treponema

Summary

Summary: A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man.

Top Publications

  1. ncbi The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis
    Kristin N Harper
    Department of Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
    FEMS Immunol Med Microbiol 53:322-32. 2008
  2. ncbi Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 6:e20415. 2011
  3. ncbi Characterization of novel bovine gastrointestinal tract Treponema isolates and comparison with bovine digital dermatitis treponemes
    Nicholas J Evans
    School of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    Appl Environ Microbiol 77:138-47. 2011
  4. ncbi Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A
    Michal Strouhal
    Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    Infect Immun 75:5859-66. 2007
  5. ncbi Phylogenetic foundation of spirochetes
    B J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Mol Microbiol Biotechnol 2:341-4. 2000
  6. ncbi Identification of a novel, invasive, not-yet-cultivated Treponema sp. in the large intestine of pigs by PCR amplification of the 16S rRNA gene
    Lars Mølbak
    Danish Institute for Food and Veterinary Research, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    J Clin Microbiol 44:4537-40. 2006
  7. ncbi Activation of matrix metalloproteinase-2 by a novel oral spirochetal species Treponema lecithinolyticum
    B K Choi
    Department of Oral Biology, College of Dentistry and Brain Korea 21 Project of Medical Sciences, Yonsei University, Seoul
    J Periodontol 72:1594-600. 2001
  8. ncbi Treponema denticola cystalysin catalyzes beta-desulfination of L-cysteine sulfinic acid and beta-decarboxylation of L-aspartate and oxalacetate
    Barbara Cellini
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    FEBS Lett 554:306-10. 2003
  9. ncbi Adherence of human oral spirochetes by collagen-binding proteins
    T Umemoto
    Department of Oral Microbiology, School of Dentistry, Asahi University, Gifu, Japan
    Microbiol Immunol 41:917-23. 1997
  10. ncbi Evidence of multiple Treponema phylotypes involved in bovine digital dermatitis as shown by 16S rRNA gene analysis and fluorescence in situ hybridization
    Kirstine Klitgaard
    National Veterinary Institute, Technical University of Denmark, Bulowsvej 27, 1790 Copenhagen V, Denmark
    J Clin Microbiol 46:3012-20. 2008

Research Grants

  1. Crane - CheA and its Complexes
    BRIAN CRANE; Fiscal Year: 2009
  2. Crane - CheA and its Complexes
    Brian R Crane; Fiscal Year: 2010
  3. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
  4. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
  5. CULTIVABLE AND UNCULTIVABLE PERIODONTAL SPIROCHETES
    Floyd Dewhirst; Fiscal Year: 1993
  6. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2001
  7. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    GEORGE ORDAL; Fiscal Year: 2009
  8. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
  9. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
  10. Extracellular matrix adhesins of Treponema pallidum
    CAROLINE CAMERON; Fiscal Year: 2009

Detail Information

Publications193 found, 100 shown here

  1. ncbi The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis
    Kristin N Harper
    Department of Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
    FEMS Immunol Med Microbiol 53:322-32. 2008
    Despite the completion of the Treponema pallidum genome project, only minor genetic differences have been found between the subspecies that cause venereal syphilis (ssp. pallidum) and the nonvenereal diseases yaws (ssp...
  2. ncbi Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 6:e20415. 2011
    b>Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis...
  3. ncbi Characterization of novel bovine gastrointestinal tract Treponema isolates and comparison with bovine digital dermatitis treponemes
    Nicholas J Evans
    School of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    Appl Environ Microbiol 77:138-47. 2011
    ..obtained from the bovine GI tract, which, on the basis of 16S rRNA gene comparisons, clustered within the genus Treponema as four novel phylotypes...
  4. ncbi Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A
    Michal Strouhal
    Department of Biology, Building A6, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
    Infect Immun 75:5859-66. 2007
    The genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp...
  5. ncbi Phylogenetic foundation of spirochetes
    B J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Mol Microbiol Biotechnol 2:341-4. 2000
    ..Spirochaetaceae contains species of the genera Borrelia, Brevinema, Cristispira, Spirochaeta, Spironema, and Treponema. The second family Brachyspiraceae contains the genus Brachyspira (Serpulina)...
  6. ncbi Identification of a novel, invasive, not-yet-cultivated Treponema sp. in the large intestine of pigs by PCR amplification of the 16S rRNA gene
    Lars Mølbak
    Danish Institute for Food and Veterinary Research, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    J Clin Microbiol 44:4537-40. 2006
    ..The 16S rRNA gene was PCR amplified, and the closest related type strain was Treponema bryantiiT (90.1%)...
  7. ncbi Activation of matrix metalloproteinase-2 by a novel oral spirochetal species Treponema lecithinolyticum
    B K Choi
    Department of Oral Biology, College of Dentistry and Brain Korea 21 Project of Medical Sciences, Yonsei University, Seoul
    J Periodontol 72:1594-600. 2001
    ..In order to elucidate the etiologic role of oral spirochetes, we investigated the effects of Treponema lecithinolyticum, a novel saccharolytic species, on MMP-2 activation...
