streptococcus

Summary

Summary: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

Top Publications

  1. pmc Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China
    Ying Ma
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, The People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 364:2725-37. 2009
  2. pmc Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition
    Tristan Lefebure
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genome Biol 8:R71. 2007
  3. pmc Catabolite control protein A controls hydrogen peroxide production and cell death in Streptococcus sanguinis
    Lanyan Zheng
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Bacteriol 193:516-26. 2011
  4. pmc Streptococcus adherence and colonization
    Angela H Nobbs
    Oral Microbiology Unit, Department of Oral and Dental Science, University of Bristol, Bristol BS1 2LY, United Kingdom
    Microbiol Mol Biol Rev 73:407-50, Table of Contents. 2009
  5. pmc What happened to the streptococci: overview of taxonomic and nomenclature changes
    Richard Facklam
    Streptococcus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 15:613-30. 2002
  6. doi Transcriptome profiling of Streptococcus uberis-induced mastitis reveals fundamental differences between immune gene expression in the mammary gland and in a primary cell culture model
    K M Swanson
    AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand
    J Dairy Sci 92:117-29. 2009
  7. pmc Comparative genomic analysis of the Streptococcus dysgalactiae species group: gene content, molecular adaptation, and promoter evolution
    Haruo Suzuki
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York
    Genome Biol Evol 3:168-85. 2011
  8. ncbi Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales
    A J Bradley
    School of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 160:253-7. 2007
  9. pmc Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis
    Christophe Rusniok
    Institut Pasteur, Unité de Biologie des Bactéries Intracellulaires, CNRS URA 2171, Paris, France
    J Bacteriol 192:2266-76. 2010
  10. pmc Fusobacterium nucleatum transports noninvasive Streptococcus cristatus into human epithelial cells
    Andrew M Edwards
    Department of Diagnostic and Biological Sciences, School of Dentistry, 17 252 Moos Tower, 515 Delaware Street S E, Minneapolis, MN 55455, USA
    Infect Immun 74:654-62. 2006

Detail Information

Publications317 found, 100 shown here

  1. pmc Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China
    Ying Ma
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, The People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 364:2725-37. 2009
    ..bacteria can also expand their host range: a new disease, streptococcal toxic shock syndrome, caused by human Streptococcus suis serotype 2 infection, has been observed in China with 52 human fatalities in two separate outbreaks (1998 ..
  2. pmc Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition
    Tristan Lefebure
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genome Biol 8:R71. 2007
    The genus Streptococcus is one of the most diverse and important human and agricultural pathogens...
  3. pmc Catabolite control protein A controls hydrogen peroxide production and cell death in Streptococcus sanguinis
    Lanyan Zheng
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Bacteriol 193:516-26. 2011
    b>Streptococcus sanguinis is a commensal oral bacterium producing hydrogen peroxide (H₂O₂) that is dependent on pyruvate oxidase (Spx) activity...
  4. pmc Streptococcus adherence and colonization
    Angela H Nobbs
    Oral Microbiology Unit, Department of Oral and Dental Science, University of Bristol, Bristol BS1 2LY, United Kingdom
    Microbiol Mol Biol Rev 73:407-50, Table of Contents. 2009
    ..Collectively, these surface-bound proteins provide Streptococcus species with a "coat of many colors," enabling multiple intimate contacts and interplays between the bacterial ..
  5. pmc What happened to the streptococci: overview of taxonomic and nomenclature changes
    Richard Facklam
    Streptococcus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 15:613-30. 2002
    Since the division of the Streptococcus genus into enterococci, lactococci, and streptococci in 1984, many changes in the nomenclature and taxonomy of the Streptococcus genus have taken place...
  6. doi Transcriptome profiling of Streptococcus uberis-induced mastitis reveals fundamental differences between immune gene expression in the mammary gland and in a primary cell culture model
    K M Swanson
    AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand
    J Dairy Sci 92:117-29. 2009
    b>Streptococcus uberis is a prevalent causative organism of mastitis and resides naturally in the environment of the dairy cow making prevention of the disease difficult...
  7. pmc Comparative genomic analysis of the Streptococcus dysgalactiae species group: gene content, molecular adaptation, and promoter evolution
    Haruo Suzuki
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York
    Genome Biol Evol 3:168-85. 2011
    ..b>Streptococcus dysgalactiae (SD) is comprised of two subspecies: S. dysgalactiae subsp...
  8. ncbi Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales
    A J Bradley
    School of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 160:253-7. 2007
    ..b>Streptococcus uberis and Escherichia coli were isolated in pure culture from 23.5 per cent and 19...
  9. pmc Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis
    Christophe Rusniok
    Institut Pasteur, Unité de Biologie des Bactéries Intracellulaires, CNRS URA 2171, Paris, France
    J Bacteriol 192:2266-76. 2010
    b>Streptococcus gallolyticus (formerly known as Streptococcus bovis biotype I) is an increasing cause of endocarditis among streptococci and frequently associated with colon cancer. S...
  10. pmc Fusobacterium nucleatum transports noninvasive Streptococcus cristatus into human epithelial cells
    Andrew M Edwards
    Department of Diagnostic and Biological Sciences, School of Dentistry, 17 252 Moos Tower, 515 Delaware Street S E, Minneapolis, MN 55455, USA
    Infect Immun 74:654-62. 2006
    ..Fusobacterium nucleatum is capable of binding to and invading oral epithelial cells. By contrast, Streptococcus cristatus binds weakly to host cells and is not internalized. F. nucleatum and S...
  11. pmc The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing
    Annelies S Zinkernagel
    Department of Pediatrics, Division of Pharmacology and Drug Discovery, La Jolla, CA 92093, USA
    Cell Host Microbe 4:170-8. 2008
    ..The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upregulated in vivo ..
  12. ncbi Identification of a genetic determinant responsible for host specificity in Streptococcus thermophilus bacteriophages
    M Duplessis
    Departement de Biochimie et de Microbiologie, Faculte des sciences et de genie, Universite Laval, Quebec, Canada, G1K 7P4
    Mol Microbiol 41:325-36. 2001
    ..aim of this study was to identify the phage genetic determinant (anti-receptor) involved in the recognition of Streptococcus thermophilus hosts. The complete genomic sequence of the lytic S...
  13. pmc Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells
    Tanja Vollmer
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Bad Oeynhausen, Germany
    BMC Microbiol 10:78. 2010
    b>Streptococcus gallolyticus subsp. gallolyticus is an important causative agent of infective endocarditis (IE) but the knowledge on virulence factors is limited and the pathogenesis of the infection is poorly understood...
