neisseria gonorrhoeae

Summary

Summary: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.

Top Publications

  1. pmc Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
    Makoto Ohnishi
    National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:3538-45. 2011
  2. pmc Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 11:1074-87. 2009
  3. pmc An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae
    Laty A Cahoon
    Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Science 325:764-7. 2009
  4. pmc Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
  5. doi Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells
    Michael P Jennings
    Institute for Glycomics, Griffith University, Gold Coast Campus, Australia
    Cell Microbiol 13:885-96. 2011
  6. ncbi Type IV pilus structure and bacterial pathogenicity
    Lisa Craig
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Microbiol 2:363-78. 2004
  7. pmc Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
    Hong Wu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:4094-103. 2006
  8. ncbi Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
    H J Tseng
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Microbiol 40:1175-86. 2001
  9. pmc Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    W M Shafer
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 95:1829-33. 1998
  10. ncbi Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
    Max A Chernesky
    St Joseph s Healthcare, Hamilton, Ontario, Canada
    Sex Transm Dis 32:729-33. 2005

Detail Information

Publications314 found, 100 shown here

  1. pmc Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
    Makoto Ohnishi
    National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:3538-45. 2011
    Recently, the first Neisseria gonorrhoeae strain (H041) that is highly resistant to the extended-spectrum cephalosporin (ESC) ceftriaxone, the last remaining option for empirical first-line treatment, was isolated...
  2. pmc Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 11:1074-87. 2009
    Symptomatic infection with Neisseria gonorrhoeae (Gc) is characterized by abundant neutrophil (PMN, polymorphonuclear leucocyte) influx, but PMNs cannot clear initial infection, indicating that Gc possess defences against PMN challenge...
  3. pmc An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae
    Laty A Cahoon
    Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Science 325:764-7. 2009
    ..We identified a cis-acting DNA sequence near the antigenically variable pilin locus of the human pathogen, Neisseria gonorrhoeae. This 16-base pair guanine (G)-rich sequence was required for pilin Av and formed a guanine quartet (G4) ..
  4. pmc Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
    ..These studies establish a hierarchy of mtrR locus mutations with regard to regulation of pump efflux, and suggest selection for more derepressed mutants may occur during mixed infections...
  5. doi Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells
    Michael P Jennings
    Institute for Glycomics, Griffith University, Gold Coast Campus, Australia
    Cell Microbiol 13:885-96. 2011
    Expression of type IV pili by Neisseria gonorrhoeae plays a critical role in mediating adherence to human epithelial cells...
  6. ncbi Type IV pilus structure and bacterial pathogenicity
    Lisa Craig
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Microbiol 2:363-78. 2004
  7. pmc Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
    Hong Wu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:4094-103. 2006
    The addition of host-derived sialic acid to Neisseria gonorrhoeae lipooligosaccharide is hypothesized to be an important mechanism by which gonococci evade host innate defenses...
  8. ncbi Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
    H J Tseng
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Microbiol 40:1175-86. 2001
    As a facultative aerobe with a high iron requirement and a highly active aerobic respiratory chain, Neisseria gonorrhoeae requires defence systems to respond to toxic oxygen species such as superoxide...
  9. pmc Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    W M Shafer
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 95:1829-33. 1998
    ..capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-..
  10. ncbi Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
    Max A Chernesky
    St Joseph s Healthcare, Hamilton, Ontario, Canada
    Sex Transm Dis 32:729-33. 2005
    Self-collected specimens can be used to screen asymptomatic women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC)...
  11. pmc Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis infection: results from a randomized, controlled trial in Kenya
    Supriya D Mehta
    Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois, USA
    J Infect Dis 200:370-8. 2009
    ..We examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (STIs)...
  12. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..CT/NG assay, a multiplex real-time PCR assay, for simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae. The specimens were collected from a total of 3,832 male and female subjects at 16 geographically diverse ..
  13. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
    Recently, the first Neisseria gonorrhoeae strain (H041) highly resistant to the expanded-spectrum cephalosporins (ESCs) ceftriaxone and cefixime, which are the last remaining options for first-line gonorrhea treatment, was isolated in ..
