orientia tsutsugamushi

Summary

Summary: A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.

Top Publications

  1. ncbi Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand
    P E Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:168-73. 2008
  2. pmc Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection
    Won Jong Jang
    Department of Microbiology, Kon Kuk University College of Medicine, Choongju si, Choongbuk 380 701, USA
    Clin Diagn Lab Immunol 10:394-8. 2003
  3. pmc The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes
    Nam Hyuk Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Proc Natl Acad Sci U S A 104:7981-6. 2007
  4. ncbi Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus
    C G Moron
    Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555, USA
    Mod Pathol 14:752-9. 2001
  5. ncbi Scrub typhus serologic testing with the indirect immunofluorescence method as a diagnostic gold standard: a lack of consensus leads to a lot of confusion
    Stuart D Blacksell
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 44:391-401. 2007
  6. pmc Orientia tsutsugamushi stimulates an original gene expression program in monocytes: relationship with gene expression in patients with scrub typhus
    Wiwit Tantibhedhyangkul
    Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement Unité Mixte de Recherche 6236, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    PLoS Negl Trop Dis 5:e1028. 2011
  7. pmc The Whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution
    Keisuke Nakayama
    Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki, Japan
    DNA Res 15:185-99. 2008
  8. doi Fibronectin facilitates the invasion of Orientia tsutsugamushi into host cells through interaction with a 56-kDa type-specific antigen
    Jung Hee Lee
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Infect Dis 198:250-7. 2008
  9. ncbi Chemokine and cytokine production during Orientia tsutsugamushi infection in mice
    Young Sang Koh
    Department of Microbiology, Cheju National University College of Medicine, 690 756, Jeju, South Korea
    Microb Pathog 36:51-7. 2004
  10. pmc Differential patterns of endothelial and leucocyte activation in 'typhus-like' illnesses in Laos and Thailand
    D H Paris
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Exp Immunol 153:63-7. 2008

Detail Information

Publications202 found, 100 shown here

  1. ncbi Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand
    P E Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Microbiol Infect 14:168-73. 2008
    ..confirmed scrub typhus in three Thai provinces detected the 56-kDa protein-encoding gene from Orientia tsutsugamushi in ten (5%) patients...
  2. pmc Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection
    Won Jong Jang
    Department of Microbiology, Kon Kuk University College of Medicine, Choongju si, Choongbuk 380 701, USA
    Clin Diagn Lab Immunol 10:394-8. 2003
    ..an immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) for diagnosis of recent Orientia tsutsugamushi infections in humans. The 56-kDa major outer membrane protein of O...
  3. pmc The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes
    Nam Hyuk Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Proc Natl Acad Sci U S A 104:7981-6. 2007
    Scrub typhus is caused by the obligate intracellular rickettsia Orientia tsutsugamushi (previously called Rickettsia tsutsugamushi). The bacterium is maternally inherited in trombicuid mites and transmitted to humans by feeding larvae...
  4. ncbi Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus
    C G Moron
    Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555, USA
    Mod Pathol 14:752-9. 2001
    b>Orientia tsutsugamushi is the etiologic agent of scrub typhus, a chigger-borne zoonosis that is a highly prevalent, life-threatening illness of greatest public health importance in tropical Asia and the islands of the western Pacific ..
  5. ncbi Scrub typhus serologic testing with the indirect immunofluorescence method as a diagnostic gold standard: a lack of consensus leads to a lot of confusion
    Stuart D Blacksell
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 44:391-401. 2007
    ..We suggest that the diagnosis of scrub typhus using IFA should be based on a > or =4-fold increase in the titer in paired serum samples and should only be based on a single sample titer when there is an adequate local evidence base...
  6. pmc Orientia tsutsugamushi stimulates an original gene expression program in monocytes: relationship with gene expression in patients with scrub typhus
    Wiwit Tantibhedhyangkul
    Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement Unité Mixte de Recherche 6236, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    PLoS Negl Trop Dis 5:e1028. 2011
    b>Orientia tsutsugamushi is the causal agent of scrub typhus, a public health problem in the Asia-Pacific region and a life-threatening disease. O. tsutsugamushi is an obligate intracellular bacterium that mainly infects endothelial cells...
  7. pmc The Whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution
    Keisuke Nakayama
    Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki, Japan
    DNA Res 15:185-99. 2008
    ..The causative agent is Orientia tsutsugamushi, an obligate intracellular bacterium belonging to the family Rickettsiaceae of the subdivision alpha-..
  8. doi Fibronectin facilitates the invasion of Orientia tsutsugamushi into host cells through interaction with a 56-kDa type-specific antigen
    Jung Hee Lee
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Infect Dis 198:250-7. 2008
    b>Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium. The pathogen's mechanism of cellular invasion is poorly characterized.
  9. ncbi Chemokine and cytokine production during Orientia tsutsugamushi infection in mice
    Young Sang Koh
    Department of Microbiology, Cheju National University College of Medicine, 690 756, Jeju, South Korea
    Microb Pathog 36:51-7. 2004
    b>Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus which is histopathologically characterized by inflammatory manifestations, indicating that rickettsiae induce mechanisms that amplify the ..
  10. pmc Differential patterns of endothelial and leucocyte activation in 'typhus-like' illnesses in Laos and Thailand
    D H Paris
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Exp Immunol 153:63-7. 2008
    ..The cellular tropism and pathophysiology of the causative agent, Orientia tsutsugamushi, remain poorly understood...
