helicobacter heilmannii

Summary

Summary: A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.

Top Publications

  1. ncbi Acute phlegmonous gastritis associated with Helicobacter heilmannii infection in a child
    Rok Orel
    Division of Paediatrics, Department of Gastroenterology, University Medical Centre Ljubljana, Pediatricna klinika, Vrazov trg 1, 1000, Ljubljana, Slovenia
    Dig Dis Sci 51:2322-5. 2006
  2. pmc Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis
    Mee Joo
    Department of Pathology, College of Medicine, Inje University Ilsanpaik Hospital, Goyang, Korea
    J Korean Med Sci 22:63-9. 2007
  3. ncbi Helicobacter heilmannii related gastric ulcer in childhood
    Josef Sykora
    Department of Paediatrics, Faculty Hospital, Charles University, Plezn, Czech Republic
    J Pediatr Gastroenterol Nutr 36:410-3. 2003
  4. ncbi Helicobacter heilmannii reinfection in a Helicobacter pylori negative adolescent: a 4-year follow-up
    Konrad Siala
    J Clin Gastroenterol 41:221-2. 2007
  5. ncbi Helicobacter heilmannii gastroduodenal disease and clinical aspects in children with dyspeptic symptoms
    J Sykora
    Department of Paediatrics, Charles University Hospital, Pilsen, Czech Republic
    Acta Paediatr 93:707-9. 2004
  6. ncbi Helicobacter heilmannii infection in a child after successful eradication of Helicobacter pylori: case report and review of literature
    Seiichi Kato
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 40:94-7. 2005
  7. pmc Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing
    K Trebesius
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    J Clin Microbiol 39:1510-6. 2001
  8. ncbi The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms
    B Iwanczak
    Department of Pediatrics, Gastroenterology and Nutrition, Medical University of Wroclaw, Wroclaw, Poland
    J Physiol Pharmacol 63:133-6. 2012
  9. ncbi Description of 'Candidatus Helicobacter heilmannii' based on DNA sequence analysis of 16S rRNA and urease genes
    Jani L O'Rourke
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia, 2052
    Int J Syst Evol Microbiol 54:2203-11. 2004
  10. pmc Evaluation of "Helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogs
    Simon L Priestnall
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14851, USA
    J Clin Microbiol 42:2144-51. 2004

Scientific Experts

Detail Information

Publications98

  1. ncbi Acute phlegmonous gastritis associated with Helicobacter heilmannii infection in a child
    Rok Orel
    Division of Paediatrics, Department of Gastroenterology, University Medical Centre Ljubljana, Pediatricna klinika, Vrazov trg 1, 1000, Ljubljana, Slovenia
    Dig Dis Sci 51:2322-5. 2006
  2. pmc Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis
    Mee Joo
    Department of Pathology, College of Medicine, Inje University Ilsanpaik Hospital, Goyang, Korea
    J Korean Med Sci 22:63-9. 2007
    The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis...
  3. ncbi Helicobacter heilmannii related gastric ulcer in childhood
    Josef Sykora
    Department of Paediatrics, Faculty Hospital, Charles University, Plezn, Czech Republic
    J Pediatr Gastroenterol Nutr 36:410-3. 2003
  4. ncbi Helicobacter heilmannii reinfection in a Helicobacter pylori negative adolescent: a 4-year follow-up
    Konrad Siala
    J Clin Gastroenterol 41:221-2. 2007
  5. ncbi Helicobacter heilmannii gastroduodenal disease and clinical aspects in children with dyspeptic symptoms
    J Sykora
    Department of Paediatrics, Charles University Hospital, Pilsen, Czech Republic
    Acta Paediatr 93:707-9. 2004
    To evaluate the occurrence and clinical characteristics of Helicobacter heilmannii infection among children presenting with dyspeptic symptoms.
  6. ncbi Helicobacter heilmannii infection in a child after successful eradication of Helicobacter pylori: case report and review of literature
    Seiichi Kato
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 40:94-7. 2005
    ..A 7-day course with lansoprazole, amoxicillin, and clarithromycin was performed again, resulting in successful eradication of the organism. Pediatric cases with H. heilmannii infection reported are reviewed...
  7. pmc Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing
    K Trebesius
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    J Clin Microbiol 39:1510-6. 2001
    Gastric infection with Helicobacter heilmannii (previously known as Gastrospirillum hominis) is invariably linked with the presence of chronic gastritis and the risk of developing low-grade mucosa-associated lymphoid tissue lymphoma in ..
  8. ncbi The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms
    B Iwanczak
    Department of Pediatrics, Gastroenterology and Nutrition, Medical University of Wroclaw, Wroclaw, Poland
    J Physiol Pharmacol 63:133-6. 2012
    b>Helicobacter heilmannii (H. heilmannii) infection is a relatively rare causative agent of gastroduodenal diseases in children. However, H...
  9. ncbi Description of 'Candidatus Helicobacter heilmannii' based on DNA sequence analysis of 16S rRNA and urease genes
    Jani L O'Rourke
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia, 2052
    Int J Syst Evol Microbiol 54:2203-11. 2004
    ..and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as 'Helicobacter heilmannii' or 'Gastrospirillum hominis'...
