shigella dysenteriae

Summary

Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is extremely pathogenic and causes severe dysentery. Infection with this organism often leads to ulceration of the intestinal epithelium.

Top Publications

  1. ncbi Protective role of lactobacilli in Shigella dysenteriae 1-induced diarrhea in rats
    Guhapriya Moorthy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India
    Nutrition 23:424-33. 2007
  2. ncbi Antimicrobial resistance in Shigella species isolated in Dakar, Senegal (2004-2006)
    Jean Marie Sire
    Laboratoire de Biologie Medicale, Institut Pasteur, Dakar, Senegal
    Jpn J Infect Dis 61:307-9. 2008
  3. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
  4. ncbi Release of Shiga toxin by membrane vesicles in Shigella dysenteriae serotype 1 strains and in vitro effects of antimicrobials on toxin production and release
    Shanta Dutta
    Microbiology Division, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Microbiol Immunol 48:965-9. 2004
  5. pmc Genetics and regulation of heme iron transport in Shigella dysenteriae and detection of an analogous system in Escherichia coli O157:H7
    M Mills
    Department of Microbiology, University of Texas at Austin 78712, USA
    J Bacteriol 177:3004-9. 1995
  6. ncbi The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island
    S A Vokes
    Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712 1095, USA
    Mol Microbiol 33:63-73. 1999
  7. ncbi Porin of Shigella dysenteriae directly promotes toll-like receptor 2-mediated CD4+ T cell survival and effector function
    Amlan Biswas
    Division of Immunology, National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700 010, West Bengal, India
    Mol Immunol 46:3076-85. 2009
  8. pmc Temporal shifts in the dominance of serotypes of Shigella dysenteriae from 1999 to 2002 in Dhaka, Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, Dhaka 1000, Bangladesh
    J Clin Microbiol 41:5053-8. 2003
  9. ncbi Shigellosis in children: a clinico-epidemiological comparison between Shigella dysenteriae type I and Shigella flexneri
    A S Faruque
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Ann Trop Paediatr 18:197-201. 1998
  10. ncbi Acanthamoeba castellanii an environmental host for Shigella dysenteriae and Shigella sonnei
    Amir Saeed
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, 141 86, Stockholm, Sweden
    Arch Microbiol 191:83-8. 2009

Detail Information

Publications194 found, 100 shown here

  1. ncbi Protective role of lactobacilli in Shigella dysenteriae 1-induced diarrhea in rats
    Guhapriya Moorthy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India
    Nutrition 23:424-33. 2007
    ..The present study evaluated the effect of Lactobacillus rhamnosus and Lactobacillus acidophilus on neutrophil infiltration and lipid peroxidation during Shigella dysenteriae 1-induced diarrhea in rats.
  2. ncbi Antimicrobial resistance in Shigella species isolated in Dakar, Senegal (2004-2006)
    Jean Marie Sire
    Laboratoire de Biologie Medicale, Institut Pasteur, Dakar, Senegal
    Jpn J Infect Dis 61:307-9. 2008
    ..were identified as Shigella flexneri, 75 (45%) as Shigella sonnei, 5 (3%) as Shigella boydii, and 4 (2%) as Shigella dysenteriae. Disk diffusion testing revealed that the majority of isolates were resistant to sulphonamides, ..
  3. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
    ..Innovative strategies, including development of vaccines against the most common serotypes, could provide substantial benefits...
  4. ncbi Release of Shiga toxin by membrane vesicles in Shigella dysenteriae serotype 1 strains and in vitro effects of antimicrobials on toxin production and release
    Shanta Dutta
    Microbiology Division, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Microbiol Immunol 48:965-9. 2004
    Effects of various antimicrobials on in vitro Shiga toxin production and release by Shigella dysenteriae serotype 1 was investigated in this study with particular reference to the role of outer membrane vesicles in toxin release by the ..
  5. pmc Genetics and regulation of heme iron transport in Shigella dysenteriae and detection of an analogous system in Escherichia coli O157:H7
    M Mills
    Department of Microbiology, University of Texas at Austin 78712, USA
    J Bacteriol 177:3004-9. 1995
    Shigella species can use heme as the sole source of iron. In this work, the heme utilization locus of Shigella dysenteriae was cloned and characterized. A cosmid bank of S...
  6. ncbi The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island
    S A Vokes
    Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712 1095, USA
    Mol Microbiol 33:63-73. 1999
    ..coli. Shigella dysenteriae type 1 strains do not produce aerobactin but do contain sequences downstream of selC that are homologous to ..
  7. ncbi Porin of Shigella dysenteriae directly promotes toll-like receptor 2-mediated CD4+ T cell survival and effector function
    Amlan Biswas
    Division of Immunology, National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700 010, West Bengal, India
    Mol Immunol 46:3076-85. 2009
    Porin of Shigella dysenteriae type 1 up-regulated Toll-like receptor (TLR)2 on CD3-stimulated CD4(+) T cells but could not induce the expression of other TLRs...
  8. pmc Temporal shifts in the dominance of serotypes of Shigella dysenteriae from 1999 to 2002 in Dhaka, Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, Dhaka 1000, Bangladesh
    J Clin Microbiol 41:5053-8. 2003
    A total of 358 Shigella dysenteriae strains isolated from patients attending the Dhaka treatment center of the International Centre for Diarrheal Disease Research, Bangladesh, between the years 1999 and 2002 were included in this study. S...
  9. ncbi Shigellosis in children: a clinico-epidemiological comparison between Shigella dysenteriae type I and Shigella flexneri
    A S Faruque
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Ann Trop Paediatr 18:197-201. 1998
    ..the clinical and epidemiological features of 390 children under 5 years of age infected with either Shigella dysenteriae type I or Shigella flexneri attending a diarrhoea treatment centre from 1993 to 1995 in Dhaka, Bangladesh...
  10. ncbi Acanthamoeba castellanii an environmental host for Shigella dysenteriae and Shigella sonnei
    Amir Saeed
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, 141 86, Stockholm, Sweden
    Arch Microbiol 191:83-8. 2009
    The interaction between Shigella dysenteriae or Shigella sonnei and Acanthamoeba castellanii was studied by viable counts, gentamicin assay and electron microscopy...
