treponema

Summary

Summary: A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man.

Top Publications

  1. pmc Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 6:e20415. 2011
  2. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
  3. pmc Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A
    Michal Strouhal
    Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    Infect Immun 75:5859-66. 2007
  4. doi Treponema species detected in infected root canals and acute apical abscess exudates
    Francisco Montagner
    Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental School, State University of Campinas, UNICAMP, Piracicaba, SP, Brazil
    J Endod 36:1796-9. 2010
  5. ncbi "Red complex" (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola) in endodontic infections: a molecular approach
    I N Rôças
    Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:468-71. 2001
  6. ncbi The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease
    W J Loesche
    University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Dent Res 69:1696-702. 1990
  7. ncbi Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene family
    L V Stamm
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    FEMS Microbiol Lett 169:155-63. 1998
  8. doi Treponema pedis sp. nov., a spirochaete isolated from bovine digital dermatitis lesions
    Nicholas J Evans
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    Int J Syst Evol Microbiol 59:987-91. 2009
  9. pmc Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Bacteriol 194:4208-25. 2012
  10. doi Bovine digital dermatitis: possible pathogenic consortium consisting of Dichelobacter nodosus and multiple Treponema species
    Marianne Rasmussen
    Technical University of Denmark, National Veterinary Institute, Copenhagen, Denmark
    Vet Microbiol 160:151-61. 2012

Detail Information

Publications222 found, 100 shown here

  1. pmc Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 6:e20415. 2011
    b>Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis...
  2. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
    We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T...
  3. pmc Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A
    Michal Strouhal
    Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    Infect Immun 75:5859-66. 2007
    The genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp...
  4. doi Treponema species detected in infected root canals and acute apical abscess exudates
    Francisco Montagner
    Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental School, State University of Campinas, UNICAMP, Piracicaba, SP, Brazil
    J Endod 36:1796-9. 2010
    ..b>Treponema species are strict anaerobic bacteria that are involved in several oral diseases...
  5. ncbi "Red complex" (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola) in endodontic infections: a molecular approach
    I N Rôças
    Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:468-71. 2001
    The "red complex," composed of Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola, is implicated in severe forms of periodontal diseases...
  6. ncbi The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease
    W J Loesche
    University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Dent Res 69:1696-702. 1990
    b>Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus each possesses an enzyme(s) that hydrolyzes the synthetic substrate benzoyl-DL-arginine-naphthylamide (BANA)...
  7. ncbi Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene family
    L V Stamm
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    FEMS Microbiol Lett 169:155-63. 1998
    TnphoA mutagenesis was used to identify genes encoding exported proteins in a genomic DNA library of Treponema pallidum, the syphilis agent...
  8. doi Treponema pedis sp. nov., a spirochaete isolated from bovine digital dermatitis lesions
    Nicholas J Evans
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    Int J Syst Evol Microbiol 59:987-91. 2009
    ..treponeme phylotypes have been identified in BDD lesions, although only a single BDD-associated treponeme taxon (Treponema brennaborense) has been proposed thus far...
  9. pmc Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Bacteriol 194:4208-25. 2012
    Although the three Treponema pallidum subspecies (T. pallidum subsp. pallidum, T. pallidum subsp. pertenue, and T. pallidum subsp...
  10. doi Bovine digital dermatitis: possible pathogenic consortium consisting of Dichelobacter nodosus and multiple Treponema species
    Marianne Rasmussen
    Technical University of Denmark, National Veterinary Institute, Copenhagen, Denmark
    Vet Microbiol 160:151-61. 2012
    ..Virulent phylotypes of Treponema and other infectious agents contributing to disease etiology still remain to be identified...
  11. pmc Comparison of the benzoyl-DL-arginine-naphthylamide (BANA) test, DNA probes, and immunological reagents for ability to detect anaerobic periodontal infections due to Porphyromonas gingivalis, Treponema denticola, and Bacteroides forsythus
    W J Loesche
    Department of Biological and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Clin Microbiol 30:427-33. 1992
    ..of periodontal disease are associated with the presence or overgrowth of anaerobic species that could include Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus among others...
  12. pmc Characterization of novel bovine gastrointestinal tract Treponema isolates and comparison with bovine digital dermatitis treponemes
    Nicholas J Evans
    School of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    Appl Environ Microbiol 77:138-47. 2011
    ..obtained from the bovine GI tract, which, on the basis of 16S rRNA gene comparisons, clustered within the genus Treponema as four novel phylotypes...
  13. ncbi The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis
    Kristin N Harper
    Department of Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
    FEMS Immunol Med Microbiol 53:322-32. 2008
    Despite the completion of the Treponema pallidum genome project, only minor genetic differences have been found between the subspecies that cause venereal syphilis (ssp. pallidum) and the nonvenereal diseases yaws (ssp...
  14. pmc Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola
    R Lux
    School of Dentistry and Molecular Biology Institute, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095-1668, USA
    Infect Immun 69:6276-83. 2001
    ..the role of motility and chemotaxis in tissue penetration by the periodontal disease-associated oral spirochete Treponema denticola using an oral epithelial cell line-based experimental approach. Wild-type T...
  15. pmc Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the first spirochetes isolated from termite guts
    Joseph R Graber
    Department of Microbiology and Molecular Genetics and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824 4320, USA
    Appl Environ Microbiol 70:1315-20. 2004
    ..A. Breznak, Science 292:2495-2498, 2001). However, application of specific epithets to the strains isolated (Treponema strains ZAS-1, ZAS-2, and ZAS-9) was postponed pending a more complete characterization of their phenotypic ..
  16. pmc Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp
    J C Fenno
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Bacteriol 179:1082-9. 1997
    The major surface protein (Msp) of Treponema denticola has been implicated as a mediator of the interaction between the spirochete and the gingival epithelium in periodontal diseases. Previous studies showed that the Msp of T...
