ehrlichia chaffeensis

Summary

Summary: A species of gram-negative bacteria that is the causative agent of human EHRLICHIOSIS. This organism was first discovered at Fort Chaffee, Arkansas, when blood samples from suspected human ehrlichiosis patients were studied.

Top Publications

  1. ncbi Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    Bing Zhu
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:4243-55. 2009
  2. ncbi Surface-exposed proteins of Ehrlichia chaffeensis
    Yan Ge
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 75:3833-41. 2007
  3. ncbi Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
  4. ncbi Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins
    Vijayakrishna Singu
    Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 73:79-87. 2005
  5. ncbi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
  6. ncbi The developmental cycle of Ehrlichia chaffeensis in vertebrate cells
    Jian Zhi Zhang
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Cell Microbiol 9:610-8. 2007
  7. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
  8. ncbi Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles
    Weichao Bao
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 191:278-86. 2009
  9. ncbi Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: an antigen-expressing gene that exhibits interstrain variation
    J W Sumner
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1447-53. 1999
  10. ncbi Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 17:87-97. 2010

Research Grants

  1. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2004
  2. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
  3. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006
  4. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2002
  5. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2007
  6. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
  7. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2009
  8. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
  9. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 1999
  10. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2001

Detail Information

Publications182 found, 100 shown here

  1. ncbi Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    Bing Zhu
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:4243-55. 2009
    ..Chromatin immunoprecipitation (ChIP) with DNA sequencing revealed an Ehrlichia chaffeensis p200 interaction located within host promoter and intronic Alu-Sx elements, the most abundant repetitive ..
  2. ncbi Surface-exposed proteins of Ehrlichia chaffeensis
    Yan Ge
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 75:3833-41. 2007
    The surface proteins of Ehrlichia chaffeensis provide an important interface for pathogen-host interactions. To investigate the surface proteins of E...
  3. ncbi Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
    ..The genome of Ehrlichia chaffeensis, an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, encodes a single protein ..
  4. ncbi Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins
    Vijayakrishna Singu
    Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 73:79-87. 2005
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, causes human monocyte/macrophage-tropic ehrlichiosis. In this study, proteomic approaches were used to demonstrate host cell-specific antigenic expression by E. chaffeensis...
  5. ncbi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
    ..and Ehrlichia spp. cause several emerging human infectious diseases. Anaplasma phagocytophilum and Ehrlichia chaffeensis are transmitted between mammals by blood-sucking ticks and replicate inside mammalian white blood cells ..
  6. ncbi The developmental cycle of Ehrlichia chaffeensis in vertebrate cells
    Jian Zhi Zhang
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Cell Microbiol 9:610-8. 2007
    b>Ehrlichia chaffeensis, an obligatory intracellular bacterium, has two forms in mammalian cells: small dense-cored cells (DC) with dense nucleoid and larger reticulate cells (RC) with uniformly dispersed nucleoid...
  7. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
    Previous studies of Ehrlichia chaffeensis infection in the mouse have demonstrated that passive transfer of polyclonal Abs from resistant immunocompetent mice to susceptible SCID mice ameliorated infection and disease, even when Abs were ..
  8. ncbi Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles
    Weichao Bao
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 191:278-86. 2009
    ..to several virB genes and virD4 of Agrobacterium tumefaciens are found in an intravacuolar pathogen Ehrlichia chaffeensis, the tick-borne causative agent of human monocytic ehrlichiosis...
  9. ncbi Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: an antigen-expressing gene that exhibits interstrain variation
    J W Sumner
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1447-53. 1999
    A clone expressing an immunoreactive protein with an apparent molecular mass of 44 kDa was selected from an Ehrlichia chaffeensis Arkansas genomic library by probing with anti-E. chaffeensis hyperimmune mouse ascitic fluid...
  10. ncbi Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 17:87-97. 2010
    Recently, major species-specific antibody epitopes in three immunoreactive tandem repeat proteins (TRPs) of Ehrlichia chaffeensis, TRP32, TRP47, and TRP120, have been identified and molecularly characterized within tandem repeat (TR) ..
  11. ncbi The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts
    Ahmet Unver
    Department of Veterinary Biosciences, The Ohio State University, Columbus 43210-1093, USA
    Infect Immun 70:4701-4. 2002
    Sixteen of 22 omp-1 paralogs encoding 28-kDa-range immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocytes of dogs throughout a 56-day infection period. Only one paralog was transcribed by E...
