mitosporic fungi

Summary

Summary: A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.

Top Publications

  1. ncbi Antibacterial and antifungal activity of Senecio inaequidens DC. and Senecio vulgaris L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 18:777-9. 2004
  2. ncbi Antifungal activity of the stem bark of Ailanthus excelsa
    B C Joshi
    Chemistry Department, Lucknow University, Lucknow, India
    Fitoterapia 74:689-91. 2003
  3. ncbi Fungal pathogen reduces potential for malaria transmission
    Simon Blanford
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT Scotland, UK
    Science 308:1638-41. 2005
  4. doi Intraspecific traits change biodiversity effects on ecosystem functioning under metal stress
    Isabel Fernandes
    Centre of Molecular and Environmental Biology CBMA, Department of Biology, University of Minho, Braga, Portugal
    Oecologia 166:1019-28. 2011
  5. pmc Determining diversity of freshwater fungi on decaying leaves: comparison of traditional and molecular approaches
    Liliya G Nikolcheva
    Department of Biology, Mount Allison University, 63B York Street, Sackville, New Brunswick, Canada E4L 1G7
    Appl Environ Microbiol 69:2548-54. 2003
  6. ncbi Aquatic hyphomycete diversity and identity affect leaf litter decomposition in microcosms
    Sofia Duarte
    Department of Biology, Minho University, Campus de Gualtar, 4710 057 Braga, Portugal
    Oecologia 147:658-66. 2006
  7. ncbi Virulence of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes) on Anastrepha ludens (Diptera: Tephritidae): laboratory and field trials
    R Lezama-Gutierrez
    Facultad de Ciencias Biológicas y Agropecuarias de la Universidad de Colima, Tecomán, Mexico
    J Econ Entomol 93:1080-4. 2000
  8. doi Elevated aluminium concentration in acidified headwater streams lowers aquatic hyphomycete diversity and impairs leaf-litter breakdown
    J M Baudoin
    Laboratoire Interactions Ecotoxicité, Biodiversité, Ecosystèmes, UMR CNRS 7146, Universite Paul Verlaine Metz, Delestraint, 57070, Metz, France
    Microb Ecol 56:260-9. 2008
  9. doi Fungi in freshwaters: ecology, physiology and biochemical potential
    Gerd Joachim Krauss
    Faculty I of Natural Science Biological Science, Institute of Biochemistry and Biotechnology, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    FEMS Microbiol Rev 35:620-51. 2011
  10. pmc Intraspecific variation of the aquatic fungus Articulospora tetracladia: an ubiquitous perspective
    Sahadevan Seena
    Department of Biology, Centre of Molecular and Environmental Biology CBMA, University of Minho, Braga, Portugal
    PLoS ONE 7:e35884. 2012

Research Grants

Detail Information

Publications180 found, 100 shown here

  1. ncbi Antibacterial and antifungal activity of Senecio inaequidens DC. and Senecio vulgaris L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 18:777-9. 2004
    ..and Senecio vulgaris L. were assayed. The hexane extract of Senecio vulgaris L. (MIC 0.031 mg/ml) showed significant activity against Trichophyton tonsurans...
  2. ncbi Antifungal activity of the stem bark of Ailanthus excelsa
    B C Joshi
    Chemistry Department, Lucknow University, Lucknow, India
    Fitoterapia 74:689-91. 2003
    ..The chloroform extract showed fungistatic and fungicidal activity against Aspergillus niger, A. fumigatus, Penicillium frequentence, P. notatum and Botrytis cinerea...
  3. ncbi Fungal pathogen reduces potential for malaria transmission
    Simon Blanford
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT Scotland, UK
    Science 308:1638-41. 2005
    ..Residual sprays of fungal biopesticides might replace or supplement chemical insecticides for malaria control, particularly in areas of high insecticide resistance...
  4. doi Intraspecific traits change biodiversity effects on ecosystem functioning under metal stress
    Isabel Fernandes
    Centre of Molecular and Environmental Biology CBMA, Department of Biology, University of Minho, Braga, Portugal
    Oecologia 166:1019-28. 2011
    ..These findings emphasize the importance of intraspecific diversity in modulating diversity effects under metal stress, providing evidence that trait-based diversity measures should be incorporated when examining biodiversity effects...
  5. pmc Determining diversity of freshwater fungi on decaying leaves: comparison of traditional and molecular approaches
    Liliya G Nikolcheva
    Department of Biology, Mount Allison University, 63B York Street, Sackville, New Brunswick, Canada E4L 1G7
    Appl Environ Microbiol 69:2548-54. 2003
    ..Since traditional and molecular techniques assess different aspects of the fungal organism, both are essential for a balanced view of fungal succession on leaves decaying in streams...
  6. ncbi Aquatic hyphomycete diversity and identity affect leaf litter decomposition in microcosms
    Sofia Duarte
    Department of Biology, Minho University, Campus de Gualtar, 4710 057 Braga, Portugal
    Oecologia 147:658-66. 2006
    ..Our results also suggest that specific traits of certain species may have a greater influence on ecosystem functioning than species number...
  7. ncbi Virulence of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes) on Anastrepha ludens (Diptera: Tephritidae): laboratory and field trials
    R Lezama-Gutierrez
    Facultad de Ciencias Biológicas y Agropecuarias de la Universidad de Colima, Tecomán, Mexico
    J Econ Entomol 93:1080-4. 2000
    ..M. anisopliae may offer a preferable alternative to chemicals as a biological control agent against A. ludens...