  17. pmc Cytoplasmic filament-deficient mutant of Treponema denticola has pleiotropic defects
    J Izard
    Wadsworth Center, David Axelrod Institute for Public Health, New York State Department of Health, Albany, New York 12201 2002, USA
    J Bacteriol 183:1078-84. 2001
    In Treponema denticola, a ribbon-like structure of cytoplasmic filaments spans the cytoplasm at all stages of the cell division process...
  18. pmc Oral spirochetes implicated in dental diseases are widespread in normal human subjects and carry extremely diverse integron gene cassettes
    Yu Wei Wu
    School of Informatics and Computing, Indiana University, Bloomington, Indiana, USA
    Appl Environ Microbiol 78:5288-96. 2012
    ..diseases in normal human individuals, using recombination sites associated with the chromosomal integron in Treponema genomes, taking advantage of the multiple copies of the integron recombination sites (repeats) in the genomes, ..
  19. ncbi Treponema amylovorum sp. nov., a saccharolytic spirochete of medium size isolated from an advanced human periodontal lesion
    C Wyss
    Institut für Orale Mikrobiologie und Allgemeine Immunologie, Zentrum fur Zahn, Mund und Kieferheilkunde, Universitat Zurich, Switzerland
    Int J Syst Bacteriol 47:842-5. 1997
    ..B. K. Choi, B. J. Paster, F. E. Dewhirst, and U. B. Göbel, Infect. Immun. 62:1889-1895, 1994). The only isolate, strain HA2P, is designated the type strain of a novel species, for which we propose the name Treponema amylovorum.
  20. pmc Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme
    H I Krupka
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, 82152 Martinsried, Germany
    EMBO J 19:3168-78. 2000
    Cystalysin is a C(beta)-S(gamma) lyase from the oral pathogen Treponema denticola catabolyzing L-cysteine to produce pyruvate, ammonia and H(2)S...
  21. pmc Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated
    C Wyss
    Institut für Orale Mikrobiologie und Allgemeine Immunologie, Zentrum fur Zahn, Mund und Kieferheilkunde der Universität Z urich, CH 8028 Zurich, Switzerland
    Infect Immun 66:5751-4. 1998
    Glycosylation of the flagellar core proteins (FlaBs) was detected in Treponema pallidum Nichols and in the type or reference strains of seven oral Treponema species...
  22. ncbi Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases
    C Wyss
    Institut für Orale Mikrobiologie und Allgemeine Immunologie, Zentrum fur Zahn, Mund und Kieferheilkunde, Universitat Zurich, Switzerland
    Int J Syst Bacteriol 49:1329-39. 1999
    ..hybridization and 16S rDNA sequence comparison, these spirochaetes form a distinct phylogenetic group, with Treponema maltophilum as its closest cultivable relative...
  23. ncbi Prostaglandin E(2) is a main mediator in receptor activator of nuclear factor-kappaB ligand-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii
    Bong Kyu Choi
    Department of Oromaxillofacial Infection and Immunity, College of Dentistry, Seoul National University, Seoul, Korea
    J Periodontol 76:813-20. 2005
    ..To understand the mechanism of how periodontopathogens induce osteoclastogenesis, we determined which mediators are involved in the osteoclastogenesis...
  24. doi Phylogenetic diversity and dietary association of rumen Treponema revealed using group-specific 16S rRNA gene-based analysis
    Aschalew Z Bekele
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    FEMS Microbiol Lett 316:51-60. 2011
    b>Treponema spp. are a commonly detected bacterial group in the rumen that are involved in the degradation of soluble fibers...
  25. ncbi Isolation of spirochetes of genus Treponema from pigs with ear necrosis
    Marit Pringle
    Dept of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, SE 75007 Uppsala, Sweden
    Vet Microbiol 139:279-83. 2009
    ..From an ear lesion a pure spirochete isolate was obtained and identified as a yet unnamed species of genus Treponema, closely related to spirochetes found in digital dermatitis in cattle...
  26. doi Identification of immunogenic proteins in Treponema phagedenis-like strain V1 from digital dermatitis lesions by phage display
    Anna Rosander
    Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7009, SE 750 07 Uppsala, Sweden
    Vet Microbiol 153:315-22. 2011
    ..In this study, shotgun phage display was used to identify immunogenic proteins in a strain (V1) of the Treponema phylotype closely related to Treponema phagedenis, indicated as a key agent in the pathogenesis of DD...
  27. ncbi Treponema socranskii, Treponema denticola, and Porphyromonas gingivalis are associated with severity of periodontal tissue destruction
    Y Takeuchi
    Division of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontol 72:1354-63. 2001
    The aim of the present study was to identify Treponema socranskii in addition to Treponema denticola and Porphyromonas gingivalis by polymerase chain reaction (PCR), and to clarify the relationship between the presence of these ..
  28. ncbi Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
    B Opitz
    , , Humboldt-University, 10117 Berlin, Germany
    J Biol Chem 276:22041-7. 2001
    ..Glycolipids from Treponema maltophilum and Treponema brennaborense, as well as highly purified LTAs from Staphylococcus aureus and Bacillus ..
  29. ncbi Effects of the oral spirochete Treponema denticola on interleukin-8 expression from epithelial cells
    Q D Deng
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    Oral Microbiol Immunol 16:185-7. 2001
    This communication demonstrates that the interaction of the oral spirochete Treponema denticola 35405 with KB epithelial cells does not lead to the induction of interleukin-8 production as occurs with a variety of other bacteria...
