yersinia pseudotuberculosis

Summary

Summary: A human and animal pathogen causing mesenteric lymphadenitis, diarrhea, and bacteremia.

Top Publications

  1. ncbi Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: new insights into two-component system regulon plasticity in bacteria
    Claire Flamez
    Inserm U801, Université Lille II Faculté de Médecine Henri Warembourg, Institut Pasteur de Lille, Lille, France
    Int J Med Microbiol 298:193-207. 2008
  2. ncbi The response regulator PhoP negatively regulates Yersinia pseudotuberculosis and Yersinia pestis biofilms
    Yi Cheng Sun
    Department of Cell and Tissue Biology, Program in Microbial Pathogenesis, University of California, San Francisco, CA, USA
    FEMS Microbiol Lett 290:85-90. 2009
  3. ncbi Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins
    Ann Catrin Björnfot
    Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umea University, Umea, Sweden
    J Bacteriol 191:4259-67. 2009
  4. ncbi Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis
    YangBo Hu
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Microbiology 155:3622-31. 2009
  5. ncbi Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA
    Steve Atkinson
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Mol Microbiol 69:137-51. 2008
  6. ncbi The small RNA chaperone Hfq is required for the virulence of Yersinia pseudotuberculosis
    Chelsea A Schiano
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Infect Immun 78:2034-44. 2010
  7. ncbi A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM
    Ann Kathrin Heroven
    Institut fur Mikrobiologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Mol Microbiol 68:1179-95. 2008
  8. ncbi Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
  9. ncbi Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA, a transcriptional activator of the SlyA/Hor family
    G Nagel
    Department of Microbiology, Institute of Microbiology and Plant Physiology, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 41:1249-69. 2001
  10. ncbi Crystal structure of invasin: a bacterial integrin-binding protein
    Z A Hamburger
    Division of Biology 156 29, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Science 286:291-5. 1999

Research Grants

  1. Role of the Y. pseudotuberculosis YscF protein in toxin delivery into host cells
    Alison Davis; Fiscal Year: 2007
  2. MHC AND GAMMA/DELTA T CELL RECOGNITION
    Yueh Hsiu Chien; Fiscal Year: 2002
  3. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
  4. YERSINIA PTPASE INHIBITORS AS ANTI-PLAGUE AGENTS
    Zhong Yin Zhang; Fiscal Year: 2003
  5. MECHANISMS OF BIOSYNTHETIC FORMATION OF DEOXY SUGARS
    Hung wen Liu; Fiscal Year: 2007
  6. INVASION FACTORS OF YERSINIA ENTEROCOLITICA
    VIRGINIA MILLER; Fiscal Year: 2001
  7. Cross-Protective Vaccines Against Emerging Infectious Agents
    MICHAEL MAHAN; Fiscal Year: 2007
  8. Novel Therapeutics for Biodefense
    S Ken Tanaka; Fiscal Year: 2005
  9. Modular Subunit Vaccine for Salmonella
    MARC JENKINS; Fiscal Year: 2007
  10. Cellular analysis of the Yersinia protein kinase A
    Kurt Schesser; Fiscal Year: 2007

Detail Information

Publications243 found, 100 shown here

  1. ncbi Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: new insights into two-component system regulon plasticity in bacteria
    Claire Flamez
    Inserm U801, Université Lille II Faculté de Médecine Henri Warembourg, Institut Pasteur de Lille, Lille, France
    Int J Med Microbiol 298:193-207. 2008
    ..On the basis of genome-wide in silico analysis, the Gram-negative enteropathogenic bacterium Yersinia pseudotuberculosis is thought to encode 24 complete 2CSs...
  2. ncbi The response regulator PhoP negatively regulates Yersinia pseudotuberculosis and Yersinia pestis biofilms
    Yi Cheng Sun
    Department of Cell and Tissue Biology, Program in Microbial Pathogenesis, University of California, San Francisco, CA, USA
    FEMS Microbiol Lett 290:85-90. 2009
    A few Yersinia pseudotuberculosis strains form biofilms on the head of the nematode Caenorhabditis elegans, but numerous others do not. We show that a widely used Y...
  3. ncbi Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins
    Ann Catrin Björnfot
    Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umea University, Umea, Sweden
    J Bacteriol 191:4259-67. 2009
    ..The N263A mutant was cytotoxic for HeLa cells, demonstrating that the T3SS-mediated delivery of effectors was functional. We suggest that YscU blocks Yop release and that autoproteolysis is required to relieve this block...
  4. ncbi Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis
    YangBo Hu
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Microbiology 155:3622-31. 2009
    ..Here we report the positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis. A sigma(70)-dependent promoter was identified by primer extension analysis and an active region with ..
  5. ncbi Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA
    Steve Atkinson
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Mol Microbiol 69:137-51. 2008
    Quorum sensing (QS) in Yersinia pseudotuberculosis involves two pairs of LuxRI orthologues (YpsRI and YtbRI) and multiple N-acylhomoserine lactones (AHLs)...
  6. ncbi The small RNA chaperone Hfq is required for the virulence of Yersinia pseudotuberculosis
    Chelsea A Schiano
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Infect Immun 78:2034-44. 2010
    ..The enteric pathogen Yersinia pseudotuberculosis causes the disease yersiniosis. Here we show that Hfq is required by Y...