  10. pmc Evaluation of "Helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogs
    Simon L Priestnall
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14851, USA
    J Clin Microbiol 42:2144-51. 2004
    Infection with candidatus "Helicobacter heilmannii" is associated with gastritis and mucosa-associated lymphoid tissue lymphoma in people. Infection with "H...
  11. pmc A cultured strain of "Helicobacter heilmannii," a human gastric pathogen, identified as H. bizzozeronii: evidence for zoonotic potential of Helicobacter
    K Jalava
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Emerg Infect Dis 7:1036-8. 2001
    We compared the characteristics of a cultured human "Helicobacter heilmannii" isolate with those of other helicobacters found in animals...
  12. pmc Characterization of a culturable "Gastrospirillum hominis" (Helicobacter heilmannii) strain isolated from human gastric mucosa
    L P Andersen
    Department of Clinical Microbiology, National University Hospital Rigshospitalet, Statens Serum Institut, Copenhagen, Hillerod Sygehus, Hillerod, Denmark
    J Clin Microbiol 37:1069-76. 1999
    ..Only corkscrew-shaped organisms resembling "Gastrospirillum hominis" ("Helicobacter heilmannii") but no Helicobacter pylori-like organisms were seen in histological sections. H...
  13. ncbi Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection
    J L O'Rourke
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Pathol 203:896-903. 2004
    ..small percentage of human infections have been associated with another organism, commonly referred to as 'Helicobacter heilmannii', which is more prevalent in a range of animal species...
  14. ncbi Increased apoptosis and angiogenesis in gastric low-grade mucosa-associated lymphoid tissue-type lymphoma by Helicobacter heilmannii infection in C57/BL6 mice
    Kaori Nishikawa
    3 Department of Internal Medicine, Kyorin University, Mitaka, Tokyo, Japan
    FEMS Immunol Med Microbiol 50:268-72. 2007
    b>Helicobacter heilmannii has been reported to cause gastric low-grade mucosa-associated lymphoid tissue-type (MALT) lymphoma, but its precise pathophysiological mechanism remains to be clarified...
  15. doi Non-Helicobacter pylori helicobacters detected in the stomach of humans comprise several naturally occurring Helicobacter species in animals
    Margo Baele
    Department of Pathology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    FEMS Immunol Med Microbiol 55:306-13. 2009
    ..These organisms have been designated 'Helicobacter heilmannii'. However, sequencing of several genes detected in NHPH-infected tissues has shown that the 'H...
  16. ncbi Detection of non-pylori Helicobacter species in "Helicobacter heilmannii"-infected humans
    Dominic De Groote
    Technology Transfer Office, Ghent University, Lammerstraat 35, B 9000 Ghent, Belgium
    Helicobacter 10:398-406. 2005
    ..Circumstantial evidence has suggested that these bacteria, also referred to as "Helicobacter heilmannii"-like organisms (HHLO), may be transmitted through animals...
  17. ncbi Comparison of gastritis and gastric epithelial proliferation in Helicobacter heilmannii-infected nude and BALB/c mice
    R A Peterson
    Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA
    Vet Pathol 38:173-83. 2001
    ..Additionally, CD4 immunocompetence is an integral aspect of the mucosal hypertrophy/nodular hyperplasia in experimental H. heilmannii-associated disease of mice...
  18. ncbi [Helicobacter heilmannii-associated low-grade gastric MALT lymphoma: a new case of complete remission after eradication]
    Laurence Thomas-Marques
    Gastroenterol Clin Biol 29:476-7. 2005
  19. pmc "Candidatus Helicobacter heilmannii" from a cynomolgus monkey induces gastric mucosa-associated lymphoid tissue lymphomas in C57BL/6 mice
    Masahiko Nakamura
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Infect Immun 75:1214-22. 2007
    Both Helicobacter pylori and "Candidatus Helicobacter heilmannii" infections are associated with peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (MALT) lymphomas. However, good animal models of H...
  20. ncbi [A case of gastric ulcer induced by Helicobacter heilmannii-like organism]
    Woo Jong Seo
    Department of Internal Medicine, Pohang St Mary s Hospital, Pohang, Korea
    Korean J Gastroenterol 42:63-6. 2003
    ..pylori), which was classified as Helicobacter heilmannii (H. heilmannii)...
  21. ncbi Development and application of a novel screening PCR assay for direct detection of 'Helicobacter heilmannii'-like organisms in human gastric biopsies in Southeast England
    Stephanie A Chisholm
    Laboratory of Enteric Pathogens, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    Diagn Microbiol Infect Dis 46:1-7. 2003
    A novel PCR assay (HHLO-16) to screen for presence of 'Helicobacter heilmannii'-like organisms (HHLO) direct from gastric biopsies is described. As 'H...
  22. doi Gastric Infection with Kazachstania heterogenica influences the outcome of a Helicobacter suis infection in Mongolian gerbils
    Bram Flahou
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Helicobacter 15:67-75. 2010
    ..After identification, we have investigated the effect of the gastric yeast infection on the outcome of an experimental H. suis infection in Mongolian gerbils...