  30. pmc Detection of Treponema denticola in atherosclerotic lesions
    K Okuda
    Oral Health Science Center, Tokyo Dental College, 1 2 2, Masago, Mihama ku, Chiba, Japan
    J Clin Microbiol 39:1114-7. 2001
    ..b>Treponema denticola sequence of the 16S rRNA locus was found in 6 out of 26 DNA samples (23...
  31. pmc Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression
    Lianrui Chu
    Department of Periodontics, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Infect Immun 70:1113-20. 2002
    ..b>Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabolizes ..
  32. doi Growth curves and morphology of three Treponema subtypes isolated from digital dermatitis in cattle
    D Döpfer
    Department of Medical Sciences, University of Wisconsin, School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53706, USA
    Vet J 193:685-93. 2012
    ..Spirochetal bacteria of the genera Treponema have been implicated in DD infections following their isolation using culture techniques, serological detection ..
  33. ncbi Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin
    Mariarita Bertoldi
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Biochemistry 41:9153-64. 2002
    To obtain insight into the functional properties of Treponema denticola cystalysin, we have analyzed the pH- and ligand-induced spectral transitions, the pH dependence of the kinetic parameters, and the substrate specificity of the ..
  34. ncbi Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis
    C Wyss
    Institut für Orale Mikrobiologie und Allgemeine Immunologie, Zentrum fur Zahn, Mund und Kieferheilkunde der Universität Zürich, Plattenstrasse 11, CH 8028 Zurich, Switzerland
    Int J Syst Evol Microbiol 54:1117-22. 2004
    ..in cultured oral treponemes with trypsin-like proteolytic activity, and all have been assigned to the species Treponema denticola...
  35. pmc Conservation of the C-type lectin fold for massive sequence variation in a Treponema diversity-generating retroelement
    Johanne Le Coq
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:14649-53. 2011
    ..problem by determining the structure of a second DGR variable protein, TvpA, from the pathogenic oral spirochete Treponema denticola...
  36. ncbi Genetic analysis of Treponema denticola ATCC 35405 biofilm formation
    Peter M Vesey
    Department of Oral Biology, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214 3092, USA
    Microbiology 150:2401-7. 2004
    b>Treponema denticola is a major aetiological organism implicated in periodontal disease. The interaction of T...
  37. ncbi Treponema medium sp. nov., isolated from human subgingival dental plaque
    T Umemoto
    Department of Oral Microbiology, School of Dentistry, Asahi University, Gifu, Japan
    Int J Syst Bacteriol 47:67-72. 1997
    A new Treponema species, for which we propose the name Treponema medium, was isolated from subgingival plaque from an adult with periodontal disease...
  38. ncbi Proteolytic activity among various oral Treponema species and cloning of a prtP-like gene of Treponema socranskii subsp. socranskii
    K Heuner
    Institut für Moleculare Infektionsbiologie der Universität Würzburg, Germany
    FEMS Microbiol Lett 201:169-76. 2001
    ..Southern blot analysis using a Treponema socranskii subsp...
  39. pmc Antagonistic effect of oral bacteria towards Treponema denticola
    D Grenier
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec, Canada
    J Clin Microbiol 34:1249-52. 1996
    This study was designed to isolate oral bacteria exhibiting antagonism towards Treponema denticola and to characterize the inhibitory activity...
  40. pmc The opdB locus encodes the trypsin-like peptidase activity of Treponema denticola
    J C Fenno
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Infect Immun 69:6193-200. 2001
    High levels of Treponema denticola in subgingival dental plaque are associated with severe periodontal disease. T...
  41. ncbi Role of dentilisin in Treponema denticola epithelial cell layer penetration
    Bo Chi
    Department of Oral Biology, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Res Microbiol 154:637-43. 2003
    b>Treponema denticola is an oral anaerobic spirochete implicated in periodontal diseases. The chymotrypsin-like protease, dentilisin (PrtP), has been suggested to be an important virulence factor of T. denticola...
  42. pmc Heterologous expression of the Treponema pallidum laminin-binding adhesin Tp0751 in the culturable spirochete Treponema phagedenis
    Caroline E Cameron
    Department of Biochemistry and Microbiology, University of Victoria, 3800 Finnerty Road, Victoria, BC, Canada V8W 3P6
    J Bacteriol 190:2565-71. 2008
    b>Treponema pallidum subsp. pallidum, the causative agent of syphilis, is an unculturable, genetically intractable bacterium. Here we report the use of the shuttle vector pKMR4PEMCS for the expression of a previously identified T...
  43. pmc Identification of a novel, invasive, not-yet-cultivated Treponema sp. in the large intestine of pigs by PCR amplification of the 16S rRNA gene
    Lars Mølbak
    Danish Institute for Food and Veterinary Research, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    J Clin Microbiol 44:4537-40. 2006
    ..The 16S rRNA gene was PCR amplified, and the closest related type strain was Treponema bryantiiT (90.1%)...
  44. ncbi Activation of matrix metalloproteinase-2 by a novel oral spirochetal species Treponema lecithinolyticum
    B K Choi
    Department of Oral Biology, College of Dentistry and Brain Korea 21 Project of Medical Sciences, Yonsei University, Seoul
    J Periodontol 72:1594-600. 2001
    ..In order to elucidate the etiologic role of oral spirochetes, we investigated the effects of Treponema lecithinolyticum, a novel saccharolytic species, on MMP-2 activation...
  45. ncbi Treponema denticola cystalysin catalyzes beta-desulfination of L-cysteine sulfinic acid and beta-decarboxylation of L-aspartate and oxalacetate
    Barbara Cellini
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    FEBS Lett 554:306-10. 2003
    Pyridoxal 5'-phosphate-dependent cystalysin from Treponema denticola catalyzes the beta-displacement of the beta-substituent from both L-aspartate and L-cysteine sulfinic acid...
