podospora

Summary

Summary: A genus of ascomycete FUNGI in the order SORDARIALES, which is found on SOIL and herbivore dung (FECES).

Top Publications

  1. pmc Genome-wide gene expression profiling of fertilization competent mycelium in opposite mating types in the heterothallic fungus Podospora anserina
    Frédérique Bidard
    Univ Paris Sud, Institut de Génétique et Microbiologie UMR8621, Orsay, France
    PLoS ONE 6:e21476. 2011
  2. doi Functions and regulation of the Nox family in the filamentous fungus Podospora anserina: a new role in cellulose degradation
    Sylvain Brun
    UFR des Sciences du Vivant, Univ Paris 7 Denis Diderot, 75013 Paris, France
    Mol Microbiol 74:480-96. 2009
  3. ncbi Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
    C Q Scheckhuber
    Johann Wolfgang Goethe University, Institute of Molecular Biosciences, Max von Laue Str 9, 60438 Frankfurt, Germany
    Nat Cell Biol 9:99-105. 2007
  4. doi Mitochondrial recombination increases with age in Podospora anserina
    Anne D Van Diepeningen
    Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
    Mech Ageing Dev 131:315-22. 2010
  5. pmc The fungus-specific HET domain mediates programmed cell death in Podospora anserina
    M Paoletti
    Laboratoire de Génétique Moléculaire des Champignons, UMR 5095 CNRS et Université de Bordeaux 2, IBGC, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eukaryot Cell 6:2001-8. 2007
  6. ncbi Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina
    Heinz D Osiewacz
    Institute of Molecular Biosciences, Molecular Developmental Biology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Free Radic Res 40:1350-8. 2006
  7. doi The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility
    Sven J Saupe
    Non self recognition in fungi, Institut de Biochimie et de Génétique Cellulaire, UMR 5095, CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, Bordeaux Cedex, France
    Semin Cell Dev Biol 22:460-8. 2011
  8. ncbi Cell death by incompatibility in the fungus Podospora
    Bérangère Pinan-Lucarré
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS et Université de Bordeaux 2, Bordeaux, France
    Semin Cancer Biol 17:101-11. 2007
  9. pmc Suppression of mitochondrial DNA instability of autosomal dominant forms of progressive external ophthalmoplegia-associated ANT1 mutations in Podospora anserina
    Riyad El-Khoury
    Centre National de la Recherche Scientifique CNRS, Centre de Genetique Moleculaire, Gif sur Yvette F 91198, France
    Genetics 183:861-71. 2009
  10. doi Grafting as a method for studying development in the filamentous fungus Podospora anserina
    Philippe Silar
    Univ Paris Sud, Institut de Genetique et Microbiologie, CNRS UMR 8621, 91405 Orsay Cedex, France
    Fungal Biol 115:793-802. 2011

Research Grants

  1. Structural Investigations of the Prion Protein het-s
    Roland Riek; Fiscal Year: 2006
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
  4. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
  5. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
  6. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications179 found, 100 shown here

  1. pmc Genome-wide gene expression profiling of fertilization competent mycelium in opposite mating types in the heterothallic fungus Podospora anserina
    Frédérique Bidard
    Univ Paris Sud, Institut de Génétique et Microbiologie UMR8621, Orsay, France
    PLoS ONE 6:e21476. 2011
    ..The heterothallic fungus Podospora anserina serves as a model for understanding the basic features of mating-type control...
  2. doi Functions and regulation of the Nox family in the filamentous fungus Podospora anserina: a new role in cellulose degradation
    Sylvain Brun
    UFR des Sciences du Vivant, Univ Paris 7 Denis Diderot, 75013 Paris, France
    Mol Microbiol 74:480-96. 2009
    ..In this paper, we have identified a Podospora anserina mutant strain impaired for processes controlled by PaNox1 and PaNox2, the two Nox isoforms ..
  3. ncbi Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
    C Q Scheckhuber
    Johann Wolfgang Goethe University, Institute of Molecular Biosciences, Max von Laue Str 9, 60438 Frankfurt, Germany
    Nat Cell Biol 9:99-105. 2007
    ..fission protein conserved from yeast to humans, affects ageing in the two model systems we studied, Podospora anserina and Saccharomyces cerevisiae...
  4. doi Mitochondrial recombination increases with age in Podospora anserina
    Anne D Van Diepeningen
    Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
    Mech Ageing Dev 131:315-22. 2010
    ..A survey of wild-type isolates from a local population of the filamentous fungus Podospora anserina for the presence of seven optional mitochondrial introns indicated that mitochondrial recombination ..
  5. pmc The fungus-specific HET domain mediates programmed cell death in Podospora anserina
    M Paoletti
    Laboratoire de Génétique Moléculaire des Champignons, UMR 5095 CNRS et Université de Bordeaux 2, IBGC, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eukaryot Cell 6:2001-8. 2007
    ..The nonallelic het-C/het-E incompatibility system is the best-characterized incompatibility system in Podospora anserina...
  6. ncbi Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina
    Heinz D Osiewacz
    Institute of Molecular Biosciences, Molecular Developmental Biology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Free Radic Res 40:1350-8. 2006
    ..ageing in two fungal models, the unicellular ascomycete Saccharomyces cerevisiae and the filamentous ascomycete Podospora anserina...
