gram positive cocci

Summary

Summary: Coccus-shaped bacteria that retain the crystal violet stain when treated by Gram's method.

Top Publications

  1. pmc Comparison of BACTEC PLUS blood culture media to BacT/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics
    Diane Flayhart
    The Johns Hopkins Hospital, Microbiology Laboratory, Baltimore, MD 21287, USA
    J Clin Microbiol 45:816-21. 2007
  2. ncbi Potential role of anaerobic cocci in impaired human wound healing
    Ivan B Wall
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 10:346-53. 2002
  3. pmc Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen
    Inga Maria Frick
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Mol Microbiol 70:695-708. 2008
  4. pmc Performance of the new VITEK 2 GP card for identification of medically relevant gram-positive cocci in a routine clinical laboratory
    Guido Funke
    Department of Medical Microbiology and Hygiene, Gärtner and Colleagues Laboratories, Hoyerstrasse 51, D 88250 Weingarten, Germany
    J Clin Microbiol 43:84-8. 2005
  5. ncbi SufA--a novel subtilisin-like serine proteinase of Finegoldia magna
    Christofer Karlsson
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, BMC, B14, 221 84 Lund, Sweden
    Microbiology 153:4208-18. 2007
  6. ncbi Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program
    Alan H Mutnick
    Pharmacology, The JONES Group JMI Laboratories, North Liberty, IA 52317 9258, USA
    Ann Pharmacother 37:769-74. 2003
  7. pmc Evaluation of the Merlin MICRONAUT system for rapid direct susceptibility testing of gram-positive cocci and gram-negative bacilli from positive blood cultures
    Nele Wellinghausen
    Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Ulm, Germany
    J Clin Microbiol 45:789-95. 2007
  8. ncbi Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Gary J Moet
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 57:7-13. 2007
  9. ncbi The Meropenem Yearly Susceptibility Test Information Collection antimicrobial susceptibility program in Spain: a 5-year analysis
    Alvaro Pascual
    Hospital Virgen Macarena Seville, 41080 Seville, Spain
    Diagn Microbiol Infect Dis 57:195-200. 2007
  10. pmc As a bacterial culture medium, citrated sheep blood agar is a practical alternative to citrated human blood agar in laboratories of developing countries
    F M Russell
    Department of Paediatrics, Centre for International Child Health, University of Melbourne, Melbourne, Australia
    J Clin Microbiol 44:3346-51. 2006

Detail Information

Publications194 found, 100 shown here

  1. pmc Comparison of BACTEC PLUS blood culture media to BacT/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics
    Diane Flayhart
    The Johns Hopkins Hospital, Microbiology Laboratory, Baltimore, MD 21287, USA
    J Clin Microbiol 45:816-21. 2007
    ....
  2. ncbi Potential role of anaerobic cocci in impaired human wound healing
    Ivan B Wall
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 10:346-53. 2002
    ..This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process...
  3. pmc Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen
    Inga Maria Frick
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Mol Microbiol 70:695-708. 2008
    ..Altogether, the data demonstrate that FAF plays an important role in colonization and survival of F. magna in the human host...
  4. pmc Performance of the new VITEK 2 GP card for identification of medically relevant gram-positive cocci in a routine clinical laboratory
    Guido Funke
    Department of Medical Microbiology and Hygiene, Gärtner and Colleagues Laboratories, Hoyerstrasse 51, D 88250 Weingarten, Germany
    J Clin Microbiol 43:84-8. 2005
    ..It is concluded that the new VITEK 2 GP identification card provides reliable results for the identification of GP cocci under routine laboratory conditions...
  5. ncbi SufA--a novel subtilisin-like serine proteinase of Finegoldia magna
    Christofer Karlsson
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, BMC, B14, 221 84 Lund, Sweden
    Microbiology 153:4208-18. 2007
    ..SufA was found to efficiently cleave and inactivate the antibacterial peptide LL-37 and the CXC chemokine MIG/CXCL9, indicating that the enzyme promotes F. magna survival and colonization...
  6. ncbi Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program
    Alan H Mutnick
    Pharmacology, The JONES Group JMI Laboratories, North Liberty, IA 52317 9258, USA
    Ann Pharmacother 37:769-74. 2003
    ..Linezolid has proven to be a first-line therapeutic option for vancomycin-resistant strains. Linezolid clinical trial results and subsequent published case reports cite rare resistance emerging in patients receiving prolonged therapy...
  7. pmc Evaluation of the Merlin MICRONAUT system for rapid direct susceptibility testing of gram-positive cocci and gram-negative bacilli from positive blood cultures
    Nele Wellinghausen
    Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Ulm, Germany
    J Clin Microbiol 45:789-95. 2007
    ..Thereby, it reduces the time to results of blood culture testing and may have a positive impact on patient care...
  8. ncbi Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Gary J Moet
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 57:7-13. 2007
    ..48.0%) when compared with other regions. Continued surveillance of pathogen prevalence and antimicrobial resistance patterns should provide information that is important to improve empiric care particularly in the hospital environment...
  9. ncbi The Meropenem Yearly Susceptibility Test Information Collection antimicrobial susceptibility program in Spain: a 5-year analysis
    Alvaro Pascual
    Hospital Virgen Macarena Seville, 41080 Seville, Spain
    Diagn Microbiol Infect Dis 57:195-200. 2007
    ..There was no significant decrease in susceptibility to the carbapenems throughout the 5-year period. The clinical use of meropenem in 7 Spanish centers did not increase bacterial resistance to this agent in the microorganisms evaluated...
  10. pmc As a bacterial culture medium, citrated sheep blood agar is a practical alternative to citrated human blood agar in laboratories of developing countries
    F M Russell
    Department of Paediatrics, Centre for International Child Health, University of Melbourne, Melbourne, Australia
    J Clin Microbiol 44:3346-51. 2006
    ..CSB MHA may be suitable for use for the susceptibility testing of S. pneumoniae...