  11. ncbi Epidemiology of scrub typhus in eastern Taiwan, 2000-2004
    Yeong Sheng Lee
    The Sixth Branch Office, Center for Disease Control, Taipei, Taiwan
    Jpn J Infect Dis 59:235-8. 2006
    ..Only one patient with no symptoms (0.8%) was found. This paper reports the status of scrub typhus in eastern Taiwan, and suggests that a health education program could train individuals to self-recognize the disease symptoms...
  12. pmc Accuracy of rapid IgM-based immunochromatographic and immunoblot assays for diagnosis of acute scrub typhus and murine typhus infections in Laos
    Stuart D Blacksell
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos
    Am J Trop Med Hyg 83:365-9. 2010
    ..for the ST ICT determined by using the diagnostic criteria of a four-fold increase in IgM against Orientia tsutsugamushi between paired samples were 23.8% (95% confidence interval [CI] = 15.9-33.3%) and 86.2% (95% CI = 84.1-88...
  13. ncbi Clinical and histological features of inoculation site skin lesions in cynomolgus monkeys experimentally infected with Orientia tsutsugamushi
    Douglas S Walsh
    Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    Vector Borne Zoonotic Dis 7:547-54. 2007
    Cynomolgus monkeys, as animal models of scrub typhus, are typically infected with Orientia tsutsugamushi by intradermal inoculation. However, the clinical and histological features at the O...
  14. doi Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway
    Kyung Ah Cho
    Department of Microbiology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
    Microb Pathog 49:95-104. 2010
    b>Orientia tsutsugamushi (OT), the causative agent of scrub typhus, is an obligate intracellular bacterium...
  15. pmc Scrub typhus vaccine candidate Kp r56 induces humoral and cellular immune responses in cynomolgus monkeys
    Suchismita Chattopadhyay
    Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Infect Immun 73:5039-47. 2005
    A truncated recombinant 56-kDa outer membrane protein of the Karp strain of Orientia tsutsugamushi (Kp r56) was evaluated in cynomolgus monkeys (Macaca fascicularis) for immunogenicity and safety as a vaccine candidate for the prevention ..
  16. ncbi Development of a quantitative real-time polymerase chain reaction assay specific for Orientia tsutsugamushi
    Ju Jiang
    Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Trop Med Hyg 70:351-6. 2004
    Two specific and sensitive polymerase chain reaction (PCR) assays were developed to detect and quantitate Orientia tsutsugamushi, the agent of scrub typhus, using a portion of the 47-kD outer membrane protein antigen/ high temperature ..
  17. pmc Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients
    Stefanie Kramme
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Clin Microbiol 47:586-9. 2009
    Scrub typhus, caused by the intracellular bacterium Orientia tsutsugamushi, is a major cause of febrile illness in the Asia/Pacific region...
  18. pmc Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus Infection
    Stuart D Blacksell
    Mahidol University Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Clin Vaccine Immunol 17:263-6. 2010
    ..we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in ..
  19. pmc Clinical and laboratory findings associated with severe scrub typhus
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University School of Medicine, Gwangju City, Republic of Korea
    BMC Infect Dis 10:108. 2010
    Scrub typhus is a mite-borne bacterial infection of humans caused by Orientia tsutsugamushi that causes a generalized vasculitis that may involve the tissues of any organ system...
  20. pmc Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 6:e1466. 2012
    ..typhus is a common and underdiagnosed cause of febrile illness in Southeast Asia, caused by infection with Orientia tsutsugamushi. Inoculation of the organism at a cutaneous mite bite site commonly results in formation of a localized ..
  21. ncbi Antibodies to Orientia tsutsugamushi, Rickettsia typhi and spotted fever group rickettsiae among febrile patients in rural areas of Malaysia
    S T Tay
    Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia
    Trans R Soc Trop Med Hyg 94:280-4. 2000
    ..conducted in 1995-97 among 1596 febrile patients from 8 health centres in Malaysia for antibodies against Orientia tsutsugamushi (OT), Rickettsia typhi (RT) and TT118 spotted fever group rickettsiae (SFGR) by using an indirect ..
  22. pmc A highly sensitive quantitative real-time PCR assay based on the groEL gene of contemporary Thai strains of Orientia tsutsugamushi
    D H Paris
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Microbiol Infect 15:488-95. 2009
    ..bp) of the groEL gene (encoding the 60-kDa heat shock protein, HSP60) from 23 contemporary isolates of Orientia tsutsugamushi isolated from patients with acute scrub typhus in Thailand were compared with 16 reference strain ..
  23. pmc Differences in clinical features according to Boryoung and Karp genotypes of Orientia tsutsugamushi
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea
    PLoS ONE 6:e22731. 2011
    Scrub typhus is an infectious disease caused by Orientia tsutsugamushi. The differences in virulence of O. tsutsugamushi prototypes in humans are still unknown...
  24. ncbi Scrub typhus and tropical rickettsioses
    George Watt
    Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Curr Opin Infect Dis 16:429-36. 2003
    ..The agent responsible for scrub typhus (Orientia tsutsugamushi ) has been removed from the genus Rickettsia and a bewildering array of new rickettsial pathogens have ..