  46. ncbi Genetic relatedness and phenotypic characteristics of Treponema associated with human periodontal tissues and ruminant foot disease
    Andrew M Edwards
    Oral Microbiology Unit, Department of Oral and Dental Science, University of Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK
    Microbiology 149:1083-93. 2003
    b>Treponema have been implicated recently in the pathogenesis of digital dermatitis (DD) and contagious ovine digital dermatitis (CODD) that are infectious diseases of bovine and ovine foot tissues, respectively...
  47. pmc Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola
    J C Fenno
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Bacteriol 178:2489-97. 1996
    The gene encoding the major outer sheath protein (Msp) of the oral spirochete Treponema denticola ATCC 35405 was cloned, sequenced, and expressed in Escherichia coli...
  48. ncbi Adherence of human oral spirochetes by collagen-binding proteins
    T Umemoto
    Department of Oral Microbiology, School of Dentistry, Asahi University, Gifu, Japan
    Microbiol Immunol 41:917-23. 1997
    ..IV-, and V-collagen-binding polypeptides (CBPs) were detected in the heated and unheated preparations from both Treponema denticola ATCC 33520 and T. socranskii subsp. buccale ATCC 35534...
  49. pmc Physiology and nutrition of Treponema primitia, an H2/CO2-acetogenic spirochete from termite hindguts
    Joseph R Graber
    Department of Microbiology and Molecular Genetics and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA
    Appl Environ Microbiol 70:1307-14. 2004
    b>Treponema primitia strains ZAS-1 and ZAS-2, the first spirochetes to be isolated from termite hindguts (J. R. Leadbetter, T. M. Schmidt, J. R. Graber, and J. A...
  50. doi Prevalence of bovine papillomavirus and Treponema DNA in bovine digital dermatitis lesions
    Sabine Brandt
    Equine Biotechnology Unit, Equine Clinic, Veterinary University Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Vet Microbiol 148:161-7. 2011
    ..intact skin from 8 BDD-affected and 33 healthy cows were assessed for the presence of bovine papillomavirus and Treponema DNA...
  51. pmc Evidence of multiple Treponema phylotypes involved in bovine digital dermatitis as shown by 16S rRNA gene analysis and fluorescence in situ hybridization
    Kirstine Klitgaard
    National Veterinary Institute, Technical University of Denmark, Bulowsvej 27, 1790 Copenhagen V, Denmark
    J Clin Microbiol 46:3012-20. 2008
    ..Ten different phylotypes of Treponema were identified either by 16S rRNA gene sequencing of bacteria from DD lesions or by fluorescence in situ ..
  52. ncbi Phylogenetic foundation of spirochetes
    B J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Mol Microbiol Biotechnol 2:341-4. 2000
    ..Spirochaetaceae contains species of the genera Borrelia, Brevinema, Cristispira, Spirochaeta, Spironema, and Treponema. The second family Brachyspiraceae contains the genus Brachyspira (Serpulina)...
  53. ncbi Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease
    G R Riviere
    Department of Pediatric Dentistry, School of Dentistry, Oregon Health and Sciences University, Portland, OR 97201 3097, USA
    Oral Microbiol Immunol 17:113-8. 2002
    The purpose of this investigation was to use molecular and immunological techniques to determine whether oral Treponema infected the human brain...
  54. pmc Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, USA
    Infect Immun 72:6561-76. 2004
    b>Treponema paraluiscuniculi, the etiologic agent of rabbit venereal syphilis, is morphologically indistinguishable from Treponema pallidum subsp. pallidum (T...
  55. pmc Evaluation of LIAISON Treponema Screen, a novel recombinant antigen-based chemiluminescence immunoassay for laboratory diagnosis of syphilis
    Antonella Marangoni
    Microbiology Section, DMCSS, University of Bologna, Bologna, Italy
    Clin Diagn Lab Immunol 12:1231-4. 2005
    The purpose of this study was to evaluate the diagnostic performance of LIAISON Treponema Screen (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with that of rapid plasma reagin (RPR) and ..
  56. ncbi Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections
    Ryuta Kimizuka
    Department of Microbiology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba City, Chiba 261 8502, Japan
    Microbes Infect 5:1357-62. 2003
    ..The coexistence of P. gingivalis with Treponema denticola has been found at higher levels and proportions in periodontally diseased sites...
  57. ncbi Construction and analysis of hemin binding protein mutants in the oral pathogen Treponema denticola
    Xiaoping Xu
    Res Microbiol 153:569-77. 2002
    b>Treponema denticola, a periodontal pathogen, can use hemin as its sole iron source. The organism synthesizes two low-iron-induced outer-membrane hemin-binding proteins, HbpA and HbpB...
  58. ncbi PCR-based identification of Treponema maltophilum, T amylovorum, T medium, and T lecithinolyticum in primary root canal infections
    Jose F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ 20261, Brazil
    Arch Oral Biol 48:495-502. 2003
    ..The purpose of the present study was to investigate the occurrence of four treponemes-Treponema maltophilum, Treponema lecithinolyticum, Treponema amylovorum, and Treponema medium-in cases of primary ..
  59. pmc Treponema denticola is resistant to human beta-defensins
    Catherine A Brissette
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 70:3982-4. 2002
    Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human beta-defensin (h beta D) binding, we postulated that T...
  60. pmc Molecular typing of papillomatous digital dermatitis-associated Treponema isolates based on analysis of 16S-23S ribosomal DNA intergenic spacer regions
    L V Stamm
    Program in Infectious Diseases, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
    J Clin Microbiol 40:3463-9. 2002
    ..PDD-associated spirochetes have phenotypic characteristics consistent with members of the genus TREPONEMA: Partial 16S ribosomal DNA (rDNA) sequence analysis of clonal isolates from California cattle showed that they ..