  7. ncbi A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM
    Ann Kathrin Heroven
    Institut fur Mikrobiologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Mol Microbiol 68:1179-95. 2008
    The MarR-type regulator RovA controls expression of virulence genes of Yersinia pseudotuberculosis in response to environmental signals...
  8. ncbi Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    ....
  9. ncbi Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA, a transcriptional activator of the SlyA/Hor family
    G Nagel
    Department of Microbiology, Institute of Microbiology and Plant Physiology, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 41:1249-69. 2001
    Invasin is the primary invasive factor of Yersinia pseudotuberculosis that allows efficient internalization into eukaryotic cells...
  10. ncbi Crystal structure of invasin: a bacterial integrin-binding protein
    Z A Hamburger
    Division of Biology 156 29, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Science 286:291-5. 1999
    The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2...
  11. ncbi YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane
    A Holmstrom
    Department of Microbiology, National Defence Research Establishment, Umea, Sweden
    Mol Microbiol 24:73-91. 1997
    ..1996b). We have previously shown that YopK of Yersinia pseudotuberculosis is required for the development of a systemic infection in mice...
  12. ncbi Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis
    R Dessein
    INSERM, U801, Universite de Lille 2, Institut Pasteur de Lille, Lille, France
    Gut 58:771-6. 2009
    b>Yersinia pseudotuberculosis causes ileitis and mesenteric lymphadenitis by mainly invading the Peyer's patches that are positioned in the terminal ileum...
  13. ncbi Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein
    J M Leong
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111
    EMBO J 9:1979-89. 1990
    The invasin protein of the pathogenic Yersinia pseudotuberculosis mediates entry of the bacterium into cultured mammalian cells by binding several beta 1 chain integrins...
  14. ncbi A putative DNA adenine methyltransferase is involved in Yersinia pseudotuberculosis pathogenicity
    Flavie Pouillot
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 153:2426-34. 2007
    ..pestis by a horizontally acquired region which potentially encodes another methyltransferase. YamA might thus be dispensable for Y. pestis growth and virulence because this species has acquired another gene fulfilling the same functions...
  15. ncbi Comparative analysis of type III effector translocation by Yersinia pseudotuberculosis expressing native LcrV or PcrV from Pseudomonas aeruginosa
    Jeanette E Bröms
    Department of Molecular Biology, Umea University, Umea, Sweden
    J Infect Dis 188:239-49. 2003
    ..Thus, a PcrV complex with native P. aeruginosa translocon components is required to form fully functional pores for complete complementation of effector translocation in Yersinia...
  16. ncbi Defective innate cell response and lymph node infiltration specify Yersinia pestis infection
    Françoise Guinet
    Unité des Yersinia, Institut Pasteur, Paris, France
    PLoS ONE 3:e1688. 2008
    Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence...
  17. ncbi Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis
    Olivia L Champion
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
    Microbiology 155:1516-22. 2009
    ..larvae of the wax moth (Galleria mellonella) are susceptible to infection with the human enteropathogen Yersinia pseudotuberculosis at 37 degrees C...
  18. ncbi Loss of a biofilm-inhibiting glycosyl hydrolase during the emergence of Yersinia pestis
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 190:8163-70. 2008
    ..The closely related Yersinia pseudotuberculosis, from which Y...
  19. ncbi Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia
    Markus K Dahlgren
    Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    J Med Chem 50:6177-88. 2007
    ..A PLS discriminant analysis (PLS-DA) model was derived using the same descriptor set as that for the Hi-PLS model. Both models were validated with an external test set...
  20. ncbi Cell invasion and IL-8 production pathways initiated by YadA of Yersinia pseudotuberculosis require common signalling molecules (FAK, c-Src, Ras) and distinct cell factors
    Julia Eitel
    Junior Research Group 6, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Cell Microbiol 7:63-77. 2005
    The YadA protein of Yersinia pseudotuberculosis promotes tight adhesion and invasion into mammalian cells through beta(1)-integrins...
  21. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
    ..The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve...
  22. ncbi OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis
    YangBo Hu
    Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, PR China
    Microbiology 155:2522-31. 2009
    b>Yersinia pseudotuberculosis is an enteric bacterium which must overcome the acidic stress in host organs for successful colonization, but how this bacterium survives in acidic conditions remains largely unknown...
  23. ncbi Exoenzyme T of Pseudomonas aeruginosa elicits cytotoxicity without interfering with Ras signal transduction
    C Sundin
    Department of Microbiology, FOI NBC-Defence, , Sweden
    Cell Microbiol 3:237-46. 2001
    ..a strategy by which ExoT was delivered into host cells by the heterologous type III secretion system of Yersinia pseudotuberculosis. ExoT was found to induce a rounded cell morphology and to mediate disruption of actin microfilaments, ..
  24. ncbi Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae
    Yvonne Göpel
    Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, 37077 Gottingen, Germany
    Nucleic Acids Res 39:1294-309. 2011
    ..Here, we analyzed the transcriptional regulation of glmY/glmZ from Yersinia pseudotuberculosis, Salmonella typhimurium and Escherichia coli, as representatives for other enterobacterial species, ..