  23. pmc Helicobacter heilmannii gastritis: a histological and immunohistochemical trait
    E Ierardi
    Department of Emergency and Organ Transplantation, Section of Gastroenterology, University of Bari, 70124 Bari, Italy
    J Clin Pathol 54:774-7. 2001
    AIM: Biopsies of the gastric antrum were reviewed over a period of 10 years to determine the prevalence of Helicobacter heilmannii in symptomatic subjects from this geographical area and to relate its presence to distinctive ..
  24. ncbi Helicobacter heilmannii infection: clinical, endoscopic and histopathological features in Japanese patients
    Yoko Okiyama
    Second Department of Internal Medicine, Shinshu University School of Medicine, Shinshu University, Nagano, Japan
    Pathol Int 55:398-404. 2005
    ..patients undergoing esophagogastroduodenoscopy were reviewed, along with those of 15 patients with Helicobacter heilmannii infection (11, chronic gastritis; four, mucosa-associated lymphoid tissue (MALT) lymphoma)...
  25. ncbi The role of IFN-gamma and IL-4 in gastric mucosa inflammation associated with Helicobacter heilmannii type 1 infection
    S M S Cinque
    Laboratório de Pesquisa em Bacteriologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Braz J Med Biol Res 39:253-61. 2006
    Although Helicobacter heilmannii infection is less common than H...
  26. doi Gastric lesions and immune responses caused by long-term infection with Helicobacter heilmannii in C57BL/6 mice
    Jong Hwan Park
    Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56 1, Sillim 9 Dong, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Comp Pathol 139:208-17. 2008
    b>Helicobacter heilmannii is a gastric micro-organism that can induce gastritis and B-cell MALT (mucosa-associated lymphoid tissue) lymphoma in mice, in a host-dependent manner...
  27. ncbi Gastritis and carditis
    David A Owen
    University of British Columbia, Vancouver, British Columbia, Canada
    Mod Pathol 16:325-41. 2003
    ..Carditis is a controversial topic: currently opinions are divided as to whether it is the result of gastroesophageal reflux or a proximal extension of H. pylori infection from the remainder of the stomach...
  28. ncbi First report on the occurrence of 'Helicobacter heilmannii' in the stomach of rabbits
    K Van den Bulck
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    Vet Res Commun 29:271-9. 2005
    ..In view of the fact that H. felis and H. salomonis are put forward as having zoonotic potential, further research is necessary to investigate the implications of these findings not only for the rabbit but also for human health...
  29. ncbi [Relation of Helicobacter heilmannii to gastric mucosal damage as a model of zoonosis between men and pets]
    Masahiko Nakamura
    Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
    Nihon Rinsho 63:605-8. 2005
  30. ncbi Experimental infection of pigs with 'Candidatus Helicobacter suis'
    A Hellemans
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Belgium
    Vet Res Commun 31:385-95. 2007
    ..No apparent inflammation of the fundic stomach region was detected in the infected animals. A clear link between 'Candidatus Helicobacter suis' and pars oesophageal lesions could not be found...
  31. ncbi Acute symptomatic gastritis due to Helicobacter heilmannii
    Waleed K Al-Hamoudi
    Division of Gastroenterology, Department of Pathology, Sir Mortimer B Davis Jewish General Hospital, McGill University School of Medicine, 3755 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada
    Helicobacter 11:446-50. 2006
    b>Helicobacter heilmannii is a Gram-negative spiral-shaped organism predominantly associated with zoonotic infection. Human pathology has also been described, but acute symptoms with complete resolution have been infrequently reported...
  32. ncbi Helicobacter heilmannii gastritis caused by cat to child transmission
    Sandra van Loon
    Department of Pediatric Gastroenterolgy, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
    J Pediatr Gastroenterol Nutr 36:407-9. 2003
  33. ncbi Clinical significance of Helicobacter species other than Helicobacter pylori
    Jay V Solnick
    Department of Internal Medicine Infectious Diseases, School of Medicine, University of California, Davis, CA 95616, USA
    Clin Infect Dis 36:349-54. 2003
    ....
  34. ncbi A case of acute gastric mucosal lesions associated with Helicobacter heilmannii infection
    Masaya Yoshimura
    Internal Medicine, Omura Municipal Hospital, 132 1 Kogashima, Omura, Japan
    Helicobacter 7:322-6. 2002
    ..neutrophilic gastritis and single longer and more coiled organisms than Helicobacter pylori, suggesting Helicobacter heilmannii. Electron micropragh confirmed the characteristic morphology. Despite a positive rapid urease test, H...
  35. ncbi Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years
    Lyudmila Boyanova
    Department of Microbiology, Medical University of Sofia, Zdrave Street 2, 1431 Sofia, Bulgaria
    J Med Microbiol 56:1081-5. 2007
    The aims of the study were to evaluate the incidence of Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children from 1996 to 2006, to analyse the performance of diagnostic tests, and to look at H...