  14. ncbi Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase
    J M Loeffler
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, NY 10021, USA
    Science 294:2170-2. 2001
    Nasopharyngeal carriage is the major reservoir for Streptococcus pneumoniae in the community. Although eliminating this reservoir would greatly reduce disease occurrence, no suitable intervention has been available for this purpose...
  15. ncbi Assembly of pili in Gram-positive bacteria
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Trends Microbiol 12:228-34. 2004
  16. pmc A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator
    Lauren Mashburn-Warren
    Center for Pharmaceutical Biotechnology, College of Pharmacy, The University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Microbiol 78:589-606. 2010
    ..Deletion of comR or comS in Streptococcus mutans abolished transformability, as did deletion of the oligopeptide permease subunit oppD, suggesting that ..
  17. pmc The changing faces of Streptococcus antigen I/II polypeptide family adhesins
    L Jeannine Brady
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Mol Microbiol 77:276-86. 2010
    b>Streptococcus mutans antigen I/II (AgI/II) protein was one of the first cell wall-anchored adhesins identified in Gram-positive bacteria. It mediates attachment of S...
  18. pmc Recent advances in understanding the molecular basis of group B Streptococcus virulence
    Heather C Maisey
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0687, USA
    Expert Rev Mol Med 10:e27. 2008
    Group B Streptococcus commonly colonises healthy adults without symptoms, yet under certain circumstances displays the ability to invade host tissues, evade immune detection and cause serious invasive disease...
  19. pmc Comparative genome analysis of Streptococcus infantarius subsp. infantarius CJ18, an African fermented camel milk isolate with adaptations to dairy environment
    Christoph Jans
    Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Schmelzbergstrasse 7, ETH Zurich, Zurich, CH 8092, Switzerland
    BMC Genomics 14:200. 2013
    b>Streptococcus infantarius subsp. infantarius (Sii) belongs to the Streptococcus bovis/Streptococcus equinus complex associated with several human and animal infections...
  20. doi Molecular characterization of a Streptococcus gallolyticus genomic island encoding a pilus involved in endocarditis
    Camille Danne
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, Institut Pasteur, Paris, France
    J Infect Dis 204:1960-70. 2011
    b>Streptococcus gallolyticus is a causative agent of infective endocarditis associated with colon cancer. Genome sequence of strain UCN34 revealed the existence of 3 pilus loci (pil1, pil2, and pil3)...
  21. pmc CpsY influences Streptococcus iniae cell wall adaptations important for neutrophil intracellular survival
    Jonathan P Allen
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Infect Immun 80:1707-15. 2012
    ..regulator previously identified as an important virulence determinant for systemic infection of Streptococcus iniae...
  22. pmc Barriers to genetic exchange between bacterial species: Streptococcus pneumoniae transformation
    J Majewski
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    J Bacteriol 182:1016-23. 2000
    ..Here we demonstrate that sexual isolation in transformation between Streptococcus pneumoniae recipient strains and donor DNA from related strains and species follows the described exponential ..
  23. doi Identification and immunoprotective analysis of a Streptococcus iniae subunit vaccine candidate
    Shuang Cheng
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Vaccine 28:2636-41. 2010
    b>Streptococcus iniae is a Gram-positive bacterium and a severe aquaculture pathogen that can infect a wide range of farmed fish species...
  24. pmc The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae
    Carlo J E Milani
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0687, La Jolla, CA 92093 0687, USA
    Microbiology 156:543-54. 2010
    The aquatic zoonotic pathogen Streptococcus iniae represents a threat to the worldwide aquaculture industry and poses a risk to humans who handle raw fish. Because little is known about the mechanisms of S...
  25. pmc Peptide pheromone signaling in Streptococcus and Enterococcus
    Laura C Cook
    Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL, USA
    FEMS Microbiol Rev 38:473-92. 2014
    ..Here we review pheromone signaling identified in the genera Enterococcus and Streptococcus, providing examples of all four types of pathways.
  26. doi Diversity of human small intestinal Streptococcus and Veillonella populations
    Bartholomeus van den Bogert
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    FEMS Microbiol Ecol 85:376-88. 2013
    Molecular and cultivation approaches were employed to study the phylogenetic richness and temporal dynamics of Streptococcus and Veillonella populations in the small intestine...
  27. doi Epidemiology and pathogenicity of zoonotic streptococci
    Marcus Fulde
    Medizinische Hochschule Honnover Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Carl Neuberg Str 1, 30625 Hannover, Germany
    Curr Top Microbiol Immunol 368:49-81. 2013
    Zoonotic infections caused by Streptococcus spp. have been neglected in spite of the fact that frequency and severity of outbreaks increased dramatically in recent years...
  28. pmc Disease isolates of Streptococcus pseudopneumoniae and non-typeable S. pneumoniae presumptively identified as atypical S. pneumoniae in Spain
    Dora Rolo
    Institut d Investigacio Biomedica de Bellvitge, Hospital Universitari de Bellvitge, Microbiology Department, Universistat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e57047. 2013
    We aimed to obtain insights on the nature of a collection of isolates presumptively identified as atypical Streptococcus pneumoniae recovered from invasive and non-invasive infections in Spain...
  29. pmc Population dynamics of Streptococcus mitis in its natural habitat
    J Hohwy
    Department of Medical Microbiology and Immunology, Faculty of Health Sciences, University of Aarhus, DK-8000 Aarhus C, Denmark
    Infect Immun 69:6055-63. 2001
    The purpose of this study was to examine the genetic structure of the typical commensal Streptococcus mitis biovar 1 in its natural habitat in the human oral cavity and pharynx and to investigate the role that selected microbial ..
  30. pmc Macedocin, a food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198
    Marina D Georgalaki
    Laboratory of Dairy Research, Department of Food Science and Technology, Agricultural University of Athens, Greece
    Appl Environ Microbiol 68:5891-903. 2002
    b>Streptococcus macedonicus ACA-DC 198, a strain isolated from Greek Kasseri cheese, produces a food-grade lantibiotic named macedocin. Macedocin has a molecular mass of 2,794.76 +/- 0.42 Da, as determined by electrospray mass spectrometry...
  31. doi Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study
    J P Burton
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, Dunedin, New Zealand
    Food Chem Toxicol 49:2356-64. 2011
    b>Streptococcus salivarius is naturally a predominant member of the human oropharynx and the commercial probiotic strain K12 has been consumed for more than a decade...
  32. pmc Etiology and antimicrobial susceptibility of udder pathogens from cases of subclinical mastitis in dairy cows in Sweden
    Ylva Persson
    Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SE 75189 Uppsala, Sweden
    Acta Vet Scand 53:36. 2011
    ..The aim was to investigate the microbial panorama and the occurrence of antimicrobial resistance. Moreover, differences between newly infected cows and chronically infected cows were investigated...