  25. pmc Intracellular invasion by Orientia tsutsugamushi is mediated by integrin signaling and actin cytoskeleton rearrangements
    Bon A Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Jongno gu, 28 Yongond Dong, Jongno gu, Seoul 110 799, Republic of Korea
    Infect Immun 78:1915-23. 2010
    b>Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular pathogen. Previously, we reported that the 56-kDa type-specific antigen (TSA56), a major outer membrane protein of O...
  26. ncbi Outbreak of scrub typhus in southern India during the cooler months
    E Mathai
    Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India
    Ann N Y Acad Sci 990:359-64. 2003
    b>Orientia tsutsugamushi, the agent of scrub typhus, is a strict intracellular bacterium which is found in many parts of Asia including India...
  27. pmc Association of high Orientia tsutsugamushi DNA loads with disease of greater severity in adults with scrub typhus
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 47:430-4. 2009
    b>Orientia tsutsugamushi, the cause of scrub typhus, is a major pathogen in the Asia-Pacific region. The severity of infection ranges from mild features to multiorgan failure and death. The aim of this prospective study was to define the O...
  28. doi Variable clinical responses of a scrub typhus outbred mouse model to feeding by Orientia tsutsugamushi infected mites
    Woradee Lurchachaiwong
    Department of Entomology, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Exp Appl Acarol 58:23-34. 2012
    Rodents are the natural hosts for Leptotrombidium mites that transmit Orientia tsutsugamushi, the causative agent of scrub typhus, a potentially fatal febrile human disease. Utilizing mite lines that included O...
  29. pmc Infectious etiologies of acute febrile illness among patients seeking health care in south-central Cambodia
    Matthew R Kasper
    United States Naval Medical Research Unit 2, Jakarta, Indonesia
    Am J Trop Med Hyg 86:246-53. 2012
    ..Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations...
  30. pmc High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen Orientia tsutsugamushi
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e752. 2010
    b>Orientia tsutsugamushi is an intracellular alpha-proteobacterium which resides in trombiculid mites, and is the causative agent of scrub typhus in East Asia...
  31. pmc Role of macrophages in innate and acquired host resistance to experimental scrub typhus infection of inbred mice
    T R Jerrells
    Infect Immun 37:1066-73. 1982
    ..Resistance of C3H/RV mice to intraperitoneal infection, in contrast, apparently was dependent only on an irradiation-sensitive process...
  32. pmc Scrub typhus in previously unrecognized areas of endemicity in China
    Shouyin Zhang
    State Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, China Centers for Disease Control and Prevention, Beijing 102206, China
    J Clin Microbiol 48:1241-4. 2010
    Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist...
  33. pmc Antigenic drift of Orientia tsutsugamushi in South Korea as identified by the sequence analysis of a 56-kDa protein-encoding gene
    Sang Won Park
    Department of Internal Medicine, Seoul National University College of Medicine and Boramae Medical Center, Seoul, Republic of Korea
    Am J Trop Med Hyg 83:930-5. 2010
    This study was performed to determine the nationwide antigenic diversity of Orientia tsutsugamushi in South Korea. Sequence analysis was performed around variable domains I and II of a 56-kDa protein-encoding gene...
  34. pmc Diagnostic accuracy of a loop-mediated isothermal PCR assay for detection of Orientia tsutsugamushi during acute Scrub Typhus infection
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 5:e1307. 2011
    ..There is an urgent need to develop rapid and accurate point-of-care (POC) technologies for acute scrub typhus diagnosis in low-resource, primary health care settings to guide clinical therapy...
  35. ncbi Protection against scrub typhus by a plasmid vaccine encoding the 56-KD outer membrane protein antigen gene
    Yi sheng Ni
    Rickettsial Diseases Department, U S Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Am J Trop Med Hyg 73:936-41. 2005
    The 56-kD outer membrane protein of Orientia tsutsugamushi has previously been shown to be the immunodominant antigen in scrub typhus infections. Its gene was cloned into the DNA vaccine vector pVR1012 as a vaccine candidate (pKarp56)...
  36. ncbi Serological evidence for the continued presence of human rickettsioses in southern India
    E Mathai
    Department of Clinical Microbiology, Christian Medical College Hospital, Vellore, Tamil Nadu 632004, India
    Ann Trop Med Parasitol 95:395-8. 2001
    ..The epidemiology and magnitude of the problem need to be evaluated...
  37. ncbi Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection
    Ji Hyun Yun
    Department of Microbiology, Cheju National University College of Medicine, Jeju, Republic of Korea
    Microbiol Immunol 49:551-7. 2005
    ..These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection...
  38. pmc An autotransporter protein from Orientia tsutsugamushi mediates adherence to nonphagocytic host cells
    Na Young Ha
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Jongno gu, Seoul 110 799, Republic of Korea
    Infect Immun 79:1718-27. 2011
    b>Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular pathogen whose mechanism of cellular adhesion and invasion is poorly characterized. Bioinformatic analyses of two O...
  39. ncbi Laboratory diagnosis of two scrub typhus outbreaks at Camp Fuji, Japan in 2000 and 2001 by enzyme-linked immunosorbent assay, rapid flow assay, and Western blot assay using outer membrane 56-kD recombinant proteins
    Ju Jiang
    Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Trop Med Hyg 69:60-6. 2003
    ..immunosorbent assay (ELISA), rapid flow assay (RFA), and Western blot assay for evidence of infection with Orientia tsutsugamushi, the causative agent of scrub typhus...