  25. ncbi Adaptation of enteropathogenic Yersinia to low growth temperature
    Eveliina Palonen
    Department of Food and Environmental Hygiene, University of Helsinki, Finland
    Crit Rev Microbiol 36:54-67. 2010
    Yersinia enterocolitica and Yersinia pseudotuberculosis are important foodborne pathogens that cause infections through contaminated refrigerated food. Their cold tolerance mechanisms are therefore of special interest...
  26. ncbi The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae
    Stewart J Hinchliffe
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Microbiology 154:1117-31. 2008
    ..Phenotypic assays on defined mutants confirmed a role for the phosphorelay in these processes in both Y. pseudotuberculosis and Y. enterocolitica...
  27. ncbi The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
    I Bolin
    Department of Cell Biology and Microbiology, National Defence Research Institute, Umea, Sweden
    Mol Microbiol 2:237-45. 1988
    The basic Yop2b protein, encoded by the virulence plasmid pIBI of Yersinia pseudotuberculosis, is produced under Ca2+-deficient conditions...
  28. ncbi An outbreak of gastrointestinal illness and erythema nodosum from grated carrots contaminated with Yersinia pseudotuberculosis
    Katri Jalava
    Department of Infectious Diseases Epidemiology, National Public Health Institute, FIN-00300 Helsinki, Finland
    J Infect Dis 194:1209-16. 2006
    BACKGROUND: Outbreaks of Yersinia pseudotuberculosis infection have been epidemiologically linked to fresh produce, but the bacterium has not been recovered from the food items implicated...
  29. ncbi [Elaboration of new adjuvant lipid-saponin complex and its use at experimental immunization by bacterial antigen]
    N M Sanina
    Biomed Khim 53:297-306. 2007
    ..Thus, it's shown the prospect of the use of TI-complexes as a new type of adjuvant carriers for antigens...
  30. ncbi Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase
    Frank Uliczka
    Institut fur Mikrobiologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Cell Microbiol 11:1782-801. 2009
    The outer membrane proteins YadA and invasin of Yersinia pseudotuberculosis promote invasion into mammalian cells through beta(1)-integrins and trigger the production of interleukin (IL)-8...
  31. ncbi Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model
    Lynne K Garrity-Ryan
    Paratek Pharmaceuticals, Inc, Boston, MA 02111, USA
    Infect Immun 78:4683-90. 2010
    ..b>Yersinia pseudotuberculosis lcrF-null mutants showed attenuated virulence in tissue culture and animal models of infection...
  32. ncbi Extracytoplasmic-stress-responsive pathways modulate type III secretion in Yersinia pseudotuberculosis
    Katrin E Carlsson
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Infect Immun 75:3913-24. 2007
    ..Herein, we investigated whether any of these regulatory pathways in the enteropathogen Yersinia pseudotuberculosis affect the functionality of the Ysc-Yop type III secretion system...
  33. ncbi Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages
    Yue Zhang
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, SUNY Stony Brook, Stony Brook, New York 11794 5222, USA
    Infect Immun 76:4299-310. 2008
    b>Yersinia pseudotuberculosis uses a plasmid (pYV)-encoded type III secretion system (T3SS) to translocate a set of effectors called Yops into infected host cells...
  34. ncbi The membrane localization domain is required for intracellular localization and autoregulation of YopE in Yersinia pseudotuberculosis
    Elin L Isaksson
    Department of Molecular Biology, Laboratory of Molecular Infectious Medicine, Umea University, S 90187 Umea, Sweden
    Infect Immun 77:4740-9. 2009
    Recent work has shown that a domain of YopE of Yersinia pseudotuberculosis ranging from amino acids 54 to 75 (R. Krall, Y. Zhang, and J. T. Barbieri, J. Biol. Chem...
  35. ncbi The importance of the small RNA chaperone Hfq for growth of epidemic Yersinia pestis, but not Yersinia pseudotuberculosis, with implications for plague biology
    Guangchun Bai
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    J Bacteriol 192:4239-45. 2010
    Yersinia pestis, the etiologic agent of plague, has only recently evolved from Yersinia pseudotuberculosis. hfq deletion caused severe growth restriction at 37 degrees C in Y. pestis but not in Y. pseudotuberculosis...
  36. ncbi Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia
    Markus K Dahlgren
    Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    Bioorg Med Chem 18:2686-703. 2010
    ..salicylidene acylhydrazides as inhibitors of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. SMD and subsequent synthesis furnished 50 salicylidene acylhydrazides in high purity...
  37. ncbi [Virulence of Yersinia pseudotuberculosis strains isolated from environment as a threat to human epidemic]
    Izabela Czyzewska

    Przegl Epidemiol 57:263-70. 2003
    The purpose of the work has been to identify Yersinia pseudotuberculosis strains and to demonstrate their potential pathogenicity using PCR reaction...
  38. ncbi N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
    Edwin A Yates
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Infect Immun 70:5635-46. 2002
    In gram-negative bacterial pathogens, such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis, cell-to-cell communication via the N-acylhomoserine lactone (AHL) signal molecules is involved in the cell population density-dependent ..