  33. pmc Safety assessment of the oral cavity probiotic Streptococcus salivarius K12
    Jeremy P Burton
    BLIS Technologies, Centre for Innovation, University of Otago, P O Box 56, Dunedin, New Zealand
    Appl Environ Microbiol 72:3050-3. 2006
    b>Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S...
  34. pmc Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis
    U Mechold
    Institute for Molecular Biology, Jena University, Germany
    J Bacteriol 178:1401-11. 1996
    We examined the functional attributes of a gene encountered by sequencing the streptokinase gene region of Streptococcus equisimilis H46A. This gene, originally called rel, here termed relS...
  35. doi Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO, and Sb2O3) to Escherichia coli, Bacillus subtilis, and Streptococcus aureus
    Yong Wook Baek
    Department of Environmental Science, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Sci Total Environ 409:1603-8. 2011
    ..microbial toxicities of metal oxide nanoparticles were evaluated for Escherichia coli, Bacillus subtilis, and Streptococcus aureus in laboratory experiments. The nanoparticles tested were CuO, NiO, ZnO, and Sb(2)O(3)...
  36. pmc Highly penicillin-resistant multidrug-resistant pneumococcus-like strains colonizing children in Oeiras, Portugal: genomic characteristics and implications for surveillance
    Alexandra S Simões
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras 2780 156, Portugal
    J Clin Microbiol 48:238-46. 2010
    ..all isolates were classified as "streptococci of the mitis group" that, however, were distinct from typical Streptococcus pneumoniae or Streptococcus mitis. A single isolate was identified as Streptococcus pseudopneumoniae...
  37. pmc Screening for antimicrobial resistance genes and virulence factors via genome sequencing
    Mads Bennedsen
    Innovation, Chr Hansen A S, 10 12 Bøge Allé, DK 2970 Hørsholm, Denmark
    Appl Environ Microbiol 77:2785-7. 2011
    ..No virulence factor genes were detected, while several isolates contained antimicrobial resistance genes...
  38. pmc Bacteriocin diversity in Streptococcus and Enterococcus
    Ingolf F Nes
    Laboratory of Microbial Gene Technology, Norwegian University of Life Sciences, N 1432 As, Norway
    J Bacteriol 189:1189-98. 2007
  39. pmc Incidence and pathogenic effect of Streptococcus pseudopneumoniae
    Colette Harf-Monteil
    Institute of Bacteriology, UPRES EA 3432, Louis Pasteur University, Strasbourg University Hospital, Strasbourg, France
    J Clin Microbiol 44:2240-1. 2006
    We evaluated the incidence of Streptococcus pseudopneumoniae in clinical isolates by phenotypic methods and DNA-DNA hybridization. The pathogenic role of this organism was investigated with the mouse peritonitis/sepsis model...
  40. pmc Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)
    Yumi Shimomura
    Department of Infectious Diseases, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    BMC Genomics 12:17. 2011
    b>Streptococcus dysgalactiae subsp. equisimilis (SDSE) causes invasive streptococcal infections, including streptococcal toxic shock syndrome (STSS), as does Lancefield group A Streptococcus pyogenes (GAS)...
  41. pmc Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1
    Yiqian Dong
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Appl Environ Microbiol 68:5549-53. 2002
    ..To initiate a study of the Streptococcus gordonii ADS, the ADS gene cluster was isolated from subgenomic DNA libraries of S...
  42. ncbi Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A
    A Vojdani
    Section of Neuroimmunology, Immunosciences Laboratory, Inc, 8693 Wilshire Boulevard, Suite 200, Beverly Hills, CA 90211, USA
    J Neuroimmunol 129:168-77. 2002
    ..These results suggest a mechanism by which bacterial infections and milk antigens may modulate autoimmune responses in autism...
  43. ncbi An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets
    Barbara A Bensing
    Division of Infectious Diseases, Veterans Affairs Medical Center 111W and the University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Microbiol 44:1081-94. 2002
    ..However, Streptococcus gordonii strain M99 encodes SecA and SecY homologues that are not required for viability or for the ..
  44. ncbi Antibacterial activity of polyphenol components in oolong tea extract against Streptococcus mutans
    H Sasaki
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    Caries Res 38:2-8. 2004
    ..study was to determine the antibacterial activity of oolong tea extract on oral streptococci, including Streptococcus mutans and Streptococcus sobrinus, and to identify the response to its components...
  45. pmc Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis
    Marisa Haenni
    Unité Antibiorésistance et Virulence Bactériennes, Anses Lyon, 31 avenue Tony Garnier, F 69364 Lyon Cedex 07, France
    Appl Environ Microbiol 76:7957-65. 2010
    Bovine isolates of Streptococcus agalactiae (n = 76), Streptococcus dysgalactiae subsp...
  46. doi Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer
    Annemarie Boleij
    Department of Laboratory Medicine, Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 203:1101-9. 2011
    The prevalence of Streptococcus gallolyticus subsp gallolyticus ( Streptococcus bovis biotype I) endocarditis is in general low but very often linked to colorectal cancer...
  47. pmc Communication among oral bacteria
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    Microbiol Mol Biol Rev 66:486-505, table of contents. 2002
    ..A successful search for genes critical for mixed-species community organization will be accomplished only when it is conducted with mixed-species communities...
  48. doi Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions
    Bertil Kinnby
    Department of Oral Biology, Malmo University, S 20506 Malmö, Sweden
    Microbiology 154:924-31. 2008
    ..The findings illustrate how apparently innocuous commensal bacteria are capable of utilizing a mechanism that is generally regarded as being of importance to pathogenicity and suggest an additional role of plasminogen binding...
  49. ncbi Phylogenetic relationships and genotyping of the genus Streptococcus by sequence determination of the RNase P RNA gene, rnpB
    Jenny Täpp
    Department of Clinical Microbiology, University Hospital, SE 751 85 Uppsala, Sweden
    Int J Syst Evol Microbiol 53:1861-71. 2003
    ..In this study, rnpB was sequenced in 50 type strains and 29 additional strains of the genus Streptococcus. Putative secondary-structure models and possible interactions in RNase P RNA molecules are discussed...
  50. pmc Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and
    Kasey M Moyes
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    BMC Genomics 10:542. 2009
    Information generated via microarrays might uncover interactions between the mammary gland and Streptococcus uberis (S. uberis) that could help identify control measures for the prevention and spread of S...
  51. pmc Extent of horizontal gene transfer in evolution of Streptococci of the salivarius group
    Christine Delorme
    Laboratoire de Genetique Microbienne, Institut National de Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    J Bacteriol 189:1330-41. 2007
    The phylogenetically closely related species Streptococcus salivarius and Streptococcus vestibularis are oral bacteria that are considered commensals, although they can also be found in human infections...
