wolbachia

Summary

Summary: A genus of bacteria comprised of a heterogenous group of gram-negative small rods and coccoid forms associated with arthropods. (From Bergey's Manual of Systematic Bacteriology, vol 1, 1984)

Top Publications

  1. doi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011
  2. doi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
  3. doi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
  4. doi Wolbachia: master manipulators of invertebrate biology
    John H Werren
    Biology Department, University of Rochester, Rochester, New York, New York 14627, USA
    Nat Rev Microbiol 6:741-51. 2008
  5. pmc How many species are infected with Wolbachia?--A statistical analysis of current data
    Kirsten Hilgenboecker
    Institute for Theoretical Biology, Humboldt University Berlin, Berlin, Germany
    FEMS Microbiol Lett 281:215-20. 2008
  6. doi Wolbachia and virus protection in insects
    Lauren M Hedges
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 322:702. 2008
  7. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
  8. ncbi Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
    Julie C Dunning Hotopp
    Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 317:1753-6. 2007
  9. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
  10. doi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009

Detail Information

Publications311 found, 100 shown here

  1. doi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011
    ..It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control...
  2. doi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
    ..Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade ..
  3. doi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
    b>Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species...
  4. doi Wolbachia: master manipulators of invertebrate biology
    John H Werren
    Biology Department, University of Rochester, Rochester, New York, New York 14627, USA
    Nat Rev Microbiol 6:741-51. 2008
    b>Wolbachia are common intracellular bacteria that are found in arthropods and nematodes...
  5. pmc How many species are infected with Wolbachia?--A statistical analysis of current data
    Kirsten Hilgenboecker
    Institute for Theoretical Biology, Humboldt University Berlin, Berlin, Germany
    FEMS Microbiol Lett 281:215-20. 2008
    b>Wolbachia are intracellular bacteria found in many species of arthropods and nematodes...
  6. doi Wolbachia and virus protection in insects
    Lauren M Hedges
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 322:702. 2008
    b>Wolbachia pipientis bacteria are common endosymbionts of insects that are best known for their ability to increase their prevalence in populations by manipulating host reproductive systems...
  7. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
    b>Wolbachia are maternally transmitted symbiotic bacteria that can spread within insect populations because of their unique ability to manipulate host reproduction...
  8. ncbi Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
    Julie C Dunning Hotopp
    Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 317:1753-6. 2007
    ..However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes...
  9. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
    b>Wolbachia inherited bacteria are able to invade insect populations using cytoplasmic incompatibility and provide new strategies for controlling mosquito-borne tropical diseases, such as dengue...
  10. doi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions...
  11. pmc Wolbachia and the biological control of mosquito-borne disease
    Inaki Iturbe-Ormaetxe
    School of Biological Sciences, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    EMBO Rep 12:508-18. 2011
    ..The transinfection of mosquitos with the maternally inherited, endosymbiotic bacteria Wolbachia is a promising new biocontrol approach...
  12. pmc The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..The endosymbiotic bacterium Wolbachia has long been promoted as a potential vehicle for introducing disease-resistance genes into mosquitoes, thereby ..
  13. pmc Wolbachia infections are virulent and inhibit the human malaria parasite Plasmodium falciparum in Anopheles gambiae
    Grant L Hughes
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1002043. 2011
    Endosymbiotic Wolbachia bacteria are potent modulators of pathogen infection and transmission in multiple naturally and artificially infected insect species, including important vectors of human pathogens...
  14. pmc Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
    Zakaria Kambris
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Science 326:134-6. 2009
    b>Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span...
  15. pmc Wolbachia-mediated resistance to dengue virus infection and death at the cellular level
    Francesca D Frentiu
    School of Biological Sciences, The University of Queensland, Brisbane, Australia
    PLoS ONE 5:e13398. 2010
    ..in its primary vector, the mosquito Aedes aegypti, when the insect harbors the endosymbiotic bacterium Wolbachia pipientis...
  16. doi Lymphatic filariasis and onchocerciasis
    Mark J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 376:1175-85. 2010
    ..Most filarial species that infect people co-exist in mutualistic symbiosis with Wolbachia bacteria, which are essential for growth, development, and survival of their nematode hosts...
  17. pmc Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae
    Zakaria Kambris
    Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    PLoS Pathog 6:e1001143. 2010
    The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes...
  18. pmc Multilocus sequence typing system for the endosymbiont Wolbachia pipientis
    Laura Baldo
    Department of Biology, University of California, 900 University Avenue, Riverside, CA 92521, USA
    Appl Environ Microbiol 72:7098-110. 2006
    The eubacterial genus Wolbachia comprises one of the most abundant groups of obligate intracellular bacteria, and it has a host range that spans the phyla Arthropoda and Nematoda...
  19. pmc The native Wolbachia endosymbionts of Drosophila melanogaster and Culex quinquefasciatus increase host resistance to West Nile virus infection
    Robert L Glaser
    Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 5:e11977. 2010
    The bacterial endosymbiont Wolbachia pipientis has been shown to increase host resistance to viral infection in native Drosophila hosts and in the normally Wolbachia-free heterologous host Aedes aegypti when infected by Wolbachia from ..
  20. pmc Still a host of hosts for Wolbachia: analysis of recent data suggests that 40% of terrestrial arthropod species are infected
    Roman Zug
    Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Berlin, Germany
    PLoS ONE 7:e38544. 2012
    b>Wolbachia are intracellular bacteria that manipulate the reproduction of their arthropod hosts in remarkable ways. They are predominantly transmitted vertically from mother to offspring but also occasionally horizontally between species...
  21. pmc Persistent Wolbachia and cultivable bacteria infection in the reproductive and somatic tissues of the mosquito vector Aedes albopictus
    Karima Zouache
    Universite de Lyon, Lyon, France
    PLoS ONE 4:e6388. 2009
    ..This study investigated Wolbachia and cultivable bacteria that persist through generations in Ae...
  22. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
    The non-virulent Wolbachia strain wMel and the life-shortening strain wMelPop-CLA, both originally from Drosophila melanogaster, have been stably introduced into the mosquito vector of dengue fever, Aedes aegypti...
