treponema pallidum

Summary

Summary: The causative agent of venereal and non-venereal syphilis as well as yaws.

Top Publications

  1. ncbi Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies
    Neuza Satomi Sato
    Seção de Sorologia, Instituto Adolfo Lutz, Sao Paulo, SP, Brasil
    Rev Inst Med Trop Sao Paulo 45:319-22. 2003
  2. pmc Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence
    Darina Čejková
    Department of Biology, Masaryk University, Brno, Czech Republic
    PLoS Negl Trop Dis 6:e1471. 2012
  3. pmc TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
    Mol Microbiol 80:1496-515. 2011
  4. pmc Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis
    Lorenzo Giacani
    Department of Medicine, Box 359779, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Infect Immun 75:104-12. 2007
  5. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
  6. pmc Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
    Infect Genet Evol 12:191-202. 2012
  7. pmc Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum
    David L Cox
    Division of STD Prevention, Laboratory Reference and Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Infect Immun 78:5178-94. 2010
  8. pmc Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays
    Petra Matejková
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
    BMC Microbiol 8:76. 2008
  9. pmc Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain
    Lorenzo Giacani
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98195, USA
    J Bacteriol 192:2645-6. 2010
  10. pmc Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions
    Lenka Mikalová
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 5:e15713. 2010

Research Grants

  1. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
  2. Crane - CheA and its Complexes
    Brian R Crane; Fiscal Year: 2010
  3. Crane - CheA and its Complexes
    BRIAN CRANE; Fiscal Year: 2009
  4. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2000
  5. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
  6. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 1999
  7. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2007
  8. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2005
  9. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2004
  10. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006

Detail Information

Publications254 found, 100 shown here

  1. ncbi Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies
    Neuza Satomi Sato
    Seção de Sorologia, Instituto Adolfo Lutz, Sao Paulo, SP, Brasil
    Rev Inst Med Trop Sao Paulo 45:319-22. 2003
    ..for detecting specific antibodies to Treponema pallidum was evaluated against serum samples from patients with clinical, epidemiological and serological diagnosis ..
  2. pmc Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence
    Darina Čejková
    Department of Biology, Masaryk University, Brno, Czech Republic
    PLoS Negl Trop Dis 6:e1471. 2012
    The yaws treponemes, Treponema pallidum ssp. pertenue (TPE) strains, are closely related to syphilis causing strains of Treponema pallidum ssp. pallidum (TPA)...
  3. pmc TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
    Mol Microbiol 80:1496-515. 2011
    Definitive identification of Treponema pallidum rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in T...
  4. pmc Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis
    Lorenzo Giacani
    Department of Medicine, Box 359779, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Infect Immun 75:104-12. 2007
    Transcriptional analysis of the tpr genes in Treponema pallidum subsp. pallidum (referred to here as simply T...
  5. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
    ..denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome ..
  6. pmc Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
    Infect Genet Evol 12:191-202. 2012
    Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively...
  7. pmc Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum
    David L Cox
    Division of STD Prevention, Laboratory Reference and Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Infect Immun 78:5178-94. 2010
    b>Treponema pallidum reacts poorly with the antibodies present in rabbit and human syphilitic sera, a property attributed to the paucity of proteins in its outer membrane...
  8. pmc Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays
    Petra Matejková
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
    BMC Microbiol 8:76. 2008
    Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood...
  9. pmc Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain
    Lorenzo Giacani
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98195, USA
    J Bacteriol 192:2645-6. 2010
    In syphilis research, the Nichols strain of Treponema pallidum, isolated in 1912, has been the most widely studied. Recently, important differences among T...
  10. pmc Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions
    Lenka Mikalová
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 5:e15713. 2010
    ..p. pallidum and T. p. pertenue strains. These regions of sequence divergence could be used for the molecular detection and discrimination of syphilis and yaws strains...
  11. pmc Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection
    David Smajs
    Human Genome Sequencing Center, University of Texas Houston Medical School, Houston, Texas, USA
    J Bacteriol 187:1866-74. 2005
    RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T...
  12. pmc Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A
    Michal Strouhal
    Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    Infect Immun 75:5859-66. 2007
    ..genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp...
  13. pmc Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum
    Brandon T Leader
    Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
    Infect Immun 71:6054-7. 2003
    Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection...
  14. pmc Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS Negl Trop Dis 6:e1698. 2012
    In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical...
  15. doi Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century
    Arlene C Sena
    Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Infect Dis 51:700-8. 2010
    The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests...
  16. pmc Preliminary evaluation of an immunochromatographic strip test for specific Treponema pallidum antibodies
    Pinar Zarakolu
    Section of Infectious Diseases, Department of Medicine, School of Medicine, Hacettepe University, Ankara, Turkey
    J Clin Microbiol 40:3064-5. 2002
    We evaluated a prototype immunochromatographic strip (ICS) test for qualitative detection of Treponema pallidum antibodies in 353 sera from 157 patients...
  17. pmc TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
    Arvind Anand
    Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 194:2321-33. 2012
    Identification of Treponema pallidum rare outer membrane proteins (OMPs) has been a longstanding objective of syphilis researchers...