  40. pmc Genotype diversity and distribution of Orientia tsutsugamushi causing scrub typhus in Thailand
    Toon Ruang-areerate
    Research Division, Armed Forces Research Institute of Medical Science, Bangkok 10400, Thailand
    J Clin Microbiol 49:2584-9. 2011
    Scrub typhus, caused by antigenically disparate isolates of Orientia tsutsugamushi, is a widely distributed mite-borne human disease in the Asia Pacific region...
  41. pmc High-level expression of a 56-kilodalton protein gene (bor56) of Rickettsia tsutsugamushi Boryong and its application to enzyme-linked immunosorbent assays
    I S Kim
    Department of Microbiology, Seoul National University College of Medicine, Republic of Korea
    J Clin Microbiol 31:598-605. 1993
    ....
  42. ncbi Scrub typhus: an unrecognized threat in South India - clinical profile and predictors of mortality
    Anugrah Chrispal
    Department of Medicine Unit 2, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Trop Doct 40:129-33. 2010
    ....
  43. ncbi Scrub typhus vaccines: past history and recent developments
    Suchismita Chattopadhyay
    Rickettsial Diseases Research Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Hum Vaccin 3:73-80. 2007
    ..febrile and potentially fatal disease, caused by infection with the obligate intracellular bacterium Orientia tsutsugamushi, is commonly seen in the Asia-Pacific region...
  44. pmc Kinetics and magnitude of antibody responses against the conserved 47-kilodalton antigen and the variable 56-kilodalton antigen in scrub typhus patients
    Hua Wei Chen
    Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Clin Vaccine Immunol 18:1021-7. 2011
    Western blot analysis of Orientia tsutsugamushi whole-cell lysates with scrub typhus patient sera has identified at least five protein antigens of O. tsutsugamushi with molecular sizes of 22 kDa, 47 kDa, 56 kDa, 58 kDa, and 110 kDa...
  45. pmc Expression and refolding of truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi and its use in enzyme-linked immunosorbent assays
    W M Ching
    Viral and Rickettsial Diseases Program, Infectious Diseases Department, Naval Medical Research Institute, Bethesda, Maryland 20889 5607, USA
    Clin Diagn Lab Immunol 5:519-26. 1998
    The variable 56-kDa major outer membrane protein of Orientia tsutsugamushi is the immunodominant antigen in human scrub typhus infections. The gene encoding this protein from Karp strain was cloned into the expression vector pET11a...
  46. doi Simple, rapid and sensitive detection of Orientia tsutsugamushi by loop-isothermal DNA amplification
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Programme, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithee Road, 10400 Bangkok, Thailand
    Trans R Soc Trop Med Hyg 102:1239-46. 2008
    ..isothermal PCR assay (LAMP) targeting the groEL gene, which encodes the 60kDa heat shock protein of Orientia tsutsugamushi. Evaluation included testing of 63 samples of contemporary in vitro isolates, buffy coats and whole blood ..
  47. ncbi Orientia tsutsugamushi in peripheral white blood cells of patients with acute scrub typhus
    D S Walsh
    Department of Immunology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 65:899-901. 2001
    Scrub typhus, caused by Orientia tsutsugamushi, is an acute illness that occurs in many parts of Asia. Clinical manifestations range from inapparent to organ failure...
  48. pmc Expression of chemokine genes in human dermal microvascular endothelial cell lines infected with Orientia tsutsugamushi
    N H Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 110-799, Republic of Korea
    Infect Immun 69:1265-72. 2001
    Scrub typhus, caused by Orientia tsutsugamushi, is characterized by local as well as systemic inflammatory manifestations...
  49. doi Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi
    Daryl J Kelly
    Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA
    Clin Infect Dis 48:S203-30. 2009
    b>Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region...
  50. pmc Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release
    Mee Kyung Kim
    Department of Microbiology, Inha University College of Medicine, Inchon 400 103, Republic of Korea
    Infect Immun 70:4692-6. 2002
    b>Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection...
  51. doi Correlation between the concentrations of tumor necrosis factor-alpha and the severity of disease in patients infected with Orientia tsutsugamushi
    Hiromichi Iwasaki
    First Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Matsuoka, Fukui, Japan
    Int J Infect Dis 14:e328-33. 2010
    ....
  52. ncbi Determination and geographic distribution of Orientia tsutsugamushi serotypes in Thailand by nested polymerase chain reaction
    Jiradej Manosroi
    Pharmaceutical Cosmetic Raw Materials and Natural Products Research and Development Center PCRNC, Institute for Science and Technology Research and Development Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
    Diagn Microbiol Infect Dis 55:185-90. 2006
    ..The serotypes of Orientia tsutsugamushi and their geographic distribution were determined...
  53. ncbi Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis
    Wirongrong Chierakul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Immunol 113:140-4. 2004
    ..cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans...
  54. pmc Genome comparison and phylogenetic analysis of Orientia tsutsugamushi strains
    Keisuke Nakayama
    Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Miyazaki 899 1692, Japan
    DNA Res 17:281-91. 2010
    b>Orientia tsutsugamushi (OT) is an obligate intracellular bacterium belonging to the family Rickettsiaceae and is the causative agent of scrub typhus, or Tsutsugamushi disease...
  55. pmc Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes
    Hyuk Chu
    Department of Microbiology and Immunology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Infect Immun 74:4246-53. 2006
    b>Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium that requires the exploitation of the endocytic pathway in the host cell. We observed the localization of O...