  11. ncbi Antibiotic resistance testing of the total implant-associated micro-flora and its pure isolates
    J Karbach
    Department for Oral Surgery, Johannes Gutenberg University Mainz, Mainz, Germany
    Eur J Med Res 12:120-8. 2007
    ..The aim of the present study was to examine antibiotic resistant strains among the implant-associated microorganisms in vitro, first as mixed cultures and again as pure isolates for resistance to one of five antibiotics...
  12. ncbi Linezolid in vitro: mechanism and antibacterial spectrum
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
    J Antimicrob Chemother 51:ii9-16. 2003
    ..Risk factors for selection of resistance include indwelling devices, undrained foci, protracted therapy and underdosage...
  13. ncbi Evaluation of the in vitro activity of daptomycin against 19615 clinical isolates of Gram-positive cocci collected in North American hospitals (2002-2005)
    Michael A Pfaller
    University of Iowa, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 57:459-65. 2007
    ..5, and 1 microg/mL for staphylococci, enterococci, beta-hemolytic streptococci, and viridans group streptococci, respectively, and no significant loss in potency was observed over the period studied...
  14. ncbi Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia in Latin America: frequency of occurrence and antimicrobial susceptibility profile: results from the SENTRY Antimicrobial Surveillance Program (1997-2000)
    Ana C Gales
    Laboratório Especial de Microbiologia Clínica, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 44:301-11. 2002
    ..Our results emphasize the importance of local surveillance programs in correctly guiding empiric therapy and local intervention programs in attempt to reduce antimicrobial resistance...
  15. ncbi Characterization of macrolide resistance in Gram-positive cocci from Colombian hospitals: a countrywide surveillance
    Jinnethe Reyes
    Bacterial Molecular Genetics Unit, Centro de Investigaciones, Universidad El Bosque, Bogota, Colombia
    Int J Infect Dis 11:329-36. 2007
    ..The characterization of macrolide resistance in Gram-positive cocci recovered from Colombian hospitals...
  16. ncbi Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections
    Alasdair P Macgowan
    Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol and North Bristol NHS Trust, Department of Medical Microbiology, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
    J Antimicrob Chemother 51:ii17-25. 2003
    ..In man, t > MIC and AUC/MIC have been related to bacteriological and clinical outcomes. AUC and length of treatment are also related to the risk of thrombocytopenia...
  17. ncbi Antimicrobial activity of nisin against Oenococcus oeni and other wine bacteria
    Beatriz Rojo-Bezares
    Department of Food and Agriculture, Faculty of Science, University of La Rioja, Av Madre de Dios 51, 26006 Logrono, Spain
    Int J Food Microbiol 116:32-6. 2007
    ..It is concluded that appropriate combinations of nisin and metabisulphite could control the growth of spoilage bacteria in wine and therefore allow a decrease in the levels of sulphur dioxide currently used by the wine industry...
  18. ncbi Influence of polysorbate-80 when determining the tigecycline MIC by the reference method
    Ronald N Jones
    Diagn Microbiol Infect Dis 58:145-6. 2007
  19. ncbi Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries
    Gian Carlo Schito
    Institute of Microbiology, Medical School, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    J Antimicrob Chemother 50:7-11. 2002
    ..These data indicate that cefpodoxime represents an appropriate choice in the treatment of community-acquired respiratory tract infection in the three countries surveyed...
  20. pmc Peptoniphilus gorbachii sp. nov., Peptoniphilus olsenii sp. nov., and Anaerococcus murdochii sp. nov. isolated from clinical specimens of human origin
    Yuli Song
    Research Service, VAMedical Center, West Los Angeles, CA 90073, USA
    J Clin Microbiol 45:1746-52. 2007
    ..nov., and Anaerococcus murdochii sp. nov. are WAL 10418(T) (= CCUG 53341(T) = ATCC BAA-1383(T)), WAL 12922(T) (= CCUG 53342(T) = ATCC BAA-1384(T)), and WAL 17230(T) (= CCUG 53340(T) = ATCC BAA-1385(T)), respectively...
  21. ncbi Microbiology of postoperative infections
    Antonio Toniolo
    Laboratory of Microbiology and Virology, University of Insubria and Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Surg Infect (Larchmt) 7:S13-6. 2006
    ..Clinical failure of antibiotic treatment often is associated with increasing drug resistance...
  22. ncbi Antimicrobial susceptibility of gram-positive bacteria isolated from European medical centres: results of the Daptomycin Surveillance Programme (2002-2004)
    H S Sader
    JMI Laboratories, North Liberty, IA 52317, USA
    Clin Microbiol Infect 12:844-52. 2006
    ..This novel lipopeptide (daptomycin) appears to be an excellent alternative therapeutic option for serious infections caused by multidrug-resistant gram-positive organisms isolated in Europe...
  23. pmc Acute cholecystitis accompanied by acute pancreatitis potentially caused by Dolosigranulum pigrum
    Jung Chung Lin
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, National Defence Medical Center, Taipei, Taiwan, Republic of China
    J Clin Microbiol 44:2298-9. 2006
    ..The patient recovered without sequelae after treatment with appropriate antibiotics for two weeks...
  24. ncbi Thirty-day mortality of nosocomial systemic bacterial infections according to antibiotic susceptibility in an 800-bed teaching hospital in France
    D Guillemot
    Centre de Ressource en Biostatistiques, Epidémiologie et Pharmacoépidémiologie CeRBEP appliquées aux Maladies Infectieuses, Institut Pasteur, Paris, France
    Clin Microbiol Infect 11:502-4. 2005
    ..The increased mortality rate associated with antibiotic resistance was observed for all bacterial species with the exception of Gram-positive cocci, and remained significant or near-significant regardless of the hospital ward...