  18. ncbi Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema
    R R Gray
    Department of Anthropology, University of Florida, USA
    Mol Biol Evol 23:2220-33. 2006
    We investigated the evolution of 6 genes from the Treponema pallidum repeat (tpr) gene family, which encode potential virulence factors and are assumed to have evolved through gene duplication and gene conversion events...
  19. pmc Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response
    A Centurion-Lara
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Exp Med 189:647-56. 1999
    ..pallidum. This gene family is hypothesized to be central to pathogenesis and immunity during syphilis infection...
  20. ncbi Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92
    C E Cameron
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 181:1401-13. 2000
    By means of a differential screening technique, a 92-kDa antigen, designated Tp92, was identified from Treponema pallidum subspecies pallidum...
  21. ncbi Syphilis: reemergence of an old adversary
    Jennifer R Chao
    Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 113:2074-9. 2006
    ..To describe the clinical findings in 4 patients with ocular syphilis and to provide a review of the recent rise in syphilis cases in the United States, along with a brief description of current diagnosis and treatment guidelines...
  22. pmc Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis
    Christina M Marra
    Departments of Neurology, University of Washington School of Medicine, Seattle, Washington 98104 2499, USA
    J Infect Dis 202:1380-8. 2010
    ..Strain typing is a tool for determining the diversity and epidemiology of infections...
  23. pmc A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin
    Mary Beth Brinkman
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Infect Immun 76:1848-57. 2008
    The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp...
  24. pmc Molecular differentiation of Treponema pallidum subspecies
    Arturo Centurion-Lara
    Department of Medicine, University of Washington, Seattle, 98195, USA
    J Clin Microbiol 44:3377-80. 2006
    b>Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test...
  25. pmc Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains
    C E Cameron
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 67:3168-70. 1999
    Previous investigations have demonstrated that immunization with Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase significantly protects rabbits from subsequent treponeme challenge...
  26. pmc Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcers
    K A Orle
    Roche Molecular Systems, Alameda, California 94501, USA
    J Clin Microbiol 34:49-54. 1996
    ..detection was devised for the simultaneous amplification of DNA targets from Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV) types 1 and 2...
  27. pmc Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates
    Rebecca E LaFond
    Departments of Pathobiology, University of Washington, Seattle, WA 98104, USA
    J Bacteriol 185:6262-8. 2003
    The tprK gene of Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, belongs to a 12-member gene family and encodes a protein with a predicted cleavable signal sequence and predicted transmembrane domains...
  28. ncbi Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
    E Lien
    Maxwell Finland Laboratory for Infectious Diseases, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 274:33419-25. 1999
    ..We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or ..
  29. ncbi Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes
    Deborah Watson-Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 186:948-57. 2002
    ..were compared among women treated for high-titer (n=133; rapid plasma reagin [RPR] titer > or = 1:8 and Treponema pallidum hemagglutination assay [TPHA]/fluorescent treponemal antibody [FTA] positive) and low-titer (n=249; RPR ..
  30. doi Etiology and determinants of sexually transmitted infections in Karnataka state, south India
    Marissa Becker
    Department of Medicine, University of Manitoba, 771 McDermot Avenue, Winnipeg, Manitoba, Canada
    Sex Transm Dis 37:159-64. 2010
    ..We undertook this study to better understand the etiology of STIs in adults in south India and to inform STI management guidelines...
  31. pmc Detection of Treponema pallidum subsp. pallidum from skin lesions, serum, and cerebrospinal fluid in an infant with congenital syphilis after clindamycin treatment of the mother during pregnancy
    Vladana Woznicová
    Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic
    J Clin Microbiol 45:659-61. 2007
    ..Using PCR detection of tmpC (TP0319) and DNA sequencing of the genes TP0136 and TP0548, DNA sequences identical to Treponema pallidum subsp. pallidum strain SS14 were detected in the infant's skin lesions, serum, and cerebrospinal fluid.
  32. pmc Clinical value of Treponema pallidum real-time PCR for diagnosis of syphilis
    R Heymans
    Public Health Laboratory, Amsterdam Public Health Service, Amsterdam, The Netherlands
    J Clin Microbiol 48:497-502. 2010
    ..In the present study, therefore, we examined the additional clinical value of a Treponema pallidum real-time TaqMan PCR for the detection of primary and secondary syphilis. The additional value of the T...
  33. ncbi Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone
    Y H Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8884, USA
    Nat Struct Biol 6:628-33. 1999
    ..of recombinant TroA, a zinc-binding protein component of an ATP-binding cassette transport system in Treponema pallidum, was determined at a resolution of 1.8 A...
  34. pmc Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments
    Adriana R Cruz
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    PLoS Negl Trop Dis 6:e1717. 2012
    The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation.
  35. ncbi Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene family
    L V Stamm
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    FEMS Microbiol Lett 169:155-63. 1998
    TnphoA mutagenesis was used to identify genes encoding exported proteins in a genomic DNA library of Treponema pallidum, the syphilis agent...
  36. pmc Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, WA, USA
    FEMS Immunol Med Microbiol 51:289-301. 2007
    In Treponema pallidum, homopolymeric guanosine repeats of varying length are present upstream of both Subfamily I (tprC, D, F and I) and II (tprE, G and J) tpr genes, a group of potential virulence factors, immediately upstream of the +1 ..
  37. ncbi From microbial genome sequence to applications
    G M Weinstock
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, 77030, USA
    Res Microbiol 151:151-8. 2000
    ..These areas for technological development should be stimulated by the potential for converting genomic sequence information into applications...