  61. ncbi Role of Treponema denticola in periodontal diseases
    M N Sela
    Deportment of Oral Biology, Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel
    Crit Rev Oral Biol Med 12:399-413. 2001
    Among periodontal anaerobic pathogens, the oral spirochetes, and especially Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis...
  62. pmc Characterization of Treponema phagedenis-like spirochetes isolated from papillomatous digital dermatitis lesions in dairy cattle
    Darren J Trott
    School of Veterinary Science, The University of Queensland, St Lucia, Queensland, Australia
    J Clin Microbiol 41:2522-9. 2003
    ..These six strains shared an identical 16S ribosomal DNA sequence that was 98% similar to Treponema phagedenis and 99% similar to the uncultivated PDD spirochete sequence DDLK-4...
  63. ncbi Effects of a mixed infection with Porphyromonas gingivalis and Treponema denticola on abscess formation and immune responses in mice
    Masahiro Washizu
    Department of Microbiology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    Bull Tokyo Dent Coll 44:141-7. 2003
    Porphyromonas gingivalis and Treponema denticola have been found together in lesions of human periodontitis...
  64. pmc Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein
    Mohsen Amin
    CHIR Group in Matrix Dynamics and Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    Infect Immun 72:3650-4. 2004
    b>Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts...
  65. ncbi In situ structure of the complete Treponema primitia flagellar motor
    Gavin E Murphy
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:1062-4. 2006
    ..cryotomography of whole cells, the in situ structure of the complete flagellar motor from the spirochaete Treponema primitia at 7 nm resolution...
  66. ncbi Aerobic sulfide production and cadmium precipitation by Escherichia coli expressing the Treponema denticola cysteine desulfhydrase gene
    C L Wang
    Department of Chemical Engineering, University of California, Berkeley 94720-1462, USA
    Appl Microbiol Biotechnol 56:425-30. 2001
    The cysteine desulfhydrase gene of Treponema denticola was over-expressed in Escherichia coli to produce sulfide under aerobic conditions and to precipitate metal sulfide complexes on the cell wall...
  67. ncbi Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides
    C P Schultz
    Robert Koch Institut, D 13353 Berlin, Nordufer 20, Germany
    J Biol Chem 273:15661-6. 1998
    A new class of outer membrane lipid (OML) was isolated from the oral spirochete Treponema denticola strain ATCC 33521 using a phenol/chloroform/light petroleum procedure normally applied for lipopolysaccharide extraction...
  68. ncbi Degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from Porphyromonas gingivalis and Treponema denticola
    D Grenier
    Faculte de Medecine Dentaire, Universite Laval, Sainte Foy, Quebec, Canada
    Microbiology 142:955-61. 1996
    ..the ability of selected periodontopathogens, as well as two proteases isolated from Porphyromonas gingivalis and Treponema denticola, to degrade host protease inhibitors was evaluated...
  69. pmc Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola
    G Rosen
    Department of Oral Biology, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Infect Immun 67:1180-6. 1999
    We have recently demonstrated that the periodontopathogenic oral spirochete Treponema denticola possesses membrane-associated lipoproteins in addition to lipooligosaccharide (LOS)...
  70. pmc Genetic and structural analyses of cytoplasmic filaments of wild-type Treponema phagedenis and a flagellar filament-deficient mutant
    J Izard
    David Axelrod Institute for Public Health, Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    J Bacteriol 181:6739-46. 1999
    ..b>Treponema phagedenis cfpA was 2,037 nucleotides long, and the encoded polypeptide showed 78 to 100% amino acid sequence ..
  71. pmc Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment
    J C Fenno
    Department of Microbiology, University of British Columbia, Vancouver, Canada
    Infect Immun 68:1884-92. 2000
    Proteins secreted or exported by Treponema denticola have been implicated as mediators of specific interactions between the spirochete and subgingival tissues in periodontal diseases...
  72. ncbi TaqMan real-time polymerase chain reaction assay for the correlation of Treponema denticola numbers with the severity of periodontal disease
    A Yoshida
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    Oral Microbiol Immunol 19:196-200. 2004
    b>Treponema denticola has been implicated in periodontitis, and the presence of this organism in periodontal pockets has been investigated...
  73. pmc Characterization of a novel methyl-accepting chemotaxis gene, dmcB, from the oral spirochete Treponema denticola
    H Li
    Department of Oral Biology, State University of New York, Buffalo, New York 14214, USA
    Infect Immun 67:694-9. 1999
    Immediately downstream from the previously isolated Treponema denticola ATCC 35405 prtB gene coding for a chymotrypsinlike protease activity, an open reading frame, ORF3, was identified which shared significant homology with the highly ..
  74. pmc Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola
    Akihiko Ikegami
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, 14214, USA
    Infect Immun 72:4619-27. 2004
    ..protein, LrrA, that contains eight consensus tandem repeats of 23 amino acid residues, has been identified in Treponema denticola ATCC 35405...
  75. pmc Comparison of the biological responses induced by lipopolysaccharide and endotoxin of Treponema hyodysenteriae and Treponema innocens
    J M Greer
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames 50011
    Infect Immun 57:717-23. 1989
    ..activities of lipopolysaccharide (LPS; phenol-water) and endotoxin (butanol-water) preparations from virulent Treponema hyodysenteriae and avirulent Treponema innocens were examined. The LPS and endotoxin preparations from T...
  76. ncbi Immune response to Treponema pertenue and Treponema pallidum Nichols in patients with yaws
    P M Martin
    Institut Pasteur, Bangui
    Res Microbiol 141:181-6. 1990
    Human sera from African patients with acute yaws were analysed by Western blot (WB) against antigens of Treponema pallidum Nichols and two Treponema pertenue isolates...
