legionella

Summary

Summary: Gram-negative aerobic rods, isolated from surface water, mud, or thermally polluted lakes or streams. It is pathogenic for man and it has no known soil or animal sources.

Top Publications

  1. pmc Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
  2. pmc Legionella and Legionnaires' disease: 25 years of investigation
    Barry S Fields
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 15:506-26. 2002
  3. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
  4. doi Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors
    Jianning Ge
    National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China
    Cell Microbiol 13:1870-80. 2011
  5. doi Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions
    Tomoko Kubori
    The 21st Century COE Program, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Microbiol 67:1307-19. 2008
  6. ncbi Legionella spp. and Legionnaires' disease
    B M W Diederen
    Regional Laboratory of Public Health Haarlem, Boerhaavelaan 26, 2035 RC Haarlem, The Netherlands
    J Infect 56:1-12. 2008
  7. pmc Legionella metaeffector exploits host proteasome to temporally regulate cognate effector
    Tomoko Kubori
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 6:e1001216. 2010
  8. ncbi The molecular ecology of legionellae
    B S Fields
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 4:286-90. 1996
  9. ncbi Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Nat Cell Biol 4:945-54. 2002
  10. doi The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water
    H Y Lau
    National Exposure Research Laboratory, U S Environmental Protection Agency, Cincinnati, OH 45268, USA
    J Appl Microbiol 107:368-78. 2009

Research Grants

Detail Information

Publications286 found, 100 shown here

  1. pmc Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
    Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 (Birc1e)...
  2. pmc Legionella and Legionnaires' disease: 25 years of investigation
    Barry S Fields
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 15:506-26. 2002
    ..There is optimism that newly developed guidelines and water treatment practices can greatly reduce the incidence of this preventable illness...
  3. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. The dot/icm genes encode a protein secretion apparatus that L...
  4. doi Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors
    Jianning Ge
    National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China
    Cell Microbiol 13:1870-80. 2011
    b>Legionella pneumophila, the causative agent of Legionnaires' disease, infects and replicates in macrophages and amoebas. Following internalization, L. pneumophila resides in a vacuole structure called Legionella-containing vacuole (LCV)...
  5. doi Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions
    Tomoko Kubori
    The 21st Century COE Program, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Microbiol 67:1307-19. 2008
    b>Legionella pneumophila has a Dot/Icm type IV secretion system used to translocate a number of 'effector proteins' which subvert host cell functions...
  6. ncbi Legionella spp. and Legionnaires' disease
    B M W Diederen
    Regional Laboratory of Public Health Haarlem, Boerhaavelaan 26, 2035 RC Haarlem, The Netherlands
    J Infect 56:1-12. 2008
    Infection with Legionella spp. is an important cause of community- and hospital-acquired pneumonia, occurring both sporadically and in outbreaks. Infection with Legionella spp...
  7. pmc Legionella metaeffector exploits host proteasome to temporally regulate cognate effector
    Tomoko Kubori
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 6:e1001216. 2010
    ..b>Legionella LubX protein functions as an E3 ubiquitin ligase that hijacks the host proteasome to specifically target the ..
  8. ncbi The molecular ecology of legionellae
    B S Fields
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 4:286-90. 1996
    b>Legionella pneumophila is the most highly characterized member of a genus of bacteria that survive as intracellular parasites of freshwater protozoa...
  9. ncbi Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Nat Cell Biol 4:945-54. 2002
    It is unknown how Legionella pneumophila cells escape the degradative lysosomal pathway after phagocytosis by macrophages and replicate in an organelle derived from the endoplasmic reticulum. Here we show that, after internalization, L...
  10. doi The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water
    H Y Lau
    National Exposure Research Laboratory, U S Environmental Protection Agency, Cincinnati, OH 45268, USA
    J Appl Microbiol 107:368-78. 2009
    Current models to study Legionella pathogenesis include the use of primary macrophages and monocyte cell lines, various free-living protozoan species and murine models of pneumonia. However, there are very few studies of Legionella spp...
  11. doi Water quality parameters associated with prevalence of Legionella in hot spring facility water bodies
    Shih Wei Huang
    Department of Earth and Environmental Sciences, National Chung Cheng University, 168 University Road, Minhsiung Township, Chiayi County 62102, Taiwan, ROC
    Water Res 44:4805-11. 2010
    Some species of Legionella are recognized as opportunistic potential human pathogens, such as Legionella pneumophila, which causes legionnaires disease...
  12. doi Anti-Legionella activity of staphylococcal hemolytic peptides
    A Marchand
    Laboratoire de Chimie et Microbiologie de l Eau, UMR 6008 CNRS, IBMIG UFR Sciences Fondamentales et Appliquées, Universite de Poitiers, 1 rue du Georges Bonnet, 86022 Poitiers Cedex, France
    Peptides 32:845-51. 2011
    A collection of various Staphylococci was screened for their anti-Legionella activity. Nine of the tested strains were found to secrete anti-Legionella compounds...
  13. doi Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella spp. in clinical specimens using a single-tube multiplex real-time PCR assay
    Kathleen A Thurman
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Diagn Microbiol Infect Dis 70:1-9. 2011
    ..PCR assay for the detection of Mycoplasma pneumoniae (MP181), Chlamydia (Chlamydophila) pneumoniae (CP-Arg), Legionella spp...
  14. pmc The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies
    Robert Wrase
    Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 108:10490-5. 2011
    ..15-Å-resolution crystal structure of the second major chaperone-protease of the periplasm, DegQ from Legionella fallonii. DegQ assembles into large, cage-like 12-mers that form independently of unfolded substrate proteins...
  15. pmc Sequence-based classification scheme for the genus Legionella targeting the mip gene
    R M Ratcliff
    Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Clin Microbiol 36:1560-7. 1998
    The identification and speciation of strains of Legionella is often difficult, and even the more successful chromatographic classification techniques have struggled to discriminate newly described species...
