Genomes and Genes
Summary: The causative agent of venereal and non-venereal syphilis as well as yaws.
Publications256 found, 100 shown here
- Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodiesNeuza Satomi Sato
Seção de Sorologia, Instituto Adolfo Lutz, Sao Paulo, SP, Brasil
Rev Inst Med Trop Sao Paulo 45:319-22. 2003..for detecting specific antibodies to Treponema pallidum was evaluated against serum samples from patients with clinical, epidemiological and serological diagnosis ..
- TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane proteinDaniel C Desrosiers
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
Mol Microbiol 80:1496-515. 2011Definitive identification of Treponema pallidum rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in T...
- Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequenceDarina Čejková
Department of Biology, Masaryk University, Brno, Czech Republic
PLoS Negl Trop Dis 6:e1471. 2012The yaws treponemes, Treponema pallidum ssp. pertenue (TPE) strains, are closely related to syphilis causing strains of Treponema pallidum ssp. pallidum (TPA)...
- Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilisLorenzo Giacani
Department of Medicine, Box 359779, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 2499, USA
Infect Immun 75:104-12. 2007Transcriptional analysis of the tpr genes in Treponema pallidum subsp. pallidum (referred to here as simply T...
- Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yawsDavid Smajs
Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
Infect Genet Evol 12:191-202. 2012Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively...
- Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomesRekha Seshadri
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Proc Natl Acad Sci U S A 101:5646-51. 2004..denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome ..
- Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arraysPetra Matejková
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
BMC Microbiol 8:76. 2008Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood...
- Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidumDavid L Cox
Division of STD Prevention, Laboratory Reference and Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Infect Immun 78:5178-94. 2010b>Treponema pallidum reacts poorly with the antibodies present in rabbit and human syphilitic sera, a property attributed to the paucity of proteins in its outer membrane...
- Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strainLorenzo Giacani
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98195, USA
J Bacteriol 192:2645-6. 2010In syphilis research, the Nichols strain of Treponema pallidum, isolated in 1912, has been the most widely studied. Recently, important differences among T...
- Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regionsLenka Mikalová
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
PLoS ONE 5:e15713. 2010..p. pallidum and T. p. pertenue strains. These regions of sequence divergence could be used for the molecular detection and discrimination of syphilis and yaws strains...
- Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infectionDavid Smajs
Human Genome Sequencing Center, University of Texas Houston Medical School, Houston, Texas, USA
J Bacteriol 187:1866-74. 2005RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T...
- Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi AMichal Strouhal
Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
Infect Immun 75:5859-66. 2007..genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp...
- Treponema infection associated with genital ulceration in wild baboonsS Knauf
Justus Liebig University, Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Frankfurterstrasse 106, 35393 Giessen, Germany
Vet Pathol 49:292-303. 2012The authors describe genital alterations and detailed histologic findings in baboons naturally infected with Treponema pallidum. The disease causes moderate to severe genital ulcerations in a population of olive baboons (Papio hamadryas ..
- Preliminary evaluation of an immunochromatographic strip test for specific Treponema pallidum antibodiesPinar Zarakolu
Section of Infectious Diseases, Department of Medicine, School of Medicine, Hacettepe University, Ankara, Turkey
J Clin Microbiol 40:3064-5. 2002We evaluated a prototype immunochromatographic strip (ICS) test for qualitative detection of Treponema pallidum antibodies in 353 sera from 157 patients...
- Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st centuryArlene C Sena
Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
Clin Infect Dis 51:700-8. 2010The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests...
- Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidumBrandon T Leader
Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
Infect Immun 71:6054-7. 2003Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection...
- Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus TreponemaR R Gray
Department of Anthropology, University of Florida, USA
Mol Biol Evol 23:2220-33. 2006We investigated the evolution of 6 genes from the Treponema pallidum repeat (tpr) gene family, which encode potential virulence factors and are assumed to have evolved through gene duplication and gene conversion events...
- Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogenLorenzo Giacani
Department of Medicine, University of Washington, Seattle, WA, USA
PLoS Negl Trop Dis 6:e1698. 2012In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical...
- TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structureArvind Anand
Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
J Bacteriol 194:2321-33. 2012Identification of Treponema pallidum rare outer membrane proteins (OMPs) has been a longstanding objective of syphilis researchers...
- A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectinMary Beth Brinkman
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Infect Immun 76:1848-57. 2008The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp...
- Syphilis: reemergence of an old adversaryJennifer R Chao
Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
Ophthalmology 113:2074-9. 2006..To describe the clinical findings in 4 patients with ocular syphilis and to provide a review of the recent rise in syphilis cases in the United States, along with a brief description of current diagnosis and treatment guidelines...
- Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92C E Cameron
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Infect Dis 181:1401-13. 2000By means of a differential screening technique, a 92-kDa antigen, designated Tp92, was identified from Treponema pallidum subspecies pallidum...
- Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilisChristina M Marra
Departments of Neurology, University of Washington School of Medicine, Seattle, Washington 98104 2499, USA
J Infect Dis 202:1380-8. 2010..Strain typing is a tool for determining the diversity and epidemiology of infections...
- Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune responseA Centurion-Lara
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Exp Med 189:647-56. 1999..pallidum. This gene family is hypothesized to be central to pathogenesis and immunity during syphilis infection...
- Molecular differentiation of Treponema pallidum subspeciesArturo Centurion-Lara
Department of Medicine, University of Washington, Seattle, 98195, USA
J Clin Microbiol 44:3377-80. 2006b>Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test...
- Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strainsC E Cameron
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Infect Immun 67:3168-70. 1999Previous investigations have demonstrated that immunization with Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase significantly protects rabbits from subsequent treponeme challenge...
- Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcersK A Orle
Roche Molecular Systems, Alameda, California 94501, USA
J Clin Microbiol 34:49-54. 1996..detection was devised for the simultaneous amplification of DNA targets from Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV) types 1 and 2...
- Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial productsE Lien
Maxwell Finland Laboratory for Infectious Diseases, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 274:33419-25. 1999..We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or ..
- Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolatesRebecca E LaFond
Departments of Pathobiology, University of Washington, Seattle, WA 98104, USA
J Bacteriol 185:6262-8. 2003The tprK gene of Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, belongs to a 12-member gene family and encodes a protein with a predicted cleavable signal sequence and predicted transmembrane domains...
- Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomesDeborah Watson-Jones
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 186:948-57. 2002..were compared among women treated for high-titer (n=133; rapid plasma reagin [RPR] titer > or = 1:8 and Treponema pallidum hemagglutination assay [TPHA]/fluorescent treponemal antibody [FTA] positive) and low-titer (n=249; RPR ..
- Molecular typing of Treponema pallidum causing early syphilis in China: a cross-sectional studyRui Rui Peng
National STD Reference Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, National Center for STD Control, Nanjing, China
Sex Transm Dis 39:42-5. 2012There have been limited data on molecular epidemiology of syphilis in China. This study aimed to analyze strain type distribution of Treponema pallidum causing early syphilis across geographic areas in China using an enhanced method.
- Etiology and determinants of sexually transmitted infections in Karnataka state, south IndiaMarissa Becker
Department of Medicine, University of Manitoba, 771 McDermot Avenue, Winnipeg, Manitoba, Canada
Sex Transm Dis 37:159-64. 2010..We undertook this study to better understand the etiology of STIs in adults in south India and to inform STI management guidelines...
- Clinical value of Treponema pallidum real-time PCR for diagnosis of syphilisR Heymans
Public Health Laboratory, Amsterdam Public Health Service, Amsterdam, The Netherlands
J Clin Microbiol 48:497-502. 2010..In the present study, therefore, we examined the additional clinical value of a Treponema pallidum real-time TaqMan PCR for the detection of primary and secondary syphilis. The additional value of the T...
- Detection of Treponema pallidum subsp. pallidum from skin lesions, serum, and cerebrospinal fluid in an infant with congenital syphilis after clindamycin treatment of the mother during pregnancyVladana Woznicová
Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic
J Clin Microbiol 45:659-61. 2007..Using PCR detection of tmpC (TP0319) and DNA sequencing of the genes TP0136 and TP0548, DNA sequences identical to Treponema pallidum subsp. pallidum strain SS14 were detected in the infant's skin lesions, serum, and cerebrospinal fluid.
- Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicityD R Akins
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235
Infect Immun 61:1202-10. 1993A murine monoclonal antibody specific for a 17-kDa major membrane immunogen of Treponema pallidum was used to select recombinant Escherichia coli clones expressing the molecule from a T. pallidum genomic library...
- Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartmentsAdriana R Cruz
Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
PLoS Negl Trop Dis 6:e1717. 2012The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation.
- Sequencing-based molecular typing of treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 strainMagdalena Flasarová
Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
Acta Derm Venereol 92:669-74. 2012..The variants of arp and tpr genes appear to combine independently with sequence variants of TP0136, TP0548 and 23S rRNA genes...
- Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene familyL V Stamm
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
FEMS Microbiol Lett 169:155-63. 1998TnphoA mutagenesis was used to identify genes encoding exported proteins in a genomic DNA library of Treponema pallidum, the syphilis agent...
- On-site rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinicsRachel N Bronzan
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Sex Transm Dis 34:S55-60. 2007..syphilis screening strategies at rural clinics: on-site rapid plasma reagin (RPR), on-site treponemal immunochromatographic strip (ICS) test, and the standard practice offsite RPR with Treponema pallidum hemagglutination assay (RPR/TPHA).
- CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilisBrandon T Leader
Department of Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
Infect Immun 75:3021-6. 2007The clearance of Treponema pallidum subsp. pallidum from early syphilis lesions involves infiltration of a large number of mononuclear cells and is characteristic of a cell-mediated immune response...
- Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backboneY H Lee
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8884, USA
Nat Struct Biol 6:628-33. 1999..of recombinant TroA, a zinc-binding protein component of an ATP-binding cassette transport system in Treponema pallidum, was determined at a resolution of 1.8 A...
- Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilisLorenzo Giacani
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Immunol 184:3822-9. 2010..In Treponema pallidum (T...