  56. ncbi The past and present threat of rickettsial diseases to military medicine and international public health
    Daryl J Kelly
    Department of Molecular Genetics, Ohio State University, Columbus, OH, USA
    Clin Infect Dis 34:S145-69. 2002
    ..With their uneven worldwide distribution, the discovery of drug-refractory strains of Orientia tsutsugamushi, the increased threat of their use in acts of bioterrorism, frequent deployment of troops to regions of ..
  57. pmc Host defenses in experimental scrub typhus: genetics of natural resistance to infection
    M G Groves
    Infect Immun 19:583-8. 1978
    ..tsutsugamushi...
  58. ncbi Real-time multiplex PCR assay for detection and differentiation of rickettsiae and orientiae
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 102:186-93. 2008
    ..Asia necessitates rapid and accurate diagnostic tools for a broad range of rickettsial agents, including Orientia tsutsugamushi (scrub typhus) and Rickettsia typhi (murine typhus), but also spotted fever group infections, which are ..
  59. ncbi Comparative evaluation of selected diagnostic assays for the detection of IgG and IgM antibody to Orientia tsutsugamushi in Thailand
    Russell E Coleman
    Department of Entomology, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 67:497-503. 2002
    ..One of the ELISAs used pooled cell lysates of Karp, Kato, and Gilliam strain Orientia tsutsugamushi as antigen (pooled-antigen ELISA), and the other used a recombinant r56 protein as the antigen (..
  60. ncbi Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis
    George Watt
    Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:89-91. 2003
    Possible coinfections with Orientia tsutsugamushi the causative agent of scrub typhus, were prospectively evaluated in rice farmers hospitalized with leptospirosis in Northeast Thailand...
  61. pmc Acute renal failure due to acute tubular necrosis caused by direct invasion of Orientia tsutsugamushi
    Dong Min Kim
    Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk dong, Dong Gu, Gwangju 501 717, South Korea
    J Clin Microbiol 46:1548-50. 2008
    ..For our case, we demonstrated by IHC staining and EM that renal failure was caused by acute tubular necrosis due to a direct invasion of Orientia tsutsugamushi.
  62. pmc Analysis of the cross-reactivity of various 56 kDa recombinant protein antigens with serum samples collected after Orientia tsutsugamushi infection by ELISA
    Chien Chung Chao
    Viral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Am J Trop Med Hyg 84:967-72. 2011
    b>Orientia tsutsugamushi, the etiologic agent of scrub typhus, has a highly expressed and immunodominant 56-kD outer membrane protein. This protein is one of the leading candidates for diagnosis and vaccine development for scrub typhus...
  63. doi Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment
    R Premaratna
    Department of Medicine, Faculty of Medicine, University of Kelaniya PO Box 6, Thalagolla Road, Ragama, Sri Lanka ranjan
    Trans R Soc Trop Med Hyg 104:368-70. 2010
    ..Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10 (36%) as having Orientia tsutsugamushi. Seven were negative for all tests...
  64. pmc Detection of antibodies against Orientia tsutsugamushi Sca proteins in scrub typhus patients and genetic variation of sca genes of different strains
    Na Young Ha
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Vaccine Immunol 19:1442-51. 2012
    Scrub typhus, caused by Orientia tsutsugamushi infection, is one of the main causes of acute febrile illness in the Asian-Pacific region...
  65. doi Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Republic of Korea
    Diagn Microbiol Infect Dis 69:271-4. 2011
    ..Clinicians should be alerted to the possibility that meningoencephalitis can occur because of inadequate maintenance of serum doxycycline level caused by antacids administered along with doxycycline...
  66. pmc Scrub typhus reemergence in the Maldives
    Michael D Lewis
    Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Emerg Infect Dis 9:1638-41. 2003
    ..The Armed Forces Research Institute of Medical Sciences in Bangkok confirmed Orientia tsutsugamushi and conducted a joint investigation with the Ministry of Health, Maldives...
  67. ncbi Comparison of immune response against Orientia tsutsugamushi, a causative agent of scrub typhus, in 4-week-old and 10-week-old scrub typhus-infected laboratory mice using enzyme-linked immunosorbent assay technique
    Kriangkrai Lerdthusnee
    Department of Entomology, USAMC AFRIMS, 315 6 Rajvithi Road, Phya Thai, Bangkok 10400, Thailand
    Ann N Y Acad Sci 1078:607-12. 2006
    ..Considering the earlier detection and slightly higher level of specific IgM antibody, it could be interpreted that the older mice may appear to have responded against O. tsutsugamushi faster than the younger mice...
  68. pmc Endemic scrub typhus-like illness, Chile
    M Elvira Balcells
    School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Emerg Infect Dis 17:1659-63. 2011
    ..A molecular sample, identified as related to Orientia tsutsugamushi based on the sequence of the16S rRNA gene, was obtained from a biopsy specimen of the eschar on the ..
  69. ncbi Long-term egg-yolk adaptation of the Orientia tsutsugamushi for preparation of a formalinized immunogen
    Y Choi
    Graduate School of Life Sciences and Biotechnology, Korea University, Anamdong 5 1, Sungbuk Ku, Seoul 136 701, South Korea Therapia Gene Co, 341 Pojung Ri, Koosung myon, Yongin, 449 910, Korea
    Vaccine 24:1438-45. 2006
    ..of preparing a killed rickettsial vaccine against the scrub typhus, the Karp and Gilliam strains of the Orientia tsutsugamushi were adapted through sequential passages in eggs for more than 100 times over 9 years to produce ..