  36. pmc Gastric Helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis
    Erin C Bridgeford
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825, Cambridge, MA 02139, United States
    Vet Immunol Immunopathol 123:106-13. 2008
    ..The present study examined the association of Helicobacter heilmannii (Hhe) infection in pet cats with feline gastric mucosa associated lymphoid tissue (MALT) lymphoma...
  37. ncbi A report of two children with Helicobacter heilmannii gastritis and review of the literature
    Cary M Qualia
    Division of Pediatric Gastroenterology and Nutrition, University of Rochester Medical Center, 601 Elmwood Ave, Box 667, Rochester, NY 14642, USA
    Pediatr Dev Pathol 10:391-4. 2007
    ..gastric antrum of both children revealed corkscrew-like spiral bacteria, consistent with the diagnosis of Helicobacter heilmannii infection. H. heilmannii is a rare finding in children and is thought to be present in approximately 0...
  38. ncbi Persistent increase in myofibroblasts in Helicobacter heilmannii-infected mice but not in Helicobacter pylori-infected Mongolian gerbils: colocalization of COX-2 and bFGF immunoreactivity
    M Nakamura
    Center for Basic Research, The Kitasato Institute, Kitasato University, Minato ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:174-9. 2002
    The clinical significance of Helicobacter heilmannii infection remains uncertain, owing to the lack of a specific detection method...
  39. doi Helicobacter spp. other than Helicobacter pylori
    Arinze S Okoli
    School of Medicine, Sydney, The University of Notre Dame Australia, 160 Oxford St, Darlinghurst, NSW 2010, Australia
    Helicobacter 14:69-74. 2009
    ..More findings support an association between Helicobacter heilmannii and gastric adenocarcinoma; and in mice, mucins MUC4 and MUC5 but not MUC1 influence the colonization and ..
  40. pmc Detection of "Candidatus Helicobacter suis" in gastric samples of pigs by PCR: comparison with other invasive diagnostic techniques
    D De Groote
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, University of Ghent, B 9820 Merelbeke, Belgium
    J Clin Microbiol 38:1131-5. 2000
    ..suis" in the stomachs of pigs and could prove to be a valuable tool for further epidemiological studies both for "Candidatus H. suis"- and for "Helicobacter heilmannii" type 1-related research.
  41. ncbi Gastrin release and gastric acid secretion in the rat infected with either Helicobacter felis or Helicobacter heilmannii
    S J Danon
    School of Microbiology and Immunology, The University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 13:95-103. 1998
    ..The gastric bacteria Helicobacter felis and Helicobacter heilmannii colonize the antrum of rats in large numbers and induce no significant inflammatory response...
  42. pmc Identification of non-Helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats
    Kathleen Van den Bulck
    Department of Pathology, Bacteriology, and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Clin Microbiol 43:2256-60. 2005
    ..salomonis in human gastric biopsy samples is in contrast to its rare identification in pet carnivore samples, urging us to suspect other sources of infection...
  43. ncbi 'Candidatus Helicobacter suis', a gastric helicobacter from pigs, and its phylogenetic relatedness to other gastrospirilla
    D De Groote
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
    Int J Syst Bacteriol 49:1769-77. 1999
    ..gastrospirillum-like bacteria (Helicobacter felis, Helicobacter bizzozeronii, Helicobacter salomonis and 'Helicobacter heilmannii' types 1 and 2)...
  44. doi Isolation and characterization of Helicobacter suis sp. nov. from pig stomachs
    M Baele
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 58:1350-8. 2008
    ..that the strains present in the gastric mucosa of pigs constituted a separate taxon, corresponding to 'Helicobacter heilmannii' type 1 strains as detected in the gastric mucosa of humans and other primates...
  45. pmc Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health
    Freddy Haesebrouck
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Clin Microbiol Rev 22:202-23, Table of Contents. 2009
    ..felis, H. salomonis, H. bizzozeronii, and the still-uncultivable "Candidatus Helicobacter heilmannii." These microorganisms are often detected in the stomachs of dogs and cats...
  46. ncbi Helicobacter cynogastricus sp. nov., isolated from the canine gastric mucosa
    K Van den Bulck
    Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 56:1559-64. 2006
    ..felis, H. bizzozeronii, H. salomonis and "Candidatus Helicobacter heilmannii"...
  47. ncbi The first description of gastric Helicobacter in free-ranging wild boar (Sus scrofa) from Poland
    M Fabisiak
    Department of Clinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Warsaw, Poland
    Pol J Vet Sci 13:171-4. 2010
    ..Obtained sequence analysis showed its relatedness to Helicobacter heilmannii type 2...
  48. pmc Multiplex PCR assay for differentiation of Helicobacter felis, H. bizzozeronii, and H. salomonis
    M Baele
    Department of Pathology, Bacteriology, and Avian Diseases, Ghent University, Merelbeke, Belgium
    J Clin Microbiol 42:1115-22. 2004
    ..Helicobacter suis," our procedure was shown to be very useful in determining the species identity of "Helicobacter heilmannii"-like organisms observed in human stomachs and will facilitate research concerning their possible ..
  49. ncbi [Latest advances in non-pylori Helicobacter species]
    Shunji Hayashi
    Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University
    Nihon Rinsho 67:2271-8. 2009
    ..It remains unclear whether they are associated with human diseases. 'Helicobacter heilmannii' causes human chronic gastritis...
