mitosporic fungi

Summary

Summary: A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.

Top Publications

  1. ncbi Antibacterial and antifungal activity of Senecio inaequidens DC. and Senecio vulgaris L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 18:777-9. 2004
  2. ncbi Fungal pathogen reduces potential for malaria transmission
    Simon Blanford
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT Scotland, UK
    Science 308:1638-41. 2005
  3. ncbi Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil
    A K Gupta
    Division of Dermatology, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 40:529-34. 2002
  4. ncbi Virulence of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes) on Anastrepha ludens (Diptera: Tephritidae): laboratory and field trials
    R Lezama-Gutierrez
    Facultad de Ciencias Biológicas y Agropecuarias de la Universidad de Colima, Tecomán, Mexico
    J Econ Entomol 93:1080-4. 2000
  5. ncbi Antifungal activity of the stem bark of Ailanthus excelsa
    B C Joshi
    Chemistry Department, Lucknow University, Lucknow, India
    Fitoterapia 74:689-91. 2003
  6. ncbi Antibacterial activity of Galeola foliata
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:494-6. 2004
  7. ncbi Antimicrobial synergism and antagonism of salicylaldehyde in Filipendula vulgaris essential oil
    N Radulovic
    Department of Chemistry, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Fitoterapia 78:565-70. 2007
  8. ncbi Antimicrobial activities of Indian Berberis species
    Meenakshi Singh
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226001, India
    Fitoterapia 78:574-6. 2007
  9. ncbi Antifungal properties of Pseudarthria viscida
    M A Deepa
    Department of Botany, Bharathiar University, Coimbatore, Tamilnadu 46, India
    Fitoterapia 75:581-4. 2004
  10. ncbi Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa
    Eui Il Hwang
    KT and G Central Research Institute, Daejeon, Korea
    Planta Med 73:679-82. 2007

Research Grants

  1. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    Amos B Smith; Fiscal Year: 2010
  2. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2007
  3. Functions of Cryptococcus neoformans mating type loci
    Joseph Heitman; Fiscal Year: 2006
  4. DEMOLITION AND ASTHMA IN CHICAGO PUBLIC HOUSING
    Samuel Dorevitch; Fiscal Year: 2006
  5. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
  6. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2003
  7. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2007
  8. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
  9. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2011
  10. In vivo Regulation of Cytoplasmic Dynein
    Xin Xiang; Fiscal Year: 2009

Detail Information

Publications170 found, 100 shown here

  1. ncbi Antibacterial and antifungal activity of Senecio inaequidens DC. and Senecio vulgaris L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 18:777-9. 2004
    ..and Senecio vulgaris L. were assayed. The hexane extract of Senecio vulgaris L. (MIC 0.031 mg/ml) showed significant activity against Trichophyton tonsurans...
  2. ncbi Fungal pathogen reduces potential for malaria transmission
    Simon Blanford
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT Scotland, UK
    Science 308:1638-41. 2005
    ..Residual sprays of fungal biopesticides might replace or supplement chemical insecticides for malaria control, particularly in areas of high insecticide resistance...
  3. ncbi Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil
    A K Gupta
    Division of Dermatology, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 40:529-34. 2002
    ..Some success with alternative week therapy was also noted in one patient. The favorable response and lack of significant adverse effects suggests that these regimens may be an option for some patients with chromoblastomycosis...
  4. ncbi Virulence of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes) on Anastrepha ludens (Diptera: Tephritidae): laboratory and field trials
    R Lezama-Gutierrez
    Facultad de Ciencias Biológicas y Agropecuarias de la Universidad de Colima, Tecomán, Mexico
    J Econ Entomol 93:1080-4. 2000
    ..M. anisopliae may offer a preferable alternative to chemicals as a biological control agent against A. ludens...
  5. ncbi Antifungal activity of the stem bark of Ailanthus excelsa
    B C Joshi
    Chemistry Department, Lucknow University, Lucknow, India
    Fitoterapia 74:689-91. 2003
    ..The chloroform extract showed fungistatic and fungicidal activity against Aspergillus niger, A. fumigatus, Penicillium frequentence, P. notatum and Botrytis cinerea...
  6. ncbi Antibacterial activity of Galeola foliata
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:494-6. 2004
    ..A broad spectrum antibacterial activity (24 bacteria and protozoan) was exhibited by both parts. A very good level of activity was demonstrated by the CH2Cl2 and EtOAc fractions. None of the fractions were active against the moulds...
  7. ncbi Antimicrobial synergism and antagonism of salicylaldehyde in Filipendula vulgaris essential oil
    N Radulovic
    Department of Chemistry, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Fitoterapia 78:565-70. 2007
    ..The maximum (negative) interaction was shown to correspond approximately to the mixture at the 40:60 (methyl salicylate/salicylaldehyde) mol ratio resulting in the complete loss of activity at the investigated dose...
  8. ncbi Antimicrobial activities of Indian Berberis species
    Meenakshi Singh
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226001, India
    Fitoterapia 78:574-6. 2007
    ..B. aristata root extract gave low MICs values against Bacillus cereus, Escherichia coli, Staphylococcus aureus and Aspergillus flavus while stem extract against B. cereus and Streptococcus pneumoniae...