  52. pmc Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence
    Stephen B Beres
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 99:10078-83. 2002
    ..Serotype M3 strains of group A Streptococcus (GAS) are a common cause of severe invasive infections with unusually high rates of morbidity and mortality...
  53. pmc Intra- and interspecies signaling between Streptococcus salivarius and Streptococcus pyogenes mediated by SalA and SalA1 lantibiotic peptides
    M Upton
    Department of Oral and Dental Science, University of Bristol Dental School, Bristol, BS1 2LY, United Kingdom
    J Bacteriol 183:3931-8. 2001
    b>Streptococcus salivarius 20P3 produces a 22-amino-acid residue lantibiotic, designated salivaricin A (SalA), that inhibits the growth of a range of streptococci, including all strains of Streptococcus pyogenes...
  54. pmc Molecular characterization of subject-specific oral microflora during initial colonization of enamel
    Patricia I Diaz
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Dr, Bethesda, MD 20892 4350, USA
    Appl Environ Microbiol 72:2837-48. 2006
    ..In all subjects, however, 4-h and 8-h communities were dominated by Streptococcus spp. belonging to the Streptococcus oralis/Streptococcus mitis group...
  55. pmc Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque
    Robert J Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    J Bacteriol 185:3400-9. 2003
    ..In intrageneric coaggregation, streptococci such as Streptococcus gordonii DL1 recognize receptor polysaccharides (RPS) borne on other streptococci such as Streptococcus oralis ..
  56. pmc Analysis of streptococcal CRISPRs from human saliva reveals substantial sequence diversity within and between subjects over time
    David T Pride
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    Genome Res 21:126-36. 2011
    ....
  57. pmc The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha
    Barbara A Bensing
    Division of Infectious Diseases, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Infect Immun 72:6528-37. 2004
    Platelet binding by Streptococcus gordonii strain M99 is dependent on expression of the cell wall-anchored glycoprotein GspB...
  58. pmc Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges
    L S Havarstein
    Department of Biotechnological Sciences, Agricultural University of Norway, As
    J Bacteriol 179:6589-94. 1997
    To map the incidence of natural competence in the genus Streptococcus, we used PCR to screen a number of streptococcal strains for the presence of the recently identified competence regulation operon, containing the comC, -D, and -E ..
  59. pmc Functions of cell surface-anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors
    Nicholas S Jakubovics
    Department of Oral and Dental Science, University of Bristol, UK
    Infect Immun 73:6629-38. 2005
    b>Streptococcus gordonii colonizes multiple sites within the human oral cavity. This colonization depends upon the initial interactions of streptococcal adhesins with host receptors...
  60. doi Inhibiting effects of Streptococcus salivarius on competence-stimulating peptide-dependent biofilm formation by Streptococcus mutans
    S Tamura
    Dentistry for Persons with Disabilities, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 24:152-61. 2009
    The effects of Streptococcus salivarius on the competence-stimulating peptide (CSP)-dependent biofilm formation by Streptococcus mutans were investigated.
  61. pmc Role of arginine deiminase of Streptococcus cristatus in Porphyromonas gingivalis colonization
    Jie Wu
    Department of Oral Biology, School of Dentistry, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Antimicrob Agents Chemother 54:4694-8. 2010
    ..gingivalis colonization. Here we report that a surface protein, arginine deiminase (ArcA) of Streptococcus cristatus, represses FimA production and inhibits biofilm formation of P. gingivalis...
  62. pmc Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque
    Bing yan Wang
    School of Dentistry, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Clin Microbiol 47:3902-6. 2009
    ..We have shown that Streptococcus cristatus CC5A inhibits expression of fimA, a gene encoding the major protein subunit of long fimbriae in P...
  63. pmc Molecular characterization of cadmium resistance in Streptococcus thermophilus strain 4134: an example of lateral gene transfer
    Jan Schirawski
    National Food Biotechnology Centre, Cork, Ireland
    Appl Environ Microbiol 68:5508-16. 2002
    Two genes (cadC(St) and cadA(St) [subscript St represents Streptococcus thermophilus]), located on the chromosome of S. thermophilus 4134, were shown to constitute a cadmium/zinc resistance cassette...
  64. pmc Carriage of group B streptococcus in pregnant women from Oxford, UK
    N Jones
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Clin Pathol 59:363-6. 2006
    To investigate asymptomatic vagino-rectal carriage of group B streptococcus (GBS) in pregnant women.
  65. pmc Towards control of Streptococcus iniae
    Justice C F Baiano
    The University of Queensland, Aquatic Animal Health Laboratory, Centre for Marine Studies, St Lucia, Queensland 4072, Australia
    Emerg Infect Dis 15:1891-6. 2009
    b>Streptococcus iniae is an emerging zoonotic pathogen; such infections generally occur through injuries associated with preparing whole fresh fish for cooking...
  66. doi A pivotal role for the Streptococcus iniae extracellular polysaccharide in triggering proinflammatory cytokines transcription and inducing death in rainbow trout
    Marina Eyngor
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    FEMS Microbiol Lett 305:109-20. 2010
    b>Streptococcus iniae is a major pathogen of fish, causing considerable economic losses in Israel, the United States and the Far East...
  67. pmc Use of phylogenetic and phenotypic analyses to identify nonhemolytic streptococci isolated from bacteremic patients
    Tomonori Hoshino
    Institute of Medical Microbiology and Immunology, Aarhus University, Bartholin Building, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 43:6073-85. 2005
    ..endocarditis, septicemia, and meningitis and 33 reference strains, including type strains of all relevant Streptococcus species, were examined...
  68. doi A predatory mechanism dramatically increases the efficiency of lateral gene transfer in Streptococcus pneumoniae and related commensal species
    Ola Johnsborg
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, N 1432 As, Norway
    Mol Microbiol 69:245-53. 2008
    ..that are competent for natural genetic transformation, such as pneumococci and their commensal relatives Streptococcus mitis and Streptococcus oralis, take up exogenous DNA and incorporate it into their genomes by homologous ..
  69. doi In vitro and in vivo safety evaluation of the bacteriocin producer Streptococcus macedonicus ACA-DC 198
    Petros A Maragkoudakis
    Department of Food Science and Technology, Agricultural University of Athens, Greece
    Int J Food Microbiol 133:141-7. 2009
    b>Streptococcus macedonicus ACA-DC 198, a bacteriocin producer isolated from Greek Kasseri cheese, was used in a series of in vitro and in vivo experiments in order to evaluate its pathogenic potential...