  11. pmc Enterohaemorrhagic Escherichia coli and Shigella dysenteriae type 1-induced haemolytic uraemic syndrome
    C Mark Taylor
    Department of Nephrology, Birmingham Children s Hospital, Birmingham, B4 6NH, UK
    Pediatr Nephrol 23:1425-31. 2008
    ..form is that induced by shigatoxin producing Escherichia coli (STEC) and, in some tropical regions, by Shigella dysenteriae type 1...
  12. pmc Shigella dysenteriae ShuS promotes utilization of heme as an iron source and protects against heme toxicity
    Elizabeth E Wyckoff
    The University of Texas, Section of Molecular Genetics and Microbiology, 1 University Station A5000, Austin, TX 78712 0162, USA
    J Bacteriol 187:5658-64. 2005
    b>Shigella dysenteriae serotype 1, a major cause of bacillary dysentery in humans, can use heme as a source of iron...
  13. ncbi Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells
    E V O'Loughlin
    Department of Gastroenterology, The Royal Alexandra Hospital for Children, PO Box 3515, Parramatta 2124, Westmead NSW, Australia
    Microbes Infect 3:493-507. 2001
    b>Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome...
  14. ncbi Shigellosis: the current status of vaccine development
    Mi Na Kweon
    Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Kwanak gu, Seoul, Korea
    Curr Opin Infect Dis 21:313-8. 2008
    ..Owing to the wide range of Shigella serotypes and subtypes, there is a need for a multivalent vaccine representing prevalent species and serotypes...
  15. pmc Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1
    N A Strockbine
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    J Bacteriol 170:1116-22. 1988
    The structural genes for Shiga toxin, designated stx A and stx B, were cloned from Shigella dysenteriae type 1 3818T, and a nucleotide sequence analysis was performed...
  16. pmc A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology
    Lorenz von Seidlein
    International Vaccine Institute, Seoul, Korea
    PLoS Med 3:e353. 2006
    ..We conducted a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia...
  17. pmc Isolation of Shigella dysenteriae type 1 and S. flexneri strains from surface waters in Bangladesh: comparative molecular analysis of environmental Shigella isolates versus clinical strains
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Appl Environ Microbiol 68:3908-13. 2002
    ..Shigella isolates were positive for the chromosomal multicopy invasion-associated gene ipaH and all Shigella dysenteriae type 1 isolates were positive for the stx1 gene in addition to ipaH...
  18. pmc Clonal multidrug-resistant Shigella dysenteriae type 1 strains associated with epidemic and sporadic dysenteries in eastern India
    Gururaja Perumal Pazhani
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata 700 010, India
    Antimicrob Agents Chemother 48:681-4. 2004
    Multidrug-resistant strains of Shigella dysenteriae type 1 were implicated in three outbreaks and sporadic cases of dysentery in eastern India in 2002 and 2003...
  19. ncbi Development of a new guinea-pig model of shigellosis
    Soumik Barman
    Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India
    FEMS Immunol Med Microbiol 62:304-14. 2011
    ..In this study, guinea-pigs were discretely infected with virulent Shigella dysenteriae type 1 and Shigella flexneri type 2a into the cecocolic junction after ligation of the distal cecum...
  20. pmc RNA-mediated thermoregulation of iron-acquisition genes in Shigella dysenteriae and pathogenic Escherichia coli
    Andrew B Kouse
    Ohio University, Department of Biology, Molecular Cell Biology Program Athens, Ohio, United States of America
    PLoS ONE 8:e63781. 2013
    ..of ShuA, an outer-membrane receptor required for the utilization of heme as a source of nutrient iron by Shigella dysenteriae, a pathogenic bacterium that causes severe diarrheal diseases in humans...
  21. ncbi Structure of the Shigella dysenteriae haem transport locus and its phylogenetic distribution in enteric bacteria
    E E Wyckoff
    Department of Microbiology and the Institute for Cellular and Molecular Biology, University of Texas, Austin 78712, USA
    Mol Microbiol 28:1139-52. 1998
    ..dysenteriae, indicating that, in these strains, the haem transport locus has an organization similar to that in S. dysenteriae, and it is located in the same relative position on the chromosome...
  22. pmc Shigella dysenteriae serotype 1, Kolkata, India
    Shanta Dutta
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Emerg Infect Dis 9:1471-4. 2003
    Since July 2002, bacteriologically confirmed shigellosis cases have increased, and multidrug-resistant Shigella dysenteriae serotype 1 strains have reemerged in patients hospitalized with diarrhea in Kolkata, India...
  23. pmc A novel Shigella dysenteriae serovar isolated in Canada
    P L Melito
    Bacteriology and Enteric Disease Program, National Microbiology Laboratory, 1015 Arlington St, Winnipeg, Manitoba R3E 3R2, Canada
    J Clin Microbiol 43:740-4. 2005
    ..Serologically, these strains produced weak reactions in Shigella dysenteriae serovars 4 and 16 and Escherichia coli O159 and O173 antisera...
  24. pmc Newly emerged multiple-antibiotic-resistant Shigella dysenteriae type 1 strains in and around Kolkata, India, are clonal
    Shanta Dutta
    J Clin Microbiol 41:5833-4. 2003
  25. ncbi Reactive arthritis associated with Shigella dysenteriae type 1 infection
    R N Mazumder
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B
    J Diarrhoeal Dis Res 15:21-4. 1997
    b>Shigella dysenteriae type 1 causes the most severe form of bacillary dysentery. The spectrum of illness ranges from mild watery diarrhoea to severe bloody diarrhoea...
  26. pmc Functional characterization of the Shigella dysenteriae heme ABC transporter
    Kimberly A Burkhard
    Department of Pharmaceutical Sciences, School of Pharmacy, 20 Penn Street, University of Maryland, Baltimore, Maryland 21201 1140, USA
    Biochemistry 47:7977-9. 2008
    The heme ATP binding cassette (ABC) transporter, ShuUV, of Shigella dysenteriae has been incorporated into proteoliposomes...
