neisseria gonorrhoeae

Summary

Summary: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.

Top Publications

  1. ncbi Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 11:1074-87. 2009
  2. ncbi Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
  3. ncbi Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
    H J Tseng
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Microbiol 40:1175-86. 2001
  4. ncbi Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
    Hong Wu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, USA
    Infect Immun 74:4094-103. 2006
  5. ncbi Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    W M Shafer
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 95:1829-33. 1998
  6. ncbi Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
    S Ram
    Evans Biomedical Research Center, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Exp Med 193:281-95. 2001
  7. ncbi Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay
    Kate L Seib
    The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Infect Immun 73:5269-72. 2005
  8. ncbi A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cell Microbiol 4:571-84. 2002
  9. ncbi Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes
    Mark P Simons
    Department of Microbiology, 3-403 Bowen Science Building, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Infect Immun 73:1971-7. 2005
  10. ncbi Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    B Feinen
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    Mucosal Immunol 3:312-21. 2010

Research Grants

  1. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 2001
  2. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2010
  3. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2009
  4. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
  5. PENICILLIN RESISTANT NEISSERIA GONORRHOEAE (CMRNG)
    Robert Nicholas; Fiscal Year: 2000
  6. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1993
  7. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
  8. Type IV secretion by Neisseria gonorrhoeae
    JOSEPH DILLARD; Fiscal Year: 2005
  9. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2010
  10. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003

Detail Information

Publications263 found, 100 shown here

  1. ncbi Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 11:1074-87. 2009
    Symptomatic infection with Neisseria gonorrhoeae (Gc) is characterized by abundant neutrophil (PMN, polymorphonuclear leucocyte) influx, but PMNs cannot clear initial infection, indicating that Gc possess defences against PMN challenge...
  2. ncbi Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
    ..These studies establish a hierarchy of mtrR locus mutations with regard to regulation of pump efflux, and suggest selection for more derepressed mutants may occur during mixed infections...
  3. ncbi Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
    H J Tseng
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Microbiol 40:1175-86. 2001
    As a facultative aerobe with a high iron requirement and a highly active aerobic respiratory chain, Neisseria gonorrhoeae requires defence systems to respond to toxic oxygen species such as superoxide...
  4. ncbi Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
    Hong Wu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, USA
    Infect Immun 74:4094-103. 2006
    The addition of host-derived sialic acid to Neisseria gonorrhoeae lipooligosaccharide is hypothesized to be an important mechanism by which gonococci evade host innate defenses...
  5. ncbi Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    W M Shafer
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 95:1829-33. 1998
    ..capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-..
  6. ncbi Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
    S Ram
    Evans Biomedical Research Center, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Exp Med 193:281-95. 2001
    We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp)...
  7. ncbi Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay
    Kate L Seib
    The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Infect Immun 73:5269-72. 2005
    b>Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N...
  8. ncbi A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cell Microbiol 4:571-84. 2002
    ..In conjunction, these molecules facilitate targeting to and successful infection of the cervical epithelium...
  9. ncbi Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes
    Mark P Simons
    Department of Microbiology, 3-403 Bowen Science Building, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Infect Immun 73:1971-7. 2005
    b>Neisseria gonorrhoeae causes severe exudative urethritis. The exudates from infected individuals contain large numbers of polymorphonuclear leukocytes (PMN) with ingested gonococci. The fate of N...
  10. ncbi Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    B Feinen
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    Mucosal Immunol 3:312-21. 2010
    Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and non-protective. We hypothesize that N...
  11. ncbi Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
    Wendy L Veal
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Bacteriol 184:5619-24. 2002
    ..efflux pump in conferring chromosomally mediated penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using genetic derivatives of penicillin-sensitive strain FA19 bearing defined mutations (..
  12. ncbi Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control
    Jessica G Cole
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:1629-41. 2010
    ..Opa(+) variants of Neisseria gonorrhoeae strain FA1090 are selected in a cyclical pattern from the lower genital tract of estradiol-treated mice...
  13. ncbi Type IV pilus structure and bacterial pathogenicity
    Lisa Craig
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Microbiol 2:363-78. 2004
  14. ncbi The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, 51 Newton Rd, BSB 3-403, Iowa City, IA 52242, USA
    Clin Microbiol Rev 17:965-81, table of contents. 2004
    ..A model of gonococcal pathogenesis is presented in the context of the male and female human urogenital tracts...
  15. ncbi Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 10:2257-70. 2008
    Symptomatic infection with Neisseria gonorrhoeae (Gc) results in a potent polymorphonuclear leukocyte (PMN)-driven inflammatory response, but the mechanisms by which Gc withstands PMN attack are poorly defined...
