legionella

Summary

Summary: Gram-negative aerobic rods, isolated from surface water, mud, or thermally polluted lakes or streams. It is pathogenic for man and it has no known soil or animal sources.

Top Publications

  1. ncbi Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
  2. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
  3. ncbi Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions
    Tomoko Kubori
    The 21st Century COE Program, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Microbiol 67:1307-19. 2008
  4. ncbi Legionella metaeffector exploits host proteasome to temporally regulate cognate effector
    Tomoko Kubori
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 6:e1001216. 2010
  5. ncbi Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536-0812, USA
    Nat Cell Biol 4:945-54. 2002
  6. ncbi The molecular ecology of legionellae
    B S Fields
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 4:286-90. 1996
  7. ncbi Purification and characterization of a UDP-glucosyltransferase produced by Legionella pneumophila
    Iouri Belyi
    Gamaleya Research Institute of Epidemiology and Microbiology, Moscow 123098, Russia
    Infect Immun 71:181-6. 2003
  8. ncbi The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water
    H Y Lau
    National Exposure Research Laboratory, U S Environmental Protection Agency, Cincinnati, OH 45268, USA
    J Appl Microbiol 107:368-78. 2009
  9. ncbi Isolation of Legionella-containing vacuoles by immuno-magnetic separation
    Simon Urwyler
    Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
    Curr Protoc Cell Biol . 2010
  10. ncbi Temperature-regulated formation of mycelial mat-like biofilms by Legionella pneumophila
    Zhenyu Piao
    Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    Appl Environ Microbiol 72:1613-22. 2006

Research Grants

  1. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas Cianciotto; Fiscal Year: 2009
  2. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas P Cianciotto; Fiscal Year: 2010
  3. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward Shaw; Fiscal Year: 2007
  4. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
  5. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
  6. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2010
  7. The function of RickA and host factors in Rickettsia actin based motility
    ALISA SERIO; Fiscal Year: 2007
  8. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2007
  9. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
  10. Legionella pneumophila developmental cycle & virulence
    Paul Hoffman; Fiscal Year: 2007

Detail Information

Publications239 found, 100 shown here

  1. ncbi Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
    Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 (Birc1e)...
  2. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. The dot/icm genes encode a protein secretion apparatus that L...
  3. ncbi Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions
    Tomoko Kubori
    The 21st Century COE Program, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Microbiol 67:1307-19. 2008
    b>Legionella pneumophila has a Dot/Icm type IV secretion system used to translocate a number of 'effector proteins' which subvert host cell functions...
  4. ncbi Legionella metaeffector exploits host proteasome to temporally regulate cognate effector
    Tomoko Kubori
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 6:e1001216. 2010
    ..b>Legionella LubX protein functions as an E3 ubiquitin ligase that hijacks the host proteasome to specifically target the ..
  5. ncbi Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536-0812, USA
    Nat Cell Biol 4:945-54. 2002
    It is unknown how Legionella pneumophila cells escape the degradative lysosomal pathway after phagocytosis by macrophages and replicate in an organelle derived from the endoplasmic reticulum. Here we show that, after internalization, L...
  6. ncbi The molecular ecology of legionellae
    B S Fields
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 4:286-90. 1996
    b>Legionella pneumophila is the most highly characterized member of a genus of bacteria that survive as intracellular parasites of freshwater protozoa...
  7. ncbi Purification and characterization of a UDP-glucosyltransferase produced by Legionella pneumophila
    Iouri Belyi
    Gamaleya Research Institute of Epidemiology and Microbiology, Moscow 123098, Russia
    Infect Immun 71:181-6. 2003
    b>Legionella pneumophila is the agent of Legionnaires' disease. It invades and replicates within eukaryotic cells, including aquatic protozoans, mammalian macrophages, and epithelial cells...
  8. ncbi The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water
    H Y Lau
    National Exposure Research Laboratory, U S Environmental Protection Agency, Cincinnati, OH 45268, USA
    J Appl Microbiol 107:368-78. 2009
    Current models to study Legionella pathogenesis include the use of primary macrophages and monocyte cell lines, various free-living protozoan species and murine models of pneumonia. However, there are very few studies of Legionella spp...
  9. ncbi Isolation of Legionella-containing vacuoles by immuno-magnetic separation
    Simon Urwyler
    Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
    Curr Protoc Cell Biol . 2010
    The environmental bacterium Legionella pneumophila naturally parasitizes free-living amoebae. L...
  10. ncbi Temperature-regulated formation of mycelial mat-like biofilms by Legionella pneumophila
    Zhenyu Piao
    Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    Appl Environ Microbiol 72:1613-22. 2006
    Fifty strains representing 38 species of the genus Legionella were examined for biofilm formation on glass, polystyrene, and polypropylene surfaces in static cultures at 25 degrees C, 37 degrees C, and 42 degrees C...
  11. ncbi Evidence for the presence of Legionella bacteriophages in environmental water samples
    Elke Lammertyn
    Laboratory for Bacteriology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, Belgium
    Microb Ecol 56:191-7. 2008
    The existence and preliminary characterization of bacteriophages active against the Gram-negative human pathogen Legionella pneumophila, the causative agent of a very severe form of pneumonia, are reported...
  12. ncbi Infection due to Legionella species other than L. pneumophila
    Robert R Muder
    Infectious Diseases Section, VA Pittsburgh Healthcare System and University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
    Clin Infect Dis 35:990-8. 2002
    In addition to Legionella pneumophila, 19 Legionella species have been documented as human pathogens on the basis of their isolation from clinical material. Like L...
  13. ncbi Legionella drancourtii sp. nov., a strictly intracellular amoebal pathogen
    Bernard La Scola
    , CNRS UPRESA 6020, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Syst Evol Microbiol 54:699-703. 2004
    A Legionella-like amoebal pathogen (LLAP), formerly named LLAP12(T), was characterized on the basis of microscopic appearance, staining characteristics, growth in Acanthamoeba polyphaga at different temperatures, DNA G+C content, ..