  16. doi Compost facilities as a reservoir of Legionella pneumophila and other Legionella species
    S Casati
    Swiss National Reference Center for Legionella, Cantonal Institute of Microbiology, Bellinzona, Switzerland
    Clin Microbiol Infect 16:945-7. 2010
    ..Alternative ecosystems that could act as a reservoir for Legionella spp...
  17. pmc Isolation of Legionella anisa using an amoebic coculture procedure
    B La Scola
    , CNRS UPRESA 6020, , 13385 Marseille Cedex 05, France
    J Clin Microbiol 39:365-6. 2001
    ..However, coculture of a sputum sample with Acanthamoeba polyphaga amoebae led to the recovery of Legionella anisa...
  18. ncbi Detection of Legionella spp. and some of their amoeba hosts in floating biofilms from anthropogenic and natural aquatic environments
    Priscilla Declerck
    Laboratory of Aquatic Ecology, Department of Biology, Zoological Institute, Katholieke Universiteit Leuven, Charles Deberiotstraat 32, 3000 Leuven, Belgium
    Water Res 41:3159-67. 2007
    ..develop at the water-air interface and harbor numerous microorganisms, some of which are human pathogens like Legionella pneumophila. The presence of Legionella spp. and especially L. pneumophila in such biofilms was investigated...
  19. doi A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria
    Elena Degtyar
    Department of Molecular Microbiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cell Microbiol 11:1219-35. 2009
    b>Legionella pneumophila infects alveolar macrophages and protozoa through establishment of an intracellular replication niche...
  20. doi Legionella, protozoa, and biofilms: interactions within complex microbial systems
    Michael Taylor
    Department of Environmental Health, Flinders University of South Australia, P O Box 2100, Adelaide, South Australia 5001, Australia
    Microb Ecol 58:538-47. 2009
    Currently, the investigation of Legionella ecology falls into two distinct areas of research activity: (1) that Legionella multiply within water sources by parasitizing amoebic or ciliate hosts or (2) that Legionella grows extracellularly ..
  21. doi Rapid identification of Legionella spp. by MALDI-TOF MS based protein mass fingerprinting
    Valeria Gaia
    Cantonal Institute of Microbiology, Bellinzona, Switzerland
    Syst Appl Microbiol 34:40-4. 2011
    A set of reference strains representing 38 different Legionella species were submitted to Whole Cell Mass Spectrometry (WCMS) with MALDI-TOF...
  22. ncbi Comparison of ethidium monoazide and propidium monoazide for the selective detection of viable Legionella cells
    Bin Chang
    Department of Bacteriology I, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Jpn J Infect Dis 63:119-23. 2010
    ..study, we compared the abilities of EMA and PMA, together with real-time PCR, to specifically distinguish dead Legionella cells from viable cells...
  23. doi Legionella pollution in cooling tower water of air-conditioning systems in Shanghai, China
    H Lin
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
    J Appl Microbiol 106:606-12. 2009
    To determine Legionella pollution prevalence, describe the amount of Legionellae with respect to temperature in Shanghai cooling tower water (CTWs) in various types of public sites.
  24. pmc Contribution of amoebic coculture to recovery of Legionella isolates from respiratory samples: prospective analysis over a period of 32 months
    G Descours
    Universite de Lyon, Lyon, France
    J Clin Microbiol 50:1725-6. 2012
    We evaluated the contribution of amoebic coculture to the recovery of Legionella spp. from 379 respiratory samples. The sensitivity of axenic culture was 42.1%...
  25. pmc Rapid method for enumeration of viable Legionella pneumophila and other Legionella spp. in water
    Pilar Delgado-Viscogliosi
    Département Eaux et Environnement, Institut Pasteur de Lille, F 59019 Lille cedex, France
    Appl Environ Microbiol 71:4086-96. 2005
    A sensitive and specific method has been developed to enumerate viable L. pneumophila and other Legionella spp. in water by epifluorescence microscopy in a short period of time (a few hours). This method allows the quantification of L...
  26. pmc Purification and characterization of a UDP-glucosyltransferase produced by Legionella pneumophila
    Iouri Belyi
    Gamaleya Research Institute of Epidemiology and Microbiology, Moscow 123098, Russia
    Infect Immun 71:181-6. 2003
    b>Legionella pneumophila is the agent of Legionnaires' disease. It invades and replicates within eukaryotic cells, including aquatic protozoans, mammalian macrophages, and epithelial cells...
  27. ncbi Evidence for the presence of Legionella bacteriophages in environmental water samples
    Elke Lammertyn
    Laboratory for Bacteriology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven, Belgium
    Microb Ecol 56:191-7. 2008
    The existence and preliminary characterization of bacteriophages active against the Gram-negative human pathogen Legionella pneumophila, the causative agent of a very severe form of pneumonia, are reported...
  28. doi Isolation of Legionella-containing vacuoles by immuno-magnetic separation
    Simon Urwyler
    Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
    Curr Protoc Cell Biol . 2010
    The environmental bacterium Legionella pneumophila naturally parasitizes free-living amoebae. L...
  29. pmc Temperature-regulated formation of mycelial mat-like biofilms by Legionella pneumophila
    Zhenyu Piao
    Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Appl Environ Microbiol 72:1613-22. 2006
    Fifty strains representing 38 species of the genus Legionella were examined for biofilm formation on glass, polystyrene, and polypropylene surfaces in static cultures at 25 degrees C, 37 degrees C, and 42 degrees C...
  30. ncbi Infection due to Legionella species other than L. pneumophila
    Robert R Muder
    Infectious Diseases Section, VA Pittsburgh Healthcare System and University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
    Clin Infect Dis 35:990-8. 2002
    In addition to Legionella pneumophila, 19 Legionella species have been documented as human pathogens on the basis of their isolation from clinical material. Like L...