  70. pmc Inhibition of the NF-kappaB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius
    Ghalia Kaci
    Commensal and Food Bacteria Group, INRA, UMR1319 MICALIS, Domaine de Vilvert, F 78352 Jouy en Josas, France
    Appl Environ Microbiol 77:4681-4. 2011
    b>Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α)...
  71. pmc Heterologous expression of sahH reveals that biofilm formation is autoinducer-2-independent in Streptococcus sanguinis but is associated with an intact activated methionine cycle
    Sylvio Redanz
    Institute of Medical Microbiology, Virology and Hygiene, Rostock University Hospital, 18057 Rostock, Germany
    J Biol Chem 287:36111-22. 2012
    ..sanguinis is not under control of AI-2. Our study suggests that previously evaluated LuxS mutants in other species need to be revisited to resolve the precise contribution of AI-2 substance pools and the methionine pathways...
  72. ncbi The "open" and "closed" structures of the type-C inorganic pyrophosphatases from Bacillus subtilis and Streptococcus gordonii
    S Ahn
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Mol Biol 313:797-811. 2001
    ..Structural studies of the type-C PPases from Streptococcus gordonii and Bacillus subtilis reveal a homodimeric structure, with each polypeptide folding into two domains ..
  73. pmc Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish
    Jeffrey B Locke
    Department of Pediatrics, Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Bacteriol 189:1279-87. 2007
    ..Little is known about virulence mechanisms of the fish pathogen Streptococcus iniae, though indirect evidence suggests that capsule could represent an important factor. The putative S...
  74. pmc Enhanced production, purification, characterization and mechanism of action of salivaricin 9 lantibiotic produced by Streptococcus salivarius NU10
    Abdelahhad Barbour
    Institute of Biological Sciences, Microbiology Division, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e77751. 2013
    ..Salivaricin 9 is a newly discovered lantibiotic produced by Streptococcus salivarius. In this study we present the mechanism of action of salivaricin 9 and some of its properties...
  75. doi A novel multiplex PCR/RFLP assay for the identification of Streptococcus bovis/Streptococcus equinus complex members from dairy microbial communities based on the 16S rRNA gene
    Christoph Jans
    Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland
    FEMS Microbiol Lett 326:144-50. 2012
    The Streptococcus bovis/Streptococcus equinus complex (SBSEC) comprises pathogenic species associated with different degrees with human infections but also spontaneously fermented dairy products...
  76. pmc Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease
    Jeffrey D Fuller
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Infect Immun 70:5730-9. 2002
    b>Streptococcus iniae causes meningoencephalitis and death in cultured fish species and soft-tissue infection in humans. We recently reported that S...
  77. doi Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species
    Nobuo Okahashi
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    FEMS Microbiol Lett 323:164-70. 2011
    b>Streptococcus sanguinis, a normal inhabitant of the human oral cavity, is a common streptococcal species implicated in infective endocarditis. Herein, we investigated the effects of infection with S...
  78. pmc Salivaricin D, a novel intrinsically trypsin-resistant lantibiotic from Streptococcus salivarius 5M6c isolated from a healthy infant
    Dagim Jirata Birri
    Department of Chemistry, Biotechnology and Food Science, Laboratory of Microbial Gene Technology and Food Microbiology, Norwegian University of Life Sciences, As, Norway
    Appl Environ Microbiol 78:402-10. 2012
    In this work, we purified and characterized a newly identified lantibiotic (salivaricin D) from Streptococcus salivarius 5M6c. Salivaricin D is a 34-amino-acid-residue peptide (3,467...
  79. pmc In vitro functional and immunomodulatory properties of the Lactobacillus helveticus MIMLh5-Streptococcus salivarius ST3 association that are relevant to the development of a pharyngeal probiotic product
    Valentina Taverniti
    Department of Food Science and Microbiology, Universita degli Studi di Milano, Milan, Italy
    Appl Environ Microbiol 78:4209-16. 2012
    ..in vitro the functional and immunomodulatory properties of the strains Lactobacillus helveticus MIMLh5 and Streptococcus salivarius ST3 that were selected during previous investigations as promising pharyngeal probiotics...
  80. doi Novel Streptococcus infantarius subsp. infantarius variants harboring lactose metabolism genes homologous to Streptococcus thermophilus
    Christoph Jans
    Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
    Food Microbiol 31:33-42. 2012
    b>Streptococcus infantarius subsp. infantarius belongs to the Streptococcus bovis/Streptococcus equinus complex (SBSEC) commonly associated with human and animal infections. We elucidated the lactose metabolism of S. infantarius subsp...
  81. doi Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis
    A Naeem
    Mammalian NutriPhysioGenomics, and Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Dairy Sci 95:6397-408. 2012
    ..associated with regulation of innate immunity and mammary epithelial cell function in tissue challenged with Streptococcus uberis...
  82. pmc D-alanylation of lipoteichoic acids confers resistance to cationic peptides in group B streptococcus by increasing the cell wall density
    Ron Saar-Dover
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Pathog 8:e1002891. 2012
    ..various functional and biophysical approaches to investigate the interactions of the human pathogen Group B Streptococcus (GBS) with a series of CAMPs having different properties...
  83. pmc Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus
    Wen Zhang
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China
    PLoS ONE 7:e46390. 2012
    ..of T4SS, Type-IVC secretion system and indicate its common existence in the Gram-positive bacterial genus Streptococcus. We further identified that VirB1, VirB4, VirB6 and VirD4 are the minimal key components of this system...
  84. doi Production and purification of a novel exopolysaccharide from lactic acid bacterium Streptococcus phocae PI80 and its functional characteristics activity in vitro
    Paulraj Kanmani
    Department of Biotechnology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
    Bioresour Technol 102:4827-33. 2011
    ..culture conditions which ease the synthesis of a novel exopolysaccharide (EPS) from a potent marine strain Streptococcus phocae was proposed in this study. The strain grows well at 35 °C, pH 7...
  85. doi Construction and comparative study of monovalent and multivalent DNA vaccines against Streptococcus iniae
    Yun Sun
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China
    Fish Shellfish Immunol 33:1303-10. 2012
    b>Streptococcus iniae is an important fish pathogen with a broad host range that includes both marine and freshwater fish species. With an aim to develop effective vaccines against S...
  86. pmc Identification and molecular characterisation of a fibrinogen binding protein from Streptococcus iniae
    Justice C F Baiano
    Aquatic Animal Health Laboratory, Centre for Marine Studies, The University of Queensland, St Lucia, 4072, Australia
    BMC Microbiol 8:67. 2008
    ..iniae, a Lancefield non-typeable pathogen causing devastating fish losses in the aquaculture industry and an opportunistic pathogen of humans, and identifies the proteins involved and their encoding genes...