  12. ncbi Antibodies highly effective in SCID mice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization
    Julia Shu-Yi Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 169:1419-25. 2002
    ..been shown previously to protect SCID mice from lethal infection by the obligate intracellular bacterium Ehrlichia chaffeensis, even when administered well after infection has been established...
  13. ncbi Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
    Mingqun Lin
    Department of Veterinary Biosciences. Neurobiotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 70:889-98. 2002
    b>Ehrlichia chaffeensis, a bacterium that cannot survive outside the eukaryotic cell, proliferates exclusively in human monocytes and macrophages...
  14. ncbi Mass spectrometric analysis of Ehrlichia chaffeensis tandem repeat proteins reveals evidence of phosphorylation and absence of glycosylation
    Abdul Wakeel
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e9552. 2010
    b>Ehrlichia chaffeensis has a small subset of immunoreactive secreted, acidic (pI approximately 4), tandem repeat (TR)-containing proteins (TRPs), which exhibit abnormally large electrophoretic masses that have been associated with ..
  15. ncbi Simultaneous detection of Anaplasma marginale and a new Ehrlichia species closely related to Ehrlichia chaffeensis by sequence analyses of 16S ribosomal DNA in Boophilus microplus ticks from Tibet
    Bohai Wen
    Department of Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    J Clin Microbiol 40:3286-90. 2002
    ..The other sequence was most similar to that of the gene of Ehrlichia chaffeensis, an etiological agent of human monocytic ehrlichiosis...
  16. ncbi Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis
    Vijayakrishna Singu
    Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, 66506, USA
    Cell Microbiol 8:1475-87. 2006
    b>Ehrlichia chaffeensis and Ehrlichia canis are tick-transmitted rickettsial pathogens that cause human and canine monocytic ehrlichiosis respectively...
  17. ncbi An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking
    Abdul Wakeel
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:1734-45. 2009
    b>Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes forming cytoplasmic membrane-bound microcolonies called morulae. To survive and replicate within phagocytes, E...
  18. ncbi Total, membrane, and immunogenic proteomes of macrophage- and tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods
    Gwi Moon Seo
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, USA
    Infect Immun 76:4823-32. 2008
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E...
  19. ncbi Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development
    Yumi Kumagai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 190:3597-605. 2008
    b>Ehrlichia chaffeensis, an obligatory intracellular gram-negative bacterium, must take up various nutrients and metabolic compounds because it lacks many genes involved in metabolism...
  20. ncbi Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion
    Yumi Kumagai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210-1093, USA
    Infect Immun 74:5014-22. 2006
    b>Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, replicates in early endosomes by avoiding lysosomal fusion in monocytes and macrophages. In E...
  21. ncbi Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family
    S Wesley Long
    Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 70:1824-31. 2002
    The transcriptional activity and allele variation of the 28-kDa outer membrane protein gene (p28) of Ehrlichia chaffeensis were analyzed to determine the mechanism of the antigenic variation of the 28-kDa outer membrane proteins...
  22. ncbi Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice
    Roman R Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 75:135-45. 2007
    Human monocytic ehrlichiosis is caused by a tick-transmitted rickettsia, Ehrlichia chaffeensis. We recently reported that E. chaffeensis grown in tick cells expresses different proteins than bacteria grown in macrophages...
  23. ncbi Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles
    Jian-zhi Zhang
    Departments of Pathology and Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Infect Immun 72:498-507. 2004
    b>Ehrlichia chaffeensis is an obligatory intracellular bacterium which resides in an early endosome in monocytes. E. chaffeensis infection in a human monocyte cell line (THP1) significantly altered the transcriptional levels of 4...
  24. ncbi Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, 1925 Coffey Road, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 6:175-86. 2004
    ..b>Ehrlichia chaffeensis, an obligatory intramonocytic Gram-negative bacterium, causes human monocytic ehrlichiosis...
  25. ncbi Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
    Jian-zhi Zhang
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA
    Infect Immun 72:4336-43. 2004
    The 28-kDa immunodominant outer membrane proteins (P28 OMPs) of Ehrlichia chaffeensis are encoded by a multigene family. As an indirect measure of the in vivo expression of the members of the p28 multigene family of E...