  16. ncbi The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways
    Shite Sebastian
    Evans Biomedical Research Center, Department of Medicine, Section of Infectious Diseases, Boston, Massachusetts 02118, USA
    J Bacteriol 184:3965-74. 2002
    In this study, we have characterized the in vitro binding of Neisseria gonorrhoeae Fur to several well-defined iron transport genes, as well as to additional genes involved in major catabolic, secretory, and recombination pathways of ..
  17. ncbi Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone
    Jennifer L Edwards
    The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children s Hospital and the Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Infect Immun 78:1202-13. 2010
    b>Neisseria gonorrhoeae is an obligate human pathogen that causes gonorrhea. We have shown previously that complement receptor 3 and Akt kinase play important roles in mediating cervical infection...
  18. ncbi Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection
    Harold C Wiesenfeld
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Clin Infect Dis 36:663-8. 2003
    ..with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3...
  19. ncbi Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide
    Megan L Falsetta
    Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
    Infect Immun 78:2320-8. 2010
    b>Neisseria gonorrhoeae is the etiologic agent of gonorrhea, which has been among the most frequently reported communicable diseases in the United States since 1960...
  20. ncbi Opposing selective forces for expression of the gonococcal lactoferrin receptor
    James E Anderson
    Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
    Mol Microbiol 48:1325-37. 2003
    All isolates of Neisseria gonorrhoeae express receptors that bind human transferrin (Tf). Although lactoferrin (Lf) is abundant on mucosa and in purulent exudates, many gonococci do not express an Lf receptor...
  21. ncbi Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000625. 2009
    ..b>Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin ..
  22. ncbi Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses
    Mathanraj Packiam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 78:433-40. 2010
    ..Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal ..
  23. ncbi Conjugative plasmids of Neisseria gonorrhoeae
    Emilia Pachulec
    Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    PLoS ONE 5:e9962. 2010
    Many clinical isolates of the human pathogen Neisseria gonorrhoeae contain conjugative plasmids...
  24. ncbi Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells
    Adam J Potter
    Australian Bacterial Pathogenesis Program and Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Australia
    J Infect Dis 199:227-35. 2009
    In Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress...
  25. ncbi Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon
    Lydgia A Jackson
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK 73104, USA
    J Bacteriol 192:77-85. 2010
    To ensure survival in the host, bacteria have evolved strategies to acquire the essential element iron. In Neisseria gonorrhoeae, the ferric uptake regulator Fur regulates metabolism through transcriptional control of iron-responsive ..
  26. ncbi The Neisseria gonorrhoeae biofilm matrix contains DNA, and an endogenous nuclease controls its incorporation
    Christopher T Steichen
    Department of Microbiolog, The University of Iowa, Iowa City, IA 52242, USA
    Infect Immun 79:1504-11. 2011
    b>Neisseria gonorrhoeae has been shown to produce biofilms both in experimental flow chambers and in the human host. Our laboratory has shown that extracellular DNA is an essential component of the gonococcal matrix...
  27. ncbi The transcriptome response of Neisseria gonorrhoeae to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection
    Elizabeth A Stohl
    Northwestern University, Feinberg School of Medicine, Department of Microbiology-Immunology, 303 E. Chicago Ave, Chicago, IL 60611, USA
    Mol Microbiol 58:520-32. 2005
    Symptomatic gonococcal infection, caused by the pathogen Neisseria gonorrhoeae (Gc), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection...
  28. ncbi Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum
    Lisa A Lewis
    Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA
    Infect Immun 77:1112-20. 2009
    The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N...
  29. ncbi Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden
    Daniel Golparian
    National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Sex Transm Infect 86:454-60. 2010
    b>Neisseria gonorrhoeae has developed resistance to most antimicrobials used for treatment...
  30. ncbi Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages
    Makoto Ohnishi
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Antimicrob Agents Chemother 54:1060-7. 2010
    In Neisseria gonorrhoeae, the mosaic type of penA, which encodes penicillin-binding protein 2 (PBP 2), is associated with reduced susceptibility to oral cephalosporins. To investigate the relatedness of N...
  31. ncbi Biofilm Formation by Neisseria gonorrhoeae
    L L Greiner
    Department of Microbiology, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Infect Immun 73:1964-70. 2005
    Studies were performed in continuous-flow chambers to determine whether Neisseria gonorrhoeae could form a biofilm. Under these growth conditions, N...