  14. ncbi A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria
    Elena Degtyar
    Department of Molecular Microbiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cell Microbiol 11:1219-35. 2009
    b>Legionella pneumophila infects alveolar macrophages and protozoa through establishment of an intracellular replication niche...
  15. ncbi Development and evaluation of Chlamylege, a new commercial test allowing simultaneous detection and identification of Legionella, Chlamydophila pneumoniae, and Mycoplasma pneumoniae in clinical respiratory specimens by multiplex PCR
    C Ginevra
    , GIMAP, , Saint-Etienne, France
    J Clin Microbiol 43:3247-54. 2005
    ..the simultaneous detection in respiratory samples of Chlamydophila pneumoniae, Mycoplasma pneumoniae, and most Legionella species, as well as PCR inhibitors, by using a multiplex PCR and microplate hybridization...
  16. ncbi Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    Natalie N Whitfield
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:423-32. 2010
    b>Legionella pneumophila, a motile opportunistic pathogen of humans, is restricted from replicating in the lungs of C57BL/6 mice. Resistance of mouse macrophages to L. pneumophila depends on recognition of cytosolic flagellin...
  17. ncbi Comparative assessment of virulence traits in Legionella spp
    O A Terry Alli
    Department of Microbiology and Immunology, College of Medicine, University of Kentucky, Chandler Medical Center, Lexington, KY 40503, USA
    Microbiology 149:631-41. 2003
    b>Legionella pneumophila is a facultative intracellular pathogen that accounts for the majority of cases of Legionnaires' disease in the USA and Europe, but other Legionella spp. have been shown to cause disease...
  18. ncbi Legionella, protozoa, and biofilms: interactions within complex microbial systems
    Michael Taylor
    Department of Environmental Health, Flinders University of South Australia, P O Box 2100, Adelaide, South Australia 5001, Australia
    Microb Ecol 58:538-47. 2009
    Currently, the investigation of Legionella ecology falls into two distinct areas of research activity: (1) that Legionella multiply within water sources by parasitizing amoebic or ciliate hosts or (2) that Legionella grows extracellularly ..
  19. ncbi Legionella and Legionnaires' disease: 25 years of investigation
    Barry S Fields
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 15:506-26. 2002
    ..There is optimism that newly developed guidelines and water treatment practices can greatly reduce the incidence of this preventable illness...
  20. ncbi Recurrent soft tissue abscesses caused by Legionella cincinnatiensis
    J G Gubler
    Department of Medicine, Stadtspital Triemli, CH 8063 Zurich, Switzerland
    J Clin Microbiol 39:4568-70. 2001
    ..Broad-spectrum PCR revealed Legionella cincinnatiensis, which was confirmed by isolation of the organism on special Legionella medium...
  21. ncbi Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testing
    Janet E Stout
    VA Pittsburgh Healthcare System, VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
    Int J Antimicrob Agents 25:302-7. 2005
    ..and telithromycin) and macrolides (clarithromycin, azithromycin and erythromycin) were evaluated against Legionella pneumophila by broth dilution and an HL-60 intracellular model...
  22. ncbi Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp
    J Dubois
    Novabyss Inc, Centre universitaire de sante de l Estrie, 614 rue Bowen Sud, Sherbrooke, Québec J1G 2E9, Canada
    J Antimicrob Chemother 45:41-6. 2000
    ..ofloxacin, ciprofloxacin, azithromycin, clarithromycin, erythromycin and rifampicin were evaluated against Legionella pneumophila serogroups 1-9 and 12 (n = 204) and other Legionella spp. (n = 34)...
  23. ncbi Commercial potting soils as an alternative infection source of Legionella pneumophila and other Legionella species in Switzerland
    S Casati
    Swiss National Reference Centre for Legionella, Cantonal Institute of Microbiology, Bellinzona, Switzerland
    Clin Microbiol Infect 15:571-5. 2009
    b>Legionella spp. are pathogens that can cause Legionnaires' disease in humans through inhalation of contaminated aerosols. The principal reservoir for these microorganisms is water, but Legionella spp...
  24. ncbi Evaluation of the Binax and Biotest urinary antigen kits for detection of Legionnaires' disease due to multiple serogroups and species of Legionella
    R F Benson
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2763-5. 2000
    ..and the Biotest urinary antigen kits for the detection of Legionnaires' disease caused by organisms other than Legionella pneumophila were compared by testing 45 urine samples from non-Legionella pneumophila serogroup 1 patients ..
  25. ncbi Pneumonia due to Legionella feeleii: case report and review of the literature
    J Lee
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Transpl Infect Dis 11:337-40. 2009
    b>Legionella feeleii is a rare cause of community-acquired pneumonia that occurs in immunocompromised hosts who are often receiving corticosteroid therapy...
  26. ncbi Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia
    Heike von Baum
    Institute for Medical Microbiology and Hygiene, University Hospital of Ulm, Germany
    Clin Infect Dis 46:1356-64. 2008
    ..The Competence Network for Community Acquired Pneumonia (CAPNETZ) offers a unique opportunity to study the epidemiology of legionellosis throughout Germany, applying sophisticated diagnostic tools...
  27. ncbi Literature review--efficacy of various disinfectants against Legionella in water systems
    B R Kim
    Ford Research Laboratory, Dearborn, MI 48121, USA
    Water Res 36:4433-44. 2002
    ..and implementing such a measure at its facilities worldwide to provide technical guidance for controlling Legionella in water systems...
  28. ncbi Phylogenetic study of legionella species in pristine and polluted aquatic samples from a tropical Atlantic forest ecosystem
    Fábio R S Carvalho
    Laboratory of Environmental Microbiology, Department of Microbiology, Institute of Biomedical Science, University of Sao Paulo, Room 148 Lineu Prestes avenue, 1374, Cidade Universitária São Paulo, SP, Brazil
    Curr Microbiol 55:288-93. 2007
    b>Legionella species are ubiquitous bacteria in aquatic environments...