- Subfamily I Treponema pallidum repeat protein family: sequence variation and immunityEileen S Sun
Department of Pathobiology, University of Washington, Box 357185, 1959 NE Pacific Street, Seattle, WA 98195, USA
Microbes Infect 6:725-37. 2004A 12-membered Treponema pallidum repeat (Tpr) protein family has been identified in T. pallidum subsp. pallidum, the causative agent of syphilis...
- From microbial genome sequence to applicationsG M Weinstock
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, 77030, USA
Res Microbiol 151:151-8. 2000..These areas for technological development should be stimulated by the potential for converting genomic sequence information into applications...
- Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidumLorenzo Giacani
Department of Medicine, University of Washington, Seattle, WA, USA
FEMS Immunol Med Microbiol 51:289-301. 2007In Treponema pallidum, homopolymeric guanosine repeats of varying length are present upstream of both Subfamily I (tprC, D, F and I) and II (tprE, G and J) tpr genes, a group of potential virulence factors, immediately upstream of the +1 ..
- Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidumHsi Liu
National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Med Microbiol 56:715-21. 2007The acidic repeat protein (arp) genes from three subspecies of the treponeme Treponema pallidum (T. pallidum subsp. pallidum, Nichols strain; T. pallidum subsp. pertenue, CDC-1 and CDC-2 strains; and T. pallidum subsp...
- [Molecular detection and subtyping of Treponema pallidum subsp. pallidum in clinical specimens]M Flasarová
Biologický ustav, LF MU, Brno
Epidemiol Mikrobiol Imunol 55:105-11. 2006..the tmpC gene (TP0319, encoding putative membrane lipoprotein) was used for detection of chromosomal DNA of Treponema pallidum subsp. pallidum in clinical specimens...
- TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidumLorenzo Giacani
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Mol Microbiol 72:1087-99. 2009Transcriptional regulation in Treponema pallidum ssp. pallidum is poorly understood, primarily because this organism cannot be cultivated in vitro or genetically manipulated...
- Comparative analysis of immunohistochemistry, polymerase chain reaction and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilisH Muller
Department of Dermatology, Medical University Innsbruck, Innsbruck, Austria
Br J Dermatol 165:50-60. 2011..Depending on the disease stage, direct detection of Treponema pallidum in mucocutaneous lesions of syphilis may be difficult and histopathological findings are not always ..
- Serologic testing for syphilis in the United States: a cost-effectiveness analysis of two screening algorithmsKwame Owusu-Edusei
Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road MS E 80, Atlanta, GA 30333, USA
Sex Transm Dis 38:1-7. 2011..We compared the economic and health outcomes of this new algorithm with the standard algorithm from the perspective of the United States health system...
- Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomographyJun Liu
Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2 228, Houston, TX 77030, USA
J Mol Biol 403:546-61. 2010High-resolution cryo electron tomography (cryo-ET) was utilized to visualize Treponema pallidum, the causative agent of syphilis, at the molecular level...
- Molecular typing of Treponema pallidum: a systematic review and meta-analysisRui Rui Peng
National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China
PLoS Negl Trop Dis 5:e1273. 2011..This study aimed to review original research on molecular typing of Treponema pallidum (T...
- The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilisH Young
Scottish Bacterial Sexually Transmitted Infections Reference Laboratory, Department of Medical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, UK
Sex Transm Infect 85:19-23. 2009..To determine the sensitivity and specificity of the Architect Syphilis Chemiluminescence Assay (CLIA): a new highly automated screening test for syphilis...
- Syphilis. SerologyH Young
Scottish Neisseria gonorrhoeae Reference Laboratory, Edinburgh University Medical School, Scotland
Dermatol Clin 16:691-8. 1998..The role of the laboratory in aiding a diagnosis of neurosyphilis and congenital infection is discussed briefly, as is the current status of newer technologies, such as PCR and immunoblotting...
- Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidumPetra Matejková
Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
J Med Microbiol 58:832-6. 2009..The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic...
- A mgl-like operon in Treponema pallidum, the syphilis spirocheteS F Porcella
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235, USA
Gene 177:115-21. 1996A 38-kDa lipoprotein of Treponema pallidum subsp. pallidum (T. pallidum), the syphilis spirochete, previously was identified as a putative homolog of E. coli MglB [Becker et al. (1994) Infect. Immun. 62, 1381-1391]...
- Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the Rakai District, UgandaT R Suntoke
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Sex Transm Infect 85:97-101. 2009..predominant sexually transmitted aetiological agents of genital ulcer disease (GUD) (Haemophilus ducreyi, Treponema pallidum and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)) and to assess the use of real-time PCR ..
- Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidumA G Koek
Amsterdam Municipal Health Laboratory and Department of Infectious Diseases, Amsterdam, The Netherlands
Clin Microbiol Infect 12:1233-6. 2006A real-time PCR assay with a Taqman probe was developed that targeted the polA gene of Treponema pallidum. The test was validated using an analytical panel (n = 140) and a clinical panel of genital samples (n = 112) from patients ..
- Secondary syphilis in cali, Colombia: new concepts in disease pathogenesisAdriana R Cruz
Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, Cali, Colombia
PLoS Negl Trop Dis 4:e690. 2010Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp)...