  14. pmc A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation
    I J Mehr
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Genetics 154:523-32. 2000
    b>Neisseria gonorrhoeae pilin undergoes high-frequency changes in primary amino acid sequence that aid in the avoidance of the host immune response and alter pilus expression...
  15. ncbi Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions
    Lisa Craig
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Mol Cell 23:651-62. 2006
    ..b>Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-..
  16. doi UK national guideline for the management of gonorrhoea in adults, 2011
    C Bignell
    Nottingham University Hospitals NHS Trust, Nottingham, UK
    Int J STD AIDS 22:541-7. 2011
    ..The aim is to slow the spread of resistant gonorrhoea now that fewer antibiotics remain effective. A patient information leaflet has been developed...
  17. pmc Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    B Feinen
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    Mucosal Immunol 3:312-21. 2010
    Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and non-protective. We hypothesize that N...
  18. ncbi A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cell Microbiol 4:571-84. 2002
    ..In conjunction, these molecules facilitate targeting to and successful infection of the cervical epithelium...
  19. pmc Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
    Wendy L Veal
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Bacteriol 184:5619-24. 2002
    ..efflux pump in conferring chromosomally mediated penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using genetic derivatives of penicillin-sensitive strain FA19 bearing defined mutations (..
  20. pmc Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
    S Ram
    Evans Biomedical Research Center, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Exp Med 193:281-95. 2001
    We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp)...
  21. pmc Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control
    Jessica G Cole
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:1629-41. 2010
    ..Opa(+) variants of Neisseria gonorrhoeae strain FA1090 are selected in a cyclical pattern from the lower genital tract of estradiol-treated mice...
  22. pmc Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes
    Mark P Simons
    Department of Microbiology, 3 403 Bowen Science Building, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Infect Immun 73:1971-7. 2005
    b>Neisseria gonorrhoeae causes severe exudative urethritis. The exudates from infected individuals contain large numbers of polymorphonuclear leukocytes (PMN) with ingested gonococci. The fate of N...
  23. pmc Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay
    Kate L Seib
    The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Infect Immun 73:5269-72. 2005
    b>Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N...
  24. ncbi A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates
    J P Dillard
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Microbiol 41:263-77. 2001
    b>Neisseria gonorrhoeae (the gonococcus) is the causative agent of the sexually transmitted disease gonorrhoea...
  25. ncbi Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
    J Pohlner
    Nature 325:458-62. 1987
    Several human bacterial pathogens, including the Gram-negative diplococcus Neisseria gonorrhoeae, produce extracellular proteases that are specific for human immunoglobulin IgA1...
  26. pmc The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women
    Jennifer L Edwards
    Department of Microbiology, The University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
    Clin Microbiol Rev 17:965-81, table of contents. 2004
    ..A model of gonococcal pathogenesis is presented in the context of the male and female human urogenital tracts...
  27. pmc Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Microbiol 10:2257-70. 2008
    Symptomatic infection with Neisseria gonorrhoeae (Gc) results in a potent polymorphonuclear leukocyte (PMN)-driven inflammatory response, but the mechanisms by which Gc withstands PMN attack are poorly defined...
  28. pmc Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria
    Laty A Cahoon
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Microbiol 81:1136-43. 2011
    ..without deleterious effects on the genome in the well-characterized pilin antigenic variation systems of Neisseria gonorrhoeae and Neisseria meningitidis is presented...
  29. pmc Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens
    Tim Schmitter
    Zentrum für Infektionsforschung, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Exp Med 199:35-46. 2004
    ....
  30. pmc Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
    E Van Dyck
    STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Clin Microbiol 39:1751-6. 2001
    ..and compare three commercially available nucleic acid amplification tests (NAATs) for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis...
  31. pmc Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
    Joseph A Duncan
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 182:6460-9. 2009
    b>Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts female fertility, neonatal health, and transmission of HIV worldwide. N...
  32. pmc The incidence and correlates of symptomatic and asymptomatic Chlamydia trachomatis and Neisseria gonorrhoeae infections in selected populations in five countries
    Roger Detels
    Department of Epidemiology, UCLA School of Public Health, 71 269 CHS, Box 951772, Los Angeles, CA 90095 1772, USA
    Sex Transm Dis 38:503-9. 2011
    Asymptomatic Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) infections pose diagnostic and control problems in developing countries.