  29. ncbi Australian isolates of Legionella longbeachae are not a clonal population
    J C Montanaro-Punzengruber
    Department of Medicine, University of Sydney, New South Wales 2006, Australia
    J Clin Microbiol 37:3249-54. 1999
    b>Legionella longbeachae is almost as frequent a cause of legionellosis in Australia as Legionella pneumophila, but epidemiological investigation of possible environmental sources and clinical cases has been limited by the lack of a ..
  30. ncbi Legionella bozemanae synthesizes phosphatidylcholine from exogenous choline
    Marta Palusinska-Szysz
    Department of Genetics and Microbiology, Institute of Microbiology and Biotechnology, Maria Curie Sklodowska University, Akademicka St 19, PL 20 033 Lublin, Poland
    Microbiol Res 166:87-98. 2011
    The phospholipid class and fatty acid composition of Legionella bozemanae were determined using thin-layer chromatography, gas-liquid chromatography, and matrix-assisted laser desorption ionization-time of flight mass spectrometry...
  31. ncbi Effects of chemically and electrochemically dosed chlorine on Escherichia coli and Legionella beliardensis assessed by flow cytometry
    Yingying Wang
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Appl Microbiol Biotechnol 87:331-41. 2010
    ..and electrochemically dosed chlorine on two models for typical water-borne bacteria (Escherichia coli and Legionella beliardensis) by plating and flow cytometry (FCM) in combination with different fluorescence dyes...
  32. ncbi Development of conventional and real-time NASBA for the detection of Legionella species in respiratory specimens
    K Loens
    Department of Microbiology, University of Antwerp UA, Antwerp, Belgium
    J Microbiol Methods 67:408-15. 2006
    Isothermal nucleic acid sequence-based amplification (NASBA) was applied to detect Legionella 16S rRNA...
  33. ncbi Water quality parameters associated with prevalence of Legionella in hot spring facility water bodies
    Shih Wei Huang
    Department of Earth and Environmental Sciences, National Chung Cheng University, 168 University Road, Minhsiung Township, Chiayi County 62102, Taiwan, ROC
    Water Res 44:4805-11. 2010
    Some species of Legionella are recognized as opportunistic potential human pathogens, such as Legionella pneumophila, which causes legionnaires disease...
  34. ncbi Legionella spp. and legionellosis in southeastern Italy: disease epidemiology and environmental surveillance in community and health care facilities
    Christian Napoli
    Department of Biomedical Science and Human Oncology Hygiene section, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    BMC Public Health 10:660. 2010
    ..The aim of the study is to identify the risk factors for the disease, so allowing better programming of the necessary prevention measures...
  35. ncbi Prevalence of legionella waterline contamination and Legionella pneumophila antibodies in general dental practitioners in London and rural Northern Ireland
    C L Pankhurst
    Division of Oral Medicine, Guy s, King s St Thomas Dental Institute, Guy s Campus, London SE 9RT
    Br Dent J 195:591-4; discussion 581. 2003
    ....
  36. ncbi Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells
    P S Hoffman
    Department of Microbiology and Immunology, University of Tennessee, Memphis 38163
    Infect Immun 58:3380-7. 1990
    A 60-kilodalton (kDa) immunodominant antigen of Legionella pneumophila is a heat shock protein (HSP) of the GroEL class of HSPs. The gene (htpB) coding the 60-kDa protein was localized to a 3.2-kilobase DNA fragment of L...
  37. ncbi Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen
    J S Sampson
    Division of Bacterial Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    Infect Immun 58:3154-7. 1990
    Gene htpB, which encodes the 58-kilodalton protein of Legionella pneumophila, was cloned in Escherichia coli and its complete nucleotide sequence was determined...
  38. ncbi Rapid identification of Legionella spp. by MALDI-TOF MS based protein mass fingerprinting
    Valeria Gaia
    Cantonal Institute of Microbiology, Bellinzona, Switzerland
    Syst Appl Microbiol 34:40-4. 2011
    A set of reference strains representing 38 different Legionella species were submitted to Whole Cell Mass Spectrometry (WCMS) with MALDI-TOF...
  39. ncbi Application of RNA polymerase beta-subunit gene (rpoB) sequences for the molecular differentiation of Legionella species
    Kwan Soo Ko
    Department of Microbiology and Cancer Research Institute, Institute of Endemic Diseases, SNUMRC, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Seoul 110-799
    J Clin Microbiol 40:2653-8. 2002
    The nucleotide sequences of the partial rpoB gene were determined from 38 Legionella species, including 15 serogroups of Legionella pneumophila...
  40. ncbi Influence of Acanthamoeba castellanii on intracellular growth of different Legionella species in human monocytes
    B Neumeister
    Abteilung Transfusionsmedizin, Universitatsklinikum Tubingen, 72076 Tubingen, Germany
    Appl Environ Microbiol 66:914-9. 2000
    Previous studies using a murine model of coinhalation of Legionella pneumophila and Hartmannella vermiformis have shown a significantly enhanced intrapulmonary growth of L. pneumophila in comparison to inhalation of legionellae alone (J...
  41. ncbi Chemical structure and biological significance of lipopolysaccharide from Legionella
    Marta Palusinska-Szysz
    Department of Genetics and Microbiology, Maria Curie Skłodowska University, Lublin, Poland
    Recent Pat Antiinfect Drug Discov 4:96-107. 2009
    b>Legionella are aerobic, gram-negative, motile, rod-shaped bacteria, which form a distinct taxonomic unit within the gamma - 2 subdivision of the Proteobacteria...
  42. ncbi Legionella confirmation using real-time PCR and SYTO9 is an alternative to current methodology
    Steven Giglio
    Australian Water Quality Centre, PMB 3, Salisbury, South Australia 5108, Australia
    Appl Environ Microbiol 71:8944-8. 2005
    The currently accepted culture techniques for the detection of Legionella spp. in water samples (AS/NZS 3896:1998 and ISO 11731 standard methods) are slow and laborious, requiring from 7 to 14 days for a result...