  77. ncbi Polymerase chain reaction detection of Treponema denticola in endodontic infections within root canals
    J F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Int Endod J 34:280-4. 2001
    A 16S rDNA-based polymerase chain reaction (PCR) method was used to detect the occurrence of Treponema denticola in root canals.
  78. ncbi The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts
    Andre Paes Batista da Silva
    CIHR Group in Matrix Dynamics, University of Toronto, 124 Edward Street, Room 450, Toronto, Ontario, Canada M5G 1G6
    Cell Microbiol 6:485-98. 2004
    ..We examined a novel mechanism by which the major outer sheath protein (Msp) of the spirochaete Treponema denticola disrupts matrix remodelling mediated by intracellular digestion of collagen...
  79. pmc Cloning and expression of two novel hemin binding protein genes from Treponema denticola
    X Xu
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 69:4465-72. 2001
    b>Treponema denticola does not appear to produce siderophores, so it must acquire iron by other pathways. Indeed, T. denticola has been shown to have an iron-regulated 44-kDa outer membrane protein (HbpA) with hemin binding ability...
  80. ncbi A 43-kDa protein of Treponema denticola is essential for dentilisin activity
    Kazuyuki Ishihara
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    FEMS Microbiol Lett 232:181-8. 2004
    A protease of Treponema denticola, dentilisin, is thought to be part of a complex with 43- and 38-kDa proteins. A sequence encoding a 43-kDa protein was located in the 3' region of the prcA gene upstream of the dentilisin gene (prtP)...
  81. ncbi Treponema species associated with abscesses of endodontic origin
    J F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ, Brazil
    Oral Microbiol Immunol 19:336-9. 2004
    ..used the first polymerase chain reaction products to detect a specific fragment of the 16S rDNA of each Treponema species...
  82. ncbi Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family
    Jacques Izard
    The Forsyth Institute, Boston, MA 02115, USA
    J Mol Microbiol Biotechnol 11:159-66. 2006
    Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens...
  83. ncbi Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers
    Michihiro Narikiyo
    Genetics Division, National Cancer Center Research Institute and Department of Surgery, National Cancer Center Hospital, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:569-74. 2004
    ..Here we report the preferential and frequent infection of the oral periodontopathic spirochete Treponema denticola (T. denticola), Streptococcus mitis (S. mitis), and Streptococus anginosus (S...
  84. ncbi Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    FEMS Microbiol Lett 226:267-71. 2003
    b>Treponema denticola has been reported to coaggregate with Porphyromonas gingivalis and localize closely together in matured subgingival plaque. In this study of the interaction of T. denticola with P. gingivalis, the P...
  85. ncbi Intraoral dissemination of treponemes after periodontal therapy
    Benjamin Ehmke
    Department of Periodontology, Westfalian Wilhelm University, Waldeyerstrasse 30, 48149 Munster, Germany
    Clin Oral Investig 8:219-25. 2004
    ..After both therapies, possibly new infection with and/or dissemination of Treponema ssp. occurred, which led to treponemes recovering in different habitats and to increased intraoral prevalence...
  86. ncbi Distribution of periodontal pathogens in Korean aggressive periodontitis
    Jung Wook Lee
    Department of Periodontology, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 74:1329-35. 2003
    ..We undertook this study to determine the prevalence of seven putative periodontopathogens in Korean patients and to evaluate microbial differences in localized and generalized aggressive periodontitis patients...
  87. ncbi [Distribution of 3 kinds of periodontal pathogens in subgingival plaques of patients with chronic periodontitis]
    Xianhua Zhang
    Department of Periodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:287-8, 310. 2003
    To observe the prevalence of Porphyromonas gingivalis(Pg), Treponema denticola(Td) and Bacterides forsythus(Bf) subgingivally in diseased sites of chronic periodontitis (CP) patients.
  88. ncbi Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria
    Y Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    J Dent Res 84:456-61. 2005
    ..Here, we examined the effects of Treponema medium glycoconjugate on the activation of human gingival fibroblasts using phenol-water extracts from ..
  89. ncbi Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor
    Muneo Tanaka
    Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 6:1078-83. 2004
    ..including Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Prevotella nigrescens and Treponema denticola, was examined...
  90. ncbi Five-year maintenance follow-up of early-onset periodontitis patients
    Joanna J Kamma
    J Clin Periodontol 30:562-72. 2003
    ....
  91. ncbi Relationship between periodontal pocket sulfide levels and subgingival species
    G Torresyap
    Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
    J Clin Periodontol 30:1003-10. 2003
    ..This investigation examined the relationship between levels of sulfide and subgingival bacterial species in the same periodontal pockets...
  92. ncbi Subgingival microbiota of chilean patients with chronic periodontitis
    Nestor J Lopez
    Department of Conservative Dentistry, Section of Periodontics, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontol 75:717-25. 2004
    ..A study was undertaken to determine the characteristics of the subgingival microbiota of chronic periodontitis in Chileans residing in Santiago...
  93. ncbi Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population
    Yasuo Takeuchi
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontol 74:1460-9. 2003
    ..The aim of the present study was to investigate the prevalence of periodontopathic bacteria and to clarify the microbiological features of aggressive periodontitis in Japanese patients...
  94. ncbi Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: results after 12 months
    M Aimetti
    Department of Periodontology, University of Turin, Italy
    J Clin Periodontol 31:166-72. 2004
    ..The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions...
  95. ncbi Quadrant root planing versus same-day full-mouth root planing
    D A Apatzidou
    Periodontal and Oral Immunology Research Group, Glasgow Dental School, Glasgow, UK
    J Clin Periodontol 31:152-9. 2004
    ....