  38. pmc Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity
    D R Akins
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235
    Infect Immun 61:1202-10. 1993
    A murine monoclonal antibody specific for a 17-kDa major membrane immunogen of Treponema pallidum was used to select recombinant Escherichia coli clones expressing the molecule from a T. pallidum genomic library...
  39. pmc CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis
    Brandon T Leader
    Department of Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    Infect Immun 75:3021-6. 2007
    The clearance of Treponema pallidum subsp. pallidum from early syphilis lesions involves infiltration of a large number of mononuclear cells and is characteristic of a cell-mediated immune response...
  40. ncbi On-site rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinics
    Rachel N Bronzan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Sex Transm Dis 34:S55-60. 2007
    ..syphilis screening strategies at rural clinics: on-site rapid plasma reagin (RPR), on-site treponemal immunochromatographic strip (ICS) test, and the standard practice offsite RPR with Treponema pallidum hemagglutination assay (RPR/TPHA).
  41. pmc Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Immunol 184:3822-9. 2010
    ..In Treponema pallidum (T...
  42. ncbi Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity
    Eileen S Sun
    Department of Pathobiology, University of Washington, Box 357185, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Microbes Infect 6:725-37. 2004
    A 12-membered Treponema pallidum repeat (Tpr) protein family has been identified in T. pallidum subsp. pallidum, the causative agent of syphilis...
  43. doi Sequencing-based molecular typing of treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 strain
    Magdalena Flasarová
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
    Acta Derm Venereol 92:669-74. 2012
    ..The variants of arp and tpr genes appear to combine independently with sequence variants of TP0136, TP0548 and 23S rRNA genes...
  44. pmc Molecular typing of Treponema pallidum: a systematic review and meta-analysis
    Rui Rui Peng
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China
    PLoS Negl Trop Dis 5:e1273. 2011
    ..This study aimed to review original research on molecular typing of Treponema pallidum (T...
  45. doi Comparative analysis of immunohistochemistry, polymerase chain reaction and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis
    H Muller
    Department of Dermatology, Medical University Innsbruck, Innsbruck, Austria
    Br J Dermatol 165:50-60. 2011
    ..Depending on the disease stage, direct detection of Treponema pallidum in mucocutaneous lesions of syphilis may be difficult and histopathological findings are not always ..
  46. doi The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis
    H Young
    Scottish Bacterial Sexually Transmitted Infections Reference Laboratory, Department of Medical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, UK
    Sex Transm Infect 85:19-23. 2009
    ..To determine the sensitivity and specificity of the Architect Syphilis Chemiluminescence Assay (CLIA): a new highly automated screening test for syphilis...
  47. ncbi Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidum
    Hsi Liu
    National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Microbiol 56:715-21. 2007
    The acidic repeat protein (arp) genes from three subspecies of the treponeme Treponema pallidum (T. pallidum subsp. pallidum, Nichols strain; T. pallidum subsp. pertenue, CDC-1 and CDC-2 strains; and T. pallidum subsp...
  48. ncbi [Molecular detection and subtyping of Treponema pallidum subsp. pallidum in clinical specimens]
    M Flasarová
    Biologický ustav, LF MU, Brno
    Epidemiol Mikrobiol Imunol 55:105-11. 2006
    ..the tmpC gene (TP0319, encoding putative membrane lipoprotein) was used for detection of chromosomal DNA of Treponema pallidum subsp. pallidum in clinical specimens...
  49. pmc TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Mol Microbiol 72:1087-99. 2009
    Transcriptional regulation in Treponema pallidum ssp. pallidum is poorly understood, primarily because this organism cannot be cultivated in vitro or genetically manipulated...
  50. doi Serologic testing for syphilis in the United States: a cost-effectiveness analysis of two screening algorithms
    Kwame Owusu-Edusei
    Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road MS E 80, Atlanta, GA 30333, USA
    Sex Transm Dis 38:1-7. 2011
    ..We compared the economic and health outcomes of this new algorithm with the standard algorithm from the perspective of the United States health system...
  51. pmc Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography
    Jun Liu
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2 228, Houston, TX 77030, USA
    J Mol Biol 403:546-61. 2010
    High-resolution cryo electron tomography (cryo-ET) was utilized to visualize Treponema pallidum, the causative agent of syphilis, at the molecular level...
  52. pmc Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the Rakai District, Uganda
    T R Suntoke
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Sex Transm Infect 85:97-101. 2009
    ..predominant sexually transmitted aetiological agents of genital ulcer disease (GUD) (Haemophilus ducreyi, Treponema pallidum and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)) and to assess the use of real-time PCR ..
  53. ncbi A mgl-like operon in Treponema pallidum, the syphilis spirochete
    S F Porcella
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Gene 177:115-21. 1996
    A 38-kDa lipoprotein of Treponema pallidum subsp. pallidum (T. pallidum), the syphilis spirochete, previously was identified as a putative homolog of E. coli MglB [Becker et al. (1994) Infect. Immun. 62, 1381-1391]...
  54. doi Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum
    Petra Matejková
    Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
    J Med Microbiol 58:832-6. 2009
    ..The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic...