  7. doi The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility
    Sven J Saupe
    Non self recognition in fungi, Institut de Biochimie et de Génétique Cellulaire, UMR 5095, CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, Bordeaux Cedex, France
    Semin Cell Dev Biol 22:460-8. 2011
    Het-s] is a prion from the filamentous fungus Podospora anserina and corresponds to a self-perpetuating amyloid aggregate of the HET-s protein...
  8. ncbi Cell death by incompatibility in the fungus Podospora
    Bérangère Pinan-Lucarré
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS et Université de Bordeaux 2, Bordeaux, France
    Semin Cancer Biol 17:101-11. 2007
    ..In Podospora anserina cell death by incompatibility is characterized by a dramatic vacuolar enlargement, induction of ..
  9. pmc Suppression of mitochondrial DNA instability of autosomal dominant forms of progressive external ophthalmoplegia-associated ANT1 mutations in Podospora anserina
    Riyad El-Khoury
    Centre National de la Recherche Scientifique CNRS, Centre de Genetique Moleculaire, Gif sur Yvette F 91198, France
    Genetics 183:861-71. 2009
    ..Here we show that the three adPEO-associated mutations equivalent to A114P, L98P, and V289M introduced into the Podospora anserina ANT1 ortholog dominantly cause severe growth defects, decreased reactive oxygen species production (ROS)..
  10. doi Grafting as a method for studying development in the filamentous fungus Podospora anserina
    Philippe Silar
    Univ Paris Sud, Institut de Genetique et Microbiologie, CNRS UMR 8621, 91405 Orsay Cedex, France
    Fungal Biol 115:793-802. 2011
    ..study the interplay between mycelium and multicellular fruiting bodies during maturation in the model ascomycete Podospora anserina. Data indicate that grafts need a competent mycelium to continue their ripening...
  11. doi Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina
    Heinz D Osiewacz
    Department of Biological Sciences and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University, 60438 Frankfurt Main, Germany
    Biochem Soc Trans 39:1488-92. 2011
    ..In the filamentous fungus Podospora anserina, a model in which organismal aging can conveniently be analysed, mitochondria play a central role...
  12. pmc Localization of HET-S to the cell periphery, not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity
    Vidhu Mathur
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Mol Cell Biol 32:139-53. 2012
    ..Amyloid toxicity is also associated with fungal prions. In Podospora anserina, the simultaneous presence of [Het-s] prion and its allelic protein HET-S causes cell death in a self-/..
  13. doi Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core
    Christian Wasmer
    Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    Science 319:1523-6. 2008
    ..fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus Podospora anserina...
  14. pmc WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family
    Damien Chevanne
    Laboratoire de Génétique Moléculaire des Champignons, IBGC, UMR 5095 Université Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, Bordeaux Cedex, France
    BMC Evol Biol 10:134. 2010
    ..In the fungus Podospora anserina, three genes controlling this allorecognition process het-d, het-e and het-r are paralogs belonging to ..
  15. pmc The crucial role of the Pls1 tetraspanin during ascospore germination in Podospora anserina provides an example of the convergent evolution of morphogenetic processes in fungal plant pathogens and saprobes
    Karine Lambou
    UMR 5240 CNRS UCB INSA Bayer CropScience, Microbiologie Adaptation et Pathogénie, Lyon Cedex 09, France
    Eukaryot Cell 7:1809-18. 2008
    ..We show here that Podospora anserina, a saprobic fungus lacking appressorium, contains PaPls1, a gene orthologous to known PLS1 genes...
  16. pmc Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain
    Céline Adam
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR 8621, Orsay, France
    PLoS ONE 7:e38138. 2012
    ..Despite the presence of ClpXP in the filamentous fungus Podospora anserina, deletion of the gene encoding the other matricial protease, PaLon1, leads to lethality at high and low ..
  17. pmc Cello-oligosaccharide oxidation reveals differences between two lytic polysaccharide monooxygenases (family GH61) from Podospora anserina
    Mathieu Bey
    INRA, UMR1163 BCF, Marseille, France
    Appl Environ Microbiol 79:488-96. 2013
    The genome of the coprophilic ascomycete Podospora anserina encodes 33 different genes encoding copper-dependent lytic polysaccharide monooxygenases (LPMOs) from glycoside hydrolase family 61 (GH61)...
  18. pmc Podospora anserina hemicellulases potentiate the Trichoderma reesei secretome for saccharification of lignocellulosic biomass
    Marie Couturier
    INRA, UMR 1163, Universités de Provence et de la Méditerranée, Laboratoire de Biotechnologie des Champignons Filamenteux, Marseille, France
    Appl Environ Microbiol 77:237-46. 2011
    ..a set of genes encoding putative polysaccharide-degrading enzymes were selected from the coprophilic fungus Podospora anserina using comparative genomics...
  19. pmc Systematic deletion of homeobox genes in Podospora anserina uncovers their roles in shaping the fruiting body
    Evelyne Coppin
    Universite Paris Sud, Institut de Génétique et Microbiologie UMR8621, Orsay, France
    PLoS ONE 7:e37488. 2012
    ..We identified all the homeobox genes in the filamentous ascomycete fungus Podospora anserina and constructed deletion mutants for each of these genes and for a number of gene combinations...