  43. ncbi First isolation of Legionella species, including L. pneumophila serogroup 1, in Greek potting soils: possible importance for public health
    E N Velonakis
    Department of Microbiology, National School of Public Health and Central Public Health Laboratory, Athens Hellenic Centre for Infectious Disease Control KEELPNO, Ministry of Health, Athens, Greece
    Clin Microbiol Infect 16:763-6. 2010
    A total of 21 Legionella isolates were recovered from six out of 22 samples of potting soil from the Athens area, Greece. Legionella pneumophila (serogroups 1 and 2-15) and species and serotypes included in the group of L...
  44. ncbi Comparison of three Legionella urinary antigen assays during an outbreak of legionellosis in Belgium
    Kristien Dirven
    Laboratory of Medical Microbiology, University of Antwerp UA, Wilrijk, Belgium
    J Med Microbiol 54:1213-6. 2005
    During an outbreak of legionellosis in Belgium, urine samples of 32 legionellosis patients were tested with three Legionella urinary antigen assays: the Biotest enzyme immunoassay (EIA) kit, the Binax EIA kit and the Binax NOW ..
  45. ncbi Free-living amoebae, Legionella and Mycobacterium in tap water supplied by a municipal drinking water utility in the USA
    Francine Marciano-Cabral
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Water Health 8:71-82. 2010
    b>Legionella and Mycobacterium can proliferate within free-living amoebae (FLA) where they are protected from disinfectants at concentrations that can kill bacteria but not protozoa...
  46. ncbi Extrapulmonary Legionella micdadei infection in a previously healthy child
    Xuan Qin
    Department of Laboratories and Pathology, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Infect Dis J 21:1174-6. 2002
    ..Surgical drainage specimens from the mass were bacterial culture-negative. Legionella micdadei infection was diagnosed by a two step PCR-nucleic acid sequencing method and supported by organism-..
  47. ncbi Legionella spp. and Legionnaires' disease
    B M W Diederen
    Regional Laboratory of Public Health Haarlem, Boerhaavelaan 26, 2035 RC Haarlem, The Netherlands
    J Infect 56:1-12. 2008
    Infection with Legionella spp. is an important cause of community- and hospital-acquired pneumonia, occurring both sporadically and in outbreaks. Infection with Legionella spp...
  48. ncbi Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium
    Olga Shevchuk
    Institut fur Mikrobiologie, Technische Universitat Braunschweig, Braunschweig, Germany
    Int J Med Microbiol 299:489-508. 2009
    b>Legionella pneumophila, the agent of Legionnaires' disease, replicates intracellularly within specialized phagosomes of human macrophages and amoebae...
  49. ncbi A specific genomic location within the icm/dot pathogenesis region of different Legionella species encodes functionally similar but nonhomologous virulence proteins
    Michal Feldman
    Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel
    Infect Immun 72:4503-11. 2004
    b>Legionella pneumophila, the major causative agent of Legionnaires' disease, is a facultative intracellular pathogen that grows within human macrophages and amoebae...
  50. ncbi The transfer region of IncI1 plasmid R64: similarities between R64 tra and legionella icm/dot genes
    T Komano
    Department of Biology, Tokyo Metropolitan University, Minamiohsawa, Hachioji shi, Tokyo 192 0397, Japan
    Mol Microbiol 35:1348-59. 2000
    ..The amino acid sequences of 10 R64 tra/trb products share similarity with those of the icm/dot products of Legionella pneumophila that are responsible for its virulence, suggesting that the R64 transfer and L...
  51. ncbi Epidemiologic investigation of a restaurant-associated outbreak of Pontiac fever
    Timothy F Jones
    Tennessee Department of Health, Nashville, TN 37247, USA
    Clin Infect Dis 37:1292-7. 2003
    ..5; P=.005). Legionella anisa was cultured from water samples obtained from the fountain pool...
  52. ncbi A mutation in an ompR-like gene on a Legionella longbeachae serogroup 1 plasmid attenuates virulence
    Robyn M Doyle
    Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int J Med Microbiol 292:227-39. 2002
    Examination of a panel of Legionella longbeachae serogroup 1 strains using a guinea pig model of virulence determined that this clonal species of Legionella shows a remarkable variation in symptoms and disease outcome (Doyle et al...
  53. ncbi Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila in elderly patients with stroke (C-PEPS, M-PEPS, L-PEPS): a case-control study on the infectious burden of atypical respiratory pathogens in elderly patients with acute cerebrovascula
    Joseph Ngeh
    Department of Geriatric and Stroke Medicine, Warwick Hospital, Lakin Rd, Warwick CV34 5BW, UK
    Stroke 36:259-65. 2005
    ..We investigated whether the risk of cerebrovascular disease is associated with Legionella pneumophila infection and the aggregate number/infectious burden of these atypical respiratory pathogens.
  54. ncbi Activity of BMS284756 (T-3811) tested against anaerobic bacteria, Campylobacter jejuni, Helicobacter pylori and Legionella spp
    P R Rhomberg
    University of Iowa College of Medicine, Iowa City, IA, USA
    Diagn Microbiol Infect Dis 40:45-9. 2001
    ..and trovafloxacin were evaluated against Campylobacter jejuni (38 strains), Helicobacter pylori (21 strains), Legionella spp. (66 strains), and 197 anaerobic isolates. BMS284756 (MIC(90), 0...
  55. ncbi Isolation of pathogenic Legionella species and legionella-laden amoebae in dental unit waterlines
    T Singh
    Department of Immunology and Microbiology, National Institute for Occupational Health, P O Box 4788, Johannesburg 2000, South Africa
    J Hosp Infect 61:257-62. 2005
    b>Legionella released into the air during treatment are a potential source of infection. Water stagnation in dental unit waterlines (DUWLs) creates biofilms and promotes the proliferation of these micro-organisms...