  70. ncbi Determination and geographical distribution of Orientia tsutsugamushi serotypes in Korea by nested polymerase chain reaction
    H I Ree
    Institute of Tropical Medicine, College of Medicine, Yonsei University, Seoul, Korea
    Am J Trop Med Hyg 65:528-34. 2001
    ..were collected at 30 locations in Korea in October and November 1997-1999 to determine the serotypes of Orientia tsutsugamushi and their geographical distribution...
  71. pmc Phylogenetic analysis of the 56-kDa type-specific protein genes of Orientia tsutsugamushi in Central Korea
    Hye Won Jeong
    Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
    J Korean Med Sci 27:1315-9. 2012
    There are several antigenic variants of Orientia tsutsugamushi. The 56-kDa type-specific antigen (TSA) is responsible for the antigenic variation...
  72. ncbi Characterization of Orientia tsutsugamushi isolated in Taiwan by immunofluorescence and restriction fragment length polymorphism analyses
    A Tamura
    Department of Microbiology, Niigata College of Pharmacy, Japan
    FEMS Microbiol Lett 150:225-31. 1997
    A total of 10 strains of Orientia tsutsugamushi were isolated from field rodents and chiggers in Taiwan, and characterized by immunofluorescence analysis with monoclonal antibodies and by restriction fragment length polymorphism analysis ..
  73. pmc Effects of antibiotic treatment on the results of nested PCRs for scrub typhus
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk dong, Dong Gu, Gwangju 501 717, Republic of Korea
    J Clin Microbiol 46:3465-6. 2008
    ..Since the sensitivity of nested PCR can be affected by antibiotic administration, clinicians should perform this PCR before antibiotic administration and at the latest within 3 days after antibiotic administration...
  74. doi Subversion of host cell signaling by Orientia tsutsugamushi
    Yan Ge
    Department of Immunology and Pathogen Biology, Tongji University School of Medicine, Shanghai 200092, China
    Microbes Infect 13:638-48. 2011
    Progress has been made in deciphering the mechanisms on Orientia tsutsugamushi-host interaction. The genome sequencing, microarray and proteomic analyses of this ancient bacterium have provided a wealth of new information...
  75. ncbi Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan
    I Nagano
    Department of Parasitology, Gifu University School of Medicine, Japan
    Microbiol Immunol 40:743-7. 1996
    Four strains of Orientia tsutsugamushi (KN-1, KN-2, KN-3 and GJ-1) isolated from patients in an area of Gifu Prefecture, Japan, in which tsutsugamushi disease is newly endemic, were examined for their virulence in mice...
  76. ncbi Distribution of eschars on the body of scrub typhus patients: a prospective study
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea
    Am J Trop Med Hyg 76:806-9. 2007
    ..7% (44 patients) of all the detected eschars. Our study is the first report of a schematic diagram that shows the differences between the males and females with respect to eschar location in scrub typhus patients...
  77. ncbi Survival of two Orientia tsutsugamushi bacterial strains that infect mouse macrophages with varying degrees of virulence
    Masahiro Fukuhara
    Laboratory of Microbiology, Faculty of Pharmacy, Niigata University of Pharmacy and Applied Life Sciences NUPALS, 265 1 Higashijima, Niigata 956 8603, Japan
    Microb Pathog 39:177-87. 2005
    b>Orientia tsutsugamushi, an intracellular parasitic bacterium, comprises numerous strains of differing virulence...
  78. doi Global gene expression profile of Orientia tsutsugamushi
    Bon A Cho
    Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
    Proteomics 10:1699-715. 2010
    b>Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of Scrub typhus. The control mechanisms for bacterial gene expression are largely unknown. Here, the global gene expression of O...
  79. doi Novel polysaccharide antigen of Orientia tsutsugamushi revealed by a monoclonal antibody
    Sun Myoung Lee
    Department of Microbiology and Center for Advanced Medical Education by BK21 Project, Inha University School of Medicine, Incheon, Korea
    FEMS Microbiol Lett 297:95-100. 2009
    b>Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium that replicates in the cytosol of host cells...
  80. ncbi Electron microscopic observations of Orientia tsutsugamushi in salivary gland cells of naturally Infected Leptotrombidium pallidum larvae during feeding
    Teruki Kadosaka
    Department of Parasitology, Aichi Medical University School of Medicine, Aichi 480 1195, Japan
    Microbiol Immunol 47:727-33. 2003
    We performed a detailed electron microscopic observation on the escaping process of Orientia tsutsugamushi from the salivary gland cells of naturally infected trombiculid larvae into the acinar lumen of the gland during feeding on mice...
  81. pmc Induction of the gene encoding macrophage chemoattractant protein 1 by Orientia tsutsugamushi in human endothelial cells involves activation of transcription factor activator protein 1
    Nam Hyuk Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine, and Institute of Endemic Disease, Seoul National University Medical Research Center, Chongno Gu, Seoul 110 799, Republic of Korea
    Infect Immun 70:4841-50. 2002
    ..b>Orientia tsutsugamushi causes vasculitis in humans by replicating inside macrophages and endothelial cells...