  20. pmc Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the aging model Podospora anserina
    Christian Q Scheckhuber
    Faculty for Biosciences, Molecular Developmental Biology, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University, Frankfurt, Germany
    PLoS ONE 6:e16620. 2011
    ..In the filamentous ascomycete Podospora anserina, an example for such a response is the induction of a nuclear-encoded and iron-dependent alternative ..
  21. pmc A non-Mendelian MAPK-generated hereditary unit controlled by a second MAPK pathway in Podospora anserina
    Hervé Lalucque
    Universite Paris Sud 11, Institut de Genetique et Microbiologie, Unité Mixte de Recherche Centre National de la Recherche Scientifique, 91405 Orsay Cedex, France
    Genetics 191:419-33. 2012
    The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration...
  22. pmc Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development
    Andrea Weil
    Goethe University, Faculty for Biosciences and Cluster of Excellence Macromolecular Complexes Frankfurt, Institute of Molecular Biosciences, Frankfurt, Germany
    Cell Cycle 10:4280-90. 2011
    ..protease is part of such a surveillance system and PaIAP is the putative ortholog in the fungal aging model Podospora anserina. Here we investigated the role of PaIAP in aging and development...
  23. pmc Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes
    Asen Daskalov
    Institut de Biochimie et de Génétique Cellulaire, UMR 5095, CNRS Université de Bordeaux 2, Bordeaux, France
    PLoS ONE 7:e34854. 2012
    Prions are infectious proteins propagating as self-perpetuating amyloid polymers. The [Het-s] prion of Podospora anserina is involved in a cell death process associated with non-self recognition...
  24. doi Two nuclear life cycle-regulated genes encode interchangeable subunits c of mitochondrial ATP synthase in Podospora anserina
    Michelle Dequard-Chablat
    Univ Paris Sud, Orsay, France
    Mol Biol Evol 28:2063-75. 2011
    ..Interestingly, we found that in Podospora anserina, subunit c is exclusively produced from two nuclear genes (PaAtp9-5 and PaAtp9-7), which display ..
  25. pmc The genome sequence of Podospora anserina, a classic model fungus
    Mathieu Paoletti
    Laboratoire de Génétique Moléculaire des Champignons, IBGC UMR CNRS 5095, Universite de Bordeaux 2, rue Camille Saint Saens, Bordeaux F 33077, France
    Genome Biol 9:223. 2008
    The completed genome sequence of the coprophilous fungus Podospora anserina increases the sampling of fungal genomes...
  26. ncbi Two NADPH oxidase isoforms are required for sexual reproduction and ascospore germination in the filamentous fungus Podospora anserina
    Fabienne Malagnac
    Institut de Genetique et Microbiologie, UMR 8621, Bat 400, Université de Paris XI, 91405 Orsay Cedex, France
    Fungal Genet Biol 41:982-97. 2004
    ..we demonstrate the crucial role of these enzymes in the control of two key steps of the filamentous fungus Podospora anserina life cycle...
  27. doi Podospora anserina: a model organism to study mechanisms of healthy ageing
    Christian Q Scheckhuber
    Cluster of Excellence Macromolecular Complexes and Faculty for Biosciences, Molecular Developmental Biology, Johann Wolfgang Goethe University, Max von Laue Str 9, 60438, Frankfurt Main, Germany
    Mol Genet Genomics 280:365-74. 2008
    The filamentous ascomycete Podospora anserina has been extensively studied as an experimental ageing model for more than 50 years...
  28. doi Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening
    Sandra Zintel
    Institute of Molecular Biosciences and Cluster of Excellence Macromolecular Complexes, Department of Biosciences, J W Goethe University, Max von Laue Strasse 9, Frankfurt am Main, Germany
    Exp Gerontol 45:525-32. 2010
    The fungal aging model Podospora anserina contains three superoxide dismutases (SODs) in different cellular compartments...
  29. pmc Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts
    Christian Q Scheckhuber
    Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    PLoS ONE 4:e4919. 2009
    In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process...
  30. doi Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium
    Ingmar Strobel
    Department of Biological Sciences and Cluster of Excellence Macromolecular Complexes, Institute of Molecular Biosciences, J W Goethe University, Frankfurt, Germany
    Curr Genet 55:175-84. 2009
    Carotenoids have been identified in the fungus Podospora anserina and a parallel pathway to neurosporene and beta-carotene was established. Three genes for the beta-carotene branch have been cloned and their function elucidated...
  31. ncbi Integration of a pAL2-1 homologous mitochondrial plasmid associated with life span extension in Podospora anserina
    M F P M Maas
    CNRS, Centre de Genetique Moleculaire, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Fungal Genet Biol 44:659-71. 2007
    We isolated and characterized a novel spontaneous longevity mutant of Podospora anserina strain Wa32 carrying one of the pAL2-1 homologous mitochondrial plasmids...
  32. doi Peroxisomal ABC transporters and beta-oxidation during the life cycle of the filamentous fungus Podospora anserina
    Stéphanie Boisnard
    Univ Paris Sud 11, CNRS, UMR8621, Institut de Genetique et Microbiologie, 91405 Orsay, France
    Fungal Genet Biol 46:55-66. 2009
    ..In order to test their function in a fungus life cycle, we deleted the two Podospora anserina peroxisomal ABC transporter pABC1 and pABC2 genes as well as the three genes involved in peroxisomal (..
