yersinia pseudotuberculosis

Summary

Summary: A human and animal pathogen causing mesenteric lymphadenitis, diarrhea, and bacteremia.

Top Publications

  1. ncbi Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: new insights into two-component system regulon plasticity in bacteria
    Claire Flamez
    Inserm U801, Université Lille II Faculté de Médecine Henri Warembourg, Institut Pasteur de Lille, Lille, France
    Int J Med Microbiol 298:193-207. 2008
  2. pmc Translocation of surface-localized effectors in type III secretion
    Karen Akopyan
    Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 108:1639-44. 2011
  3. pmc Innate immune recognition of Yersinia pseudotuberculosis type III secretion
    Victoria Auerbuch
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000686. 2009
  4. pmc Global discovery of small RNAs in Yersinia pseudotuberculosis identifies Yersinia-specific small, noncoding RNAs required for virulence
    Jovanka T Koo
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:E709-17. 2011
  5. pmc Monitoring of gene expression in bacteria during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors
    Frank Uliczka
    Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Lower Saxony, Germany
    PLoS ONE 6:e20425. 2011
  6. pmc Phosphorylated CpxR restricts production of the RovA global regulator in Yersinia pseudotuberculosis
    Junfa Liu
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 6:e23314. 2011
  7. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
  8. ncbi Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Belgium
    J Mol Evol 55:37-51. 2002
  9. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
  10. pmc Requirement for RNA helicase CsdA for growth of Yersinia pseudotuberculosis IP32953 at low temperatures
    Eveliina Palonen
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    Appl Environ Microbiol 78:1298-301. 2012

Detail Information

Publications281 found, 100 shown here

  1. ncbi Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: new insights into two-component system regulon plasticity in bacteria
    Claire Flamez
    Inserm U801, Université Lille II Faculté de Médecine Henri Warembourg, Institut Pasteur de Lille, Lille, France
    Int J Med Microbiol 298:193-207. 2008
    ..On the basis of genome-wide in silico analysis, the Gram-negative enteropathogenic bacterium Yersinia pseudotuberculosis is thought to encode 24 complete 2CSs...
  2. pmc Translocation of surface-localized effectors in type III secretion
    Karen Akopyan
    Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 108:1639-44. 2011
    ..Here, we report that T3SS substrates on the surface of Yersinia pseudotuberculosis are translocated into target cells. Upon host cell contact, purified YopH coated on Y...
  3. pmc Innate immune recognition of Yersinia pseudotuberculosis type III secretion
    Victoria Auerbuch
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000686. 2009
    ..cellular response to the virulence-associated type III secretion system (T3SS) of the human pathogen Yersinia pseudotuberculosis. We found that macrophages devoid of Toll-like receptor (TLR) signaling regulate expression of 266 ..
  4. pmc Global discovery of small RNAs in Yersinia pseudotuberculosis identifies Yersinia-specific small, noncoding RNAs required for virulence
    Jovanka T Koo
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:E709-17. 2011
    ..the interaction of many sRNAs with their targets, is required for the virulence of the enteropathogen Yersinia pseudotuberculosis. This finding suggests that sRNAs play a critical role in the regulation of virulence in this pathogen, ..
  5. pmc Monitoring of gene expression in bacteria during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors
    Frank Uliczka
    Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Lower Saxony, Germany
    PLoS ONE 6:e20425. 2011
    ..To test our vector system, we analyzed and quantified expression of Yersinia pseudotuberculosis virulence genes under laboratory conditions, in association with cells and during the infection process.
  6. pmc Phosphorylated CpxR restricts production of the RovA global regulator in Yersinia pseudotuberculosis
    Junfa Liu
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 6:e23314. 2011
    ..In the enteropathogen Y. pseudotuberculosis, we have previously reported that the extracytoplasmic stress sensing CpxA-CpxR two-component regulatory system modulates rovA expression...
  7. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    ....
  8. ncbi Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Belgium
    J Mol Evol 55:37-51. 2002
    ..All the TTSSs fall into five different clusters. The phylogenetic tree of these TTSSs is completely different from the evolutionary tree based on 16S RNA, indicating that TTSSs have been distributed by horizontal transfer...
  9. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
    ..The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve...
  10. pmc Requirement for RNA helicase CsdA for growth of Yersinia pseudotuberculosis IP32953 at low temperatures
    Eveliina Palonen
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    Appl Environ Microbiol 78:1298-301. 2012
    The expression of csdA, encoding an RNA helicase, was induced at 3°C in Yersinia pseudotuberculosis. The role of CsdA in Y. pseudotuberculosis under cold conditions was confirmed by impaired growth of insertional csdA mutants at 3°C...
  11. pmc N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
    Edwin A Yates
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Infect Immun 70:5635-46. 2002
    In gram-negative bacterial pathogens, such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis, cell-to-cell communication via the N-acylhomoserine lactone (AHL) signal molecules is involved in the cell population density-dependent ..
  12. pmc CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells
    Molly A Bergman
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000573. 2009
    ....
  13. ncbi Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA
    Steve Atkinson
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Mol Microbiol 69:137-51. 2008
    Quorum sensing (QS) in Yersinia pseudotuberculosis involves two pairs of LuxRI orthologues (YpsRI and YtbRI) and multiple N-acylhomoserine lactones (AHLs)...