  50. doi Characterization of multiple Helicobacter bizzozeronii isolates from a Finnish patient with severe dyspeptic symptoms and chronic active gastritis
    Rauni Kivistö
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    Helicobacter 15:58-66. 2010
    ..patients with upper gastrointestinal symptoms, long tightly coiled spiral bacteria, provisionally named "Helicobacter heilmannii," are observed in gastric biopsies...
  51. ncbi Detection of Helicobacter pylori infection in symptomatic Bulgarian adults
    L Boyanova
    Department of Microbiology, Medical University of Sofia, Bulgaria
    Clin Microbiol Infect 13:908-14. 2007
    ..3% and 56.1%, respectively, of other adults were H. pylori-positive. Two (0.1%) non-treated adults were Helicobacter heilmannii-positive. The accuracy of direct Gram's stain and the in-house RUT were 74.8% and 64...
  52. pmc Growth of Helicobacter pylori in a long spiral form does not alter expression of immunodominant proteins
    Kathleen M B Vinette
    Immunology Laboratory, Department of Research, Alfred I, duPont Hospital for Children, Wilmington, Delaware, USA
    BMC Microbiol 2:24. 2002
    ..induce a strain of Helicobacter pylori to assume a long spiral morphology resembling that described for Helicobacter heilmannii. The present study was initiated to determine if other strains of H...
  53. doi Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of "Candidatus Helicobacter heilmannii"-induced gastritis and gastr
    Akira Suzuki
    Department of Surgery, Shinshu University Hospital, Matsumoto, Japan
    Helicobacter 15:538-48. 2010
    Candidatus Helicobacter heilmannii" induce chronic gastritis, which eventually leads to gastric B-cell type mucosa-associated lymphoid tissue (MALT) lymphoma...
  54. ncbi The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment
    M Stolte
    Department of Pathology, Klinikum Bayreuth, Preuschwitzerstrasse 101, 95445 Bayreuth, Germany
    Can J Gastroenterol 15:591-8. 2001
    ..gastritis unassociated with H pylori, can be differentiated into autoimmune, chemically induced reactive gastritis, ex-H pylori gastritis, Helicobacter heilmannii gastritis, Crohn's gastritis and a number of special forms of gastritis.
  55. doi Metabolic versatility of the Riftia pachyptila endosymbiont revealed through metagenomics
    Julie C Robidart
    Scripps Institution of Oceanography, San Diego, CA, USA
    Environ Microbiol 10:727-37. 2008
    ..The physiology of Candidatus Endoriftia persephone is explored with respect to functionality while associated with a eukaryotic host, versus free-living in the hydrothermal environment...
  56. ncbi Helicobacter pylori-negative peptic ulcer. What is its aetiopathogenesis and treatment?
    J Monés Xiol
    Gastroenterology Unit, Santa Creu i Sant Pau Hospital, Universidad Autonoma, Barcelona, Spain
    Rev Esp Enferm Dig 94:687-96. 2002
    ..3. Other causes (Zollinger-Ellison syndrome, Helicobacter heilmannii, generalised gut disease such as Crohn's disease, amyloidosis, eosinophilic gastroenteritis, etc...
  57. ncbi Reproduction of severe gastroesophageal ulcers (GEU) in gnotobiotic swine infected with porcine Helicobacter pylori-like bacteria
    S Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Vet Pathol 43:956-62. 2006
    Groups of gnotobiotic piglets were orally inoculated at 3 days of age with either Helicobacter heilmannii (Hh) or a newly described porcine-origin gastric Helicobacter pylori (Hp)-like bacterium...
  58. ncbi The high prevalence of Helicobacter sp. in porcine pyloric mucosa and its histopathological and molecular characteristics
    Jong Hwan Park
    Department of Laboratory Animal Medicine, School of Agricultural Biotechnology, College of Veterinary Medicine, Seoul National University, San 56 1, Sillim dong, Kwanak gu, Seoul 151 742, South Korea
    Vet Microbiol 104:219-25. 2004
    ..The PCR product (376 bp) was digested with NdeII to differentiate between Helicobacter heilmannii and Helicobacter pylori...
  59. pmc Multilocus sequence typing of the porcine and human gastric pathogen Helicobacter suis
    Jungang Liang
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Clin Microbiol 51:920-6. 2013
    ..The human H. suis strain showed a very close relationship to porcine strains. In conclusion, the developed MLST scheme may prove useful for direct, culture-independent typing of porcine and human H. suis strains...
  60. doi Helicobacter heilmannii sp. nov., isolated from feline gastric mucosa
    A Smet
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 62:299-306. 2012
    ..98 to 99 % sequence similarity to strains of Helicobacter felis, Helicobacter bizzozeronii, 'Candidatus Helicobacter heilmannii', Helicobacter cynogastricus, Helicobacter baculiformis and Helicobacter salomonis, six related ..