  33. pmc Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction
    Constance M John
    Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Lipid Res 50:424-38. 2009
    ..This methodology enabled us to rapidly profile components of structural variants of native LOS that are of importance biologically...
  34. pmc Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus
    Juliana Li
    Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    J Mol Biol 418:47-64. 2012
    ..folds, we compared the stabilities of pilin subunits and pilus filaments for the Type IVa GC pilus from Neisseria gonorrhoeae and the Type IVb toxin-coregulated pilus (TCP) from Vibrio cholerae...
  35. pmc Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae
    Vincent M Isabella
    Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    BMC Genomics 12:51. 2011
    Maintenance of an anaerobic denitrification system in the obligate human pathogen, Neisseria gonorrhoeae, suggests that an anaerobic lifestyle may be important during the course of infection...
  36. pmc Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009
    Supriya D Mehta
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60622, USA
    Antimicrob Agents Chemother 55:3882-8. 2011
    We evaluated antimicrobial resistance in Neisseria gonorrhoeae isolated from men enrolled in a randomized trial of male circumcision to prevent HIV. Urethral specimens from men with discharge were cultured for N. gonorrhoeae...
  37. pmc The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth
    Michelle A Graver
    Medical Microbiology, King s College Hospital, Denmark Hill, London, UK
    Ann Clin Microbiol Antimicrob 10:8. 2011
    ..vaginosis, normal lactobacilli are replaced by an anaerobic flora and this may increase susceptibility to Neisseria gonorrhoeae, a facultative anaerobe. Bacterial interference between vaginal lactobacilli and N...
  38. pmc Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000625. 2009
    ..b>Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin ..
  39. pmc DNA uptake sequence-mediated enhancement of transformation in Neisseria gonorrhoeae is strain dependent
    Paul M Duffin
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Bacteriol 192:4436-44. 2010
    Natural transformation is the main means of horizontal genetic exchange in the obligate human pathogen Neisseria gonorrhoeae. Neisseria spp...
  40. pmc Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone
    Jennifer L Edwards
    The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children s Hospital and the Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Infect Immun 78:1202-13. 2010
    b>Neisseria gonorrhoeae is an obligate human pathogen that causes gonorrhea. We have shown previously that complement receptor 3 and Akt kinase play important roles in mediating cervical infection...
  41. pmc Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages
    Makoto Ohnishi
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Antimicrob Agents Chemother 54:1060-7. 2010
    In Neisseria gonorrhoeae, the mosaic type of penA, which encodes penicillin-binding protein 2 (PBP 2), is associated with reduced susceptibility to oral cephalosporins. To investigate the relatedness of N...
  42. pmc The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways
    Shite Sebastian
    Evans Biomedical Research Center, Department of Medicine, Section of Infectious Diseases, Boston, Massachusetts 02118, USA
    J Bacteriol 184:3965-74. 2002
    In this study, we have characterized the in vitro binding of Neisseria gonorrhoeae Fur to several well-defined iron transport genes, as well as to additional genes involved in major catabolic, secretory, and recombination pathways of ..
  43. pmc The transcriptome response of Neisseria gonorrhoeae to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection
    Elizabeth A Stohl
    Northwestern University, Feinberg School of Medicine, Department of Microbiology Immunology, 303 E Chicago Ave, Chicago, IL 60611, USA
    Mol Microbiol 58:520-32. 2005
    Symptomatic gonococcal infection, caused by the pathogen Neisseria gonorrhoeae (Gc), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection...
  44. ncbi Untreated gonococcal and chlamydial infection in a probability sample of adults
    Charles F Turner
    Program in Health and Behavior Measurement, Research Triangle Institute, 1615 M St NW, Washington, DC 20036, USA
    JAMA 287:726-33. 2002
    ..Development of nucleic acid amplification tests, such as the ligase chain reaction assay, provides new opportunities to estimate the prevalence of untreated infections in the population...