  14. pmc The small RNA chaperone Hfq is required for the virulence of Yersinia pseudotuberculosis
    Chelsea A Schiano
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Infect Immun 78:2034-44. 2010
    ..The enteric pathogen Yersinia pseudotuberculosis causes the disease yersiniosis. Here we show that Hfq is required by Y...
  15. pmc The response regulator PhoP negatively regulates Yersinia pseudotuberculosis and Yersinia pestis biofilms
    Yi Cheng Sun
    Department of Cell and Tissue Biology, Program in Microbial Pathogenesis, University of California, San Francisco, CA, USA
    FEMS Microbiol Lett 290:85-90. 2009
    A few Yersinia pseudotuberculosis strains form biofilms on the head of the nematode Caenorhabditis elegans, but numerous others do not. We show that a widely used Y...
  16. ncbi Positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis
    YangBo Hu
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Microbiology 155:3622-31. 2009
    ..Here we report the positive regulation of flhDC expression by OmpR in Yersinia pseudotuberculosis. A sigma(70)-dependent promoter was identified by primer extension analysis and an active region with ..
  17. pmc Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins
    Ann Catrin Björnfot
    Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umea University, Umea, Sweden
    J Bacteriol 191:4259-67. 2009
    ..The N263A mutant was cytotoxic for HeLa cells, demonstrating that the T3SS-mediated delivery of effectors was functional. We suggest that YscU blocks Yop release and that autoproteolysis is required to relieve this block...
  18. ncbi Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia
    Yue Zhang
    Department of Molecular Genetics and Microbiology, and Center for Infectious Diseases, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, NY 11794, USA
    J Immunol 174:7939-49. 2005
    ..Macrophages expressing these proteins were infected with Yersinia pseudotuberculosis strains that secrete functionally active or inactive forms of YopJ...
  19. pmc Defective innate cell response and lymph node infiltration specify Yersinia pestis infection
    Françoise Guinet
    Unité des Yersinia, Institut Pasteur, Paris, France
    PLoS ONE 3:e1688. 2008
    Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence...
  20. ncbi Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis
    R Dessein
    INSERM, U801, Universite de Lille 2, Institut Pasteur de Lille, Lille, France
    Gut 58:771-6. 2009
    b>Yersinia pseudotuberculosis causes ileitis and mesenteric lymphadenitis by mainly invading the Peyer's patches that are positioned in the terminal ileum...
  21. ncbi Targeting bacterial virulence: inhibitors of type III secretion in Yersinia
    Anna M Kauppi
    Organic Chemistry, Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Chem Biol 10:241-9. 2003
    ..Screening of a chemical library with a luciferase reporter gene assay in viable Yersinia pseudotuberculosis furnished several compounds that inhibit the reporter gene signal expressed from the yopE promoter and ..
  22. ncbi Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole-linear ion trap mass spectrometry
    Catharine A Ortori
    Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
    Anal Bioanal Chem 387:497-511. 2007
    ..This LC-MS technique was applied to determine the relative molar ratios of AHLs produced by Yersinia pseudotuberculosis and the consequences of inactivating by mutation either or both of the AHL synthase genes (ypsI and ..
  23. ncbi Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis
    Olivia L Champion
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
    Microbiology 155:1516-22. 2009
    ..larvae of the wax moth (Galleria mellonella) are susceptible to infection with the human enteropathogen Yersinia pseudotuberculosis at 37 degrees C...
  24. ncbi A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM
    Ann Kathrin Heroven
    Institut fur Mikrobiologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Mol Microbiol 68:1179-95. 2008
    The MarR-type regulator RovA controls expression of virulence genes of Yersinia pseudotuberculosis in response to environmental signals...
  25. ncbi Crystal structure of invasin: a bacterial integrin-binding protein
    Z A Hamburger
    Division of Biology 156 29, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Science 286:291-5. 1999
    The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2...
  26. ncbi Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA, a transcriptional activator of the SlyA/Hor family
    G Nagel
    Department of Microbiology, Institute of Microbiology and Plant Physiology, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 41:1249-69. 2001
    Invasin is the primary invasive factor of Yersinia pseudotuberculosis that allows efficient internalization into eukaryotic cells...
  27. pmc The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed
    Julia Eitel
    Department of Microbiology, Institute of Microbiology and Plant Physiology, Freie Universitat Berlin, 14195 Berlin, Germany
    Infect Immun 70:4880-91. 2002
    The YadA protein is a major adhesin of Yersinia pseudotuberculosis that promotes tight adhesion to mammalian cells by binding to extracellular matrix proteins...
  28. ncbi The Csr/Rsm system of Yersinia and related pathogens: a post-transcriptional strategy for managing virulence
    Ann Kathrin Heroven
    Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    RNA Biol 9:379-91. 2012
    ..review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens...
  29. ncbi Subcellular proteomic analysis of host-pathogen interactions using human monocytes exposed to Yersinia pestis and Yersinia pseudotuberculosis
    Celia G Zhang
    Biodefense Division, Lawrence National Laboratory, Livermore, CA 94550, USA
    Proteomics 5:1877-88. 2005
    ..While Y. pestis and Yersinia pseudotuberculosis share more than 90% DNA homology, they have significantly different clinical manifestations...
  30. pmc A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    Ying Zheng
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 7:e1002026. 2011
    ..This pro-inflammatory form of apoptosis may represent an early innate immune response to highly virulent pathogens such as Y. pestis KIM that have evolved an enhanced ability to inhibit host signaling pathways...