  8. doi Elevated aluminium concentration in acidified headwater streams lowers aquatic hyphomycete diversity and impairs leaf-litter breakdown
    J M Baudoin
    Laboratoire Interactions Ecotoxicité, Biodiversité, Ecosystèmes, UMR CNRS 7146, Universite Paul Verlaine Metz, Delestraint, 57070, Metz, France
    Microb Ecol 56:260-9. 2008
    ..Leaf breakdown rate was drastically reduced under acidic conditions raising the issue of whether the functioning of headwater ecosystems could be impaired by a loss of aquatic hyphomycete species...
  9. doi Fungi in freshwaters: ecology, physiology and biochemical potential
    Gerd Joachim Krauss
    Faculty I of Natural Science Biological Science, Institute of Biochemistry and Biotechnology, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    FEMS Microbiol Rev 35:620-51. 2011
    ..The same capabilities occur in freshwater fungi. This suggests a largely ignored role of these organisms in attenuating pollutant loads in freshwaters and their potential use in environmental biotechnology...
  10. pmc Intraspecific variation of the aquatic fungus Articulospora tetracladia: an ubiquitous perspective
    Sahadevan Seena
    Department of Biology, Centre of Molecular and Environmental Biology CBMA, University of Minho, Braga, Portugal
    PLoS ONE 7:e35884. 2012
    ..tetracladia genotypes were geographically widespread irrespective of sampling time, sites or substrates. Furthermore, PCR-DGGE appeared to be a rapid tool for assessing intraspecific diversity of aquatic hyphomycetes...
  11. ncbi Molecular evidence confirms multiple origins of aquatic hyphomycetes
    Michel J R Belliveau
    Department of Biology, Mount Allison University, Sackville, New Brunswick E4L 1G7, Canada
    Mycol Res 109:1407-17. 2005
    ..The nSSU rDNA sequences of several species were identical (e.g. Anguillospora crassa and A. furtiva), suggesting the need to include less conservative genes for resolving such differences...
  12. ncbi Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil
    A K Gupta
    Division of Dermatology, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 40:529-34. 2002
    ..Some success with alternative week therapy was also noted in one patient. The favorable response and lack of significant adverse effects suggests that these regimens may be an option for some patients with chromoblastomycosis...
  13. ncbi Antifungal activities of five Combretaceae used in Togolese traditional medicine
    K Batawila
    Laboratory of Botany and Plant Ecology, Research and Education Centre for Medicinal Plants, University of Lome, P O Box 1515, Lome, Togo
    Fitoterapia 76:264-8. 2005
    ..25 mg/ml to 4 mg/ml. The results confirm the traditional therapeutic properties of these plants...
  14. ncbi Antimicrobial activity of Chenopodium botrys essential oil
    Zoran A Maksimović
    Institute of Pharmacognosy, School of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia and Montenegro
    Fitoterapia 76:112-4. 2005
    ..Essential oil, isolated by hydrodistillation from Chenopodium botrys aerial parts, expressed significant bactericidal and fungicidal activity against selected strains of microorganisms...
  15. ncbi Color versus bioactivity in the flowers of Bougainvillea spectabilis (Nyctaginaceae)
    Muhammad Shaiq Ali
    H E J Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:1-5. 2005
    ..The extract of white flowers also exhibits toxicity against shrimp larvae with a LD50 value of 33.5627 microg/mL. However, none of the tested samples gave positive responses against any tested fungi...
  16. ncbi A novel pentacyclic triterpene from Leontodon filii
    Zélia Tostão
    Departamento de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal
    Fitoterapia 76:173-80. 2005
    ..The fungicidal efficacy of the chloroform and methanol extracts of the plant was also evaluated, a protective effect being found against Plasmopara viticola, Botrytis cinerea, particularly powerful against Pyricularia oryzae...
  17. ncbi Antifungal activity of Rubia tinctorum, Rhamnus frangula and Caloplaca cerina
    N T Manojlovic
    Faculty of Science, University of Kragujevac, P O Box 60, 34000 Kragujevac, Serbia and Montenegro
    Fitoterapia 76:244-6. 2005
    ....
  18. ncbi Antifungal activity of Cynara scolymus L. extracts
    X F Zhu
    Research Center for Eco Environmental Sciences and Graduate School, Chinese Academy of Sciences, Beijing 100085, China
    Fitoterapia 76:108-11. 2005
    ..leaves, heads and stems were tested for their antifungal activity using the agar-well diffusion assay technique. The leaves extracts and the ethanol fractions were found to be the most effective extract against all the tested organisms...
  19. ncbi Studies on the bioactivity and elementology of marine algae from the coast of Karachi, Pakistan
    Muhammad Afzal Rizvi
    Hamdard Institute of Advanced Studies and Research, Hamdard University, Karachi, Pakistan
    Phytother Res 18:865-72. 2004
    ..Among them Ca, Cr and Pb were found to occur in largest amount in green seaweeds, Co, Cu, Fe and Zn in greatest quantity in brown seaweeds, while Cd, K, Mg and Na in highest proportion in the investigated red seaweeds...
  20. ncbi A novel bioactive flavonol glycoside from Teramnus labialis spreng
    R N Yadava
    Department of Chemistry, Natural Products Laboratory, Dr H S Gour University, Sagar M P 470003, India
    Nat Prod Res 18:537-42. 2004
    ..The chloroform extract of compound (1) showed antibacterial and antifungal activities...
  21. ncbi Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia
    C Wiart
    Department of Pharmacy, University of Malaya, Malaysia
    Fitoterapia 75:68-73. 2004
    ....
