisexual reproduction (same-sex mating)...
  62. pmc Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans
    Po Yan Cheng
    The Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 77:4284-94. 2009
    The fungal pathogen Cryptococcus neoformans causes approximately one million cases of cryptococcosis per year in people with AIDS. In contrast, the related species C...
  63. ncbi Diversity of the Cryptococcus neoformans-Cryptococcus gattii species complex
    Marjan Bovers
    Yeast Research Group, CBS Fungal Diversity Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Rev Iberoam Micol 25:S4-12. 2008
    More than 110 years of study of the Cryptococcus neoformans and Cryptococcus gattii species complex has resulted in an enormous accumulation of fundamental and applied biological and clinical knowledge...
  64. pmc A eukaryotic capsular polysaccharide is synthesized intracellularly and secreted via exocytosis
    Aki Yoneda
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 17:5131-40. 2006
    b>Cryptococcus neoformans, which causes fatal infection in immunocompromised individuals, has an elaborate polysaccharide capsule surrounding its cell wall...
  65. pmc Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier
    Caroline Charlier
    Unité de Mycologie Moléculaire, CNRS FRE2948, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Pathol 166:421-32. 2005
    b>Cryptococcus neoformans is a yeast responsible for disseminated meningoencephalitis in patients with cellular immune defects. The major virulence factor is the polysaccharide capsule...
  66. doi High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 47:123-30. 2008
    ..A dosage range for AmB of 0.7-1 mg/kg per day is noted in current guidelines, but there are no data comparing 0.7 mg/kg per day with 1 mg/kg per day...
  67. ncbi Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule
    S Shoham
    The Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4620-6. 2001
    ..We investigated whether TLRs participate in the host response to Cryptococcus neoformans glucuronoxylomannan (GXM), the major capsular polysaccharide of this fungus...
  68. pmc Cryptococcus neoformans virulence gene discovery through insertional mutagenesis
    Alexander Idnurm
    Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 3:420-9. 2004
    Insertional mutagenesis was applied to Cryptococcus neoformans to identify genes associated with virulence attributes...
  69. pmc Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways
    Young Joon Ko
    Department of Bioinformatics and Life Science, Soongsil University, Seoul, South Korea
    Eukaryot Cell 8:1197-217. 2009
    ..and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG ..
  70. pmc The capsule of the fungal pathogen Cryptococcus neoformans
    Oscar Zaragoza
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Crta Majadahonda Pozuelo, Km2, Majadahonda 28220, Madrid, Spain
    Adv Appl Microbiol 68:133-216. 2009
    The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively in recent decades and a large body of information is now available to the scientific community...
  71. pmc Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade
    Read Pukkila-Worley
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 4:190-201. 2005
    b>Cryptococcus neoformans is an opportunistic human fungal pathogen that elaborates several virulence attributes, including a polysaccharide capsule and melanin pigments...
  72. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    In the murine model of Cryptococcus neoformans infection Th1 (IL-12/IFN-gamma) and Th17 (IL-23/IL-17) responses are associated with protection, whereas an IL-4-dependent Th2 response exacerbates disease...
  73. pmc Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
    Kirsten Nielsen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 71:4831-41. 2003
    b>Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct varieties that infect most prominently the central nervous system...
  74. pmc Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi
    Xuying Wang
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Genes Dev 24:2566-82. 2010
    ..SIS), which is triggered by tandem integration of a transgene array in the human fungal pathogen Cryptococcus neoformans. A SXI2a-URA5 transgene array was found to be post-transcriptionally silenced during sexual reproduction...
  75. doi Cryptococcus neoformans: morphogenesis, infection, and evolution
    Xiaorong Lin
    Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843 3258, USA
    Infect Genet Evol 9:401-16. 2009
    b>Cryptococcus neoformans is the major causative agent of fungal meningoencephalitis in both immunocompromised and immunocompetent individuals...
  76. pmc Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection
    M Feldmesser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:4225-37. 2000
    ..Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic. To understand the mechanism by which C...