- Detection of Treponema pallidum sp pallidum DNA in latent syphilisR Castro
Unidade de Doenças Sexualmente Transmitidas, IHMT, UNL, Lisboa, Portugal
Int J STD AIDS 18:842-5. 2007In this study, polymerase chain reaction (PCR) techniques were used to detect Treponema pallidum DNA in samples from patients with latent syphilis. Sixty-nine patients with latent syphilis and 18 with treated syphilis were included...
- Global challenge of antibiotic-resistant Treponema pallidumLOLA V STAMM
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
Antimicrob Agents Chemother 54:583-9. 2010..Macrolide-resistant strains of Treponema pallidum are now prevalent in several developed countries. An understanding of the genetic basis of T...
- Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, ChinaIrene E Martin
Division of Pathogenic Neisseria, Syphilis Diagnostics, Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Clin Infect Dis 49:515-21. 2009..This study focuses on implementing polymerase chain reaction (PCR) diagnostic tests for syphilis and for detection of molecular subtypes and macrolide resistance among strains causing primary syphilis in the city of Shanghai, China...
- Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit modelCecilia A Morgan
Departments of Pathobiology, University of Washington, Seattle 98195, USA
Infect Immun 70:6811-6. 2002When used as an immunogen, Treponema pallidum repeat protein K (TprK) has been shown to attenuate syphilitic lesions upon homologous intradermal challenge in the rabbit model...
- Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidumWesley C Van Voorhis
Departments of Medicine and Pathobiology, University of Washington, Seattle, Washington 98195, USA
J Clin Microbiol 41:3668-74. 2003Syphilis serodiagnosis relies on a combination of nonspecific screening tests (antilipoidal antibodies) and Treponema pallidum-specific tests (anti-T. pallidum antibodies). We studied a group of six recombinant T...
- Antigenic variation of TprK V regions abrogates specific antibody binding in syphilisRebecca E LaFond
Department of Pathobiology, University of Washington, Box 359779, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
Infect Immun 74:6244-51. 2006The tprK gene in the syphilis spirochete, Treponema pallidum subsp. pallidum, undergoes antigenic variation in seven variable (V) regions. tprK is highly variable within T...
- Assessment of a real-time PCR test to diagnose syphilis from diverse biological samplesA Gayet-Ageron
HIV Care Unit, Division of Infectious Diseases, Geneva s University Hospitals and School of Medicine, Geneva, Switzerland
Sex Transm Infect 85:264-9. 2009To investigate the contribution of a real-time PCR assay for the detection of Treponema pallidum in various biological specimens with the secondary objective of comparing its value according to HIV status.
- Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein KCecilia A Morgan
Department of Pathobiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Infect Immun 71:5605-12. 2003..It has been shown that the Treponema pallidum repeat protein K (TprK) differs in seven discrete variable (V) regions in isolates and that the antibody ..
- Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award LectureSheila A Lukehart
Department of Medicine, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
Sex Transm Dis 35:2-7. 2008
- Molecular typing of treponema pallidum clinical strains from Lisbon, PortugalC Florindo
Department of Infectious Diseases, Instituto Nacional de Saude Dr Ricardo Jorge, Av Padre Cruz, Lisbon 1649 016, Portugal
J Clin Microbiol 46:3802-3. 2008A molecular system was used to subtype Portuguese Treponema pallidum clinical strains isolated from both skin lesions and blood. The study with this system constitutes the first typing study in a European country. Three T...
- Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testingDavid E Leslie
Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
J Clin Microbiol 45:93-6. 2007..A TaqMan real-time PCR assay targeting the polA gene of Treponema pallidum (TpPCR) was developed. The analytical sensitivity of the assay was estimated to be 1...
- Syphilis at the crossroad of phylogenetics and paleopathologyFernando Lucas de Melo
Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
PLoS Negl Trop Dis 4:e575. 2010..Then, we selected the oldest ones to calibrate the time of the most recent common ancestor of Treponema pallidum subsp. pallidum, T. pallidum subsp. endemicum and T. pallidum subsp...
- Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCRJuan C Salazar
Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
Infect Immun 75:2954-8. 2007..We used real-time quantitative PCR to measure Treponema pallidum DNA levels in rabbits infected intratesticularly with the prototype Nichols strain...
- Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabsIrene E Martin
Division of Pathogenic Neisseria, Syphilis Diagnostics, and Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
J Clin Microbiol 47:1668-73. 2009Although detection of Treponema pallidum DNA in whole-blood specimens of syphilis patients has been reported, it is uncertain at what stage of the disease such specimens are most suitable for the molecular diagnosis of syphilis...
- Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reactionChao Chang Wu
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
J Am Acad Dermatol 55:S11-5. 2006..No spirochete could be found in the skin sections staining with Warthin-Starry stain. Using nested polymerase chain reaction, treponemal genomic DNA fragments encoding DNA polymerase I were detected...