  27. ncbi The ShuS protein of Shigella dysenteriae is a heme-sequestering protein that also binds DNA
    A Wilks
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore 21201 1180, USA
    Arch Biochem Biophys 387:137-42. 2001
    The ability of Shigella dysenteriae to utilize heme as an iron source is dependent on the iron-regulated expression of a number of genes including the outermembrane receptor ShuA and the cytoplasmic protein ShuS...
  28. ncbi Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response
    Amlan Biswas
    Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P 33 C I T Road, Scheme XM, Kolkata 700 010, West Bengal, India
    Mol Immunol 44:812-20. 2007
    Porin of Shigella dysenteriae type 1 coexpressed Toll-like receptor (TLR) 2 and TLR6 on peritoneal cavity (PerC) macrophages (MPhi) of C57BL/6 mice implicating that both the TLRs are essential as a combinatorial repertoire to recognize ..
  29. ncbi Characterization of the outer membrane receptor ShuA from the heme uptake system of Shigella dysenteriae. Substrate specificity and identification of the heme protein ligands
    Kimberly A Burkhard
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 282:15126-36. 2007
    b>Shigella dysenteriae, like many bacterial pathogens, has evolved outer membrane receptor-mediated pathways for the uptake and utilization of heme as an iron source...
  30. ncbi Structure of the heme/hemoglobin outer membrane receptor ShuA from Shigella dysenteriae: heme binding by an induced fit mechanism
    David Cobessi
    Institut de Biologie Structurale Jean Pierre Ebel, CEA CNRS Université Joseph Fourier, Grenoble 38027, France
    Proteins 78:286-94. 2010
    ..The structural comparisons with HasR suggest its conformational change upon the heme binding for interacting with TonB. The signaling of the heme binding could involve a hydrogen bond network going from His86 to the TonB-box...
  31. pmc Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit
    Tao Wu
    University of Maryland School of Medicine, Baltimore, MD, USA
    Infect Immun 79:4912-22. 2011
    b>Shigella dysenteriae serotype 1 (S...
  32. pmc A challenge model for Shigella dysenteriae 1 in cynomolgus monkeys (Macaca fascicularis)
    Steven T Shipley
    Department of Pathology, University of Maryland School of Medicine, Baltimore, USA
    Comp Med 60:54-61. 2010
    b>Shigella dysenteriae type 1 can cause devastating pandemics with high case fatality rates; a vaccine for Shigella is unavailable currently. Because of the risks associated with performing challenge studies with wild-type S...
  33. ncbi Genetic diversity and antibiotic resistance in Shigella dysenteriae and Shigella boydii strains isolated from children aged <5 years in Egypt
    A M el-Gendy
    Clinical Trials and Military Studies Program, U S Naval Medical Research Unit No 3, Cairo, Egypt
    Epidemiol Infect 140:299-310. 2012
    Diversity within Shigella dysenteriae (n=40) and Shigella boydii (n=30) isolates from children living in Egypt aged <5 years was investigated...
  34. pmc Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7
    Ying Wang
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa Street, TEDA, Tianjin 300457, People s Republic of China
    J Bacteriol 189:8626-35. 2007
    ..The O antigens of Shigella dysenteriae type 7 and Escherichia coli O7 contain 4-(N-acetylglycyl)amino-4,6-dideoxy-d-glucose (d-Qui4NGlyAc) and 4-..
  35. ncbi Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88, up-regulates CD80 of murine macrophage, and induces the release of interleukin-12
    Avijit Ray
    National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700 010, West Bengal, India
    FEMS Immunol Med Microbiol 39:213-9. 2003
    ..convalescing from shigellosis reacted strongly and specifically with the 38,000 Da monomer of porin of Shigella dysenteriae type 1. Since human, the only natural host of S...
  36. pmc In vitro adhesion and invasion inhibition of Shigella dysenteriae, Shigella flexneri and Shigella sonnei clinical strains by human milk proteins
    Emerson da Motta Willer
    Laboratorio de Microbiologia, Departamento de Biologia Celular, Instituto de Biologia, Universidade de Brasilia, 71910 900, Brasilia DF, Brazil
    BMC Microbiol 4:18. 2004
    ..The aim of this work was to determine the effect of human milk proteins on the colonization potential of Shigella dysenteriae, S. flexneri and S. sonnei...
  37. ncbi Purification and crystallization of Shiga toxin from Shigella dysenteriae
    Y V Kozlov
    W A Engelhardt Institute of Molecular Biology, Moscow, Russia
    J Mol Biol 232:704-6. 1993
    The protein toxin produced by Shigella dysenteriae consists of one enzymatically active A subunit of 293 amino acid residues and five B subunits of 69 amino acid residues that are involved with cell attachment...
  38. ncbi Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1
    J D Klena
    Department of Microbiology, Arizona State University, Tempe 85287
    Mol Microbiol 9:393-402. 1993
    A plasmid that included both an 8.9 kb chromosomal DNA insert containing genes from the rfb cluster of Shigella dysenteriae 1 and a smaller insert containing the rfp gene from a S...
  39. ncbi The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxin
    - Kozlov YuV
    Institute of Molecular Biology, USSR Academy of Sciences, Moscow
    Gene 67:213-21. 1988
    Nucleotide(nt) sequences were determined for the toxin (SHT) operon present in the chromosome of Shigella dysenteriae 1 and for the shiga-like toxin (SLT) operon found in the lambdoid phage H30 genome...
  40. ncbi Shiga toxin-encoding bacteriophages--genomes in motion
    Sylvia Herold
    Institut fur Medizinische Mikrobiologie und Hygiene, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, D 01037 Dresden, Germany
    Int J Med Microbiol 294:115-21. 2004
    ..Stx are mainly produced by Escherichia coli isolated from human and non-human sources, Shigella dysenteriae type 1, and sporadically, by Citrobacter freundii, Enterobacter cloacae and Shigella flexneri...
  41. ncbi Spontaneous tandem amplification and deletion of the shiga toxin operon in Shigella dysenteriae 1
    M A McDonough
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Microbiol 34:1058-69. 1999
    Only one species of Shigella, Shigella dysenteriae 1, has been demonstrated to produce Shiga toxin (Stx). Stx is closely related to the toxins produced by Shiga toxin-producing Escherichia coli (STEC)...