  31. ncbi Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b
    M Skurnik
    Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Mol Microbiol 37:316-30. 2000
    ..Characterization of the O-antigen gene clusters of 21 serotypes of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Y...
  32. pmc Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in mice
    A Holmstrom
    Department of Microbiology, National Defense Research Establishment, Umea, Sweden
    Infect Immun 63:2269-76. 1995
    ..Here, we identify and characterize a novel plasmid-encoded virulence determinant of Yersinia pseudotuberculosis, YopK...
  33. pmc The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever
    Mark Eppinger
    J Craig Venter Institute The Institute for Genomic Research, Microbial Genomics, Rockville, Maryland, United States of America
    PLoS Genet 3:e142. 2007
    ..The causative agent was later identified as Yersinia pseudotuberculosis, although the range of morbidities was vastly different from classical pseudotuberculosis symptoms...
  34. ncbi Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis
    Weipeng Zhang
    Wuhan Institute of Virology, Chinese Academy of Sciences, China
    Arch Microbiol 193:351-63. 2011
    ..In the present study, we identified 4 T6SS clusters in Yersinia pseudotuberculosis and demonstrated that they were differentially thermoregulated...
  35. ncbi Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments
    E Frithz-Lindsten
    Department of Microbiology, National Defence Research Establishment, Umea, Sweden
    Mol Microbiol 25:1125-39. 1997
    ..Taken together, our data suggest that P. aeruginosa, by analogy with Yersinia, targets virulence proteins into the eukaryotic cytosol via a type III secretion-dependent mechanism as part of an anti-phagocytic strategy...
  36. ncbi The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study
    L W Lamps
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Surg Pathol 25:508-15. 2001
    ..Because special stains and cultures are often not diagnostic, PCR analysis is an excellent technique for the diagnosis of Yersinia...
  37. pmc The membrane localization domain is required for intracellular localization and autoregulation of YopE in Yersinia pseudotuberculosis
    Elin L Isaksson
    Department of Molecular Biology, Laboratory of Molecular Infectious Medicine, Umea University, S 90187 Umea, Sweden
    Infect Immun 77:4740-9. 2009
    Recent work has shown that a domain of YopE of Yersinia pseudotuberculosis ranging from amino acids 54 to 75 (R. Krall, Y. Zhang, and J. T. Barbieri, J. Biol. Chem...
  38. pmc Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization
    Sina Mohammadi
    Department of Molecular Biology and Microbiology, Tufts University School ofMedicine, 150 Harrison Ave J424, Boston, MA 02111, USA
    Infect Immun 77:4771-82. 2009
    The Yersinia pseudotuberculosis surface protein invasin binds to multiple beta1 integrins with high affinity, leading to misregulation of Rac1 activity...
  39. pmc Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model
    Lynne K Garrity-Ryan
    Paratek Pharmaceuticals, Inc, Boston, MA 02111, USA
    Infect Immun 78:4683-90. 2010
    ..b>Yersinia pseudotuberculosis lcrF-null mutants showed attenuated virulence in tissue culture and animal models of infection...
  40. ncbi Genetic analysis of the O-antigen gene clusters of Yersinia pseudotuberculosis O:6 and O:7
    Monica M Cunneen
    Division of Microbiology, School of Molecular Bioscience, University of Sydney, Sydney 2006, Australia
    Glycobiology 21:1140-6. 2011
    Among the 21 O-polysaccharide (OPS) O-antigen-based serotypes described for Yersinia pseudotuberculosis, those of O:6 and O:7 are unusual in that both contain colitose (4-keto-3,6-dideoxy-d-mannose or 4-keto-3,6-dideoxy-l-xylo-hexose), ..
  41. pmc The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function
    Sara E Thorslund
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 6:e16784. 2011
    ....
  42. ncbi O antigen gene clusters of Yersinia pseudotuberculosis
    Peter R Reeves
    School of Molecular and Microbial Biosciences, University of Sydney, NSW2006, Australia
    Adv Exp Med Biol 529:199-206. 2003
  43. pmc Serotype differences and lack of biofilm formation characterize Yersinia pseudotuberculosis infection of the Xenopsylla cheopis flea vector of Yersinia pestis
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, 903 South 4th St, Hamilton, MT 59840, USA
    J Bacteriol 188:1113-9. 2006
    ..The enteropathogen Yersinia pseudotuberculosis, from which Y. pestis recently evolved, is not transmitted by fleas. However, both Y. pestis and Y...
  44. pmc Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds
    Dai Wang
    Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Biol Chem 286:29922-31. 2011
    ..We also examine the contribution of selected target proteins to the pathogenicity of Yersinia pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.
  45. pmc Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 20:1233-43. 2012
    ..We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain...
  46. pmc Loss of a biofilm-inhibiting glycosyl hydrolase during the emergence of Yersinia pestis
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 190:8163-70. 2008
    ..The closely related Yersinia pseudotuberculosis, from which Y...
  47. pmc In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence
    Fabio Pisano
    Abteilung Molekulare Infektionsbiologie, Helmholtz Zentrum für Infektionsforschung, 38124 Braunschweig, Germany
    Infect Immun 80:1050-64. 2012
    The Yersinia pseudotuberculosis Ifp and InvC molecules are putative autotransporter proteins with a high homology to the invasin (InvA) protein...