  61. pmc Detection and prevalence of Helicobacter infection in pet cats
    R Neiger
    Gastroenterology Unit, Inselspital, Bern, Switzerland
    J Clin Microbiol 36:634-7. 1998
    ..PCR analysis revealed that 78% of the cats (38 of 49) were infected by Helicobacter heilmannii; however, none of them was harboring Helicobacter pylori or Helicobacter felis...
  62. ncbi [Gastritis caused by Helicobacter heilmannii (Gastrospirillum hominis). Report of 3 cases]
    R Bartolomé Resano
    Medico de Familia, Hospital de Navarra, Santa Soria, Navarra
    Gastroenterol Hepatol 24:202-4. 2001
    b>Helicobacter heilmannii infection is rare...
  63. doi Protective immunization with homologous and heterologous antigens against Helicobacter suis challenge in a mouse model
    Bram Flahou
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vaccine 27:1416-21. 2009
    ..suis, but complete protection was only achieved in a minority of animals following intranasal immunization...
  64. ncbi Helicobacter felis does not stimulate human neutrophil oxidative burst in contrast to 'Gastrospirillum hominis' and Helicobacter pylori
    T K Hansen
    Department of Clinica Microbiology, 7806, National University Hospital Rigshospitalet, Tagensvej 20, 2200 Copenhagen, Denmark
    FEMS Immunol Med Microbiol 30:187-95. 2001
    ....
  65. ncbi [Endoscopic aspect of ulcerated tumor-like gastritis associated with Helicobacter heilmannii]
    P Texereau
    , , Mont-de-Marsan
    Gastroenterol Clin Biol 25:543-5. 2001
    ..cases with an endoscopic aspect exceptionally described of ulcerated tumor-like gastritis associated with Helicobacter heilmannii. This rare but ubiquitary bacteria, belonging to the same family as Helicobacter pylori, is ..
  66. ncbi Pathogenic role of gastric Helicobacter sp in domestic carnivores
    P Lecoindre
    Association lyonnaise de gastroentérologie comparée ALGEC, Lyon, France
    Vet Res 28:207-15. 1997
    ..This ubiquitous character has led some scientists to consider the potential zoonotic risk of the human infection by Helicobacter heilmannii, felis or pylori.
  67. ncbi Prevalence of 'Candidatus Helicobacter suis' in pigs of different ages
    A Hellemans
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Rec 161:189-92. 2007
    ..The agreement between the results obtained with the pcr test and the urease test was very good for some age groups and sampling sites, but poor for other age groups and sampling sites...
  68. doi Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice
    Y Ben Suleiman
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Mucosal Immunol 5:87-98. 2012
    ..C57BL/6J wild-type or FcRn(-/-) mice were infected with Helicobacter heilmannii, and gastric lesions, bacterial load and the levels of antigen-specific IgG in serum and gastric juice ..
  69. ncbi Increased gastric emptying induced by Helicobacter heilmannii type 1 infection in rats
    I Duval-Araujo
    Laboratory of Research in Bacteriology, Medical School, University Hospital, Universidade Federal de Minas Gerais, Brazil
    J Med Microbiol 49:627-34. 2000
    ..In addition, infected animals showed evidence of gastritis on histological examination. Gastric motility is altered in rats infected with Hh1, a fact possibly related to concurrent abnormalities of gastrin and somatostatin secretion...
  70. pmc Comparative genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humans
    Thomas Schott
    Department of Food Hygiene and Environmental Health DFHEH, Faculty of Veterinary Medicine, University of Helsinki, P, O, Box 66, FI 00014 University of Helsinki, Finland
    BMC Genomics 12:534. 2011
    The canine Gram-negative Helicobacter bizzozeronii is one of seven species in Helicobacter heilmannii sensu lato that are detected in 0.17-2.3% of the gastric biopsies of human patients with gastric symptoms. At the present, H...
  71. pmc Slaughter pigs are commonly infected by closely related but distinct gastric ulcerative lesion-inducing gastrospirilla
    R Roosendaal
    Department of Medical Microbiology and Infection Control, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
    J Clin Microbiol 38:2661-4. 2000
    ..analysis of 43 16S rDNA fragments (out of 54 PCR-positive biopsy specimens) revealed the presence of Helicobacter heilmannii type 1 in 42 of them. This correlated with the presence of bacteria with GLO morphology...
  72. ncbi Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection
    A Morgner
    Medical Department I, Technical University, Dresden, Germany
    Gastroenterology 118:821-8. 2000
    ..This study investigated whether Helicobacter heilmannii infection-associated primary gastric MALT lymphoma will regress after cure of the infection.
  73. pmc Helicobacter pylori can be induced to assume the morphology of Helicobacter heilmannii
    P T Fawcett
    Immunology Laboratory, Department of Clinical Science, duPont Hospital for Children, Wilmington, Delaware
    J Clin Microbiol 37:1045-8. 1999
    ..pylori whereas bacteria from broth cultures had the morphologic appearance of Helicobacter heilmannii. Bacteria harvested from blood agar plates assumed an H...