  42. pmc The Shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins
    Rembert Pieper
    Pathogen Functional Genomics Resource Center, J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    Proteomics 9:5029-45. 2009
    b>Shigella dysenteriae serotype 1 (SD1) causes the most severe form of epidemic bacillary dysentery...
  43. ncbi Epidemic strain Shigella dysenteriae Type 1 Dt66 encodes several drug resistances by chromosome
    Dipak Kumar Hens
    National Institute of Cholera and Enteric Diseases, Beliaghata Kolkata, India
    Arch Med Res 36:399-403. 2005
    Multiple antibiotic-resistant strains of Shigella dysenteriae type 1 were isolated from an epidemic in West Bengal, India (1984). During the past two decades, much attention was given to reevaluation of treatment recommendations...
  44. pmc Construction, characterization, and animal testing of WRSd1, a Shigella dysenteriae 1 vaccine
    Malabi M Venkatesan
    Department of Enteric Infections, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Infect Immun 70:2950-8. 2002
    WRSd1 is a Shigella dysenteriae 1 vaccine containing deletions of the virG(icsA) gene required for intercellular spreading and a 20-kb chromosomal region encompassing the Shiga toxin genes (stxAB). WRSd1 was constructed from S...
  45. ncbi Structural and genetic evidence that the Escherichia coli O148 O antigen is the precursor of the Shigella dysenteriae type 1 O antigen and identification of a glucosyltransferase gene
    Lu Feng
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa Street, TEDA, Tianjin 300457, P R China
    Microbiology 153:139-47. 2007
    b>Shigella dysenteriae type 1 is the most virulent serotype of Shigella. Enterotoxigenic Escherichia coli O148 is pathogenic and can cause diarrhoea. The following structure was established for the tetrasaccharide repeating unit of the E...
  46. ncbi Altered expression of MUC2 and MUC5AC in response to Shigella infection, an in vivo study
    Prakash Radhakrishnan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
    Biochim Biophys Acta 1770:884-9. 2007
    ..This in vivo study brings new insights into the molecular pathogenesis of Shigellosis and new potential therapeutic targets for Shigellosis...
  47. ncbi Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent
    Avijit Ray
    Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700010, West Bengal, India
    Mol Immunol 41:1167-75. 2004
    Porin of Shigella dysenteriae type 1 increased the mRNA levels for Toll-like receptor (TLR) 2 and TLR6 by 1.5- and 2...
  48. ncbi A novel serovar of Shigella dysenteriae from patients with diarrhoea in Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 56:654-8. 2007
    ..All were nonlactose fermenters, with an identical biochemical pattern typical of Shigella dysenteriae. They were classified as invasive since they harboured the 140 MDa invasive plasmid, were able to bind ..
  49. ncbi Variation in the Shiga toxin region of 20th-century epidemic and endemic Shigella dysenteriae 1 strains
    Karla M Greco
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Infect Dis 190:330-4. 2004
    The Shiga toxin (Stx) region of Shigella dysenteriae 1 lies on a defective prophage homologous to lambdoid bacteriophages in Stx-producing Escherichia coli. S...
  50. ncbi A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France
    Véronique Houdouin
    Services de Microbiologie, Hopital Robert Debre, Paris, France
    Clin Infect Dis 38:e96-9. 2004
    We report a cluster of pediatric diarrhea due to Shigella dysenteriae serotype 1 involving 11 children in France, including the index case, who had returned from Senegal. Child-to-child transmission was documented by ribotyping...
  51. ncbi Characterization of the periplasmic heme-binding protein shut from the heme uptake system of Shigella dysenteriae
    Suntara Eakanunkul
    Department of Pharmaceutical Sciences, School of Pharmacy, 20 Penn Street, University of Maryland, Baltimore, Maryland 21201, USA
    Biochemistry 44:13179-91. 2005
    ..spectroscopic and mutational study of the first purified periplasmic heme-binding protein (PBP), ShuT from Shigella dysenteriae. On the basis of sequence identity, the ShuT protein is most closely related to the class of PBPs typified ..
  52. ncbi Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone
    Philippe J Guerin
    Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
    Lancet 362:705-6. 2003
    ..b>Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases...
  53. pmc Transposition in Shigella dysenteriae: isolation and analysis of IS911, a new member of the IS3 group of insertion sequences
    M F Prere
    Centre de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, Toulouse, France
    J Bacteriol 172:4090-9. 1990
    Twenty-nine clear-plaque mutants of bacteriophage lambda were isolated from a Shigella dysenteriae lysogen...
  54. pmc In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism
    Srilatha Kuntumalla
    Pathogen Functional Genomics Resource Center, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Microbiol 11:147. 2011
    b>Shigella dysenteriae serotype 1 (SD1) causes the most severe form of epidemic bacillary dysentery...
  55. pmc Synthesis, characterization, and clinical evaluation of conjugate vaccines composed of the O-specific polysaccharides of Shigella dysenteriae type 1, Shigella flexneri type 2a, and Shigella sonnei (Plesiomonas shigelloides) bound to bacterial toxoids
    D N Taylor
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Washington, D C 20307 5100
    Infect Immun 61:3678-87. 1993
    ..Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). The O-specific polysaccharides (O-SPs) of Shigella dysenteriae type 1, S. flexneri type 2a, and S. sonnei were covalently bound to carrier proteins...
  56. pmc A piglet model of acute gastroenteritis induced by Shigella dysenteriae Type 1
    Kwang Il Jeong
    Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA
    J Infect Dis 201:903-11. 2010
    ..The lack of a standardized laboratory animal model that mimics key aspects of human shigellosis remains a major obstacle to addressing questions about pathogenesis, screening therapeutics, and evaluation of vaccines...
  57. ncbi Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats
    Guhapriya Moorthy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India
    Nutrition 25:350-8. 2009
    ..Recently we reported the protective role of Lactobacillus rhamnosus and Lactobacillus acidophilus during Shigella dysenteriae 1 infection. Nevertheless, investigations on the membrane-stabilizing effect of L. rhamnosus and L...