  8. ncbi Treponema denticola cystalysin catalyzes beta-desulfination of L-cysteine sulfinic acid and beta-decarboxylation of L-aspartate and oxalacetate
    Barbara Cellini
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    FEBS Lett 554:306-10. 2003
    Pyridoxal 5'-phosphate-dependent cystalysin from Treponema denticola catalyzes the beta-displacement of the beta-substituent from both L-aspartate and L-cysteine sulfinic acid...
  9. ncbi Adherence of human oral spirochetes by collagen-binding proteins
    T Umemoto
    Department of Oral Microbiology, School of Dentistry, Asahi University, Gifu, Japan
    Microbiol Immunol 41:917-23. 1997
    ..IV-, and V-collagen-binding polypeptides (CBPs) were detected in the heated and unheated preparations from both Treponema denticola ATCC 33520 and T. socranskii subsp. buccale ATCC 35534...
  10. ncbi Evidence of multiple Treponema phylotypes involved in bovine digital dermatitis as shown by 16S rRNA gene analysis and fluorescence in situ hybridization
    Kirstine Klitgaard
    National Veterinary Institute, Technical University of Denmark, Bulowsvej 27, 1790 Copenhagen V, Denmark
    J Clin Microbiol 46:3012-20. 2008
    ..Ten different phylotypes of Treponema were identified either by 16S rRNA gene sequencing of bacteria from DD lesions or by fluorescence in situ ..
  11. ncbi Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the first spirochetes isolated from termite guts
    Joseph R Graber
    Department of Microbiology and Molecular Genetics and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824-4320, USA
    Appl Environ Microbiol 70:1315-20. 2004
    ..A. Breznak, Science 292:2495-2498, 2001). However, application of specific epithets to the strains isolated (Treponema strains ZAS-1, ZAS-2, and ZAS-9) was postponed pending a more complete characterization of their phenotypic ..
  12. ncbi Prevalence of bovine papillomavirus and Treponema DNA in bovine digital dermatitis lesions
    Sabine Brandt
    Equine Biotechnology Unit, Equine Clinic, Veterinary University Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Vet Microbiol 148:161-7. 2011
    ..intact skin from 8 BDD-affected and 33 healthy cows were assessed for the presence of bovine papillomavirus and Treponema DNA...
  13. ncbi Genetic relatedness and phenotypic characteristics of Treponema associated with human periodontal tissues and ruminant foot disease
    Andrew M Edwards
    Oral Microbiology Unit, Department of Oral and Dental Science, University of Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK
    Microbiology 149:1083-93. 2003
    b>Treponema have been implicated recently in the pathogenesis of digital dermatitis (DD) and contagious ovine digital dermatitis (CODD) that are infectious diseases of bovine and ovine foot tissues, respectively...
  14. ncbi Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola
    J C Fenno
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Bacteriol 178:2489-97. 1996
    The gene encoding the major outer sheath protein (Msp) of the oral spirochete Treponema denticola ATCC 35405 was cloned, sequenced, and expressed in Escherichia coli...
  15. ncbi Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, USA
    Infect Immun 72:6561-76. 2004
    b>Treponema paraluiscuniculi, the etiologic agent of rabbit venereal syphilis, is morphologically indistinguishable from Treponema pallidum subsp. pallidum (T...
  16. ncbi Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
    We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T...
  17. ncbi Evaluation of LIAISON Treponema Screen, a novel recombinant antigen-based chemiluminescence immunoassay for laboratory diagnosis of syphilis
    Antonella Marangoni
    Microbiology Section, DMCSS, University of Bologna, Bologna, Italy
    Clin Diagn Lab Immunol 12:1231-4. 2005
    The purpose of this study was to evaluate the diagnostic performance of LIAISON Treponema Screen (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with that of rapid plasma reagin (RPR) and ..
  18. ncbi Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola
    G Rosen
    Department of Oral Biology, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Infect Immun 67:1180-6. 1999
    We have recently demonstrated that the periodontopathogenic oral spirochete Treponema denticola possesses membrane-associated lipoproteins in addition to lipooligosaccharide (LOS)...
  19. ncbi Characterization of a novel methyl-accepting chemotaxis gene, dmcB, from the oral spirochete Treponema denticola
    H Li
    Department of Oral Biology, State University of New York, Buffalo, New York 14214, USA
    Infect Immun 67:694-9. 1999
    Immediately downstream from the previously isolated Treponema denticola ATCC 35405 prtB gene coding for a chymotrypsinlike protease activity, an open reading frame, ORF3, was identified which shared significant homology with the highly ..
  20. ncbi Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides
    C P Schultz
    Robert Koch Institut, D 13353 Berlin, Nordufer 20, Germany
    J Biol Chem 273:15661-6. 1998
    A new class of outer membrane lipid (OML) was isolated from the oral spirochete Treponema denticola strain ATCC 33521 using a phenol/chloroform/light petroleum procedure normally applied for lipopolysaccharide extraction...
  21. ncbi Treponema species associated with abscesses of endodontic origin
    J F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ, Brazil
    Oral Microbiol Immunol 19:336-9. 2004
    ..used the first polymerase chain reaction products to detect a specific fragment of the 16S rDNA of each Treponema species...