  31. pmc Quantitative real-time Legionella PCR for environmental water samples: data interpretation
    Philippe Joly
    Centre National de Référence des Legionella, INSERM E 0230, Faculte de Medecine, IFR 62, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Appl Environ Microbiol 72:2801-8. 2006
    Quantitative Legionella PCRs targeting the 16S rRNA gene (specific for the genus Legionella) and the mip gene (specific for the species Legionella pneumophila) were applied to a total of 223 hot water system samples (131 in one laboratory ..
  32. pmc Legionella species colonization of water distribution systems, pools and air conditioning systems in cruise ships and ferries
    Georgia Goutziana
    Department of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece
    BMC Public Health 8:390. 2008
    ..This study was scheduled in order to investigate Legionella spp...
  33. ncbi Comparative assessment of virulence traits in Legionella spp
    O A Terry Alli
    Department of Microbiology and Immunology, College of Medicine, University of Kentucky, Chandler Medical Center, Lexington, KY 40503, USA
    Microbiology 149:631-41. 2003
    b>Legionella pneumophila is a facultative intracellular pathogen that accounts for the majority of cases of Legionnaires' disease in the USA and Europe, but other Legionella spp. have been shown to cause disease...
  34. pmc Development and evaluation of Chlamylege, a new commercial test allowing simultaneous detection and identification of Legionella, Chlamydophila pneumoniae, and Mycoplasma pneumoniae in clinical respiratory specimens by multiplex PCR
    C Ginevra
    Laboratoire de Bacteriologie virologie, GIMAP, Faculte de Medecine Jacques Lisfranc, Saint Etienne, France
    J Clin Microbiol 43:3247-54. 2005
    ..the simultaneous detection in respiratory samples of Chlamydophila pneumoniae, Mycoplasma pneumoniae, and most Legionella species, as well as PCR inhibitors, by using a multiplex PCR and microplate hybridization...
  35. pmc Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    Natalie N Whitfield
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:423-32. 2010
    b>Legionella pneumophila, a motile opportunistic pathogen of humans, is restricted from replicating in the lungs of C57BL/6 mice. Resistance of mouse macrophages to L. pneumophila depends on recognition of cytosolic flagellin...
  36. doi Detection of culturable and nonculturable Legionella species from hot water systems of public buildings in Japan
    A Edagawa
    Department of Environment and Water, Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka, Japan
    J Appl Microbiol 105:2104-14. 2008
    To investigate the prevalence of culturable and nonculturable Legionella species in hot water systems of public buildings in Japan and assess the risk factors associated with Legionella contamination in hot water systems.
  37. ncbi Legionella in clinical specimens and hospital water supply facilities: molecular detection and genotyping of the isolates
    J A Qasem
    Department of Applied Medical Sciences, College of Health Sciences, The Public Authority for Applied Education and Training, Kuwait University, Kuwait
    Med Princ Pract 17:49-55. 2008
    To evaluate genus- and species-specific polymerase chain reactions (PCRs) for the detection of the genus Legionella and the species Legionella pneumophila in clinical specimens and hospital water supplies, and to establish a simple and ..
  38. ncbi Legionella drancourtii sp. nov., a strictly intracellular amoebal pathogen
    Bernard La Scola
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterrannee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Syst Evol Microbiol 54:699-703. 2004
    A Legionella-like amoebal pathogen (LLAP), formerly named LLAP12(T), was characterized on the basis of microscopic appearance, staining characteristics, growth in Acanthamoeba polyphaga at different temperatures, DNA G+C content, ..
  39. pmc Surface translocation by Legionella pneumophila: a form of sliding motility that is dependent upon type II protein secretion
    Catherine R Stewart
    Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Bacteriol 191:1537-46. 2009
    b>Legionella pneumophila exhibits surface translocation when it is grown on a buffered charcoal yeast extract (BCYE) containing 0.5 to 1.0% agar...
  40. pmc Molecular survey of the occurrence of Legionella spp., Mycobacterium spp., Pseudomonas aeruginosa, and amoeba hosts in two chloraminated drinking water distribution systems
    Hong Wang
    Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA
    Appl Environ Microbiol 78:6285-94. 2012
    ..The purpose of this study was to identify patterns of occurrence among three opportunistic pathogens (Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa) relative to biotic and abiotic factors in two ..
  41. pmc Contamination of Qiagen DNA extraction kits with Legionella DNA
    Gloria E Evans
    J Clin Microbiol 41:3452-3. 2003
  42. ncbi Bathwater-associated cases of legionellosis in Japan, with a special focus on Legionella concentrations in water
    Toshiro Kuroki
    Department of Microbiology, Kanagawa Prefectural Institute of Public Health, Kanagawa 253 0087, Japan
    Jpn J Infect Dis 62:201-5. 2009
    To evaluate the relationship between the incidence of legionellosis and Legionella concentrations in bathwater, we sent a questionnaire to 76 prefectural and municipal public health laboratories in Japan and found that 35 had encountered ..
  43. doi Evaluation of different nucleic acid amplification techniques for the detection of M. pneumoniae, C. pneumoniae and Legionella spp. in respiratory specimens from patients with community-acquired pneumonia
    K Loens
    Department of Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp UIA, Antwerp, Belgium
    J Microbiol Methods 73:257-62. 2008
    ..pneumoniae, C. pneumoniae and Legionella spp. in respiratory specimens from hospitalized and outpatients with community-acquired pneumonia (CAP)...
  44. pmc Presence and persistence of Legionella spp. in groundwater
    Joana Costa
    Departamento de Zoologia and Centro de Neurociências e Biologia Celular, Universidade de Coimbra, 3004 517 Coimbra, Portugal
    Appl Environ Microbiol 71:663-71. 2005
    ..The number of Legionella isolates detected was generally low...