  58. ncbi Shiga toxins and apoptosis
    Rama P Cherla
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    FEMS Microbiol Lett 228:159-66. 2003
    The enteric pathogens Shigella dysenteriae serotype 1 and Shiga toxin-producing Escherichia coli (STEC) cause bloody diarrheal diseases that may progress to life-threatening extraintestinal complications. Although the S...
  59. ncbi Emergence of multidrug-resistant Shigella dysenteriae type 1 causing sporadic outbreak in and around Kolkata, India
    D Dutta
    J Health Popul Nutr 21:79-80. 2003
  60. ncbi Structure of the Shigella dysenteriae 7 O antigen gene cluster and identification of its antigen specific genes
    Lu Feng
    College of Life Sciences, Nankai University, Tianjin, China
    Microb Pathog 36:109-15. 2004
    Shigella strains are human pathogens. The O antigen gene cluster of Shigella dysenteriae O7 was sequenced and analyzed...
  61. pmc Shigella spp. surveillance in Indonesia: the emergence or reemergence of S. dysenteriae
    D Subekti
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    Emerg Infect Dis 7:137-40. 2001
    ..S. dysenteriae has reemerged in Bali, Kalimantan, and Batam and was detected in Jakarta after a hiatus of 15 years...
  62. ncbi Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution
    M E Fraser
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Nat Struct Biol 1:59-64. 1994
    b>Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins...
  63. pmc RyhB, an iron-responsive small RNA molecule, regulates Shigella dysenteriae virulence
    Erin R Murphy
    University of Texas at Austin, Section of Molecular Genetics and Microbiology, 1 University Station A5000, Austin, TX 78712, USA
    Infect Immun 75:3470-7. 2007
    ..We show that the sRNA RyhB suppresses several virulence-associated phenotypes of Shigella dysenteriae, a causative agent of bacillary dysentery in humans. The virulence genes repressed by S...
  64. ncbi Multidrug-resistant Shigella dysenteriae type 1 in south Asia
    S K Bhattacharya
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
    Lancet Infect Dis 3:755. 2003
  65. ncbi Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial
    Odile Launay
    Universite Paris Descartes, INSERM, Assistance Publique Hopitaux de Paris, CIC de Vaccinologie Cochin Pasteur CIC BT505, Groupe Hospitalier Cochin Saint Vincent De Paul, Paris, France
    Vaccine 27:1184-91. 2009
    SC599 vaccine is a live Shigella dysenteriae 1 strain attenuated by deletion of invasion [icsA], iron chelation [ent, fep] and shiga toxin A subunit [stxA] genes...
  66. pmc Epidemic dysentery caused by Shigella dysenteriae type 1: a sentinel site surveillance of antimicrobial resistance patterns in Burundi
    D Engels
    Programme for the Control of Diarrhoeal Diseases, Belgian Technical Cooperation, Burundi
    Bull World Health Organ 73:787-91. 1995
    ..the results of a nationwide, health-centre based, sentinel site survey to check the drug resistance of Shigella dysenteriae type 1 (Sd1), the causal organism of such epidemics. Shigella spp...
  67. ncbi Epidemic Shigella dysenteriae type 1 in Burundi: panresistance and implications for prevention
    A A Ries
    Foodborne and Diarrheal Diseases Branches, Centers for Disease Control and Prevention, Atlanta, Georgia
    J Infect Dis 169:1035-41. 1994
    An epidemic of Shigella dysenteriae type 1 infections has affected Africa since 1979. Reported dysentery cases increase sharply in Burundi during September through December...
  68. ncbi Genetic relatedness of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated in south Asia
    Kaisar A Talukder
    Enteric Microbiology Laboratory, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Antimicrob Chemother 54:730-4. 2004
    The aim of the present study was to determine the clonal relationships of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated from south Asia, and S. dysenteriae 1 strains associated with epidemics in 1978, 1984 and 1994.
  69. ncbi Case management of a multidrug-resistant Shigella dysenteriae serotype 1 outbreak in a crisis context in Sierra Leone, 1999-2000
    P J Guerin
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trans R Soc Trop Med Hyg 98:635-43. 2004
    ..b>Shigella dysenteriae serotype 1 was isolated from the early cases. The overall attack rate was 7...
  70. ncbi [An outbreak of Shigella dysenteriae type 1 dysentery in a refugee camp in Rwanda]
    C Paquet
    , Paris, France
    Sante 5:181-4. 1995
    ..We describe the outbreak of dysentery due to Shigella dysenteriae type 1 (Sd1) that developed in Nzangwa, a camp hosting some 20,000 Burundese refugees...
  71. ncbi Multiple copies of iso-insertion sequences of IS1 in Shigella dysenteriae chromosome
    H Ohtsubo
    Nature 292:640-3. 1981
  72. pmc Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in Quinolone-resistant Shigella dysenteriae serotype 1 clinical isolates from Kolkata, India
    Shanta Dutta
    Antimicrob Agents Chemother 49:1660-1. 2005
  73. ncbi Low risk of hemolytic uremic syndrome after early effective antimicrobial therapy for Shigella dysenteriae type 1 infection in Bangladesh
    Michael L Bennish
    Africa Centre for Health and Population Studies, Mtubatuba, South Africa
    Clin Infect Dis 42:356-62. 2006
    ..b>Shigella dysenteriae type 1 also expresses Stx...
  74. ncbi Risk areas and neighborhood-level risk factors for Shigella dysenteriae 1 and Shigella flexneri
    Michael Emch
    University of North Carolina at Chapel Hill, Geography and CPC 308 Saunders Hall, Campus Box 3220, Chapel Hill, NC 27599, USA
    Health Place 14:96-105. 2008
    ..1 million deaths in the developing world. Two species of the causative agent, Shigella dysenteriae 1 and Shigella flexneri, are responsible for acute diarrheal illness...
  75. ncbi Adherence of Shigella dysenteriae 1 to human colonic mucin
    P S Sudha
    Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai-600 025, India
    Curr Microbiol 42:381-7. 2001
    ..Although invasion is the ultimate event, a preceding step is adherence. Shigella dysenteriae 1 preferentially adhered to colonic mucin and not to small intestinal mucin...