  22. ncbi Genetic and structural analyses of cytoplasmic filaments of wild-type Treponema phagedenis and a flagellar filament-deficient mutant
    J Izard
    David Axelrod Institute for Public Health, Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    J Bacteriol 181:6739-46. 1999
    ..b>Treponema phagedenis cfpA was 2,037 nucleotides long, and the encoded polypeptide showed 78 to 100% amino acid sequence ..
  23. ncbi Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment
    J C Fenno
    Department of Microbiology, University of British Columbia, Vancouver, Canada
    Infect Immun 68:1884-92. 2000
    Proteins secreted or exported by Treponema denticola have been implicated as mediators of specific interactions between the spirochete and subgingival tissues in periodontal diseases...
  24. ncbi Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola
    Akihiko Ikegami
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, 14214, USA
    Infect Immun 72:4619-27. 2004
    ..protein, LrrA, that contains eight consensus tandem repeats of 23 amino acid residues, has been identified in Treponema denticola ATCC 35405...
  25. ncbi Aerobic sulfide production and cadmium precipitation by Escherichia coli expressing the Treponema denticola cysteine desulfhydrase gene
    C L Wang
    Department of Chemical Engineering, University of California, Berkeley 94720-1462, USA
    Appl Microbiol Biotechnol 56:425-30. 2001
    The cysteine desulfhydrase gene of Treponema denticola was over-expressed in Escherichia coli to produce sulfide under aerobic conditions and to precipitate metal sulfide complexes on the cell wall...
  26. ncbi Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola
    R Lux
    School of Dentistry and Molecular Biology Institute, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095-1668, USA
    Infect Immun 69:6276-83. 2001
    ..the role of motility and chemotaxis in tissue penetration by the periodontal disease-associated oral spirochete Treponema denticola using an oral epithelial cell line-based experimental approach. Wild-type T...
  27. ncbi Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein
    Mohsen Amin
    CHIR Group in Matrix Dynamics and Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    Infect Immun 72:3650-4. 2004
    b>Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts...
  28. ncbi Polymerase chain reaction detection of Treponema denticola in endodontic infections within root canals
    J F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Int Endod J 34:280-4. 2001
    A 16S rDNA-based polymerase chain reaction (PCR) method was used to detect the occurrence of Treponema denticola in root canals.
  29. ncbi Cloning and expression of two novel hemin binding protein genes from Treponema denticola
    X Xu
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 69:4465-72. 2001
    b>Treponema denticola does not appear to produce siderophores, so it must acquire iron by other pathways. Indeed, T. denticola has been shown to have an iron-regulated 44-kDa outer membrane protein (HbpA) with hemin binding ability...
  30. ncbi PCR-based identification of Treponema maltophilum, T amylovorum, T medium, and T lecithinolyticum in primary root canal infections
    Jose F Siqueira
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ 20261, Brazil
    Arch Oral Biol 48:495-502. 2003
    ..The purpose of the present study was to investigate the occurrence of four treponemes-Treponema maltophilum, Treponema lecithinolyticum, Treponema amylovorum, and Treponema medium-in cases of primary ..
  31. ncbi Role of Treponema denticola in periodontal diseases
    M N Sela
    Deportment of Oral Biology, Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel
    Crit Rev Oral Biol Med 12:399-413. 2001
    Among periodontal anaerobic pathogens, the oral spirochetes, and especially Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis...
  32. ncbi Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp
    J C Fenno
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Bacteriol 179:1082-9. 1997
    The major surface protein (Msp) of Treponema denticola has been implicated as a mediator of the interaction between the spirochete and the gingival epithelium in periodontal diseases. Previous studies showed that the Msp of T...
  33. ncbi Degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from Porphyromonas gingivalis and Treponema denticola
    D Grenier
    Faculte de Medecine Dentaire, Universite Laval, Sainte Foy, Quebec, Canada
    Microbiology 142:955-61. 1996
    ..the ability of selected periodontopathogens, as well as two proteases isolated from Porphyromonas gingivalis and Treponema denticola, to degrade host protease inhibitors was evaluated...
  34. ncbi A 43-kDa protein of Treponema denticola is essential for dentilisin activity
    Kazuyuki Ishihara
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    FEMS Microbiol Lett 232:181-8. 2004
    A protease of Treponema denticola, dentilisin, is thought to be part of a complex with 43- and 38-kDa proteins. A sequence encoding a 43-kDa protein was located in the 3' region of the prcA gene upstream of the dentilisin gene (prtP)...
  35. ncbi Effects of a mixed infection with Porphyromonas gingivalis and Treponema denticola on abscess formation and immune responses in mice
    Masahiro Washizu
    Department of Microbiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan
    Bull Tokyo Dent Coll 44:141-7. 2003
    Porphyromonas gingivalis and Treponema denticola have been found together in lesions of human periodontitis...
  36. ncbi Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections
    Ryuta Kimizuka
    Department of Microbiology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba City, Chiba 261 8502, Japan
    Microbes Infect 5:1357-62. 2003
    ..The coexistence of P. gingivalis with Treponema denticola has been found at higher levels and proportions in periodontally diseased sites...
  37. ncbi The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts
    Andre Paes Batista da Silva
    CIHR Group in Matrix Dynamics, University of Toronto, 124 Edward Street, Room 450, Toronto, Ontario, Canada M5G 1G6
    Cell Microbiol 6:485-98. 2004
    ..We examined a novel mechanism by which the major outer sheath protein (Msp) of the spirochaete Treponema denticola disrupts matrix remodelling mediated by intracellular digestion of collagen...