  77. ncbi Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans
    Kiwamu Nakamura
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    FEMS Immunol Med Microbiol 47:148-54. 2006
    ..study was designed to elucidate the role of Toll-like receptor (TLR) 2 and TLR4 in the host response to Cryptococcus neoformans. Both TLR2 knockout (KO) and TLR4KO mice produced interleukin-1beta (IL-1beta), IL-6, IL-12p40 and tumor ..
  78. pmc Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea
    Young Hwa Choi
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    FEMS Yeast Res 10:769-78. 2010
    ..fingerprinting and multilocus sequence typing were applied to determine the major molecular types of the Cryptococcus neoformans/Cryptococcus gattii species complex in the Republic of Korea...
  79. ncbi Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia
    Fabrice Chretien
    Laboratoire de Neuropathologie, Faculté de médecine Paris Ouest, Hopital Raymond Poincare, Garches, Paris, France
    J Infect Dis 186:522-30. 2002
    The pathogenesis of cerebral infection after Cryptococcus neoformans fungemia in outbred mice was investigated...
  80. ncbi Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway
    Kiwamu Nakamura
    Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Immunol 180:4067-74. 2008
    The mechanism of host cell recognition of Cryptococcus neoformans, an opportunistic fungal pathogen in immunocompromised patients, remains poorly understood...
  81. pmc The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response
    Oscar Zaragoza
    Departments of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 75:2729-39. 2007
    CBA/J mice were highly susceptible to intratracheal (i.t.) Cryptococcus neoformans infection relative to BALB/c mice, while both strains were equally susceptible to intravenous (i.v.) infection. Increased susceptibility in i.t...
  82. pmc Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University Medical Center, Boston, Massachusetts
    Infect Immun 67:885-90. 1999
    ..or ammonium chloride had markedly increased antifungal activity against the AIDS-related pathogen Cryptococcus neoformans. Both of these agents raise the lysosomal pH, which suggested that the increased antifungal activity was ..
  83. pmc How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans
    Tamara Lea Doering
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, USA
    Annu Rev Microbiol 63:223-47. 2009
    b>Cryptococcus neoformans is a pathogenic fungus responsible for severe opportunistic infections. The most prominent feature of this yeast is its elaborate polysaccharide capsule, a complex structure that is required for virulence...
  84. pmc Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan
    Marcio L Rodrigues
    Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941590, RJ, Brazil
    Eukaryot Cell 7:602-9. 2008
    The capsule of Cryptococcus neoformans is a complex structure whose assembly requires intermolecular interactions to connect its components into an organized structure...
  85. pmc A yeast under cover: the capsule of Cryptococcus neoformans
    Indrani Bose
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eukaryot Cell 2:655-63. 2003
  86. doi The impact of the host on fungal infections
    John R Perfect
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med 125:S39-51. 2012
    ....
  87. pmc Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence
    Marcio L Rodrigues
    Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, 21941590 Rio de Janeiro, Brazil
    Eukaryot Cell 7:58-67. 2008
    b>Cryptococcus neoformans produces vesicles containing its major virulence factor, the capsular polysaccharide glucuronoxylomannan (GXM)...
  88. pmc Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A
    Ada Rita Florio
    Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Rome, Italy
    BMC Microbiol 11:97. 2011
    ..In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress...
  89. pmc Rapid identification of Cryptococcus neoformans var. grubii, C. neoformans var. neoformans, and C. gattii by use of rapid biochemical tests, differential media, and DNA sequencing
    Lisa McTaggart
    Medical Mycology, Ontario Public Health Laboratories, Ontario Agency for Health Protection and Promotion, Department ofLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Microbiol 49:2522-7. 2011
    Rapid identification of Cryptococcus neoformans var. grubii, Cryptococcus neoformans var...
  90. pmc Characterizing the role of RNA silencing components in Cryptococcus neoformans
    Guilhem Janbon
    Unite des Aspergillus, Institut Pasteur, Paris Cedex 15, France
    Fungal Genet Biol 47:1070-80. 2010
    ..To elucidate the physiological functions of the RNAi pathway in Cryptococcus neoformans that causes fungal meningitis, here we performed genetic analyses for genes encoding Argonaute (AGO1 and ..