  26. ncbi Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes
    Roman Reddy Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 70:380-8. 2002
    Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis...
  27. ncbi Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest Missouri
    John G Steiert
    Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
    Vector Borne Zoonotic Dis 2:53-60. 2002
    Both Ehrlichia chaffeensis and Ehrlichia ewingii are causative agents of human ehrlichiosis. Both pathogens are transmitted to humans through the bite of an infected lone star tick (Amblyomma americanum)...
  28. ncbi Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
    b>Ehrlichia chaffeensis is an obligately intracellular, tick-transmitted bacterium that is maintained in nature in a cycle involving at least one and perhaps several vertebrate reservoir hosts. The moderate to severe disease caused by E...
  29. ncbi Tyrosine-phosphorylated Ehrlichia chaffeensis and Ehrlichia canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats
    Jere W McBride
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 79:3178-87. 2011
    A small subset of major immunoreactive proteins have been identified in Ehrlichia chaffeensis and Ehrlichia canis, including three molecularly and immunologically characterized pairs of immunoreactive tandem repeat protein (TRP) ..
  30. ncbi Predominance of Ehrlichia chaffeensis in Rhipicephalus sanguineus ticks from kennel-confined dogs in Limbe, Cameroon
    Lucy M Ndip
    Department of Biochemistry, University of Buea, P O Box 63, Buea, Cameroon
    Exp Appl Acarol 50:163-8. 2010
    ..b>Ehrlichia chaffeensis DNA was detected in 33 (56%) ticks, E...
  31. ncbi Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:1586-94. 2001
    ..course and laboratory evaluation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E...
  32. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
    ..19%) I. pacificus ticks and 5 (8.62%) D. variabilis ticks. Ehrlichia chaffeensis, the causative agent of HME, was detected by nested PCR in just five (0.64%) I...
  33. ncbi Natural history of Ehrlichia chaffeensis: vertebrate hosts and tick vectors from the United States and evidence for endemic transmission in other countries
    Michael J Yabsley
    Department of Population Health, The University of Georgia, Athens, GA 30602, USA
    Vet Parasitol 167:136-48. 2010
    b>Ehrlichia chaffeensis, an intracellular gram-negative zoonotic bacterium, is the causative agent of human monocytotropic ehrlichiosis (HME)...
  34. ncbi Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Curr Opin Microbiol 13:59-66. 2010
    ..b>Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus...
  35. ncbi Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007
    F Scott Dahlgren
    Division of Vectorborne Infectious Diseases, National Center for Enteric, Zoonotic, and Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 85:124-31. 2011
    b>Ehrlichia chaffeensis causes human monocytic ehrlichiosis, and Anaplasma phagocytophilum causes human granulocytic anaplasmosis. These related tick-borne rickettsial organisms can cause severe and fatal illness...
  36. ncbi Variability in the 28-kDa surface antigen protein multigene locus of isolates of the emerging disease agent Ehrlichia chaffeensis suggests that it plays a role in immune evasion
    G R Reddy
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA
    Mol Cell Biol Res Commun 1:167-75. 1999
    ..locus encoding 28 kDa surface antigen proteins (28 kDa SAPs) for two closely related rickettsials, Ehrlichia chaffeensis and Ehrlichia canis (Reddy, G. R., et al. (1998) Biochem. Biophys. Res. Commun...
  37. ncbi Naturally occurring Ehrlichia chaffeensis infection in coyotes from Oklahoma
    A A Kocan
    Oklahoma State University, Stillwater, Oklahoma 74078, USA aak4453
    Emerg Infect Dis 6:477-80. 2000
    A nested polymerase chain reaction assay was used to determine the presence of Ehrlichia chaffeensis, E. canis, and E. ewingii DNA in blood samples of free-ranging coyotes from central and northcentral Oklahoma...
  38. ncbi Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes
    Lalitha Peddireddi
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    BMC Microbiol 9:99. 2009
    b>Ehrlichia chaffeensis is a rickettsial agent responsible for an emerging tick-borne illness, human monocytic ehrlichiosis. Recently, we reported that E...
  39. ncbi L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells
    Jian Zhi Zhang
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, 301 Univ Blvd, Galveston, TX 77555, USA
    FEMS Microbiol Lett 227:303-9. 2003
    b>Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, is an obligatory intracellular bacterium that exhibits monocytic host cell tropism. Ehrlichiae must enter the host cell, and then establish infection. The tropism of E...