  25. ncbi Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of gram-positive catheter-related bacteraemia
    Nathan P Wiederhold
    The University of Houston College of Pharmacy, Houston, TX 77030, USA
    J Antimicrob Chemother 55:792-5. 2005
    ..The aim of this study was to compare the activity of linezolid and vancomycin in an in vitro pharmacodynamic model to assess potential differences in activity against biofilm-embedded organisms...
  26. ncbi Cefdinir: an oral alternative to parenteral cephems
    Archana Chatterjee
    Department of Pediatrics, Creighton University Medical Center, Omaha, NE 68131, USA
    Diagn Microbiol Infect Dis 51:259-64. 2005
    ..These data support clinical consideration of cefdinir as an alternative to parenteral cephems in infections where adequate tissue levels can be safely assured...
  27. ncbi Blood culture Gram stain and clinical categorization based empirical antimicrobial therapy of bloodstream infection
    Timo Hautala
    Department of Internal Medicine, Oulu University Hospital, P O Box 5000, FIN 90014 Oulu, Finland
    Int J Antimicrob Agents 25:329-33. 2005
    ..We conclude that Gram stain results of positive blood cultures along with the knowledge of where the infection was acquired, would allow early accurate targeting of antimicrobial therapy for BSI...
  28. pmc In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria
    Eun Jeong Yoon
    Department of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56 1, Shillim 9 Dong, Kwanak gu, Seoul 151 742, Korea
    Antimicrob Agents Chemother 49:2498-500. 2005
    ..78 microg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested...
  29. ncbi Surveillance of linezolid resistance in Germany, 2001-2002
    J Brauers
    Antiinfectives Intelligence GmbH, Bonn, Germany
    Clin Microbiol Infect 11:39-46. 2005
    ..The prevalence of resistance to linezolid was very low in Germany. Organisms reported as linezolid-resistant should be retested, either in the same laboratory with an alternative method or in a reference laboratory...
  30. pmc In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 49:2507-9. 2005
    ..Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline...
  31. ncbi Update on the use of linezolid: a pediatric perspective
    Tina Q Tan
    Northwestern University and Children s Memorial Hospital, Chicago, IL, USA
    Pediatr Infect Dis J 23:955-6. 2004
  32. ncbi Investigation of the susceptibility trends in Japan to fluoroquinolones and other antimicrobial agents in a nationwide collection of clinical isolates: a longitudinal analysis from 1994 to 2002
    Keizo Yamaguchi
    Department of Microbiology, Toho University, School of Medicine, Tokyo 143 8540, Japan
    Diagn Microbiol Infect Dis 52:135-43. 2005
    ..was detected in any of the surveys. The rate of FQ resistance to Pseudomonas aeruginosa isolated from urinary tract and respiratory tract infections was 40%-60% and 15%-25%, respectively...
  33. ncbi Trends in linezolid susceptibility patterns: report from the 2002-2003 worldwide Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) Program
    Tamara R Anderegg
    JMI Laboratories, Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 26:13-21. 2005
    ..63DDD/100 patient days (a 50% increase since 2002), and indicates the important role of hospital hygiene practice in preventing the dissemination of oxazolidinone resistances, should they be detected...
  34. ncbi Place of newer quinolones and rifampicin in the treatment of Gram-positive bone and joint infections
    Frederic Frippiat
    J Antimicrob Chemother 54:1158; author reply 1159. 2004
  35. ncbi New drugs for Gram-positive uropathogens
    F M E Wagenlehner
    Department of Urology, Hospital St Elisabeth, St Elisabeth Strasse 23, D 94315 Straubing, Germany
    Int J Antimicrob Agents 24:S39-43. 2004
    ..The pharmacokinetics and the mode of action of these two antibiotics are discussed together with some clinical data in the context of therapeutic use in patients with complicated UTIs...
  36. ncbi [Clinical study of teicoplanin in the treatment of patients with gram-positive cocci: the Chinese experience]
    Li xian He
    Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Nei Ke Za Zhi 44:337-41. 2005
    ..To evaluate the efficacy and safety of Teicoplanin (TEC) in the treatment of Chinese patients with moderate and severe Gram positive (G(+)) coccus infections...
  37. ncbi Spectrum and potency of dalbavancin tested against 3322 Gram-positive cocci isolated in the United States Surveillance Program (2004)
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 54:149-53. 2006
    ..Dalbavancin wild-type MIC distributions remain unchanged compared with prior sampled years (2002-2003) in the USA...
  38. ncbi A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis
    P B Smith
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Perinatol 26:111-4. 2006
    ..We sought to compare laboratory and clinical parameters of GNR and GPC meningitis in a cohort of term and premature infants...
  39. ncbi Gram-positive cocci infections in intensive care: guide to antibacterial selection
    Francisco Alvarez-Lerma
    Intensive Care Medicine Service, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    Drugs 66:751-68. 2006
    ....
  40. ncbi Bacteraemia--a Sagamu perception
    O A Osinupebi
    Department of Medical Microbiology and Parasitology, College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
    Afr J Med Med Sci 32:311-4. 2003
    ..In conclusion, this study demonstrates the need for all hospitals to monitor the microorganisms causing septicemia so that the clinicians can be alerted to a suitable strategy for blind therapy...
  41. ncbi Trends in linezolid susceptibility patterns in 2002: report from the worldwide Zyvox Annual Appraisal of Potency and Spectrum Program
    James E Ross
    The JONES Group JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 52:53-8. 2005
    ..Rare linezolid-resistant strains were identified in the United States only (0.05% resistance overall)...
  42. doi Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistance
    Keira A Cohen
    Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 29:975-7. 2008
    ..Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone...
  43. ncbi Bacteriology of parapneumonic pleural effusions in an Indian hospital
    Srujana Mohanty
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
    Trop Doct 37:228-9. 2007
    ..27.7%), Pseudomonas aeruginosa (23.9%) and Klebsiella spp. (12.6%). Staphylococcus aureus (9.6%) was the most frequent Gram-positive organism. Most of the pathogens showed resistance to multiple antibiotic agents...