  91. pmc Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e26232. 2011
    Signaling via the adapter protein, MyD88, is important in the host defense against Cryptococcus neoformans infection...
  92. pmc Galactoxylomannans from Cryptococcus neoformans varieties neoformans and grubii are structurally and antigenically variable
    Magdia De Jesus
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Eukaryot Cell 9:1018-28. 2010
    Prior studies have established that the Cryptococcus neoformans capsular polysaccharide component galactoxylomannan (GalXM) manifests serotype-related structural differences that translate into antigenic differences...
  93. pmc Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin
    Jamal Stie
    Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Microbiology 158:240-58. 2012
    b>Cryptococcus neoformans can invade the central nervous system through diverse mechanisms. We examined a possible role for host plasma proteases in the neurotropic behaviour of this blood-borne fungal pathogen...
  94. pmc Evaluation of Cryptococcus neoformans galactoxylomannan-protein conjugate as vaccine candidate against murine cryptococcosis
    Siu Kei Chow
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Vaccine 29:1891-8. 2011
    Galactoxylomannan (GalXM) is a complex polysaccharide produced by the human pathogenic fungus Cryptococcus neoformans that mediates profound immunological derangements in murine models...
  95. pmc Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection
    Ambrose Jong
    Division of Hematology Oncology, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Biol Chem 287:15298-306. 2012
    b>Cryptococcus neoformans is a pathogenic yeast that can invade the brain and cause meningoencephalitis. Our previous in vitro studies suggested that the interaction between C...
  96. ncbi SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans
    Zhun Yan
    Curr Biol 14:R743-4. 2004
  97. pmc A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans
    Cheryl D Chun
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2200, USA
    Cell Host Microbe 9:243-51. 2011
    The antiphagocytic polysaccharide capsule of the human fungal pathogen Cryptococcus neoformans is a major virulence attribute...
  98. ncbi Glucuronoxylomannan exhibits potent immunosuppressive properties
    Claudia Monari
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    FEMS Yeast Res 6:537-42. 2006
    b>Cryptococcus neoformans is an opportunistic fungus responsible for life-threatening infections in immunocompromised and occasionally in immunocompetent hosts...
  99. pmc Dueling in the lung: how Cryptococcus spores race the host for survival
    Michael R Botts
    Department of Biomolecular Chemistry, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USA
    Curr Opin Microbiol 13:437-42. 2010
    ..This is particularly true for Cryptococcus neoformans, a human fungal pathogen that causes more than 600,000 deaths annually. Spores of C...
  100. pmc A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans
    Yen Ping Hsueh
    Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan
    Eukaryot Cell 4:147-55. 2005
    ..b>Cryptococcus neoformans, a bipolar human pathogenic basidiomycete, produces CAAX motif-containing lipopeptide pheromones in both ..
  101. pmc G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans
    Yen Ping Hsueh
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 18:3237-49. 2007
    ..Here we report that in the pathogenic basidiomycetous yeast Cryptococcus neoformans, two Galpha subunits (Gpa2, Gpa3) sense pheromone and govern mating...

Research Grants112 found, 100 shown here

  1. ROLE OF CALCINEURIN IN CRYPTOCOCCUS NEOFORMANS VIRULENCE
    Joseph Heitman; Fiscal Year: 2002
    ..Dr. Heitman and his group propose to elucidate signal transduction cascades regulating virulence of Cryptococcus neoformans, the leading cause of fungal meningitis and a common opportunistic infection in AIDS patients...
  2. IPC1 ROLE IN REGULATION OF PHAGOCYTOSIS OF C NEOFORMANS
    Maurizio Del Poeta; Fiscal Year: 2002
    ..of inositol-phosphoryl ceramide synthase 1 (Ipc1) in cell regulation and fungal pathogenesis, focusing on Cryptococcus neoformans. Cryptococcus neoformans is an opportunistic pathogen that primarily infects immunocompromised patients...