  87. pmc Complete genome sequence and immunoproteomic analyses of the bacterial fish pathogen Streptococcus parauberis
    Seong Won Nho
    College of Veterinary Medicine, Gyeongsang National University, Gyeongnam 660 701, South Korea
    J Bacteriol 193:3356-66. 2011
    Although Streptococcus parauberis is known as a bacterial pathogen associated with bovine udder mastitis, it has recently become one of the major causative agents of olive flounder (Paralichthys olivaceus) streptococcosis in northeast ..
  88. doi Macedovicin, the second food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198
    Marina Georgalaki
    Laboratory of Dairy Research, Department of Food Science and Technology, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece
    Food Microbiol 33:124-30. 2013
    b>Streptococcus macedonicus ACA-DC 198 was found to produce a second lantibiotic named macedovicin in addition to macedocin. Macedovicin was purified to homogeneity and mass spectrometric analysis identified a peptide of approximately 3...
  89. ncbi The present state of species within the genera Streptococcus and Enterococcus
    Werner Kohler
    Formerly Institute of Experimental Microbiology, Friedrich Schiller University, Jena, Germany
    Int J Med Microbiol 297:133-50. 2007
  90. pmc Competence for natural genetic transformation in the Streptococcus bovis group streptococci S. infantarius and S. macedonicus
    Donald A Morrison
    Deptartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    J Bacteriol 195:2612-20. 2013
    Natural genetic transformation is common among many species of the genus Streptococcus, but it has never, or rarely, been reported for the Streptococcus pyogenes and S...
  91. pmc Role of D-alanylation of Streptococcus gordonii lipoteichoic acid in innate and adaptive immunity
    Karenn G Chan
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia B3H 3J5, Canada
    Infect Immun 75:3033-42. 2007
    In recent years, there has been considerable interest in using the oral commensal gram-positive bacterium Streptococcus gordonii as a live vaccine vector...
  92. pmc Enterococcus and Streptococcus spp. associated with chronic and self-medicated urinary tract infections in Vietnam
    Louise Ladefoged Poulsen
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, Frederiksberg C, Denmark
    BMC Infect Dis 12:320. 2012
    ..Enterococcus faecalis isolates were typed by Multi Locus Sequence Typing (MLST), Pulsed-Field Gel Electrophoresis (PFGE) and antimicrobial susceptibility testing...
  93. pmc Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans
    Y Tsukioka
    Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    J Bacteriol 179:1126-34. 1997
    ..comprises three genes concerned with the biosynthesis of the serotype c-specific polysaccharide antigen in Streptococcus mutans...
  94. pmc Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens
    Claudio Palmieri
    Department of Biomedical Sciences and Public Health, Section of Microbiology, Polytechnic University of Marche, Ancona, Italy
    Antimicrob Agents Chemother 56:4697-702. 2012
    ..In the genus Streptococcus, a mosaic tet gene [tet(O/W/32/O)] was first discovered in Streptococcus suis, an emerging drug-resistant pig ..
  95. pmc Complete genome and transcriptomes of Streptococcus parasanguinis FW213: phylogenic relations and potential virulence mechanisms
    Jianing Geng
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e34769. 2012
    b>Streptococcus parasanguinis, a primary colonizer of the tooth surface, is also an opportunistic pathogen for subacute endocarditis...
  96. ncbi The effect of ingestion of milk supplemented with salivaricin A-producing Streptococcus salivarius on the bacteriocin-like inhibitory activity of streptococcal populations on the tongue
    Karen P Dierksen
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Ecol 59:584-91. 2007
    The colonization efficacies of salivaricin A (SalA)-producing Streptococcus salivarius strains 20P3 and 5 were compared when given in milk to 219 children, using either 2-day or 9-day dosing regimens...
  97. pmc Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial
    K Roos
    Ear, Nose, and Throat Department, Lundby Hospital, 41717 Gothenburg, Sweden
    BMJ 322:210-2. 2001
    ....
  98. pmc Whole-genome sequence of Streptococcus pseudopneumoniae isolate IS7493
    Dea Shahinas
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    J Bacteriol 193:6102-3. 2011
    b>Streptococcus pseudopneumoniae is a member of the viridans group streptococci (VGS) whose pathogenic significance is unclear. We announce the complete genome sequence of S. pseudopneumoniae IS7493...
  99. ncbi Cow- and quarter-level risk factors for Streptococcus uberis and Staphylococcus aureus mastitis
    R N Zadoks
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Dairy Sci 84:2649-63. 2001
    This study was designed to identify risk factors for intramammary infections with Streptococcus uberis and Staphylococcus aureus under field conditions...
  100. pmc Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8
    Ahmed S Abdulamir
    Institute of Bioscience, University Putra Malaysia, Selangor, Malaysia
    Mol Cancer 9:249. 2010
    Colorectal cancer (CRC) has long been associated with bacteremia and/or endocarditis by Streptococcus gallolyticus member bacteria (SGMB) but the direct colonization of SGMB along with its molecular carcinogenic role, if any, has not ..
  101. ncbi A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters
    J P Burton
    BLIS Technologies, Center for Innovation, University of Otago, Dunedin, New Zealand
    J Appl Microbiol 100:754-64. 2006
    To determine whether dosing with bacteriocin-producing Streptococcus salivarius following an antimicrobial mouthwash effects a change in oral malodour parameters and in the composition of the oral microbiota of subjects with halitosis.

Research Grants75

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..contaminated wounds of drug- resistant super bugs like Methicillin-Resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes and Pseudomonas aeruginosa...
  2. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Early in the 1900's, Coley successfully used a mix of heat-killed Streptococcus and Serratia bacteria to treat a variety of sarcomas and other cancers...
  3. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Group A Streptococcus (GAS) employs multiple defense strategies to resist killing by reactive oxygen species (ROS) formed either by reduction of atmospheric oxygen or by phagocytes upon activation of ..
  4. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for about 40 percent of the total ..
  5. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..epidermidis, three isolates each of Escherichia coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida albicans also demonstrate an electricidal effect...
  6. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    ..in 25-30 billion dollars in annual health care costs in the US and is caused by the pathogenic bacterium Streptococcus mutans...
  7. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..In Aim 3, we will establish in vitro bacterial biofilms with nontypeable Haemophilus influenzae (NTHi) or with Streptococcus pneumoniae (pneumococcus) and determine the viral replication potential in immune and epithelial cells exposed ..
  8. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..type b (Hib) vaccine and pneumococcal conjugate vaccine, and the emergence of non-vaccine serotypes of Streptococcus pneumioniae and highly virulent clones of methcillin resistant Staphylococcus aureus (MRSA)...