  38. ncbi Comparison of the biological responses induced by lipopolysaccharide and endotoxin of Treponema hyodysenteriae and Treponema innocens
    J M Greer
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames 50011
    Infect Immun 57:717-23. 1989
    ..activities of lipopolysaccharide (LPS; phenol-water) and endotoxin (butanol-water) preparations from virulent Treponema hyodysenteriae and avirulent Treponema innocens were examined. The LPS and endotoxin preparations from T...
  39. ncbi Immune response to Treponema pertenue and Treponema pallidum Nichols in patients with yaws
    P M Martin
    Institut Pasteur, Bangui
    Res Microbiol 141:181-6. 1990
    Human sera from African patients with acute yaws were analysed by Western blot (WB) against antigens of Treponema pallidum Nichols and two Treponema pertenue isolates...
  40. ncbi In situ structure of the complete Treponema primitia flagellar motor
    Gavin E Murphy
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:1062-4. 2006
    ..cryotomography of whole cells, the in situ structure of the complete flagellar motor from the spirochaete Treponema primitia at 7 nm resolution...
  41. ncbi Characterization of Treponema phagedenis-like spirochetes isolated from papillomatous digital dermatitis lesions in dairy cattle
    Darren J Trott
    School of Veterinary Science, The University of Queensland, St Lucia, Queensland, Australia
    J Clin Microbiol 41:2522-9. 2003
    ..These six strains shared an identical 16S ribosomal DNA sequence that was 98% similar to Treponema phagedenis and 99% similar to the uncultivated PDD spirochete sequence DDLK-4...
  42. ncbi Construction and analysis of hemin binding protein mutants in the oral pathogen Treponema denticola
    Xiaoping Xu
    Res Microbiol 153:569-77. 2002
    b>Treponema denticola, a periodontal pathogen, can use hemin as its sole iron source. The organism synthesizes two low-iron-induced outer-membrane hemin-binding proteins, HbpA and HbpB...
  43. ncbi Molecular typing of papillomatous digital dermatitis-associated Treponema isolates based on analysis of 16S-23S ribosomal DNA intergenic spacer regions
    L V Stamm
    Program in Infectious Diseases, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
    J Clin Microbiol 40:3463-9. 2002
    ..PDD-associated spirochetes have phenotypic characteristics consistent with members of the genus TREPONEMA: Partial 16S ribosomal DNA (rDNA) sequence analysis of clonal isolates from California cattle showed that they ..
  44. ncbi Treponema denticola is resistant to human beta-defensins
    Catherine A Brissette
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 70:3982-4. 2002
    Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human beta-defensin (h beta D) binding, we postulated that T...
  45. ncbi TaqMan real-time polymerase chain reaction assay for the correlation of Treponema denticola numbers with the severity of periodontal disease
    A Yoshida
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    Oral Microbiol Immunol 19:196-200. 2004
    b>Treponema denticola has been implicated in periodontitis, and the presence of this organism in periodontal pockets has been investigated...
  46. ncbi Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family
    Jacques Izard
    The Forsyth Institute, Boston, MA 02115, USA
    J Mol Microbiol Biotechnol 11:159-66. 2006
    Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens...
  47. ncbi Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease
    G R Riviere
    Department of Pediatric Dentistry, School of Dentistry, Oregon Health and Sciences University, Portland, OR 97201-3097, USA
    Oral Microbiol Immunol 17:113-8. 2002
    The purpose of this investigation was to use molecular and immunological techniques to determine whether oral Treponema infected the human brain...
  48. ncbi Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers
    Michihiro Narikiyo
    Genetics Division, National Cancer Center Research Institute and Department of Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
    Cancer Sci 95:569-74. 2004
    ..Here we report the preferential and frequent infection of the oral periodontopathic spirochete Treponema denticola (T. denticola), Streptococcus mitis (S. mitis), and Streptococus anginosus (S...
  49. ncbi Physiology and nutrition of Treponema primitia, an H2/CO2-acetogenic spirochete from termite hindguts
    Joseph R Graber
    Department of Microbiology and Molecular Genetics and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA
    Appl Environ Microbiol 70:1307-14. 2004
    b>Treponema primitia strains ZAS-1 and ZAS-2, the first spirochetes to be isolated from termite hindguts (J. R. Leadbetter, T. M. Schmidt, J. R. Graber, and J. A...
  50. ncbi Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan
    FEMS Microbiol Lett 226:267-71. 2003
    b>Treponema denticola has been reported to coaggregate with Porphyromonas gingivalis and localize closely together in matured subgingival plaque. In this study of the interaction of T. denticola with P. gingivalis, the P...
  51. ncbi Comparison of the benzoyl-DL-arginine-naphthylamide (BANA) test, DNA probes, and immunological reagents for ability to detect anaerobic periodontal infections due to Porphyromonas gingivalis, Treponema denticola, and Bacteroides forsythus
    W J Loesche
    Department of Biological and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Clin Microbiol 30:427-33. 1992
    ..of periodontal disease are associated with the presence or overgrowth of anaerobic species that could include Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus among others...