  22. ncbi Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea
    P K Chaudhuri
    Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India
    Phytother Res 18:114-7. 2004
    ..The structures of the compounds were established by spectral and chemical studies...
  23. ncbi Phyllanthus piscatorum, ethnopharmacological studies on a women's medicinal plant of the Yanomamï Amerindians
    Jürg Gertsch
    Swiss Federal Institute of Technology Zurich, Institute of Pharmaceutical Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Ethnopharmacol 91:181-8. 2004
    ....
  24. ncbi Antimicrobial activity of Memecylon malabaricum leaves
    Kiran Kumar Hullatti
    Department of Applied Botany and Biotechnology, University of Mysore, Manasagangotri, Mysore 570 006, India
    Fitoterapia 75:409-11. 2004
    ..The petroleum ether, chloroform and methanol extracts of Memecylon malabaricum leaves were tested for antimicrobial activity. Only methanol extract has shown activity against bacteria both Gram (+) and Gram (-), and fungi...
  25. ncbi Antibacterial and antifungal activities of Euroschinus papuanus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:412-6. 2004
    ..Excellent activity was demonstrated by the E fractions of stem heart wood, D of root bark, and E of root heart wood. Antifungal activity was exhibited by the B fractions of leaves, stem heartwood and root bark...
  26. ncbi Antibacterial and antifungal activities of Quassia undulata and Quassia amara extracts in vitro
    E O Ajaiyeoba
    Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 32:353-6. 2003
    ..0-29.0 mm for the tested extracts/drugs. All the extracts have shown impressive activities against the commonly encountered microorganisms and have thus confirmed the folklore uses of the plants in the African ethnomedicine...
  27. ncbi Antibacterial activity of Galeola foliata
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:494-6. 2004
    ..A broad spectrum antibacterial activity (24 bacteria and protozoan) was exhibited by both parts. A very good level of activity was demonstrated by the CH2Cl2 and EtOAc fractions. None of the fractions were active against the moulds...
  28. ncbi Antifungal properties of Pseudarthria viscida
    M A Deepa
    Department of Botany, Bharathiar University, Coimbatore, Tamilnadu 46, India
    Fitoterapia 75:581-4. 2004
    ..The extracts of leaf, root, stem, and the callus obtained from Pseudarthria viscida showed significant inhibitory activity against some fungal pathogens causing major diseases in crop plants and stored food grains...
  29. ncbi Antifungal activity of steroidal glycosides from Yucca gloriosa L
    A Favel
    Laboratory of Botany and Cryptogamy, Faculty of Pharmacy, Marseille, France
    Phytother Res 19:158-61. 2005
    ..78 and 12.5 microg[sol ]mL. The most sensitive filamentous species was A. fumigatus (MIC = 1.56 microg[sol ]mL). For most of the strains, the MICs of both glycosides were similar to those of the reference antifungal agent...
  30. ncbi Antifungal properties of surangin B, a coumarin from Mammea longifolia
    Yanshen Deng
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Planta Med 71:364-5. 2005
    ..3 microM) and Botrytis cinerea (IC50 = 1.4 microM), although Alternaria dauci was considerably more tolerant of this coumarin (IC50 = 500 microM). Our results indicate that surangin B may have potential as an antifungal agent...
  31. ncbi Antimicrobial synergism and antagonism of salicylaldehyde in Filipendula vulgaris essential oil
    N Radulovic
    Department of Chemistry, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Fitoterapia 78:565-70. 2007
    ..The maximum (negative) interaction was shown to correspond approximately to the mixture at the 40:60 (methyl salicylate/salicylaldehyde) mol ratio resulting in the complete loss of activity at the investigated dose...
  32. ncbi Antimicrobial activities of Indian Berberis species
    Meenakshi Singh
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226001, India
    Fitoterapia 78:574-6. 2007
    ..B. aristata root extract gave low MICs values against Bacillus cereus, Escherichia coli, Staphylococcus aureus and Aspergillus flavus while stem extract against B. cereus and Streptococcus pneumoniae...
  33. ncbi Suppression of phytopathogenic fungi by hexane extract of Nepenthes ventricosa x maxima leaf
    Kwang Soo Shin
    Department of Microbiology, Daejeon University, Daejeon 300 716, Republic of Korea
    Fitoterapia 78:585-6. 2007
    ..stolonifer and Sclerotinia sclerotiorum...
  34. ncbi Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa
    Eui Il Hwang
    KT and G Central Research Institute, Daejeon, Korea
    Planta Med 73:679-82. 2007
    ..The results indicate that these compounds are specific inhibitors of chitin synthase 2 and can potentially serve as antifungal agents...
  35. ncbi Antimicrobial activity of four species of Berberidaceae
    Ai Rong Li
    School of Life Science, Nanjing University, Nanjing, China
    Fitoterapia 78:379-81. 2007
    ..Most of the extracts have been proved to be active against Gram(+) bacteria...
  36. ncbi In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)
    J P Dzoyem
    Laboratory of Mycology, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon
    Phytother Res 21:671-4. 2007
    ..Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent...
  37. ncbi Antifungal activity of Aloe vera leaves
    Oana Rosca-Casian
    Department of Biology, Faculty of Biology and Geology, Babes Bolyai University, 42 Republicii Street, 400015 Cluj Napoca, Romania
    Fitoterapia 78:219-22. 2007
    ..sp. gladioli, Heterosporium pruneti and Penicillium gladioli on Czapek-agar medium. The minimum fungicidal concentration (MFC) varied between 80 and 100 microl/ml, depending on the fungal species...