  9. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..The focus of this proposal is on a clinically important subset of Streptococcus pneumoniae strains (the SP-1) that are pandemic and drug resistant. The aims are to: 1) develop an S...
  10. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..Myx exhibits potent antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and Clostridium difficile in culture...
  11. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..The focus of this proposal is on a clinically important subset of Streptococcus pneumoniae strains (the SP-1) that are pandemic and drug resistant. The aims are to: 1) develop an S...
  12. Delineation of the molecular mechanisms underlying group A Streptococcus virulenc
    Paul Sumby; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The human bacterial pathogen group A Streptococcus (GAS) causes a broad spectrum of diseases, including pharyngitis, impetigo, and necrotizing fasciitis...
  13. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Group B streptococcus (GBS) is currently a leading single cause of neonatal sepsis and the third most frequent over all cause of bacterial meningitis in the United States...
  14. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus pyogenes (Group A strep), vancomycin resistant enterococcus (VRE), Bacillus ..
  15. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..The best-known toxin in this family is the highly modified peptide, streptolysin S (SLS, produced by Streptococcus pyogenes). SLS production is required for the infective process, but not essential life processes...
  16. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..we discovered in the spore-forming bacterium, Bacillus subtilis, but is also found in Staphylococcus aureus, Streptococcus pneumoniae, Listeria monocytogenes, and Bacillus anthracis...
  17. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..protein present in Gram-positive bacteria, including important human pathogens such as Staphylococcus aureus, Streptococcus pneumonia, Clostridium perfringens, Listeria monocytogenes, Bacillus anthracis, etc. PcrA was discovered in S...
  18. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    b>Streptococcus mutans is the primary causative agent of dental caries, which remains the most common chronic disease among children and is untreated in up to 30% of adults over 35 yrs-old...
  19. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..phosphohydrolase domain and regulates the expression of glycolytic enzymes and virulence factors of Streptococcus pyogenes in response to low nutrient conditions...
  20. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is normally found as an inhabitant of the human nasopharynx that becomes pathogenic in response to environmental changes...
  21. GENETICS AND VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    JANET L YOTHER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, resulting in 1 to 2 million deaths annually. Serious infection and death result primarily from the ability of S...
  22. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Group A streptococcus (GAS) causes a particularly severe form of septic shock termed Streptococcal Toxic Shock Syndrome (StrepTSS) and mortalities range from 30-70% despite modern medical practices...
  23. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..b>Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood OM...
  24. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..coli, Vibrio) as well as the active bacterial core surveillance project (Streptococcus pneumoniae, N. meningitidis, Listeria monocytogenes, Haemophilus influenzae). We are requesting funding for a ...
  25. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..new materials and to injection mold TTs, 2) to confirm our in vitro studies with Haemophilus influenzae and Streptococcus pneumoniae, and quantify synergy and monitor for the development of resistant strains, 3) to assess ..
  26. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    ..Based on the findings of group A Streptococcus (GAS) ESTK and ESTP that we recently characterized, we hypothesize that enterococcal efSTK and efSTP have ..
  27. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumonias resulting from failure to eradicate bacterial (Streptococcus pneumonia, Haemophilus influenza, Staphylococcus aureus, Pseudomonas aeruginosa) and viral (rhinovirus, influenza virus) ..
  28. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ..VHH using three different mouse model systems and two different bacterial strains, one of which, Streptococcus gordonii, is selected specifically for the purpose of demonstrating proof of principle in mouse model systems ..
  29. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..human rhinovirus A/B/C, human bocavirus 1/2/3/4, human parainfluenza virus 1/2/3/4, Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis...
  30. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..psrP-secY2A2 is a 37-kb pathogenicity island whose presence has been positively correlated with the ability of Streptococcus pneumoniae to cause human disease...
  31. Dissecting the Function and Regulation of Stress-Induced SUMOylation
    ROBERT CHARLES AUGUSTINE; Fiscal Year: 2013
    ..In addition, several pathogenic bacteria (Listeria monocytogenes, Streptococcus pneumoniae) and viruses (human adenovirus, influenza virus) alter SIS, and this is important for bypassing ..
  32. Expression of clp genes in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is considered as the major etiological agent in dental caries. S. mutans is also an important agent of infective endocarditis...
  33. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    ..Since the recent licensure of a 7-valent vaccine directed against Streptococcus pneumoniae, the relative proportion of cases of OM due to our studied microorganism (nontypeable Haemophilus ..
  34. GAS Switch from Colonizing Bacterium to Invasive Pathogen
    Victor Nizet; Fiscal Year: 2012
    ..Project Narrative Group A Streptococcus (GAS) is a bacteria that is a leading cause of infections in humans of all ages, from simple [unreadable]strep ..
  35. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis and is strongly associated with cardiovascular disease and stroke...
  36. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..any other unanticipated genome rearrangements will be used in studies of the infectious agents Vibrio cholera, Streptococcus pneumoniae and Legionella pneumophila...
  37. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    Project summary: Streptococcus mutans is the primary cariogen that produces several virulence factors. The long-term goal of the proposed studies is to characterize specific interactions of S...
  38. Inhibition of lung defense by air pollutant particulates
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..the effect on mice inhaling vanadium and then infected with airway pathogens that cause pneumonia, such as Streptococcus zooepidemicus and Staphylococcus aureus...
  39. New composite material design based on studies of tooth-composite and microbial i
    J Paul Santerre; Fiscal Year: 2013
    ..Objective: To establish methods for reproducibly measuring gene expression of Streptococcus mutans and Lactobacillus casei in situ after formation of biofilms on resin composite, along the resin-dentin ..
  40. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans-induced caries formation continues to be a major problem in developed and developing nations which, according to the World Health Organization, impacts 60-90% of children world-..
  41. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..b>Streptococcus pneumoniae not only is the major bacterial cause of otitis media but also causes additional life-threatening ..
  42. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..clinically important microorganisms, including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae...
  43. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is still a major cause of morbidity and mortality around the world and its most common clonotypes are resistant to most first line antibiotics...
  44. REGULATION OF LIPID METABOLISM IN BACTERIA
    Charles O Rock; Fiscal Year: 2013
    ..fatty acid and phospholipid synthesis in two important human pathogens: Staphylococcus aureus and Streptococcus pneumoniae...
  45. Functional Amyloid Formation in Streptococcus mutans
    L Jeannine Brady; Fiscal Year: 2013
    ..caries is the most common infectious disease in the world caused in large part by the Gram-positive bacterium Streptococcus mutans...
  46. Studies of YlxM of Streptococcus mutans, a newly identified component of the Sign
    MATTHEW LAWRENCE WILLIAMS; Fiscal Year: 2013
    ..b>Streptococcus mutans is a cariogenic oral pathogen whose virulence is determined in large part by its membrane composition...