  9. ncbi Antifungal properties of Pseudarthria viscida
    M A Deepa
    Department of Botany, Bharathiar University, Coimbatore, Tamilnadu 46, India
    Fitoterapia 75:581-4. 2004
    ..The extracts of leaf, root, stem, and the callus obtained from Pseudarthria viscida showed significant inhibitory activity against some fungal pathogens causing major diseases in crop plants and stored food grains...
  10. ncbi Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa
    Eui Il Hwang
    KT and G Central Research Institute, Daejeon, Korea
    Planta Med 73:679-82. 2007
    ..The results indicate that these compounds are specific inhibitors of chitin synthase 2 and can potentially serve as antifungal agents...
  11. ncbi Antimicrobial activity of four species of Berberidaceae
    Ai Rong Li
    School of Life Science, Nanjing University, Nanjing, China
    Fitoterapia 78:379-81. 2007
    ..Most of the extracts have been proved to be active against Gram(+) bacteria...
  12. ncbi Antibacterial and antifungal activities of Quassia undulata and Quassia amara extracts in vitro
    E O Ajaiyeoba
    Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 32:353-6. 2003
    ..0-29.0 mm for the tested extracts/drugs. All the extracts have shown impressive activities against the commonly encountered microorganisms and have thus confirmed the folklore uses of the plants in the African ethnomedicine...
  13. ncbi Antifungal activity of Zuccagnia punctata Cav.: evidence for the mechanism of action
    Laura Svetaz
    Farmacognosia, Facultad Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina
    Planta Med 73:1074-80. 2007
    ....
  14. ncbi Two new benzofuranes from Eupatorium aschenbornianum and their antimicrobial activity
    Maria Yolanda Rios
    Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
    Planta Med 69:967-70. 2003
    ..5 microg/mL ( T. mentagrophytes), 12.5 microg/mL ( T. rubrum), 100 microg/mL ( C. albicans) and 200 microg/mL ( A. niger)]...
  15. ncbi Antifungal activity of wogonin
    Mahesh Pal
    Department of Phytochemistry, National Botanical Research Institute, Lucknow 226001, India
    Phytother Res 17:1215-6. 2003
    ..notatum and Botrytis cinerea, in a concentration dependent fashion, when tested by turbidity and spore germination methods. The effects produced by the compound were compared with the standard antifungal agent griseofulvin...
  16. ncbi Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia
    C Wiart
    Department of Pharmacy, University of Malaya, Malaysia
    Fitoterapia 75:68-73. 2004
    ....
  17. ncbi Suppression of phytopathogenic fungi by hexane extract of Nepenthes ventricosa x maxima leaf
    Kwang Soo Shin
    Department of Microbiology, Daejeon University, Daejeon 300 716, Republic of Korea
    Fitoterapia 78:585-6. 2007
    ..stolonifer and Sclerotinia sclerotiorum...
  18. ncbi Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea
    P K Chaudhuri
    Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India
    Phytother Res 18:114-7. 2004
    ..The structures of the compounds were established by spectral and chemical studies...
  19. ncbi Phyllanthus piscatorum, ethnopharmacological studies on a women's medicinal plant of the Yanomamï Amerindians
    Jürg Gertsch
    Swiss Federal Institute of Technology Zurich, Institute of Pharmaceutical Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Ethnopharmacol 91:181-8. 2004
    ....
  20. ncbi Antimicrobial activity of Memecylon malabaricum leaves
    Kiran Kumar Hullatti
    Department of Applied Botany and Biotechnology, University of Mysore, Manasagangotri, Mysore 570 006, India
    Fitoterapia 75:409-11. 2004
    ..The petroleum ether, chloroform and methanol extracts of Memecylon malabaricum leaves were tested for antimicrobial activity. Only methanol extract has shown activity against bacteria both Gram (+) and Gram (-), and fungi...
  21. ncbi Antibacterial and antifungal activities of Euroschinus papuanus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:412-6. 2004
    ..Excellent activity was demonstrated by the E fractions of stem heart wood, D of root bark, and E of root heart wood. Antifungal activity was exhibited by the B fractions of leaves, stem heartwood and root bark...
  22. ncbi In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)
    J P Dzoyem
    Laboratory of Mycology, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon
    Phytother Res 21:671-4. 2007
    ..Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent...
  23. ncbi Antifungal activity of Aloe vera leaves
    Oana Rosca-Casian
    Department of Biology, Faculty of Biology and Geology, Babes Bolyai University, 42 Republicii Street, 400015 Cluj Napoca, Romania
    Fitoterapia 78:219-22. 2007
    ..sp. gladioli, Heterosporium pruneti and Penicillium gladioli on Czapek-agar medium. The minimum fungicidal concentration (MFC) varied between 80 and 100 microl/ml, depending on the fungal species...
  24. ncbi A novel bioactive flavonol glycoside from Teramnus labialis spreng
    R N Yadava
    Department of Chemistry, Natural Products Laboratory, Dr H S Gour University, Sagar M P 470003, India
    Nat Prod Res 18:537-42. 2004
    ..The chloroform extract of compound (1) showed antibacterial and antifungal activities...
  25. ncbi Biological activity of Spatoglossum asperum: a brown alga
    Jehan Ara
    Department of Food Science and Technology, University of Karachi, Karachi-75270, Pakistan
    Phytother Res 19:618-23. 2005
    ..Oily fractions of S. asperum also showed hypolipidaemic activity in normal, triton-induced and high fat diet-induced hyperlipidaemic rats without producing any ill effect on cardiac and liver enzymes...