  23. pmc Evidence for metabolic provisioning by a common invertebrate endosymbiont, Wolbachia pipientis, during periods of nutritional stress
    Jeremy C Brownlie
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000368. 2009
    b>Wolbachia are ubiquitous inherited endosymbionts of invertebrates that invade host populations by modifying host reproductive systems...
  24. pmc New insights into the evolution of Wolbachia infections in filarial nematodes inferred from a large range of screened species
    Emanuele Ferri
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Milano, Italy
    PLoS ONE 6:e20843. 2011
    b>Wolbachia are intriguing symbiotic endobacteria with a peculiar host range that includes arthropods and a single nematode family, the Onchocercidae encompassing agents of filariases...
  25. doi The genetics and cell biology of Wolbachia-host interactions
    Laura R Serbus
    Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Annu Rev Genet 42:683-707. 2008
    b>Wolbachia are gram-negative bacteria that are widespread in nature, carried by the majority of insect species as well as some mites, crustaceans, and filarial nematodes...
  26. pmc Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans
    Uzma Alam
    Yale University, School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002415. 2011
    ..One such drive mechanism results from the cytoplasmic incompatibility (CI) phenomenon induced by the symbiont Wolbachia. CI can also be used to induce natural mating incompatibility between release males and natural populations...
  27. pmc Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 5:e11029. 2010
    b>Wolbachia are among the most abundant symbiotic microbes on earth; they are present in about 66% of all insect species, some spiders, mites and crustaceans, and most filarial nematode species...
  28. pmc The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster
    Luis Teixeira
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e2. 2008
    b>Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes...
  29. doi Phylogeography of Nasonia vitripennis (Hymenoptera) indicates a mitochondrial-Wolbachia sweep in North America
    R Raychoudhury
    Department of Biology, University of Rochester, Rochester, NY 14267, USA
    Heredity (Edinb) 104:318-26. 2010
    Here we report evidence of a mitochondrial-Wolbachia sweep in North American populations of the parasitoid wasp Nasonia vitripennis, a cosmopolitan species and emerging model organism for evolutionary and genetic studies...
  30. pmc Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila
    Zhee Sheen Wong
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 6:e25430. 2011
    ..Recently the maternally inherited endosymbiotic bacteria Wolbachia has been shown to protect insects from a range of microbial and eukaryotic pathogens...
  31. doi Adaptation via symbiosis: recent spread of a Drosophila defensive symbiont
    John Jaenike
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 329:212-5. 2010
    ..These findings demonstrate the profound and potentially rapid effects of defensive symbionts, which are increasingly recognized as major players in the ecology of species interactions...
  32. pmc Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans
    Sheree E Osborne
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000656. 2009
    ..The Drosophila host is also commonly infected with the widespread endosymbiotic bacteria Wolbachia pipientis. When DCV coinfects Wolbachia-infected D...
  33. pmc Complete WO phage sequences reveal their dynamic evolutionary trajectories and putative functional elements required for integration into the Wolbachia genome
    Kohjiro Tanaka
    National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 75:5676-86. 2009
    b>Wolbachia endosymbionts are ubiquitously found in diverse insects including many medical and hygienic pests, causing a variety of reproductive phenotypes, such as cytoplasmic incompatibility, and thereby efficiently spreading in host ..
  34. doi Wolbachia: more than just a bug in insects genitals
    Aggeliki Saridaki
    Department of Environmental and Natural Resources Management, University of Ioannina, Agrinio, Greece
    Curr Opin Microbiol 13:67-72. 2010
    Research on the intracellular bacterial symbiont Wolbachia has grown on many levels, providing interesting insights on various aspects of the microbe's biology...
  35. pmc Wolbachia induces density-dependent inhibition to dengue virus in mosquito cells
    Peng Lu
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
    PLoS Negl Trop Dis 6:e1754. 2012
    b>Wolbachia is a maternal transmitted endosymbiotic bacterium that is estimated to infect up to 65% of insect species...
  36. pmc Impact of Wolbachia on infection with chikungunya and yellow fever viruses in the mosquito vector Aedes aegypti
    Andrew F van den Hurk
    Public Health Virology, Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, Coopers Plains, Australia
    PLoS Negl Trop Dis 6:e1892. 2012
    ..When transinfected into Ae. aegypti, the intracellular bacterium Wolbachia has recently been shown to inhibit replication of DENVs, CHIKV, malaria parasites and filarial nematodes, ..
  37. pmc Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
    Clin Microbiol Rev 24:459-68. 2011
    The discovery of Wolbachia intracellular bacteria within filarial nematodes, including Onchocerca volvulus, the causative agent of onchocerciasis or "river blindness," has delivered a paradigm shift in our understanding of the parasite's ..
  38. pmc Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti
    Lisa Klasson
    Department of Zoology, University of Oxford, Oxford, UK
    BMC Genomics 10:33. 2009
    The evolutionary importance of horizontal gene transfer (HGT) from Wolbachia endosymbiotic bacteria to their eukaryotic hosts is a topic of considerable interest and debate...
  39. pmc Tissue and stage-specific distribution of Wolbachia in Brugia malayi
    Kerstin Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 5:e1174. 2011
    Most filarial parasite species contain Wolbachia, obligatory bacterial endosymbionts that are crucial for filarial development and reproduction...
  40. pmc Lutzomyia sand fly diversity and rates of infection by Wolbachia and an exotic Leishmania species on Barro Colorado Island, Panama
    Jorge Azpurua
    Smithsonian Tropical Research Institute, Panama, Republica de Panama
    PLoS Negl Trop Dis 4:e627. 2010
    ..a microbe that can potentially serve in vector population control, the cytoplasmically transmitted rickettsia, Wolbachia pipientis...
  41. pmc Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom
    J Biol Chem 284:22364-78. 2009
    b>Wolbachia endosymbiotic bacteria have been implicated in the inflammatory pathogenesis of filariasis...