  56. ncbi Use of terminal tap water filter systems for prevention of nosocomial legionellosis
    R P Vonberg
    Division of Hospital Epidemiology and Infection Control, Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Hosp Infect 60:159-62. 2005
    Hospital water supplies often contain Legionella spp. and represent a potential source of nosocomial infection, especially for immunocompromised patients or those in intensive care units...
  57. ncbi Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species
    Christel Cazalet
    Unité de Génomique des Microorganismes Pathogènes, Institut Pasteur, 75724 Paris Cedex 15, France
    Genome Res 18:431-41. 2008
    Genomics can provide the basis for understanding the evolution of emerging, lethal human pathogens such as Legionella pneumophila, the causative agent of Legionnaires' disease...
  58. ncbi Coevolution between nonhomologous but functionally similar proteins and their conserved partners in the Legionella pathogenesis system
    Michal Feldman
    Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 102:12206-11. 2005
    b>Legionella pneumophila, the causative agent of Legionnaires' disease, and other pathogenic Legionella species multiply inside protozoa and human macrophages by using the intracellular multiplication (Icm)/defect in organelle trafficking (..
  59. ncbi Development of conventional and real-time PCR assays for detection of Legionella DNA in respiratory specimens
    K Rantakokko-Jalava
    Department of Medical Microbiology, University of Turku, Turku, Finland
    J Clin Microbiol 39:2904-10. 2001
    ..and validation of a PCR assay based on the use of new 16S ribosomal DNA (rDNA)-targeted primers to detect Legionella DNA in respiratory specimens are described...
  60. ncbi Growth-supporting activity for Legionella pneumophila in tap water cultures and implication of hartmannellid amoebae as growth factors
    R M Wadowsky
    Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261
    Appl Environ Microbiol 54:2677-82. 1988
    ..cyanobacteria, heterotrophic bacteria, free-living amoebae, and ciliated protozoa may support growth of Legionella pneumophila. Studies were done with two tap water cultures (WS1 and WS2) containing L...
  61. ncbi Entry and intracellular growth of Legionella dumoffii in alveolar epithelial cells
    K Maruta
    Departments of Microbiology and Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Respir Crit Care Med 157:1967-74. 1998
    We have found that Legionella dumoffii strain Tex-KL (ATCC 33343) invades into and proliferates in the human lung alveolar epithelial-cell line A549 in vitro...
  62. ncbi Prevalence of anti-legionella antibodies among Italian hospital workers
    P Borella
    Department of Public Health Sciences, University of Modena and Reggio Emilia, Italy
    J Hosp Infect 69:148-55. 2008
    This study evaluated the prevalence of anti-legionella antibodies in workers at hospitals with a long-term history of legionella contamination...
  63. ncbi Pontiac fever: an operational definition for epidemiological studies
    Paul Tossa
    Département Environnement et Santé Publique, INSERM ERI 11, Henri Poincare University, BP 184 54 505 Vandoeuvre lès Nancy, France
    BMC Public Health 6:112. 2006
    ..Detection of Pontiac fever is a marker of an environmental contamination by Legionella and should thereby call for prevention measures in order to prevent outbreak of Legionnaire's disease...
  64. ncbi Legionella anisa and hospital water systems
    Victor L Yu
    J Infect Chemother 10:133; author reply 134. 2004
  65. ncbi Reusable terminal tap water filters for nosocomial legionellosis prevention
    Ralf Peter Vonberg
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Ann Hematol 84:403-5. 2005
    Hospital water supplies often contain Legionella spp. and therefore represent a source of nosocomial infection especially for immunocompromised patients in intensive care or organ transplant units...
  66. ncbi Legionella infection risk from domestic hot water
    Paola Borella
    Dipartamento di Scienze Igienistiche, Microbiologiche e Biostatistiche, University of Modena and Reggio E, Via Campi 287, I 41100 Modena, Italy
    Emerg Infect Dis 10:457-64. 2004
    We investigated Legionella and Pseudomonas contamination of hot water in a cross-sectional multicentric survey in Italy. Chemical parameters (hardness, free chlorine, and trace elements) were determined. Legionella spp...
  67. ncbi Colonization of a water system by Legionella organisms and nosocomial legionellosis: a 5-year report from a large Italian hospital
    S Ditommaso
    Infect Control Hosp Epidemiol 27:532-5. 2006
  68. ncbi Influence of amoebae and physical and chemical characteristics of water on presence and proliferation of Legionella species in hospital water systems
    Agnes Lasheras
    Service Hygiène Hospitalière, Hopital Pellegrin, CHU Bordeaux, Bordeaux Cedex, France
    Am J Infect Control 34:520-5. 2006
    ..pH, hardness, conductivity, and residual chlorine and the presence of amoebae as growth-promoting factors for Legionella species and (2) to determine eradication measures for water distribution systems to seek ways of reducing the ..
  69. ncbi [Legionella infections in hospitals -- experts stress prevention]
    Pall Bergjohann
    Kinderkrankenschwester 24:342. 2005
  70. ncbi Clinical-environmental surveillance of legionellosis: an experience in Southern Italy
    Maria Teresa Montagna
    Department of Internal Medicine and Public Health Hygiene Section, University of Bari, P zza G Cesare, 1170124, Bari, Italy
    Eur J Epidemiol 21:325-31. 2006
    ..The urinary antigen and anti-Legionella antibody titre were assayed in each subject, and direct searches for the microorganism were made in biological ..
  71. ncbi [Environmental diffusion of Legionella spp and legionellosis frequency among patients with pneumonia: preliminary results of a multicentric Italian survey]
    P Borella
    Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Universita degli Studi di Modena e Reggio Emilia
    Ann Ig 15:493-503. 2003
    ..To improve knowledge on factors associated with Legionella spp colonisation in hot waters, to detect cases and to characterize risk factors in subjects which develop ..