  55. ncbi Syphilis. Serology
    H Young
    Scottish Neisseria gonorrhoeae Reference Laboratory, Edinburgh University Medical School, Scotland
    Dermatol Clin 16:691-8. 1998
    ..The role of the laboratory in aiding a diagnosis of neurosyphilis and congenital infection is discussed briefly, as is the current status of newer technologies, such as PCR and immunoblotting...
  56. doi Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China
    Irene E Martin
    Division of Pathogenic Neisseria, Syphilis Diagnostics, Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Clin Infect Dis 49:515-21. 2009
    ..This study focuses on implementing polymerase chain reaction (PCR) diagnostic tests for syphilis and for detection of molecular subtypes and macrolide resistance among strains causing primary syphilis in the city of Shanghai, China...
  57. pmc Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis
    Adriana R Cruz
    Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, Cali, Colombia
    PLoS Negl Trop Dis 4:e690. 2010
    Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp)...
  58. ncbi Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidum
    A G Koek
    Amsterdam Municipal Health Laboratory and Department of Infectious Diseases, Amsterdam, The Netherlands
    Clin Microbiol Infect 12:1233-6. 2006
    A real-time PCR assay with a Taqman probe was developed that targeted the polA gene of Treponema pallidum. The test was validated using an analytical panel (n = 140) and a clinical panel of genital samples (n = 112) from patients ..
  59. ncbi Detection of Treponema pallidum sp pallidum DNA in latent syphilis
    R Castro
    Unidade de Doenças Sexualmente Transmitidas, IHMT, UNL, Lisboa, Portugal
    Int J STD AIDS 18:842-5. 2007
    In this study, polymerase chain reaction (PCR) techniques were used to detect Treponema pallidum DNA in samples from patients with latent syphilis. Sixty-nine patients with latent syphilis and 18 with treated syphilis were included...
  60. pmc Global challenge of antibiotic-resistant Treponema pallidum
    LOLA V STAMM
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 54:583-9. 2010
    ..Macrolide-resistant strains of Treponema pallidum are now prevalent in several developed countries. An understanding of the genetic basis of T...
  61. pmc Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model
    Cecilia A Morgan
    Departments of Pathobiology, University of Washington, Seattle 98195, USA
    Infect Immun 70:6811-6. 2002
    When used as an immunogen, Treponema pallidum repeat protein K (TprK) has been shown to attenuate syphilitic lesions upon homologous intradermal challenge in the rabbit model...
  62. pmc Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum
    Wesley C Van Voorhis
    Departments of Medicine and Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Clin Microbiol 41:3668-74. 2003
    Syphilis serodiagnosis relies on a combination of nonspecific screening tests (antilipoidal antibodies) and Treponema pallidum-specific tests (anti-T. pallidum antibodies). We studied a group of six recombinant T...
  63. ncbi Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples
    A Gayet-Ageron
    HIV Care Unit, Division of Infectious Diseases, Geneva s University Hospitals and School of Medicine, Geneva, Switzerland
    Sex Transm Infect 85:264-9. 2009
    To investigate the contribution of a real-time PCR assay for the detection of Treponema pallidum in various biological specimens with the secondary objective of comparing its value according to HIV status.
  64. pmc Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing
    David E Leslie
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Clin Microbiol 45:93-6. 2007
    ..A TaqMan real-time PCR assay targeting the polA gene of Treponema pallidum (TpPCR) was developed. The analytical sensitivity of the assay was estimated to be 1...
  65. pmc Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K
    Cecilia A Morgan
    Department of Pathobiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Infect Immun 71:5605-12. 2003
    ..It has been shown that the Treponema pallidum repeat protein K (TprK) differs in seven discrete variable (V) regions in isolates and that the antibody ..
  66. pmc Syphilis at the crossroad of phylogenetics and paleopathology
    Fernando Lucas de Melo
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 4:e575. 2010
    ..Then, we selected the oldest ones to calibrate the time of the most recent common ancestor of Treponema pallidum subsp. pallidum, T. pallidum subsp. endemicum and T. pallidum subsp...
  67. pmc Molecular typing of treponema pallidum clinical strains from Lisbon, Portugal
    C Florindo
    Department of Infectious Diseases, Instituto Nacional de Saude Dr Ricardo Jorge, Av Padre Cruz, Lisbon 1649 016, Portugal
    J Clin Microbiol 46:3802-3. 2008
    A molecular system was used to subtype Portuguese Treponema pallidum clinical strains isolated from both skin lesions and blood. The study with this system constitutes the first typing study in a European country. Three T...
  68. ncbi Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture
    Sheila A Lukehart
    Department of Medicine, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    Sex Transm Dis 35:2-7. 2008
  69. pmc Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs
    Irene E Martin
    Division of Pathogenic Neisseria, Syphilis Diagnostics, and Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    J Clin Microbiol 47:1668-73. 2009
    Although detection of Treponema pallidum DNA in whole-blood specimens of syphilis patients has been reported, it is uncertain at what stage of the disease such specimens are most suitable for the molecular diagnosis of syphilis...
  70. pmc Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCR
    Juan C Salazar
    Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Infect Immun 75:2954-8. 2007
    ..We used real-time quantitative PCR to measure Treponema pallidum DNA levels in rabbits infected intratesticularly with the prototype Nichols strain...