  45. pmc Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon
    Lydgia A Jackson
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK 73104, USA
    J Bacteriol 192:77-85. 2010
    To ensure survival in the host, bacteria have evolved strategies to acquire the essential element iron. In Neisseria gonorrhoeae, the ferric uptake regulator Fur regulates metabolism through transcriptional control of iron-responsive ..
  46. pmc Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells
    Adam J Potter
    Australian Bacterial Pathogenesis Program and Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Australia
    J Infect Dis 199:227-35. 2009
    In Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress...
  47. pmc Biofilm Formation by Neisseria gonorrhoeae
    L L Greiner
    Department of Microbiology, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Infect Immun 73:1964-70. 2005
    Studies were performed in continuous-flow chambers to determine whether Neisseria gonorrhoeae could form a biofilm. Under these growth conditions, N...
  48. ncbi Opposing selective forces for expression of the gonococcal lactoferrin receptor
    James E Anderson
    Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
    Mol Microbiol 48:1325-37. 2003
    All isolates of Neisseria gonorrhoeae express receptors that bind human transferrin (Tf). Although lactoferrin (Lf) is abundant on mucosa and in purulent exudates, many gonococci do not express an Lf receptor...
  49. pmc Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum
    Lisa A Lewis
    Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA
    Infect Immun 77:1112-20. 2009
    The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N...
  50. pmc The Neisseria gonorrhoeae biofilm matrix contains DNA, and an endogenous nuclease controls its incorporation
    Christopher T Steichen
    Department of Microbiolog, The University of Iowa, Iowa City, IA 52242, USA
    Infect Immun 79:1504-11. 2011
    b>Neisseria gonorrhoeae has been shown to produce biofilms both in experimental flow chambers and in the human host. Our laboratory has shown that extracellular DNA is an essential component of the gonococcal matrix...
  51. pmc Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide
    Megan L Falsetta
    Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
    Infect Immun 78:2320-8. 2010
    b>Neisseria gonorrhoeae is the etiologic agent of gonorrhea, which has been among the most frequently reported communicable diseases in the United States since 1960...
  52. ncbi Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection
    Harold C Wiesenfeld
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Clin Infect Dis 36:663-8. 2003
    ..with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3...
  53. pmc Conjugative plasmids of Neisseria gonorrhoeae
    Emilia Pachulec
    Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    PLoS ONE 5:e9962. 2010
    Many clinical isolates of the human pathogen Neisseria gonorrhoeae contain conjugative plasmids...
  54. doi Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden
    Daniel Golparian
    National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Sex Transm Infect 86:454-60. 2010
    b>Neisseria gonorrhoeae has developed resistance to most antimicrobials used for treatment...
  55. pmc Comparing first-void urine specimens, self-collected vaginal swabs, and endocervical specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae by a nucleic acid amplification test
    Mary Ann Shafer
    Division of Adolescent Medicine, Department of Pediatrics, University of California, San Francisco 94143, USA
    J Clin Microbiol 41:4395-9. 2003
    We set out to determine the prevalences of Chlamydia trachomatis and Neisseria gonorrhoeae by ligase chain reaction as well as to determine the prevalence of Trichomonas vaginalis by culture in a large and diverse national sample of non-..
  56. pmc Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses
    Mathanraj Packiam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 78:433-40. 2010
    ..Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal ..
  57. pmc Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells
    Abdel Rahman Youssef
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Infect Immun 77:5170-80. 2009
    ..The data also imply that Opa-proficient vaccine preparations may not necessarily inhibit T-cell functions via CEACAM1 binding...
  58. pmc The phosphorylcholine epitope undergoes phase variation on a 43-kilodalton protein in Pseudomonas aeruginosa and on pili of Neisseria meningitidis and Neisseria gonorrhoeae
    J N Weiser
    Departments of Pediatrics and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Immun 66:4263-7. 1998
    ..Expression of the ChoP epitope on piliated neisseriae displayed phase variation, both linked to pilus expression and independently of fully piliated bacteria...
  59. pmc Broad spectrum O-linked protein glycosylation in the human pathogen Neisseria gonorrhoeae
    Ashild Vik
    Department of Molecular Biosciences and Center for Molecular Biology and Neuroscience, University of Oslo, Oslo 0316, Norway
    Proc Natl Acad Sci U S A 106:4447-52. 2009
    ..and functionally diverse groups of membrane-associated proteins in the gram-negative bacterium Neisseria gonorrhoeae, the etiologic agent of the human disease gonorrhea...