  39. ncbi Th1-type immune response to infection by pYV-cured phoP-phoQ null mutant of Yersinia pseudotuberculosis is defective in mouse model
    Subodh Kumar
    Division of Microbiology, Defence R and D Establishment, Jhansi Road, Gwalior, 474 002, India
    Antonie Van Leeuwenhoek 95:91-100. 2009
    The PhoP-PhoQ two-component system of Yersinia pseudotuberculosis, a Gram-negative enteric pathogen which causes a variety of gastrointestinal and extraintestinal infections in humans, has been shown to be necessary for virulence...
  40. ncbi Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis
    Dana E Harmon
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Antimicrob Agents Chemother 54:3241-54. 2010
    ..b>Yersinia pseudotuberculosis requires the translocation of a group of effector molecules, called Yops, to subvert the innate immune ..
  41. ncbi Influence of the Cpx extracytoplasmic-stress-responsive pathway on Yersinia sp.-eukaryotic cell contact
    Katrin E Carlsson
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Infect Immun 75:4386-99. 2007
    ..This is true of the Yersinia pseudotuberculosis Ysc-Yop type III secretion system...
  42. ncbi A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH
    M Rimpiläinen
    Department of Cell and Molecular Biology, University of Umea, Sweden
    J Bacteriol 174:3355-63. 1992
    ..51. Overexpression of LcrQ in trans in wild-type Yersinia pseudotuberculosis YPIII(pIB102) changed the phenotype from calcium dependence to calcium independence and inhibited Yop ..
  43. ncbi Serotype differences and lack of biofilm formation characterize Yersinia pseudotuberculosis infection of the Xenopsylla cheopis flea vector of Yersinia pestis
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, 903 South 4th St, Hamilton, MT 59840, USA
    J Bacteriol 188:1113-9. 2006
    ..The enteropathogen Yersinia pseudotuberculosis, from which Y. pestis recently evolved, is not transmitted by fleas. However, both Y. pestis and Y...
  44. ncbi Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole-linear ion trap mass spectrometry
    Catharine A Ortori
    Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
    Anal Bioanal Chem 387:497-511. 2007
    ..This LC-MS technique was applied to determine the relative molar ratios of AHLs produced by Yersinia pseudotuberculosis and the consequences of inactivating by mutation either or both of the AHL synthase genes (ypsI and ..
  45. ncbi The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium
    T Bergman
    Department of Cell and Molecular Biology, University of Umea, Sweden
    J Bacteriol 176:2619-26. 1994
    ..These findings indicate that the genes originated from a common ancestor...
  46. ncbi Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB protein
    Michelle B Ryndak
    Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, 130 Life Sciences, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA
    Infect Immun 73:2433-43. 2005
    ..b>Yersinia pseudotuberculosis strains expressing the mutant YopB proteins were used to infect macrophages or epithelial cells...
  47. ncbi Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells
    Alison J Davis
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    J Bacteriol 189:83-97. 2007
    ..Furthermore, the identification of YscF residues that are required for the assembly of the translocon and/or productive interactions with the translocon has allowed us to initiate the mapping of the needle-translocon interface...
  48. ncbi Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1
    Olivia L Champion
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter EX4 4QD, UK
    Microbiology 157:1115-22. 2011
    ..In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation...
  49. ncbi Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides
    Anna M Kauppi
    Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Bioorg Med Chem 15:6994-7011. 2007
    ..Based on the data multivariate QSAR models were established and the final Hi-PLS model showed good correlation between experimentally determined % inhibition and the calculated % inhibition of the reporter-gene signal...
  50. ncbi Yersinia pseudotuberculosis causing a large outbreak associated with carrots in Finland, 2006
    R Rimhanen-Finne
    Department of Infectious Disease Epidemiology, National Public Health Institute, Helsinki, Finland
    Epidemiol Infect 137:342-7. 2009
    A large outbreak of Yersinia pseudotuberculosis O:1 infection affected over 400 children from 23 schools and 5 day-care centres in two municipalities in southern Finland in August-September, 2006...
  51. ncbi Functional characterization of FlgM in the regulation of flagellar synthesis and motility in Yersinia pseudotuberculosis
    LiSha Ding
    Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, China
    Microbiology 155:1890-900. 2009
    We describe here the functional characterization of the flgM gene in Yersinia pseudotuberculosis. Direct interaction of FlgM with the alternative sigma factor sigma(28) (FliA) was first confirmed...
  52. ncbi The flhDC gene affects motility and biofilm formation in Yersinia pseudotuberculosis
    Yao Wang
    Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China
    Sci China C Life Sci 50:814-21. 2007
    The flagella master regulatory gene flhDC of Yersinia pseudotuberculosis serotype III (YPIII) was mutated by deleting the middle region and replaced by a tetracycline resistant gene, and the subsequent mutant strain named YPIIIDeltaflhDC ..
  53. ncbi Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in mice
    A Holmstrom
    Department of Microbiology, National Defense Research Establishment, Umea, Sweden
    Infect Immun 63:2269-76. 1995
    ..Here, we identify and characterize a novel plasmid-encoded virulence determinant of Yersinia pseudotuberculosis, YopK...