  71. ncbi Alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infection
    C M Marra
    Department of Medicine, University of Washington, Seattle
    J Infect Dis 165:1020-5. 1992
    ..After intradermal inoculation with Treponema pallidum, 2 SIV-infected monkeys had persistent ulcerative primary lesions and 1 developed secondary syphilis...
  72. ncbi Use of the polymerase chain reaction to detect DNA sequences specific to pathogenic treponemes in cerebrospinal fluid
    P E Hay
    Clinical Research Centre, Harrow, Middlesex, London
    FEMS Microbiol Lett 56:233-8. 1990
    The polymerase chain reaction was used to detect Treponema pallidum in specimens of cerebrospinal fluid (CSF), as a means of diagnosing syphilis...
  73. ncbi Detection of the 47-kilodalton membrane immunogen gene of Treponema pallidum in various tissue sources of patients with syphilis
    Alexander Vasilevich Kouznetsov
    Laboratory of Immune Pathogenesis and Serology, Department of Dermatology and Allergology, Ludwig Maximilians University of Munich, 80337 Munich, Germany
    Diagn Microbiol Infect Dis 51:143-5. 2005
    Polymerase chain reaction (PCR) was used to detect the 47-kDa immunogen gene of Treponema pallidum in peripheral blood mononuclear cells (PBMCs), skin lesions, and serum, but less consistently in purified granulocytes or ejaculates of ..
  74. pmc Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar
    Kathleen Van Damme
    Department of Medicine, Division of Infectious Diseases, University of North Carolina, Madagascar UNC Mad, Antananarivo, Madagascar
    Sex Transm Dis 36:775-6. 2009
    b>Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland...
  75. pmc Superoxide reductase from the syphilis spirochete Treponema pallidum: crystallization and structure determination using soft X-rays
    Teresa Santos-Silva
    REQUIMTE Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:967-70. 2005
    ..The oxidized form of Treponema pallidum superoxide reductase was crystallized in the presence of polyethylene glycol and magnesium chloride...
  76. ncbi Redox-dependent structural changes in the superoxide reductase from Desulfoarculus baarsii and Treponema pallidum: a FTIR study
    Catherine Berthomieu
    CEA Cadarache, DSV DEVM, Laboratoire de Bioenergetique Cellulaire, UMR 163 CNRS CEA, Univ Méditerranée CEA 1000, Bât 156, F 13108 Saint Paul lez Durance, Cedex, France
    Biochemistry 41:10360-8. 2002
    ..structural changes at the active site of the superoxide reductase (SOR) from Desulfoarculus baarsii and Treponema pallidum have been monitored by means of FTIR difference spectroscopy coupled to electrochemistry...
  77. pmc Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum
    Derek Parsonage
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 107:6240-5. 2010
    Little is known about the mechanisms by which Treponema pallidum (Tp), the causative agent of syphilis, copes with oxidative stress as it establishes persistent infection within its obligate human host...
  78. pmc Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia
    J Guarner
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 6:487-92. 2000
    ..Testing umbilical cords by using immunohistochemistry is a research tool that can establish the frequency of funisitis due to Treponema pallidum infection.
  79. ncbi Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction
    Chao Chang Wu
    Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Am Acad Dermatol 55:S11-5. 2006
    ..No spirochete could be found in the skin sections staining with Warthin-Starry stain. Using nested polymerase chain reaction, treponemal genomic DNA fragments encoding DNA polymerase I were detected...
  80. pmc Treponema pallidum macrolide resistance in BC
    Muhammad G Morshed
    CMAJ 174:349. 2006
  81. ncbi Production of tumor necrosis factor alpha by Treponema pallidum, Borrelia burgdorferi s.l., and Leptospira interrogans in isolated rat Kupffer cells
    Antonella Marangoni
    Sezione di Microbiologia DMCSS, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    FEMS Immunol Med Microbiol 40:187-91. 2004
    Stimulation of isolated rat Kupffer cells by viable Leptospira interrogans, Treponema pallidum and Borrelia garinii elicited cellular responses resulting in the release of different tumor necrosis factor alpha (TNF-alpha) levels, ..
  82. pmc Genital ulcer disease in men in Durban, South Africa
    N O'Farrell
    City Health STD Department, King Edward VIII Hospital, Durban, South Africa
    Genitourin Med 67:327-30. 1991
    ..To study the microbial aetiology of genital ulcer disease (GUD) in men...
  83. ncbi The first crystal structure of class III superoxide reductase from Treponema pallidum
    Teresa Santos-Silva
    REQUIMTE CQFB, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516, Caparica, Portugal
    J Biol Inorg Chem 11:548-58. 2006
    ..The crystal structure of Treponema pallidum (Tp) SOR was determined using soft X-rays and synchrotron radiation...
  84. ncbi Detection and discrimination of herpes simplex viruses, Haemophilus ducreyi, Treponema pallidum, and Calymmatobacterium (Klebsiella) granulomatis from genital ulcers
    Ian M Mackay
    Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Queensland, Australia
    Clin Infect Dis 42:1431-8. 2006
    ..This collaborative project was undertaken to address the need for a rapid, economical, and sensitive approach to the detection and diagnosis of GUD using noninvasive techniques to sample genital ulcers...