  96. ncbi Antigens of bacteria associated with periodontitis
    Neil M O'Brien-Simpson
    Centre for Oral Health Science, School of Dental Science, The University of Melbourne, Victoria, Australia
    Periodontol 2000 35:101-34. 2004
  97. ncbi Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes
    M Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Oral Microbiol Immunol 19:168-76. 2004
    ..six periodontal bacteria: Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans, Treponema denticola, Prevotella intermedia, and Prevotella nigrescens...
  98. pmc Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque [corrected] and in dental plaque samples
    Kazuyuki Ishihara
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan
    J Clin Microbiol 42:1313-5. 2004
    ..rRNA detection rates for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Treponema denticola, and Campylobacter rectus in samples of stenotic coronary artery plaques were determined to be 21...
  99. ncbi Occurrence of periodontal bacteria in healthy children: a 2-year longitudinal study
    Takashi Ooshima
    Department of Pediatric Dentistry, Osaka University, Graduate School of Dentistry, Yamada oka, Suita, Osaka, Japan
    Community Dent Oral Epidemiol 31:417-25. 2003
    ..To examine the occurrence of specific periodontal bacteria in children and adolescents...
  100. ncbi Clinical and microbiological associations in chronic periodontitis
    Allyson Nogueira Moreira
    Department of Periodontology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina
    Acta Odontol Latinoam 17:15-21. 2004
    ..Dark field microscopy was used to analyze the relative proportions of Treponema to the total microbial morphotypes...
  101. ncbi Changes in oral microbial profiles after periodontal treatment as determined by molecular analysis of 16S rRNA genes
    Mitsuo Sakamoto
    Japan Collection of Microorganisms, RIKEN, Wako, Saitama 351 0198, Japan
    J Med Microbiol 53:563-71. 2004
    ..6 %. The proportions of Tannerella forsythensis, Treponema denticola and Treponema socranskii were also markedly diminished after treatment...

Research Grants76

  1. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..detection and treatment of rare diseases, Syphilis is a chronic, multisystemic disease caused by the spirochete, Treponema pallidum subspecies pallidum (T. pallidum)...
  2. Crane - CheA and its Complexes
    BRIAN CRANE; Fiscal Year: 2009
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish ..
  3. Crane - CheA and its Complexes
    Brian R Crane; Fiscal Year: 2010
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish ..
  4. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    Ashu Sharma; Fiscal Year: 2009
    ..gingivalis), Treponema denticola and the main focus of this application, Tanerella forsythia (formerly Bacteroides forsythus)...
  5. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
    ..gingivalis), Treponema denticola and the main focus of this application, Tanerella forsythia (formerly Bacteroides forsythus)...
  6. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..Specific Aim 2. To determine if late colonizers such as P. gingivalis, Treponema denticola, and Tannerella forsythia antagonize quorum-sensing properties in S. mutans. i) S...
  7. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..Specific Aim 2. To determine if late colonizers such as P. gingivalis, Treponema denticola, and Tannerella forsythia antagonize quorum-sensing properties in S. mutans. i) S...
  8. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 1999
    ..in the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the ..
  9. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
    ..in the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the ..
  10. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2000
    ..in the genital tract including Chlamydia trachomatis (CT), herpes simplex virus (HSV), cytomegalovirus (CMV), Treponema pallidum, Haemophilus ducreyi, fungal infections and Neisseria gonorrhoeae (NG) and HPV infection and the ..
  11. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..Three bacterial species (Porphyromonas gingivalis, Treponema denticola, Bacteroides forsythus) have been shown to be closely associated with chronic periodontitis in humans, ..
  12. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2003
    ..Three bacterial species (Porphyromonas gingivalis, Treponema denticola, Bacteroides forsythus) have been shown to be closely associated with chronic periodontitis in humans, ..
  13. CULTIVABLE AND UNCULTIVABLE PERIODONTAL SPIROCHETES
    Floyd Dewhirst; Fiscal Year: 1992
    ..Currently, there are four known oral spirochete species: Treponema denticola, T. pectinovorum, T. socranskii, and T. vincentii...
  14. CULTIVABLE AND UNCULTIVABLE PERIODONTAL SPIROCHETES
    Floyd Dewhirst; Fiscal Year: 1993
    ..Currently, there are four known oral spirochete species: Treponema denticola, T. pectinovorum, T. socranskii, and T. vincentii...
  15. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2007
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  16. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2005
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  17. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  18. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    A Robert Neurath; Fiscal Year: 2004
    ..cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria associated with bacterial vaginosis; b) protects mice and rhesus monkeys against vaginal ..
  19. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
  20. PERIPLASMIC FLAGELLA OF TREPONEMA DENTICOLA
    John Ruby; Fiscal Year: 1993
    b>Treponema denticola is a member of the oral flora with its primary habitat being the gingival sulcus/periodontal pocket...
  21. PERIPLASMIC FLAGELLA OF TREPONEMA DENTICOLA
    John Ruby; Fiscal Year: 1990
    b>Treponema denticola is a member of the oral flora with its primary habitat being the gingival sulcus/periodontal pocket...
  22. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2001
    ..provided after submission indicates that two subtractive hybridization clones a) have homology to the Treponema denticola major outer surface protein (Msp); b) hybridize with multiple restriction fragments in T...
  23. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 1999
    ..provided after submission indicates that two subtractive hybridization clones a) have homology to the Treponema denticola major outer surface protein (Msp); b) hybridize with multiple restriction fragments in T...
  24. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2000
    ..provided after submission indicates that two subtractive hybridization clones a) have homology to the Treponema denticola major outer surface protein (Msp); b) hybridize with multiple restriction fragments in T...
  25. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    GEORGE ORDAL; Fiscal Year: 2009
    ..Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp., and Treponema pallidum have homologues to CheC, CheD, and CheV, genes first identified and then characterized in B. subtilis.