  38. ncbi Antimicrobial and cytotoxic activities of Achyranthes ferruginea
    M Mukhlesur Rahman
    Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
    Fitoterapia 78:260-2. 2007
    ..Both crude extract (CE) and compound 1 showed significant cytotoxicity of LC(50) at 16.21 microg/ml and 11.70 microg/ml, respectively...
  39. ncbi Chemical composition and antimicrobial activity of Chamaecyparis obtusa leaf essential oil
    Jae Kyung Yang
    Faculty of Forest Science and Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 660 701, Republic of Korea
    Fitoterapia 78:149-52. 2007
    ..alpha-Terpinyl acetate, sabinene, isobornyl acetate and limonene were found to be the major components. The oil showed relatively strong antibacterial activities against Gram (+) bacteria and some fungi...
  40. ncbi Antimicrobial activity of some Indian mosses
    Meenakshi Singh
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226001, India
    Fitoterapia 78:156-8. 2007
    ..Sphagnum junghuhnianum, Barbula javanica, Barbula arcuata, Brachythecium populeum, Brachythecium rutabulum, Mnium marginatum and Entodon cf rubicundus were found to be most active against all the organisms...
  41. ncbi Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark
    Renato Bruni
    Dipartimento di Biologia Evolutiva e Funzionale, Parco Area delle Scienze 11, 43100 Parma, Italy
    Fitoterapia 77:538-45. 2006
    ..The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum...
  42. ncbi New and bioactive aromatic compounds from Zanthoxylum zanthoxyloides
    Emerson F Queiroz
    Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie Genève Lausanne, Universite de Geneve, Geneve, Switzerland
    Planta Med 72:746-50. 2006
    ..The structures of the isolated compounds were elucidated by classical spectroscopic methods including UV, NMR, MS and HR-MS...
  43. ncbi Biological activity of Spatoglossum asperum: a brown alga
    Jehan Ara
    Department of Food Science and Technology, University of Karachi, Karachi 75270, Pakistan
    Phytother Res 19:618-23. 2005
    ..Oily fractions of S. asperum also showed hypolipidaemic activity in normal, triton-induced and high fat diet-induced hyperlipidaemic rats without producing any ill effect on cardiac and liver enzymes...
  44. ncbi Antimicrobial activity of Pycnogenol
    Maria Angeles Calvo Torras
    Veterinary Faculty, University Autonomous of Barcelona, Spain
    Phytother Res 19:647-8. 2005
    ..025% could counteract the growth of all the strains investigated in our study. These results conform with clinical oral health care studies describing the prevention of plaque formation and the clearance of candidiasis by Pycnogenol...
  45. ncbi Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill
    N F A Bafi-Yeboa
    Department of Biology, University of Ottawa, Ottawa, Ont, Canada K1N 6N5
    Phytomedicine 12:370-7. 2005
    ..902, p<0.001). The results provide a phytochemical basis for the very widespread use of Z. americanum in indigenous North American ethnomedical tradition for conditions that may be related to fungal infections...
  46. ncbi Antifungal activities of six South African Terminalia species (Combretaceae)
    P Masoko
    Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa
    J Ethnopharmacol 99:301-8. 2005
    ..0.08 mg/ml, some were with MIC values as low as 0.02 mg/ml. Microsporum canis was the most susceptible microorganism and Terminalia sericea extracts were the most active against nearly all microorganisms tested...
  47. ncbi Antifungal activity of Zuccagnia punctata Cav.: evidence for the mechanism of action
    Laura Svetaz
    Farmacognosia, Facultad Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina
    Planta Med 73:1074-80. 2007
    ....
  48. ncbi Antifungal activity of wogonin
    Mahesh Pal
    Department of Phytochemistry, National Botanical Research Institute, Lucknow 226001, India
    Phytother Res 17:1215-6. 2003
    ..notatum and Botrytis cinerea, in a concentration dependent fashion, when tested by turbidity and spore germination methods. The effects produced by the compound were compared with the standard antifungal agent griseofulvin...
  49. ncbi Antibacterial activity of Artocarpus heterophyllus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, PMB, Lae, Papua New Guinea
    Fitoterapia 74:501-5. 2003
    ..The butanol fractions of the root bark and fruits were found to be the most active. None of the fractions were active against the fungi tested...
  50. ncbi Antibacterial activity of Pterocarpus indicus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, PMB, Lae, Papua New Guinea
    Fitoterapia 74:603-5. 2003
    ..All the fractions exhibited a wide spectrum of antibacterial activity. The activity was more pronounced in the butanol and methanol fractions. None were active against the moulds...
  51. ncbi Antibacterial and antifungal activity of Erigeron breviscapus
    H Liu
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Fitoterapia 74:387-9. 2003
    ..The antibacterial and antifungal properties of the ethanol extract of Erigeron breviscapus whole plant was evaluated. The extract showed a moderate antibacterial activity and a high antifungal activity...
  52. ncbi Antimicrobial and antioxidant activities of three Mentha species essential oils
    Neda Mimica-Dukic
    University of Novi Sad, Faculty of Natural Sciences and Mathematics, Department of Chemistry, Novi Sad, FR Yugoslavia
    Planta Med 69:413-9. 2003
    ..longifolia and M. piperita and 1,8-cineole in the oil of M. aquatica...
  53. ncbi Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana
    V L Niranjan Reddy
    Natural Products Laboratory, Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Fitoterapia 74:600-2. 2003
    ..Compound 1 showed activity against this fungus...