  85. pmc Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1)
    D R Blanco
    Department of Microbiology and Immunology, School of Medicine, University of California at Los Angeles 90024, USA
    J Bacteriol 177:3556-62. 1995
    We have recently reported the isolation and purification of the Treponema pallidum outer membrane and the identification of its rare protein constituents, including a 31-kDa protein markedly enriched in the outer membrane preparation (D.R...
  86. doi Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypes
    Irene E Martin
    Division of Pathogenic Neisseria, Syphilis Diagnostics, and Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Sex Transm Dis 37:544-8. 2010
    ..chain reaction diagnostic tests for syphilis, identifies macrolide resistance, and uses a molecular typing system to characterize Treponema pallidum clinical strains causing syphilis in Alberta and Northwest Territories, Canada.
  87. ncbi Identification and sequences of the Treponema pallidum mglA and mglC genes
    L V Stamm
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    DNA Seq 6:293-8. 1996
    b>Treponema pallidum, the agent of syphilis, cannot be continuously cultivated in vitro. To identify treponemal genes encoding exported proteins, we performed TnphoA mutagenesis of a T. pallidum genomic DNA library in Escherichia coli...
  88. ncbi Pulse radiolysis studies on superoxide reductase from Treponema pallidum
    V Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université Joseph Fourier, Cedex 9, France
    FEBS Lett 497:171-3. 2001
    ..The reaction of the enzyme from Treponema pallidum with superoxide was studied by pulse radiolysis methods...
  89. ncbi Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue
    C E Stebeck
    Department of Medicine, University of Washington, Seattle 98195, USA
    FEMS Microbiol Lett 154:303-10. 1997
    To identify potential opsonic targets of Treponema pallidum subsp. pallidum, a treponemal genomic expression library was constructed and differentially screened with opsonic and non-opsonic T. pallidum antisera...
  90. pmc Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete
    D V Shevchenko
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Infect Immun 65:4179-89. 1997
    ..5 kDa, which had been identified previously in OM fractions from Treponema pallidum (J. D. Radolf et al., Infect. Immun. 63:4244-4252, 1995)...
  91. ncbi Prevalence of circulating Treponema pallidum DNA and RNA in blood donors with confirmed-positive syphilis tests
    Sharyn L Orton
    American Red Cross Holland Laboratory, Rockville, Maryland, USA
    Transfusion 42:94-9. 2002
    ..DNA PCR and RNA RT-PCR were applied to assess the presence of Treponema pallidum DNA or RNA in blood donors with confirmed-positive results in STS.
  92. pmc Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, Portugal
    R Castro
    Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal
    J Clin Microbiol 47:2510-2. 2009
    The objectives of this study were to evaluate the reproducibility of a molecular method for the subtyping of Treponema pallidum subsp. pallidum and to discriminate strains of this microorganism from strains from patients with syphilis...
  93. ncbi Immunization with Treponema pallidum outer membrane vesicles induces high-titer complement-dependent treponemicidal activity and aggregation of T. pallidum rare outer membrane proteins (TROMPs)
    D R Blanco
    Department of Microbiology, Immunology, and Molecular Genetics, School of Medicine, University of California, Los Angeles 90024, USA
    J Immunol 163:2741-6. 1999
    ..purpose of this study was to determine whether immunization with purified outer membrane vesicles (OMV) from Treponema pallidum (T.p. ) could elicit Abs capable of killing this organism...
  94. ncbi Comparison of a Treponema pallidum IgM immunoblot with a 19S fluorescent treponemal antibody absorption test for the diagnosis of congenital syphilis
    Martina Herremans
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Laboratory for Infectious Diseases and Perinatal Screening, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Diagn Microbiol Infect Dis 59:61-6. 2007
    We compared an in-house Treponema pallidum IgM immunoblot (IB) with a 19S fluorescent treponemal antibody absorption (IgM) test during routine use for the diagnosis of congenital syphilis (CS) in a national reference laboratory in a ..
  95. ncbi Contribution of neelaredoxin to oxygen tolerance by Treponema pallidum
    Karsten R O Hazlett
    Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Methods Enzymol 353:140-56. 2002
  96. ncbi The genome of Treponema pallidum: new light on the agent of syphilis
    G M Weinstock
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston 77030, USA
    FEMS Microbiol Rev 22:323-32. 1998
    b>Treponema pallidum subsp, pallidum, the causative agent of the sexually transmitted disease syphilis, is a fastidious, microaerophilic obligate parasite of humans...
  97. pmc On the origin of the treponematoses: a phylogenetic approach
    Kristin N Harper
    Department of Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 2:e148. 2008
    ..Since the first recorded epidemic of syphilis in 1495, controversy has surrounded the origins of the bacterium Treponema pallidum subsp...
  98. pmc Polymerase chain reaction and synthetic DNA probes: a means of distinguishing the causative agents of syphilis and yaws?
    G T Noordhoek
    Laboratory of Bacteriology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Infect Immun 58:2011-3. 1990
    Synthetic DNA probes specific for either the tpf-1 gene of Treponema pallidum subsp. pallidum Nichols or the tyf-1 gene of Treponema pallidum subsp...
  99. ncbi Treponema pallidum subspecies pallidum (Nichols) and Treponema pallidum subspecies pertenue (CDC 2575) differ in at least one nucleotide: comparison of two homologous antigens
    G T Noordhoek
    Laboratory for Bacteriology, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
    Microb Pathog 6:29-42. 1989
    In an attempt to identify antigenic differences between Treponema pallidum subsp. pallidum (T. pallidum) and Treponema pallidum subsp. pertenue (T. pertenue) a gene bank of T. pertenue was constructed in lambda vector EMBL3...