  44. ncbi Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan
    Y T Huang
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taipei, Taiwan
    Clin Microbiol Infect 14:124-9. 2008
    ..Tolerance towards tigecycline was exhibited by 40% of the MRSA isolates, 100% of the MSSA and vancomycin-resistant E. faecalis isolates, and 90% of the vancomycin-resistant E. faecium isolates...
  45. pmc Life-threatening invasive Helcococcus kunzii infections in intravenous-drug users and ermA-mediated erythromycin resistance
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 43:6205-8. 2005
    ..Gram smears of both H. kunzii isolates showed a mixture of gram-positive and gram-negative cocci. The isolate from the first patient, resistant to erythromycin and clindamycin, possessed an ermA gene...
  46. doi Comparative analysis of antimicrobial susceptibility among organisms from France, Germany, Italy, Spain and the UK as part of the tigecycline evaluation and surveillance trial
    A C Rodloff
    Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany
    Clin Microbiol Infect 14:307-14. 2008
    ..The in-vitro activity of tigecycline against both Gram-positive and Gram-negative isolates may make it valuable in the treatment of hospital infections, including those caused by otherwise antimicrobial-resistant organisms...
  47. doi Associated antimicrobial resistance in Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes
    A Wimmerstedt
    Department of Clinical Microbiology, Central Hospital, Vaxjo, Sweden
    Clin Microbiol Infect 14:315-21. 2008
    ....
  48. ncbi Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Diagn Microbiol Infect Dis 62:67-80. 2008
    ..aeruginosa), respectively...
  49. ncbi Strategies for managing today's infections
    Y Carmeli
    Division of Infectious Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Microbiol Infect 14:22-31. 2008
    ..Agents must be highly active, able to penetrate adequately to the site of infection, safe, and well-tolerated...
  50. pmc Accuracy and potential usefulness of triplex real-time PCR for improving antibiotic treatment of patients with blood cultures showing clustered gram-positive cocci on direct smears
    Raymond Ruimy
    Hospital Group Bichat Claude Bernard, Laboratoire de Bacteriologie, 46, rue Henri Huchard, 75018 Paris, France
    J Clin Microbiol 46:2045-51. 2008
    ..The use of RT-PCR would increase treatment effectiveness in patients with staphylococcal bacteremia and reduce the selective pressure created by glycopeptides...
  51. doi Emergence of multidrug resistance in bacteria and impact on antibiotic expenditure at a major army medical center caring for soldiers wounded in Iraq and Afghanistan
    Michael J Zapor
    Department of Medicine, Infectious Disease Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Infect Control Hosp Epidemiol 29:661-3. 2008
    ..Moreover, antibiotic prescribing patterns during this period have changed remarkably and mirror the emergence of these organisms at our institution...
  52. ncbi Urinary tract infection trends in Latin American hospitals: report from the SENTRY antimicrobial surveillance program (1997-2000)
    Ana C Gales
    Division of Infectious Diseases, Universidade Federal de, Sao Paulo, SP, Brazil
    Diagn Microbiol Infect Dis 44:289-99. 2002
    ..Carbapenem-resistant P. aeruginosa, ciprofloxacin-resistant E. coli, ESBL-producing K. pneumoniae constitute serious problem in this geographic region...
  53. ncbi Experience with linezolid therapy in children with osteoarticular infections
    Chih Jung Chen
    Division of Pediatric Infectious Diseases, Department of Pediatrics Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 26:985-8. 2007
    ..The clinical efficacy of this drug has not been previously evaluated for Gram-positive osteoarticular infections in children...
  54. ncbi Use of in vitro susceptibility and pathogen prevalence data to model the expected clinical success rates of tigecycline and other commonly used antimicrobials for empirical treatment of complicated skin and skin-structure infections
    Helio S Sader
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 30:514-20. 2007
    ..1%) and imipenem in Spain (87.7%). Our results suggest that tigecycline represents a viable additional option for the empirical treatment of cSSSI in these countries...
  55. ncbi [Experimental models: interaction of Synercid with other anti-Gram positive agents]
    B Fantin
    INSERM EMI 9933, Paris
    Presse Med 30:XV-XVIII. 2001
    ..aureus infections with a large inoculum and even more so for meti-R resistant strains with a C-MLSB phenotype. Combination with rifampicin would be another possibility, but only for strains not resistant to quinupristin...
  56. ncbi Antimicrobial susceptibility of Gram-positive bacterial isolates from the Asia-Pacific region and an in vitro evaluation of the bactericidal activity of daptomycin, vancomycin, and teicoplanin: a SENTRY Program Report (2003-2004)
    Douglas J Biedenbach
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 30:143-9. 2007
    ..Daptomycin was demonstrated to have excellent in vitro activity when tested against Gram-positive isolates collected from Asia-Pacific countries, including hVISA strains...
  57. ncbi Activities of clindamycin, synercid, telithromycin, linezolid, and mupirocin against Gram-positive coccal strains resistant to erythromycin in Korea
    Ae Ran Kwon
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151742, Korea
    Arch Pharm Res 30:840-3. 2007
    ..Synercid, telithromycin, linezolid and mupirocin were active against streptococci...
  58. ncbi Zyvox Annual Appraisal of Potency and Spectrum Program Results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from 16 countries
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 59:199-209. 2007
    ..Overall, linezolid remained active against 99.88% of tested strains from this global collection...
  59. ncbi Prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters does not affect antimicrobial activity of catheters
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine and Center for Prosthesis Infection, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 60:148-51. 2007
    ..We assessed the in vitro effect of exposing various bacteria to minocycline/rifampicin-impregnated vascular catheters on the antimicrobial activity of the catheters and the antimicrobial susceptibility of tested organisms...