  48. ncbi Characterisation of the type III secretion protein YscU in Yersinia pseudotuberculosis. YscU cleavage--dispensable for TTSS but essential for survival
    Moa Lavander
    Department of Medical Countermeasures, Division of NBC Defence, Swedish Defence Research Agency, S 901 82 Umeå, Sweden
    Adv Exp Med Biol 529:109-12. 2003
  49. ncbi An outbreak of gastrointestinal illness and erythema nodosum from grated carrots contaminated with Yersinia pseudotuberculosis
    Katri Jalava
    Department of Infectious Diseases Epidemiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Infect Dis 194:1209-16. 2006
    Outbreaks of Yersinia pseudotuberculosis infection have been epidemiologically linked to fresh produce, but the bacterium has not been recovered from the food items implicated...
  50. ncbi Increased virulence of Yersinia pseudotuberculosis by two independent mutations
    R Rosqvist
    Department of Cell and Microbiology, Swedish Defence Research Establishment, Umea
    Nature 334:522-4. 1988
    A chromosomally encoded protein, which mediates invasion into HeLa cells was recently identified in Yersinia pseudotuberculosis. The role of this protein (invasin) in the virulence process was not, however, investigated...
  51. pmc Sensitive and specific detection of Yersinia pseudotuberculosis by loop-mediated isothermal amplification
    Tomoko Horisaka
    Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    J Clin Microbiol 42:5349-52. 2004
    We developed a loop-mediated isothermal amplification method able to detect Yersinia pseudotuberculosis strains in 30 min by using six primers designed by targeting the inv gene...
  52. pmc The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection
    Enrique A Durand
    Department of Molecular Biology and Microbiology, Tufts University, Boston MA 02111, USA
    Cell Microbiol 12:1064-82. 2010
    ..Although Yersinia pseudotuberculosis delivers its effector proteins, called Yops, into numerous cell types grown in culture, we show that ..
  53. pmc Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing
    Riikka Laukkanen-Ninios
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, P O Box 66, FI 00014, University of Helsinki, Finland
    Environ Microbiol 13:3114-27. 2011
    Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status [Y. pseudotuberculosis sensu stricto (s.s...
  54. ncbi YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane
    A Holmstrom
    Department of Microbiology, National Defence Research Establishment, Umea, Sweden
    Mol Microbiol 24:73-91. 1997
    ..1996b). We have previously shown that YopK of Yersinia pseudotuberculosis is required for the development of a systemic infection in mice...
  55. pmc Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein
    J M Leong
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111
    EMBO J 9:1979-89. 1990
    The invasin protein of the pathogenic Yersinia pseudotuberculosis mediates entry of the bacterium into cultured mammalian cells by binding several beta 1 chain integrins...
  56. ncbi A putative DNA adenine methyltransferase is involved in Yersinia pseudotuberculosis pathogenicity
    Flavie Pouillot
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 153:2426-34. 2007
    ..pestis by a horizontally acquired region which potentially encodes another methyltransferase. YamA might thus be dispensable for Y. pestis growth and virulence because this species has acquired another gene fulfilling the same functions...
  57. ncbi The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA
    Claudia Hoffmann
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert Ludwigs Universität Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 279:16026-32. 2004
    ..Recently, a novel cytotoxic necrotizing factor termed CNFY was identified in Yersinia pseudotuberculosis strains (Lockman, H. A., Gillespie, R. A., Baker, B. D., and Shakhnovich, E. (2002) Infect. Immun...
  58. pmc Delineation and mutational analysis of the Yersinia pseudotuberculosis YopE domains which mediate translocation across bacterial and eukaryotic cellular membranes
    K Schesser
    Department of Cell and Molecular Biology, University of Umea, Sweden
    J Bacteriol 178:7227-33. 1996
    ..To identify the regions of YopE from Yersinia pseudotuberculosis that are necessary for its translocation across the bacterial and eukaryotic cellular membranes, we ..
  59. pmc Influence of the Cpx extracytoplasmic-stress-responsive pathway on Yersinia sp.-eukaryotic cell contact
    Katrin E Carlsson
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Infect Immun 75:4386-99. 2007
    ..This is true of the Yersinia pseudotuberculosis Ysc-Yop type III secretion system...
  60. pmc Horizontal transfer of the high-pathogenicity island of Yersinia pseudotuberculosis
    Biliana Lesic
    Yersinia Research Unit, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 187:3352-8. 2005
    ..We demonstrate here that the HPI is indeed transferable from a donor to a recipient Yersinia pseudotuberculosis strain...
  61. pmc Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes
    A V Karlyshev
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, University of London, London WC1E 7HT, United Kingdom
    Infect Immun 69:7810-9. 2001
    Yersinia pestis, the causative agent of plague, and the enteropathogen Yersinia pseudotuberculosis have nearly identical nucleotide similarity yet cause markedly different diseases...
  62. ncbi Invasin and beyond: regulation of Yersinia virulence by RovA
    Damon W Ellison
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8230, St Louis, MO 63110, USA
    Trends Microbiol 12:296-300. 2004
    ..regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis. Disruption of rovA increases the LD(50) of the organism when inoculated using the oral route...
  63. pmc ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice
    Warangkhana Songsungthong
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Cell Microbiol 12:988-1001. 2010
    ..A screen identifying YopE mutants in Yersinia pseudotuberculosis that interact with different Rho GTPases showed that YopE residues at positions 102, 106, 109 and 156 ..