  54. ncbi Antibacterial and antifungal activity of Indonesian ethnomedical plants
    E Goun
    Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA
    Fitoterapia 74:592-6. 2003
    ..Tylophora asthmatica and Hyptis brevipes demonstrated high activity in this bioassay system. These findings should stimulate the search for novel, natural product such as new antibacterial and antifungal agents...
  55. ncbi Antifungal compounds from Zanthoxylum chiloperone var. angustifolium
    Céline Thouvenel
    Laboratoire de Pharmacognosie UPRES A 8076 CNRS BIOCIS, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    Phytother Res 17:678-80. 2003
    ..interdigitale with MICs values between 5.3 and 46 micro mol/L. 5-methoxy-canthin-6-one was active against only Trichophyton mentagrophytes var. interdigitale with a MIC value of 12.3 micro mol/L...
  56. ncbi Zaluzanin D: a fungistatic sesquiterpene from Vernonia arborea
    G N Krishna Kumari
    Centre for Natural Products, SPIC Science Foundation, SPIC House, 88 Mount Road, Chennai 600 032, India
    Fitoterapia 74:479-82. 2003
    ..Zaluzanin D, a sesquiterpene lactone has been isolated from the aerial parts of Vernonia arborea as a major constituent (0.04%). Antifungal activity of zaluzanin D has been studied against six plant-pathogenic fungi...
  57. ncbi Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids
    Anna Vollekova
    Mycological Laboratory, Department of Dermatovenerology, Slovak Postgraduate Academy of Medicine, Bratislava, Slovakia
    Phytother Res 17:834-7. 2003
    ..5 to >100 micro g/mL. Our results suggest that jatrorrhizine may serve as a leading compound for further studies to develop new antifungal agents with highly potent antifungal activity and low host toxicity...
  58. ncbi Antifungal activity of some Cuban Zanthoxylum species
    R Diéguez-Hurtado
    Centro de Química Farmacéutica, Calle 200 y 21, Atabey, Playa, Ciudad de La Habana, Cuba
    Fitoterapia 74:384-6. 2003
    ..Ethanolic extracts of the trunk bark of Zanthoxylum fagara, Z. elephantiasis and Z. martinicense showed activity against different species of fungi. No antibacterial activity was detected...
  59. ncbi Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth
    B Singh
    Department of Botany, University of Rajasthan, Jaipur, India
    Phytother Res 17:814-6. 2003
    ..39) against E. coli and hexacosanoic acid had greater activity against A. flavus (IZ = 11.56). The present study deals with antimicrobial screening of sequential extracts and isolated terpenoids...
  60. ncbi Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum
    K Morteza-Semnani
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Fitoterapia 74:493-6. 2003
    ..Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant...
  61. ncbi Antimicrobial activity of some Hypericum species
    R Dall'agnol
    Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, RS, Brazil
    Phytomedicine 10:511-6. 2003
    ..perforatum, which has high concentrations of rutin, these species do not produce this flavonoid or it appears as traces. The tannin concentration varied between 5.1 and 16.7% in H. myrianthum and H. ternum, respectively...
  62. ncbi Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens
    A Vonshak
    Ben Gurion University of the Negev, Jacob Blaustein Institute for Desert Research, Albert Katz Department of Dryland Biotechnologies, Desert Plant Biotechnology Laboratory, Sede Boqer Campus, 84990, Israel
    Phytother Res 17:1123-5. 2003
    ..chebula. Chebulinic acid, a known tannin of T. chebula was tested and found not inhibitory, thus a search for the active compound is needed...
  63. ncbi Antimicrobial activity of Toona ciliata and Amoora rohituka
    Rasheduzzaman Chowdhury
    Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
    Fitoterapia 74:155-8. 2003
    ..ciliata, exhibited significant in vitro antibacterial activity. The extracts also demonstrated mild antifungal effect...
  64. ncbi Two new benzofuranes from Eupatorium aschenbornianum and their antimicrobial activity
    Maria Yolanda Rios
    Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
    Planta Med 69:967-70. 2003
    ..5 microg/mL ( T. mentagrophytes), 12.5 microg/mL ( T. rubrum), 100 microg/mL ( C. albicans) and 200 microg/mL ( A. niger)]...
  65. ncbi Pharmacological and toxicological activity of Heterophyllaea pustulata anthraquinone extracts
    S C Núñez Montoya
    Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Quimicas, UNC, Instituto Multidisciplinario de Biología Vegetal IMBiV CONICET, Cordoba, Argentina
    Phytomedicine 10:569-74. 2003
    ..Acute toxicity studies revealed a low toxicity in mice for the anthraquinonic extracts, as measured in the LD50 value (123 mg/kg body wt. i.v.), and death was not observed at doses of up to 4000 mg/kg body wt. s.c...
  66. ncbi Bioassay-guided isolation and identification of antifungal compounds from ginger
    C Ficker
    Ottawa Carleton Institutes of Biology and Chemistry, Carleton University and University of Ottawa, Ottawa ON, Canada
    Phytother Res 17:897-902. 2003
    ..Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy...
  67. ncbi Antimicrobial activity of Ximenia americana
    M E F A Omer
    Medicinal and Aromatic Plants Research Institute, National Centre for Research, PO Box 2404, Khartoum, Sudan
    Fitoterapia 74:122-6. 2003
    ..Extracts of the bark, leaves, root and stem of Ximenia americana were tested for their antimicrobial and antifungal activity...
  68. ncbi Composition and antimicrobial activity of Achillea clavennae L. essential oil
    Nada Bezić
    University of Split, Faculty of Natural Science, Mathematics and Education, Department of Biology, Teslina 12, 21000 Split, Croatia
    Phytother Res 17:1037-40. 2003
    ..A. clavennae oil was found to possess antimicrobial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa and all fungal organisms...