  32. ncbi DNA uptake sequence-mediated enhancement of transformation in Neisseria gonorrhoeae is strain dependent
    Paul M Duffin
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Bacteriol 192:4436-44. 2010
    Natural transformation is the main means of horizontal genetic exchange in the obligate human pathogen Neisseria gonorrhoeae. Neisseria spp...
  33. ncbi Untreated gonococcal and chlamydial infection in a probability sample of adults
    Charles F Turner
    Program in Health and Behavior Measurement, Research Triangle Institute, 1615 M St NW, Washington, DC 20036, USA
    JAMA 287:726-33. 2002
    ..Development of nucleic acid amplification tests, such as the ligase chain reaction assay, provides new opportunities to estimate the prevalence of untreated infections in the population...
  34. ncbi Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
    Milica Pantelic
    Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Indiana University School of Medicine, MS415E, 635 Barnhill Dr, Indianapolis, Indiana 46202-5120, USA
    Infect Immun 73:4171-9. 2005
    b>Neisseria gonorrhoeae cells (gonococci [GC]), the etiological agents for gonorrhea, can cause repeated infections. During and after gonococcal infection, local and systemic antigonococcal antibody levels are low...
  35. ncbi Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    Charlotte K Kent
    Department of Public Health, San Francisco, California, USA
    Clin Infect Dis 41:67-74. 2005
    ..However, in most clinical settings, rectal chlamydial testing is not performed for MSM, and primarily sexually transmitted disease (STD) clinics alone perform routine rectal and pharyngeal gonorrhea screening for asymptomatic men...
  36. ncbi Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment
    Kate L Seib
    The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Microbiol Mol Biol Rev 70:344-61. 2006
    b>Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract...
  37. ncbi Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms
    Stuart A Hill
    Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
    FEMS Microbiol Rev 33:521-30. 2009
    b>Neisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g...
  38. ncbi Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
    Kirsten Mattison
    Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:37942-51. 2006
    b>Neisseria gonorrhoeae is a sexually transmitted pathogen that initiates infections in humans by adhering to the mucosal epithelium of the urogenital tract...
  39. ncbi Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area
    Iona M C Martin
    Department of Infectious Diseases and Microbiology, Imperial College London, St Mary s Campus, London, United
    J Infect Dis 189:1497-505. 2004
    ....
  40. ncbi Genome sequencing reveals widespread virulence gene exchange among human Neisseria species
    Pradeep Reddy Marri
    The BIO5 Institute, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e11835. 2010
    ..Our findings strongly suggest that commensal Neisseria serve as reservoirs of virulence alleles, and that they engage extensively in genetic exchange...
  41. ncbi Local and humoral immune responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17beta-estradiol-treated mice
    Wenxia Song
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Vaccine 26:5741-51. 2008
    ..We conclude that similar to human infection, experimental murine infection induces local inflammation but not an acquired immune response or immunological memory...
  42. ncbi A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    Ann E Jerse
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 71:5576-82. 2003
    ..Two well-characterized multidrug resistance efflux systems (MtrCDE and FarAB-MtrE) exist in Neisseria gonorrhoeae, a bacterial pathogen of the human genital mucosae...
  43. ncbi Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae
    T C Fudyk
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bacteriol 181:5591-9. 1999
    The por genes of the predominant serovars of Neisseria gonorrhoeae circulating in a high-frequency transmitter core group located in Nairobi, Kenya, were examined for nucleotide sequence polymorphism...
  44. ncbi Clinical presentation of Mycoplasma genitalium Infection versus Neisseria gonorrhoeae infection among women with pelvic inflammatory disease
    Vanessa L Short
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 48:41-7. 2009
    ..The characteristics of nongonococcal, nonchlamydial PID have not been well described. Our objective was to examine the characteristics of Mycoplasma genitalium infection among women with clinically suspected PID...
  45. ncbi MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae
    Jason P Folster
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Bacteriol 191:287-97. 2009
    ..is known to repress transcription of the mtrCDE operon, which encodes a multidrug efflux pump possessed by Neisseria gonorrhoeae that is important in the ability of gonococci to resist certain hydrophobic antibiotics, detergents, dyes, ..
  46. ncbi Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells
    Karen H L Lim
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Australia
    Infect Immun 76:3569-76. 2008
    mntABC from Neisseria gonorrhoeae encodes an ABC permease which includes a periplasmic divalent cation binding receptor protein of the cluster IX family, encoded by mntC. Analysis of an mntC mutant showed that growth of N...
  47. ncbi Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli
    Ann E Jerse
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Infect Immun 70:2549-58. 2002
    b>Neisseria gonorrhoeae is capable of utilizing a variety of iron sources in vitro, including human transferrin, human lactoferrin, hemoglobin, hemoglobin-haptoglobin complexes, heme, and heterologous siderophores...