  45. pmc Legionella species diversity in an acidic biofilm community in Yellowstone National Park
    Kathy B Sheehan
    Department of Microbiology and the Thermal Biology Institute, Montana State University, Bozeman, MT 59717 3080, USA
    Appl Environ Microbiol 71:507-11. 2005
    b>Legionella species are frequently detected in aquatic environments, but their occurrence in extreme, acidic, geothermal habitats has not been explored with cultivation-independent methods...
  46. pmc Occurrence and genetic diversity of uncultured Legionella spp. in drinking water treated at temperatures below 15 degrees C
    Bart A Wullings
    Kiwa Water Research, Groningenhaven 7, P O Box 1072, 3430 BB Nieuwegein, The Netherlands
    Appl Environ Microbiol 72:157-66. 2006
    Representatives of the genus Legionella were detected by use of a real-time PCR method in all water samples collected directly after treatment from 16 surface water (SW) supplies prior to postdisinfection and from 81 groundwater (GW) ..
  47. pmc Distribution of Legionella species from environmental water sources of public facilities and genetic diversity of L. pneumophila serogroup 1 in South Korea
    Hae Kyung Lee
    Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention, Seoul, Republic of Korea
    Appl Environ Microbiol 76:6547-54. 2010
    A total of 560 Legionella species were isolated from environmental water sources from public facilities from June to September 2008 throughout South Korea...
  48. pmc Detection of Legionella species in respiratory specimens using PCR with sequencing confirmation
    J L Cloud
    Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA
    J Clin Microbiol 38:1709-12. 2000
    b>Legionella spp. are a common cause of community-acquired respiratory tract infections and an occasional cause of nosocomial pneumonia...
  49. pmc Protein LidA from Legionella is a Rab GTPase supereffector
    Stefan Schoebel
    Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, Dortmund 44227, Germany
    Proc Natl Acad Sci U S A 108:17945-50. 2011
    The causative agent of Legionnaires disease, Legionella pneumophila, injects several hundred proteins into the cell it infects, many of which interfere with or exploit vesicular transport processes...
  50. pmc Isolation of an amoeba naturally harboring a distinctive Legionella species
    A L Newsome
    Department of Biology, Middle Tennessee State University, Murfreesboro 37132, USA
    Appl Environ Microbiol 64:1688-93. 1998
    There are numerous in vitro studies documenting the multiplication of Legionella species in free-living amoebae and other protozoa...
  51. ncbi Non-touch fittings in hospitals: a possible source of Pseudomonas aeruginosa and Legionella spp
    M Halabi
    Department of Pathology and Microbiology, Infection Control Team, Krankenhaus der Barmherzigen Schwestern Ried im Innkreis, A 4910 Ried im Innkreis, Austria
    J Hosp Infect 49:117-21. 2001
    ..In 10 non-touch taps without temperature selection, the authors also screened for Legionella spp. in 500 ml water samples...
  52. doi Effectiveness of different methods to control legionella in the water supply: ten-year experience in an Italian university hospital
    I Marchesi
    Department of Public Health Sciences, University of Modena and Reggio Emilia, Italy
    J Hosp Infect 77:47-51. 2011
    ..thermal shock, chlorine dioxide, monochloramine, boilers and point-of-use filters for controlling legionella contamination in a hospital hot water distribution system...
  53. ncbi [The occurrence of legionella in dental units and the consequences for practice hygiene]
    M Borneff
    Hygiene Institut, Universitat Heidelberg, Abt Hygiene und Med Mikrobiologie
    Zentralbl Bakteriol Mikrobiol Hyg B 187:295-311. 1989
    ....
  54. ncbi Identification methods for Legionella from environmental samples
    C Bartie
    Immunology and Microbiology Section, National Centre for Occupational Health, P O Box 4788, Johannesburg, 2000, South Africa
    Water Res 37:1362-70. 2003
    Laboratories responsible for Legionella diagnostics around the world use a number of different culturing methods of non-equivalent sensitivities and specificities, to detect Legionella species in environmental samples...
  55. doi Electrochemically amplified molecular beacon biosensor for ultrasensitive DNA sequence-specific detection of Legionella sp
    Varun Rai
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, 21 Nanyang Link, Nanyang Technological University, Singapore 637171, Singapore
    Biosens Bioelectron 32:133-40. 2012
    ..Its applicability is tested against PCR amplicons derived from genomic DNA of live Legionella pneumophila. Excellent specificity down to one and three nucleotides mismatches in another strain of L...
  56. pmc Multiplication of Legionella spp. in tap water containing Hartmannella vermiformis
    R M Wadowsky
    Department of Pathology, School of Medicine, University of Pittsburg, Pennsylvania
    Appl Environ Microbiol 57:1950-5. 1991
    A model was developed to study the multiplication of various Legionella spp. in tap water containing Hartmannella vermiformis...
  57. doi Comparison of potentially pathogenic free-living amoeba hosts by Legionella spp. in substrate-associated biofilms and floating biofilms from spring environments
    Bing Mu Hsu
    Department of Earth and Environmental Sciences, National Chung Cheng University, 168 University Road, Minhsiung Township, Chiayi County 62102, Taiwan, ROC
    Water Res 45:5171-83. 2011
    This study compares five genera of free-living amoebae (FLA) hosts by Legionella spp. in the fixed and floating biofilm samples from spring environments. Detection rate of Legionella spp. was 26.9% for the floating biofilms and 3...
  58. ncbi Legionella prevalence in hot spring recreation areas of Taiwan
    Bing Mu Hsu
    Department of Earth and Environmental Sciences, National Chung Cheng University, Chiayi, Taiwan, ROC
    Water Res 40:3267-73. 2006
    b>Legionella is a bacterium ubiquitous to aquatic environments. Within the genus a few species are recognized as opportunistic potential human pathogens, especially the species Legionella pneumophila, which causes pneumonia legionellosis...
  59. ncbi Morphological variety of intracellular microcolonies of Legionella species in Vero cells
    M Ogawa
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Microbiol Immunol 45:557-62. 2001
    Intracellular microcolonies of six Legionella species growing in Vero cells showed distinctly varied morphologies...