- Production of tumor necrosis factor alpha by Treponema pallidum, Borrelia burgdorferi s.l., and Leptospira interrogans in isolated rat Kupffer cellsAntonella Marangoni
Sezione di Microbiologia DMCSS, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
FEMS Immunol Med Microbiol 40:187-91. 2004Stimulation of isolated rat Kupffer cells by viable Leptospira interrogans, Treponema pallidum and Borrelia garinii elicited cellular responses resulting in the release of different tumor necrosis factor alpha (TNF-alpha) levels, ..
- Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypesIrene E Martin
Division of Pathogenic Neisseria, Syphilis Diagnostics, and Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, Ontario, Canada
Sex Transm Dis 37:544-8. 2010..chain reaction diagnostic tests for syphilis, identifies macrolide resistance, and uses a molecular typing system to characterize Treponema pallidum clinical strains causing syphilis in Alberta and Northwest Territories, Canada.
- Redox-dependent structural changes in the superoxide reductase from Desulfoarculus baarsii and Treponema pallidum: a FTIR studyCatherine Berthomieu
CEA Cadarache, DSV DEVM, Laboratoire de Bioenergetique Cellulaire, UMR 163 CNRS CEA, Univ Méditerranée CEA 1000, Bât 156, F 13108 Saint Paul lez Durance, Cedex, France
Biochemistry 41:10360-8. 2002..structural changes at the active site of the superoxide reductase (SOR) from Desulfoarculus baarsii and Treponema pallidum have been monitored by means of FTIR difference spectroscopy coupled to electrochemistry...
- Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidumDerek Parsonage
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 107:6240-5. 2010Little is known about the mechanisms by which Treponema pallidum (Tp), the causative agent of syphilis, copes with oxidative stress as it establishes persistent infection within its obligate human host...
- Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, PortugalR Castro
Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal
J Clin Microbiol 47:2510-2. 2009The objectives of this study were to evaluate the reproducibility of a molecular method for the subtyping of Treponema pallidum subsp. pallidum and to discriminate strains of this microorganism from strains from patients with syphilis...
- Evaluation of azithromycin resistance in Treponema pallidum specimens from MadagascarKathleen Van Damme
Department of Medicine, Division of Infectious Diseases, University of North Carolina, Madagascar UNC Mad, Antananarivo, Madagascar
Sex Transm Dis 36:775-6. 2009b>Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland...
- The first crystal structure of class III superoxide reductase from Treponema pallidumTeresa Santos-Silva
REQUIMTE CQFB, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516, Caparica, Portugal
J Biol Inorg Chem 11:548-58. 2006..The crystal structure of Treponema pallidum (Tp) SOR was determined using soft X-rays and synchrotron radiation...
- Detection and discrimination of herpes simplex viruses, Haemophilus ducreyi, Treponema pallidum, and Calymmatobacterium (Klebsiella) granulomatis from genital ulcersIan M Mackay
Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Queensland, Australia
Clin Infect Dis 42:1431-8. 2006..This collaborative project was undertaken to address the need for a rapid, economical, and sensitive approach to the detection and diagnosis of GUD using noninvasive techniques to sample genital ulcers...
- Superoxide reductase from the syphilis spirochete Treponema pallidum: crystallization and structure determination using soft X-raysTeresa Santos-Silva
REQUIMTE Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:967-70. 2005..The oxidized form of Treponema pallidum superoxide reductase was crystallized in the presence of polyethylene glycol and magnesium chloride...
- Treponema pallidum macrolide resistance in BCMuhammad G Morshed
CMAJ 174:349. 2006
- Alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infectionC M Marra
Department of Medicine, University of Washington, Seattle
J Infect Dis 165:1020-5. 1992..After intradermal inoculation with Treponema pallidum, 2 SIV-infected monkeys had persistent ulcerative primary lesions and 1 developed secondary syphilis...
- Detection of the 47-kilodalton membrane immunogen gene of Treponema pallidum in various tissue sources of patients with syphilisAlexander Vasilevich Kouznetsov
Laboratory of Immune Pathogenesis and Serology, Department of Dermatology and Allergology, Ludwig Maximilians University of Munich, 80337 Munich, Germany
Diagn Microbiol Infect Dis 51:143-5. 2005Polymerase chain reaction (PCR) was used to detect the 47-kDa immunogen gene of Treponema pallidum in peripheral blood mononuclear cells (PBMCs), skin lesions, and serum, but less consistently in purified granulocytes or ejaculates of ..
- Comparison of a Treponema pallidum IgM immunoblot with a 19S fluorescent treponemal antibody absorption test for the diagnosis of congenital syphilisMartina Herremans
Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Laboratory for Infectious Diseases and Perinatal Screening, PO Box 1, 3720 BA Bilthoven, The Netherlands
Diagn Microbiol Infect Dis 59:61-6. 2007We compared an in-house Treponema pallidum IgM immunoblot (IB) with a 19S fluorescent treponemal antibody absorption (IgM) test during routine use for the diagnosis of congenital syphilis (CS) in a national reference laboratory in a ..
- Genital ulcer disease in men in Durban, South AfricaN O'Farrell
City Health STD Department, King Edward VIII Hospital, Durban, South Africa
Genitourin Med 67:327-30. 1991..To study the microbial aetiology of genital ulcer disease (GUD) in men...
- Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirocheteD V Shevchenko
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
Infect Immun 65:4179-89. 1997..5 kDa, which had been identified previously in OM fractions from Treponema pallidum (J. D. Radolf et al., Infect. Immun. 63:4244-4252, 1995)...
- Identification and sequences of the Treponema pallidum mglA and mglC genesL V Stamm
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
DNA Seq 6:293-8. 1996b>Treponema pallidum, the agent of syphilis, cannot be continuously cultivated in vitro. To identify treponemal genes encoding exported proteins, we performed TnphoA mutagenesis of a T. pallidum genomic DNA library in Escherichia coli...
- Prevalence of circulating Treponema pallidum DNA and RNA in blood donors with confirmed-positive syphilis testsSharyn L Orton
American Red Cross Holland Laboratory, Rockville, Maryland, USA
Transfusion 42:94-9. 2002..DNA PCR and RNA RT-PCR were applied to assess the presence of Treponema pallidum DNA or RNA in blood donors with confirmed-positive results in STS.
- Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1)D R Blanco
Department of Microbiology and Immunology, School of Medicine, University of California at Los Angeles 90024, USA
J Bacteriol 177:3556-62. 1995We have recently reported the isolation and purification of the Treponema pallidum outer membrane and the identification of its rare protein constituents, including a 31-kDa protein markedly enriched in the outer membrane preparation (D.R...
- Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologueC E Stebeck
Department of Medicine, University of Washington, Seattle 98195, USA
FEMS Microbiol Lett 154:303-10. 1997To identify potential opsonic targets of Treponema pallidum subsp. pallidum, a treponemal genomic expression library was constructed and differentially screened with opsonic and non-opsonic T. pallidum antisera...
- Pulse radiolysis studies on superoxide reductase from Treponema pallidumV Niviere
Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université Joseph Fourier, Cedex 9, France
FEBS Lett 497:171-3. 2001..The reaction of the enzyme from Treponema pallidum with superoxide was studied by pulse radiolysis methods...
- Immunization with Treponema pallidum outer membrane vesicles induces high-titer complement-dependent treponemicidal activity and aggregation of T. pallidum rare outer membrane proteins (TROMPs)D R Blanco
Department of Microbiology, Immunology, and Molecular Genetics, School of Medicine, University of California, Los Angeles 90024, USA
J Immunol 163:2741-6. 1999..purpose of this study was to determine whether immunization with purified outer membrane vesicles (OMV) from Treponema pallidum (T.p. ) could elicit Abs capable of killing this organism...
- Use of the polymerase chain reaction to detect DNA sequences specific to pathogenic treponemes in cerebrospinal fluidP E Hay
Clinical Research Centre, Harrow, Middlesex, London
FEMS Microbiol Lett 56:233-8. 1990The polymerase chain reaction was used to detect Treponema pallidum in specimens of cerebrospinal fluid (CSF), as a means of diagnosing syphilis...
- Contribution of neelaredoxin to oxygen tolerance by Treponema pallidumKarsten R O Hazlett
Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Methods Enzymol 353:140-56. 2002
- Testing umbilical cords for funisitis due to Treponema pallidum infection, BoliviaJ Guarner
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 6:487-92. 2000..Testing umbilical cords by using immunohistochemistry is a research tool that can establish the frequency of funisitis due to Treponema pallidum infection.
- Insertion of fluorescent fatty acid probes into the outer membranes of the pathogenic spirochaetes Treponema pallidum and Borrelia burgdorferiD L Cox
The Bacterial STD Branch, Centers for Disease Control and Prevention, Mailstop D 13, 1600 Clifton Rd, Atlanta, GA 30333, USA
Microbiology 147:1161-9. 2001..of 5-aminofluorescein (OAF, HAF and DAF, respectively) to insert into the outer membranes (OMs) of Treponema pallidum, Borrelia burgdorferi and Escherichia coli...
- On the origin of the treponematoses: a phylogenetic approachKristin N Harper
Department of Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, United States of America
PLoS Negl Trop Dis 2:e148. 2008..Since the first recorded epidemic of syphilis in 1495, controversy has surrounded the origins of the bacterium Treponema pallidum subsp...
- The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidumRanjit K Deka
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 281:8072-81. 2006b>Treponema pallidum, the bacterial agent of syphilis, cannot be cultivated in vitro. This constraint has severely impeded the study of the membrane biology of this complex human pathogen...
- A unique approach to identify markers for congenital syphilis and neurosyphilisNikhat Parveen; Fiscal Year: 2010..and treatment of rare diseases, Syphilis is a chronic, multisystemic disease caused by the spirochete, Treponema pallidum subspecies pallidum (T. pallidum). The spirochete is acquired by sexual contact and is prevalent worldwide...
- Functional Consequence of Macrolide Resistance Mutations in T. pallidumSheila A Lukehart; Fiscal Year: 2012..of this form of penicillin to achieve treponemacidal levels in the central nervous system (a common site for Treponema pallidum dissemination)...