  26. ncbi Antimicrobial activity of Pycnogenol
    Maria Angeles Calvo Torras
    Veterinary Faculty, University Autonomous of Barcelona, Spain
    Phytother Res 19:647-8. 2005
    ..025% could counteract the growth of all the strains investigated in our study. These results conform with clinical oral health care studies describing the prevention of plaque formation and the clearance of candidiasis by Pycnogenol...
  27. ncbi Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill
    N F A Bafi-Yeboa
    Department of Biology, University of Ottawa, Ottawa, Ont, Canada K1N 6N5
    Phytomedicine 12:370-7. 2005
    ..902, p<0.001). The results provide a phytochemical basis for the very widespread use of Z. americanum in indigenous North American ethnomedical tradition for conditions that may be related to fungal infections...
  28. ncbi Antifungal activities of six South African Terminalia species (Combretaceae)
    P Masoko
    Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa
    J Ethnopharmacol 99:301-8. 2005
    ..0.08 mg/ml, some were with MIC values as low as 0.02 mg/ml. Microsporum canis was the most susceptible microorganism and Terminalia sericea extracts were the most active against nearly all microorganisms tested...
  29. ncbi Antifungal properties of surangin B, a coumarin from Mammea longifolia
    Yanshen Deng
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Planta Med 71:364-5. 2005
    ..3 microM) and Botrytis cinerea (IC50 = 1.4 microM), although Alternaria dauci was considerably more tolerant of this coumarin (IC50 = 500 microM). Our results indicate that surangin B may have potential as an antifungal agent...
  30. ncbi Antifungal activity of steroidal glycosides from Yucca gloriosa L
    A Favel
    Laboratory of Botany and Cryptogamy, Faculty of Pharmacy, Marseille, France
    Phytother Res 19:158-61. 2005
    ..78 and 12.5 microg[sol ]mL. The most sensitive filamentous species was A. fumigatus (MIC = 1.56 microg[sol ]mL). For most of the strains, the MICs of both glycosides were similar to those of the reference antifungal agent...
  31. ncbi Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark
    Renato Bruni
    Dipartimento di Biologia Evolutiva e Funzionale, Parco Area delle Scienze 11, 43100 Parma, Italy
    Fitoterapia 77:538-45. 2006
    ..The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum...
  32. ncbi Antifungal activities of five Combretaceae used in Togolese traditional medicine
    K Batawila
    Laboratory of Botany and Plant Ecology, Research and Education Centre for Medicinal Plants, University of Lome, P O Box 1515, Lome, Togo
    Fitoterapia 76:264-8. 2005
    ..25 mg/ml to 4 mg/ml. The results confirm the traditional therapeutic properties of these plants...
  33. ncbi Antimicrobial activity of some Indian mosses
    Meenakshi Singh
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226001, India
    Fitoterapia 78:156-8. 2007
    ..Sphagnum junghuhnianum, Barbula javanica, Barbula arcuata, Brachythecium populeum, Brachythecium rutabulum, Mnium marginatum and Entodon cf rubicundus were found to be most active against all the organisms...
  34. ncbi Antifungal activity of Rubia tinctorum, Rhamnus frangula and Caloplaca cerina
    N T Manojlovic
    Faculty of Science, University of Kragujevac, P O Box 60, 34000 Kragujevac, Serbia and Montenegro
    Fitoterapia 76:244-6. 2005
    ....
  35. ncbi A novel pentacyclic triterpene from Leontodon filii
    Zélia Tostão
    Departamento de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal
    Fitoterapia 76:173-80. 2005
    ..The fungicidal efficacy of the chloroform and methanol extracts of the plant was also evaluated, a protective effect being found against Plasmopara viticola, Botrytis cinerea, particularly powerful against Pyricularia oryzae...
  36. ncbi Chemical composition and antimicrobial activity of Chamaecyparis obtusa leaf essential oil
    Jae Kyung Yang
    Faculty of Forest Science and Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 660 701, Republic of Korea
    Fitoterapia 78:149-52. 2007
    ..alpha-Terpinyl acetate, sabinene, isobornyl acetate and limonene were found to be the major components. The oil showed relatively strong antibacterial activities against Gram (+) bacteria and some fungi...
  37. ncbi Color versus bioactivity in the flowers of Bougainvillea spectabilis (Nyctaginaceae)
    Muhammad Shaiq Ali
    H E J Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:1-5. 2005
    ..The extract of white flowers also exhibits toxicity against shrimp larvae with a LD50 value of 33.5627 microg/mL. However, none of the tested samples gave positive responses against any tested fungi...
  38. ncbi Antimicrobial activity of Chenopodium botrys essential oil
    Zoran A Maksimović
    Institute of Pharmacognosy, School of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia and Montenegro
    Fitoterapia 76:112-4. 2005
    ..Essential oil, isolated by hydrodistillation from Chenopodium botrys aerial parts, expressed significant bactericidal and fungicidal activity against selected strains of microorganisms...