  60. doi Application of EMA-qPCR as a complementary tool for the detection and monitoring of Legionella in different water systems
    Tian Qin
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No 155, Changbai Road, Changping, Beijing 102206, People s Republic of China
    World J Microbiol Biotechnol 28:1881-90. 2012
    b>Legionella are prevalent in human-made water systems and cause legionellosis in humans...
  61. doi Survey of Naegleria and its resisting bacteria-Legionella in hot spring water of Taiwan using molecular method
    Shih Wei Huang
    Department of Earth and Environmental Sciences, National Chung Cheng University, 168, University Rd, Min Hsiung, Chiayi, Taiwan, Republic of China
    Parasitol Res 106:1395-402. 2010
    ..Furthermore, the Naegleria spp. can serve as vehicles for facultative pathogens, such as Legionella. In this study, we identified Naegleria and Legionella based on the PCR amplification with a genus-specific ..
  62. doi Cellular envelope phospholipids from Legionella lytica
    Marta Palusinska-Szysz
    Department of General Microbiology, Maria Curie Sklodowska University, Akademicka St 19, Lublin, Poland
    FEMS Microbiol Lett 283:239-46. 2008
    The composition of phospholipids from the cellular envelope of Legionella lytica grown on artificial medium was determined by two-dimensional thin-layer chromatography...
  63. doi Design and implementation of a protocol for the detection of Legionella in clinical and environmental samples
    Elizabeth J Nazarian
    Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    Diagn Microbiol Infect Dis 62:125-32. 2008
    Our laboratory has developed a novel real-time polymerase chain reaction (PCR) assay for the detection of Legionella pneumophila and differentiation from other Legionella spp. in clinical and environmental samples...
  64. pmc Detection of Legionella by quantitative-polymerase chain reaction (qPCR) for monitoring and risk assessment
    Louise H Krøjgaard
    Dept of Microbiological Surveillance and Research, Statens Serum Institut, Ørestads Boulevard 5, Copenhagen S, Denmark
    BMC Microbiol 11:254. 2011
    Culture and quantitative polymerase chain reaction (qPCR) assays for the detection of Legionella were compared on samples from a residential area before and after two interventions...
  65. pmc Serum cytokines in patients with Legionella pneumonia: relative predominance of Th1-type cytokines
    K Tateda
    Department of Microbiology, Toho University School of Medicine, Tokyo, Japan
    Clin Diagn Lab Immunol 5:401-3. 1998
    Serum samples from 14 patients with Legionella pneumonia were examined for the presence of cytokines...
  66. pmc High diversity and abundance of Legionella spp. in a pristine river and impact of seasonal and anthropogenic effects
    N Parthuisot
    UPMC Univ Paris 06, UMR 7621, Lomic, Observatoire Oceanologique, F 66650 Banyuls sur Mer, France
    Appl Environ Microbiol 76:8201-10. 2010
    The diversity and dynamics of Legionella species along a French river watershed subject to different thermal and wastewater discharges during an annual cycle were assessed by 16S rRNA gene sequencing and by a fingerprint technique, single-..
  67. ncbi Prevalence of Legionella spp. in swimming pool environment
    E Leoni
    Department of Medicine and Public Health, University of Bologna, Italy
    Water Res 35:3749-53. 2001
    A study was carried out to evaluate the prevalence of bacteria of the Legionella genus in the water from the pools and showers of 12 swimming pools in the city of Bologna (Italy)...
  68. pmc Enumeration of Legionella CFU by colony hybridization using specific DNA probes
    Wakako Satoh
    Technology and Development Laboratory, Kurita Water Industries Ltd, Kanagawa 243 0124, Japan
    Appl Environ Microbiol 68:6466-70. 2002
    Oligonucleotide probes and colony hybridization (CH) were applied to enumerate organisms of the genus Legionella in cooling tower water...
  69. pmc Qiagen DNA extraction kits for sample preparation for legionella PCR are not suitable for diagnostic purposes
    Anneke van der Zee
    J Clin Microbiol 40:1126. 2002
  70. doi Electrochemical nanoporous alumina membrane-based label-free DNA biosensor for the detection of Legionella sp
    Varun Rai
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, 21 Nanyang Link, Nanyang Technological University, Singapore 637371, Singapore
    Talanta 98:112-7. 2012
    ..from target sequences with single base mismatch (MM1) and triple bases mismatch (MM3) of different strain of Legionella sp...
  71. ncbi [Distribution of Legionella spp. in hot spring baths in Japan]
    Katsunori Furuhata
    College of Environmental Health, Azabu University
    Kansenshogaku Zasshi 78:710-6. 2004
    We investigated the inhabitation of Legionella spp. in hot spring water in various regions in Japan. The following results were obtained. 1) Of 710 hot spring water samples nationwide, Legionella spp. was isolated from 204 samples (28...
  72. ncbi Co-existence of Legionella and other Gram-negative bacteria in potable water from various rural and urban sources
    Nimfa Maria Stojek
    Department of Water and Soil Safety, Institute of Rural Health, Lublin, Poland
    Ann Agric Environ Med 18:330-4. 2011
    ..Water samples were examined for the presence and species composition of Legionella, Yersinia, Gram-negative bacteria belonging to family Enterobacteriaceae (GNB-E) and Gram-negative bacteria not ..
  73. pmc Concentration and diversity of uncultured Legionella spp. in two unchlorinated drinking water supplies with different concentrations of natural organic matter
    Bart A Wullings
    KWR Watercycle Research Institute, Nieuwegein, Netherlands
    Appl Environ Microbiol 77:634-41. 2011
    ..were investigated to assess the potential of water treatment and distribution systems to support the growth of Legionella spp. The treatment plant for supply A distributed treated groundwater with a low concentration (<0...