  33. ncbi Characterization of IDI-4, a bZIP transcription factor inducing autophagy and cell death in the fungus Podospora anserina
    Karine Dementhon
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, 33077 Bordeaux Cedex, France
    Mol Microbiol 53:1625-40. 2004
    ..This phenomenon is referred to as heterokaryon incompatibility. In Podospora anserina, this cell death reaction was found to be associated with the transcriptional induction of a set of ..
  34. doi The peroxisome RING-finger complex is required for meiocyte formation in the fungus Podospora anserina
    Leonardo Peraza-Reyes
    Univ Paris Sud, CNRS UMR8621, Institut de Genetique et Microbiologie, 91405 Orsay, France
    Traffic 9:1998-2009. 2008
    ..Peroxisomes are involved in a variety of metabolic pathways and developmental processes. In the filamentous fungus Podospora anserina, absence of different peroxins implicated in peroxisome matrix protein import leads to different ..
  35. pmc Accelerated cell death in Podospora autophagy mutants
    Bérangère Pinan-Lucarré
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS et Université de Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eukaryot Cell 4:1765-74. 2005
    ..Cell death by incompatibility is characterized by a dramatic vacuolar enlargement and cell lysis. In Podospora anserina, autophagy is induced early during this cell death reaction...
  36. pmc Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae
    Josphat C Matasyoh
    Department of Chemistry, Egerton University, PO Box 536, Egerton, Kenya
    Parasitol Res 108:561-6. 2011
    In a screening for natural products with mosquito larvicidal activities, the endophytic fungus Podospora sp. isolated from the plant Laggera alata (Asteraceae) was conspicuous...
  37. pmc Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy
    Naoko Mizuno
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:3252-7. 2011
    HET-s is a prion protein of the fungus Podospora anserina which, in the prion state, is active in a self/nonself recognition process called heterokaryon incompatibility. Its prionogenic properties reside in the C-terminal "prion domain...
  38. doi Cyclophilin D links programmed cell death and organismal aging in Podospora anserina
    Diana Brust
    Johann Wolfgang Goethe University, Institute of Molecular Biosciences, Frankfurt, Germany
    Aging Cell 9:761-75. 2010
    ..CYPD abundance increases during aging in mammalian tissues and in the aging model organism Podospora anserina. Here, we show that treatment of the P...
  39. doi The transcriptional response to the inactivation of the PaMpk1 and PaMpk2 MAP kinase pathways in Podospora anserina
    Frédérique Bidard
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR8621 Orsay, France
    Fungal Genet Biol 49:643-52. 2012
    Transcription pattern during mycelium growth of Podospora anserina was assayed by microarray analysis in wild type and in mutants affected in the MAP kinase genes PaMpk1 and PaMpk2 and in the NADPH oxidase gene PaNox1...
  40. pmc PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress
    Sandra Zintel
    Institute of Molecular Biosciences and Cluster of Excellence Macromolecular Complexes, Department of Biosciences, J W Goethe University, Frankfurt am Main, Germany
    Aging (Albany NY) 3:768-81. 2011
    A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles...
  41. doi Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging
    Mathis Müller-Ohldach
    Faculty for Biosciences and Cluster of Excellence Macromolecular Complexes, Institute of Molecular Biosciences, Molecular Developmental Biology, Johann Wolfgang Goethe University, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Mech Ageing Dev 132:33-42. 2011
    ..Here we report that PaPARP, the single protein with a PARP catalytic domain, in the fungal aging model Podospora anserina, indeed displays a NAD(+)-dependent poly(ADP-ribose) polymerase activity...
  42. doi The importomer peroxins are differentially required for peroxisome assembly and meiotic development in Podospora anserina: insights into a new peroxisome import pathway
    Leonardo Peraza-Reyes
    Institut de Genetique et Microbiologie, Univ Paris Sud, UMR8621, F 91405 Orsay, France
    Mol Microbiol 82:365-77. 2011
    ..In the fungus Podospora anserina, the RING-finger peroxins are crucial for meiocyte formation, while PEX5, PEX7 or the docking peroxin ..
  43. pmc High natural prevalence of a fungal prion
    Alfons J M Debets
    Laboratory of Genetics, Wageningen University, 6708 PB Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 109:10432-7. 2012
    ..Het-s] is a prion of the fungus Podospora anserina...
  44. ncbi OXPHOS Supercomplexes: respiration and life-span control in the aging model Podospora anserina
    Frank Krause
    Physical Biochemistry, Department of Chemistry, Darmstadt University of Technology, Germany
    Ann N Y Acad Sci 1067:106-15. 2006
    ..of the respiratory chain of a wild-type strain and of two long-lived mutants of the filamentous fungus Podospora anserina. This aging model is able to respire by either the standard or the alternative pathway...
  45. ncbi Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina
    Séverine Lorin
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Biochim Biophys Acta 1757:604-10. 2006
    The filamentous fungus Podospora anserina has a limited lifespan. In this organism, aging is systematically associated to mitochondrial DNA instability...