  48. ncbi Regulatory T cells are locally induced during intravaginal infection of mice with Neisseria gonorrhoeae
    Monica Imarai
    Laboratorio de Inmunologia, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Alameda 3363, Correo 40, Casilla 33, Santiago, Chile
    Infect Immun 76:5456-65. 2008
    b>Neisseria gonorrhoeae is a gram-negative diplococcus that in human beings produces gonorrhea...
  49. ncbi Meeting the public health challenge of multidrug- and extensively drug-resistant Neisseria gonorrhoeae
    John W Tapsall
    WHO Collaborating Centre for STD, Microbiology Department, The Prince of Wales Hospital, Randwick, Sydney, Australia
    Expert Rev Anti Infect Ther 7:821-34. 2009
    Globally, antimicrobial resistance (AMR) in Neisseria gonorrhoeae is increasing in prevalence, both within and across antibiotic classes, including extended-spectrum cephalosporins, raising concerns that gonorrhea may become untreatable ..
  50. ncbi Epithelial cell responses induced upon adherence of pathogenic Neisseria
    Laura Plant
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Nobels vag 16, SE 171 77 Stockholm, Sweden
    Cell Microbiol 6:663-70. 2004
    Neisseria meningitidis and Neisseria gonorrhoeae colonize human mucosal surfaces and cause sepsis/meningitis and gonorrhoea respectively...
  51. ncbi Azithromycin-resistant Neisseria gonorrhoeae strains recently isolated in Italy
    S Starnino
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Antimicrob Chemother 63:1200-4. 2009
    The aim of this study was to characterize 22 azithromycin-resistant Neisseria gonorrhoeae isolates, collected in Italy from January 2007 through June 2008, during a study of the prevalence of antibiotic resistance.
  52. ncbi Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers
    K A Schmidt
    Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC, USA
    Sex Transm Dis 28:555-64. 2001
    ..Reinfection, a common occurrence with gonorrhea, may result from a lack of protective immune response, or from the tremendous gonococcal strain variation...
  53. ncbi Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae
    Hsing Ju Wu
    Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan
    J Proteomics 73:899-916. 2010
    b>Neisseria gonorrhoeae has evolved a complex and novel network of oxidative stress responses, including defence mechanisms that are dependent on manganese (Mn)...
  54. ncbi Type IV secretion machinery promotes ton-independent intracellular survival of Neisseria gonorrhoeae within cervical epithelial cells
    Tracey A Zola
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 78:2429-37. 2010
    Survival of Neisseria gonorrhoeae within host epithelial cells is expected to be important in the pathogenesis of gonococcal disease...
  55. ncbi Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?
    Stephanie A Chisholm
    Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:2141-8. 2010
    ..Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and undertook pharmacodynamic analyses to predict efficacy against strains with raised MICs.
  56. ncbi Neisseria gonorrhoeae PLD directly interacts with Akt kinase upon infection of primary, human, cervical epithelial cells
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cell Microbiol 8:1253-71. 2006
    b>Neisseria gonorrhoeae secrets a phospholipase D (NgPLD), which augments complement receptor 3 (CR3)-mediated invasion of cervical epithelial cells...
  57. ncbi The fbpABC operon is required for Ton-independent utilization of xenosiderophores by Neisseria gonorrhoeae strain FA19
    Heather R Strange
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 79:267-78. 2011
    b>Neisseria gonorrhoeae produces no known siderophores but can employ host-derived, iron-binding proteins, including transferrin and lactoferrin, as iron sources...
  58. ncbi Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection
    Nathan J Weyand
    BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
    J Immunol 184:694-701. 2010
    ..Two human pathogens, Neisseria gonorrhoeae and Neisseria meningitidis, stimulate PS/gammaS processing of CD46-cyt1 and CD46-cyt2...
  59. ncbi Emergence of ciprofloxacin resistant Neisseria gonorrhoeae in north India
    Sunil Sethi
    Departments of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Res 123:707-10. 2006
    ..In this study we determined the antimicrobial susceptibility levels of consecutive isolates of Neisseria gonorrhoeae to examine the emergence of ciprofloxacin resistance N. gonorrhoeae.
  60. ncbi Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization
    Laura Serino
    Research Centre, Novartis Vaccines, Via Fiorentina, 1, 53100 Siena, Italy
    Mol Microbiol 64:1391-403. 2007
    ..Here we describe the identification of an OmpA-like protein in Neisseria gonorrhoeae (Ng-OmpA). We show that the gonococcal OmpA-like protein, similarly to E...