  39. ncbi Antifungal activity of Cynara scolymus L. extracts
    X F Zhu
    Research Center for Eco-Environmental Sciences and Graduate School, Chinese Academy of Sciences, Beijing 100085, China
    Fitoterapia 76:108-11. 2005
    ..leaves, heads and stems were tested for their antifungal activity using the agar-well diffusion assay technique. The leaves extracts and the ethanol fractions were found to be the most effective extract against all the tested organisms...
  40. ncbi Antimicrobial and cytotoxic activities of Achyranthes ferruginea
    M Mukhlesur Rahman
    Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
    Fitoterapia 78:260-2. 2007
    ..Both crude extract (CE) and compound 1 showed significant cytotoxicity of LC(50) at 16.21 microg/ml and 11.70 microg/ml, respectively...
  41. ncbi Studies on the bioactivity and elementology of marine algae from the coast of Karachi, Pakistan
    Muhammad Afzal Rizvi
    Hamdard Institute of Advanced Studies and Research, Hamdard University, Karachi, Pakistan
    Phytother Res 18:865-72. 2004
    ..Among them Ca, Cr and Pb were found to occur in largest amount in green seaweeds, Co, Cu, Fe and Zn in greatest quantity in brown seaweeds, while Cd, K, Mg and Na in highest proportion in the investigated red seaweeds...
  42. ncbi New and bioactive aromatic compounds from Zanthoxylum zanthoxyloides
    Emerson F Queiroz
    Laboratoire de Pharmacognosie et Phytochimie, , , , Switzerland
    Planta Med 72:746-50. 2006
    ..The structures of the isolated compounds were elucidated by classical spectroscopic methods including UV, NMR, MS and HR-MS...
  43. ncbi Antimicrobial and antioxidant activities of three Mentha species essential oils
    Neda Mimica-Dukic
    University of Novi Sad, Faculty of Natural Sciences and Mathematics, Department of Chemistry, Novi Sad, FR Yugoslavia
    Planta Med 69:413-9. 2003
    ..longifolia and M. piperita and 1,8-cineole in the oil of M. aquatica...
  44. ncbi Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth
    B Singh
    Department of Botany, University of Rajasthan, Jaipur, India
    Phytother Res 17:814-6. 2003
    ..39) against E. coli and hexacosanoic acid had greater activity against A. flavus (IZ = 11.56). The present study deals with antimicrobial screening of sequential extracts and isolated terpenoids...
  45. ncbi Antimicrobial activity of Toona ciliata and Amoora rohituka
    Rasheduzzaman Chowdhury
    Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
    Fitoterapia 74:155-8. 2003
    ..ciliata, exhibited significant in vitro antibacterial activity. The extracts also demonstrated mild antifungal effect...
  46. ncbi Antibacterial activity of Artocarpus heterophyllus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, PMB, Lae, Papua New Guinea
    Fitoterapia 74:501-5. 2003
    ..The butanol fractions of the root bark and fruits were found to be the most active. None of the fractions were active against the fungi tested...
  47. ncbi Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum
    K Morteza-Semnani
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Fitoterapia 74:493-6. 2003
    ..Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant...
  48. ncbi Zaluzanin D: a fungistatic sesquiterpene from Vernonia arborea
    G N Krishna Kumari
    Centre for Natural Products, SPIC Science Foundation, SPIC House, 88 Mount Road, Chennai 600 032, India
    Fitoterapia 74:479-82. 2003
    ..Zaluzanin D, a sesquiterpene lactone has been isolated from the aerial parts of Vernonia arborea as a major constituent (0.04%). Antifungal activity of zaluzanin D has been studied against six plant-pathogenic fungi...
  49. ncbi Antifungal compounds from Zanthoxylum chiloperone var. angustifolium
    Céline Thouvenel
    Laboratoire de Pharmacognosie UPRES A 8076 CNRS BIOCIS, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    Phytother Res 17:678-80. 2003
    ..interdigitale with MICs values between 5.3 and 46 micro mol/L. 5-methoxy-canthin-6-one was active against only Trichophyton mentagrophytes var. interdigitale with a MIC value of 12.3 micro mol/L...
  50. ncbi New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth
    Hong-Wei Liu
    Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Wenhua-Road 103, Shenyang 110016, China
    J Asian Nat Prod Res 5:241-7. 2003
    ..Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro...
  51. ncbi Antibacterial and antifungal activity of Erigeron breviscapus
    H Liu
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Fitoterapia 74:387-9. 2003
    ..The antibacterial and antifungal properties of the ethanol extract of Erigeron breviscapus whole plant was evaluated. The extract showed a moderate antibacterial activity and a high antifungal activity...
  52. ncbi Antifungal activity of some Cuban Zanthoxylum species
    R Diéguez-Hurtado
    Centro de Química Farmacéutica, Calle 200 y 21, Atabey, Playa, Ciudad de La Habana, Cuba
    Fitoterapia 74:384-6. 2003
    ..Ethanolic extracts of the trunk bark of Zanthoxylum fagara, Z. elephantiasis and Z. martinicense showed activity against different species of fungi. No antibacterial activity was detected...
  53. ncbi Antimicrobial activity of Ximenia americana
    M E F A Omer
    Medicinal and Aromatic Plants Research Institute, National Centre for Research, PO Box 2404, Khartoum, Sudan
    Fitoterapia 74:122-6. 2003
    ..Extracts of the bark, leaves, root and stem of Ximenia americana were tested for their antimicrobial and antifungal activity...