  64. ncbi Yersinia pestis pH 6 antigen forms fimbriae and is induced by intracellular association with macrophages
    L E Lindler
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D C 20307 5100
    Mol Microbiol 8:311-24. 1993
    ..Together with an earlier study showing that a Y. pestis psaA mutant was reduced in virulence, these results demonstrate that the expression of fimbriae which are induced in host macrophages is involved in plague pathogenesis...
  65. pmc Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis
    P S G Chain
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 101:13826-31. 2004
    ..causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and ..
  66. pmc The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence
    Melissa W McCoy
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    Infect Immun 78:2584-98. 2010
    ..We performed a systematic deletion analysis of YopM in Yersinia pseudotuberculosis to determine which regions are required for RSK1 interactions, nuclear localization, virulence, and ..
  67. ncbi The biosynthesis and biological role of lipopolysaccharide O-antigens of pathogenic Yersiniae
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, P O Box 63, FIN 00014 Helsinki, Finland
    Carbohydr Res 338:2521-9. 2003
    ....
  68. ncbi Pathogenic Yersinia enterocolitica 2/O:9 and Yersinia pseudotuberculosis 1/O:1 strains isolated from human and non-human sources in the Plateau State of Nigeria
    Ameh E J Okwori
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Food Microbiol 26:872-5. 2009
    ..enterocolitica and Yersinia pseudotuberculosis. Surprisingly, ail-positive Y. enterocolitica and inv-positive Y...
  69. ncbi Comparative analysis of type III effector translocation by Yersinia pseudotuberculosis expressing native LcrV or PcrV from Pseudomonas aeruginosa
    Jeanette E Bröms
    Department of Molecular Biology, Umea University, Umea, Sweden
    J Infect Dis 188:239-49. 2003
    ..Thus, a PcrV complex with native P. aeruginosa translocon components is required to form fully functional pores for complete complementation of effector translocation in Yersinia...
  70. ncbi Cell invasion and IL-8 production pathways initiated by YadA of Yersinia pseudotuberculosis require common signalling molecules (FAK, c-Src, Ras) and distinct cell factors
    Julia Eitel
    Junior Research Group 6, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Cell Microbiol 7:63-77. 2005
    The YadA protein of Yersinia pseudotuberculosis promotes tight adhesion and invasion into mammalian cells through beta(1)-integrins...
  71. ncbi Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia
    Markus K Dahlgren
    Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    J Med Chem 50:6177-88. 2007
    ..A PLS discriminant analysis (PLS-DA) model was derived using the same descriptor set as that for the Hi-PLS model. Both models were validated with an external test set...
  72. ncbi OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis
    YangBo Hu
    Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, PR China
    Microbiology 155:2522-31. 2009
    b>Yersinia pseudotuberculosis is an enteric bacterium which must overcome the acidic stress in host organs for successful colonization, but how this bacterium survives in acidic conditions remains largely unknown...
  73. ncbi Molecular epidemiology of Yersinia pseudotuberculosis
    Hiroshi Fukushima
    Shimane Prefectural Institute of Public Health and Environmental Science, 582 1 Nishihamasada, Matsue, Shimane 690 0122, Japan
    Adv Exp Med Biol 529:357-8. 2003
  74. ncbi Yersinia pseudotuberculosis is resistant to killing by human neutrophils
    Thomas R Laws
    Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, UK
    Microbes Infect 13:607-11. 2011
    The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro...
  75. pmc Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain
    Thierry Blisnick
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, Paris 75724, France
    Infect Immun 76:3808-16. 2008
    We evaluated the possibility of using Yersinia pseudotuberculosis as a live vaccine against plague because it shares high genetic identity with Y...
  76. ncbi The O-specific polysaccharide structure and gene cluster of serotype O:12 of the Yersinia pseudotuberculosis complex, and the identification of a novel L-quinovose biosynthesis gene
    Cristina De Castro
    Department of Chemical Sciences, University Federico II of Naples, Naples, Italy
    Glycobiology 23:346-53. 2013
    A major virulence factor for Yersinia pseudotuberculosis is lipopolysaccharide, including O-polysaccharide (OPS). Currently, the OPS based serotyping scheme for Y...
  77. pmc Population structure and evolution of pathogenicity of Yersinia pseudotuberculosis
    Shear Lane Ch'ng
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Appl Environ Microbiol 77:768-75. 2011
    b>Yersinia pseudotuberculosis is an enteric human pathogen but is widespread in the environment...
  78. ncbi Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold
    Roberta Donadini
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Structure 12:145-56. 2004
    ..b>Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other ..
  79. ncbi The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis
    M S Francis
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    Mol Microbiol 42:1075-93. 2001
    The enteropathogen Yersinia pseudotuberculosis is a model system used to study the molecular mechanisms by which Gram-negative pathogens secrete and subsequently translocate antihost effector proteins into target eukaryotic cells by a ..
  80. ncbi Comparison of the structure and regulation of the udp gene of Vibrio cholerae, Yersinia pseudotuberculosis, Salmonella typhimurium, and Escherichia coli
    Maria Zolotukhina
    State Research Institute of Genetics and Selection of Industrial Microorganisms, 113545 Moscow, Russia
    Res Microbiol 154:510-20. 2003
    The nucleotide sequences of the udp gene encoding uridine phosphorylase of Yersinia pseudotuberculosis and Vibrio cholerae are presented and compared with the udp sequences of Salmonella typhimurium and Escherichia coli...