  26. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
  27. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..The application of genetic advancements and the availability of genomic sequences of Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp, are proving a wealth of new information...
  28. GENE ANALYSIS OF SPIROCHETE PERIPLASMIC FLAGELLA
    NYLES CHARON; Fiscal Year: 1999
    ..The model system being used is Serpulina hyodysenteriae, formally known as Treponema hyodysenteriae. S...
  29. Extracellular matrix adhesins of Treponema pallidum
    CAROLINE CAMERON; Fiscal Year: 2007
    Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  30. Extracellular matrix adhesins of Treponema pallidum
    CAROLINE CAMERON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  31. Extracellular matrix adhesins of Treponema pallidum
    Caroline E Cameron; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  32. BACTERIAL PROTEINASES IN PERIODONTAL DISEASE
    JAN S POTEMPA; Fiscal Year: 2010
    ..Gram-negative, anaerobic bacterial species, among which, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola constitute the so called "red complex" of microorganisms frequently associated with the development ..
  33. BACTERIAL PROTEINASES IN PERIODONTAL DISEASE
    Jan Potempa; Fiscal Year: 2009
    ..Gram-negative, anaerobic bacterial species, among which, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola constitute the so called "red complex" of microorganisms frequently associated with the development ..
  34. PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUM
    Steven Norris; Fiscal Year: 1990
    b>Treponema pallidum subsp. pallidum and related organisms are helically- shaped bacteria which cause venereal syphilis, endemic syphilis, yaws and pinta in humans...
  35. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
  36. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 1993
    ..abstract): Spirochetes are a unique and diverse group of helical-shaped bacteria that include the pathogens Treponema pallidum (syphilis) and Borrelia burgdorferi (Lyme disease)...
  37. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 1999
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Treponema denticola and Prevotella intermedia...
  38. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2006
    ..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
  39. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2000
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Treponema denticola and Prevotella intermedia...
  40. GENETICS OF TREPONEMA PALLIDUM PATHOGENICITY
    Michael Lovett; Fiscal Year: 1991
    There has been recent progress in understanding the molecular basis of two key aspects of the immunobiology of Treponema pallidum, the antigenic inertness of its surface, and its resistance to killing by immune mechanisms...
  41. Antigenic Variation of TprK in Treponema pallidum
    Sheila A Lukehart; Fiscal Year: 2010
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  42. Antigenic Variation of TprK in Treponema pallidum
    Sheila Lukehart; Fiscal Year: 2009
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  43. Antigenic Variation of TprK in Treponema pallidum
    Sheila A Lukehart; Fiscal Year: 2010
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  44. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2001
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (Treponema ..
  45. SEQUENCING OF THE HAEMOPHILUS DUCREYI GENOME
    Robert Munson; Fiscal Year: 1999
    ..a integrated data base with detailed annotation of sequences from sexually transmitted pathogens including Treponema pallidum, Neisseria gonorrhoeae and Chlamydia trachomatis...
  46. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2001
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  47. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2003
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  48. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2002
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  49. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2004
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  50. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2005
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  51. QUORUM SENSING AND PERIODONTAL PATHOGENS
    Luciano Passador; Fiscal Year: 1999
    ..The involvement of specific gram negative bacteria such as Prevotella intermedia, Porphyromonas gingivalis, Treponema denticola, and Actinobacillus actinomycetemcomitans, and the role of some of the specific virulence factors they ..
  52. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 1999
    ..However, the recent publication of the genomic sequences for Borrelia burgdorferi and Treponema pallidum, and a newly initiated project for sequencing the Treponema denticola genome, provide a wealth of new ..
  53. Treponema pallidum: Pathogenesis-associated molecules
    Sheila A Lukehart; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  54. Role of Zonula Occludens Toxin in the Pathogenesis of Treponema denticola
    Chunhao Li; Fiscal Year: 2009
    ..Both clinical and basic studies have shown that the oral spirochete Treponema denticola (Td) is strongly associated with human periodontal and endodontic diseases, such as acute necrotizing ..
  55. Treponema pallidum: Pathogenesis-associated molecules
    Sheila Lukehart; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  56. Treponema pallidum:Pathogenesis-associated molecules
    Sheila Lukehart; Fiscal Year: 2007
    Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  57. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 2000
    ..However, the recent publication of the genomic sequences for Borrelia burgdorferi and Treponema pallidum, and a newly initiated project for sequencing the Treponema denticola genome, provide a wealth of new ..
  58. Treponema pallidum: Pathogenesis-associated molecules
    Sheila Lukehart; Fiscal Year: 2006
    Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  59. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 1999
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  60. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  61. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2002
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  62. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2001
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  63. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2000
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  64. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    b>Treponema denticola is an important member of a consortium of microorganisms that are etiologic in the initiation and progression of periodontitis...
  65. IMMUNE MECHANISMS IN EXPERIMENTAL SYPHILIS
    Michael Lovett; Fiscal Year: 1999
    ..in experimental syphilis has been limited by the fact that the rare outer membrane spanning proteins (TROMP) of Treponema pallidum had not been defined. This proposal is based on isolation of the T...
  66. IMMUNOGENS OF T PALLIDUM: IDENTIFICATION AND FUNCTION
    Sheila Lukehart; Fiscal Year: 1990
    ..Although a number of Treponema pallidum antigens have been identified and characterized in terms of antibody reactivity, little is known about ..
  67. A Novel Approach to the Development of a Syphilis Vaccine Using Rabbit Monoclonal
    James Miller; Fiscal Year: 2009
    ..The focus of this proposal is the isolation of rabbit monoclonal antibodies directed against Treponema pallidum surface antigens that are targets of treponemicidal activity...