  60. ncbi Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats
    Annette Litster
    School of Veterinary Science, The University of Queensland, Brisbane, Australia
    J Vet Intern Med 21:990-5. 2007
    ..Pradofloxacin is a 3rd generation veterinary fluoroquinolone designed to restrict the emergence of antimicrobial resistance during therapy...
  61. ncbi Two cases of diskitis attributable to anaerobic bacteria in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatrics 107:E26. 2001
    ..Future prospective studies are warranted to elucidate the role of anaerobic bacteria in diskitis in children...
  62. ncbi [Prevention and treatment of febrile neutropenia]
    F Montemurro
    Dipartimento di Scienze Biomediche ed Oncologia Umana, , Italy
    Tumori 83:S15-9. 1997
    ..In the first reports, outpatient treatment has proven to be effective, cost saving and well received by patients, but further studies are needed to accurately define low risk status and the optimal home antibiotic regimens...
  63. ncbi Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Clin Dermatol 9:245-54. 2008
    ..Further clinical studies are needed to determine the efficacy and safety of ceftobiprole and to define its role in patient care...
  64. ncbi [Pharmacokinetic and clinical studies of cefteram pivoxil granule in the pediatric field]
    T Motohiro
    Department of Pediatrics, School of Medicine, Kurume University
    Jpn J Antibiot 42:2023-61. 1989
    ..aureus ranged from 3.13 to 6.25 micrograms/ml except for 1 strain, thus CFTM was equally effective to CEX, but less active than the other drugs tested.(ABSTRACT TRUNCATED AT 400 WORDS)..
  65. ncbi Optimisation of the prevention and treatment of bacterial endocarditis
    K A Taubert
    Department of Science and Medicine, American Heart Association, Dallas, Texas 75231, USA
    Drugs Aging 18:415-24. 2001
    ..For all of the above situations, vancomycin is recommended for the patient allergic to penicillin (or methicillin). Finally, consideration of out-of-hospital therapy in selected patients is discussed...
  66. ncbi Rapid differentiation of Staphylococcus aureus, Staphylococcus epidermidis and other coagulase-negative staphylococci and meticillin susceptibility testing directly from growth-positive blood cultures by multiplex real-time PCR
    Leanne Jukes
    Public Health Wales Microbiology ABM Swansea, Singleton Hospital, Abertawe Bro Morgannwg University Health Board, Swansea, UK
    J Med Microbiol 59:1456-61. 2010
    ....
  67. ncbi Antibiotic resistance patterns of aerobic coryneforms and furazolidone-resistant Gram-positive cocci from the skin surface of the human axilla and fourth toe cleft
    E A Eady
    The Skin Research Centre, Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 46:205-13. 2000
    ..The three unusual macrolide resistance phenotypes may be associated with novel resistance mechanisms...
  68. doi Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Drugs 69:809-31. 2009
    ..Further clinical studies are needed to determine the efficacy and safety of ceftaroline, and to define its role in patient care...
  69. ncbi In vitro susceptibility of gram-positive cocci isolated from skin and respiratory tract to azithromycin and twelve other antimicrobial agents
    C M Mendes
    Fleury Laboratory, Av General Waldomino de Lima 508, Sao Paulo, SP 04344 070, Brazil
    Braz J Infect Dis 5:269-76. 2001
    ....
  70. ncbi Benefit-risk assessment of linezolid for serious gram-positive bacterial infections
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Drug Saf 31:753-68. 2008
    ....
  71. ncbi The role of aminoglycosides in combination with a beta-lactam for the treatment of bacterial endocarditis: a meta-analysis of comparative trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 57:639-47. 2006
    ..The addition of an aminoglycoside to a beta-lactam for the treatment of patients with infective endocarditis has been supported by data from laboratory and animal studies...
  72. ncbi [Microbiological, pharmacokinetic and clinical studies of rokitamycin dry syrup in the pediatric field]
    T Motohiro
    Department of Pediatrics, School of Medicine, Kurume University
    Jpn J Antibiot 41:920-59. 1988
    ..1. The GA-test produced pH values indicating that amounts of gastric acid were mostly either normal or high in 42 of the 43 subjects tested (97.7%), and only one low acid case (2.3%) was observed.(ABSTRACT TRUNCATED AT 400 WORDS)..
  73. ncbi Comparison of a closed (Trach Care MAC) with an open endotracheal suction system in small premature infants
    L Cordero
    Department of Pediatrics, Ohio State University Medical Center, Columbus 43210 1228, USA
    J Perinatol 20:151-6. 2000
    ....
  74. ncbi In vitro activity of LY 333328 against anaerobic gram-positive bacteria
    E Sillerström
    Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    J Chemother 11:90-2. 1999
    ..025-4.0 mg/l; teicoplanin, 0.064-4.0 mg/l; cefoxitin, 0.5-1.0 mg/l; imipenem, 0.016-0.5 mg/l; clindamycin, 0.008-1.0 mg/l; metronidazole, 1.0-4.0 mg/l. LY 333328 had an excellent in vitro activity against anaerobic Gram-positive bacteria...
  75. ncbi Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients
    M N Carrasco
    Intensive Care Unit, Hospital Universitario de la Princesa, Diego de Leon 62, 28006 Madrid, Spain
    Intensive Care Med 30:633-8. 2004
    ..To compare the incidence of catheter colonization and catheter-related bloodstream infections between heparin-coated catheters and those coated with a synergistic combination of chlorhexidine and silver sulfadiazine...
  76. doi [Interpretive reading of the antibiogram in gram positive cocci]
    Carmen Torres
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logrono, Espana
    Enferm Infecc Microbiol Clin 28:541-53. 2010
    ..Glycopeptide-resistant strains of enterococci are uncommon in Spain, but nosocomial outbreaks due to vanA enterococci and case reports due to vanB2 enterococci have been recently reported...