  42. doi Prevalence of endosymbionts in Bemisia tabaci populations and their in vivo sensitivity to antibiotics
    Muhammad Z Ahmed
    Department of Entomology, South China Agricultural University, Guangzhou 510640, People s Republic of China
    Curr Microbiol 61:322-8. 2010
    ..the prevalence of the primary endosymbiont Portiera aleyrodidarum and secondary endosymbionts Arsenophonus and Wolbachia in two invasive biotypes (B and Q) and one indigenous biotype (Cv) in China and (2) the in vivo effect of three ..
  43. pmc The joint evolutionary histories of Wolbachia and mitochondria in Hypolimnas bolina
    Sylvain Charlat
    CNRS UMR 5558, University of Lyon 1, Laboratoire de Biometrie et Biologie Evolutive, Batiment Mendel, Villeurbanne, France
    BMC Evol Biol 9:64. 2009
    The interaction between the Blue Moon butterfly, Hypolimnas bolina, and Wolbachia has attracted interest because of the high prevalence of male-killing achieved within the species, the ecological consequences of this high prevalence, the ..
  44. pmc Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases
    Penelope A Hancock
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Negl Trop Dis 5:e1024. 2011
    Certain strains of the endosymbiont Wolbachia have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases...
  45. pmc Extensive genomic diversity of closely related Wolbachia strains
    Nadeeza Ishmael
    J Craig Venter Institute, 9708 Medical Center Dr, Rockville, MD 20850, USA
    Microbiology 155:2211-22. 2009
    Using microarray-based comparative genome hybridization (mCGH), the genomic content of Wolbachia pipientis wMel from Drosophila melanogaster was compared to the closely related Wolbachia from D. innubila (wInn), D...
  46. pmc Phage WO of Wolbachia: lambda of the endosymbiont world
    Bethany N Kent
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Trends Microbiol 18:173-81. 2010
    The discovery of an extraordinarily high level of mobile elements in the genome of Wolbachia, a widespread arthropod and nematode endosymbiont, suggests that this bacterium could be an excellent model for assessing the evolution and ..
  47. pmc The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans
    Lisa Klasson
    Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 106:5725-30. 2009
    The obligate intracellular bacterium Wolbachia pipientis infects around 20% of all insect species...
  48. pmc Complete bacteriophage transfer in a bacterial endosymbiont (Wolbachia) determined by targeted genome capture
    Bethany N Kent
    Department of Biological Sciences, Vanderbilt University, USA
    Genome Biol Evol 3:209-18. 2011
    ..as single genes or larger regions between coinfections, we sequenced the genome of the obligate intracellular Wolbachia strain wVitB from the parasitic wasp Nasonia vitripennis and compared it against the prophage sequences of the ..
  49. ncbi Wolbachia modulates Chikungunya replication in Aedes albopictus
    L Mousson
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, F 75724 Paris Cedex 15, France
    Mol Ecol 19:1953-64. 2010
    ..The species is naturally infected by two strains of Wolbachia (wAlbA and wAlbB)...
  50. pmc Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:9649-54. 2011
    ..The analysis also yielded much of the proteome of Wolbachia, the obligate endosymbiont of Bm that also expressed proteins in a stage-specific manner...
  51. ncbi Wolbachia establishment and invasion in an Aedes aegypti laboratory population
    Zhiyong Xi
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    Science 310:326-8. 2005
    ..Endosymbiotic Wolbachia bacteria are potential transgene drivers, but infections do not naturally occur in some important mosquito ..
  52. pmc Wolbachia density and virulence attenuation after transfer into a novel host
    E A McGraw
    Section of Vector Biology, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:2918-23. 2002
    The factors that control replication rate of the intracellular bacterium Wolbachia pipientis in its insect hosts are unknown and difficult to explore, given the complex interaction of symbiont and host genotypes...
  53. ncbi Widespread recombination throughout Wolbachia genomes
    Laura Baldo
    Department of Biology, University of California, Riverside, USA
    Mol Biol Evol 23:437-49. 2006
    ..Here we investigate the extent of recombination among housekeeping genes of the endosymbiotic bacteria Wolbachia. Four housekeeping genes, gltA, dnaA, ftsZ, and groEL, were sequenced from a sample of 22 strains belonging to ..
  54. pmc Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wolbachia
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Negl Trop Dis 3:e568. 2009
    ..Alternative strategies include the proposed use of inherited life-shortening agents, such as the Wolbachia bacterium...
  55. pmc Nonrandom Wolbachia infection status of Drosophila melanogaster strains with different mtDNA haplotypes
    Maria D S Nunes
    Institut für Populationsgenetik, Veterinärmedizinische Universität Wien, Veterinarplatz 1, Vienna, Austria
    Mol Biol Evol 25:2493-8. 2008
    b>Wolbachia are maternally inherited bacteria, which typically spread in the host population by inducing cytoplasmic incompatibility (CI)...
  56. pmc Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes
    Frédéric Landmann
    Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California, Santa Cruz, California, United States of America
    PLoS Pathog 7:e1002351. 2011
    Filarial nematodes maintain a mutualistic relationship with the endosymbiont Wolbachia. Depletion of Wolbachia produces profound defects in nematode development, fertility and viability and thus has great promise as a novel approach for ..
  57. pmc Artificial triple Wolbachia infection in Aedes albopictus yields a new pattern of unidirectional cytoplasmic incompatibility
    Yuqing Fu
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    Appl Environ Microbiol 76:5887-91. 2010
    Obligately intracellular Wolbachia bacteria infect numerous invertebrates and often manipulate host reproduction to facilitate the spread of infection...
  58. doi Regulation of Wolbachia ankyrin domain encoding genes in Drosophila gonads
    George Papafotiou
    Institute of Cellular and Developmental Biology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Res Microbiol 162:764-72. 2011
    The maternally inherited obligatory intracellular bacterium Wolbachia is a reproductive parasite of many insect species...