  72. ncbi Legionella pneumonia: many cases of Legionnaire disease go unreported or unrecognized
    Betsy Todd
    New York Presbyterian Hospital, Columbia University Medical Center, in New York City, USA
    Am J Nurs 105:35-6, 38. 2005
  73. ncbi [Legionella and legionellosis: of water, bacteria and men]
    O Gaillot
    Laboratoire de Bacteriologie virologie, Faculté de Médecine de Rennes 1 C H U de Rennes 3
    Ann Pharm Fr 62:244-6. 2004
    b>Legionella species are natural dwellers of stagnant waters. Inhalation of contaminated aerosols may result in pneumonia, with a noteworthy mortality rate (20%)...
  74. ncbi Outbreak of travel-related pontiac fever among hotel guests illustrating the need for better diagnostic tests
    Gregory D Huhn
    Illinois Department of Public Health, Chicago, IL, USA
    J Travel Med 12:173-9. 2005
    ..Patient sera were tested by hemagglutination assay for antibodies to Legionella species. RESULTS: Among 204 questionnaire respondents from 15 states and Canada, 50 met the case definition...
  75. ncbi [Pathogenesis, diagnosis and therapy of Legionella infections]
    P C Lück
    Institut fur Medizinische Mikrobiologie, Nationales Konsiliarlabor für Legionellen, TU Dresden, Fiedlerstrasse 42, 01307 Dresden
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:439-49. 2006
    b>Legionella species are ubiquitous in aquatic environments. About 50 years ago they entered the engineered (technical) environment, i.e. warm water systems with zones of stagnation. Since that time they represent a hygienic problem...
  76. ncbi Surveillance for waterborne-disease outbreaks associated with drinking water--United States, 2001-2002
    Brian G Blackburn
    Division of Parasitic Diseases, National Center for Infectious Diseases, CDC, USA
    MMWR Surveill Summ 53:23-45. 2004
    ..This surveillance system is the primary source of data concerning the scope and effects of waterborne disease outbreaks on persons in the United States...
  77. ncbi One-year surveillance of legionellosis in burned patients and Legionella environmental monitoring
    L Franzin
    Infectious Diseases Unit, University of Turin, Corso Svizzera 164, 10149 Turin, Italy
    Burns 31:50-4. 2005
    Burned patients have a theoretically high risk of Legionella infection because burns produce a compromised immune system. Cutaneous surfaces are without protective barriers, and bathing tank water is frequently used for washing and caring...
  78. ncbi Quantitative real-time Legionella PCR for environmental water samples: data interpretation
    Philippe Joly
    , INSERM E-0230, , IFR 62, 7 rue Guillaume-Paradin, 69372 Lyon Cedex 08, France
    Appl Environ Microbiol 72:2801-8. 2006
    Quantitative Legionella PCRs targeting the 16S rRNA gene (specific for the genus Legionella) and the mip gene (specific for the species Legionella pneumophila) were applied to a total of 223 hot water system samples (131 in one laboratory ..
  79. ncbi Microbiological evaluation of dental unit water systems in general dental practice in Europe
    J T Walker
    Health Protection Agency, Porton Down, Salisbury, UK
    Eur J Oral Sci 112:412-8. 2004
    ..49 (GR) to 3.22 (DK) log CFU.cm(-2). Opportunistic pathogens such as legionellae (DK and ES), including Legionella pneumophila SG1 (DK and GR), and Mycobacterium spp. (DK, NL, GR, D and ES) were recovered occasionally...
  80. ncbi Detection and identification of Legionella species from groundwaters
    Teresa Brooks
    Centre for Research on Environmental Microbiology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health A 67:1845-59. 2004
    ..Of the 114 total samples of water and biofilm tested, 29.1% and 28.2% were positive for Legionella by cultivation and polymerase chain reaction (PCR), respectively...
  81. ncbi Prevalence study of Legionella spp. contamination in ferries and cruise ships
    Antonio Azara
    Hygiene and Preventive Medicine Institute, University of Sassari, Sassari, Italy
    BMC Public Health 6:100. 2006
    ..Aim of our study was: to describe the frequency and severity of Legionella spp...
  82. ncbi Water ecology of Legionella and protozoan: environmental and public health perspectives
    Paola Borella
    Department of Hygiene and Microbiology, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Biotechnol Annu Rev 11:355-80. 2005
    Ecological studies on Legionella spp...
  83. ncbi [Physicochemical factors influencing distribution of Legionella species in Japanese hot springs]
    Takeshi Sasahara
    Department of Microbiology and Parasitology, Kitasato University School of Medicine
    Kansenshogaku Zasshi 78:545-53. 2004
    We examined the relationship between the distribution of Legionella bacteria and various physicochemical characteristics of hot springs in Japan. Legionella bacteria were isolated from 52 (49...
  84. ncbi Evaluation of the effectiveness of the Pastormaster method for disinfection of legionella in a hospital water distribution system
    E F Peiró Callizo
    Department of Health Care, Osakidetza Basque Health Service, Spain
    J Hosp Infect 60:150-8. 2005
    ..distribution systems at a specific point to a sufficient temperature for a minimum amount of time to eradicate legionella. The object of this study was to evaluate the effectiveness of the Pastormaster method for legionella ..
  85. ncbi Microbiological investigations on a nosocomial case of Legionella pneumophila pneumonia associated with water birth and review of neonatal cases
    L Franzin
    Infectious Diseases Unit, University of Turin, Turin, Italy
    Infez Med 12:69-75. 2004
    A case of Legionella pneumophila 1 pneumonia, confirmed by positive serology and urinary antigen, occurred in a 7-day old neonate after water birth in hospital...
  86. ncbi In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila
    Paul H Edelstein
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Antimicrob Agents Chemother 49:2533-5. 2005
    LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC50 for 20 Legionella sp. strains was 4 microg/ml, versus 0.06, 0.25, and <or=0...