  61. ncbi Insertion-duplication mutagenesis of neisseria: use in characterization of DNA transfer genes in the gonococcal genetic island
    H L Hamilton
    Department of Medical Microbiology and Immunology, University of Wisconsin- Madison Medical School, Madison, Wisconsin 53706, USA
    J Bacteriol 183:4718-26. 2001
    We created plasmids for use in insertion-duplication mutagenesis (IDM) of Neisseria gonorrhoeae. This mutagenesis method has the advantage that it requires only a single cloning step prior to transformation into gonococci...
  62. ncbi CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells
    K V Swanson
    Centre for Immunochemistry, VA Medical Center, San Francisco, CA, USA
    Cell Microbiol 3:681-91. 2001
    b>Neisseria gonorrhoeae has a repertoire of up to 11 opacity-associated (Opa) proteins that are adhesins...
  63. ncbi Interval to treatment of sexually transmitted infections in adolescent females
    Amina I Malik
    University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Pediatr Adolesc Gynecol 20:275-9. 2007
    To describe (1) the treatment interval for adolescent females with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC), or Trichomonas vaginalis (TV); (2) the proportion treated in < or =7 days; and (3) factors influencing the ..
  64. ncbi NAAT-identified and self-reported gonorrhea and chlamydial infections: different at-risk population subgroups?
    Susan M Rogers
    Program in Health and Behavior Measurement, Research Triangle Institute, Washington, DC 20036, USA
    Sex Transm Dis 29:588-96. 2002
    ....
  65. ncbi Patient-delivered partner treatment and other partner management strategies for sexually transmitted diseases used by New York City healthcare providers
    Meighan E Rogers
    New York City Department of Health and Mental Hygiene, Bureau of Sexually Transmitted Disease Control, New York, New York 10013, USA
    Sex Transm Dis 34:88-92. 2007
    ....
  66. ncbi Trends in clinic visits and diagnosed Chlamydia trachomatis and Neisseria gonorrhoeae infections after the introduction of a copayment in a sexually transmitted infection clinic
    Cornelis A Rietmeijer
    Denver Public Health Department, Denver, Colorado 80204, USA
    Sex Transm Dis 32:243-6. 2005
    ..We evaluated the effects of the fee on clinic utilization and diagnosed Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infections.
  67. ncbi [Screening for Neisseria gonorrhoeae and Chlamydia trachomatis in human immunodeficiency virus positive men without urethritis symptoms]
    Istar Dolapci
    Ankara Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Ankara
    Mikrobiyol Bul 40:63-7. 2006
    ..The objective of the study was to determine the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in 18 HIV positive men without urethritis symptoms and in 70 HIV negative men with urethritis symptoms as ..
  68. ncbi Missed opportunities for early detection of chlamydia and gonorrhea in school-based health centers
    Malanda Nsuami
    School of Medicine, Department of Medicine, Section of Infectious Diseases, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Sex Transm Dis 33:703-5. 2006
    ..The purpose of the study was to assess the extent to which students are screened for sexually transmitted diseases (STDs) in their school-based health centers (SBHCs) in a Louisiana school district...
  69. ncbi Chlamydia trachomatis and Neisseria gonorrhoeae prevalence and coinfection in adolescents entering selected US juvenile detention centers, 1997-2002
    Richard H Kahn
    Division of STD Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Sex Transm Dis 32:255-9. 2005
    ..Juvenile detention centers offer public health practitioners an opportunity to gain access to large numbers of adolescents at risk for chlamydia and gonorrhea...
  70. ncbi Sex partner concurrency, geographic context, and adolescent sexually transmitted infections
    Jacky Jennings
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21224, USA
    Sex Transm Dis 31:734-9. 2004
    ..Sex partner concurrency has been shown to be associated with increased risk for individual-level STIs...
  71. ncbi Screening of males for Chlamydia trachomatis and Neisseria gonorrhoeae infections at STD clinics in three US cities -- Indianapolis, New Orleans, Seattle
    K S Kohl
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop E 61, Atlanta, GA, USA
    Int J STD AIDS 15:822-8. 2004
    We assessed prevalence and risk factor data for men routinely screened for Chlamydia trachomatis and Neisseria gonorrhoeae in STD clinics in four US cities from May 1995-March 1999...
  72. ncbi Correlates of sexually transmitted infections in young women
    H Hunter Handsfield
    J Infect Dis 195:303; author reply 303-5. 2007
  73. ncbi Unilateral twin ectopic pregnancy in a patient with a history of multiple sexually transmitted infections
    Charles J Rolle
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Infect Dis Obstet Gynecol 2006:10306. 2006
    ..with a history of four confirmed sexually transmitted infections (STIs) including Chlamydia trachomatis, Neisseria gonorrhoeae, herpes simplex virus 2, and Treponema pallidum...