  46. doi Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina
    Heinz D Osiewacz
    Institute of Molecular Biosciences, Faculty for Biosciences and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University, Frankfurt, Germany
    Ann N Y Acad Sci 1197:54-66. 2010
    ..has unraveled a number of molecular pathways that are involved in controlling aging of the fungal model system Podospora anserina...
  47. doi Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity
    Christian Wasmer
    Physical Chemistry, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    J Mol Biol 402:311-25. 2010
    ..The domain FgHET-s(218-289), which corresponds to the prion domain in HET-s from Podospora anserina, forms amyloid fibrils in vitro and is able to efficiently cross-seed HET-s(218-289) prion formation...
  48. doi Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension
    Diana Brust
    Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt, Germany
    Curr Genet 56:225-35. 2010
    Wild-type strains of the ascomycete Podospora anserina are characterized by a limited lifespan...
  49. doi Gene deletion and allelic replacement in the filamentous fungus Podospora anserina
    Riyad El-Khoury
    CNRS, Centre de Genetique Moleculaire, UPR 2167, Avenue de la Terrasse, Bat 26, 91198, Gif sur Yvette, France
    Curr Genet 53:249-58. 2008
    ..However, this event is rare in organisms like the filamentous fungus Podospora anserina...
  50. doi Increasing organismal healthspan by enhancing mitochondrial protein quality control
    Karin Luce
    Johann Wolfgang Goethe University, Institute of Molecular Biosciences, Frankfurt, Germany
    Nat Cell Biol 11:852-8. 2009
    ..Here we describe the regulation of Podospora anserina LON (PaLON) levels, an AAA(+) family serine protease localized in the matrix fraction of mitochondria...
  51. pmc Correlation of structural elements and infectivity of the HET-s prion
    Christiane Ritter
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:844-8. 2005
    ..is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...
  52. ncbi Peroxide accumulation and cell death in filamentous fungi induced by contact with a contestant
    Philippe Silar
    Institut de Genetique et Microbiologie, UMR CNRS 8621, Universite de Paris Sud, 91405 Orsay Cedex, France
    Mycol Res 109:137-49. 2005
    b>Podospora anserina and Coprinopsis cinerea (syn. Coprinus cinereus) are endowed with a defence system able to differentiate self vs. non-self and involving the generation of peroxide...
  53. ncbi A mutation in the gene encoding cytochrome c1 leads to a decreased ROS content and to a long-lived phenotype in the filamentous fungus Podospora anserina
    Carole H Sellem
    Centre de Genetique Moleculaire, UPR 2167, CNRS, 1 Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Fungal Genet Biol 44:648-58. 2007
    We present here the properties of a complex III loss-of-function mutant of the filamentous fungus Podospora anserina...
  54. doi Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions
    Birgit Kunstmann
    Department of Biological Sciences and Cluster of Excellence Macromolecular Complexes, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany
    Aging Cell 7:651-62. 2008
    ..methyltransferase previously described to increase in abundance in total protein extracts during aging of Podospora anserina is demonstrated to accumulate in the mitochondrial cell fraction of senescent cultures...
  55. pmc The genome sequence of the model ascomycete fungus Podospora anserina
    Eric Espagne
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR8621, 91405 Orsay Cedex, France
    Genome Biol 9:R77. 2008
    The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual development.
  56. pmc A short history of small s: a prion of the fungus Podospora anserina
    Sven J Saupe
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, Bordeaux Cedex 33077, France
    Prion 1:110-5. 2007
    ..The [Het-s] cytoplasmic genetic element of the filamentous fungus Podospora anserina, was originally identified in 1952 and recognized as a prion nearly half a century later...
  57. pmc Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan
    Christian Q Scheckhuber
    Faculty for Biosciences and Cluster of Excellence Macromolecular Complexes, Molecular Developmental Biology, Goethe University, D 60438 Frankfurt am Main, Germany
    Aging (Albany NY) 2:969-80. 2010
    ..Overall, our results identify the up-regulation of both components of the glyoxalase system as an effective intervention to increase lifespan in P. anserina...
  58. pmc A mitotically inheritable unit containing a MAP kinase module
    Sébastien Kicka
    Institut de Genetique et Microbiologie, Unite Mixte de Recherche 8621, Centre National de la Recherche Scientifique, Université de Paris Sud 11, Batiment 400, F 91405 Orsay cedex, France
    Proc Natl Acad Sci U S A 103:13445-50. 2006
    ..Here, we provide further evidence that in the filamentous fungus Podospora anserina, a MAP kinase cascade is probably able to self-activate and generate C, a hereditary unit that bears ..
  59. pmc PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration
    Fabienne Malagnac
    Institut de Genetique et Microbiologie, UMR CNRS Université de Paris 11, UPS Bât 400, 91405 Orsay Cedex, France
    Eukaryot Cell 6:2323-31. 2007
    ..Genes encoding thioredoxins were found by searching the complete genome sequence of the filamentous ascomycete Podospora anserina...
  60. ncbi Identification of PaPKS1, a polyketide synthase involved in melanin formation and its use as a genetic tool in Podospora anserina
    Evelyne Coppin
    Institut de Genetique et Microbiologie, CNRS UMR 8621 Bât 400, Université de Paris 11, 91405 Orsay Cedex, France
    Mycol Res 111:901-8. 2007
    In the filamentous fungus Podospora anserina, many pigmentation mutations map to the median region of the complex locus '14', called segment '29'...