  54. ncbi Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids
    Anna Vollekova
    Mycological Laboratory, Department of Dermatovenerology, Slovak Postgraduate Academy of Medicine, Bratislava, Slovakia
    Phytother Res 17:834-7. 2003
    ..5 to >100 micro g/mL. Our results suggest that jatrorrhizine may serve as a leading compound for further studies to develop new antifungal agents with highly potent antifungal activity and low host toxicity...
  55. ncbi Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens
    A Vonshak
    Ben-Gurion University of the Negev, Jacob Blaustein Institute for Desert Research, Albert Katz Department of Dryland Biotechnologies, Desert Plant Biotechnology Laboratory, Sede Boqer Campus, 84990, Israel
    Phytother Res 17:1123-5. 2003
    ..chebula. Chebulinic acid, a known tannin of T. chebula was tested and found not inhibitory, thus a search for the active compound is needed...
  56. ncbi Bioassay-guided isolation and identification of antifungal compounds from ginger
    C Ficker
    Ottawa-Carleton Institutes of Biology and Chemistry, Carleton University and University of Ottawa, Ottawa ON, Canada
    Phytother Res 17:897-902. 2003
    ..Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy...
  57. ncbi Antibacterial activity of Pterocarpus indicus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, PMB, Lae, Papua New Guinea
    Fitoterapia 74:603-5. 2003
    ..All the fractions exhibited a wide spectrum of antibacterial activity. The activity was more pronounced in the butanol and methanol fractions. None were active against the moulds...
  58. ncbi Composition and antimicrobial activity of Achillea clavennae L. essential oil
    Nada Bezić
    University of Split, Faculty of Natural Science, Mathematics and Education, Department of Biology, Teslina 12, 21000 Split, Croatia
    Phytother Res 17:1037-40. 2003
    ..A. clavennae oil was found to possess antimicrobial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa and all fungal organisms...
  59. ncbi Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana
    V L Niranjan Reddy
    Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Fitoterapia 74:600-2. 2003
    ..Compound 1 showed activity against this fungus...
  60. ncbi Antimicrobial activity of some Hypericum species
    A Ferraz
    , UFRGS, Porto Alegre, RS, Brazil
    Phytomedicine 10:511-6. 2003
    ..perforatum, which has high concentrations of rutin, these species do not produce this flavonoid or it appears as traces. The tannin concentration varied between 5.1 and 16.7% in H. myrianthum and H. ternum, respectively...
  61. ncbi Antibacterial and antifungal activity of Indonesian ethnomedical plants
    E Goun
    Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA
    Fitoterapia 74:592-6. 2003
    ..Tylophora asthmatica and Hyptis brevipes demonstrated high activity in this bioassay system. These findings should stimulate the search for novel, natural product such as new antibacterial and antifungal agents...
  62. ncbi Pharmacological and toxicological activity of Heterophyllaea pustulata anthraquinone extracts
    S C Núñez Montoya
    Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Quimicas, UNC, Instituto Multidisciplinario de Biología Vegetal IMBiV CONICET, Cordoba, Argentina
    Phytomedicine 10:569-74. 2003
    ..Acute toxicity studies revealed a low toxicity in mice for the anthraquinonic extracts, as measured in the LD50 value (123 mg/kg body wt. i.v.), and death was not observed at doses of up to 4000 mg/kg body wt. s.c...
  63. ncbi Filamentous fungi associated with holothurians from the sea of Japan, off the primorye coast of Russia
    M V Pivkin
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia
    Biol Bull 198:101-9. 2000
    ..Twenty-seven species of marine fungi, mostly facultative ones belonging to the mitosporic fungi, were isolated from the holothurians and identified...
  64. ncbi Concentration and species diversity of airborne fungi near busy streets in Lithuanian urban areas
    Albinas Lugauskas
    Institute of Botany, Laboratory of Biodeterioration Research, Zaliuju ezeru 49, LT 2021 Vilnius, Lithuania
    Ann Agric Environ Med 10:233-9. 2003
    ..b>Mitosporic fungi comprised 138 genera, 358 species, and comprised the vast majority of identified species: 358 out of 430 (83...
  65. ncbi Stromata, sporangiomata and chlamydosori of Phytophthora ramorum on inoculated Mediterranean woody plants
    Eduardo Moralejo
    Institut Mediterrani d Estudis Avançats, IMEDEA CSIC UIB Miquel Marquès 21, 07190 Esporles, Balearic Islands, Spain
    Mycol Res 110:1323-32. 2006
    ..Sporangiomata bore short sporangiophores and clusters of 20-100 sporangia and resembled sporodochia of the mitosporic fungi. The biological significance of these multihyphal structures is discussed...
  66. ncbi L-arginine is essential for conidiation in the filamentous fungus Coniothyrium minitans
    Xiaoyan Gong
    The Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China
    Fungal Genet Biol 44:1368-79. 2007
    Conidiation is important in the life cycles of mitosporic fungi for survival and transmission...
  67. ncbi Cyclic GMP as a second messenger in the nitric oxide-mediated conidiation of the mycoparasite Coniothyrium minitans
    Bo Li
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei Province, People s Republic of China
    Appl Environ Microbiol 76:2830-6. 2010
    Understanding signaling pathways that modulate conidiation of mitosporic fungi is of both practical and theoretical importance...