  76. pmc Using European travellers as an early alert to detect emerging pathogens in countries with limited laboratory resources
    Philippe J Guerin
    Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
    BMC Public Health 7:8. 2007
    ..We present the results of a case study using reported cases of Shigella dysenteriae serotype 1 (Sd1) in European travellers to detect "events" of Sd1, related to either epidemic cases or ..
  77. ncbi [Investigation of a shigellosis outbreak in a rural zone of Senegal]
    A Diallo
    Centre IRD, BP 1386, Dakar Hann, Senegal
    Sante 11:217-9. 2001
    ..The identification of the SD1 serotype confirmed its involvement in the outbreak of shigellosis. The exact role of S. flexneri in shigellosis epidemics should be further studied...
  78. ncbi Differential expression of ompC and ompF in multidrug-resistant Shigella dysenteriae and Shigella flexneri by aqueous extract of Aegle marmelos, altering its susceptibility toward beta-lactam antibiotics
    Subramaniya Bharathi Raja
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu 600025, India
    Diagn Microbiol Infect Dis 61:321-8. 2008
    ..The present study exemplifies the susceptibility of beta-lactam-resistant Shigella dysenteriae and Shigella flexneri toward beta-lactam antibiotics, when grown in the presence of aqueous extract of A...
  79. ncbi Shigella dysenteriae type 1 with reduced susceptibility to fluoroquinolones
    K Sarkar
    Lancet 361:785. 2003
  80. pmc Identification of shuA, the gene encoding the heme receptor of Shigella dysenteriae, and analysis of invasion and intracellular multiplication of a shuA mutant
    M Mills
    Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin 78712, USA
    Infect Immun 65:5358-63. 1997
    shuA encodes a 70-kDa outer membrane heme receptor in Shigella dysenteriae. Analysis of the shuA DNA sequence indicates that this gene encodes a protein with homology to TonB-dependent receptors of gram-negative bacteria...
  81. pmc Multidrug-resistant Shigella dysenteriae type 1: forerunners of a new epidemic strain in eastern India?
    Dipika Sur
    Emerg Infect Dis 9:404-5. 2003
  82. ncbi Fluoroquinolone-resistant Shigella dysenteriae type 1 in northeastern Bangladesh
    A Naheed
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet Infect Dis 4:607-8. 2004
  83. ncbi [Shigella dysenteriae strains possessing a new serovar (204/96) isolated from imported diarrheal cases in Japan]
    S Matsushita
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 72:499-503. 1998
    ..These strains had the typical biochemical characteristics of Shigella dysenteriae, and were biochemically identical...
  84. ncbi Survival of Shigella dysenteriae type 1 on fomites
    M S Islam
    ICDDR, B: Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Health Popul Nutr 19:177-82. 2001
    ..The present study was carried out to detect VBNC Shigella dysenteriae type 1 on various fomites by direct viable counting, polymerase chain reaction (PCR), and fluorescent ..
  85. pmc Phosphate regulon in members of the family Enterobacteriaceae: comparison of the phoB-phoR operons of Escherichia coli, Shigella dysenteriae, and Klebsiella pneumoniae
    T Y Lee
    Department of Experimental Chemotherapy, Osaka University, Japan
    J Bacteriol 171:6593-9. 1989
    The structure and function of the phoB and phoR genes of Shigella dysenteriae strains and Klebsiella pneumoniae, which are involved in regulation of the phosphate regulon, were analyzed...
  86. pmc Molecular and phenotypic characterization of potentially new Shigella dysenteriae serotype
    R S Coimbra
    , INSERM U389, Institut Pasteur, Paris, France
    J Clin Microbiol 39:618-21. 2001
    ..but all of them agglutinated in the presence of antisera to a previously described potentially new Shigella dysenteriae serotype (represented by strain 96-204) primarily isolated from stool cultures of imported diarrheal cases ..
  87. ncbi Haemolytic uraemic syndrome due to ciprofloxacin-resistant Shigella dysenteriae serotype 1
    Neelam Taneja
    Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh 160012, India
    J Med Microbiol 54:997-8. 2005
    A case of haemolytic uraemic syndrome following dysentery due to ciprofloxacin-resistant Shigella dysenteriae serotype 1 is reported for the first time. The increasing resistance of S...
  88. ncbi Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator
    D Islam
    Laboratory Sciences Division, International Center for Diarrhoeal Disease Research, 1000 Dhaka, Bangladesh
    Nat Med 7:180-5. 2001
    ..Analyses of bacterial molecules causing the downregulation indicate Shigella plasmid DNA as one mediator...
  89. ncbi Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, Baltimore, 685 West Baltimore Street, MD 21201, USA
    Vaccine 24:3727-34. 2006
    ..These studies demonstrate the potential of the use of mixtures of live Shigella derivatives expressing ETEC antigens to serve as an immunogenic multivalent vaccine...
  90. ncbi [Isolation of provisional serovars of Shigella in diarrheal cases of tourists]
    Y Ueda
    Kansai Airport Quarantine Station
    Kansenshogaku Zasshi 75:1025-9. 2001
    ..2%). 5) Twenty-three of the Shigella strains (95.8%) of the provisional serovars were resistant to two or more drugs tested (SM, CP, TC, KM, ABPC, NA, and OFLX). The most predominant drug resistance pattern was SM. CP. TC. ABPC...
  91. ncbi Isolation and characterization of provisional serovar Shigella boydii E16553 from diarrhoeal patients in Bangladesh
    M Ansaruzzaman
    International Center for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 54:477-80. 2005
    In previous studies with strains of the Shigella dysenteriae provisional serovars E22383 and E23507 from diarrhoeal stools from patients in Bangladesh, two strains of Shigella species were identified as Shigella boydii provisional serovar ..
  92. ncbi Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka, 1000, Bangladesh
    Curr Microbiol 52:108-11. 2006
    ..In fluoroquinolone-resistant strains, double mutations (Ser83-->Leu, Asp87-->Asn or Gly) and a single mutation (Ser80-->Ile) were detected in the QRDRs of gyrA and parC, respectively...