  47. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ..studies have reported the presence of antibiotic resistant Pseudomonas aerugenosa, Hemophilus influenza, Streptococcus pneumoniae and Staphylococcus aureus biofilms in the sinuses of cure resistant CRS...
  48. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Data from clinical and basic research have implicated Streptococcus mutans as the primary microbial etiologic agent of dental caries, one of the most common infectious diseases afflicting humans...
  49. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    Abstract: Streptococcus mutans-induced caries formation continues to be a major problem in developed and developing nations which, according to the World Health Organization, impacts 60-90% of children world-wide (123)...
  50. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..TLR-1, -2, and -4 protein levels in the lungs of aged mice versus young mice;2) aged mice infected with Streptococcus pneumoniae develop fulminate pneumonia and die within 36 hours whereas young mice remain relatively healthy;3) ..
  51. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..During the recent flu pandemic, Streptococcus pyogenes caused about 1/3 of the known cases of superinfection...
  52. Coordinate regulation of competence and pneumocin production in S. pneumoniae
    SUZANNE RACHEL DAWID; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (pneumococcus) is an important human pathogen and the most common cause of bacterial meningitis, pneumonia and otitis media...
  53. Cytokine-stimulated systemic defenses during pneumococcal pneumonia
    Joseph P Mizgerd; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (pneumococcus) is the most common cause of community-acquired pneumonia...
  54. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..aureus for the anterior nares niche have focused on individual species, e.g. Staphylococcus epidermidis, Streptococcus pneumoniae, Corynebacterium spp., isolated from culture...
  55. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is a Gram-positive bacterium that can express more than 90 different capsule types (serotypes) and is often carried as a commensal in the human nasopharynx (NPX), but can ..
  56. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..This study will attempt to determine how a common infectious organism, Group A Streptococcus, can alter an individual's propensity to develop type I diabetes (T1D)...
  57. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..The bacteria Streptococcus pneumoniae (SPn) have become one of the most frequent causes of pneumonia, bacteremia, and meningitis in the ..
  58. Bacteriophage Control of DNA Repair in Streptococcus Pyogenes
    WILLIAM MICHAEL MCSHAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The group A streptococcus (GAS;Streptococcus pyogenes) is a major bacterial pathogen of humans, globally causing over 700,000,000 infections and more than 500,000 deaths each year...
  59. Rapid, automated, detection of viral and bacterial pathogens causing meningitis
    Andrew Hemmert; Fiscal Year: 2013
    ..monocytogenes, Mycoplasma pneumoniae, N. meningitidis, P. aeruginosa, Staphylococci species, S. aureus, Streptococcus species, S. agalactiae, S. pneumoniae, S...
  60. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..The mutans streptococcal group, represented by Streptococcus mutans and S. sobrinis, are the major causative agents of dental caries...
  61. Mechanisms of pneumococcal persistence during carriage.
    JEFFREY NEAL WEISER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (the pneumococus) ranks among the five leading causes of infectious death worldwide...
  62. Statins protect against adverse cardiac events during pneumonia
    Carlos J Orihuela; Fiscal Year: 2012
    ..b>Streptococcus pneumoniae (the pneumococcus) is the leading cause of CAP and infectious-related death among the elderly (>..
  63. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the use of antibiotics and vaccines, Streptococcus pneumoniae (pneumococcus) remains a leading cause of community acquired pneumonia and mortality...
  64. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..among otitis prone (OP) children to infections caused by nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (Spn)...
  65. MECHANISMS INVOLVED IN FLAVIN-LINKED OXYGEN METABOLISM
    Al Claiborne; Fiscal Year: 2005
    ..of this group: (1) NADH oxidase (Nox; 2NADH + O2 to 2NAD+ + 2H2O) from the severe human pathogen Streptococcus pyogenes, (2) NADH peroxidase (Npx; NADH + H2O2 - to NAD+ + 2H2O) from Enterococcus faecalis, and (3) alpha-..
  66. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    ..microbial species together with a limited number of acid- producing (cariogenic) bacteria such as Streptococcus mutans and Lactobacillus species...
  67. Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniae
    David S Stephens; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The basis for the emergence of mefE-associated macrolide resistance in Streptococcus pneumoniae is a genetic element, mega (macrolide efflux genetic assembly)...
  68. Development of targeted photodynamic therapy for treatment of dental caries
    Randal Eckert; Fiscal Year: 2010
    ..together with a limited number of pathogenic bacteria, including the major etiological agent of dental caries, Streptococcus mutans, which ferments dietary sugars to produce enamel-damaging organic acids. The eradication of S...
  69. REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITY
    Suzanne Michalek; Fiscal Year: 2003
    ..g., teeth. Secretory IgA antibodies in saliva are important in protection against oral diseases, including Streptococcus mutans-induced dental caries, and are induced following stimulation of the common mucosal immune system (CMIS)...
  70. CLONING AND PURIFICATION OF A VEILLONELLA ADHESIN
    Christopher Hughes; Fiscal Year: 1993
    ..Veillonella, Prevotella, Actinomyces and Streptococcus utilize similar mechanisms to adhere to common streptococcal coaggregation partners...
  71. Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
    Cynthia Stauffacher; Fiscal Year: 2007
    ..It has recently been shown that a number of common human pathogens, including Enterococcus faecalis, Streptococcus pneumoniae and Staphylococcus aureus are dependent on enzymes in the mevalonate pathway for biosynthesis of ..
  72. MtaR-regulated virulence in Streptococcus agalactiae
    Daniel Shelver; Fiscal Year: 2009
    DESCRIPTION (provided by applicant). Streptococcus agalactiae (group B Streptococcus;GBS) is a leading cause of invasive infections such as pneumonia, sepsis, and meningitis in neonates...
  73. 3rd ASM Conference on Cell-Cell Communication in Bacteria
    WILLIAM FUQUA; Fiscal Year: 2007
    ..might communicate with each other via chemical signals, specifically in regulating genetic competence in Streptococcus pneumoniae and in controlling bioluminescence in Vibrio fischeri, respectively...
  74. Duration of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus
    Jessica L Illuzzi; Fiscal Year: 2010
    Vertical transmission of group B streptococcus (GBS) from colonized mothers to their newborns can be attenuated by intrapartum antibiotic prophylaxis...
  75. Heme Acquisition in Group A Streptococcus
    Benfang Lei; Fiscal Year: 2005
    Hemolytic Streptococcus pyogenes, commonly referred as Group A Streptococcus (GAS), is an important human pathogen causing pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, toxic shock syndrome, acute rheumatic fever, ..