  69. ncbi New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth
    Hong Wei Liu
    Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
    J Asian Nat Prod Res 5:241-7. 2003
    ..Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro...
  70. ncbi Filamentous fungi associated with holothurians from the sea of Japan, off the primorye coast of Russia
    M V Pivkin
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia
    Biol Bull 198:101-9. 2000
    ..Twenty-seven species of marine fungi, mostly facultative ones belonging to the mitosporic fungi, were isolated from the holothurians and identified...
  71. ncbi Concentration and species diversity of airborne fungi near busy streets in Lithuanian urban areas
    Albinas Lugauskas
    Institute of Botany, Laboratory of Biodeterioration Research, Zaliuju ezeru 49, LT 2021 Vilnius, Lithuania
    Ann Agric Environ Med 10:233-9. 2003
    ..b>Mitosporic fungi comprised 138 genera, 358 species, and comprised the vast majority of identified species: 358 out of 430 (83...
  72. ncbi Stromata, sporangiomata and chlamydosori of Phytophthora ramorum on inoculated Mediterranean woody plants
    Eduardo Moralejo
    Institut Mediterrani d Estudis Avançats, IMEDEA CSIC UIB Miquel Marquès 21, 07190 Esporles, Balearic Islands, Spain
    Mycol Res 110:1323-32. 2006
    ..Sporangiomata bore short sporangiophores and clusters of 20-100 sporangia and resembled sporodochia of the mitosporic fungi. The biological significance of these multihyphal structures is discussed...
  73. pmc Cyclic GMP as a second messenger in the nitric oxide-mediated conidiation of the mycoparasite Coniothyrium minitans
    Bo Li
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei Province, People s Republic of China
    Appl Environ Microbiol 76:2830-6. 2010
    Understanding signaling pathways that modulate conidiation of mitosporic fungi is of both practical and theoretical importance...
  74. ncbi L-arginine is essential for conidiation in the filamentous fungus Coniothyrium minitans
    Xiaoyan Gong
    The Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China
    Fungal Genet Biol 44:1368-79. 2007
    Conidiation is important in the life cycles of mitosporic fungi for survival and transmission...
  75. ncbi Pine nuts: the mycobiota and potential mycotoxins
    M Weidenbörner
    Institut fur Angewandte Mikrobiologie, Heinrich Buff Ring, Giessen, Germany
    Can J Microbiol 47:460-3. 2001
    ..In total, 1832 fungi belonging to 31 species and 15 genera (Ascomycota, 2; Zygomycota, 3; mitosporic fungi, 10) could be isolated. Cladosporium spp...
  76. pmc Isolation and characterisation of polychlorinated biphenyl (PCB) degrading fungi from a historically contaminated soil
    Valeria Tigini
    Department of Plant Biology, University of Turin, Viale Mattioli 25, 10125 Turin, Italy
    Microb Cell Fact 8:5. 2009
    ..abstract:..
  77. ncbi Biotransformation of the polycyclic musks HHCB and AHTN and metabolite formation by fungi occurring in freshwater environments
    Claudia Martin
    UFZ, Department of Environmental Microbiology, Leipzig, Germany
    Environ Sci Technol 41:5395-402. 2007
    ..strain UHH 1-13-18-4 and Clavariopsis aquatica, two mitosporic fungi derived from freshwater environments...
  78. doi A comparative account of backwater and brackish water marine mycoflora of North Malabar (Kerala) India
    Gayatri R Nambiar
    Department of P G Studies and Research in Botany, Sir Syed College, Taliparamba, Kerala, India
    C R Biol 331:294-7. 2008
    ..A total of 30 marine fungi were isolated, which include 19 Ascomycetes, 1 Basidiomycete, and 10 Mitosporic fungi. Periconia prolifica emerged as the most dominant one in terms of percent frequency of occurrence and percent ..
  79. doi The ectopic expression of a pectin methyl esterase inhibitor increases pectin methyl esterification and limits fungal diseases in wheat
    Chiara Volpi
    Department of Agrobiology and Agrochemistry, University of Tuscia, Viterbo, Italy
    Mol Plant Microbe Interact 24:1012-9. 2011
    ..In addition to their importance for wheat improvement, these results highlight the primary role of pectin despite its low content in the wheat cell wall...
  80. doi Fungal diversity in activated sludge from membrane bioreactors in Berlin
    Mohamed F Awad
    Technische Universitat, Chair of Chemical and Process Engineering, Straße des 17 Juni 135, 10623 Berlin, Germany
    Can J Microbiol 57:693-8. 2011
    ..1%, yeasts at 66.6%, and Penicillium species at 61.1% were the most prevalent. The results indicate that activated sludge is a habitat for growth and sporulation of different groups of fungi, both saprophytic and pathogenic...
  81. doi Filamentous fungi from the Atlantic marine sponge Dragmacidon reticulatum
    Michel R Z Passarini
    Divisão de Recursos Microbianos DRM, CPQBA, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Arch Microbiol 195:99-111. 2013
    ..Data derived from the present study highlight the importance of using a polyphasic approach to get an accurate identification in order to structure a reliable culture collection...
  82. ncbi Antimicrobial and anti-inflammatory activities of leaf extract of Valeriana wallichii DC
    Fazli Khuda
    Department of Pharmacy, University of Peshawar, Peshawar, Pakistan
    Pak J Pharm Sci 25:715-9. 2012
    ..Looking to these results it may be concluded that V. wallichii may be a potential source for activity guided isolation of natural products with antimicrobial and anti-inflammatory-like properties...