  93. ncbi Differences in perception of dysentery and enteric fever and willingness to receive vaccines among rural residents in China
    Xinguang Chen
    Prevention Research Center, The Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 4201 St Antoine Street UHC 6D, Detroit, MI 48201, USA
    Vaccine 24:561-71. 2006
    ..While vaccines offer great potential in controlling these diseases, greater understanding of factors influencing acceptance of vaccines is needed to create effective enteric disease control programs in rural China...
  94. ncbi [A provisional serovar of Shigella dysenteriae isolated in Japan from travellers' diarrhea]
    N Hiruta
    Yokosuka City Institute of Public Health
    Kansenshogaku Zasshi 65:181-4. 1991
    A bacterial strain was isolated that possessed the biochemical characteristics of Shigella dysenteriae but did not belong to any of the established S...
  95. ncbi Vaccine potential for inactivated shigellae
    Manuel Osorio
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852 1448, United States
    Vaccine 25:1581-92. 2007
    ..These in vivo and in vitro data indicate that inactivated shigellae retain the ability to interact effectively with key antigen presenting cells and induce protective immune responses in mice...
  96. ncbi Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh
    J M van den Broek
    Academical Medical Centre, University of Amsterdam, The Netherlands
    J Health Popul Nutr 23:259-65. 2005
    ..lt;60% of median of the National Center for Health Statistics), with a positive stool culture for Shigella dysenteriae type 1 or S...
  97. ncbi Distribution and antibiotic susceptibility of Shigella isolates in Bangui, Central African Republic
    Raymond Bercion
    Institut Pasteur de Bangui, Bangui, Central African Republic
    Trop Med Int Health 13:468-71. 2008
    ..Of the 155 Shigella isolated, Shigella flexneri (51%) and Shigella dysenteriae (30%) were the most common and the most resistant to usual antibiotics, including amoxicillin, ..
  98. ncbi Activities of aqueous extracts of Mallotus oppositifolium on Shigella dysenteriae A1-induced diarrhoea in rats
    René Kamgang
    General Ednocrinology and Metabolism Systems, GEMS, Laboratory of Animal Physiology, University of Yaounde I, Centre Pasteur of Cameroon, Yaounde, Cameroon
    Clin Exp Pharmacol Physiol 33:89-94. 2006
    ..2. Shigella dysenteriae A(1) (Sd1)-induced diarrhoeal rats were obtained by oral administration of increasing densities of the Sd1 ..
  99. ncbi Antimicrobial susceptibility of Shigella flexneri and S. dysenteriae isolated from stool specimens of patients with bloody diarrhoea in Mwanza, Tanzania
    M M Temu
    National Institute for Medical Research, Mwanza Research Centre, P O Box 1462, Mwanza, Tanzania
    Tanzan Health Res Bull 9:186-9. 2007
    ..These findings suggest that there is a need to carry out extensive susceptibility studies in different parts of the country with view of re-appraising the current guidelines for management of bloody diarrhoea in Tanzania...
  100. ncbi [Place and resistance of epidemic strains of Shigella dysenteriae-1 isolated at the Fann Hospital from 1995 to 1999]
    A I Sow
    Laboratoire de Bacteriologie, CHU de Fann, Dakar
    Dakar Med 47:234-8. 2002
    b>Shigella dysenteriae-1 (S.d-1) takes a more and more important place in intertropical countries, with multiresistant strains to antibiotics. the objectives of the study is to determine the prevalence of S...
  101. ncbi The catalase reaction of Shigella species and its use in rapid screening for epidemic Shigella dysenteriae type 1
    J A Karas
    Department of Medical Microbiology, Medical School Campus, University of KwaZulu Natal, Private Bag 7, Congella, Durban, 4013, South Africa
    Ann Trop Med Parasitol 101:79-84. 2007
    As epidemic dysentery caused by Shigella dysenteriae type 1 is associated with high mortality, early identification of outbreaks is important. Since S...

Research Grants31

  1. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..One serotype, Shigella dysenteriae type 1 (S...
  2. Structure-Function of the Shigella dysenteriae heme uptake operon (shu)
    Angela Wilks; Fiscal Year: 2012
    ..Heme utilization by S. dysenteriae is required for virulence and characterization of heme uptake and metabolism may provide novel therapeutic targets for drug development. ..
  3. Bioluminescent reporter phage for the diagnostic detection of shigellosis
    David A Schofield; Fiscal Year: 2013
    ..there is a global rise in the occurrence of muti-drug resistant isolates, such as the epidemic and pandemic Shigella dysenteriae type 1 strain...
  4. Form and Function of Tandem Duplicate Small RNA Molecules in Shigella dysenteriae
    Erin R Murphy; Fiscal Year: 2013
    ..The resulting combination of skills and experience will position students well to contribute to the rapidly advancing fields of ribo-regulation in pathogenic bacteria, commensal bacteria and eukaryotic systems. ..
  5. Bacterial heme transport and hemoglobin expression
    Douglas Henderson; Fiscal Year: 2009
    ..indicated that this hypothesis is valid and that heme transport systems from Plesiomonas shigelloides and Shigella dysenteriae are best suited for this work. "One plasmid" systems were created which contain P...
  6. SHIGA-LIKE TOXIN OF ESCHERICHIA COLI
    ALISON O BRIEN; Fiscal Year: 1991
    ..SLT-II are antigenically distinct members of a family of cytotoxins that are related to the Shiga toxin of Shigella dysenteriae 1...
  7. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..produce potent protein toxins named Shiga-like toxins (Stxs) because of their relatedness to Shiga toxin of Shigella dysenteriae. In addition, most EHEC share the ability to adhere intimately to intestinal epithelial cells by "attaching ..
  8. PATHOGENESIS & INTERVENTION STRATEGIES IN HEMORRHAGIC CO
    Peter Bloom; Fiscal Year: 1999
    ..of his interest in hemolytic uremic syndrome (HUS) stemming from his documentation of an outbreak of Shigella dysenteriae in Souther Africa, Dr...