  81. pmc Expression of signal transduction system encoding genes of Yersinia pseudotuberculosis IP32953 at 28°C and 3°C
    Eveliina Palonen
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e25063. 2011
    b>Yersinia pseudotuberculosis is a significant psychrotrophic food pathogen whose cold tolerance mechanisms are poorly understood...
  82. ncbi Analysis of RovA, a transcriptional regulator of Yersinia pseudotuberculosis virulence that acts through antirepression and direct transcriptional activation
    Hien J Tran
    Junior Research Group 6, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Biol Chem 280:42423-32. 2005
    The transcription factor RovA of Yersinia pseudotuberculosis and analogous proteins in other Enterobacteriaceae activate the expression of virulence genes that play a crucial role in stress adaptation and pathogenesis...
  83. ncbi Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation
    A Tansini
    Department of Biological Sciences, School of Pharmaceutical Sciences, UNESP Sao Paulo State University, Araraquara, SP, Brazil
    Scand J Immunol 69:310-8. 2009
    T helper 1 cells play a crucial role in the clearance of Yersinia pseudotuberculosis infection. By producing cytokines and presenting antigens to T cells, activated macrophages can orientate the adaptive immune response...
  84. ncbi Small non-coding RNA SraG regulates the operon YPK_1206-1205 in Yersinia pseudotuberculosis
    Pei Lu
    Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan, China
    FEMS Microbiol Lett 331:37-43. 2012
    ..Here, we compared the protein expression patterns between the wild-type and an sraG-depleted mutant of Yersinia pseudotuberculosis by proteomic analysis...
  85. pmc Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion
    Ayad A A Amer
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    J Bacteriol 193:6683-700. 2011
    ..molecular constraints influence translocator secretion, we scrutinized this region within YopD from Yersinia pseudotuberculosis. Mutations in the 5' end of yopD that resulted in specific disruption of the mRNA sequence did not ..
  86. pmc Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
    Camille Jung
    Universite Paris Diderot, UMR843, Paris, France
    J Clin Invest 122:2239-51. 2012
    ..In mice infected with Yersinia pseudotuberculosis, we found that PP barrier dysfunction is dependent on the Yersinia virulence plasmid and the expression ..
  87. pmc Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae
    Yvonne Göpel
    Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, 37077 Gottingen, Germany
    Nucleic Acids Res 39:1294-309. 2011
    ..Here, we analyzed the transcriptional regulation of glmY/glmZ from Yersinia pseudotuberculosis, Salmonella typhimurium and Escherichia coli, as representatives for other enterobacterial species, ..
  88. ncbi The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae
    Stewart J Hinchliffe
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Microbiology 154:1117-31. 2008
    ..Phenotypic assays on defined mutants confirmed a role for the phosphorelay in these processes in both Y. pseudotuberculosis and Y. enterocolitica...
  89. ncbi Adaptation of enteropathogenic Yersinia to low growth temperature
    Eveliina Palonen
    Department of Food and Environmental Hygiene, University of Helsinki, Finland
    Crit Rev Microbiol 36:54-67. 2010
    Yersinia enterocolitica and Yersinia pseudotuberculosis are important foodborne pathogens that cause infections through contaminated refrigerated food. Their cold tolerance mechanisms are therefore of special interest...
  90. ncbi Exoenzyme T of Pseudomonas aeruginosa elicits cytotoxicity without interfering with Ras signal transduction
    C Sundin
    Department of Microbiology, FOI NBC-Defence, , Sweden
    Cell Microbiol 3:237-46. 2001
    ..a strategy by which ExoT was delivered into host cells by the heterologous type III secretion system of Yersinia pseudotuberculosis. ExoT was found to induce a rounded cell morphology and to mediate disruption of actin microfilaments, ..
  91. pmc Yersinia pseudotuberculosis-induced calcium signaling in neutrophils is blocked by the virulence effector YopH
    K Andersson
    Division of Medical Microbiology, Department of Health and Environment, Linkoping University, SE 581 85 Linkoping, Sweden
    Infect Immun 67:2567-74. 1999
    ..In this study we investigated the effect of Yersinia pseudotuberculosis on Ca2+ signaling in polymorphonuclear neutrophils...
  92. ncbi Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia
    Markus K Dahlgren
    Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    Bioorg Med Chem 18:2686-703. 2010
    ..salicylidene acylhydrazides as inhibitors of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. SMD and subsequent synthesis furnished 50 salicylidene acylhydrazides in high purity...
  93. pmc Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB protein
    Michelle B Ryndak
    Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, 130 Life Sciences, SUNY at Stony Brook, Stony Brook, NY 11794 5222, USA
    Infect Immun 73:2433-43. 2005
    ..b>Yersinia pseudotuberculosis strains expressing the mutant YopB proteins were used to infect macrophages or epithelial cells...
  94. pmc Urease is not involved in the virulence of Yersinia pseudotuberculosis in mice
    B Riot
    INSERM U411, Faculte de Medecine Necker, Paris, France
    Infect Immun 65:1985-90. 1997
    A chromosomal locus (ure) involved in the production of urease activity in the bacterial pathogen Yersinia pseudotuberculosis was characterized. The genetic organization of the Y...