  59. doi Heartworm and Wolbachia: therapeutic implications
    J W McCall
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
    Vet Parasitol 158:204-14. 2008
    ..Preliminary observations suggest that administration of DOXY+IVM for several months prior to (or without) MEL will eliminate adult HW with less potential for severe thromboembolism than MEL alone...
  60. doi Wolbachia in a major African crop pest increases susceptibility to viral disease rather than protects
    Robert I Graham
    Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK
    Ecol Lett 15:993-1000. 2012
    b>Wolbachia are common vertically transmitted endosymbiotic bacteria found in < 70% of insect species...
  61. pmc Short- and long-term evolutionary dynamics of bacterial insertion sequences: insights from Wolbachia endosymbionts
    Nicolas Cerveau
    UMR CNRS 6556, Ecologie, Evolution, Symbiose, Universite de Poitiers, France
    Genome Biol Evol 3:1175-86. 2011
    ..We found that Wolbachia bacterial genomes contain 52-171 insertion sequence (IS) TEs...
  62. ncbi Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp. in Southern Germany
    Kathrin Hartelt
    Baden Wuerttemberg State Health Office, Stuttgart, Germany
    Int J Med Microbiol 293:86-92. 2004
    ..9%) were identified as Wolbachia sp. Rickettsia sp. in Ixodes ricinus ticks from 3 areas were found in n = 105 (8...
  63. pmc Wolbachia strain wAlbB enhances infection by the rodent malaria parasite Plasmodium berghei in Anopheles gambiae mosquitoes
    Grant L Hughes
    Department of Entomology, The Pennsylvania State University, University Park, PA, USA
    Appl Environ Microbiol 78:1491-5. 2012
    b>Wolbachia, a common bacterial endosymbiont of insects, has been shown to protect its hosts against a wide range of pathogens. However, not all strains exert a protective effect on their host...
  64. pmc Genetic and functional characterization of the type IV secretion system in Wolbachia
    Edwige Rancès
    Universite de Lyon, Lyon, France
    J Bacteriol 190:5020-30. 2008
    ..In this study, the presence and function of the T4SS in Wolbachia strains were investigated by a combination of genetic screening and immunofluorescence microscopy...
  65. pmc The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode
    Jeremy Foster
    Molecular Parasitology Division, New England Biolabs, Beverly, Massachusetts, USA
    PLoS Biol 3:e121. 2005
    Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi...
  66. pmc Wolbachia-mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus
    Frédéric Landmann
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, USA
    PLoS Pathog 5:e1000343. 2009
    b>Wolbachia is a bacteria endosymbiont that rapidly infects insect populations through a mechanism known as cytoplasmic incompatibility (CI)...
  67. pmc Genome evolution of Wolbachia strain wPip from the Culex pipiens group
    Lisa Klasson
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 25:1877-87. 2008
    The obligate intracellular bacterium Wolbachia pipientis strain wPip induces cytoplasmic incompatibility (CI), patterns of crossing sterility, in the Culex pipiens group of mosquitoes. The complete sequence is presented of the 1...
  68. pmc Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues
    Frédéric Landmann
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS Negl Trop Dis 4:e758. 2010
    b>Wolbachia are required for filarial nematode survival and fertility and contribute to the immune responses associated with human filarial diseases...
  69. ncbi Isolation and characterization of the bacteriophage WO from Wolbachia, an arthropod endosymbiont
    Yukiko Fujii
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 317:1183-8. 2004
    b>Wolbachia is a group of obligate symbiotic bacteria found in many insects and other arthropods. The presence of Wolbachia alters reproduction in the host, but the mechanisms are unknown...
  70. ncbi Biotype-dependent secondary symbiont communities in sympatric populations of Bemisia tabaci
    E Chiel
    Department of Entomology, Newe Ya ar Research Center, ARO, Ramat Yishai 30095, Israel
    Bull Entomol Res 97:407-13. 2007
    ..an obligatory symbiotic bacterium, as well as several secondary symbionts including Rickettsia, Hamiltonella, Wolbachia, Arsenophonus, Cardinium and Fritschea, the function of which is unknown...
  71. ncbi Specialization and geographic isolation among Wolbachia symbionts from ants and lycaenid butterflies
    Jacob A Russell
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 63:624-40. 2009
    b>Wolbachia are the most prevalent and influential bacteria described among the insects to date. But despite their significance, we lack an understanding of their evolutionary histories...
  72. pmc The tripartite associations between bacteriophage, Wolbachia, and arthropods
    Seth R Bordenstein
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    PLoS Pathog 2:e43. 2006
    By manipulating arthropod reproduction worldwide, the heritable endosymbiont Wolbachia has spread to pandemic levels...
  73. ncbi Bacteriophage flux in endosymbionts (Wolbachia): infection frequency, lateral transfer, and recombination rates
    Seth R Bordenstein
    The Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, USA
    Mol Biol Evol 21:1981-91. 2004
    ..been influential in the genome evolution of the most prevalent bacterial endosymbiont of invertebrates, Wolbachia. First, we show that bacteriophage WO is more widespread in Wolbachia than previously recognized, occurring in ..
  74. ncbi Wolbachia distribution and cytoplasmic incompatibility during sperm development: the cyst as the basic cellular unit of CI expression
    Michael E Clark
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Mech Dev 120:185-98. 2003
    The growth and distribution of the intracellular microbe Wolbachia pipientis during spermatogenesis in several different host/symbiont genetic combinations in Drosophila melanogaster and Drosophila simulans is described...
  75. ncbi Diversity, distribution and specificity of WO phage infection in Wolbachia of four insect species
    L Gavotte
    Laboratoire de Biometrie et Biologie Evolutive, Université Lyon I CNRS, Villeurbanne, France
    Insect Mol Biol 13:147-53. 2004
    The bacteriophage WO was recently characterized in Wolbachia, a strictly intracellular bacterium that causes several reproductive alterations in its arthropod hosts...
  76. ncbi Strain-specific regulation of intracellular Wolbachia density in multiply infected insects
    L Mouton
    Laboratoire de Biometrie et Biologie Evolutive, Universite Claude Bernard, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Mol Ecol 12:3459-65. 2003
    ..b>Wolbachia endosymbionts that induce cytoplasmic incompatibility in their hosts depart from this rule, because cytoplasmic ..