  100. ncbi The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
    Ranjit K Deka
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:8072-81. 2006
    b>Treponema pallidum, the bacterial agent of syphilis, cannot be cultivated in vitro. This constraint has severely impeded the study of the membrane biology of this complex human pathogen...
  101. pmc A new attempt to distinguish serologically the subspecies of Treponema pallidum causing syphilis and yaws
    G T Noordhoek
    Laboratory of Bacteriology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    J Clin Microbiol 28:1600-7. 1990
    In an effort to serologically differentiate syphilis from yaws, 69 monoclonal antibody species raised against Treponema pallidum subsp. pallidum were tested by immunoblotting for their reactivity with Treponema pallidum subsp. pertenue...

Research Grants68

  1. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..and treatment of rare diseases, Syphilis is a chronic, multisystemic disease caused by the spirochete, Treponema pallidum subspecies pallidum (T. pallidum). The spirochete is acquired by sexual contact and is prevalent worldwide...
  2. Crane - CheA and its Complexes
    Brian R Crane; Fiscal Year: 2010
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish infection...
  3. Crane - CheA and its Complexes
    BRIAN CRANE; Fiscal Year: 2009
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish infection...
  4. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2000
    ..the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the development ..
  5. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
    ..the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the development ..
  6. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 1999
    ..the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the development ..
  7. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2007
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  8. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2005
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  9. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2004
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  10. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  11. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
  12. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..The application of genetic advancements and the availability of genomic sequences of Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp, are proving a wealth of new information...
  13. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
  14. GENE ANALYSIS OF SPIROCHETE PERIPLASMIC FLAGELLA
    NYLES CHARON; Fiscal Year: 1999
    ..These spirochetes have PFs very similar to those found in Treponema pallidum, the causative agent for syphilis. T...
  15. PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUM
    Steven Norris; Fiscal Year: 1990
    b>Treponema pallidum subsp. pallidum and related organisms are helically- shaped bacteria which cause venereal syphilis, endemic syphilis, yaws and pinta in humans...
  16. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
  17. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2006
    ..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
  18. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 1993
    ..abstract): Spirochetes are a unique and diverse group of helical-shaped bacteria that include the pathogens Treponema pallidum (syphilis) and Borrelia burgdorferi (Lyme disease)...
  19. GENETICS OF TREPONEMA PALLIDUM PATHOGENICITY
    Michael Lovett; Fiscal Year: 1991
    ..There has been recent progress in understanding the molecular basis of two key aspects of the immunobiology of Treponema pallidum, the antigenic inertness of its surface, and its resistance to killing by immune mechanisms...
  20. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    George W Ordal; Fiscal Year: 2010
    ..Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp., and Treponema pallidum have homologues to CheC, CheD, and CheV, genes first identified and then characterized in B. subtilis.
  21. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    GEORGE ORDAL; Fiscal Year: 2009
    ..Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp., and Treponema pallidum have homologues to CheC, CheD, and CheV, genes first identified and then characterized in B. subtilis.
  22. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 1999
    ..However, the recent publication of the genomic sequences for Borrelia burgdorferi and Treponema pallidum, and a newly initiated project for sequencing the Treponema denticola genome, provide a wealth of new ..
  23. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 2000
    ..However, the recent publication of the genomic sequences for Borrelia burgdorferi and Treponema pallidum, and a newly initiated project for sequencing the Treponema denticola genome, provide a wealth of new ..
  24. IMMUNOGENS OF T PALLIDUM: IDENTIFICATION AND FUNCTION
    Sheila Lukehart; Fiscal Year: 1990
    ..Although a number of Treponema pallidum antigens have been identified and characterized in terms of antibody reactivity, little is known about the ..
  25. A Novel Approach to the Development of a Syphilis Vaccine Using Rabbit Monoclonal
    James Miller; Fiscal Year: 2009
    ..The focus of this proposal is the isolation of rabbit monoclonal antibodies directed against Treponema pallidum surface antigens that are targets of treponemicidal activity...
  26. NEWLY RECOGNIZED T PALLIDUM-RELATED ORAL SPIROCHETE
    GEORGE RIVIERE; Fiscal Year: 1993
    ..display significant homology with antigens previously thought to be unique to the well-recognized pathogen, Treponema pallidum. T. pallidum monoclonal antibodies (mAbs) used to identify these spirochetes react with subspecies of T...
  27. SYPHILIS IMMUNITY
    Stewart Sell; Fiscal Year: 1980
    ..The immune response to the infecting organisms, Treponema pallidum is poorly understood...
  28. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2002
    ..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
  29. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2003
    ..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
  30. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2001
    ..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
  31. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2000
    ..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
  32. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2004
    ..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
  33. IMMUNE MECHANISMS IN EXPERIMENTAL SYPHILIS
    Michael Lovett; Fiscal Year: 1999
    ..experimental syphilis has been limited by the fact that the rare outer membrane spanning proteins (TROMP) of Treponema pallidum had not been defined. This proposal is based on isolation of the T...