  52. ncbi Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
    B Opitz
    , , Humboldt-University, 10117 Berlin, Germany
    J Biol Chem 276:22041-7. 2001
    ..Glycolipids from Treponema maltophilum and Treponema brennaborense, as well as highly purified LTAs from Staphylococcus aureus and Bacillus ..
  53. ncbi Antagonistic effect of oral bacteria towards Treponema denticola
    D Grenier
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec, Canada
    J Clin Microbiol 34:1249-52. 1996
    This study was designed to isolate oral bacteria exhibiting antagonism towards Treponema denticola and to characterize the inhibitory activity...
  54. ncbi Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene family
    L V Stamm
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    FEMS Microbiol Lett 169:155-63. 1998
    TnphoA mutagenesis was used to identify genes encoding exported proteins in a genomic DNA library of Treponema pallidum, the syphilis agent...
  55. ncbi Quadrant root planing versus same-day full-mouth root planing
    D A Apatzidou
    Periodontal and Oral Immunology Research Group, Glasgow Dental School, Glasgow, UK
    J Clin Periodontol 31:152-9. 2004
    ..periodontal pathogens: Porphyromonas gingivalis; Actinobacillus actinomycetemcomitans; Prevotella intermedia; Treponema denticola and Bacteroides forsythus...
  56. ncbi Periodontal microbiota and clinical periodontal status in a rural sample in southern Thailand
    P N Papapanou
    Columbia University School of Dental and Oral Surgery, NY, USA
    Eur J Oral Sci 110:345-52. 2002
    ....
  57. ncbi Oral treponemes in primary root canal infections as detected by nested PCR
    I N Rôças
    Department of Endodontics, Faculty of Dentistry, Estacio de Sa University, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Int Endod J 36:20-6. 2003
    To investigate the prevalences of four Treponema species in primary root canal infections using a nested PCR assay.
  58. ncbi Antigens of bacteria associated with periodontitis
    Paul D Veith
    Centre for Oral Health Science, School of Dental Science, The University of Melbourne, Victoria, Australia
    Periodontol 2000 35:101-34. 2004
  59. ncbi The relationship of oral malodor in patients with or without periodontal disease
    Luciene Cristina Figueiredo
    Paulista University, Department of Health Sciences, , , Brazil
    J Periodontol 73:1338-42. 2002
    ..there is some relationship between the presence of N-benzoyl-DL-arginine-2-napthylamide (BANA)-positive species Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus and clinical and oral malodor parameters...
  60. ncbi Configural frequency analysis for exploring bacterial sets in periodontal health and disease
    M E Cohen
    Naval Dental Research Institute, Great Lakes, Illinois 60088-5259
    Community Dent Oral Epidemiol 21:283-7. 1993
    ..In the first, the occurrence of Bacteroides (Porphyromonas) gingivalis (Bg) and Treponema denticola (Td) was studied in military subjects...
  61. ncbi Subgingival and tongue microbiota during early periodontitis
    A C R Tanner
    Department of Molecular Genetics, The Forsyth Institute, Boston, MA 02115, USA
    J Dent Res 85:318-23. 2006
    ..Detection of periodontal pathogens in early periodontitis suggests an etiology similar to that of more advanced disease...
  62. ncbi Microbial complexes detected in the second/third molar region in patients with asymptomatic third molars
    Raymond P White
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 60:1234-40. 2002
    ..Our goal was to report the detection and levels of pathogenic bacteria in subgingival plaque samples taken from the distal of all second molars in 295 patients with asymptomatic third molars...
  63. ncbi Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions
    Shinichi Sumida
    Department of Removable Partial Prosthodontics, Tokyo Dental College, Japan
    Int J Oral Maxillofac Implants 17:696-702. 2002
    ..gingivalis, Prevotella intermedia, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Treponema denticola were 80.0%, 53.3%, 46.7%, 60.0% and 40.0%, respectively...
  64. ncbi Comparison of microbial cultivation and a commercial PCR based method for detection of periodontopathogenic species in subgingival plaque samples
    Sigrun Eick
    Department of Microbiological Microbiology, University Hospital of Jena, Germany
    J Clin Periodontol 29:638-44. 2002
    ..The purpose of this study was to validate the commercially available micro-Dent(R) test which employs probes for A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus and T. denticola...
  65. ncbi Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis
    L J Jin
    Faculty of Dentistry, University of Hong Kong, Hong Kong
    J Clin Periodontol 29:604-14. 2002
    ....
  66. ncbi Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth
    H Yamada
    Department of Periodontology and Endodontology, Okayama University Dental School, Okayama, Japan
    J Int Acad Periodontol 3:42-7. 2001
    ....
  67. ncbi Molecular epidemiology of oral treponemes in patients with periodontitis and in periodontitis-resistant subjects
    Annette Moter
    Institut für Mikrobiologie und Hygiene, Charite Universitatsmedizin Berlin, Dorotheen Str 96, D 10117 Berlin, Germany
    J Clin Microbiol 44:3078-85. 2006
    ..This difference was pronounced for treponemes of the phylogenetic groups II and IV and for Treponema socranskii and Treponema lecithinolyticum...