  77. pmc Increased locomotor activity and metabolism of Aedes aegypti infected with a life-shortening strain of Wolbachia pipientis
    Oliver Evans
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, 4072, Australia
    J Exp Biol 212:1436-41. 2009
    A virulent strain of the obligate intracellular bacterium Wolbachia pipientis that shortens insect lifespan has recently been transinfected into the primary mosquito vector of dengue virus, Aedes aegypti L...
  78. doi An endosymbiotic bacterium in a plant-parasitic nematode: member of a new Wolbachia supergroup
    Annelies Haegeman
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    Int J Parasitol 39:1045-54. 2009
    b>Wolbachia is an endosymbiotic bacterium widely present in arthropods and animal-parasitic nematodes. Despite previous efforts, it has never been identified in plant-parasitic nematodes...
  79. pmc Wolbachia infection frequencies in insects: evidence of a global equilibrium?
    J H Werren
    Department of Biology, University of Rochester, NY 14627, USA
    Proc Biol Sci 267:1277-85. 2000
    b>Wolbachia are a group of cytoplasmically inherited bacteria that cause reproduction alterations in arthropods, including parthenogenesis, reproductive incompatibility, feminization of genetic males and male killing...
  80. doi Remarkable abundance and evolution of mobile group II introns in Wolbachia bacterial endosymbionts
    Sébastien Leclercq
    Centre National de la Recherche Scientifique UMR 6556 Ecologie, Evolution, Symbiose, Universite de Poitiers, Poitiers, France
    Mol Biol Evol 28:685-97. 2011
    ..Yet, the genomes of Wolbachia, one of the most abundant bacterial endosymbionts on Earth, are littered with transposable elements, in ..
  81. ncbi Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
    Beate Henrichfreise
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Mol Microbiol 73:913-23. 2009
    ..Genes for enzymes of both machineries have been found in the genomes of the cell wall-less genera Chlamydia and Wolbachia, raising questions as to the functionality of the lipid II biosynthesis pathway and reasons for its conservation...
  82. ncbi Wolbachia pipientis: an expanding bag of tricks to explore for disease control
    Peter E Cook
    School of Biological Sciences, The University of Queensland, Brisbane, Australia
    Trends Parasitol 26:373-5. 2010
    b>Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects...
  83. pmc Wolbachia-induced cytoplasmic incompatibility as a means for insect pest population control
    Sofia Zabalou
    Department of Medical Sciences, Medical School, University of Crete, Heraklion 711 10, Crete, Greece
    Proc Natl Acad Sci U S A 101:15042-5. 2004
    ..b>Wolbachia are inherited bacteria of arthropods that have recently attracted attention for their potential as new ..
  84. pmc The genome of Brugia malayi - all worms are not created equal
    Alan L Scott
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Parasitol Int 58:6-11. 2009
    ..genetic basis for mutualism, as Brugia, like a majority of filarial species, harbors an endosybiotic bacterium (Wolbachia)...
  85. ncbi Symbiont genes in host genomes: fragments with a future?
    Mark Blaxter
    Institute of Evolutionary Biology, School of Biological Sciences, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
    Cell Host Microbe 2:211-3. 2007
    ..Germline-transmitted animal symbionts, such as Wolbachia pipientis, are well placed to participate in such transfers. In a recent issue of Science, Dunning Hotopp et al...
  86. ncbi Long PCR improves Wolbachia DNA amplification: wsp sequences found in 76% of sixty-three arthropod species
    A Jeyaprakash
    Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USA
    Insect Mol Biol 9:393-405. 2000
    Bacteria belonging to the genus Wolbachia are associated with a variety of reproductive anomalies in arthropods. Allele-specific polymerase chain reaction (= Standard PCR) routinely has been used to amplify Wolbachia DNA from arthropods...
  87. pmc Intense transpositional activity of insertion sequences in an ancient obligate endosymbiont
    Richard Cordaux
    CNRS UMR 6556 Ecologie, Evolution, Symbiose, Universite de Poitiers, Poitiers, France
    Mol Biol Evol 25:1889-96. 2008
    ..Yet, the genome of Wolbachia, one of the most abundant bacterial endosymbionts on Earth, is littered with IS...
  88. pmc Multiple rescue factors within a Wolbachia strain
    Sofia Zabalou
    Institute of Molecular Biology and Biotechnology, FORTH, Vassilika Vouton, Heraklion 71110, Crete, Greece
    Genetics 178:2145-60. 2008
    b>Wolbachia-induced cytoplasmic incompatibility (CI) is expressed when infected males are crossed with either uninfected females or females infected with Wolbachia of different CI specificity...
  89. pmc Wolbachia as a bacteriocyte-associated nutritional mutualist
    Takahiro Hosokawa
    National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Proc Natl Acad Sci U S A 107:769-74. 2010
    ..Facultative and parasitic bacterial symbionts like Wolbachia have been regarded as evolutionarily distinct from such obligate nutritional mutualists...
  90. ncbi Somatic stem cell niche tropism in Wolbachia
    Horacio M Frydman
    Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08540, USA
    Nature 441:509-12. 2006
    b>Wolbachia are intracellular bacteria found in the reproductive tissue of all major groups of arthropods. They are transmitted vertically from the female hosts to their offspring, in a pattern analogous to mitochondria inheritance...
  91. ncbi A Survey of the bacteriophage WO in the endosymbiotic bacteria Wolbachia
    Laurent Gavotte
    Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS, IFR 41, University Lyon 1, Villeurbanne, France
    Mol Biol Evol 24:427-35. 2007
    ..However, Wolbachia, an intracellular alpha-proteobacterium, infecting diverse arthropod and nematode species and best known for the ..
  92. ncbi ISWpi1 from Wolbachia pipientis defines a novel group of insertion sequences within the IS5 family
    Richard Cordaux
    Laboratoire de Génétique et Biologie des Populations de Crustacés, CNRS UMR 6556, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    Gene 409:20-7. 2008
    ..which the taxonomic distribution appears to be restricted to the obligate intracellular alpha-Proteobacterium Wolbachia pipientis...