  54. ncbi Yersinia pseudotuberculosis-induced calcium signaling in neutrophils is blocked by the virulence effector YopH
    K Andersson
    Division of Medical Microbiology, Department of Health and Environment, Linkoping University, SE 581 85 Linkoping, Sweden
    Infect Immun 67:2567-74. 1999
    ..In this study we investigated the effect of Yersinia pseudotuberculosis on Ca2+ signaling in polymorphonuclear neutrophils...
  55. ncbi Urease is not involved in the virulence of Yersinia pseudotuberculosis in mice
    B Riot
    INSERM U411, Faculte de Medecine Necker, Paris, France
    Infect Immun 65:1985-90. 1997
    A chromosomal locus (ure) involved in the production of urease activity in the bacterial pathogen Yersinia pseudotuberculosis was characterized. The genetic organization of the Y...
  56. ncbi Regulation of Yersinia Yop-effector delivery by translocated YopE
    Margareta Aili
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    Int J Med Microbiol 298:183-92. 2008
    The bacterial pathogen Yersinia pseudotuberculosis uses a type III secretion (T3S) system to translocate Yop effectors into eukaryotic cells...
  57. ncbi RovM, a novel LysR-type regulator of the virulence activator gene rovA, controls cell invasion, virulence and motility of Yersinia pseudotuberculosis
    Ann Kathrin Heroven
    , , 38106 Braunschweig, Germany
    Mol Microbiol 62:1469-83. 2006
    ..of rovA, the expression of the primary invasive factor invasin and other virulence genes of Yersinia pseudotuberculosis in response to environmental signals...
  58. ncbi Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis
    P S G Chain
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 101:13826-31. 2004
    ..causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and ..
  59. ncbi Excision of the high-pathogenicity island of Yersinia pseudotuberculosis requires the combined actions of its cognate integrase and Hef, a new recombination directionality factor
    Biliana Lesic
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 52:1337-48. 2004
    ..The HPI of Yersinia pseudotuberculosis I has previously been shown to be able to excise precisely from the bacterial chromosome by ..
  60. ncbi The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed
    Julia Eitel
    Department of Microbiology, Institute of Microbiology and Plant Physiology, Freie Universitat Berlin, 14195 Berlin, Germany
    Infect Immun 70:4880-91. 2002
    The YadA protein is a major adhesin of Yersinia pseudotuberculosis that promotes tight adhesion to mammalian cells by binding to extracellular matrix proteins...
  61. ncbi Acute oral toxicity of Yersinia pseudotuberculosis to fleas: implications for the evolution of vector-borne transmission of plague
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, MT 59840, USA
    Cell Microbiol 9:2658-66. 2007
    Yersinia pestis diverged from Yersinia pseudotuberculosis</= 20 000 years ago, during which time it evolved to be transmitted by fleas...
  62. ncbi Expression and insecticidal activity of Yersinia pseudotuberculosis and Photorhabdus luminescens toxin complex proteins
    Vitor B Pinheiro
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Cell Microbiol 9:2372-80. 2007
    ..In particular, tc gene homologues have been identified in Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis and may have a role in Y. pestis evolution. Y...
  63. ncbi CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
    C Pourcel
    GPMS, , , 91405 Orsay Cedex, France
    Microbiology 151:653-63. 2005
    ..In nine strains of Yersinia pseudotuberculosis, 132 spacers were found, of which only three are common to Y. pestis isolates. In Y...
  64. ncbi The Yersinia pseudotuberculosis and Yersinia pestis toxin complex is active against cultured mammalian cells
    Michelle C Hares
    University of Bath, Department of Biology and Biochemistry, Claverton Down, Bath, UK
    Microbiology 154:3503-17. 2008
    ..Here we present work to suggest that Tc proteins in Yersinia pseudotuberculosis and Yersinia pestis are not insecticidal toxins but have evolved for mammalian pathogenicity...
  65. ncbi The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation
    Christiane Gerke
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:361-71. 2005
    ..phosphorylation levels of LAT and SLP-76 are the most affected in T cells exposed to low numbers of Yersinia pseudotuberculosis. This is the first example showing that a pathogen targets these adaptor proteins in the TCR signaling ..
  66. ncbi Analysis of RovA, a transcriptional regulator of Yersinia pseudotuberculosis virulence that acts through antirepression and direct transcriptional activation
    Hien J Tran
    Junior Research Group 6, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany
    J Biol Chem 280:42423-32. 2005
    The transcription factor RovA of Yersinia pseudotuberculosis and analogous proteins in other Enterobacteriaceae activate the expression of virulence genes that play a crucial role in stress adaptation and pathogenesis...
  67. ncbi Horizontal transfer of the high-pathogenicity island of Yersinia pseudotuberculosis
    Biliana Lesic
    Yersinia Research Unit, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 187:3352-8. 2005
    ..We demonstrate here that the HPI is indeed transferable from a donor to a recipient Yersinia pseudotuberculosis strain...
  68. ncbi Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli
    M Batchelor
    Department of Biochemistry and Centre for Structural Biology, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    EMBO J 19:2452-64. 2000
    ..The interpretation of NMR-titration and mutagenesis data has enabled us to identify, for the first time, the binding site for Tir, which is located at the extremity of the Int190 moiety...