  74. doi Suppression of lymphangiogenesis induced by Flt-4 antibody in gastric low-grade mucosa-associated lymphoid tissue lymphoma by Helicobacter heilmannii infection
    Masahiko Nakamura
    Division of Pathophysiolgy, Research and Education Center for Clinical Pharmacy, School of Pharmaceutical Sciences, Mitaka, Tokyo, Japan
    J Gastroenterol Hepatol 25:S1-6. 2010
    Our recent study revealed that per oral infection with Helicobacter heilmannii induced low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in the gastric fundus of C57BL/6 mice after a period of 6 months, although the ..
  75. doi Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway
    Kentaro Nobutani
    Department of Internal Medicine, Division of Gastroenterology, Kobe University Graduate School of Medicine, Hyogo, Japan
    FEMS Immunol Med Microbiol 60:156-64. 2010
    b>Helicobacter heilmannii induces gastric lymphoid follicles in mice. However, the pathogenic mechanisms behind the induction of gastric lymphoid follicles by H. heilmannii infection have not been elucidated...
  76. ncbi Helicobacter heilmannii gastritis: a case study with review of literature
    Anuradha V Singhal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Surg Pathol 29:1537-9. 2005
    ..heilmannii gastritis. The use of immunohistochemical stain to identify H. heilmannii may be useful in cases with a paucity of organisms, with suggestive but not diagnostic forms on routine hematoxylin and eosin stain...
  77. doi Helicobacter baculiformis sp. nov., isolated from feline stomach mucosa
    M Baele
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 58:357-64. 2008
    ..felis, Helicobacter bizzozeronii, Helicobacter salomonis, Helicobacter cynogastricus and 'Candidatus Helicobacter heilmannii', five highly related species previously detected in the feline or canine gastric mucosa...
  78. doi Acute gastritis associated with invading Helicobacter heilmannii organisms from a previously homeless cat
    Hiroshi Ohtani
    J Clin Gastroenterol 42:216-7. 2008
  79. ncbi Are goats naturally resistant to gastric Helicobacter infection?
    Pulcherie Gueneau
    Laboratorio de Fisiologia Gastrointestinal, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Vet Microbiol 84:115-21. 2002
    ..We discuss the possibility that goats may exhibit natural resistance to abomasal infection by Helicobacter spp...
  80. ncbi The relationship of a Helicobacter heilmannii infection to the mucosal changes in abattoir and laboratory pig stomach
    Anwar S Mall
    Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Surg Today 34:943-9. 2004
    ..extends into the pig stomach) by bile duct ligation (BDL) was used in this study to determine whether Helicobacter heilmannii (Hh) is a predisposing factor in the ulceration of this region...
  81. ncbi Protective immunization against "Candidatus Helicobacter suis" with heterologous antigens of H. pylori and H. felis
    A Hellemans
    Laboratory of Pathology, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vaccine 24:2469-76. 2006
    ..Since PCR on stomach tissue samples at 16 weeks after challenge infection could still detect "Candidatus H. suis DNA" in all immunisation-challenge groups, complete clearance of challenge bacteria was not achieved...
  82. ncbi Helicobacter heilmannii infection in a child
    Dennis C Wooten
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Tex 75235, USA
    Arch Pathol Lab Med 128:1461-2. 2004
  83. pmc Evaluation of antibiotic treatment against "Candidatus Helicobacter suis" in a mouse model
    A Hellemans
    Laboratory of Pathology, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Antimicrob Agents Chemother 49:4530-5. 2005
    b>Helicobacter heilmannii" (proposed name) type 1 colonizes the human stomach. It has been shown to be identical to "Candidatus Helicobacter suis," a Helicobacter species colonizing the stomachs of >60% of slaughter pigs...
  84. ncbi [Repeated abdominal pain in an 11 year old. Cats or stress?]
    Juhani Grönlund
    TYKS n lastenklinikka, Turku
    Duodecim 120:2919-21. 2004
  85. ncbi Helicobacter pylori and extragastric diseases--other Helicobacters
    Hans Olof Nilsson
    Department of Laboratory Medicine, Lund University, Lund, Sweden
    Helicobacter 10:54-65. 2005
    ..Previously isolated human and animal Helicobacter sp. flexispira and "Helicobacter heilmannii" strains have been validated using polyphasic taxonomy...
  86. ncbi Gastroinvasive Helicobacter infection in an Ocelot (Leopardus pardalis)
    Y Kanou
    Ishikari Livestock Hygiene Service Centre, 3 Hitsujigaoka, Toyohira, Sapporo 062 0045, Japan
    J Comp Pathol 133:281-5. 2005
    ..The bacteria, resembling Helicobacter heilmannii, were located largely within canaliculi or in the cytosol of parietal cells...
  87. ncbi Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 1: eradication of Helicobacter in the cachexia of idiopathic parkinsonism
    R John Dobbs
    Section of Clinical Neuropharmacology, Institute of Psychiatry, London, UK
    Helicobacter 10:267-75. 2005
    ..Neuronal damage in idiopathic parkinsonism may be in response to ubiquitous occult infection. Since peptic ulceration is prodromal, Helicobacter is a prime candidate...