  68. ncbi Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque [corrected] and in dental plaque samples
    Kazuyuki Ishihara
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan
    J Clin Microbiol 42:1313-5. 2004
    ..rRNA detection rates for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Treponema denticola, and Campylobacter rectus in samples of stenotic coronary artery plaques were determined to be 21...
  69. ncbi Occurrence of periodontal bacteria in healthy children: a 2-year longitudinal study
    Takashi Ooshima
    Department of Pediatric Dentistry, Osaka University, Graduate School of Dentistry, Yamada oka, Suita, Osaka, Japan
    Community Dent Oral Epidemiol 31:417-25. 2003
    ..To examine the occurrence of specific periodontal bacteria in children and adolescents...
  70. ncbi Relationship between periodontal pocket sulfide levels and subgingival species
    G Torresyap
    Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
    J Clin Periodontol 30:1003-10. 2003
    ..This investigation examined the relationship between levels of sulfide and subgingival bacterial species in the same periodontal pockets...
  71. ncbi Quadrant root planing versus same-day full-mouth root planing. II. Microbiological findings
    D A Apatzidou
    Periodontal and Oral Immunology Research Group, Glasgow Dental School, Glasgow, UK
    J Clin Periodontol 31:141-8. 2004
    ..determine the presence of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Treponema denticola and Bacteroides forsythus in plaque...
  72. ncbi Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population
    Yasuo Takeuchi
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontol 74:1460-9. 2003
    ..gingivalis, and Treponema denticola were frequently detected in localized as well as generalized aggressive periodontitis patients...
  73. ncbi Association of Treponema spp. with canine periodontitis
    Marcel Nordhoff
    Institut für Mikrobiologie und Tierseuchen, FU Berlin, Germany
    Vet Microbiol 127:334-42. 2008
    To evaluate the association of oral Treponema (T.) spp. with severity of canine periodontitis, subgingival plaque samples of dogs of various breeds undergoing surgery were investigated. A wide range of oral Treponema spp...
  74. ncbi Distribution of periodontal pathogens in Korean aggressive periodontitis
    Jung-Wook Lee
    Department of Periodontology, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 74:1329-35. 2003
    ..8% for Porphyromonas gingivalis, 78.8% for Prevotella intermedia, and 96.8% for Treponema sp. The prevalences of these bacteria were significantly higher in diseased sites than in healthy sites...
  75. ncbi Comparison of 16S rDNA-based PCR and checkerboard DNA-DNA hybridisation for detection of selected endodontic pathogens
    Jose F Siqueira
    Institute of Microbiology, Prof Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Med Microbiol 51:1090-6. 2002
    ..gingivalis and Treponema denticola directly from clinical samples...
  76. ncbi [Distribution of 3 kinds of periodontal pathogens in subgingival plaques of patients with chronic periodontitis]
    Xianhua Zhang
    Department of Periodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:287-8, 310. 2003
    OBJECTIVE: To observe the prevalence of Porphyromonas gingivalis(Pg), Treponema denticola(Td) and Bacterides forsythus(Bf) subgingivally in diseased sites of chronic periodontitis (CP) patients...
  77. ncbi Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: results after 12 months
    M Aimetti
    Department of Periodontology, University of Turin, Italy
    J Clin Periodontol 31:166-72. 2004
    ..The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions...
  78. ncbi Genomics of oral bacteria
    Margaret J Duncan
    Department of Molecular Genetics, The Forsyth Institute, 140 Fenway, Boston, MA 02115, USA
    Crit Rev Oral Biol Med 14:175-87. 2003
    ..The oral microbiota is a unique community especially suited for new challenges to sequence the metagenomes of microbial consortia, and the genomes of uncultivable bacteria...
  79. ncbi Five-year maintenance follow-up of early-onset periodontitis patients
    Joanna J Kamma
    J Clin Periodontol 30:562-72. 2003
    ....
  80. ncbi Clinical and microbiological analysis of periodontally diseased sites after renal transplant
    Mara L S O Vieira
    School of Dentistry, , , Brazil
    Spec Care Dentist 22:115-20. 2002
    ..Subgingival plaque samples were analyzed for the presence of Porphyromonas gingivalis, Treponema denticola and/or Bacteroides forsythus using the BANA test...
  81. ncbi Subgingival microbial profiles in refractory periodontal disease
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
    J Clin Periodontol 29:260-8. 2002
    ..CONCLUSIONS: 4 subgingival microbial profiles were detected among refractory subjects. "Refractory microbial profiles" could be detected in subjects who had not yet exhibited refractory disease...
  82. ncbi The localization of periodontal-disease-associated bacteria in human periodontal pockets
    Y Noiri
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Suita, Japan
    J Dent Res 80:1930-4. 2001
    ..In the middle and deep pocket zones, Fusobacterium nucleatum and Treponema denticola were especially localized in the unattached plaque area, but Eikenella corrodens was observed in the ..
  83. ncbi Efficacy of manual and powered toothbrushes (II). Effect on microbiological parameters
    A D Haffajee
    Department of Periodontology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115-3799, USA
    J Clin Periodontol 28:947-54. 2001
    ..Mean prevalence was decreased more for Porphyromonas gingivalis, Campylobacter rectus/showae, Treponema denticola and Bacteroides forsythus in supragingival plaque than subgingival plaque...