  61. ncbi Non-mendelian inheritance of the HET-s prion or HET-s prion domains determines the het-S spore killing system in Podospora anserina
    Henk J P Dalstra
    Laboratory of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Fungal Genet Biol 42:836-47. 2005
    Two alleles of the het-s/S locus occur naturally in the filamentous fungus Podospora anserina, het-s and het-S...
  62. ncbi A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina
    Andrea Hamann
    Biozentrum, Botanisches Institut, Marie Curie Str 9, 60439, Frankfurt, Germany
    Curr Genet 48:270-5. 2005
    Deletion of genes in Podospora anserina via conventional methods is an inefficient and time-consuming process since homologous recombination occurs normally only at low frequency (about 1%)...
  63. doi Monitoring autophagy in the filamentous fungus Podospora anserina
    Bérangère Pinan-Lucarré
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux 2 et CNRS, Bordeaux, France
    Methods Enzymol 451:251-70. 2008
    Autophagy has been monitored in the filamentous fungus Podospora anserina using electron, light, and fluorescence microscopy...
  64. ncbi Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany
    Exp Gerontol 42:887-98. 2007
    ..a differential comparison of mitochondrial proteins from young and senescent strains of the fungal ageing model Podospora anserina, from brains of young (5 months) vs...
  65. ncbi Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina
    Andrea Hamann
    Department of Biosciences, Institute of Molecular Biosciences, J W Goethe University, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Mol Microbiol 65:948-58. 2007
    b>Podospora anserina is a filamentous fungus with a limited lifespan. After a strain-specific period of growth, cultures turn to senescence and ultimately die. Here we provide evidence that the last step in the ageing of P...
  66. doi Regulation of mitochondrial dynamics--characterization of fusion and fission genes in the ascomycete Podospora anserina
    Christian Q Scheckhuber
    Johann W Goethe Universität, Institut für Molekulare Biowissenschaften, Frankfurt am Main, Germany
    Biotechnol J 3:781-90. 2008
    The filamentous ascomycete Podospora anserina is a model system for studying aging, a complex process that is regulated by multiple factors. Among these, mitochondria were shown to be of crucial importance...
  67. pmc DNA-binding specificity of the IDI-4 basic leucine zipper factor of Podospora anserina defined by systematic evolution of ligands by exponential enrichment (SELEX)
    Karine Dementhon
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 33077 Bordeaux Cedex, France
    Eukaryot Cell 4:476-83. 2005
    ..In Podospora anserina, autophagy is engaged during cell death by incompatibility and a number of genes are induced at the ..
  68. doi Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family
    Damien Chevanne
    Laboratoire de Génétique Moléculaire des Champignons, IBGC, UMR5095, Université Victor Segalen Bordeaux2 et CNRS, 1 rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    Curr Genet 55:93-102. 2009
    ..In Podospora anserina, three non-allelic incompatibility systems have been genetically defined involving interactions between ..
  69. pmc The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress
    Birgit Kunstmann
    Department of Biological Sciences and Cluster of Excellence Macromolecular Complexes, Institute of Molecular Biosciences, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
    Aging (Albany NY) 1:328-34. 2009
    ..The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix...
  70. pmc Altering a gene involved in nuclear distribution increases the repeat-induced point mutation process in the fungus Podospora anserina
    Khaled Bouhouche
    Institut de Genetique et Microbiologie, UMR CNRS Université 8621, Universite Paris Sud, F 91405 Orsay cedex, France
    Genetics 167:151-9. 2004
    ..Both are active over the sexual cycle of some filamentous fungi, e.g., Neurospora crassa and Podospora anserina...
  71. pmc A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing
    Mette Soerensen
    Danish Centre for Molecular Gerontology and Danish Aging Research Center, Aarhus University, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Mech Ageing Dev 130:487-96. 2009
    ..In the sexually reproducing ascomycete Podospora anserina ageing is, as in other eukaryotes, associated with mtDNA instability and mitochondrial dysfunction...
  72. doi Life span extension by dietary restriction is reduced but not abolished by loss of both SIR2 and HST2 in Podospora anserina
    Antoine Boivin
    Centre de Genetique Moleculaire, UPR 2167, Gif sur Yvette F 91198, France
    Mech Ageing Dev 129:714-21. 2008
    ..In this paper, we studied the relationship between SIR2 and DR in the filamentous fungus Podospora anserina. We show that the loss of PaSir2, PaHst2 or PaPnc1 does not alter life span under standard conditions...
  73. pmc Mutations in two zinc-cluster proteins activate alternative respiratory and gluconeogenic pathways and restore senescence in long-lived respiratory mutants of Podospora anserina
    Carole H Sellem
    Universite Paris Sud, Orsay F 91405, France
    Genetics 182:69-78. 2009
    In Podospora anserina, inactivation of the respiratory chain results in a spectacular life-span extension. This inactivation is accompanied by the induction of the alternative oxidase...
  74. doi Calorie restriction in the filamentous fungus Podospora anserina
    Anne D Van Diepeningen
    Laboratory of Genetics, Plant Sciences, Wageningen University, Wageningen, The Netherlands
    Exp Gerontol 45:516-24. 2010
    ..b>Podospora anserina is one of the few known ageing filamentous fungi and the ageing process and concomitant degeneration of ..