  74. pmc Relationships between free-living protozoa, cultivable Legionella spp., and water quality characteristics in three drinking water supplies in the Caribbean
    Rinske M Valster
    KWR Watercycle Research Institute, Groningenhaven 7, P O Box 1072, 3430 BB Nieuwegein, The Netherlands
    Appl Environ Microbiol 77:7321-8. 2011
    ..at identifying free-living protozoa (FLP) and conditions favoring the growth of these organisms and cultivable Legionella spp. in drinking water supplies in a tropical region...
  75. doi Legionella species colonization in cooling towers: risk factors and assessment of control measures
    Varvara A Mouchtouri
    Department of Hygiene and Epidemiology, Medical School, University of Thessaly, Larissa, Greece
    Am J Infect Control 38:50-5. 2010
    Cooling towers can be colonized by Legionella spp, and inhalation of aerosols generated by their operation may cause Legionnaires' disease in susceptible hosts...
  76. pmc Legionella confirmation using real-time PCR and SYTO9 is an alternative to current methodology
    Steven Giglio
    Australian Water Quality Centre, PMB 3, Salisbury, South Australia 5108, Australia
    Appl Environ Microbiol 71:8944-8. 2005
    The currently accepted culture techniques for the detection of Legionella spp. in water samples (AS/NZS 3896:1998 and ISO 11731 standard methods) are slow and laborious, requiring from 7 to 14 days for a result...
  77. ncbi Extrapulmonary Legionella micdadei infection in a previously healthy child
    Xuan Qin
    Department of Laboratories and Pathology, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Infect Dis J 21:1174-6. 2002
    ..Surgical drainage specimens from the mass were bacterial culture-negative. Legionella micdadei infection was diagnosed by a two step PCR-nucleic acid sequencing method and supported by organism-..
  78. doi Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia
    Heike von Baum
    Institute for Medical Microbiology and Hygiene, University Hospital of Ulm, Germany
    Clin Infect Dis 46:1356-64. 2008
    ..The Competence Network for Community Acquired Pneumonia (CAPNETZ) offers a unique opportunity to study the epidemiology of legionellosis throughout Germany, applying sophisticated diagnostic tools...
  79. ncbi Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testing
    Janet E Stout
    VA Pittsburgh Healthcare System, VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
    Int J Antimicrob Agents 25:302-7. 2005
    ..and telithromycin) and macrolides (clarithromycin, azithromycin and erythromycin) were evaluated against Legionella pneumophila by broth dilution and an HL-60 intracellular model...
  80. ncbi Phylogenetic study of legionella species in pristine and polluted aquatic samples from a tropical Atlantic forest ecosystem
    Fábio R S Carvalho
    Laboratory of Environmental Microbiology, Department of Microbiology, Institute of Biomedical Science, University of Sao Paulo, Room 148 Lineu Prestes avenue, 1374, Cidade Universitária São Paulo, SP, Brazil
    Curr Microbiol 55:288-93. 2007
    b>Legionella species are ubiquitous bacteria in aquatic environments...
  81. ncbi Development of conventional and real-time NASBA for the detection of Legionella species in respiratory specimens
    K Loens
    Department of Microbiology, University of Antwerp UA, Antwerp, Belgium
    J Microbiol Methods 67:408-15. 2006
    Isothermal nucleic acid sequence-based amplification (NASBA) was applied to detect Legionella 16S rRNA...
  82. ncbi Prevalence of legionella waterline contamination and Legionella pneumophila antibodies in general dental practitioners in London and rural Northern Ireland
    C L Pankhurst
    Division of Oral Medicine, Guy s, King s St Thomas Dental Institute, Guy s Campus, London SE 9RT
    Br Dent J 195:591-4; discussion 581. 2003
    ....
  83. ncbi Comparison of three Legionella urinary antigen assays during an outbreak of legionellosis in Belgium
    Kristien Dirven
    Laboratory of Medical Microbiology, University of Antwerp UA, Wilrijk, Belgium
    J Med Microbiol 54:1213-6. 2005
    During an outbreak of legionellosis in Belgium, urine samples of 32 legionellosis patients were tested with three Legionella urinary antigen assays: the Biotest enzyme immunoassay (EIA) kit, the Binax EIA kit and the Binax NOW ..
  84. ncbi Literature review--efficacy of various disinfectants against Legionella in water systems
    B R Kim
    Ford Research Laboratory, Dearborn, MI 48121, USA
    Water Res 36:4433-44. 2002
    ..and implementing such a measure at its facilities worldwide to provide technical guidance for controlling Legionella in water systems...
  85. pmc Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells
    P S Hoffman
    Department of Microbiology and Immunology, University of Tennessee, Memphis 38163
    Infect Immun 58:3380-7. 1990
    A 60-kilodalton (kDa) immunodominant antigen of Legionella pneumophila is a heat shock protein (HSP) of the GroEL class of HSPs. The gene (htpB) coding the 60-kDa protein was localized to a 3.2-kilobase DNA fragment of L...
  86. pmc Australian isolates of Legionella longbeachae are not a clonal population
    J C Montanaro-Punzengruber
    Department of Medicine, University of Sydney, New South Wales 2006, Australia
    J Clin Microbiol 37:3249-54. 1999
    b>Legionella longbeachae is almost as frequent a cause of legionellosis in Australia as Legionella pneumophila, but epidemiological investigation of possible environmental sources and clinical cases has been limited by the lack of a ..
  87. doi Effects of chemically and electrochemically dosed chlorine on Escherichia coli and Legionella beliardensis assessed by flow cytometry
    Yingying Wang
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Appl Microbiol Biotechnol 87:331-41. 2010
    ..and electrochemically dosed chlorine on two models for typical water-borne bacteria (Escherichia coli and Legionella beliardensis) by plating and flow cytometry (FCM) in combination with different fluorescence dyes...