  93. ncbi Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria
    N W Brattig
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Microbes Infect 6:113-28. 2004
    ..The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore emerging as a novel target for chemotherapy...
  94. ncbi Bacteriophage WO and virus-like particles in Wolbachia, an endosymbiont of arthropods
    S Masui
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 283:1099-104. 2001
    b>Wolbachia are intracellular symbionts mainly found in arthropods, causing various sexual alterations on their hosts by unknown mechanisms...
  95. doi Wolbachia-based technologies for insect pest population control
    Kostas Bourtzis
    Department of Environmental and Natural Resources Management, University of Ioannina, 30100 Agrinio, Greece
    Adv Exp Med Biol 627:104-13. 2008
    b>Wolbachia are a group of obligatory intracellular and maternally inherited bacteria found in many arthropod species, including insects, mites, spiders, springtails, crustaceans, as well as in certain nematodes...
  96. ncbi The rate of recombination in Wolbachia bacteria
    Francis M Jiggins
    Department of Genetics, University of Cambridge, UK
    Mol Biol Evol 19:1640-3. 2002
  97. pmc Coexistence of Wolbachia with Buchnera aphidicola and a secondary symbiont in the aphid Cinara cedri
    Laura Gomez-Valero
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    J Bacteriol 186:6626-33. 2004
    ..previously found to be associated with aphids (PASS, or R type) and an alpha-proteobacterium that belongs to the Wolbachia genus...
  98. pmc Parasitism and mutualism in Wolbachia: what the phylogenomic trees can and cannot say
    Seth R Bordenstein
    Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA
    Mol Biol Evol 26:231-41. 2009
    ..b>Wolbachia is an inherited obligate, intracellular infection of invertebrates containing taxa that act broadly as both ..
  99. pmc Infectious speciation revisited: impact of symbiont-depletion on female fitness and mating behavior of Drosophila paulistorum
    Wolfgang J Miller
    Laboratories of Genome Dynamics, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    PLoS Pathog 6:e1001214. 2010
    ..candidates fostering symbiont-driven speciation in arthropods are intracellular bacteria belonging to the genus Wolbachia. They are maternally inherited symbionts of many arthropods capable of manipulating host reproductive biology ..
  100. ncbi Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi
    S Townson
    Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, UK
    Ann Trop Med Parasitol 94:801-16. 2000
    ..to study the effects of rifampicin and oxytetracycline on filarial tissues and on the endosymbiont bacterium, Wolbachia. When tested in vitro at a concentration of 50...
  101. pmc Wolbachia interferes with ferritin expression and iron metabolism in insects
    Natacha Kremer
    Universite de Lyon, Lyon, France
    PLoS Pathog 5:e1000630. 2009
    b>Wolbachia is an intracellular bacterium generally described as being a facultative reproductive parasite. However, Wolbachia is necessary for oogenesis completion in the wasp Asobara tabida...

Research Grants99

  1. Development of a novel nematode/Wolbachia target
    Clotilde Carlow; Fiscal Year: 2007
    ..This will provide the basis for discovering a new class of drugs that may be used in veterinary and human medicine. [unreadable] [unreadable]..
  2. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2007
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  3. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2007
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  4. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2005
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  5. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2006
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  6. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2004
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  7. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2004
    ..previously classified as Wolbachia sp.) common within tissues of dog ticks, Dermacentor variabilis...
  8. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2003
    ..previously classified as Wolbachia sp.) common within tissues of dog ticks, Dermacentor variabilis...
  9. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2003
    ..specific innate immune receptors, including toll-like receptors (tlr) that are activated by filarial and Wolbachia products...
  10. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2006
    ..specific innate immune receptors, including toll-like receptors (tlr) that are activated by filarial and Wolbachia products...
  11. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2004
    ..specific innate immune receptors, including toll-like receptors (tlr) that are activated by filarial and Wolbachia products...
  12. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2005
    ..specific innate immune receptors, including toll-like receptors (tlr) that are activated by filarial and Wolbachia products...
  13. The molecular basis of bacteria-host interaction Drosophila melanogaster
    LAURA SERBUS; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): One of the most successful intracellular bacteria is Wolbachia, harbored by thousands of arthropods and nematodes...
  14. Biological vector control reducing arboviruses, including Dengue and Chikungunya
    JAMES WILLIAM MAINS; Fiscal Year: 2012
    ..In brief, the strategy is to release Ae. albopictus males that are infected with Wolbachia bacteria, which effectively sterilize the mates of the released males...
  15. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2005
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  16. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2002
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  17. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2003
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  18. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2004
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  19. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2005
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  20. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2006
    ..by this new research program include both the unique AARS expressed in filarial parasites and those within the Wolbachia endosymbiotic bacteria that are essential for worm viability...
  21. Genetic and genomic tools for the emerging model organsism, Nasonia
    JOHN HAYNES WERREN; Fiscal Year: 2010
    ..of isogenic lines, and the four species in the genus are inter-fertile (after removal of the endosymbiont Wolbachia), facilitating movement of genes between the species for efficient positional cloning of quantitative trait loci ..
  22. Genetic and genomic tools for the emerging model organsism, Nasonia
    JOHN HAYNES WERREN; Fiscal Year: 2010
    ..of isogenic lines, and the four species in the genus are inter-fertile (after removal of the endosymbiont Wolbachia), facilitating movement of genes between the species for efficient positional cloning of quantitative trait loci ..
  23. Genetic and genomic tools for the emerging model organsism, Nasonia
    John Werren; Fiscal Year: 2009
    ..of isogenic lines, and the four species in the genus are inter-fertile (after removal of the endosymbiont Wolbachia), facilitating movement of genes between the species for efficient positional cloning of quantitative trait loci ..
  24. In vitro culture and transformation of Wolbachia from mosquitoes
    Ann Fallon; Fiscal Year: 2006
    ..The intracellular bacterium, Wolbachia pipientis, provides an attractive drive mechanism, because it favors its own transmission through a reproductive ..