  69. ncbi Yersinia YopE is targeted for type III secretion by N-terminal, not mRNA, signals
    S A Lloyd
    Department of Cell and Molecular Biology, , , Sweden
    Mol Microbiol 39:520-31. 2001
    ..This 'rapid secretion' of YopE does not require de novo protein synthesis and is dependent upon YerA. Furthermore, this burst of YopE secretion can induce a cytotoxic response in infected HeLa cells...
  70. ncbi Intermediary metabolism, Na+, the low calcium-response, and acute disease
    Robert R Brubaker
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, USA
    Adv Exp Med Biol 603:116-29. 2007
    ..Occurrence of this event in vivo would radically alter the equilibrium of host amino acid pools thereby contributing to enhanced lethality...
  71. ncbi Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence
    Jeanette E Bröms
    Department of Medical Countermeasures, Swedish Defence Research Agency, Division of NBC Defence, SE 901 82 Umea, Sweden
    J Bacteriol 189:8417-29. 2007
    ....
  72. ncbi Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence
    Maya I Ivanov
    Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Mol Microbiol 55:1346-56. 2005
    ....
  73. ncbi The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever
    Mark Eppinger
    J Craig Venter Institute The Institute for Genomic Research, Microbial Genomics, Rockville, Maryland, United States of America
    PLoS Genet 3:e142. 2007
    ..The causative agent was later identified as Yersinia pseudotuberculosis, although the range of morbidities was vastly different from classical pseudotuberculosis symptoms...
  74. ncbi The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence
    M Marceau
    E0364 Inserm Université Lille II Faculté de Médecine Henri Warembourg Institut Pasteur de Lille, Lille, France
    Microbiology 150:3947-57. 2004
    The Yersinia pseudotuberculosis chromosome contains a seven-gene polycistronic unit (the pmrF operon) whose products share extensive homologies with their pmrF counterparts in Salmonella enterica serovar Typhimurium (S...
  75. ncbi Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP
    Michael L Fisher
    Department of Microbiology, 136 Harrison Ave, Tufts University, Boston, MA 02111, USA
    Infect Immun 75:429-42. 2007
    b>Yersinia pseudotuberculosis infects many mammals and birds including humans, livestock, and wild rodents and can be recovered from the lungs of infected animals. To determine the Y...
  76. ncbi Modulation of yersinia type three secretion system by the S1 domain of polynucleotide phosphorylase
    Jason A Rosenzweig
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA
    J Biol Chem 280:156-63. 2005
    ..Here, we show that PNPase also enhances the ability of Yersinia pseudotuberculosis and Yersinia pestis to withstand the killing activities of murine macrophages...
  77. ncbi LcrV synthesis is altered by DNA adenine methylase overproduction in Yersinia pseudotuberculosis and is required to confer immunity in vaccinated hosts
    Golnaz Badie
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara 93106, USA
    Infect Immun 72:6707-10. 2004
    b>Yersinia pseudotuberculosis mutants that overproduce the DNA adenine methylase (DamOP Yersinia) are attenuated, confer robust protective immune responses, and synthesize or secrete several Yersinia outer proteins (Yops) under conditions ..
  78. ncbi A highly specific one-step PCR - assay for the rapid discrimination of enteropathogenic Yersinia enterocolitica from pathogenic Yersinia pseudotuberculosis and Yersinia pestis
    T Arnold
    Institute of Animal Hygiene and Public Veterinary Health, Leipzig, Germany
    Syst Appl Microbiol 24:285-9. 2001
    ..By this method pathogenic isolates of Y enterocolitica can be easily identified and discriminated from other members of this genus. The entire coding sequence of the yopT effector gene of Y. pseudotuberculosis Y36 was determined...
  79. ncbi The evolution of flea-borne transmission in Yersinia pestis
    B Joseph Hinnebusch
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Curr Issues Mol Biol 7:197-212. 2005
    ..is a recent evolutionary adaptation that distinguishes Yersinia pestis, the agent of plague, from Yersinia pseudotuberculosis and all other enteric bacteria. The very close genetic relationship between Y. pestis and Y...
  80. ncbi Characterization of chromosomal regions conserved in Yersinia pseudotuberculosis and lost by Yersinia pestis
    Flavie Pouillot
    Yersinia Research Unit, Institut Pasteur, Paris Cedex 15, France
    Infect Immun 76:4592-9. 2008
    The transformation of the enteropathogenic bacterium Yersinia pseudotuberculosis into the plague bacillus, Yersinia pestis, has been accompanied by extensive genetic loss. This study focused on chromosomal regions conserved in Y...
  81. ncbi [Chronic and lingering Yersinia ileitis]
    A I Parfenov
    Ter Arkh 74:77-80. 2002
    ..1% of the total number of those with ileocecal pain. The chronic nature of Yersinia ileitis is associated with late diagnosis, developed periileitis, and immunity disorders...
  82. ncbi Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence
    Igor E Brodsky
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 4:e1000067. 2008
    ..pseudotuberculosis, and that intermediate levels of YopJ-mediated cytotoxicity are necessary for maximal systemic virulence of this bacterial pathogen...