  82. doi Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi
    Wiwit Tantibhedhyangkul
    URMITE CNRS IRD UMR 6236, Faculte de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Antimicrob Agents 35:338-41. 2010
    ..To clarify this matter, we determined the in vitro susceptibility of Orientia tsutsugamushi strain Kato to ciprofloxacin and ofloxacin and sequenced the quinolone resistance-determining region (QRDR)..
  83. doi Inhibition of Orientia tsutsugamushi infection by a truncated recombinant 56-kDa outer membrane protein
    S Park
    Division of Zoonoses, Center for Immunology and Pathology, National Institute of Health, Seoul, Korea
    Lett Appl Microbiol 50:445-51. 2010
    The objective of this study was to evaluate recombinant 56-kDa outer membrane protein as a potential inhibitor to infection from Orientia tsutsugamushi.
  84. doi Phylogenetic clustering of 4 prevalent virulence genes in Orientia tsutsugamushi isolates from human patients
    Hyuk Chu
    Division of Zoonoses, Center for Immunology and Pathology, National Institute of Health, Seoul, Republic of Korea
    J Microbiol 48:124-8. 2010
    ..The relationships between these virulence genes and strains are not clear in Orientia tsutsugamushi yet. In this study, we confirmed the presence of the virulence genes and classified into O...
  85. pmc Rickettsial infections and fever, Vientiane, Laos
    Simaly Phongmany
    Mahosot Hospital, Vientiane, Laos
    Emerg Infect Dis 12:256-62. 2006
    ..The organisms identified by serologic analysis were Orientia tsutsugamushi (14.8%), Rickettsia typhi (9.6%), and spotted fever group rickettsia (2.6% [8 R. helvetica, 1 R...
  86. ncbi Epidemiologic, clinical and laboratory features of scrub typhus in thirty Thai children
    Virat Sirisanthana
    Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Pediatr Infect Dis J 22:341-5. 2003
    ..Although serologic surveys suggested that as many as one-fourth of cases of scrub typhus might be in children, very few reports of childhood scrub typhus are available in the medical literature...
  87. ncbi Orientia tsutsugamushi infection: overview and immune responses
    S Y Seong
    Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Disease, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, 110-799, Seoul, South Korea
    Microbes Infect 3:11-21. 2001
    b>Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930...
  88. ncbi Risk-factors for human infection with Orientia tsutsugamushi: a case-control study in Korea
    D M Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea
    Clin Microbiol Infect 14:174-7. 2008
    ..45; 95% CI 0.24-0.83). These results suggest that a health education programme will lower the risk of developing scrub typhus when applied to high-risk groups...
  89. ncbi Vertical transmission of Orientia tsutsugamushi in two lines of naturally infected Leptotrombidium deliense (Acari: Trombiculidae)
    S P Frances
    Department of Entomology, U.S. Army Component, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400, Thailand
    J Med Entomol 38:17-21. 2001
    Vertical transmission of Orientia tsutsugamushi (Hayashi), the etiologic agent for scrub typhus, was studied in two lines of naturally infected Leptotrombidium deliense Walch...
  90. ncbi Characterization of monoclonal antibody reacting exclusively against intracellular Orientia tsutsugamushi
    Mee Kyung Kim
    Department of Microbiology, Inha University College of Medicine, Inchon 400 103, Republic of Korea
    Microbiol Immunol 46:733-40. 2002
    ..Here we describe a monoclonal antibody (MAb) that reacts exclusively against intracellular Orientia tsutsugamushi. Although MAb applied to the 56-kDa protein, a major outer membrane protein, reacted against a large ..
  91. pmc Use of chimeric antibodies as positive controls in an enzyme-linked immunosorbent assay for diagnosis of scrub typhus (infection by Orientia tsutsugamushi)
    Martina L Jones
    School of Molecular and Microbial Sciences, University of Queensland, St Lucia 4072, QLD, Australia
    Clin Vaccine Immunol 14:1307-10. 2007
    ..We have investigated the potential use of chimeric IgG with specificity for the major surface antigen of Orientia tsutsugamushi as an alternative positive control for inclusion in a commercial enzyme-linked immunosorbent assay kit for ..
  92. ncbi Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China
    Li Juan Zhang
    Department of Rickettsiology, National Institute of Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    Chin Med J (Engl) 120:1314-8. 2007
    ..Diagnosis of scrub typhus was made by local clinicians. In order to ascertain the disease, we undertook a laboratory investigation for such patients from August 18 to 26, 2005...
  93. pmc Recombinant 56-kilodalton major outer membrane protein antigen of Orientia tsutsugamushi Shanxi and its antigenicity
    Wei Jun Chen
    Institute of Microbiology and Epidemiology, Beijing 100071, China
    Infect Immun 71:4772-9. 2003
    The gene encoding the 56-kDa protein of Orientia tsutsugamushi Shanxi was amplified by a nested PCR and cloned into the expression vector pQE30. The 56-kDa protein of O...
  94. ncbi Rapid diagnosis of scrub typhus in rural Thailand using polymerase chain reaction
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 75:1099-102. 2006
    ..PCR using primers to amplify a fragment of the 56-kd gene had a sensitivity and specificity of 29.0% and 99.2%, respectively. PCR has a high specificity but low sensitivity for the rapid diagnosis of scrub typhus in this endemic setting...