  68. ncbi Pine nuts: the mycobiota and potential mycotoxins
    M Weidenbörner
    Institut fur Angewandte Mikrobiologie, Heinrich Buff Ring, Giessen, Germany
    Can J Microbiol 47:460-3. 2001
    ..In total, 1832 fungi belonging to 31 species and 15 genera (Ascomycota, 2; Zygomycota, 3; mitosporic fungi, 10) could be isolated. Cladosporium spp...
  69. ncbi Biotransformation of the polycyclic musks HHCB and AHTN and metabolite formation by fungi occurring in freshwater environments
    Claudia Martin
    UFZ, Department of Environmental Microbiology, Leipzig, Germany
    Environ Sci Technol 41:5395-402. 2007
    ..strain UHH 1-13-18-4 and Clavariopsis aquatica, two mitosporic fungi derived from freshwater environments...
  70. ncbi Isolation and characterisation of polychlorinated biphenyl (PCB) degrading fungi from a historically contaminated soil
    Valeria Tigini
    Department of Plant Biology, University of Turin, Viale Mattioli 25, 10125 Turin, Italy
    Microb Cell Fact 8:5. 2009
    ..abstract:..
  71. ncbi A comparative account of backwater and brackish water marine mycoflora of North Malabar (Kerala) India
    Gayatri R Nambiar
    Department of P G Studies and Research in Botany, Sir Syed College, Taliparamba, Kerala, India
    C R Biol 331:294-7. 2008
    ..A total of 30 marine fungi were isolated, which include 19 Ascomycetes, 1 Basidiomycete, and 10 Mitosporic fungi. Periconia prolifica emerged as the most dominant one in terms of percent frequency of occurrence and percent ..
  72. ncbi The biochemistry of oleate induction: transcriptional upregulation and peroxisome proliferation
    Aner Gurvitz
    Medical University of Vienna, Center of Physiology and Pathophysiology, Department of Physiology, Section of Physiology of Fatty Acid Lipid Metabolism, 1090 Vienna, Austria
    Biochim Biophys Acta 1763:1392-402. 2006
    ....
  73. ncbi Long-term storage of bionanodevices by freezing and lyophilization
    Raviraja Seetharam
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Lab Chip 6:1239-42. 2006
    ....
  74. ncbi A dose-dependent relationship between the severity of visible mold growth and IgE levels of pre-school-aged resident children in Taiwan
    N Y Hsu
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Indoor Air 20:392-8. 2010
    ..Evidence as such may derive different priority-setting when designing preventive measures for managing indoor air quality...
  75. ncbi Fungi in freshwaters: ecology, physiology and biochemical potential
    Gerd Joachim Krauss
    Faculty I of Natural Science Biological Science, Institute of Biochemistry and Biotechnology, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    FEMS Microbiol Rev 35:620-51. 2011
    ..The same capabilities occur in freshwater fungi. This suggests a largely ignored role of these organisms in attenuating pollutant loads in freshwaters and their potential use in environmental biotechnology...
  76. ncbi Pediatric Metarrhizium anisopliae keratitis
    W Walker Motley
    Abrahamson Pediatric Eye Institute, Cincinnati Children s Hospital Medical Center, and Department of Ophthalmology, University of Cincinnati, Cincinnati, OH 45229, USA
    J AAPOS 15:101-3. 2011
    ..anisopliae corneal ulcer who was treated effectively with topical natamycin after identification of the organism by corneal culture. Topical amphotericin B was not effective...
  77. ncbi Bactericidal activity identified in 2S Albumin from sesame seeds and in silico studies of structure-function relations
    Simone Maria-Neto
    Centro de Analises Proteomicas e Bioquimicas, Pos Graduacao em Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia, SGAN Quadra, Módulo B, Brasilia, Distrito Federal, Brazil
    Protein J 30:340-50. 2011
    ....
  78. ncbi Susceptibility of the ant-cultivated fungus Leucoagaricus gongylophorus (Agaricales: Basidiomycota) towards microfungi
    A Silva
    Departamento de Produção Vegetal Defesa Fitossanitária, Universidade Estadual Paulista, Botucatu SP, Brazil
    Mycopathologia 162:115-9. 2006
    ....
  79. ncbi Isolation, identification and seasonal distribution of soilborne fungi in tea growing areas of Iyidere-Ikizdere vicinity (Rize-Turkey)
    Sengul Alpay Karaoglu
    Department of Biology, Faculty of Arts and Sciences at Rize, Karadeniz Technical University, Rize, 53100, Turkey
    J Basic Microbiol 46:208-18. 2006
    ..8%, 14.8%, 9.6% and 8.4%, respectively). Penicillium phialosporum, Penicillium trzebinskianum and Gliocladium virens were reported for the first time in Turkey...
  80. ncbi In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis
    Manuel Cuenca-Estrella
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda Madrid, Spain
    Antimicrob Agents Chemother 50:2248-50. 2006
    ..Synergy was observed for some isolates and combinations, particularly with posaconazole-terbinafine (68% of strains), amphotericin B-caspofungin (60%), and posaconazole-caspofungin (48%)...