  75. doi Molecular basis of and interference into degenerative processes in fungi: potential relevance for improving biotechnological performance of microorganisms
    Christian Q Scheckhuber
    Institute of Molecular Biosciences, Faculty for Biosciences and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University, Frankfurt, Germany
    Appl Microbiol Biotechnol 85:27-35. 2009
    ..Studying the mechanistic basis of degenerative processes in the filamentous ascomycete Podospora anserina and in other systems demonstrated that mitochondria play a key role in the expression of degenerative ..
  76. doi Fungal incompatibility: evolutionary origin in pathogen defense?
    Mathieu Paoletti
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, 33077 Bordeaux Cedex, France
    Bioessays 31:1201-10. 2009
    ..In Podospora anserina, the genes controlling this process belong to a gene family encoding STAND proteins with an N-terminal ..
  77. pmc The function of the coding sequences for the putative pheromone precursors in Podospora anserina is restricted to fertilization
    Evelyne Coppin
    Institut de Genetique et Microbiologie, UMR 8621 CNRS, Universite Paris Sud, Orsay, France
    Eukaryot Cell 4:407-20. 2005
    We cloned the pheromone precursor genes of Podospora anserina in order to elucidate their role in the biology of this fungus...
  78. pmc Interaction between the oxa1 and rmp1 genes modulates respiratory complex assembly and life span in Podospora anserina
    Carole H Sellem
    Centre de Génétique Moléculaire UPR 2167, Associated with the University of Paris Sud 11 CNRS, Gif sur Yvette, France
    Genetics 169:1379-89. 2005
    ..deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina...
  79. ncbi IDC1, a pezizomycotina-specific gene that belongs to the PaMpk1 MAP kinase transduction cascade of the filamentous fungus Podospora anserina
    Corinne Jamet-Vierny
    Institut de Genetique et Microbiologie, UMR CNRS, Université de Paris 11, UPS Bât 400, 91405 Orsay Cedex, France
    Fungal Genet Biol 44:1219-30. 2007
    ..In addition, heterokaryon construction shows that IDC1 is necessary together with PaNox1 in the perithecial envelope but not in the dikaryon resulting from fertilization...
  80. ncbi Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina
    Ricardo Gredilla
    Institut für Molekulare Biowissenschaften, Johann Wolfgang Goethe Universitat, Molekulare Entwicklungsbiologie, Marie Curie Strasse 9, 60439 Frankfurt am Main, Germany
    Exp Gerontol 41:439-47. 2006
    In the filamentous fungus Podospora anserina a central role of mitochondria in the control of aging has been repeatedly demonstrated...
  81. ncbi The peroxisomal import proteins PEX2, PEX5 and PEX7 are differently involved in Podospora anserina sexual cycle
    Crystel Bonnet
    Institut de Genetique et Microbiologie, UMR CNRS 8621, Bat 400, Universite Paris Sud, 91405 Orsay Cedex, France
    Mol Microbiol 62:157-69. 2006
    ..shown previously that PEX2 deficiency leads to an impairment of meiotic commitment in the filamentous fungus Podospora anserina...
  82. ncbi Mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked beta-solenoid model of HET-s prion fibrils
    Anindito Sen
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:5545-50. 2007
    ..In its prion form, the HET-s protein of Podospora anserina participates in a fungal self/non-self recognition phenomenon called heterokaryon incompatibility...
  83. ncbi Identification and biochemical analysis of a mitochondrial endonuclease of Podospora anserina related to curved-DNA binding proteins
    Patricia Laquel-Robert
    CNRS UMR 5097 Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Biochim Biophys Acta 1770:527-42. 2007
    We purified and characterized previously from Podospora anserina mitochondria an endonuclease, active on single-stranded, double-stranded and flap DNA, with RNAse H activity, named P49 according to the major 49 kDa band observed on SDS-..
  84. pmc Role of Hsp104 in the propagation and inheritance of the [Het-s] prion
    Laurent Malato
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, Unité Mixte de Recherche 5095 Centre National de la Recherche Scientifique Université de Bordeaux 2, 33077 Bordeaux Cedex, France
    Mol Biol Cell 18:4803-12. 2007
    ..In addition in yeast, Hsp104 was found to be required for prion propagation. Herein, we analyze the role of Podospora anserina Hsp104 (PaHsp104) in the formation and propagation of the [Het-s] prion...
  85. ncbi The sequences appended to the amyloid core region of the HET-s prion protein determine higher-order aggregate organization in vivo
    Axelle Balguerie
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 33077 Bordeaux, France
    J Cell Sci 117:2599-610. 2004
    The [Het-s] prion of the fungus Podospora anserina propagates as a self-perpetuating amyloid form of the HET-s protein...
  86. ncbi Genetic control of an epigenetic cell degeneration syndrome in Podospora anserina
    Vicki Haedens
    Institut de Genetique et Microbiologie, UMR 8621 CNRS UPS, 91405 Orsay Cedex, France
    Fungal Genet Biol 42:564-77. 2005
    ..or indirectly control Crippled Growth (CG), an epigenetic cell degeneration of the filamentous ascomycete Podospora anserina...