  84. ncbi Clinical significance of antibiotic therapy in guided tissue regeneration with a resorbable membrane
    M Minabe
    Oral Reconstruction Therapy Institute, Kagoshima, Japan
    Periodontal Clin Investig 23:20-30. 2001
    ..These findings indicate that antibiotic therapy is not clinically beneficial when combined with GTR therapy with a collagen membrane...
  85. ncbi Intraoral dissemination of treponemes after periodontal therapy
    Benjamin Ehmke
    Department of Periodontology, Westfalian Wilhelm University, Waldeyerstrasse 30, 48149 Munster, Germany
    Clin Oral Investig 8:219-25. 2004
    ..After both therapies, possibly new infection with and/or dissemination of Treponema ssp. occurred, which led to treponemes recovering in different habitats and to increased intraoral prevalence...
  86. ncbi Subgingival microbiota of chilean patients with chronic periodontitis
    Nestor J Lopez
    Department of Conservative Dentistry, Section of Periodontics, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontol 75:717-25. 2004
    ..A study was undertaken to determine the characteristics of the subgingival microbiota of chronic periodontitis in Chileans residing in Santiago...
  87. ncbi Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus and non-diabetes mellitus by polymerase chain reaction
    K Yuan
    Department of Dentistry, National Cheng Kung University Hospital, Tainan, Taiwan
    J Periodontal Res 36:18-24. 2001
    ..periodontal pathogens: Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Eikenella corrodens, Treponema denticola, and Candida albicans by polymerase chain reaction (PCR) between NIDDM and non-DM adults were compared...
  88. ncbi Humoral immune response in early-onset periodontitis: influence of smoking
    J Mooney
    Periodontology and Oral Immunology, University of Glasgow Dental Hospital and School, Scotland, UK
    J Periodontal Res 36:227-32. 2001
    ..periodontal pathogens (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Treponema denticola and Bacteroides forsythus)...
  89. ncbi Detection of putative oral pathogens in acute periradicular abscesses by 16S rDNA-directed polymerase chain reaction
    J F Siqueira
    Department of Dentistry, , Rio de Janeiro, Brazil
    J Endod 27:164-7. 2001
    ..polymerase chain reaction method was used to assess the occurrence of four black-pigmented anaerobic rods, Treponema denticola, and Actinobacillus actinomycetemcomitans in acute periradicular abscesses...
  90. ncbi [Establishment of detection and quantification system of periodontopathic bacteria by molecular biology-technique and molecular analysis of human oral microbiota]
    Mitsuo Sakamoto
    RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198
    Nippon Saikingaku Zasshi 59:387-93. 2004
  91. ncbi Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole
    M Feres
    Department of Periodontology, The Forsyth Institute, Boston MA, USA
    J Clin Periodontol 28:597-609. 2001
    ..94+/-0.23 mm (p<0.01). Levels and proportions of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola were markedly reduced during antibiotic administration and were lower than baseline levels at 360 days...
  92. ncbi "Red complex" (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola) in endodontic infections: a molecular approach
    I N Rôças
    Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:468-71. 2001
    The "red complex," composed of Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola, is implicated in severe forms of periodontal diseases...
  93. ncbi Critical soft tissue parameters of the zygomatic implant
    B Al-Nawas
    Oral and Maxillofacial Surgery, University Mainz, Augustusplatz 2, Mainz, Germany
    J Clin Periodontol 31:497-500. 2004
    ..The soft tissue aspects of the palatal emergence situation have not been described yet. The aim of this study was to evaluate the incidence and clinical impact of possible periimplant alterations of zygomatic implants...
  94. ncbi Heterogeneity of host immunological risk factors in patients with aggressive periodontitis
    K Takahashi
    Department of Periodontology and Endodontology, Okayama University Dental School, Okayama, Japan
    J Periodontol 72:425-37. 2001
    ..significantly elevated antibody levels against Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum compared with the HS group (P < 0.05)...
  95. ncbi Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor
    Muneo Tanaka
    Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
    Microbes Infect 6:1078-83. 2004
    ..including Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Prevotella nigrescens and Treponema denticola, was examined...
  96. ncbi The microbiota of young children from tooth and tongue samples
    A C R Tanner
    The Forsyth Institute, Boston, MA 02115, USA
    J Dent Res 81:53-7. 2002
    ....
  97. ncbi Periodontopathic bacterial infection in childhood
    Shigenobu Kimura
    Department of Oral Microbiology, Iwate Medical University School of Dentistry, Morioka, Japan
    J Periodontol 73:20-6. 2002
    ..We assessed the prevalence by age of 10 putative periodontopathic microorganisms in periodontally healthy children using a polymerase chain reaction (PCR) assay...
  98. ncbi Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria
    Y Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan
    J Dent Res 84:456-61. 2005
    ..Here, we examined the effects of Treponema medium glycoconjugate on the activation of human gingival fibroblasts using phenol-water extracts from ..
  99. ncbi Clinical and microbiological associations in chronic periodontitis
    Allyson Nogueira Moreira
    Department of Periodontology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina
    Acta Odontol Latinoam 17:15-21. 2004
    ..Dark field microscopy was used to analyze the relative proportions of Treponema to the total microbial morphotypes...