  88. ncbi Chemical structure and biological significance of lipopolysaccharide from Legionella
    Marta Palusinska-Szysz
    Department of Genetics and Microbiology, Maria Curie Skłodowska University, Lublin, Poland
    Recent Pat Antiinfect Drug Discov 4:96-107. 2009
    b>Legionella are aerobic, gram-negative, motile, rod-shaped bacteria, which form a distinct taxonomic unit within the gamma - 2 subdivision of the Proteobacteria...
  89. doi Legionella bozemanae synthesizes phosphatidylcholine from exogenous choline
    Marta Palusinska-Szysz
    Department of Genetics and Microbiology, Institute of Microbiology and Biotechnology, Maria Curie Sklodowska University, Akademicka St 19, PL 20 033 Lublin, Poland
    Microbiol Res 166:87-98. 2011
    The phospholipid class and fatty acid composition of Legionella bozemanae were determined using thin-layer chromatography, gas-liquid chromatography, and matrix-assisted laser desorption ionization-time of flight mass spectrometry...
  90. doi First isolation of Legionella species, including L. pneumophila serogroup 1, in Greek potting soils: possible importance for public health
    E N Velonakis
    Department of Microbiology, National School of Public Health and Central Public Health Laboratory, Athens Hellenic Centre for Infectious Disease Control KEELPNO, Ministry of Health, Athens, Greece
    Clin Microbiol Infect 16:763-6. 2010
    A total of 21 Legionella isolates were recovered from six out of 22 samples of potting soil from the Athens area, Greece. Legionella pneumophila (serogroups 1 and 2-15) and species and serotypes included in the group of L...
  91. ncbi Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp
    J Dubois
    Novabyss Inc, Centre universitaire de sante de l Estrie, 614 rue Bowen Sud, Sherbrooke, Québec J1G 2E9, Canada
    J Antimicrob Chemother 45:41-6. 2000
    ..ofloxacin, ciprofloxacin, azithromycin, clarithromycin, erythromycin and rifampicin were evaluated against Legionella pneumophila serogroups 1-9 and 12 (n = 204) and other Legionella spp. (n = 34)...
  92. doi Free-living amoebae, Legionella and Mycobacterium in tap water supplied by a municipal drinking water utility in the USA
    Francine Marciano-Cabral
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Water Health 8:71-82. 2010
    b>Legionella and Mycobacterium can proliferate within free-living amoebae (FLA) where they are protected from disinfectants at concentrations that can kill bacteria but not protozoa...
  93. pmc Evaluation of the Binax and Biotest urinary antigen kits for detection of Legionnaires' disease due to multiple serogroups and species of Legionella
    R F Benson
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2763-5. 2000
    ..and the Biotest urinary antigen kits for the detection of Legionnaires' disease caused by organisms other than Legionella pneumophila were compared by testing 45 urine samples from non-Legionella pneumophila serogroup 1 patients ..
  94. pmc Recurrent soft tissue abscesses caused by Legionella cincinnatiensis
    J G Gubler
    Department of Medicine, Stadtspital Triemli, CH 8063 Zurich, Switzerland
    J Clin Microbiol 39:4568-70. 2001
    ..Broad-spectrum PCR revealed Legionella cincinnatiensis, which was confirmed by isolation of the organism on special Legionella medium...
  95. doi Commercial potting soils as an alternative infection source of Legionella pneumophila and other Legionella species in Switzerland
    S Casati
    Swiss National Reference Centre for Legionella, Cantonal Institute of Microbiology, Bellinzona, Switzerland
    Clin Microbiol Infect 15:571-5. 2009
    b>Legionella spp. are pathogens that can cause Legionnaires' disease in humans through inhalation of contaminated aerosols. The principal reservoir for these microorganisms is water, but Legionella spp...
  96. doi Pneumonia due to Legionella feeleii: case report and review of the literature
    J Lee
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Transpl Infect Dis 11:337-40. 2009
    b>Legionella feeleii is a rare cause of community-acquired pneumonia that occurs in immunocompromised hosts who are often receiving corticosteroid therapy...
  97. pmc Application of RNA polymerase beta-subunit gene (rpoB) sequences for the molecular differentiation of Legionella species
    Kwan Soo Ko
    Department of Microbiology and Cancer Research Institute, Institute of Endemic Diseases, SNUMRC, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Seoul 110 799
    J Clin Microbiol 40:2653-8. 2002
    The nucleotide sequences of the partial rpoB gene were determined from 38 Legionella species, including 15 serogroups of Legionella pneumophila...
  98. pmc Legionella spp. and legionellosis in southeastern Italy: disease epidemiology and environmental surveillance in community and health care facilities
    Christian Napoli
    Department of Biomedical Science and Human Oncology Hygiene section, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    BMC Public Health 10:660. 2010
    ..The aim of the study is to identify the risk factors for the disease, so allowing better programming of the necessary prevention measures...
  99. pmc Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen
    J S Sampson
    Division of Bacterial Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    Infect Immun 58:3154-7. 1990
    Gene htpB, which encodes the 58-kilodalton protein of Legionella pneumophila, was cloned in Escherichia coli and its complete nucleotide sequence was determined...
  100. pmc Influence of Acanthamoeba castellanii on intracellular growth of different Legionella species in human monocytes
    B Neumeister
    Abteilung Transfusionsmedizin, Universitatsklinikum Tubingen, 72076 Tubingen, Germany
    Appl Environ Microbiol 66:914-9. 2000
    Previous studies using a murine model of coinhalation of Legionella pneumophila and Hartmannella vermiformis have shown a significantly enhanced intrapulmonary growth of L. pneumophila in comparison to inhalation of legionellae alone (J...
  101. pmc A specific genomic location within the icm/dot pathogenesis region of different Legionella species encodes functionally similar but nonhomologous virulence proteins
    Michal Feldman
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Infect Immun 72:4503-11. 2004
    b>Legionella pneumophila, the major causative agent of Legionnaires' disease, is a facultative intracellular pathogen that grows within human macrophages and amoebae...