  88. ncbi Images in pathology: Helicobacter heilmannii gastritis
    Xia Chen
    Department of Pathology, New York Presbyterian Hospital Weill Cornell Center, New York, NY, USA
    Int J Surg Pathol 11:315. 2003
  89. ncbi Gastritis associated with Helicobacter-like organisms in baboons
    J T Mackie
    Idexx Veterinary Pathology Services, PO Box 1119, Coorparoo DC, Qld 4151, Australia
    Vet Pathol 40:563-6. 2003
    ..pylori and H. heilmannii. This is the first report of gastritis associated with Helicobacter-like organisms in baboons...
  90. ncbi Effect of Helicobacter sp. infection on the number of antral gastric endocrine cells in swine
    R Sapierzynski
    Department of Clinical Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University SGGW, Nowoursynowska 159C, 02 766 Warsaw, Poland
    Pol J Vet Sci 10:65-70. 2007
    ..Some of these alterations, for example increase the number of G cells, decrease of the D cells and especially increase of ratio G to D cells can be responsible for development of gastroesophageal ulcers in swine...
  91. ncbi [Helicobacter heilmannii-associated gastritis]
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine
    Nihon Rinsho 60:791-5. 2002
  92. ncbi Cellular immune responses in Helicobacter heilmannii infection: evaluation of the role of the host and the bacterium
    S M S Cinque
    Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Dig Dis Sci 47:823-30. 2002
    We evaluated some aspects of the immune response to Helicobacter heilmannii in two mouse strains. Gastritis that was more severe in infected C57BL/6 mice. A proliferative response to H. pylori antigens was observed in splenocytes from H...
  93. ncbi Cryptosporidium muris-like infection in stomach of cynomolgus monkeys (Macaca fascicularis)
    J P Dubey
    Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705 2350, USA
    Vet Pathol 39:363-71. 2002
    ..primarily present in the upper one third of fundic glands that were often concurrently colonized by a Helicobacter heilmannii-like organism; however, no clear correlation was found between bacterial burden and the number of ..
  94. pmc Spiral bacteria in the human stomach: the gastric helicobacters
    A Dubois
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Emerg Infect Dis 1:79-85. 1995
    ..In this second decade of intensive research, it is important to understand why H. pylori is sometimes a dangerous pathogen, and to determine how it can be eradicated in those at highest risk for severe disease...
  95. ncbi Helicobacter heilmannii as causative agent of chronic active gastritis
    Nese Kaklikkaya
    Department of Microbiology, Karadeniz Technical University Medical School, Trabzon, Turkey
    Scand J Infect Dis 34:768-70. 2002
  96. ncbi Helicobacter pylori and Helicobacter heilmannii in children. A Bulgarian study
    Lyudmila Boyanova
    Department of Microbiology, Medical University of Sofia, Sofia, Bulgaria
    Diagn Microbiol Infect Dis 46:249-52. 2003
    The aim of the study was to evaluate the prevalence of Helicobacter pylori and Helicobacter heilmannii among 321 children. Gram staining, urease test and culture were performed. Of all patients, 52.6% were H. pylori positive and 0...
  97. ncbi Peptic ulcer disease associated with Helicobacter felis in a dog owner
    Manuelle De Bock
    Department of Pathology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Eur J Gastroenterol Hepatol 19:79-82. 2007
    The aim of this study was to investigate the identity of the Helicobacter heilmannii-like bacteria found in the stomach of a human patient suffering from stomach ulcers and her asymptomatic pet dog...
  98. ncbi Development of a microelectronic chip array for high-throughput genotyping of Helicobacter species and screening for antimicrobial resistance
    James Z Xing
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biomol Screen 10:235-45. 2005
    A microelectronic array assay was developed to specifically genotype Helicobacter pylori versus Helicobacter heilmannii and to determine antimicrobial resistance...

Research Grants32

  1. Modification of Helicobacter pylori Lipid A
    MICHAEL TRENT; Fiscal Year: 2004
    ..Secondly, the lipid A structure of Helicobacter heilmannii will be investigated. H...
  2. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  3. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  4. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  5. DETERMINANTS OF H PYLORI INFECTION IN THE RHESUS MONKEY
    JAY SOLNICK; Fiscal Year: 2001
    ..The results will be compared in juvenile and adult animals. These studies will further understanding of the host-pathogen relationship in acute and chronic H. pylori infection. ..
  6. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2010
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  7. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2010
    ..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
  8. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..If the encouraging results from mouse studies can be replicated in non-human primates, they would serve as the basis for PhaseI/II clinical trials in humans. ..
  9. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  10. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    Jay V Solnick; Fiscal Year: 2010
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  11. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    JAY SOLNICK; Fiscal Year: 2009
    ..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
  12. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..These experiments could lead to development of a vaccine to prevent and treat Helicobacter pylori infection, which would likely reduce the frequency of peptic ulcer disease and gastric cancer. ..
  13. Transcription of H. pylori Genes in the Rhesus Monkey
    JAY SOLNICK; Fiscal Year: 2002
    ..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
  14. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2003
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  15. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  16. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2006
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  17. Animal Models of Infection Diseases Training Program
    JAY SOLNICK; Fiscal Year: 2007
    ..Our goal is to become a pre-eminent training center in the use of animal models and the new genomic biology to better understand human infectious diseases. ..