  60. ncbi Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area
    Iona M C Martin
    Department of Infectious Diseases and Microbiology, Imperial College London, St Mary s Campus, London, United
    J Infect Dis 189:1497-505. 2004
    ....
  61. pmc Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
    Milica Pantelic
    Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Indiana University School of Medicine, MS415E, 635 Barnhill Dr, Indianapolis, Indiana 46202 5120, USA
    Infect Immun 73:4171-9. 2005
    b>Neisseria gonorrhoeae cells (gonococci [GC]), the etiological agents for gonorrhea, can cause repeated infections. During and after gonococcal infection, local and systemic antigonococcal antibody levels are low...
  62. pmc Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms
    Stuart A Hill
    Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
    FEMS Microbiol Rev 33:521-30. 2009
    b>Neisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g...
  63. ncbi Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    Charlotte K Kent
    Department of Public Health, San Francisco, California, USA
    Clin Infect Dis 41:67-74. 2005
    ..However, in most clinical settings, rectal chlamydial testing is not performed for MSM, and primarily sexually transmitted disease (STD) clinics alone perform routine rectal and pharyngeal gonorrhea screening for asymptomatic men...
  64. pmc Genome sequencing reveals widespread virulence gene exchange among human Neisseria species
    Pradeep Reddy Marri
    The BIO5 Institute, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e11835. 2010
    ..Our findings strongly suggest that commensal Neisseria serve as reservoirs of virulence alleles, and that they engage extensively in genetic exchange...
  65. pmc Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment
    Kate L Seib
    The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Microbiol Mol Biol Rev 70:344-61. 2006
    b>Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract...
  66. ncbi Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
    Kirsten Mattison
    Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:37942-51. 2006
    b>Neisseria gonorrhoeae is a sexually transmitted pathogen that initiates infections in humans by adhering to the mucosal epithelium of the urogenital tract...
  67. pmc The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species
    Eric P Skaar
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Searle 6 497, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:10108-13. 2002
    The PilB protein of Neisseria gonorrhoeae has been reported to be involved in the regulation of pilin gene transcription, but it also possesses significant homology to the peptide methionine sulfoxide reductase family of enzymes, ..
  68. pmc Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways
    Oliver Billker
    Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Schumannstrasse 21 22, D 10117 Berlin, Germany
    EMBO J 21:560-71. 2002
    ..CEACAM receptors mediate opsonization-independent phagocytosis of Neisseria gonorrhoeae by human granulocytes and each receptor individually can mediate gonococcal invasion of epithelial cells...
  69. ncbi Characterization of the OxyR regulon of Neisseria gonorrhoeae
    Kate L Seib
    School of Molecular and Microbial Sciences and Centre for Metals in Biology, The University of Queensland, Brisbane 4072, QLD, Australia
    Mol Microbiol 63:54-68. 2007
    ..a previous study we reported the OxyR-dependent derepression of catalase expression in the human pathogen Neisseria gonorrhoeae. In the present study we used microarray expression profiling of N...
  70. ncbi Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..endocervical epithelial cells were unresponsive to protein-free preparations of lipooligosaccharide from Neisseria gonorrhoeae and LPS from Escherichia coli...
  71. pmc A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    Ann E Jerse
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 71:5576-82. 2003
    ..Two well-characterized multidrug resistance efflux systems (MtrCDE and FarAB-MtrE) exist in Neisseria gonorrhoeae, a bacterial pathogen of the human genital mucosae...
  72. pmc Local and humoral immune responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17beta-estradiol-treated mice
    Wenxia Song
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Vaccine 26:5741-51. 2008
    ..We conclude that similar to human infection, experimental murine infection induces local inflammation but not an acquired immune response or immunological memory...
  73. pmc Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae
    T C Fudyk
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bacteriol 181:5591-9. 1999
    The por genes of the predominant serovars of Neisseria gonorrhoeae circulating in a high-frequency transmitter core group located in Nairobi, Kenya, were examined for nucleotide sequence polymorphism...