  3. NOVEL ANTIFUNGAL DRUG TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 2005
    ..We propose studies on both Candida albicans, the most common human fungal pathogen, and Cryptococcus neoformans, the leading cause of fungal meningitis and an important opportunistic fungal pathogen...
  4. Virulence Factor Trafficking in Cryptococcus
    Peter Williamson; Fiscal Year: 2005
    b>Cryptococcus neoformans is a major pathogen in AIDS patients causing life-threatening meningoencephalitis in a large number of HIV+ individuals...
  5. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    ..b>Cryptococcus neoformans (Cne) is an encapsulated yeast that causes often fatal cryptococcal meningoencephalitis (CM) in 7-30% of ..
  6. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2007
    b>Cryptococcus neoformans rarely causes disease among those with an intact immune system but is a very common problem among those with impaired host immunity - particularly those with AIDS...
  7. Discovery and evaluation of fungicidal anti-cryptococcal molecules
    Damian J Krysan; Fiscal Year: 2010
    b>Cryptococcus neoformans is a fungal pathogen that causes pulmonary and central nervous system infections in immunocompromised and, less commonly, immunocompetent patients...
  8. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2010
    b>Cryptococcus neoformans is a fungal pathogen that infects the human brain. The organism has a defined sexual cycle involving haploid a and a strains, and the a mating-type is linked to virulence and differentiation...
  9. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2009
    b>Cryptococcus neoformans is a fungal pathogen that infects the human brain. The organism has a defined sexual cycle involving haploid a and a strains, and the a mating-type is linked to virulence and differentiation...
  10. IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 1999
    ..proposes to study the antifungal properties of immunosuppressants in the pathogenic basidiomycete Cryptococcus neoformans, whose incidence has risen, especially in HIV infection, to become the leading cause of fungal meningitis...
  11. ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITING
    Joseph Heitman; Fiscal Year: 2005
    ..Our studies define signal transduction cascades regulating physiology and virulence of the pathogen Cryptococcus neoformans. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin block signaling cascades required for T-..
  12. Pathogenesis of Cryptococcus Spores
    Christina M Hull; Fiscal Year: 2010
    Our goal is to define the molecular mechanisms that control interactions between Cryptococcus neoformans and the mammalian immune system in an effort to ultimately prevent and treat fungal disease...
  13. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2009
    b>Cryptococcus neoformans rarely causes disease among those with an intact immune system but is a very common problem among those with impaired host immunity - particularly those with AIDS...
  14. Cell wall biogenesis in Cryptococcus neoformans
    Deborah Fox; Fiscal Year: 2004
    ..However, they have very low potency against Cryptococcus neoformans, a medically significant fungal pathogen...
  15. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2007
    ..The genome project for the human fungal pathogen Cryptococcus neoformans has provided the complete genome for the serotype D strain (JEC20), generated 10 to 12X assemblies for ..
  16. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..The genome project for the human fungal pathogen Cryptococcus neoformans has provided the complete genome for the serotype D strain (JEC20), generated 10 to 12X assemblies for ..
  17. IMMUNE RESPONSE TO CRYPTOCOCCAL INFECTIONS
    Stuart M Levitz; Fiscal Year: 2010
    b>Cryptococcus neoformans is a major cause of morbidity and mortality in persons with T cell dysfunction, particularly AIDS. Mannoproteins (MP) are the primary component recognized by the anticryptococcal T cell-mediated immune response...
  18. Role of Ipc1 in fungal pathogenesis
    Maurizio Del Poeta; Fiscal Year: 2003
    ..and functions of sphingolipids in cell regulation and pathogenesis, focusing on the opportunistic fungus Cryptococcus neoformans. This fungal pathogen mainly infects immunocompromised patients, and it is the most common cause of ..
  19. Functions of Cryptococcus neoformans mating type loci
    Joseph Heitman; Fiscal Year: 2006
    b>Cryptococcus neoformans is a fungal pathogen that infects the human brain. The organism has a defined sexual cycle involving haploid MATalpha and MATa strains, and the MATalpha locus has been linked to virulence and differentiation...