  87. ncbi A 3-year follow-up study of anti-Legionella antibodies in users of Japanese 24-hour hot water baths
    Masahiro Irie
    Institute of Health Science, Kyushu University, Japan
    J Occup Health 46:68-77. 2004
    ..Ninety-two subjects (85 males and 7 females), who had had their anti-Legionella pneumophila (Lp) serum antibody titers measured in our initial study in 1997 and consented to blood sampling 3 ..
  88. ncbi Development of an improved PCR-ICT hybrid assay for direct detection of Legionellae and Legionella pneumophila from cooling tower water specimens
    Yu-Tze Horng
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No. 1. Chan-Dar Street 100, Taipei, Taiwan, ROC
    Water Res 40:2221-9. 2006
    ..traditional multiplex-nested PCR and ICT, (a lateral-flow device) was developed for direct detection of Legionella bacteria from environmental cooling tower samples. The partial 16S rDNA (specific for Legionella spp...
  89. ncbi Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey
    Victor L Yu
    Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, Pennsylvania 15240, USA
    J Infect Dis 186:127-8. 2002
    ..b>Legionella pneumophila constituted 91.5% of the isolates. Serogroup 1 was the predominant serogroup (84...
  90. ncbi Legionella in clinical specimens and hospital water supply facilities: molecular detection and genotyping of the isolates
    J A Qasem
    Department of Applied Medical Sciences, College of Health Sciences, The Public Authority for Applied Education and Training, Kuwait University, Kuwait
    Med Princ Pract 17:49-55. 2008
    To evaluate genus- and species-specific polymerase chain reactions (PCRs) for the detection of the genus Legionella and the species Legionella pneumophila in clinical specimens and hospital water supplies, and to establish a simple and ..
  91. ncbi Serological evidence of Legionella species infection in acute exacerbation of COPD
    D Lieberman
    The Pulmonary Unit, Soroka Medical Centre and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva Israel
    Eur Respir J 19:392-7. 2002
    ..exacerbations of chronic obstructive pulmonary disease (AECOPD) with serological evidence of infection with Legionella spp. (Lsp). Two-hundred and forty hospital admissions for AECOPD of 213 patients were included in the study...
  92. ncbi Cross-reactivity and sensitivity of two Legionella urinary antigen kits, Biotest EIA and Binax NOW, to extracted antigens from various serogroups of L. pneumophila and other Legionella species
    Chikako Okada
    Laboratory of Clinical Microbiology, Toranomon Hospital, Tokyo, Japan
    Microbiol Immunol 46:51-4. 2002
    b>Legionella antigen detection kits for diagnosing legionellosis from urine have become widely used, but basic information about reactivity of the kits to non-serogroup (SG) 1 L. pneumophila and other Legionella species remains incomplete...
  93. ncbi [A study on contamination from Legionella spp. at a home for the elderly in Toyohashi City]
    S Yamamoto
    Toyohashi City Health Center
    Nippon Koshu Eisei Zasshi 48:914-22. 2001
    OBJECTIVE: Legionnaires disease has been attributed to Legionella spp. in the water distribution systems of buildings. However, recently cases due to contamination of thermal-bath water have been reported in Japan...
  94. ncbi Gram-negative bacteria in water distribution systems of hospitals
    Nimfa Maria Stojek
    Department of Occupational Biohazards, Institute of Agricultural Medicine, Jaczewskiego 2, 20 090 Lublin, Poland
    Ann Agric Environ Med 15:135-42. 2008
    ..The samples were examined for the presence and species composition of Legionella, Gram-negative bacteria belonging to family Enterobacteriaceae (GNB-E) and Gram-negative bacteria not belonging ..
  95. ncbi Monitoring Legionella species in hospital water systems. Link with disease and evaluation of different detection methods
    Maria Koziol-Montewka
    Department of Medical Microbiology, Medical University of Lublin, Chodzki 1, 20 093 Lublin, Poland
    Ann Agric Environ Med 15:143-7. 2008
    The aim of this work was to evaluate three currently available isolation methods for Legionella using water samples and swabs of a single pediatric hospital water system...
  96. ncbi Design and implementation of a protocol for the detection of Legionella in clinical and environmental samples
    Elizabeth J Nazarian
    Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    Diagn Microbiol Infect Dis 62:125-32. 2008
    Our laboratory has developed a novel real-time polymerase chain reaction (PCR) assay for the detection of Legionella pneumophila and differentiation from other Legionella spp. in clinical and environmental samples...
  97. ncbi Impact of a silver layer on the membrane of tap water filters on the microbiological quality of filtered water
    Ralf Peter Vonberg
    Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Germany
    BMC Infect Dis 8:133. 2008
    ..Terminal tap water filters may be used to prevent nosocomial Legionnaires' disease. We present data from water samples using an improved kind of tap water filters...
  98. ncbi [Epidemiology and laboratory diagnostics of legionellae]
    Z Szénási
    Szegedi Tudomanyegyetem, Szent Györgyi Albert Orvos és Gyógyszerésztudományi Centrum, Általános Orvostudományi Kar, Klinikai Mikrobiológiai Diagnosztikai Intézet
    Orv Hetil 142:1035-43. 2001
    The severe pulmonary disease caused by the inhalation of the different Legionella species is called Legionella pneumonia, while the name of the pulmonary disease caused by the most common Legionella (L...
  99. ncbi Legionella and community-acquired pneumonia: a review of current diagnostic tests from a clinician's viewpoint
    G W Waterer
    Methodist Le Bonheur Healthcare Foundation, Memphis, Tennessee, USA
    Am J Med 110:41-8. 2001
    Many physicians are unaware of the limitations of the available tests for diagnosing infections with Legionella organisms...
  100. ncbi Sensitive genus-specific detection of Legionella by a 16S rRNA based sandwich hybridization assay
    Tarja Leskelä
    Bioprocess Engineering Laboratory, Department of Process and Environmental Engineering and Biocenter Oulu, University of Oulu, PO Box 4300, FI 90014 University of Oulu, Finland
    J Microbiol Methods 62:167-79. 2005
    The aim of this study was to develop a sensitive, cultivation-independent analytical method for Legionella in man-made water systems which can be performed within one day in crude sample extracts...