  77. ncbi Correlation of in vitro activities of the fluoroquinolones to their in vivo efficacies
    P B Fernandes
    Anti infective Research, Abbott Laboratories, Abbott Park, IL 60064
    Drugs Exp Clin Res 14:375-8. 1988
    ..aeruginosa in this model. Differences in in vitro potencies were not reflected in in vivo efficacies.(ABSTRACT TRUNCATED AT 250 WORDS)..
  78. ncbi Prospective vancomycin audit in Auckland healthcare hospitals
    D Drinkovic
    Green Lane and National Women s Hospitals, Auckland
    N Z Med J 112:336-9. 1999
    ..The aim of this study was to audit the use of vancomycin in Auckland Healthcare hospitals...
  79. pmc In vivo pharmacodynamic activity of the glycopeptide dalbavancin
    David Andes
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Antimicrob Agents Chemother 51:1633-42. 2007
    ..The free-drug 24-h AUC/MIC targets identified in these studies should be helpful for discerning rational susceptibility breakpoints. The current MIC(90) for the target gram-positive organisms would fall within this value...
  80. ncbi Neonatal septicaemia in Ilorin: bacterial pathogens and antibiotic sensitivity pattern
    A O Mokuolu
    Department of Paediatrics, University of Ilorin Teaching Hospital, Ilorin, Nigeria
    Afr J Med Med Sci 31:127-30. 2002
    ..Between 3 and 7 days of life the Gram positive cocci accounted for 12 (60%) of the 20 isolates while the Gram negative bacilli represented 40%...
  81. ncbi [Usefulness of 7 day therapy with cefluprenam in the management of respiratory tract infections]
    K Shimada
    Department of Internal Medicine, Tokyo Senbai Hospital
    Kansenshogaku Zasshi 71:770-87. 1997
    ..The recurrence was noted in 1.2% (1/82). The bacteriological response rate was 100.0% (32/32) for gram positive cocci, 93.8% (15/16) for gram negative rods and 97.9% (47/48) in total. 2. Adverse drug reactions were noted in 3...
  82. doi Indoor and outdoor airborne bacteria in child day-care centers in Edirne City (Turkey), seasonal distribution and influence of meteorological factors
    Halide Aydogdu
    Food Technology Programme, Trakya University Arda Vocational College, 22030, Edirne, Turkey
    Environ Monit Assess 164:53-66. 2010
    ..Fluctuations in bacterial counts in different seasons were observed...
  83. ncbi Antimicrobial susceptibility of gram-positive bacteria isolated in Brazilian hospitals participating in the SENTRY Program (2005-2008)
    Ana C Gales
    Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Braz J Infect Dis 13:90-8. 2009
    ..Although vancomycin resistance rates in Brazil appears to be relatively low compared to those reported in the USA, VRE has emerged and rapidly disseminated in some Brazilian medical centers...
  84. ncbi Epidemiology of nosocomial pneumonia in infants after cardiac surgery
    Linhua Tan
    Department of Surgical Intensive Care Unit, Affiliated Children s Hospital, School of Medicine, Zhejiang University, No 57 Zhu Gan Xiang, Hangzhou, China 310003
    Chest 125:410-7. 2004
    ..The pattern of nosocomial pneumonia (NP) in infants in a pediatric surgical ICU after cardiac surgery may differ from that seen in adult ICUs...
  85. ncbi [Cerebral abscess and cyanotic congenital heart disease]
    P Guerin
    Service de Cardiologie Pediatrique, Hopital Cardiologique du Haut Leveque, Universite de Bordeaux II, Pessac
    Arch Mal Coeur Vaiss 90:651-4. 1997
    ..They were gram positive cocci, in particular the streptococcus...
  86. pmc StaphPlex system for rapid and simultaneous identification of antibiotic resistance determinants and Panton-Valentine leukocidin detection of staphylococci from positive blood cultures
    Yi Wei Tang
    Department of Medicine, Molecular Infectious Disease Laboratory, Vanderbilt University Hospital, 4605 TVC, Nashville, TN 37232 5310, USA
    J Clin Microbiol 45:1867-73. 2007
    ....
  87. ncbi In-vitro activities of 14-, 15- and 16-membered macrolides against gram-positive cocci
    J M Hamilton-Miller
    Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK
    J Antimicrob Chemother 29:141-7. 1992
    ..These results indicate that it may be difficult to predict the sensitivity of Gram-positive cocci to 16 MM, and therefore individual sensitivity testing to specific compounds is essential...
  88. ncbi Survey of molecular determinants in Gram-positive cocci isolated from hospital settings in Argentina
    Paola E Jeric
    Departamento de Microbiologia, Inmunología y Parasitología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Infect Dev Ctries 1:275-83. 2007
    ..Staphylococcus spp., and Enterococcus spp. isolates collected from 46 hospitals of Argentina over a two-year period...
  89. ncbi A comparison of two airway suctioning frequencies in mechanically ventilated, very-low-birthweight infants
    L Cordero
    Department of Pediatrics, The Ohio State University Medical Center, Columbus, Ohio 43210 1228, USA
    Respir Care 46:783-8. 2001
    ..Routine endotracheal suctioning is inadvisable, but the safe minimum endotracheal suctioning frequency for prevention of airway obstruction has not been determined...
  90. ncbi [Evaluation of the epidemiological, clinical and laboratory findings in continuous ambulatory peritoneal dialysis related peritonitis attacks]
    Cemal Bulut
    S B Ankara Eğitim ve Araştirma Hastanesi, Enfeksiyon Hastaliklan ve Klinik Mikrobiyoloji Klinigi, Ankara
    Mikrobiyol Bul 42:255-64. 2008
    ....
  91. ncbi New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Drugs 70:859-86. 2010
    ....