  40. ncbi Identification and prevalence of Ehrlichia chaffeensis infection in Haemaphysalis longicornis ticks from Korea by PCR, sequencing and phylogenetic analysis based on 16S rRNA gene
    Seung-Ok Lee
    Bio-Safety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea
    J Vet Sci 6:151-5. 2005
    ..This is the first study to report molecular detection and phylogenetic analysis of E. chaffeensis from H. longicornis ticks in Korea. The implicit significance of E. chaffeensis infection in H. longicornis ticks in Korea is discussed...
  41. ncbi Detection of antibodies to Anaplasma phagocytophilum and Ehrlichia chaffeensis antigens in sera of Korean patients by western immunoblotting and indirect immunofluorescence assays
    Jin-Ho Park
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287, USA
    Clin Diagn Lab Immunol 10:1059-64. 2003
    ..to detect antibodies against Anaplasma phagocytophilum (the human granulocytic ehrlichiosis agent) and Ehrlichia chaffeensis (the human monocytic ehrlichiosis agent) by indirect fluorescent-antibody assay (IFA) and the Western blot ..
  42. ncbi Evaluation of a prototype Ehrlichia chaffeensis surveillance system using white-tailed deer (Odocoileus virginianus) as natural sentinels
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602
    Vector Borne Zoonotic Dis 3:195-207. 2003
    The natural history of Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, includes the lone star tick (LST, Amblyomma americanum) as a vector and white-tailed deer (WTD; Odocoileus virginianus) as both a ..
  43. ncbi Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Cell Microbiol 5:809-20. 2003
    Obligatory intracellular, human ehrlichiosis agents Ehrlichia chaffeensis and Anaplasma phagocytophilum create unique replicative compartments devoid of lysosomal markers in monocytes/macrophages and granulocytes respectively...
  44. ncbi Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae)
    S Wesley Long
    Department of Pathology, WHO Collaborating Center for Tropical Disease, University of Texas Medical Branch, Galveston, TX 77555-0609, USA
    J Med Entomol 40:1000-4. 2003
    It has long been assumed that Ehrlichia chaffeensis (Anderson, Dawson & Wilson), is not transmitted transovarially in the lone star tick vector Amblyomma americanum (L.)...
  45. ncbi Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum are agents of human monocytic and granulocytic ehrlichioses, respectively. They are extremely sensitive to mechanical stress and are pleomorphic gram-negative bacteria...
  46. ncbi Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Vet Parasitol 167:155-66. 2010
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells...
  47. ncbi Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR
    S Branger
    , CNRS UMR 6020A, , Marseille, France
    Antimicrob Agents Chemother 48:4822-8. 2004
    We determined MICs of antibiotics against Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia canis by real-time quantitative PCR. The doubling times of the organisms were established: 19 h for E. chaffeensis, 26 h for A...
  48. ncbi Major species-specific antibody epitopes of the Ehrlichia chaffeensis p120 and E. canis p140 orthologs in surface-exposed tandem repeat regions
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 16:982-90. 2009
    b>Ehrlichia chaffeensis and E. canis have a small subset of tandem repeat (TR)-containing protein orthologs, including p120/p140, which elicit strong antibody responses...
  49. ncbi Identification of a glycosylated Ehrlichia canis 19-kilodalton major immunoreactive protein with a species-specific serine-rich glycopeptide epitope
    Jere W McBride
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Infect Immun 75:74-82. 2007
    ..characterization of this highly conserved 19-kDa major immunoreactive glycoprotein (gp19) ortholog of the Ehrlichia chaffeensis variable-length PCR target (VLPT) protein. E...
  50. ncbi More about human monocytotropic ehrlichiosis in Brazil: serological evidence of nine new cases
    Paulo Sérgio Gonçalves da Costa
    Postgraduate Program in Tropical Medicine, UFMG Medical School, Belo Horizonte, Brazil
    Braz J Infect Dis 10:7-10. 2006
    Human Ehrlichia chaffeensis infections have been reported in North America, Asia and Europe, but only recently have human cases been reported in Brazil. Nine new human cases of E...
  51. ncbi Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein
    Zhihui Cheng
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 190:2096-105. 2008
    ..In the rickettsial pathogen Ehrlichia chaffeensis, the virBD genes are split into two operons, the virB3-virB6 (preceded by sodB) and virB8-virD4 operons...