  74. pmc Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers
    Tim W Overton
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Bacteriol 190:2004-13. 2008
    Expression of two genes of unknown function, Staphylococcus aureus scdA and Neisseria gonorrhoeae dnrN, is induced by exposure to oxidative or nitrosative stress...
  75. pmc Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 286:9555-66. 2011
    ..CEACAM3 functions as a single chain phagocytotic receptor recognizing gram-negative bacteria such as Neisseria gonorrhoeae, which possess CEACAM-binding adhesins on their surface...
  76. pmc O-acetylation of peptidoglycan in gram-negative bacteria: identification and characterization of peptidoglycan O-acetyltransferase in Neisseria gonorrhoeae
    Patrick J Moynihan
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 285:13264-73. 2010
    The ape2 gene encoding a hypothetical O-acetylpeptidoglycan esterase was amplified from genomic DNA of Neisseria gonorrhoeae FA1090 and cloned to encode either the full-length protein or a truncated version lacking its hypothetical ..
  77. ncbi In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
    Debmalya Barh
    Institute of Integrative Omics and Applied Biotechnology IIOAB, Nonakuri, India
    In Silico Biol 9:225-31. 2009
    b>Neisseria gonorrhoeae is responsible for causing gonorrhea, one of the most common sexually transmitted diseases prevailing globally...
  78. pmc Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations
    Joshua Tomberg
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    Biochemistry 49:8062-70. 2010
    ..crucial for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae. Three of the ∼60 mutations present in mosaic alleles of penA, G545S, I312M, and V316T, have been ..
  79. pmc Mismatch correction modulates mutation frequency and pilus phase and antigenic variation in Neisseria gonorrhoeae
    Alison K Criss
    Department of Microbiology Immunology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Bacteriol 192:316-25. 2010
    ..To test the functions of MMC in the obligate human pathogen Neisseria gonorrhoeae, homologues of the core MMC genes mutS and mutL were inactivated in strain FA1090...
  80. ncbi Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, UK
    Mol Microbiol 35:32-43. 2000
    Infection of the endometrium by Neisseria gonorrhoeae is a pivotal stage in the development of pelvic inflammatory disease in women...
  81. pmc Home versus clinic-based specimen collection for Chlamydia trachomatis and Neisseria gonorrhoeae
    Anna S Graseck
    Washington University in St Louis School of Medicine, Division of Clinical Research, Department of Obstetrics and Gynecology, Campus Box 8219, 4533 Clayton Avenue, St Louis, MO 63110, USA
    Expert Rev Anti Infect Ther 9:183-94. 2011
    ..This article describes and evaluates the effectiveness and limitations of various home screening strategies used for the detection of STIs...
  82. ncbi Neisseria gonorrhoeae type IV pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally related to lipopolysaccharide phosphoethanolamine transferases
    Finn Erik Aas
    Centre for Molecular Biology and Neuroscience, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway
    J Biol Chem 281:27712-23. 2006
    ..PilE, the major pilin subunit protein of the type IV pilus (Tfp) colonization factor of Neisseria gonorrhoeae undergoes unique, post-translational modifications with these moieties...
  83. doi Novel meningococcal 4CMenB vaccine antigens - prevalence and polymorphisms of the encoding genes in Neisseria gonorrhoeae
    Ronza Hadad
    WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, Sweden
    APMIS 120:750-60. 2012
    ..However, possible cross-immunity of 4CMenB with gonococci and expression and function of the equivalent gonococcal GNAs, as well as of more appropriate GNAs for a gonococcal vaccine, need to be further examined...
  84. pmc Off-target gene regulation mediated by transcriptional repressors of antimicrobial efflux pump genes in Neisseria gonorrhoeae
    Paul J T Johnson
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 55:2559-65. 2011
    ..its ability to repress transcription of the mtrCDE-encoded efflux pump operon in the strict human pathogen Neisseria gonorrhoeae, but recent results from genetic and microarray studies have shown that it can control expression of ..