  92. ncbi The fluoroquinolone antibacterials: past, present and future perspectives
    P C Appelbaum
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Int J Antimicrob Agents 16:5-15. 2000
    ....
  93. pmc Evaluation of the Wider system, a new computer-assisted image-processing device for bacterial identification and susceptibility testing
    R Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid 28034, Spain
    J Clin Microbiol 38:1339-46. 2000
    ..The Wider system is a new reliable tool which applies the image-processing technology to the reading of commercial trays for both bacterial identification and susceptibility testing...
  94. pmc Impact of enhanced infection control at 2 neonatal intensive care units in the Philippines
    Christopher J Gill
    Center for International Health and Development, Department of International Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Clin Infect Dis 48:13-21. 2009
    ..The growing burden of neonatal mortality associated with hospital-acquired neonatal sepsis in the developing world creates an urgent need for cost-effective infection-control measures in resource-limited settings...
  95. ncbi Experience with the use of piperacillin-tazobactam in pediatric non-renal solid organ transplantation
    Silke Wiesmayr
    Department of Pediatrics, Medical University, Innsbruck, Austria
    Pediatr Transplant 11:38-48. 2007
    ..Pip-Tazo may be a suitable single agent for perioperative prophylaxis in pediatric non-renal solid organs recipients, however, a prospective comparative study is needed to make final conclusions...
  96. pmc Clinical validation of the molecular BD GeneOhm StaphSR assay for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in positive blood cultures
    Paul D Stamper
    Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Clin Microbiol 45:2191-6. 2007
    ..The BD GeneOhm StaphSR assay appears to be a valuable diagnostic tool for quickly differentiating bacteremia caused by MSSA and MRSA from that caused by other gram-positive cocci...
  97. ncbi [In vitro antibacterial activity of a new macrolide: miokamycin. Comparison with erythromycin and josamycin]
    C J Soussy
    CHU Henri Mondor, Service de Bacteriologie, Creteil
    Pathol Biol (Paris) 36:370-6. 1988
    ..On Gram positive cocci, mode MIC of E, J, and M for strains sensitive to MLS were respectively (micrograms/ml): Staphylococci: 0...
  98. ncbi Guidelines for interpretation of 16S rRNA gene sequence-based results for identification of medically important aerobic Gram-positive bacteria
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong SAR
    J Med Microbiol 58:1030-6. 2009
    ..To improve the usefulness of the MicroSeq databases, bacterial species that can be confidently identified by 16S rRNA gene sequencing but are not found in the MicroSeq databases should be included...
  99. pmc Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents
    Diane M Citron
    R M Alden Research Laboratory, 2001 Santa Monica Blvd, Suite 685W, Santa Monica CA 90404, USA
    J Clin Microbiol 45:2819-28. 2007
    ..Moderate-to-severe DFIs are typically polymicrobial, and almost half include anaerobes. Our antibiotic susceptibility results can help to inform therapeutic choices...
  100. ncbi Linezolid versus glycopeptide or beta-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Lancet Infect Dis 8:53-66. 2008
    ....
  101. ncbi [Microbiological and clinical studies of vancomycin resistant Leuconostoc spp. and Pediococcus spp. isolated from septicemia patients]
    K Kikuchi
    Department of Medicine, Tokyo Women's Medical College
    Kansenshogaku Zasshi 68:1084-92. 1994
    ..This is the first report in Japan to our knowledge on the identification of Leuconostoc spp. and Pediococcus spp. isolated from human infectious diseases...

Research Grants81

  1. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2010
    ..This project aims to identify and characterize the complex and redundant mechanisms of ?-lactam resistance in an effort to better understand enterococcal physiology and promote identification of novel therapeutic targets. ..
  2. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2011
    ..This project aims to identify and characterize the complex and redundant mechanisms of ?-lactam resistance in an effort to better understand enterococcal physiology and promote identification of novel therapeutic targets. ..
  3. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    Henry Chambers; Fiscal Year: 1999
    ..This will afford a unique and rich opportunity for fellowship and scientific exchange for young and established investigators in the field. ..
  4. ANALYSES OF SITE-SPECIFIC RECOMBINATION
    Jeffrey F Gardner; Fiscal Year: 2010
    ..new insights into the mechanisms of integration and excision of conjugative transposons, which are major contributors to the spread of resistance genes among Bacteroides and other important pathogens such as the gram positive cocci.
  5. Eukaryotic-type signaling mediates two-component regulation of GBS virulence
    Lakshmi Rajagopal; Fiscal Year: 2007
    ..Our findings will also have widespread implications on novel mechanisms of signaling that regulate adaptive responses in other pathogenic and non-pathogenic microbes. ..
  6. Eukaryotic-type signaling mediates two-component regulation of GBS virulence
    Lakshmi Rajagopal; Fiscal Year: 2009
    ..Our findings will also have widespread implications on novel mechanisms of signaling that regulate adaptive responses in other pathogenic and non-pathogenic microbes. ..
  7. Eukaryotic-type signaling mediates two-component regulation of GBS virulence
    Lakshmi Rajagopal; Fiscal Year: 2010
    ..Our findings will also have widespread implications on novel mechanisms of signaling that regulate adaptive responses in other pathogenic and non-pathogenic microbes. ..
  8. Genome Analysis of Streptococcus agalactiae
    Herve Tettelin; Fiscal Year: 2001
    ..This collaborative effort will provide extensive preliminary data for future proposals relevant to understanding the pathogenesis of S. agalactiae infections. ..
  9. Genome Analysis of Streptococcus agalactiae
    Herve Tettelin; Fiscal Year: 2002
    ..This collaborative effort will provide extensive preliminary data for future proposals relevant to understanding the pathogenesis of S. agalactiae infections. ..