  87. ncbi Prion and non-prion amyloids of the HET-s prion forming domain
    Raimon Sabate
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, 33077 Bordeaux Cedex, France
    J Mol Biol 370:768-83. 2007
    HET-s is a prion protein of the fungus Podospora anserina...
  88. pmc A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast
    Vibha Taneja
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell 27:67-77. 2007
    ..Fungi also have prions. While yeast prions depend upon glutamine/asparagine (Q/N)-rich regions, the Podospora anserina HET-s and PrP prion proteins lack such sequences...
  89. pmc Prions of fungi: inherited structures and biological roles
    Reed B Wickner
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Nat Rev Microbiol 5:611-8. 2007
    ....
  90. ncbi Structural biology: prying into prions
    Christopher M Dobson
    Nature 435:747-9. 2005
  91. ncbi Probing the structure of the infectious amyloid form of the prion-forming domain of HET-s using high resolution hydrogen/deuterium exchange monitored by mass spectrometry
    Alexis Nazabal
    Institut Europeen de Chimie et Biologie, CNRS UMR 5144, 2 rue Robert Escarpit, 33600 Pessac, France
    J Biol Chem 280:13220-8. 2005
    The HET-s prion protein of Podospora anserina represents a valuable model system to study the structural basis of prion propagation. In this system, prion infectivity can be generated in vitro from a recombinant protein...
  92. pmc Asexual cephalosporin C producer Acremonium chrysogenum carries a functional mating type locus
    Stefanie Pöggeler
    Abteilung Genetik Eukaryotischer Mikroorganismen, Institut fur Mikrobiologie und Genetik, Georg August Universitat Gottingen, Grisebachstr 8, 37077 Gottingen, Germany
    Appl Environ Microbiol 74:6006-16. 2008
    ..AcMAT1-1 locus, the entire MAT locus was transferred into a MAT deletion strain of the heterothallic ascomycete Podospora anserina (the PaDeltaMAT strain). After fertilization with a P...
  93. doi On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2
    Raimon Sabate
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux 2, 1 rue Camille St Saëns, 33077 Bordeaux Cedex, France
    J Struct Biol 162:387-96. 2008
    ..Finally, we found that ThT acquires chiral properties when it is fibril-bound. These results are discussed in relation to the different ThT-binding modes that have been proposed...
  94. ncbi Podospora anserina target of rapamycin
    Bérangère Pinan-Lucarré
    Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS et Université de Bordeaux 2, France
    Curr Genet 50:23-31. 2006
    We have isolated the Podospora anserina TOR gene. The PaTOR protein displayed strong identities with TOR proteins from other eukaryotes especially in the FRB domain and the kinase domain...
  95. ncbi A novel in vitro filter trap assay identifies tannic acid as an amyloid aggregation inducer for HET-s
    Mona Boyé-Harnasch
    Institut de Biochimie et Génétique Cellulaire, 1 rue Camille St Saëns, CNRS UMR 5095, 33077 Bordeaux Cedex, France
    J Biotechnol 125:222-30. 2006
    ..We chose the recombinant purified prion protein HET-s from Podospora anserina as a reference...
  96. pmc Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures
    Reed B Wickner
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Bioessays 30:955-64. 2008
    ..The prions [URE3] and [PSI+] of yeast are disease agents of Saccharomyces cerevisiae while [Het-s] of Podospora anserina may serve a normal cellular function...
  97. ncbi Methods for the in vivo and in vitro analysis of [Het-s] prion infectivity
    Laura Benkemoun
    Laboratoire de Génétique Moléculaire des Champignons, IBGC UMR CNRS 5095, Universite de Bordeaux 2, Bordeaux, France
    Methods 39:61-7. 2006
    Prions have been described in mammals and fungi. The [Het-s] infectious genetic element of the filamentous fungus Podospora anserina is the prion form of the HET-s protein...
  98. ncbi Prions of yeast are genes made of protein: amyloids and enzymes
    R B Wickner
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Cold Spring Harb Symp Quant Biol 69:489-96. 2004
  99. ncbi The formation of bioactive amyloid species by prion proteins in vitro and in cells
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Neurosci Lett 406:200-4. 2006
    ..In this report, we show that the infectious amyloid species of the prion protein HET-s of the filamentous fungus Podospora anserina, like other amyloidogenic proteins, also enhances MTT formazan exocytosis...
  100. ncbi Prion genetics: new rules for a new kind of gene
    Reed B Wickner
    Laboraory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Annu Rev Genet 38:681-707. 2004
    ..A recently identified prion is based on obligatory self-activation of an enzyme in trans. Although prions can be detrimental, they may also be beneficial to their hosts...
  101. ncbi Prions
    I S Shkundina
    Russian Cardiology Research Industrial Center, 3 ya Cherepkovskaya ul 15A, 121552 Moscow, Russia
    Biochemistry (Mosc) 72:1519-36. 2007
    ..Discovery of prions in lower eukaryotes, the yeast Saccharomyces cerevisiae and fungus Podospora anserina, suggests that prions have wider significance...

Research Grants17

  1. Structural Investigations of the Prion Protein het-s
    Roland Riek; Fiscal Year: 2006
    ..Prion proteins have also been identified in lower eukaryotes, namely yeast and the filamentous fungus Podospora anserina...
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  4. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  5. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  6. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..