  52. ncbi A variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in acidic serine-rich tandem repeats
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 76:1572-80. 2008
    b>Ehrlichia chaffeensis and E. canis have a small subset of tandem repeat (TR)-containing proteins that elicit strong host immune responses and are associated with host-pathogen interactions...
  53. ncbi Detection of Ehrlichia chaffeensis in Brazilian marsh deer (Blastocerus dichotomus)
    Rosangela Zacarias Machado
    Universidade Estadual Paulista, Unesp campus de Jaboticabal, Departamento de Patologia Veterinária, FCAV UNESP Rodovia de Acesso Paulo Donato Castellane, s n Jaboticabal, SP, Brazil
    Vet Parasitol 139:262-6. 2006
    b>Ehrlichia chaffeensis was detected for the first time in blood samples from Brazilian marsh deers (Blastocerus dichotomus) captured in the marshes of Parana River in Southeast Brazil in 1998...
  54. ncbi Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats
    C Kuyler Doyle
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Infect Immun 74:711-20. 2006
    ..canis gp36 and E. chaffeensis gp47 were differentially expressed only on the surface of dense-cored ehrlichiae and detected in the Ehrlichia-free supernatants, indicating that these proteins are released extracellularly during infection...
  55. ncbi A real-time combined polymerase chain reaction assay for the rapid detection and differentiation of Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii
    Constance A Bell
    Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diagn Microbiol Infect Dis 53:301-6. 2005
    ..PCR) assay capable of the simultaneous detection and differentiation of Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii was developed using the LightCyclertrade mark instrument (Roche Applied Sciences, ..
  56. ncbi Spatial analysis of the distribution of Ehrlichia chaffeensis, causative agent of human monocytotropic ehrlichiosis, across a multi-state region
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, D B Warnell School of Forest Resources, and Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Am J Trop Med Hyg 72:840-50. 2005
    b>Ehrlichia chaffeensis, which causes human monocytotrophic ehrlichiosis (HME), is an important emerging tick-borne pathogen in the southeastern and southcentral United States. The endemnicity probability of E...
  57. ncbi Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins
    Haibin Huang
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    Infect Immun 76:3405-14. 2008
    b>Ehrlichia chaffeensis is an obligately intracellular gram-negative bacterium and is the etiologic agent of human monocytic ehrlichiosis (HME). Although E...
  58. ncbi Ehrlichia chaffeensis in child, Venezuela
    Maria C Martinez
    Emerg Infect Dis 14:519-20. 2008
  59. ncbi Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 9:861-74. 2007
    b>Ehrlichia chaffeensis is an obligate intracellular bacterium which replicates in monocytes or macrophages, the primary producers of reactive oxygen species (ROS). However, effects of ROS on E. chaffeensis infection and whether E...
  60. ncbi Survival, replication, and antibody susceptibility of Ehrlichia chaffeensis outside of host cells
    Julia Shu-Yi Li
    Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York 12201, USA
    Infect Immun 71:4229-37. 2003
    b>Ehrlichia chaffeensis, an obligate intracellular, tick-transmitted bacterium, is susceptible to antibody-mediated host defense, but the mechanism by which this occurs is not understood...
  61. ncbi [Serologic evidence for human Ehrlichiosis in Chile]
    Javier Lopez
    Clínica Veterinaria Alcántara, Puente Alto, Santiago, Chile
    Rev Med Chil 131:67-70. 2003
    ..Ehrlichiosis is a non contagious infectious disease, mainly transmitted by thick bites. In 1998, this infection was detected in dogs, for the first time, in Chile...
  62. ncbi Antibody-mediated elimination of the obligate intracellular bacterial pathogen Ehrlichia chaffeensis during active infection
    G M Winslow
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    Infect Immun 68:2187-95. 2000
    ..Here, we examined immunity against infection by Ehrlichia chaffeensis, an obligate intracellular bacterium that causes human monocytic ehrlichiosis...
  63. ncbi Identification of Ehrlichia chaffeensis by nested PCR in ticks from Southern China
    W C Cao
    Institute of Microbiology and Epidemiology, Beijing 100071, China
    J Clin Microbiol 38:2778-80. 2000
    A total of 717 ticks collected from southern China were examined by nested PCR for the presence of Ehrlichia chaffeensis. Sixteen (55. 2%) of 29 adult Amblyomma testudinarium ticks and 28 (11.7%) of 240 adult and at least 4...