  20. The Role of Unc119 in T Cell Antigen Receptor Signaling1
    Peter Williamson; Fiscal Year: 2003
    Description (Adapted from Abstract): Cryptococcus neoformans is a major pathogen in immunocompromised patients, causing life-threatening meningoencephalitis in approximately 6% of HIV positive individuals...
  21. MATING TYPE AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANS
    Brian Wickes; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Cryptococcus neoformans is a basidiomycetous fungus which can cause life threatening infections...
  22. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2007
    Our studies have defined signaling cascades regulating Cryptococcus neoformans differentiation and virulence...
  23. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    Our studies have defined signaling cascades regulating Cryptococcus neoformans differentiation and virulence...
  24. SUPEROXIDE DISMUTASE OF CRYPTOCOCCUS NEOFORMANS
    Sudha Chaturvedi; Fiscal Year: 2004
    DESCRIPTION: Cryptococcus neoformans (Cn), a facultative intracellular yeast, is a serious cause of meningoencephalitis in normal and immunocompromised patients...
  25. Light-regulated genes affecting the pathogen potential of Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2007
    ..inhibition of mating by light, tolerance to UV irradiation, and virulence in the human pathogenic fungus Cryptococcus neoformans. However, it is unclear what genes are regulated by light via Bwc1-Bwc2...
  26. LACCASE REGULATION AND VIRULENCE IN CRYPTOCOCCUS
    James Cook; Fiscal Year: 2009
    b>Cryptococcus neoformans is a major pathogen in immunocompetent as well as immunocompromised patients including those with AIDS in both the developed as well as the developing world...
  27. MECHANISM OF ANTIBODY PROTECTION AGAINST C. NEOFORMANS
    Sherie Morrison; Fiscal Year: 2003
    b>Cryptococcus neoformans causes a lethal meningoencephalitis in 8 percent of AIDS patients in the US...
  28. MECHANISM OF ANTIBODY PROTECTION AGAINST C. NEOFORMANS
    Sherie Morrison; Fiscal Year: 2007
    b>Cryptococcus neoformans causes a lethal meningoencephalitis in 8% of AIDS patients in the US...
  29. MECHANISM OF ANTIBODY PROTECTION AGAINST C. NEOFORMANS
    Sherie Morrison; Fiscal Year: 2006
    b>Cryptococcus neoformans causes a lethal meningoencephalitis in 8 percent of AIDS patients in the US...
  30. T CELLS AND IMMUNITY TO CRYPTOCOCCOSIS
    JUNEANN MURPHY; Fiscal Year: 2003
    ..abstract): Cryptococcosis is a life-threatening disease caused by the ubiquitous, encapsulated fungus, Cryptococcus neoformans. Although individuals with T cell deficiencies are the most susceptible group for this disease, normal ..
  31. Sexual development in Cryptococcus neoformans
    CHRISTINA HULL; Fiscal Year: 2009
    ..molecular mechanisms by which sexual development is controlled in the opportunistic human fungal pathogen Cryptococcus neoformans. Sexual development results in the production of spores that can be dispersed into the environment. C...
  32. Oxidative and nitrosative stress resistance of Cryptococcus neoformans
    Jennifer K Lodge; Fiscal Year: 2010
    ..essential for resistance to oxidative and nitrosative stress, and iii) is important for the virulence of Cryptococcus neoformans. There are three interrelated, yet independent, specific aims in this application that will further ..
  33. Oxidative and nitrosative stress resistance of Cryptococcus neoformans
    JENNIFER LODGE; Fiscal Year: 2007
    ..essential for resistance to oxidative and nitrosative stress, and iii) is important for the virulence of Cryptococcus neoformans. There are three interrelated, yet independent, specific aims in this application that will further ..
  34. PATHOGENESIS OF CRYPTOCOCCAL MENINGOENCEPHALITIS
    Sunhee Lee; Fiscal Year: 2002
    DESCRIPTION: (Adapted from Applicant's Abstract) Cryptococcal meningoencephalitis is caused by Cryptococcus neoformans, an encapsulated fungus which is ubiquitous in urban environments...