  25. Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
    Thomas R Unnasch; Fiscal Year: 2010
    ..Most of the human filarial parasite species harbor an endosymbiotic bacterium of the genus Wolbachia. These endo-bacteria are essential, as elimination of the endosymbiont leads to sterilization of the adult ..
  26. Molecular Mechanism of Cytoplasmic Incompatibility in Mosquitoes
    Zhiyong Xi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The endosymbiotic bacterium Wolbachia is widely recognized for its potential as a vehicle to introduce disease-resistance genes into mosquitoes, making them refractory to the human pathogens they ..
  27. Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
    THOMAS UNNASCH; Fiscal Year: 2009
    ..Most of the human filarial parasite species harbor an endosymbiotic bacterium of the genus Wolbachia. These endo-bacteria are essential, as elimination of the endosymbiont leads to sterilization of the adult ..
  28. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2007
    ..3) engineered underdominance, 4) insertion of loaded autonomous transposons, 5) infection with transgenic Wolbachia strains. The potential for using novel transgenic manipulations will be examined with more general models...
  29. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2006
    ..3) engineered underdominance, 4) insertion of loaded autonomous transposons, 5) infection with transgenic Wolbachia strains. The potential for using novel transgenic manipulations will be examined with more general models...
  30. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2004
    ..3) engineered underdominance, 4) insertion of loaded autonomous transposons, 5) infection with transgenic Wolbachia strains. The potential for using novel transgenic manipulations will be examined with more general models...
  31. Host-pathogen interactions in targeting Wolbachia to the stem cell niche
    Horacio Frydman; Fiscal Year: 2009
    Although Wolbachia infections are found in most Arthropods and are of clinical importance in many parasitic diseases, very little is known about the cellular mechanisms responsible for their transmission...
  32. Host-pathogen interactions in targeting Wolbachia to the stem cell niche
    Horacio M Frydman; Fiscal Year: 2010
    Although Wolbachia infections are found in most Arthropods and are of clinical importance in many parasitic diseases, very little is known about the cellular mechanisms responsible for their transmission...
  33. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2010
    ..into natural tsetse populations by cytoplasmic incompatibility phenomenon mediated by tsetse's symbiont, Wolbachia. We propose to investigate the biogeography of the human disease vector species, Glossina fuscipes fuscipes, its ..
  34. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2009
    ..into natural tsetse populations by cytoplasmic incompatibility phenomenon mediated by tsetse's symbiont, Wolbachia. We propose to investigate the biogeography of the human disease vector species, Glossina fuscipes fuscipes, its ..
  35. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2010
    ..into natural tsetse populations by cytoplasmic incompatibility phenomenon mediated by tsetse's symbiont, Wolbachia. We propose to investigate the biogeography of the human disease vector species, Glossina fuscipes fuscipes, its ..
  36. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2005
    ..3) engineered underdominance, 4) insertion of loaded autonomous transposons, 5) infection with transgenic Wolbachia strains. The potential for using novel transgenic manipulations will be examined with more general models...
  37. Impact of Bacterial-Animal Lateral Gene Transfer on Human Health
    JULIE HOTOPP; Fiscal Year: 2010
    ..Filarial nematodes (the causative agents) are known to acquire DNA from their bacterial endosymbionts, Wolbachia. Although in some nematodes Wolbachia are obligate endosymbionts, other lineages lack Wolbachia...
  38. COMPARATIVE WOLBACHIA GENOME SEQUENCING
    Serap Aksoy; Fiscal Year: 2000
    The objective of this grant is to sequence the genomes of three related Wolbachia strains...
  39. REGULATION OF SEX SPECIFIC GENES IN DROSOPHILA
    Thomas Cline; Fiscal Year: 2003
    ..is sought of how and why Sxl functions in germ cells and how the obligate intracellular parasitic bacterium Wolbachia pipientis interacts with it in that cell type...
  40. REGULATION OF SEX SPECIFIC GENES IN DROSOPHILA
    Thomas Cline; Fiscal Year: 2006
    ..is sought of how and why Sxl functions in germ cells and how the obligate intracellular parasitic bacterium Wolbachia pipientis interacts with it in that cell type...
  41. REGULATION OF SEX SPECIFIC GENES IN DROSOPHILA
    Thomas Cline; Fiscal Year: 2005
    ..is sought of how and why Sxl functions in germ cells and how the obligate intracellular parasitic bacterium Wolbachia pipientis interacts with it in that cell type...
  42. REGULATION OF SEX SPECIFIC GENES IN DROSOPHILA
    Thomas Cline; Fiscal Year: 2004
    ..is sought of how and why Sxl functions in germ cells and how the obligate intracellular parasitic bacterium Wolbachia pipientis interacts with it in that cell type...
  43. TRANS-INFECTION OF MOSQUITOES WITH WOLBACHIA PIPIENTIS
    SCOTT O NEILL; Fiscal Year: 1993
    ..on utilizing the reproductive advantage accrued to insects that carry the intracellular bacterial symbiont, Wolbachia pipientis, as a means to drive desirable genes into natural insect vector populations...
  44. Development of a novel nematode/Wolbachia target
    Clotilde Carlow; Fiscal Year: 2006
    ..This will provide the basis for discovering a new class of drugs that may be used in veterinary and human medicine. [unreadable] [unreadable]..
  45. Development of a novel nematode/Wolbachia target
    Clotilde Carlow; Fiscal Year: 2004
    ..large-scale production of recombinant target isolated from several nematodes and their endosymbiotic bacteria Wolbachia. In addition, high throughput screens will be developed and established for the screening of inhibitors...
  46. WOLBACHIA INFECTIONS AS A VEHICLE FOR GENOME REPLACEMENT
    SCOTT O NEILL; Fiscal Year: 2000
    ..The project will focus on Wolbachia-mediated cytoplasmic incompatibility as a gene driving system which could be used in many different insect ..