  83. doi Bactericidal activity identified in 2S Albumin from sesame seeds and in silico studies of structure-function relations
    Simone Maria-Neto
    Centro de Analises Proteomicas e Bioquimicas, Pos Graduacao em Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia, SGAN Quadra, Módulo B, Brasilia, Distrito Federal, Brazil
    Protein J 30:340-50. 2011
    ....
  84. ncbi Hyphal tip growth and nuclear migration
    X Xiang
    Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Curr Opin Microbiol 2:636-40. 1999
    ..Genes involved in nuclear migration continue to be identified, including putative regulators. The role of microtubules and microtubule motor proteins in hyphal tip growth has also been studied...
  85. ncbi Interfacial control of lid opening in Thermomyces lanuginosa lipase
    Y Cajal
    Physical Chemistry Department, School of Pharmacy, University of Barcelona, Avn Joan XXIII s n, 08028 Barcelona, Spain
    Biochemistry 39:413-23. 2000
    ..A model of interaction consistent with these data and the available X-ray structures is proposed. This is a unique system where the composition and physical properties of the lipid interface control the enzyme activity...
  86. ncbi Flavipucine and brunnescin, two antibiotics from cultures of the mycophilic fungus Cladobotryum rubrobrunnescens
    C Wagner
    , Kaiserslautern, Bundesrepublik Deutschland
    Z Naturforsch C 50:358-64. 1995
    ..and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). The other metabolite, brunnescin (1), is a new tetrasubstituted furan derivative which exhibits antibacterial, antifungal and cytotoxic effects...
  87. ncbi A short formal synthesis of squalamine from a microbial metabolite
    W A Kinney
    Magainin Pharmaceuticals Inc, 5110 Campus Drive, Plymouth Meeting, Pennsylvania 19462, USA
    Org Lett 2:2921-2. 2000
    ..Regioselective C-22 oxidation and C-24 sulfation of the corresponding alcohols in the presence of a free C-7 alcohol make for an efficient preparation of squalamine intermediate 11...
  88. pmc Invasive fungal sinusitis and meningitis due to Arthrographis kalrae in a patient with AIDS
    P V Chin-Hong
    Department of Medicine, University of California, San Francisco, and the Medical Service, San Francisco General Hospital, San Antonio, Texas, USA
    J Clin Microbiol 39:804-7. 2001
    ..There was also an associated fungal meningitis and vasculitis with fungal thrombosis and multiple recent infarcts that involved the frontal lobes, right caudate nucleus, and putamen. Post mortem cultures were positive for A. kalrae...
  89. ncbi [The effect of hydrogen peroxide on the growth of microscopic mycelial fungi isolated from habitats with different levels of radioactive contamination]
    A E Ivanova
    Mikrobiologiia 74:756-65. 2005
    ..The most resistant to hydrogen peroxide was found to be the strain A. alternata 56, isolated from the exclusion zone of the Chernobyl Nuclear Power Plant...
  90. ncbi [Micromycetes and actinobacteria under conditions of many years of natural cryopreservation]
    G A Kochkina
    Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr Nauki 5, Pushchino, Moscow Oblast, 142290 Russia
    Mikrobiologiia 70:412-20. 2001
    ..to more than 20 genera of the divisions Basidiomycota, Ascomycota, and Zygomycota, and some represented mitosporic fungi. Thawing the samples at 35 and 52 degrees C allowed the number of detected fungal genera to be increased by ..
  91. ncbi A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans
    N Pujol
    Laboratoire de Genetique et Physiologie du Developpement, Institut National de la Santé et de la Recherche Médicale Centre National pour la Recherche Scientifique Université de la Mediterranée, 13288, Marseille, France
    Curr Biol 11:809-21. 2001
    ..C. elegans possesses structural homologs of components of this pathway, and this observation raises the possibility that a Toll pathway might also function in nematodes to trigger defense mechanisms or to control development...
  92. ncbi Effects of temperature and relative humidity on sporulation of Metarhizium anisopliae var. acridum in mycosed cadavers of Schistocerca gregaria
    S Arthurs
    Leverhulme Unit for Population Biology and Biological Control, NERC Centre for Population Biology and CABI Bioscience, Imperial College, Silwood Park, Ascot, Berkshire, SL5 7PY, United Kingdom
    J Invertebr Pathol 78:59-65. 2001
    ..The duration of daily exposure to high humidity appears to be a crucial constraint to the recycling ability of M. anisopliae var. acridum...
  93. ncbi [Bacteriological evaluation in chronic otitis media]
    Anna Pajor
    Katedra Otolaryngologii UM w Lodzi, Uniwersytecki Szpital Kliniczny nr 1 im N Barlickiego
    Otolaryngol Pol 60:757-63. 2006
    ..The aim of the study was to investigate the incidence and profile of the aerobic bacterial flora in chronic otitis media and to determine the drug susceptibility of selected isolated bacteria...
  94. ncbi The symbiosis of Bacillus subtilis L-forms with Chinese cabbage seedlings inhibits conidial germination of Botrytis cinerea
    R Walker
    Department of Agriculture and Forestry, University of Aberdeen, 581 King Street, Aberdeen, AB24 5UA, UK
    Lett Appl Microbiol 34:42-5. 2002
    ..To establish whether germination of Botrytis cinerea was affected by the symbiosis of Bacillus subtilis L-form bacteria with Chinese cabbage...