Research Grants86

  1. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas Cianciotto; Fiscal Year: 2009
    b>Legionella pneumophila (Lp) is the primary agent of Legionnaires' disease, a common and potentially fatal form of pneumonia...
  2. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas P Cianciotto; Fiscal Year: 2010
    b>Legionella pneumophila (Lp) is the primary agent of Legionnaires'disease, a common and potentially fatal form of pneumonia...
  3. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward Shaw; Fiscal Year: 2007
    ..Mile Phase I strain) has been sequenced and contains genes homologous to the type IV secretion system (TFSS) of Legionella pneumophila, suggesting that C...
  4. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2010
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  5. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  6. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    ..In this proposal, we focus on Legionella pneumophila (Lp), as our preliminary data show that the in vivo depletion of CXCL5, but not other neutrophilic ..
  7. The function of RickA and host factors in Rickettsia actin based motility
    ALISA SERIO; Fiscal Year: 2007
    ..To determine whether RickA is translocated by the TFSS, RickA will be expressed in Legionella pneumophila and its ability to be translocated by the L...
  8. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
    ..Some structural features of/?, leguminosarum lipid A are seen in human pathogens. Legionella pneumophila lipid A i contains a C28 chain, while Porphyromonas gingivalis and Helicobacter pylori lipid A lack ..
  9. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2007
    ..The genera we will focus on include agents of lung, cutaneous, and tissue infections (Mycobacterium, Nocardia, Legionella), microaerophilic gastro-intestinal pathogens (Helicobacter, Campylobacter, Arcobacter, Wolinella), and ..
  10. Legionella pneumophila developmental cycle & virulence
    Paul Hoffman; Fiscal Year: 2007
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires' disease...
  11. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2009
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  12. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  13. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  14. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2007
    ..to a number of intracellular pathogens that form chronic infections such as species of Brucella, Bartonella, Legionella, as well as Francisella...
  15. Legionella pneumophila developmental cycle & virulence
    Paul Hoffman; Fiscal Year: 2009
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires' disease...
  16. Role of caspases in Legionella pneumophila pulmonary infection
    Amal Amer; Fiscal Year: 2009
    Role of caspases in Legionella pneumophila pulmonary infection. Legionella pneumophila (L...
  17. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    b>Legionella pneumophila (L. pneumophila) resides in aquatic habitats as an intracellular parasite of protozoa and when transmitted in aerosols to susceptible humans, produces an acute pneumonia known as Legionnaires'disease...
  18. Role of caspases in Legionella pneumophila pulmonary infection
    Amal O Amer; Fiscal Year: 2010
    Role of caspases in Legionella pneumophila pulmonary infection. Legionella pneumophila (L...
  19. Salmonella evasion of NADPH oxidase-dependent killing
    Andres Vazquez Torres; Fiscal Year: 2007
    ..oxidase but will also identify potential molecular targets common to intracellular pathogens such as Salmonella, Mycobacterium, and Legionella that are capable of thwarting the normal maturation of the nascent phagosome.
  20. Gene Expression Patterns and Lifestyles in Legionella
    Howard Shuman; Fiscal Year: 2009
    b>Legionella pneumophila, the gram-negative species that causes legionnaires' disease and other acute respiratory diseases, replicates within a wide range of phagocytic host cells. During legionnaires' disease, L...
  21. Gene Expression Patterns and Lifestyles in Legionella
    Howard Shuman; Fiscal Year: 2007
    b>Legionella pneumophila, the gram-negative species that causes legionnaires' disease and other acute respiratory diseases, replicates within a wide range of phagocytic host cells. During legionnaires' disease, L...
  22. GENETIC DETERMINANTS OF PATHOGENICITY IN LEGIONELLA
    Lucy Tompkins; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Legionella pneumophila is a facultative intracellular pathogen that grows inside protozoans in fresh water sources...
  23. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2007
    ..tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, Staphylococcus aureus and Bacillus anthracis)...
  24. GENETIC DETERMINANT OF PATHOGENICITY IN LEGIONELLA
    Lucy Tompkins; Fiscal Year: 1993
    DESCRIPTION: (Adapted from applicant's abstract). Legionella pneumophila, the agent of Legionnaire's disease, causes a significant proportion of both community-acquired and nosocomial pneumonia in the U.S. each year...
  25. Macrophage transcriptional responses to Legionella pneumophila
    RUSSELL VANCE; Fiscal Year: 2009
    b>Legionella pneumophila is a protypical example of an emerging infectious disease threat...
  26. Facility Airborne Biological Toxin Alarm System
    John Parrish; Fiscal Year: 2005
    ..system will detect more routine threats to indoor lealth such as molds and fungi (Aspergillus) and bacteria (Legionella)...
  27. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004
    Description (Adapted from applicant's abstract): The ability of Legionella pneumophila (Lpn) to cause pneumonia is dependent on intracellular replication within pulmonary phagocytic and epithelial cells...
  28. Macrophage transcriptional responses to Legionella pneumophila
    Russell E Vance; Fiscal Year: 2010
    b>Legionella pneumophila is a protypical example of an emerging infectious disease threat...
  29. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis Lopatin; Fiscal Year: 2009
    ..it has been shown that protective response to stress proteins may be involved in control of diseases like IBD, Legionella, Yersinia, Chlamydia and H. pylori infections and arteriosclerosis...
  30. Type IV Secretion Systems in Legionella pneumophila
    HOWARD STEINMAN; Fiscal Year: 2009
    b>Legionella pneumophila, the causative organism of Legionnaires' disease, is a fresh water bacterium that can invade amoebae and macrophages and replicate in membrane bound phagosomes...
  31. Type IV Secretion Systems in Legionella pneumophila
    HOWARD STEINMAN; Fiscal Year: 2007
    b>Legionella pneumophila, the causative organism of Legionnaires' disease, is a fresh water bacterium that can invade amoebae and macrophages and replicate in membrane bound phagosomes...