  95. pmc A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH
    M Rimpiläinen
    Department of Cell and Molecular Biology, University of Umea, Sweden
    J Bacteriol 174:3355-63. 1992
    ..51. Overexpression of LcrQ in trans in wild-type Yersinia pseudotuberculosis YPIII(pIB102) changed the phenotype from calcium dependence to calcium independence and inhibited Yop ..
  96. pmc Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages
    Yue Zhang
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, SUNY Stony Brook, Stony Brook, New York 11794 5222, USA
    Infect Immun 76:4299-310. 2008
    b>Yersinia pseudotuberculosis uses a plasmid (pYV)-encoded type III secretion system (T3SS) to translocate a set of effectors called Yops into infected host cells...
  97. ncbi The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
    I Bolin
    Department of Cell Biology and Microbiology, National Defence Research Institute, Umea, Sweden
    Mol Microbiol 2:237-45. 1988
    The basic Yop2b protein, encoded by the virulence plasmid pIBI of Yersinia pseudotuberculosis, is produced under Ca2+-deficient conditions...
  98. pmc The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium
    T Bergman
    Department of Cell and Molecular Biology, University of Umea, Sweden
    J Bacteriol 176:2619-26. 1994
    ..These findings indicate that the genes originated from a common ancestor...
  99. ncbi Th1-type immune response to infection by pYV-cured phoP-phoQ null mutant of Yersinia pseudotuberculosis is defective in mouse model
    Subodh Kumar
    Division of Microbiology, Defence R and D Establishment, Jhansi Road, Gwalior, 474 002, India
    Antonie Van Leeuwenhoek 95:91-100. 2009
    The PhoP-PhoQ two-component system of Yersinia pseudotuberculosis, a Gram-negative enteric pathogen which causes a variety of gastrointestinal and extraintestinal infections in humans, has been shown to be necessary for virulence...
  100. ncbi Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1
    Olivia L Champion
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter EX4 4QD, UK
    Microbiology 157:1115-22. 2011
    ..In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation...
  101. ncbi Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides
    Anna M Kauppi
    Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Bioorg Med Chem 15:6994-7011. 2007
    ..Based on the data multivariate QSAR models were established and the final Hi-PLS model showed good correlation between experimentally determined % inhibition and the calculated % inhibition of the reporter-gene signal...

Research Grants32

  1. Host iron availability in the pathogenesis of enteropathogenic Yersinia
    VICTORIA AUERBUCH STONE; Fiscal Year: 2013
    ..We have identified a gene in the foodborne pathogen Yersinia pseudotuberculosis that controls expression of the type III secretion system (T3SS), a specialized apparatus required by ..
  2. Modulation of Inflammasome Activation by Yersinia
    Igor E Brodsky; Fiscal Year: 2013
    ..In particular we use Yersinia pseudotuberculosis, which expresses many of the same virulence factors as its close relative and plague pathogen Yersinia ..
  3. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2010
    ..which functions as an adjuvant and contains B cell epitopes, and the beta 1 integrin-binding domain of Yersinia pseudotuberculosis, which facilitates M cell translocation of particles into the Peyer's patches...
  4. Small, noncoding RNAs and the evolution of Yersinia pestis virulence
    Wyndham W Lathem; Fiscal Year: 2013
    ..Yersinia pestis, responsible for the devastating disease plague, and Yersinia pseudotuberculosis, the causative agent of the mild, self-limiting disease Yersiniosis, are excellent examples of this ..
  5. Analysis of the interplay between cell adhesion and bacterial protein translocati
    Ralph R Isberg; Fiscal Year: 2013
    ..This proposal will focus on the TTSS of Yersinia pseudotuberculosis and its relationship to the outer membrane protein invasin, which promotes bacterial uptake into host ..
  6. Spatial Control of Host Cell Signaling by a Bacterial Pathogen
    GREGORY THOMAS CRIMMINS; Fiscal Year: 2012
    ..the lL-10 and lL-6 receptors and the induction of inflammatory immune responses upon infection with Yersinia pseudotuberculosis. Finally, I will examine the role this manipulation of host protein localization plays in Yersinia ..
  7. Host Responses to Yersinia Pseudotuberculosis: Cytolytic T cells &Apoptosis
    Molly A Bergman; Fiscal Year: 2012
    ....
  8. MOLECULAR BASIS OF YERSINIA/HOST CELL INTERACTION
    Ralph R Isberg; Fiscal Year: 2011
    ..factors collaborate, focusing on proteins translocated via the Type III Secretion System (TTSS) of Yersinia pseudotuberculosis. In particular, interactions between three bacterial components will be dissected: invasin, the TTSS ..
  9. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
    The human pathogen Yersinia pestis, as well as its close relatives Yersinia pseudotuberculosis and Yersinia enterocolitica, employ a virulence plasmid-encoded type Ill secretion pathway to escape phagocytic killing during host infection...
  10. YERSINIA PTPASE INHIBITORS AS ANTI-PLAGUE AGENTS
    Zhong Yin Zhang; Fiscal Year: 2003
    ..in endogenous levels of host tyrosine phosphorylation associated with the binding and phagocytosis of Yersinia pseudotuberculosis. The structural basis of inhibition specificity will be revealed by the determination of the three-..
  11. MOLECULAR BASIS OF YERSINIA/HOST CELL INTERACTION
    RALPH ISBERG; Fiscal Year: 2009
    ..As a model system, Yersinia pseudotuberculosis is being studied in order to gain detailed information on the function of bacterial- and host-encoded ..