  47. WOLBACHIA INFECTIONS AS A VEHICLE FOR GENOME REPLACEMENT
    SCOTT O NEILL; Fiscal Year: 1999
    ..The project will focus on Wolbachia-mediated cytoplasmic incompatibility as a gene driving system which could be used in many different insect ..
  48. Molecular Evolution and Life Cycle of Wolbachia Bacteriohage
    Seth Bordenstein; Fiscal Year: 2008
    b>Wolbachia pipientis is one of the most prevalent obligate, intracellular bacteria in multicellular animals...
  49. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    Stephen Dobson; Fiscal Year: 2006
    ..Here, we propose a novel strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission...
  50. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    Stephen Dobson; Fiscal Year: 2008
    ..Here, we propose a novel strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission...
  51. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    Stephen Dobson; Fiscal Year: 2007
    ..Here, we propose a novel strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission...
  52. Vector Population Modification Using Wolbachia Symbionts
    Stephen Dobson; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Intracellular Wolbachia bacteria infect a diverse range of invertebrate hosts, including medically important disease vectors...
  53. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    STEPHEN LEONARD DOBSON; Fiscal Year: 2010
    ..Here, we propose a novel strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission...
  54. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    Stephen Dobson; Fiscal Year: 2009
    ..Here, we propose a novel strategy in which releases of male Ae. polynesiensis mosquitoes infected with Wolbachia bacteria result in the sterilization of female mosquitoes at a field site endemic for filariasis transmission...
  55. Vector Population Modification Using Wolbachia Symbionts
    Stephen Dobson; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Intracellular Wolbachia bacteria infect a diverse range of invertebrate hosts, including medically important disease vectors...
  56. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 1990
    ..These studies will contribute to an increased understanding of the genetics and physiology of the mosquito, a disease vector with considerable impact on human health and productivity...
  57. Genetic basis of WNV vector competence in Culex tarsalis
    Jason Rasgon; Fiscal Year: 2007
    ..This work also has important relevance for bioterrorism issues because it will provide insight into how intrinsic vector genetic factors in mosquito populations affect the epidemiology of a released Category B agent. ..
  58. Genetic basis of WNV vector competence in Culex tarsalis
    Jason L Rasgon; Fiscal Year: 2010
    ..This work also has important relevance for bioterrorism issues because it will provide insight into how intrinsic vector genetic factors in mosquito populations affect the epidemiology of a released Category B agent. ..
  59. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2008
    ..Rickettsia - like Wolbachia bacteria are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the ..
  60. Genetic basis of WNV vector competence in Culex tarsalis
    Jason Rasgon; Fiscal Year: 2008
    ..This work also has important relevance for bioterrorism issues because it will provide insight into how intrinsic vector genetic factors in mosquito populations affect the epidemiology of a released Category B agent. ..
  61. Genetic basis of WNV vector competence in Culex tarsalis
    Jason Rasgon; Fiscal Year: 2009
    ..This work also has important relevance for bioterrorism issues because it will provide insight into how intrinsic vector genetic factors in mosquito populations affect the epidemiology of a released Category B agent. ..
  62. Wolbachia as an Agent for Population Replacement in Anopheles Gambiae
    Jason Rasgon; Fiscal Year: 2007
    ..b>Wolbachia are maternally inherited endosymbionts associated with cytoplasmic incompatibility (CI) i.e...
  63. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 1993
    ..These studies will contribute to an increased understanding of the genetics and physiology of the mosquito, a disease vector with considerable impact on human health and productivity...
  64. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2000
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  65. SYNTHGESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 1992
    ..These studies will contribute to an increased understanding of the genetics and physiology of the mosquito, a disease vector with considerable impact on human health and productivity...
  66. ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATION
    Ann Fallon; Fiscal Year: 1999
    ..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors. ..
  67. ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATION
    Ann Fallon; Fiscal Year: 2000
    ..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors. ..
  68. SYNTHGESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 1991
    ..These studies will contribute to an increased understanding of the genetics and physiology of the mosquito, a disease vector with considerable impact on human health and productivity...
  69. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2001
    ..These studies provide cloned genes, molecular approaches, and characterization of regulatory processes that can potentially be manipulated to interfere with disease transmission by blood-feeding arthropods. ..
  70. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2001
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  71. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 1999
    ..These studies will contribute new information and analytical approaches to investigate gene expression and provide molecular infrastructure essential to disruption of disease transmission in genetically transformed mosquitoes. ..
  72. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2000
    ..These studies provide cloned genes, molecular approaches, and characterization of regulatory processes that can potentially be manipulated to interfere with disease transmission by blood-feeding arthropods. ..
  73. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2004
    ..These studies provide cloned genes, molecular approaches, and characterization of regulatory processes that can potentially be manipulated to interfere with disease transmission by blood-feeding arthropods. ..
  74. Optimizing Wolbachia manipulation in mosquito cell lines
    Ann Fallon; Fiscal Year: 2009
    Optimizing Wolbachia manipulation in mosquito cell lines: This proposal focuses on Wolbachia, an obligate intracellular bacterium that is widespread in arthropods, including insects that vector diseases of humans...
  75. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2003
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  76. In vitro culture and transformation of Wolbachia from mosquitoes
    Ann Fallon; Fiscal Year: 2007
    ..The intracellular bacterium, Wolbachia pipientis, provides an attractive drive mechanism, because it favors its own transmission through a reproductive ..
  77. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2004
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  78. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2004
    ....
  79. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
    ....
  80. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2003
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  81. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2003
    ....
  82. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2000
    ..b) the influence of alleles at the Nramp and iNOS loci on murine susceptibility to B. malayi. (c). the role of cytokines controlling the induction of nitric oxide in the resistance of NOD/LtSz-scid mice to B. malayi. ..
  83. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  84. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2002
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  85. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 1999
    ..b) the influence of alleles at the Nramp and iNOS loci on murine susceptibility to B. malayi. (c). the role of cytokines controlling the induction of nitric oxide in the resistance of NOD/LtSz-scid mice to B. malayi. ..