  83. ncbi Distribution of virF/lcrF-positive Yersinia pseudotuberculosis serotype O:3 at farm level
    T Niskanen
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, PO Box 66, FIN 00014 University of Helsinki, Helsinki, Finland
    Zoonoses Public Health 55:214-21. 2008
    The distribution and persistence of pathogenic, virF/lcrF-positive Yersinia pseudotuberculosis were investigated in pigs and in the pig house environment during rearing to determine possible contamination routes of early infections...
  84. ncbi Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen
    A Roggenkamp
    Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany
    Infect Immun 65:446-51. 1997
    ..enterocolitica serotype O8 to protect against Yersinia spp. carrying the other V antigen type (LcrV-Yps) could be an explanation for the presence of plague foci in American countries...
  85. ncbi The biosynthesis and biological role of 6-deoxyheptose in the lipopolysaccharide O-antigen of Yersinia pseudotuberculosis
    Nathan Ho
    Department of Microbiology and Immunology, Infectious Diseases Research Group, University of Western Ontario, London, Ontario, Canada
    Mol Microbiol 68:424-47. 2008
    b>Yersinia pseudotuberculosis O:2a harbours 6-deoxy-d-manno-heptose in its O-antigen. The biological function of 6-deoxyheptose and its role in virulence is unknown and its biosynthetic pathway has not been demonstrated experimentally...
  86. ncbi Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan
    Taketoshi Iwata
    Division of Animal Science, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Vet Microbiol 129:404-9. 2008
    Between April 2001 and 2007, 18 Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18 Y...
  87. ncbi Modulation of complement activity in vitro and in vivo by Yersinia wild and mutant strains
    M Yordanov
    Department of Immunology, Institute of Microbiology, Sofia, Bulgaria
    Folia Microbiol (Praha) 51:27-32. 2006
    ..The serum CP activity was inhibited during the infection induced with six Y. enterocolitica and three Y. pseudotuberculosis strains in rabbits. The changed complement activity might be of importance for the course of Yersinia infections...
  88. ncbi Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ
    Sarit Lilo
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, State University of New York at Stony Brook, New York 11794 5222, USA
    Infect Immun 76:3911-23. 2008
    ..Naïve murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 activation...
  89. ncbi The Ser/Thr kinase activity of the Yersinia protein kinase A (YpkA) is necessary for full virulence in the mouse, mollifying phagocytes, and disrupting the eukaryotic cytoskeleton
    David J Wiley
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Microb Pathog 40:234-43. 2006
    ..Whether this activity is required for virulence has not been addressed. Here, we report that a Yersinia pseudotuberculosis strain expressing a kinase-inactive YpkA(D270A) variant is greatly attenuated in the mouse model of ..
  90. ncbi The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches
    Lauren K Logsdon
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 74:1516-27. 2006
    ..After oral inoculation of mice, Yersinia pseudotuberculosis yopE and yopH mutants colonize the intestines and Peyer's patches in single-strain infections but fail ..
  91. ncbi [Humoral response to selected antigens of Yersinia enterocolitica and Yersinia pseudotuberculosis in the course of yersiniosis in humans. IV. Specificity of antigens]
    Waldemar Rastawicki
    Zaklad Bakteriologii NIZP PZH w Warszawie
    Med Dosw Mikrobiol 60:27-37. 2008
    ..However, the higher cross-reactivity was observed between the LPS of Yersinia and Salmonella spp. Due to the evidence of cross-reactivity the results of serological investigations should be interpreted with caution...
  92. ncbi Evaluation of O-antigen inactivation on Pla activity and virulence of Yersinia pseudotuberculosis harbouring the pPla plasmid
    Flavie Pouillot
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 151:3759-68. 2005
    Yersinia pestis is a species that emerged recently from Yersinia pseudotuberculosis and gained an exceptional pathogenicity potential...
  93. ncbi The response regulator PhoP of Yersinia pseudotuberculosis is important for replication in macrophages and for virulence
    Jens P Grabenstein
    Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA
    Infect Immun 72:4973-84. 2004
    Yersinia pestis and Yersinia pseudotuberculosis are closely related facultative intracellular pathogens. The response regulator PhoP was previously shown to be important for Y...
  94. ncbi Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages
    Luis Gustavo Silva Monnazzi
    Department of Biological Sciences, School of Pharmaceutical Sciences, UNESP, Rodovia Araraquara, , 14801-902 Araraquara, SP, Brazil
    Immunol Lett 94:91-8. 2004
    ..The aim of this study was to assess the influence of Yersinia outer proteins (Yops) released by Yersinia pseudotuberculosis on the production of the proinflammatory cytokines, interleukin-12 (IL-12), and tumor necrosis factor ..
  95. ncbi Characterization of outer membrane proteins of Yersinia pestis and Yersinia pseudotuberculosis strains isolated from India
    Rekha Khushiramani
    Division of Microbiology, Defence R and D Establishment, Jhansi Road, Gwalior 474 002, India
    Indian J Exp Biol 42:508-14. 2004
    ..It appears that under low calcium response, the Y. pestis not only activates secretion of Yops but also a large number of other proteins, which as per the present observations are cross-reactive within the family Enterobacteriaceae...