  10. VANCOMYCIN RESISTANT GRAM POSITIVE COCCI--G.I. COLONIZATON & DISEASE
    Michael Green; Fiscal Year: 1999
    ..To develop an understanding of the infectious complications of pediatric liver transplantation and to explore the epidemiology and significance of antibiotic resistant bacteria among pediatric liver transplant recipients. ..
  11. Antifungal Resistance Mechanism in Biofilm Growing candida albicans
    David R Andes; Fiscal Year: 2010
    ..The mechanisms underlying the resistance phenotype are poorly understood. The current proposal is designed to determine the role of a secreted carbohydrate in biofilm resistance. ..
  12. Antifungal Resistance Mechanism in Biofilm Growing candida albicans
    David Andes; Fiscal Year: 2009
    ..The mechanisms underlying the resistance phenotype are poorly understood. The current proposal is designed to determine the role of a secreted carbohydrate in biofilm resistance. ..
  13. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  14. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  15. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  16. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  17. Mechanism and Spread of Qnr-Mediated Resistance
    David Hooper; Fiscal Year: 2006
    ....
  18. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2006
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  19. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2005
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  20. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2005
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  21. Pharmacodynamics in Antifungal Resistance
    David Andes; Fiscal Year: 2005
    ..The candidate's goal is to integrate knowledge of antifungal PD and the acquisition of approaches and skills in molecular biology through the completion of this grant. ..
  22. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2005
    ..abstract_text> ..
  23. Molecular Epidemiology, Virulence, and Genomic Characterization of Ureaplasmas
    Ken Waites; Fiscal Year: 2007
    ....
  24. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2007
    ..abstract_text> ..
  25. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    HAROLD MAY; Fiscal Year: 2009
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  26. Plasmid-Mediated Quinolone Resistance
    George A Jacoby; Fiscal Year: 2010
    ....
  27. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2009
    ..abstract_text> ..
  28. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2009
    ..abstract_text> ..
  29. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    HAROLD MAY; Fiscal Year: 2009
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  30. Antifungal Resistance Mechanism in Biofilm Growing candida albicans
    David Andes; Fiscal Year: 2008
    ..The mechanisms underlying the resistance phenotype are poorly understood. The current proposal is designed to determine the role of a secreted carbohydrate in biofilm resistance. ..
  31. Quinolone and multidrug resistance in Staphylococcus aureus
    David Hooper; Fiscal Year: 2008
    ....
  32. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2008
    ..abstract_text> ..
  33. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  34. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  35. TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
    K Nicolaou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2005
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  37. Mechanism and Spread of Qnr-Mediated Resistance
    David Hooper; Fiscal Year: 2005
    ....
  38. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2002
    ..The PI will also determine whether the induction of fibronectin-binding proteins by quinolones in MSSA strains is responsible for the tendency of the MSSA that become quinolone resistant to spread clonally, in contrast to MRSA. ..
  39. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2002
    ..abstract_text> ..
  40. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2001
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  41. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2001
    ..The PI will also determine whether the induction of fibronectin-binding proteins by quinolones in MSSA strains is responsible for the tendency of the MSSA that become quinolone resistant to spread clonally, in contrast to MRSA. ..
  42. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 1999
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  43. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2000
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  44. BACTERIAL QUINOLONE RESISTANCE BY ALTERED DRUG UPTAKE
    David Hooper; Fiscal Year: 1991
    ....
  45. GENETIC ANALYSIS OF GBS ADHERENCE TO FIBRONECTIN
    GLEN TAMURA; Fiscal Year: 2002
    ..These studies will allow for identification of the structural gene(s) for fibronectin adhesin(s). ..
  46. RADIOBIOLOGY OF D RADIODURANS--GENETIC APPROACH
    Michael Daly; Fiscal Year: 1999
    ..These studies will delineate the genetics and biochemistry of radioresistance in D. radiodurans. Insight into its strategies may have broad implications for understanding radioresistance and DSB-metabolism throughout nature. ..
  47. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 1999
    ..The PI will also determine whether the induction of fibronectin-binding proteins by quinolones in MSSA strains is responsible for the tendency of the MSSA that become quinolone resistant to spread clonally, in contrast to MRSA. ..
  48. Microbial Degradation of Petroleum Hydrocarbons and PCBs
    HAROLD MAY; Fiscal Year: 2004
    ..It is predicted that this innovative research will lead to the development of new technologies for the co-bioremediation of PCBs and petroleum. ..
  49. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2004
    ..abstract_text> ..
  50. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  51. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2004
    ..abstract_text> ..
  52. BACTERIAL QUINOLONE RESISTANCE BY ALTERED DRUG UPTAKE
    David Hooper; Fiscal Year: 1990
    ....
  53. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  54. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2003
    ..abstract_text> ..
  56. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2008
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  57. SYNTHESIS OF ANTIBIOTICS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  58. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    Harold D May; Fiscal Year: 2010
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  59. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2008
    ..abstract_text> ..
  60. Synthesis of Marine Neurotoxins
    K C Nicolaou; Fiscal Year: 2010
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  61. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  62. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2009
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  63. RADIOBIOLOGY OF D RADIODURANS--GENETIC APPROACH
    Michael Daly; Fiscal Year: 2000
    ..These studies will delineate the genetics and biochemistry of radioresistance in D. radiodurans. Insight into its strategies may have broad implications for understanding radioresistance and DSB-metabolism throughout nature. ..
  64. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  65. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2003
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  66. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2002
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  67. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2003
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  68. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  69. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2002
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  70. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  71. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    HAROLD MAY; Fiscal Year: 2008
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  72. RADIOBIOLOGY OF D RADIODURANS--GENETIC APPROACH
    Michael Daly; Fiscal Year: 2001
    ..These studies will delineate the genetics and biochemistry of radioresistance in D. radiodurans. Insight into its strategies may have broad implications for understanding radioresistance and DSB-metabolism throughout nature. ..
  73. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2001
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  74. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2004
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..