  81. ncbi Important mycotoxins and the fungi which produce them
    Jens C Frisvad
    Center for Microbial Biotechnology, BioCentrum-DTU, Technical University of Denmark, Lyngby
    Adv Exp Med Biol 571:3-31. 2006
  82. ncbi Fungi and actinomycetes associated with Meloidogyne spp. eggs and females in China and their biocontrol potential
    Man-Hong Sun
    Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China
    J Invertebr Pathol 93:22-8. 2006
    ..They reduced tomato root gall index by 13.4-58.9% compared to the no treatment control...
  83. ncbi Occupational asthma in professional cleaning work: a clinical study
    R Mäkelä
    Occupational Medicine, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Occup Med (Lond) 61:121-6. 2011
    ..Several epidemiological studies have reported an increased risk of asthma among professional cleaners. To date, however, no analysis of large patient series from clinic of occupational medicine has been published...
  84. ncbi Localised microsphaeropsis arundinis infection of the subcutis of a cat
    Mark B Krockenberger
    Faculty of Veterinary Science, The University of Sydney, B14, NSW 2006, Australia
    J Feline Med Surg 12:231-6. 2010
    ....
  85. ncbi Isolation of mycoparasitic-related transcripts by SSH during interaction of the mycoparasite Stachybotrys elegans with its host Rhizoctonia solani
    Danielle C Morissette
    Department of Plant Science, McGill University, Quebec, Canada H9X 3V9
    Curr Genet 53:67-80. 2008
    ..elegans genome. The results present the useful application of EST analysis on S. elegans and provide preliminary indication of gene expression putatively involved in mycoparasitism...
  86. ncbi Humicola insolens cutinase-catalyzed lactone ring-opening polymerizations: kinetic and mechanistic studies
    Mo Hunsen
    Department of Chemistry, Kenyon College, Gambier, Ohio 43022, USA
    Biomacromolecules 9:518-22. 2008
    ..In addition, the relative activities of immobilized Candida antarctica lipase B (CALB) and HIC for epsilon-CL and PDL polymerizations are reported herein...
  87. ncbi Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3-arylacrylonitriles as antifungal and anticancer agents
    Jairo Quiroga
    Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Quimica, Universidad del Valle, Cali, Colombia
    Arch Pharm (Weinheim) 340:603-6. 2007
    ....
  88. ncbi Growth, keratinolytic proteinase activity and thermotolerance of dermatophytes associated with alopecia in Uyo, Nigeria
    J P Essien
    Department of Microbiology, University of Uyo, P M B 1017, Uyo, Nigeria
    Acta Microbiol Immunol Hung 56:61-9. 2009
    ..This plus the high thermostability of the enzymes are important attributes in the consideration of preventive and therapeutic methods against dermatophytes in the tropics...
  89. ncbi Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview
    Carlos P Taborda
    Institute of Biomedical Sciences, Department of Microbiology, University of Sao Paulo, Ave Prof Lineu Prestes, 1374, 2 andar, Sao Paulo, SP 05508 900, Brazil
    Mycopathologia 165:331-9. 2008
    ..Melanization appears to contribute to virulence by reducing the susceptibility of melanized fungi to host defense mechanisms and antifungal drugs...
  90. ncbi [Drug resistance in the treatment of invasive fungal infections]
    Ingvild Nordøy
    Mikrobiologisk institutt Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 128:2607-11. 2008
    ..The incidence of invasive fungal infections is increasing in parallel with an increase of patients with immunodeficiencies. Resistance to these drugs is becoming a problem in spite of increased and improved treatment options...
  91. ncbi Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20
    Porntep Chomcheon
    Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand
    Phytochemistry 70:121-7. 2009
    ..Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed...
  92. ncbi [Bacteriological evaluation in chronic otitis media]
    Anna Pajor
    Katedra Otolaryngologii UM w Lodzi, Uniwersytecki Szpital Kliniczny nr 1 im N Barlickiego
    Otolaryngol Pol 60:757-63. 2006
    ..The aim of the study was to investigate the incidence and profile of the aerobic bacterial flora in chronic otitis media and to determine the drug susceptibility of selected isolated bacteria...
  93. ncbi [Biological contamination by micromycetes in dried Boletus edulis: research of aflatoxin B1, B2 G1, G2 and ochratoxin A]
    C Lorini
    Dipartimento di Sanita Pubblica, Universita degli Studi di Firenze
    Ann Ig 20:553-62. 2008
    ..The survey confirm that, if the cold chain is kept throughout the process and the distribution, Boletus edulis and analogue mycetes are not a favourable substratum for the growth and the development of moulds...
  94. ncbi The role of indoor allergens in the development of asthma
    Jonathan M Gaffin
    Department of Pediatrics, Boston Children s Hospital, Massachusetts, USA
    Curr Opin Allergy Clin Immunol 9:128-35. 2009
    ..Asthma prevalence has markedly increased over the past 30 years. Although atopy and exposure to environmental allergens are known to exacerbate asthma, recent literature supports a causal role of indoor allergens in disease development...
  95. ncbi Murine models of airway fungal exposure and allergic sensitization
    Steven P Templeton
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Med Mycol 48:217-28. 2010
    ..Future studies will require animal models that accurately reflect natural fungal exposures and identify environmental factors that influence immune development and thus promote respiratory fungal allergy and disease...