  34. Structure and Function of Treponema pallidum Lipoproteins
    MICHAEL NORGARD; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Syphilis, caused by the spirochetal bacterium Treponema pallidum, continues to play prominently as a sexually transmitted disease...
  35. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Syphilis, caused by the spirochetal bacterium Treponema pallidum, continues to play prominently as a sexually transmitted disease...
  36. T PALLIDUM ANTIGENS FROM RECOMBINANT DNA
    MICHAEL NORGARD; Fiscal Year: 1980
    ..research proposal is to utilize recombinant DNA technology to identify and isolate the major immunogens of Treponema pallidum, and to test these immunogens as possible effective vaccines against syphilitic infection...
  37. PATHOGENIC MECHANISMS IN LYME BORRELIOSIS
    Michael Lovett; Fiscal Year: 1992
    ..Our finding that Bb, like Treponema pallidum, can invade endothelial intercellular junctions represents a potential dissemination mechanism; we will ..
  38. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 1999
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema denticola)...
  39. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2000
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema denticola)...
  40. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2002
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema denticola)...
  41. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2001
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema denticola)...
  42. PATHOGENIC MECHANISMS IN LYME BORRELIOSIS
    Michael Lovett; Fiscal Year: 1993
    ..Our finding that Bb, like Treponema pallidum, can invade endothelial intercellular junctions represents a potential dissemination mechanism; we will ..
  43. PATHOGENIC MECHANISMS IN LYME BORRELIOSIS
    Michael Lovett; Fiscal Year: 1991
    ..Our finding that Bb, like Treponema pallidum, can invade endothelial intercellular junctions represents a potential dissemination mechanism; we will ..
  44. PATHOGENIC MECHANISMS IN LYME BORRELIOSIS
    Michael Lovett; Fiscal Year: 1990
    ..Our finding that Bb, like Treponema pallidum, can invade endothelial intercellular junctions represents a potential dissemination mechanism; we will ..
  45. FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Timothy Palzkill; Fiscal Year: 2005
    ..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
  46. FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Timothy Palzkill; Fiscal Year: 2006
    ..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
  47. FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Timothy Palzkill; Fiscal Year: 2004
    ..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
  48. FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Timothy Palzkill; Fiscal Year: 2003
    ..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
  49. FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Timothy Palzkill; Fiscal Year: 2002
    ..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
  50. GENETIC ORGANIZATION OF TREPONEMA PALLIDUM
    Steven Norris; Fiscal Year: 1992
    ..of this project is to provide a comprehensive view of the genetic organization and metabolic capabilities of Treponema pallidum and to correlate this information with the unique physiology of this bacterium and its pathogenesis in ..
  51. PATHOGENESIS AND THERAPY OF EXPERIMENTAL NEUROSYPHILIS
    Christina Marra; Fiscal Year: 1992
    ..b>Treponema pallidum invades the central nervous system (CNS) in the first weeks of infection, as demonstrated by CSF pleocytosis,..
  52. MOLECULAR ANALYSIS OF T PALLIDUM MEMBRANE IMMUNOGENS
    MICHAEL NORGARD; Fiscal Year: 1991
    Recently it was discovered that several of the major integral membrane immunogens of Treponema pallidum are lipoproteins...
  53. MOLECULAR ANALYSIS OF T PALLIDUM MEMBRANE IMMUNOGENS
    MICHAEL NORGARD; Fiscal Year: 1992
    Recently it was discovered that several of the major integral membrane immunogens of Treponema pallidum are lipoproteins...
  54. MOLECULAR ANALYSIS OF T PALLIDUM MEMBRANE IMMUNOGENS
    MICHAEL NORGARD; Fiscal Year: 1993
    Recently it was discovered that several of the major integral membrane immunogens of Treponema pallidum are lipoproteins...
  55. GENETICS OF T PALLIDUM PATHOGENESIS
    MICHAEL NORGARD; Fiscal Year: 1990
    Recently it was discovered that several of the major integral membrane immunogens of Treponema pallidum are lipoproteins...
  56. Multiple Antigen Point-of-Care Device for Improved Syphilis Diagnosis
    Michael J Lochhead; Fiscal Year: 2010
    ..It is a sexually transmitted and congenital disease caused by the bacterium Treponema pallidum. When properly diagnosed, it is readily treatable with relatively inexpensive antimicrobial therapies...
  57. SEQUENCING OF THE HAEMOPHILUS DUCREYI GENOME
    Robert Munson; Fiscal Year: 1999
    ..a integrated data base with detailed annotation of sequences from sexually transmitted pathogens including Treponema pallidum, Neisseria gonorrhoeae and Chlamydia trachomatis. Genome sequences for these organisms are near completion...
  58. WHOLE GENOME PHAGE DISPLAY OF T PALLIDUM GENES
    Timothy Palzkill; Fiscal Year: 2001
    ..Phage display libraries that include all of the open reading frames (ORFs) of Treponema pallidum will be constructed. T. pallidum is the causative agent of syphilis...
  59. WHOLE GENOME PHAGE DISPLAY OF T PALLIDUM GENES
    Timothy Palzkill; Fiscal Year: 2000
    ..Phage display libraries that include all of the open reading frames (ORFs) of Treponema pallidum will be constructed. T. pallidum is the causative agent of syphilis...