  85. pmc Mutations affecting peptidoglycan acetylation in Neisseria gonorrhoeae and Neisseria meningitidis
    Joseph P Dillard
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison Medical School, 1300 University Avenue, 471A MSC, Madison, WI 53706, USA
    Infect Immun 73:5697-705. 2005
    b>Neisseria gonorrhoeae acetylates its cell wall peptidoglycan (PG) at the C-6 position on N-acetylmuramic acid...
  86. pmc Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae
    Helen Sarantis
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 80:345-58. 2012
    Symptomatic infection of humans with Neisseria gonorrhoeae is characterized by a neutrophil-rich cervical or urethral exudate, suggesting that neutrophils are important both for the clearance of these bacteria and for the pathogenesis of ..
  87. pmc Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae
    Jason P Folster
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Bacteriol 189:4569-77. 2007
    b>Neisseria gonorrhoeae utilizes the mtrCDE-encoded efflux pump system to resist not only host-derived, hydrophobic antimicrobials that bathe mucosal surfaces, which likely aids in its ability to colonize and infect numerous sites within ..
  88. doi Trends in antimicrobial resistance of Neisseria gonorrhoeae isolated from Korean patients from 2000 to 2006
    Hyukmin Lee
    Department of Laboratory Medicine, Kwandong University College of Medicine, Goyang, Korea
    Sex Transm Dis 38:1082-6. 2011
    The recent emergence and spread of antimicrobial-resistant Neisseria gonorrhoeae has compromised treatment and control of gonorrhea...
  89. doi Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner
    Victor H Ferreira
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON L8N 3Z5, Canada
    J Infect Dis 204:299-308. 2011
    ..Sexually transmitted infections (STIs) are associated with increased human immunodeficiency virus type 1 (HIV-1) susceptibility and viral shedding in the genital tract, but the mechanisms underlying this association are poorly understood...
  90. ncbi Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies
    Kimberly A Workowski
    National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, and Emory University, Atlanta, Georgia, USA
    Ann Intern Med 148:606-13. 2008
    ..Over the past 60 years, however, development of resistance in Neisseria gonorrhoeae to multiple antimicrobial classes challenges this component of gonorrhea control...
  91. ncbi An inhibitor of DNA binding and uptake events dictates the proficiency of genetic transformation in Neisseria gonorrhoeae: mechanism of action and links to Type IV pilus expression
    Finn Erik Aas
    Biotechnology Centre of Oslo, 0317 Oslo, Norway
    Mol Microbiol 46:1441-50. 2002
    ..In Neisseria gonorrhoeae, the Gram-negative aetiologic agent of gonorrhoea, DNA binding and uptake involve components required for ..
  92. pmc Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention
    J Sobngwi-Tambekou
    INSERM U687, Hopital Paul Brousse, Villejuif, France
    Sex Transm Infect 85:116-20. 2009
    To assess the association between male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis using data from a male circumcision randomised controlled trial.
  93. pmc Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine
    Meredith D Hartley
    Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 50:4936-48. 2011
    The O-linked protein glycosylation pathway in Neisseria gonorrhoeae is responsible for the synthesis of a complex oligosaccharide on undecaprenyl diphosphate and subsequent en bloc transfer of the glycan to serine residues of select ..
  94. pmc Evaluation of self-collected vaginal swab, first void urine, and endocervical swab specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in adolescent females
    Junyong Fang
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Pediatr Adolesc Gynecol 21:355-60. 2008
    ..To assess the concordance of self-obtained vaginal swabs (SVS), first void urine samples (FVU) and provider-collected endocervical swabs (PES) for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) in adolescents...
  95. doi Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes
    Magnus Unemo
    Department of Clinical Microbiology, Orebro University Hospital, Sweden
    J Antimicrob Chemother 63:1142-51. 2009
    Emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae remain a major global problem and expanded, but valid, AMR surveillance is crucial for public health purposes...
  96. ncbi Neisseria gonorrhoeae secretes chromosomal DNA via a novel type IV secretion system
    Holly L Hamilton
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Mol Microbiol 55:1704-21. 2005
    ..Recently in Neisseria gonorrhoeae we found that mutations in three genes in the gonococcal genetic island (GGI) reduced the ability of a ..