  96. ncbi Aquatic hyphomycete communities as potential bioindicators for assessing anthropogenic stress
    M Sole
    Helmholtz Centre for Environmental Research UFZ, Department of Environmental Microbiology, Permoserstrasse 15, D 04318 Leipzig, Germany
    Sci Total Environ 389:557-65. 2008
    ..et Thérry), Tumularia aquatica (Ingold) and Lemonniera aquatica (De Wild) being most sensitive. We propose that aquatic hyphomycete communities can be used as sensitive and integrative indicators for freshwater quality...
  97. ncbi Flavipucine and brunnescin, two antibiotics from cultures of the mycophilic fungus Cladobotryum rubrobrunnescens
    C Wagner
    , Kaiserslautern, Bundesrepublik Deutschland
    Z Naturforsch C 50:358-64. 1995
    ..and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). The other metabolite, brunnescin (1), is a new tetrasubstituted furan derivative which exhibits antibacterial, antifungal and cytotoxic effects...
  98. ncbi Anti-angiogenic activity of terpestacin, a bicyclo sesterterpene from Embellisia chlamydospora
    Hye Jin Jung
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul 143-747, Korea
    J Antibiot (Tokyo) 56:492-6. 2003
  99. ncbi Stachybotrys chartarum: a fungus for our time
    Bruce B Jarvis
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Phytochemistry 64:53-60. 2003
    ..A related fungus, Memnoniella echinata also produces trichothecenes and the triprenylated phenolics. Herein the production of these compounds from cultures of the above are reviewed...
  100. ncbi Purification and characterization of a surface lectin from the nematode-trapping fungus Arthrobotrys oligospora
    S Rosen
    Department of Microbial Ecology, Lund University, Sweden
    J Gen Microbiol 138:2663-72. 1992
    ..About the same amount of the haemagglutinating protein was recovered from samples of vegetative mycelium and of mycelium containing nematode-trapping cells...
  101. ncbi [Inhibitory effect of antimicrobial preparation from lipids of marine fishes on tissue and microbial enzymes]
    T A Davletshina
    Pacific Research Fisheries Center (TINRO-Center, Vladivostok, 690950 Russia
    Prikl Biokhim Mikrobiol 39:676-80. 2003
    ..The inhibitory effect of this preparation on enzymes contributes to stabilization of hydrolytic processes in meat of hydrobionts and suppresses microorganism growth in storage...

Research Grants95

  1. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    Amos B Smith; Fiscal Year: 2010
    ..Our experience with discodermolide gives us great confidence in this area. ..
  2. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2007
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  3. Functions of Cryptococcus neoformans mating type loci
    Joseph Heitman; Fiscal Year: 2006
    ..These studies will provide insights into the role of MAT loci and sexual cycles in fungal differentiation and virulence. ..
  4. DEMOLITION AND ASTHMA IN CHICAGO PUBLIC HOUSING
    Samuel Dorevitch; Fiscal Year: 2006
    ....
  5. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  6. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2003
    ..We believe that this philosophy of "unified" synthetic strategies" will be amply demonstrated in this proposal. ..
  7. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2007
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  8. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  9. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2011
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  10. In vivo Regulation of Cytoplasmic Dynein
    Xin Xiang; Fiscal Year: 2009
    ..Our third aim is to create null-mutants of several proteins in the dynein complex to study their functions in dynein regulation, and identify novel dynein regulators by cloning additional nud genes. ..
  11. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2010
    ..The goal is to harness signaling cascades to develop novel antifungal therapies. ..
  12. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 2009
    ..Our experience with discodermolide gives us great confidence in this area. ..
  13. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....
  14. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...
  15. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 1991
    ..FK506 is therefore an important target for total synthesis, not only for its intrinsic synthetic challenge, but also due to its extrinsic worth to the field of medicine...
  16. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    AMOS SMITH; Fiscal Year: 1993
    ..We believe that this philosophy of "unified synthetic strategies" will be further developed by this proposal...
  17. SYNTHESIS OF CYCLOPENTENOID ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1980
    ..Once such features are identified the design of new and possibly more effective antitumor drugs should be feasible...
  18. IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 1999
    ..The Investigator s goals are to identify immunophilins, calcineurin, and their functions in C. neoformans to delineate a signal transduction pathway regulating pathogenesis and to define novel antifungal drug targets. ..
  19. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  20. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2010
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  21. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  22. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  23. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  24. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2009
    ..In particular, the role of genes encoding cell-cell communication molecules involved in the infectious process will be a focus. ..
  25. NOVEL ANTIFUNGAL DRUG TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 2005
    ..Our long term goal is to identify unique targets and develop novel antifungal drug therapies. ..
  26. ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITING
    Joseph Heitman; Fiscal Year: 2005
    ....
  27. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2007
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  28. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2007
    ....
  29. Genetics Training Grant-Year 26
    Joseph Heitman; Fiscal Year: 2007
    ..Here we seek to expand the NIH supported portion of the training program to a total of eight new students per year. ..
  30. ROLE OF CALCINEURIN IN CRYPTOCOCCUS NEOFORMANS VIRULENCE
    Joseph Heitman; Fiscal Year: 2002
    ..Maria Cardenas; biochemical and protein purification support and Dr. John Perfect; transformation of C. neoformans and virulence analysis) combine for a highly enthusiastic rating of this application. ..