  95. pmc Orientia tsutsugamushi in eschars from scrub typhus patients
    Yun Xi Liu
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Emerg Infect Dis 12:1109-12. 2006
    To verify the value of eschars for the diagnosis of scrub typhus and to characterize genotypes of Orientia tsutsugamushi in patients, we examined eschars and blood specimens of 7 patients from Shandong Province, People's Republic of China,..
  96. ncbi The genomic and metabolic diversity of Rickettsia
    Hans Henrik Fuxelius
    Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvagen 18C, S 752 36 Uppsala, Sweden
    Res Microbiol 158:745-53. 2007
    ..These contradictory evolutionary forces highlight the influence of chance, adaptation and host-cell exploitation during the evolution of intracellular bacteria...
  97. pmc Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi
    W M Ching
    Viral and Ricksettial Diseases Department, Infectious Diseases Directorate, Code 41, Naval Medical Research Center, Bethesda, Maryland, USA
    Clin Diagn Lab Immunol 8:409-14. 2001
    The variable 56-kDa major outer membrane protein of Orientia tsutsugamushi is the immunodominant antigen in human scrub typhus infections...
  98. ncbi Characterization of Orientia tsutsugamushi strains isolated in Shandong Province, China by immunofluorescence and restriction fragment length polymorphism (RFLP) analyses
    Yun Xi Liu
    School of Public Health, Shandong University, Jinan, PR China
    Southeast Asian J Trop Med Public Health 35:353-7. 2004
    ..In Shandong Province, the gene types of epidemic O. tsutsugamushi strains were similar to the Japan Kawasaki type, but had some differences in gene sequence. In addition, Karp also existed...
  99. ncbi Transmission of Orientia tsutsugamushi, the aetiological agent for scrub typhus, to co-feeding mites
    S P Frances
    Department of Medical Entomology, Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand
    Parasitology 120:601-7. 2000
    Experiments were conducted to investigate the potential for transmission of Orientia tsutsugamushi, the aetiological agent for scrub typhus, when naturally infected mite larvae were co-feeding with uninfected larvae...
  100. ncbi Induction of protective immunity against scrub typhus with a 56-kilodalton recombinant antigen fused with a 47-kilodalton antigen of Orientia tsutsugamushi Karp
    Yuefei Yu
    Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing, People s Republic of China
    Am J Trop Med Hyg 72:458-64. 2005
    ..gene sequence encoding the 56-kD scrub typhus antigen (Sta56) was amplified from genomic DNA of the Orientia tsutsugamushi Karp strain by a polymerase chain reaction (PCR)...
  101. ncbi Short report: detection of Orientia tsutsugamushi in clinical samples by quantitative real-time polymerase chain reaction
    Tasawan Singhsilarak
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 72:640-1. 2005
    b>Orientia tsutsugamushi infection causes scrub typhus, a common zoonosis of rural Asia. Orientia tsutsugamushi was recently detected by a real-time quantitative polymerase chain reaction (qPCR) assay in animal specimens...

Research Grants13

  1. Role of the endothelium in the T cell-mediated anti-rickettsial immune response
    Gustavo Valbuena; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2012
    ..Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, Toxoplasma gondii, M. tuberculosis, variola major related pox viruses, Dengue, and West Nile)...
  3. Genetic Mechanisms Driving Evolution of Rickettsiaceae
    Anup Madan; Fiscal Year: 2006
    ..b>Orientia tsutsugamushi, Rickettsia akari, R. canada, and R. bellii will be studied...
  4. Genetic Mechanisms Driving Evolution of Rickettsiaceae
    Anup Madan; Fiscal Year: 2005
    ..b>Orientia tsutsugamushi, Rickettsia akari, R. canada, and R. bellii will be studied...
  5. Genetic Mechanisms Driving Evolution of Rickettsiaceae
    Anup Madan; Fiscal Year: 2003
    ..b>Orientia tsutsugamushi, Rickettsia akari, R. canada, and R. bellii will be studied...
  6. Genetic Mechanisms Driving Evolution of Rickettsiaceae
    Anup Madan; Fiscal Year: 2003
    ..b>Orientia tsutsugamushi, Rickettsia akari, R. canada, and R. bellii will be studied...
  7. Genetic Mechanisms Driving Evolution of Rickettsiaceae
    Anup Madan; Fiscal Year: 2004
    ..b>Orientia tsutsugamushi, Rickettsia akari, R. canada, and R. bellii will be studied...
  8. Role of the endothelium in the T cell-mediated anti-rickettsial immune response
    Gustavo Valbuena; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Modulation of Lung Innate Immunity by Prostaglandin E2
    David Aronoff; Fiscal Year: 2008
    ..Successful completion of the studies outlined in the proposal will help to define a relatively understudied component of host defense and may lead to the development of better preventive and therapeutic strategies against pneumonia. ..
  10. Modulation of Lung Innate Immunity by Prostaglandin E2
    David Aronoff; Fiscal Year: 2007
    ..Successful completion of the studies outlined in the proposal will help to define a relatively understudied component of host defense and may lead to the development of better preventive and therapeutic strategies against pneumonia. ..
  11. Role of misoprostol in Clostridium sordellii endometritis after medical abortion
    David Aronoff; Fiscal Year: 2008
    ....
  12. Role of misoprostol in Clostridium sordellii endometritis after medical abortion
    David Aronoff; Fiscal Year: 2009
    ....
  13. Role of misoprostol in Clostridium sordellii endometritis after medical abortion
    David M Aronoff; Fiscal Year: 2010
    ....