  97. doi Characterization of profile of multidrug-resistant Neisseria gonorrhoeae using old and new definitions in India over a decade: 2000-2009
    Manju Bala
    Regional STD Teaching, Training and Research Centre, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    Sex Transm Dis 38:1056-8. 2011
    The burden of "multidrug-resistant Neisseria gonorrhoeae" (MDR-NG) was high considering the old definition (26.0%). According to the new definitions, no strain was MDR or extensively drug-resistant...
  98. pmc Low-level pilin expression allows for substantial DNA transformation competence in Neisseria gonorrhoeae
    Cynthia D Long
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Infect Immun 71:6279-91. 2003
    ..We conclude that the pilus assembly apparatus functions to import DNA into the bacterial cell in a pilin-dependent manner but that extended pili are not required for transformation competence...
  99. pmc Force-dependent polymorphism in type IV pili reveals hidden epitopes
    Nicolas Biais
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 107:11358-63. 2010
    ..Whereas the structure of Neisseria gonorrhoeae Tfp has been defined by conventional structural techniques, it remains difficult to explain the wide ..
  100. pmc Frequency and rate of pilin antigenic variation of Neisseria meningitidis
    R Allen Helm
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Bacteriol 192:3822-3. 2010
    ..Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18...
  101. doi Adherence of clinically isolated lactobacilli to human cervical cells in competition with Neisseria gonorrhoeae
    Katarina Vielfort
    Department of Medical Biochemistry and Microbiology, Biomedical Centre, Uppsala University, S 751 23, Uppsala, Sweden
    Microbes Infect 10:1325-34. 2008
    Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea...

Research Grants89

  1. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 2001
    ..In addition, these findings will contribute to the development of effective diagnosis and therapies of human trichomoniasis. ..
  2. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2009
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the ..
  3. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2010
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the ..
  4. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
    ..idiopathic, not attributable to the major sexually transmitted pathogens such as Chlamydia trachomatis or Neisseria gonorrhoeae. Where effective STD control programs exist, most urethritis in men and endocervicitis or mucopurulent ..
  5. PENICILLIN RESISTANT NEISSERIA GONORRHOEAE (CMRNG)
    Robert Nicholas; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Neisseria gonorrhoeae is the causative agent of gonorrhea, an STD that continues to be a public health problem...
  6. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1993
    ....
  7. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..HSV-2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi and Chlamydia trachomatis; b) inactivated bacteria associated ..
  8. Type IV secretion by Neisseria gonorrhoeae
    JOSEPH DILLARD; Fiscal Year: 2005
    b>Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhea, the more serious infections pelvic inflammatory disease (PID) and disseminated gonococcal infection (DGI). We identified a 57 kb genetic island present in N...
  9. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2010
    b>Neisseria gonorrhoeae (Gc) induces an intense inflammatory response that is characterized by the presence of numerous polymorphonuclear leukocytes (PMNs) with intracellular Gc...
  10. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the application abstract) Neisseria gonorrhoeae is one of the two major pathogens involved in the majority of cases of bacterial sexually transmitted genital infection and pelvic inflammatory disease (PID)...
  11. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..of how lipooligosaccharide (LOS) mimicry of human glycosphingolipids (GSL) enables the transmission of Neisseria gonorrhoeae in order to find ways to prevent it...
  12. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2003
    DESCRIPTION (Adapted from the applicant's abstract): Neisseria gonorrhoeae has a serious impact on women=s health due to the frequency with which this pathogen infects the upper reproductive tract, and the resultant serious complications ..
  13. Penicillin-resistant Neisseria gonorrhoeae (CMRNG)
    Robert Nicholas; Fiscal Year: 2005
    Antibiotic resistance in Neisseria gonorrhoeae remains a very important problem...
  14. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    The human pathogen Neisseria gonorrhoeae produces an array of diseases ranging from urethritis and cervicitis to pelvic inflammatory disease. Early events in the establishment of infection involve interactions between N...
  15. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2006
    ..Along with other pathogenic bacteria, antibiotic resistance in Neisseria gonorrhoeae is a growing problem...
  16. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..age group at highest risk for STIs, the CDC recommends annual screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in all sexually active (SA) adolescents, regardless of symptoms...