  100. ncbi Microbiological findings and host response in patients with peri-implantitis
    Margareta Hultin
    Karolinska Institutet, Institute of Odontology, Department of Periodontology, Huddinge, Sweden
    Clin Oral Implants Res 13:349-58. 2002
    ..Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus and Treponema denticola...
  101. ncbi Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes
    M Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Oral Microbiol Immunol 19:168-76. 2004
    ..six periodontal bacteria: Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans, Treponema denticola, Prevotella intermedia, and Prevotella nigrescens...

Research Grants75

  1. Crane - CheA and its Complexes
    BRIAN CRANE; Fiscal Year: 2009
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish ..
  2. Crane - CheA and its Complexes
    Brian R Crane; Fiscal Year: 2010
    ..Furthermore, many human pathogens such Vibrio cholerae, Helicobacter pylori, Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) rely on chemotaxis and motility to establish ..
  3. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
    ..gingivalis), Treponema denticola and the main focus of this application, Tanerella forsythia (formerly Bacteroides forsythus)...
  4. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..Three bacterial species (Porphyromonas gingivalis, Treponema denticola, Bacteroides forsythus) have been shown to be closely associated with chronic periodontitis in humans, ..
  5. CULTIVABLE AND UNCULTIVABLE PERIODONTAL SPIROCHETES
    Floyd Dewhirst; Fiscal Year: 1993
    ..Currently, there are four known oral spirochete species: Treponema denticola, T. pectinovorum, T. socranskii, and T. vincentii...
  6. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2001
    ..provided after submission indicates that two subtractive hybridization clones a) have homology to the Treponema denticola major outer surface protein (Msp); b) hybridize with multiple restriction fragments in T...
  7. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    GEORGE ORDAL; Fiscal Year: 2009
    ..Campylobacter jejuni, Helicobacter sp., and Treponema pallidum have homologues to CheC, CheD, and CheV, genes first identified and then characterized in B. subtilis. ..
  8. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..The application of genetic advancements and the availability of genomic sequences for Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp. are providing a wealth of new information...
  9. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..The application of genetic advancements and the availability of genomic sequences of Borrelia burgdorferi, Treponema pallidum, T. denticola, and new sequencing projects in Leptospira spp, are proving a wealth of new information...
  10. Extracellular matrix adhesins of Treponema pallidum
    CAROLINE CAMERON; Fiscal Year: 2009
    Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  11. Extracellular matrix adhesins of Treponema pallidum
    Caroline E Cameron; Fiscal Year: 2010
    Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  12. Extracellular matrix adhesins of Treponema pallidum
    CAROLINE CAMERON; Fiscal Year: 2007
    Syphilis, caused by the spirochete bacterium Treponema pallidum subsp. pallidum, is a chronic bacterial infection that remains a public health concern worldwide...
  13. BACTERIAL PROTEINASES IN PERIODONTAL DISEASE
    JAN S POTEMPA; Fiscal Year: 2010
    ..Gram-negative, anaerobic bacterial species, among which, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola constitute the so called "red complex" of microorganisms frequently associated with the development ..
  14. BACTERIAL PROTEINASES IN PERIODONTAL DISEASE
    Jan Potempa; Fiscal Year: 2009
    ..Gram-negative, anaerobic bacterial species, among which, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola constitute the so called "red complex" of microorganisms frequently associated with the development ..
  15. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Many spirochetes, including Treponema pallidum and the several Borrelia species that cause Lyme disease and relapsing fever cross the BBB...
  16. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2000
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Treponema denticola and Prevotella intermedia...
  17. Antigenic Variation of TprK in Treponema pallidum
    Sheila A Lukehart; Fiscal Year: 2010
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  18. Antigenic Variation of TprK in Treponema pallidum
    Sheila Lukehart; Fiscal Year: 2009
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  19. Antigenic Variation of TprK in Treponema pallidum
    Sheila A Lukehart; Fiscal Year: 2010
    ..sequence variation in seven discrete regions (termed V regions) of TprK, a putative surface- exposed protein of Treponema pallidum, we hypothesized that this represents an antigenic variation system, leading to immune evasion and ..
  20. BACTERIA AND LYMPHOCYTE SUPPRESSION IN PERIODONTITIS
    BRUCE SHENKER; Fiscal Year: 2005
    ..human T- and B-cell function; these include Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Treponema denticola...
  21. Treponema pallidum: Pathogenesis-associated molecules
    Sheila A Lukehart; Fiscal Year: 2010
    Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  22. Treponema pallidum: Pathogenesis-associated molecules
    Sheila Lukehart; Fiscal Year: 2009
    Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  23. Treponema pallidum:Pathogenesis-associated molecules
    Sheila Lukehart; Fiscal Year: 2007
    Subspecies of the pathogenic spirochete, Treponema pallidum, are the agents of syphilis, yaws, and bejel. T. carateum causes the human infection, pinta...
  24. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of periodontitis and thus a ..
  25. IMMUNE MECHANISMS IN EXPERIMENTAL SYPHILIS
    Michael Lovett; Fiscal Year: 1999
    ..in experimental syphilis has been limited by the fact that the rare outer membrane spanning proteins (TROMP) of Treponema pallidum had not been defined. This proposal is based on isolation of the T...