  9. Identification of the ribosomal target of Shiga-like toxins
    NILGUN TUMER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Infections with Shigella dysenteriae, producing Shiga toxin and Diarrheagenic E. coli, producing Shiga-like toxins (Stx) are responsible for widespread disease and death...
  10. GENETIC AND BIOCHEMICAL ANALYSES OF SHIGA-LIKE TOXINS
    Stephen Calderwood; Fiscal Year: 1993
    ..Shiga toxin from Shigella dysenteriae 1 and Shiga-like toxin (SLT) from Escherichia coli are cytotoxic proteins important in diarrhea and other ..
  11. INTERVENTIONAL STRATEGIES FOR HEMORRHAGIC COLITIS
    Edgar Boedeker; Fiscal Year: 2000
    ..toxins which are referred to as Shiga-like toxins (SLTs) because of their relatedness to shiga toxin of shigella dysenteriae. Most EHEC share the ability to adhere intimately to intestinal epithelial cells by ~attaching and effacing~..
  12. THE CLONAL NATURE OF CYTOTOXIGENIC E. COLI
    THOMAS WHITTAM; Fiscal Year: 1992
    ..cytotoxins -- called Shiga-like toxins (SLTs) because of their functional similarity to Shiga toxin of Shigella dysenteriae - appears to play an important role in pathogenesis...
  13. THE CLONAL NATURE OF CYTOTOXIGENIC E. COLI
    THOMAS WHITTAM; Fiscal Year: 1991
    ..cytotoxins -- called Shiga-like toxins (SLTs) because of their functional similarity to Shiga toxin of Shigella dysenteriae - appears to play an important role in pathogenesis...
  14. PATHOGENIC MECHANISMS OF SHIGA AND SHIGA LIKE TOXINS
    VERNON TESH; Fiscal Year: 1999
    Infections with Shiga toxin-producing Shigella dysenteriae type I or Shiga-like toxin-producing E. coli cause outbreaks of dysenteric disease which continue to be a major cause of morbidity and mortality in maid parts of the world...
  15. A Multiplex, Point-of-Care Test for Enteric Pathogens
    Bernhard Weigl; Fiscal Year: 2007
    ..2. Develop a multiplex NA amplification, lab-on-card platform for rapid identification of Shigella dysenteriae, Shigella toxin-producing Escherichia coli, Campylobacter jejuni, and Salmonella species simultaneously ..
  16. Investigation of iron acquisition genes in Sodalis glossinidius using new tools.
    Laura Runyen Janecky; Fiscal Year: 2009
    ..the putative Sodalis hemS and achromobactin genes will be verified by using the Sodalis genes to complement Shigella dysenteriae and E. coli strains that carry mutations in similar genes...
  17. Analysis of a Shigella dysenteriae Fe regulated promoter
    Erin Murphy; Fiscal Year: 2005
    ..A complete understanding of Fe acquisition, including the genes and proteins involved, will lead to a fuller appreciation of the strategies employed by Shigella spp. for survival and proliferation within the human host. ..
  18. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    Infections with Shiga toxin (Stx)-producing bacteria Shigella dysenteriae 1 and Escherichia coli cause bloody diarrheal diseases which continue to be a major public health concern in developed and developing countries...
  19. Innate immunity and dendritic cells in cryptosporidiosis
    SAUL R TZIPORI; Fiscal Year: 2010
    ..The proposed studies will provide the basis for understanding the mechanisms of innate immune recognition and response to parasite invasion necessary for future design of vaccines and other methods of interventions. ..
  20. Shigella dysenteriae vaccine construction
    Eileen Barry; Fiscal Year: 2009
    b>Shigella dysenteriae Type 1 is one of the most fearsome of the Category B Priority agents owing to its high infectivity at low doses, severe disease sequelae, and ability to cause explosive epidemics in naive populations...
  21. IMMUNITY TO CRYPTOSPORIDIOSIS IN SIV INFECTED MACAQUES
    Saul Tzipori; Fiscal Year: 2002
    ..An understanding of this mechanism is important for the derivation of immunotherapeutic strategies that may be necessary to control chronic cryptosporidiosis in patients with AIDS. ..
  22. Heme Oxygenase: Structure, Function and Pathogenesis
    Angela Wilks; Fiscal Year: 2008
    ..abstract_text> ..
  23. Conserved pneumococcal protein live-vector vaccine
    Eileen Barry; Fiscal Year: 2007
    ..Typhi live vector strains, and provide preclinical data necessary for advancing promising candidates into clinical trials. ..
  24. Induction of Tissue Factor by Patient Sera in HUS
    Eric Grabowski; Fiscal Year: 2007
    ..A key additional feature of this proposal is the use of our newly formed collaborative group of pediatric nephrologists to facilitate patient recruitment [unreadable] [unreadable]..
  25. Specific Human Monoclonal Antibodies for HUS Prophylaxis
    Saul Tzipori; Fiscal Year: 2007
    ..This is not a hypothesis-driven proposal, but an essential segment for the characterization of a promising therapy for HUS, against which currently there is no effective treatment. ..
  26. Heme Acquisition in Shigella Dysenteriae.
    Angela Wilks; Fiscal Year: 2005
    ..Once an understanding of the mechanism of heme transport in bacterial pathogens has been established the stage will be set for future design of selective inhibitors of heme transport. ..
  27. PIG MODEL FOR E BIENEUSI
    Saul Tzipori; Fiscal Year: 2002
    ..Given the cost and nature of the simian SIV model it is unlikely this model would serve the same function. ..
  28. RECOMBINANT SHIGA-TOXIN-SPECIFIC HUMAN ANTIBODIES
    Saul Tzipori; Fiscal Year: 2004
    ..abstract_text> ..
  29. Functional Tissue Factor on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2004
    ....
  30. Generation of Reagents for E. bieneusi Genome Sequencing
    Saul Tzipori; Fiscal Year: 2003
    ..The outcome of this proposal will lead to a submission of a full proposal to sequence the EB genome. ..
  31. Studies on Cryptosporidium parvum Type 1
    Saul Tzipori; Fiscal Year: 2006
    ..The third aim investigates the extent of genetic variation and exchange within and between the two types of C. parvum to determine whether they belong to one or two species. ..