  74. ncbi Sociodemographic markers and behavioral correlates of sexually transmitted infections in a nonclinical sample of adolescent and young adult women
    Cherrie B Boyer
    Department of Pediatrics, Division of Adolescent Medicine, University of California, San Francisco, San Francisco, CA 94143 0503, USA
    J Infect Dis 194:307-15. 2006
    ..We examined sociodemographic markers and 3-month behavioral correlates of sexually transmitted infections (STIs) in a nonclinical cross-section of adolescent and young adult women...
  75. ncbi Analysis of clinical manifestations of male patients with urethritis
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Infect Chemother 12:283-6. 2006
    ..Although the diagnosis of male urethritis can be performed by microbiological examination, the typical symptoms help us to distinguish each type of urethritis and understand this kind of disease...
  76. ncbi Higher vaginal pH is associated with Neisseria gonorrhoeae and Chlamydia trachomatis infection in a predominantly white population
    Satyajit Das
    Sex Transm Dis 33:527-8. 2006
  77. ncbi High prevalence of genital mycoplasmas among sexually active young adults with urethritis or cervicitis symptoms in La Crosse, Wisconsin
    Michael J Schlicht
    Microbiology Research Laboratory, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601, USA
    J Clin Microbiol 42:4636-40. 2004
    ..Urine specimens from both cohorts were tested by ligase chain reaction for Chlamydia trachomatis or Neisseria gonorrhoeae. In addition, the urethral or cervical swabs from the symptomatic subjects were tested by PCR for ..
  78. ncbi APTIMA transcription-mediated amplification assays for Chlamydia trachomatis and Neisseria gonorrhoeae
    Max A Chernesky
    McMaster University, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada
    Expert Rev Mol Diagn 6:519-25. 2006
    The APTIMA transcription-mediated amplification assays for Chlamydia trachomatis and Neisseria gonorrhoeae have the greatest sensitivity of all the commercial nucleic acid amplification tests for the diagnosis of infections from ..
  79. ncbi Trends of sexually transmitted diseases and antimicrobial resistance in Neisseria gonorrhoeae
    T Matsumoto
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Japan
    Int J Antimicrob Agents 31:S35-9. 2008
    ..gonorrhoeae from the urethra, cervix and pharynx obtained in a recent study...
  80. ncbi Evaluation of a testing-only "express" visit option to enhance efficiency in a busy STI clinic
    Sara J Shamos
    Denver Public Health Department, Denver, Colorado 80204 4506, USA
    Sex Transm Dis 35:336-40. 2008
    ..To evaluate the use of a testing-only "express" visit option to enhance efficiency in a busy STI clinic...
  81. ncbi Quantifying leukocytes in first catch urine provides new insights into our understanding of symptomatic and asymptomatic urethritis
    Rebecca C Wiggins
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol BS2 8AE, UK
    Int J STD AIDS 17:289-95. 2006
    ..001), and detection of Chlamydia trachomatis (P < 0.001) and Neisseria gonorrhoeae (P < 0.001)...
  82. ncbi Accounting for failures may improve precision: evidence supporting improved validity of self-reported condom use
    Richard Crosby
    College of Public Health, University of Kentucky, Lexington, Kentucky 40506 0003, USA
    Sex Transm Dis 32:513-5. 2005
    ..To determine whether a measure of unprotected vaginal sex that is adjusted for condom failures would produce improved accuracy in predicting biologically confirmed STDs (chlamydia and gonorrhea) among female teens...
  83. ncbi Condom use and risk of gonorrhea and Chlamydia: a systematic review of design and measurement factors assessed in epidemiologic studies
    Lee Warner
    National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Sex Transm Dis 33:36-51. 2006
    ..Epidemiologic studies that better address these factors are needed to provide more accurate assessment of condom effectiveness...
  84. ncbi Simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis by PCR in genitourinary specimens from men and women attending an STD clinic
    Preena Bhalla
    Department of Microbiology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi
    J Commun Dis 39:1-6. 2007
    b>Neisseria gonorrhoeae and Chlamydia trachomatis are the two most common bacterial sexually transmitted infections that manifest primarily as urethritis in males and endocervicitis in females, though the infection may be asymptomatic ..
  85. ncbi Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: implications for diagnostic approach and management
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Sex Transm Dis 32:630-4. 2005
    ..In the absence of signs, symptoms, or polymorphonuclear leukocytes (PMNs) on urethral Gram stain, treatment and sometimes testing is deferred...