  12. Host Cell Contribution to Type III Secretion in Yersinia pseudotuberculosis
    Kerri Lynn Sheahan; Fiscal Year: 2009
    ..RNAi knockdown of host cell factors inhibits a specific activity of a type 3 delivered effector from Yersinia pseudotuberculosis. The Yersinia effector YopE is a Rho GTPase activating protein, which stimulates the hydrolysis of GTP ..
  13. INVASION FACTORS OF YERSINIA ENTEROCOLITICA
    VIRGINIA MILLER; Fiscal Year: 2001
    ..The simplest system is that of Yersinia pseudotuberculosis (Yp) and Y...
  14. Cross-Protective Vaccines Against Emerging Infectious Agents
    MICHAEL MAHAN; Fiscal Year: 2007
    ..We will focus on the LcrV passenger antigen from Yersinia pseudotuberculosis since it is a known immunogen, and a virulence factor required for secretion of effector proteins into ..
  15. Novel Therapeutics for Biodefense
    S Ken Tanaka; Fiscal Year: 2005
    ..METHODS: Mar inhibitors will be identified using a combination of in vitro assays and mouse models of Yersinia pseudotuberculosis infection...
  16. DNA METHYLATION AND PILI GENE REGULATION
    David Low; Fiscal Year: 2002
    ..Salmonella typhimurium, and Yersinia pseudotuberculosis Finally, the pap system is a paradigm for the study of epigenetic regulation in eukaryotes, in which ..
  17. MOLECULAR BASIS OF YERSINIA-HOST CELL INTERACTION
    RALPH ISBERG; Fiscal Year: 1999
    ..As a model system, Yersinia pseudotuberculosis is being studied in order to gain detailed information on the function of bacterial- and host-encoded ..
  18. Bioemulsifying Vaccine Delivery System for Immunomodulation
    David Kaplan; Fiscal Year: 2009
    ..the variants in an in vivo vaccine disease model based on the utilization of emulsan with a recombinant Yersinia pseudotuberculosis vaccine to induce protective immunity in a murine disease model (Aim #3), and the efficacy of emulsans ..
  19. SHORT-TERM TRAINING FOR MINORITY STUDENTS PROGRAM
    Joan Mecsas; Fiscal Year: 2007
    ..Our long-range goal is for these students to become independent scientists in academia or industry, and in this capacity, serve as mentors for other minority students. ..
  20. Genetics of Survival of Yersinia pseudotuberculosis
    Joan Mecsas; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Yersinia pseudotuberculosis is a gram-negative, enteric bacterial pathogen that causes gastroenteritis, mesenteric lymphadenitis, which can be misdiagnosed as appendicitis leading to unnecessary ..
  21. HOST CELL SIGNALING PATHWAYS INDUCED BY SALMONELLA
    JORGE GALAN; Fiscal Year: 2002
    ..typhi. ..
  22. Role of IL-1 in Yersinia Induced Intestinal Inflammation
    Peter Dube; Fiscal Year: 2002
    ..These genes will be screened for their ability to induce IL-1 in vivo. Inflammation will be assessed histologically. The host factors will be identify by producing blocking antibodies ..
  23. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  24. SALMONELLA TYPE 3 SECRETION SYSTEM FOR ANTIGEN DELIVERY
    JORGE GALAN; Fiscal Year: 2004
    ..This will significantly broaden the utility of avirulent strains of Salmonella as platforms for the development of polyvalent vaccines. ..
  25. Differential Gene Expresion in Yersinia pestis
    Kathleen McDonough; Fiscal Year: 2005
    ..Characterization of Y. pestis-specific genes and their proteins in future studies will also identify potential mechanisms by which Y. pestis emerged as a new pathogen distinct from Yptb. ..
  26. Molecular Mechanisms of Salmonella typhi Pathogenicity
    Jorge E Galan; Fiscal Year: 2010
    ..abstract_text> ..
  27. Identifying targets for diagnosing oral candidiasis
    David Schofield; Fiscal Year: 2005
    ..Since Candida species are the most important fungal pathogen of the oral cavity, the rapid and accurate diagnosis of oral candidiasis using novel disease biomarkers will significantly improve oral health. ..
  28. Inhibitors of Yersinia Yop Type III Secretion(RMI)
    Joan Mecsas; Fiscal Year: 2005
    ..In addition, these inhibitors will be valuable tools to probe the structure and function of type III secretion systems encoded by Yersinia species and other Gram-negative bacterial pathogens. ..
  29. Role of Yersinia Yops in an Animal Infection Model
    Joan Mecsas; Fiscal Year: 2007
    ..to colonize and cause disease in animal tissues and to understand the host defenses that prevent, combat and/or contain Yersinia infection in tissues. ..
  30. The type III secretion effector protein interactome
    JORGE GALAN; Fiscal Year: 2008
    ..It is expected that these studies will provide an extremely useful resource for the understanding of the pathogenesis of many important bacterial diseases. [unreadable] [unreadable] [unreadable]..
  31. Host response to Yersinia pestis infection
    Peter Dube; Fiscal Year: 2008
    ..These studies will improve our understanding of the host immune response to Y. pestis infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Interaction of Yersinia with dendritic cells
    Igor Brodsky; Fiscal Year: 2007
    b>Yersinia pseudotuberculosis is a close relative of Yersinia pestis, the etiologic agent of plague, and has been studied as a model for understanding mechanisms of Yersinia pathogenesis...