  96. ncbi Yersinia pseudotuberculosis with limited genetic diversity is a common finding in tonsils of fattening pigs
    Taina Niskanen
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    J Food Prot 65:540-5. 2002
    ..pigs and 215 from sows, from seven different abattoirs in Finland were studied for the occurrence of Yersinia pseudotuberculosis from 1999 to 2000. The mean prevalence of Y...
  97. ncbi Experimental infections with wild and mutant Yersinia pseudotuberculosis strains in rabbits
    H Najdenski
    The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    J Vet Med B Infect Dis Vet Public Health 50:280-8. 2003
    Experimental oral infections of rabbits with a wild-type Yersinia pseudotuberculosis strain (pIB102), and two null-mutants (yopK and ypkA) were carried out with the aim to explore the possibility to use mutant strains of Y...
  98. ncbi A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface
    G W P Joshua
    London School of Hygiene and Tropical Medicine, Dept Infectious and Tropical Diseases, Keppel St, London WC1E 7HT, UK
    Microbiology 149:3221-9. 2003
    ..Similarly, 15 strains of Yersinia enterocolitica caused no effect. Strains of Yersinia pseudotuberculosis showed different levels of pathogenicity...
  99. ncbi Molecular relatedness between isolates Yersinia pseudotuberculosis from a patient and an isolate from mountain spring water
    Tae Hee Han
    Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
    J Korean Med Sci 18:425-8. 2003
    ..In past medical history, he had suffered from hepatic cirrhosis. Yersinia pseudotuberculosis was isolated from his blood and ascitic fluid...
  100. ncbi Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake
    Pamela J Bruce-Staskal
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908-0734, USA
    J Cell Sci 115:2689-700. 2002
    ..pseudotuberculosis. Importantly, these findings also contribute to a better understanding of other cellular processes that involve actin remodeling, including the host response to other microbial pathogens, cell adhesion and migration...
  101. ncbi [Yersiniosis (except the plague)]
    Seiji Kaneko
    Department of Food Hygiene and Nutrition, Tokyo Metropolitan Research Laboratory of Public Health
    Nippon Rinsho 61:459-63. 2003

Research Grants65

  1. Role of the Y. pseudotuberculosis YscF protein in toxin delivery into host cells
    Alison Davis; Fiscal Year: 2007
    ..needle-translocon interaction during infection I have isolated mutations in the needle protein of Yersinia pseudotuberculosis (YscF) that are incapable of delivering toxins into the host cell, but retain the ability to secrete ..
  2. MHC AND GAMMA/DELTA T CELL RECOGNITION
    Yueh Hsiu Chien; Fiscal Year: 2002
    ..3. Evaluation of the gamma/delta T-cell contribution to the host defense against Yersinia pseudotuberculosis infection...
  3. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
    The human pathogen Yersinia pestis, as well as its close relatives Yersinia pseudotuberculosis and Yersinia enterocolitica, employ a virulence plasmid-encoded type Ill secretion pathway to escape phagocytic killing during host infection...
  4. YERSINIA PTPASE INHIBITORS AS ANTI-PLAGUE AGENTS
    Zhong Yin Zhang; Fiscal Year: 2003
    ..in endogenous levels of host tyrosine phosphorylation associated with the binding and phagocytosis of Yersinia pseudotuberculosis. The structural basis of inhibition specificity will be revealed by the determination of the three-..
  5. MECHANISMS OF BIOSYNTHETIC FORMATION OF DEOXY SUGARS
    Hung wen Liu; Fiscal Year: 2007
    ..the past few years we have focused our efforts on the formation of ascarylose, a 3,6 dideoxy sugar from Yersinia pseudotuberculosis, and recently, we have also initiated a study to explore the biosynthesis of mycarose, a 2,6- ..
  6. INVASION FACTORS OF YERSINIA ENTEROCOLITICA
    VIRGINIA MILLER; Fiscal Year: 2001
    ..The simplest system is that of Yersinia pseudotuberculosis (Yp) and Y...
  7. Cross-Protective Vaccines Against Emerging Infectious Agents
    MICHAEL MAHAN; Fiscal Year: 2007
    ..We will focus on the LcrV passenger antigen from Yersinia pseudotuberculosis since it is a known immunogen, and a virulence factor required for secretion of effector proteins into ..
  8. Novel Therapeutics for Biodefense
    S Ken Tanaka; Fiscal Year: 2005
    ..METHODS: Mar inhibitors will be identified using a combination of in vitro assays and mouse models of Yersinia pseudotuberculosis infection...
  9. Modular Subunit Vaccine for Salmonella
    MARC JENKINS; Fiscal Year: 2007
    ..which functions as an adjuvant and contains B cell epitopes, and the beta 1 integrin-binding domain of Yersinia pseudotuberculosis, which facilitates M cell translocation of particles into the Peyer's patches...
  10. Cellular analysis of the Yersinia protein kinase A
    Kurt Schesser; Fiscal Year: 2007
    ..We have observed that ypkA strains of Yersinia pseudotuberculosis are handicapped in proliferation- and antibiotic protection-based cell culture infection assays ..