  101. ncbi The importance of different laboratory methods in Legionella diagnosis in medical care
    W Mathys
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 270:122-30. 1988
    ..In patients with acu a of unknown origin serological tests of Legionella antibodies are no c. Antibody titers of not infected and with Legionella infected patie gnificant difference...

Research Grants85

  1. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas Cianciotto; Fiscal Year: 2009
    b>Legionella pneumophila (Lp) is the primary agent of Legionnaires' disease, a common and potentially fatal form of pneumonia...
  2. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas P Cianciotto; Fiscal Year: 2010
    b>Legionella pneumophila (Lp) is the primary agent of Legionnaires'disease, a common and potentially fatal form of pneumonia...
  3. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward Shaw; Fiscal Year: 2007
    ..Mile Phase I strain) has been sequenced and contains genes homologous to the type IV secretion system (TFSS) of Legionella pneumophila, suggesting that C...
  4. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  5. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  6. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2010
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  7. The function of RickA and host factors in Rickettsia actin based motility
    ALISA SERIO; Fiscal Year: 2007
    ..To determine whether RickA is translocated by the TFSS, RickA will be expressed in Legionella pneumophila and its ability to be translocated by the L...
  8. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2007
    ..The genera we will focus on include agents of lung, cutaneous, and tissue infections (Mycobacterium, Nocardia, Legionella), microaerophilic gastro-intestinal pathogens (Helicobacter, Campylobacter, Arcobacter, Wolinella), and ..
  9. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
    ..Some structural features of/?, leguminosarum lipid A are seen in human pathogens. Legionella pneumophila lipid A i contains a C28 chain, while Porphyromonas gingivalis and Helicobacter pylori lipid A lack ..
  10. Legionella pneumophila developmental cycle & virulence
    Paul Hoffman; Fiscal Year: 2007
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires' disease...
  11. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  12. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2009
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  13. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  14. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2007
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  15. Legionella pneumophila developmental cycle & virulence
    Paul Hoffman; Fiscal Year: 2009
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires' disease...
  16. Role of caspases in Legionella pneumophila pulmonary infection
    Amal Amer; Fiscal Year: 2009
    Role of caspases in Legionella pneumophila pulmonary infection. Legionella pneumophila (L...
  17. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires'disease...
  18. Role of caspases in Legionella pneumophila pulmonary infection
    Amal O Amer; Fiscal Year: 2010
    Role of caspases in Legionella pneumophila pulmonary infection. Legionella pneumophila (L...
  19. Salmonella evasion of NADPH oxidase-dependent killing
    Andres Vazquez Torres; Fiscal Year: 2007
    ..oxidase but will also identify potential molecular targets common to intracellular pathogens such as Salmonella, Mycobacterium, and Legionella that are capable of thwarting the normal maturation of the nascent phagosome.
  20. Gene Expression Patterns and Lifestyles in Legionella
    Howard Shuman; Fiscal Year: 2009
    b>Legionella pneumophila, the gram-negative species that causes legionnaires' disease and other acute respiratory diseases, replicates within a wide range of phagocytic host cells. During legionnaires' disease, L...
  21. Gene Expression Patterns and Lifestyles in Legionella
    Howard Shuman; Fiscal Year: 2007
    b>Legionella pneumophila, the gram-negative species that causes legionnaires' disease and other acute respiratory diseases, replicates within a wide range of phagocytic host cells. During legionnaires' disease, L...
  22. Macrophage transcriptional responses to Legionella pneumophila
    Russell E Vance; Fiscal Year: 2010
    b>Legionella pneumophila is a protypical example of an emerging infectious disease threat...
  23. GENETIC DETERMINANTS OF PATHOGENICITY IN LEGIONELLA
    Lucy Tompkins; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Legionella pneumophila is a facultative intracellular pathogen that grows inside protozoans in fresh water sources...
  24. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2007
    ..tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, Staphylococcus aureus and Bacillus anthracis)...
  25. GENETIC DETERMINANT OF PATHOGENICITY IN LEGIONELLA
    Lucy Tompkins; Fiscal Year: 1993
    DESCRIPTION: (Adapted from applicant's abstract). Legionella pneumophila, the agent of Legionnaire's disease, causes a significant proportion of both community-acquired and nosocomial pneumonia in the U.S. each year...
  26. Macrophage transcriptional responses to Legionella pneumophila
    RUSSELL VANCE; Fiscal Year: 2009
    b>Legionella pneumophila is a protypical example of an emerging infectious disease threat...
  27. Facility Airborne Biological Toxin Alarm System
    John Parrish; Fiscal Year: 2005
    ..system will detect more routine threats to indoor lealth such as molds and fungi (Aspergillus) and bacteria (Legionella)...
  28. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004
    Description (Adapted from applicant's abstract): The ability of Legionella pneumophila (Lpn) to cause pneumonia is dependent on intracellular replication within pulmonary phagocytic and epithelial cells...
  29. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis Lopatin; Fiscal Year: 2009
    ..it has been shown that protective response to stress proteins may be involved in control of diseases like IBD, Legionella, Yersinia, Chlamydia and H. pylori infections and arteriosclerosis...
  30. Type IV Secretion Systems in Legionella pneumophila
    HOWARD STEINMAN; Fiscal Year: 2009
    b>Legionella pneumophila, the causative organism of Legionnaires' disease, is a fresh water bacterium that can invade amoebae and macrophages and replicate in membrane bound phagosomes...
  31. Type IV Secretion Systems in Legionella pneumophila
    HOWARD STEINMAN; Fiscal Year: 2007
    b>Legionella pneumophila, the causative organism of Legionnaires' disease, is a fresh water bacterium that can invade amoebae and macrophages and replicate in membrane bound phagosomes...