  86. ncbi DNA sequencing validation of Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid tests
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, CT
    Am J Clin Pathol 129:852-9. 2008
    DNA sequencing was used to confirm Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acids in endocervical swab samples...
  87. ncbi Prevalence of sexually transmitted infections among sexually active Jordanian females
    Azmi M Mahafzah
    Department of Pathology, University of Jordan, Amman, Jordan
    Sex Transm Dis 35:607-10. 2008
    ..To determine the prevalence of the most important sexually transmitted infections among women of child bearing age in Jordan...
  88. ncbi Diagnostic tests for chlamydial and gonorrheal infections
    Elyse Olshen
    Division of Adolescent Young Adult Medicine, Children s Hosital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Pediatr Infect Dis 16:192-8. 2005
    Chlamydia trachomatis and Neisseria gonorrhoeae are the two most prevalent bacterial sexually transmitted infections reported in the United States. The purpose of this article is to review the various tests available for diagnosing C...
  89. ncbi Child sexual abuse examination: is there a need for routine screening for N gonorrhoeae and C trachomatis?
    Karen J Simmons
    Rape Treatment Center, Jackson Memorial Hospital, and the Department of Obstetrics and Gynecology, University of Miami, Miami, Florida 33136, USA
    J Pediatr Adolesc Gynecol 18:343-5. 2005
    To determine the yield of routine vaginal cultures for Neisseria gonorrhoeae and Chlamydia trachomatis from girls evaluated following sexual abuse.
  90. ncbi Comparison of three in-house multiplex PCR assays for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis using real-time and conventional detection methodologies
    David M Whiley
    Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital and Health Service District, Brisbane, Queensland, Australia
    Pathology 37:364-70. 2005
    To develop and evaluate multiplex PCR assays for Chlamydia trachomatis and Neisseria gonorrhoeae, using real-time and conventional PCR detection methodologies.
  91. ncbi Performance of strand displacement amplification assay in the detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    Carla Fontana
    Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University of Rome, Italy
    Jpn J Infect Dis 58:283-8. 2005
    This study is a critical analysis of certain amplification assays for detecting Chlamydia trachomatis and Neisseria gonorrhoeae infections which have demonstrated that the plasmid-free variant of C...
  92. ncbi Diagnosis of sexually transmitted infections (STI) using self-collected non-invasive specimens
    Suzanne M Garland
    Department of Microbiology and Infectious Diseases, The Royal Women s Hospital of Women s and Children s Health, 132 Grattan Street, Carlton, VIC 3053, Australia
    Sex Health 1:121-6. 2004
    ....
  93. ncbi Single-dose treatment of male patients with gonococcal urethritis using 2g spectinomycin: microbiological and clinical evaluations
    Munekado Kojima
    Department of Urology, Nagoya Urology Hospital, 5 34 Matsuba, Nagoya, Japan
    Int J Antimicrob Agents 32:50-4. 2008
    ..5%) could be evaluated, in 28 (13.3%) of whom Chlamydia trachomatis was detected in addition to Neisseria gonorrhoeae. A single dose of spectinomycin eradicated N. gonorrhoeae in 203 (96.7%) of the 210 patients...
  94. ncbi The prevalence of chlamydia, gonorrhea, and trichomonas in sexual partnerships: implications for partner notification and treatment
    Ayesha Khan
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Sex Transm Dis 32:260-4. 2005
    ..However, limited data exists regarding STIs within sexual partnerships (dyads)...
  95. ncbi Utility of pooled urine specimens for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in men attending public sexually transmitted infection clinics in Mumbai, India, by PCR
    Christina Lindan
    Institute for Global Health, Department of Epidemiology, Center for AIDS Prevention Studies, San Francisco, CA 94110, USA
    J Clin Microbiol 43:1674-7. 2005
    Pooling urogenital specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae by nucleic acid amplification tests is an attractive alternative to individual testing...
  96. ncbi Nucleic acid amplification tests (polymerase chain reaction, ligase chain reaction) for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in pediatric emergency medicine
    Howard M Corneli
    Department of Pediatrics, University of Utah, School of Medicine, Salt Lake City UT 84102, USA
    Pediatr Emerg Care 21:264-70; quiz 271-3. 2005
    ..advantages of speed, simplicity, and accuracy in the detection of genitourinary tract infection with Neisseria gonorrhoeae and Chlamydia trachomatis...
  97. ncbi Should we still be testing for asymptomatic non-specific urethritis in departments of genitourinary medicine?