  95. ncbi Comparison of Fonsecaea pedrosoi sclerotic cells obtained in vivo and in vitro: ultrastructure and antigenicity
    Jorge P da Silva
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, CCS, RJ 21949 970, Brazil
    FEMS Immunol Med Microbiol 33:63-9. 2002
    ..pedrosoi. Due to the similarity of the sclerotic cells obtained in vivo and in vitro, the latter can be more adequately in studies of host-parasite interactions in chromoblastomycosis...
  96. ncbi Pathogenicity of Aschersonia spp. against whiteflies Bemisia argentifolii and Trialeurodes vaporariorum
    Ellis T M Meekes
    Applied Plant Research, Division Glasshouse Horticulture, Linnaeuslaan 2A, 1431 JV, Aalsmeer, The Netherlands
    J Invertebr Pathol 81:1-11. 2002
    ..aleyrodis from Colombia, and A. placenta from India showed high spore production on semi-artificial medium and high infection levels of both whitefly species...
  97. ncbi [Drug resistance in the treatment of invasive fungal infections]
    Ingvild Nordøy
    Mikrobiologisk institutt Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 128:2607-11. 2008
    ..The incidence of invasive fungal infections is increasing in parallel with an increase of patients with immunodeficiencies. Resistance to these drugs is becoming a problem in spite of increased and improved treatment options...
  98. ncbi Evaluation of the fungus Beauveria bassiana as a potential biological control agent against phlebotomine sand flies in Colombian coffee plantations
    R Reithinger
    London School of Hygiene and Tropical Medicine, United Kingdom
    J Invertebr Pathol 70:131-5. 1997
    ..In addition, laboratory bioassays where flies were exposed to the fungus applied onto coffee plants (though not filter paper) showed lower mean survival times than the control...
  99. doi Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20
    Porntep Chomcheon
    Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand
    Phytochemistry 70:121-7. 2009
    ..Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed...
  100. pmc Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview
    Carlos P Taborda
    Institute of Biomedical Sciences, Department of Microbiology, University of Sao Paulo, Ave Prof Lineu Prestes, 1374, 2 andar, Sao Paulo, SP 05508 900, Brazil
    Mycopathologia 165:331-9. 2008
    ..Melanization appears to contribute to virulence by reducing the susceptibility of melanized fungi to host defense mechanisms and antifungal drugs...
  101. ncbi [Biological contamination by micromycetes in dried Boletus edulis: research of aflatoxin B1, B2 G1, G2 and ochratoxin A]
    C Lorini
    Dipartimento di Sanita Pubblica, Universita degli Studi di Firenze
    Ann Ig 20:553-62. 2008
    ..The survey confirm that, if the cold chain is kept throughout the process and the distribution, Boletus edulis and analogue mycetes are not a favourable substratum for the growth and the development of moulds...

Research Grants95

  1. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    Amos B Smith; Fiscal Year: 2010
    ..Our experience with discodermolide gives us great confidence in this area. ..
  2. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2007
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  3. Functions of Cryptococcus neoformans mating type loci
    Joseph Heitman; Fiscal Year: 2006
    ..These studies will provide insights into the role of MAT loci and sexual cycles in fungal differentiation and virulence. ..
  4. DEMOLITION AND ASTHMA IN CHICAGO PUBLIC HOUSING
    Samuel Dorevitch; Fiscal Year: 2006
    ....
  5. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  6. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2003
    ..We believe that this philosophy of "unified" synthetic strategies" will be amply demonstrated in this proposal. ..
  7. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2007
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  8. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  9. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2011
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  10. In vivo Regulation of Cytoplasmic Dynein
    Xin Xiang; Fiscal Year: 2009
    ..Our third aim is to create null-mutants of several proteins in the dynein complex to study their functions in dynein regulation, and identify novel dynein regulators by cloning additional nud genes. ..
  11. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2010
    ..The goal is to harness signaling cascades to develop novel antifungal therapies. ..
  12. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 2009
    ..Our experience with discodermolide gives us great confidence in this area. ..
  13. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....
  14. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...
  15. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 1991
    ..FK506 is therefore an important target for total synthesis, not only for its intrinsic synthetic challenge, but also due to its extrinsic worth to the field of medicine...
  16. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 1993
    ..We believe that this philosophy of "unified synthetic strategies" will be further developed by this proposal...
  17. SYNTHESIS OF CYCLOPENTENOID ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1980
    ..Once such features are identified the design of new and possibly more effective antitumor drugs should be feasible...
  18. IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 1999
    ..The Investigator s goals are to identify immunophilins, calcineurin, and their functions in C. neoformans to delineate a signal transduction pathway regulating pathogenesis and to define novel antifungal drug targets. ..
  19. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  20. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2010
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  21. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  22. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  23. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  24. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2009
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  25. NOVEL ANTIFUNGAL DRUG TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 2005
    ..Our long term goal is to identify unique targets and develop novel antifungal drug therapies. ..
  26. ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITING
    Joseph Heitman; Fiscal Year: 2005
    ....
  27. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2007
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  28. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2007
    ....
  29. Genetics Training Grant-Year 26
    Joseph Heitman; Fiscal Year: 2007
    ..Here we seek to expand the NIH supported portion of the training program to a total of eight new students per year. ..
  30. ROLE OF CALCINEURIN IN CRYPTOCOCCUS NEOFORMANS VIRULENCE
    Joseph Heitman; Fiscal Year: 2002
    ..Maria Cardenas; biochemical and protein purification support and Dr. John Perfect; transformation of C. neoformans and virulence analysis) combine for a highly enthusiastic rating of this application. ..