- 2009 Spirochetes, Biology ofDavid A Haake; Fiscal Year: 2010..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
- Antigenic Variation of TprK in Treponema pallidumSheila A Lukehart; Fiscal Year: 2013..variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
- Outer membrane proteins of Borrelia burgdorferiDarrin R Akins; Fiscal Year: 2013..burgdorferi and Treponema pallidum, but could potentially be widely applicable against other important human pathogens, such as E...
- Multiple Antigen Point-of-Care Device for Improved Syphilis DiagnosisMichael J Lochhead; Fiscal Year: 2010..It is a sexually transmitted and congenital disease caused by the bacterium Treponema pallidum. When properly diagnosed, it is readily treatable with relatively inexpensive antimicrobial therapies...
- CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILISGeorge W Ordal; Fiscal Year: 2012..Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp., and Treponema pallidum have homologues to CheC, CheD, and CheV, genes first identified and then characterized in B. subtilis.
- Natural competence and genetic manipulation of Treponema pallidumLorenzo Giacani; Fiscal Year: 2012..the disease, but such progress is greatly limited by the current assumption that the agent of syphilis, Treponema pallidum subsp. pallidum (T...
- Mechanisms of Immune Evasion and Recognition in Human SyphilisADRIANA RAQUEL CRUZ; Fiscal Year: 2013..provided by applicant): Syphilis, a multi-stage sexually transmitted disease caused by the spirochete Treponema pallidum (Tp), continues to be a major worldwide public health problem...
- Lumbar Puncture and Syphilis OutcomeChristina M Marra; Fiscal Year: 2013..b>Treponema pallidum invades the central nervous system (CNS) early in disease, and benzathine penicillin G (BPG), the ..
- Treponema pallidum:Pathogenesis-associated moleculesSheila A Lukehart; Fiscal Year: 2013..Millions of people have been, and continue to be, infected by pathogenic Treponema, including the three Treponema pallidum subspecies and Treponema carateum...
- Structure and Function of Treponema pallidum LipoproteinsMichael V Norgard; Fiscal Year: 2013DESCRIPTION (provided by applicant): Syphilis, caused by the spirochetal bacterium Treponema pallidum, continues to play prominently as a sexually transmitted disease...
- Characterization of Treponema pallidum rare outer membrane proteinsJustin D Radolf; Fiscal Year: 2013DESCRIPTION (provided by applicant): More than a century after the discovery of Treponema pallidum (Tp), syphilis remains a major threat to global public health...
- ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORKAnna Barbara Moscicki; Fiscal Year: 2001..the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the development ..
- Extracellular Matix Adhesins of Treponema pallidumCaroline E Cameron; Fiscal Year: 2013..The bacterium that causes syphilis, Treponema pallidum, is able to disseminate rapidly within the host during the early stages of infection to infect every organ ..
- Anti-HIV-1 Composite Cellulose Acetate Phthalate FilmShibo Jiang; Fiscal Year: 2006..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
- Pathoadaptive Mutations in Treponema Pallidum, the SyphilisLorenzo Giacani; Fiscal Year: 2013DESCRIPTION (provided by applicant): Syphilis is a significant problem for global health. It is caused by Treponema pallidum subsp. pallidum (T. palidum), a highly virulent, invasive and intractable spirochete...
- GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETESJANIS WEIS; Fiscal Year: 2004..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
- GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETESJANIS WEIS; Fiscal Year: 2002..The application of genetic advancements and the availability of genomic sequences of Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp, are proving a wealth of new information...
- GENE ANALYSIS OF SPIROCHETE PERIPLASMIC FLAGELLANYLES CHARON; Fiscal Year: 1999..These spirochetes have PFs very similar to those found in Treponema pallidum, the causative agent for syphilis. T...
- PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUMSteven Norris; Fiscal Year: 1993b>Treponema pallidum subsp. pallidum and related organisms are helically- shaped bacteria which cause venereal syphilis, endemic syphilis, yaws and pinta in humans...
- Borrelia lipoproteins with the cerebral microcirculationDiego Cadavid; Fiscal Year: 2007..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
- A Novel Approach to the Development of a Syphilis Vaccine Using Rabbit MonoclonalJames Miller; Fiscal Year: 2009..The focus of this proposal is the isolation of rabbit monoclonal antibodies directed against Treponema pallidum surface antigens that are targets of treponemicidal activity...
- GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETESSteven Norris; Fiscal Year: 2000..However, the recent publication of the genomic sequences for Borrelia burgdorferi and Treponema pallidum, and a newly initiated project for sequencing the Treponema denticola genome, provide a wealth of new ..
- STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINSWILHELMUS HOL; Fiscal Year: 2004..These include Mtb-IdeR from Mycobacterium tuberculosis, TroR from Treponema pallidum, SirR from Staphylococcus epidermis and DtxR from Corynebacterium diphtheriae...
- FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUMTimothy Palzkill; Fiscal Year: 2006..A functional genomics approach will be used to identify proteins important for the Treponema pallidum host-pathogen interaction. T. pallidum is the causative agent of syphilis...