    P J Horner
    Milne Sexual Health Centre, Bristol Royal Infirmary, Lower Maudlin Street, Bristol BS2 8HW, UK
    Int J STD AIDS 16:273-7. 2005
    ..urine specimens using nucleic acid amplification techniques, to detect Chlamydia trachomatis and Neisseria gonorrhoeae, should replace routine microscopy on asymptomatic men...
  98. ncbi School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students
    Lenore E Asbel
    Philadelphia Department of Public Health, Drexel University College of Medicine, Pennsylvania, USA
    Sex Transm Dis 33:614-20. 2006
    ..The prevalence of sexually transmitted diseases among adolescents is high. Innovative screening and treatment programs need evaluation...
  99. ncbi Male accessory gland infection
    W Krause
    Department of Dermatology and Allergology, University Hospital, Philipp University, Marburg, Germany
    Andrologia 40:113-6. 2008
    ..Haematogenous infections are rare. The main infectious agents are Neisseria gonorrhoeae and Chlamydia trachomatis, and also enterobacteriae at a lesser frequency...
  100. ncbi Sexual risk behaviors and sexually transmitted infection prevalence in an outpatient psychiatry clinic
    Cynthia King
    Department of Medicine, The University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:877-82. 2008
    ..Few data describe the prevalence of risk behaviors or STI among persons with SPMI. We aim to quantitate STI/human immunodeficiency virus risk and determine the STI prevalence amongst outpatient psychiatric clinic attendees...
  101. ncbi Acceptability of self-taken vaginal swabs and first-catch urine samples for the diagnosis of urogenital Chlamydia trachomatis and Neisseria gonorrhoeae with an amplified DNA assay in young women attending a public health sexually transmitted disease clini
    Christian J P A Hoebe
    Department of Infectious Diseases, South Limburg Public Health Service, Heerlen, The Netherlands
    Sex Transm Dis 33:491-5. 2006
    Public health efforts are needed to encourage young women to get tested for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC).

Research Grants87

  1. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 2001
    ..In addition, these findings will contribute to the development of effective diagnosis and therapies of human trichomoniasis. ..
  2. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2010
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the ..
  3. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2009
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the ..
  4. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
    ..idiopathic, not attributable to the major sexually transmitted pathogens such as Chlamydia trachomatis or Neisseria gonorrhoeae. Where effective STD control programs exist, most urethritis in men and endocervicitis or mucopurulent ..
  5. PENICILLIN RESISTANT NEISSERIA GONORRHOEAE (CMRNG)
    Robert Nicholas; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Neisseria gonorrhoeae is the causative agent of gonorrhea, an STD that continues to be a public health problem...
  6. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1993
    ....
  7. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..HSV-2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi and Chlamydia trachomatis; b) inactivated bacteria associated ..
  8. Type IV secretion by Neisseria gonorrhoeae
    JOSEPH DILLARD; Fiscal Year: 2005
    b>Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhea, the more serious infections pelvic inflammatory disease (PID) and disseminated gonococcal infection (DGI). We identified a 57 kb genetic island present in N...
  9. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2010
    b>Neisseria gonorrhoeae (Gc) induces an intense inflammatory response that is characterized by the presence of numerous polymorphonuclear leukocytes (PMNs) with intracellular Gc...
  10. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the application abstract) Neisseria gonorrhoeae is one of the two major pathogens involved in the majority of cases of bacterial sexually transmitted genital infection and pelvic inflammatory disease (PID)...
  11. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..of how lipooligosaccharide (LOS) mimicry of human glycosphingolipids (GSL) enables the transmission of Neisseria gonorrhoeae in order to find ways to prevent it...
  12. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2003
    DESCRIPTION (Adapted from the applicant's abstract): Neisseria gonorrhoeae has a serious impact on women=s health due to the frequency with which this pathogen infects the upper reproductive tract, and the resultant serious complications ..
  13. Penicillin-resistant Neisseria gonorrhoeae (CMRNG)
    Robert Nicholas; Fiscal Year: 2005
    Antibiotic resistance in Neisseria gonorrhoeae remains a very important problem...
  14. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    The human pathogen Neisseria gonorrhoeae produces an array of diseases ranging from urethritis and cervicitis to pelvic inflammatory disease. Early events in the establishment of infection involve interactions between N...
  15. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2006
    ..Along with other pathogenic bacteria, antibiotic resistance in Neisseria gonorrhoeae is a growing problem...
  16. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..age group at highest risk for STIs, the CDC recommends annual screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in all sexually active (SA) adolescents, regardless of symptoms...