- SEQUENCING OF THE HAEMOPHILUS DUCREYI GENOMERobert Munson; Fiscal Year: 1999..a integrated data base with detailed annotation of sequences from sexually transmitted pathogens including Treponema pallidum, Neisseria gonorrhoeae and Chlamydia trachomatis. Genome sequences for these organisms are near completion...
- MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENESRONALD LIMBERGER; Fiscal Year: 2002..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema denticola)...
- PROGRAM ON SEXUALLY TRANSMITTED DISEASESJoel Baseman; Fiscal Year: 1992..Project 2 focuses on the host-treponeme interaction, with major emphasis on the adhesins of Treponema pallidum and receptors of host cells...
- Systemic Innate Immune Responses in Secondary SyphilisJuan C Salazar; Fiscal Year: 2010..by applicant): Venereal syphilis is a sexually transmitted disease caused by the spirochetal pathogen, Treponema pallidum. The disease remains uncontrolled, particularly in resource-scarce regions where testing, treatment and ..
- Sexually Transmitted Infections & Antimicrobial PeptidesWilliam Shafer; Fiscal Year: 2009..gonorrhoeae and can block infection by Treponema pallidum in a rabbit skin lesion model...
- MEMBRANE PROTEINS OF TREPONEMA PALLIDUMMICHAEL NORGARD; Fiscal Year: 2009..the oldest recognized STDs, syphilis remains among the most poorly understood, largely due to the fact that Treponema pallidum cannot be cultivated in vitro...
- SURFACE & EXTRACELLULAR ANTIGENS OF T PALLIDUMLola Stamm; Fiscal Year: 1991..Research on Treponema pallidum, the etiological agent of syphilis, has been hampered by the inability to successfully culture the ..
- INTERACTION OF PATHOGENIC SPIROCHETES WITH HOST CELLSD Thomas; Fiscal Year: 1993..Investigations of the pathogenesis of syphilis are limited by lack of an in vitro growth system for Treponema pallidum. In comparison, growth of the Lyme disease agent, Borrelia burgdorferi, in culture makes this organism ..
- SEXUALLY TRANSMITTED DISEASEPhilip Sparling; Fiscal Year: 1990..Project 5 (P. Bassford, PI) will examine the metabolism of Treponema pallidum, using molecular genetic techniques to isolate a wide variety of T. Pallidum genes in E. coli hosts...
- MEMBRANE PROTEINS OF TREPONEMA PALLIDUMJustin Radolf; Fiscal Year: 1991Previous studies have demonstrated that the outer membrane of Treponema pallidum is physically labile and has the ability to resist binding of specific antibody...
- EFFECT OF MARIJUANA ON EXPERIMENTAL SYPHILIS IN RABBITSLOIS PARADISE; Fiscal Year: 1992..dose-response experiments will test a range of concentrations of THC against a range of infecting doses of Treponema pallidum subsp. pallidum, the causative agent of syphilis...
- IMMUNOBIOLOGY AND PATHOGENESIS OF INFECTIONS IN INFANTSGEORGE MC CRACKEN; Fiscal Year: 1991..susceptibility of infants and children for disease caused by Haemophilus influenzae, Neisseria meningitidis, Treponema pallidum, group B Streptococcus, enterotoxin-producing Escherichia coli and Pseudomonas aeruginosa...
- ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASIONChristina Marra; Fiscal Year: 2004..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
- Rapid and Simple CSF Tests for Neurosyphillis DiagnosisChristina Marra; Fiscal Year: 2006..The results of this study will be used to design field trials in the areas of greatest need. ..
- Novel Methods to Access Brain Function in HIV-1Christina Marra; Fiscal Year: 2003..abstract_text> ..
- Immunity in Early Syphillis: Pathway to HIV CoinfectionJuan Salazar; Fiscal Year: 2007..Research: Syphilis is caused by the spirochetal pathogen Treponema pallidum and it is well recognized as a risk factor for transmission of HIV...
- Risks for HIV and STIs among Moscow Sex WorkersChris Beyrer; Fiscal Year: 2005..abstract_text> ..
- MOLECULAR IMMUNOLOGY OF SYPHILISSheila Lukehart; Fiscal Year: 2003..Recently, a new gene family was discovered in Treponema pallidum. The proteins encoded by these genes have homology to the major sheath protein (msp) of a related spirochete,..
- INTERACTION OF ORAL SPIROCHETES WITH GINGIVAL EPITHELIUMSheila Lukehart; Fiscal Year: 2007..This study will further our understanding of the pathogenesis of periodontal disease by providing a more complete understanding of how T. denticola and other oral spirochetes evade the innate immune response. ..
- CD1 RESTRICTED T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUSPETER SIELING; Fiscal Year: 2003..Finally, we anticipate that our findings will be useful in establishing new mains of treating autoimmune disease. ..
- Antigenic variation in rickettsial transmissionGuy Palmer; Fiscal Year: 2008..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
- Acquisition of a 600 MHz NMR Spectrometer - Wayne StateShahriar Mobashery; Fiscal Year: 2002..The availability of this instrument would stimulate further research in structural biology at Wayne State University, enhancing the strong existing capabilities that we enjoy in X-ray structure determination. ..