  64. ncbi Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:2496-502. 1997
    Two new isolates of Ehrlichia chaffeensis (designated Jax and St. Vincent) were obtained from patients with fatal ehrlichial infections. Patients developed characteristic manifestations of severe disease due to E...
  65. ncbi Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome
    Chuanmin Cheng
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 71:187-95. 2003
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, is responsible for human monocytic ehrlichiosis (HME). In this study, we genetically mapped 10 isolates obtained from HME patients...
  66. ncbi Human ehrlichioses
    Juan P Olano
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    Med Clin North Am 86:375-92. 2002
    ....
  67. ncbi Susceptibility of red and gray foxes to infection by Ehrlichia chaffeensis
    W R Davidson
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens 30602, USA
    J Wildl Dis 35:696-702. 1999
    ..foxes (Urocyon cinereoargenteus) were evaluated for their susceptibility to experimental infection with Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis...
  68. ncbi Persistent Ehrlichia chaffeensis infection in white-tailed deer
    W R Davidson
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens 30602, USA
    J Wildl Dis 37:538-46. 2001
    ..deer (Odocoileus virginianus) were inoculated intravenously with a deer-origin isolate (15B-WTD-GA) of Ehrlichia chaffeensis. The course of infection was monitored using indirect fluorescent antibody (IFA), polymerase chain ..
  69. ncbi Identification of Ehrlichia chaffeensis, Anaplasma phagocytophilum, and A. bovis in Haemaphysalis longicornis and Ixodes persulcatus ticks from Korea
    Chul-Min Kim
    Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk, Korea
    Vector Borne Zoonotic Dis 3:17-26. 2003
    ..chaffeensis, A. phagocytophilum, or A. bovis are not known. This study is the first to demonstrate the presence of E. chaffeensis, A. phagocytophilum and A. bovis in Korean ticks...
  70. ncbi Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis
    G M Winslow
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    Infect Immun 66:3892-9. 1998
    ..to human monocytic ehrlichiosis (HME), immunocompetent and immunocompromised mice were infected with Ehrlichia chaffeensis and bacterial loads were measured by PCR and by immunohistochemistry. Immunocompetent (C...
  71. ncbi Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii
    E B Breitschwerdt
    Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Clin Microbiol 36:2645-51. 1998
    ..provided PCR evidence that healthy dogs from southeastern Virginia could be naturally infected with Ehrlichia chaffeensis. This observation stimulated us to determine which Ehrlichia spp...
  72. ncbi Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila
    Robert F Massung
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    DNA Cell Biol 21:587-96. 2002
    The rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila have been analyzed. The 16S rRNA genes were previously characterized for both of these agents...
  73. ncbi Enhanced spatial models for predicting the geographic distributions of tick-borne pathogens
    Michael C Wimberly
    Geographic Information Science Center of Excellence, South Dakota State University, Brookings, SD, USA
    Int J Health Geogr 7:15. 2008
    ..spatial modelling approaches for predicting the geographic distributions of two tick-borne pathogens: Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, and Anaplasma phagocytophilum, the causative ..
  74. ncbi Ehrlichiosis
    Gordon E Schutze
    University of Arkansas for Medical Sciences, College of Medicine, and Arkansas Children's Hospital, Little Rock, AR, USA
    Pediatr Infect Dis J 25:71-2. 2006
  75. ncbi Molecular cloning and characterization of the 120-kilodalton protein gene of Ehrlichia canis and application of the recombinant 120-kilodalton protein for serodiagnosis of canine ehrlichiosis
    X J Yu
    Department of Pathology, WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Clin Microbiol 38:369-74. 2000
    The 120-kDa outer membrane protein (p120) is a potential adhesin of Ehrlichia chaffeensis, and recombinant p120 is very useful for serodiagnosis of human monocytotropic ehrlichiosis...
  76. ncbi Evidence of tick-borne organisms in mule deer (Odocoileus hemionus) from the western United States
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 5:351-62. 2005
    ..Together, these data suggest that MD in northern Arizona and eastern California are exposed to several pathogens of human and veterinary importance...
  77. ncbi Clinical, epidemiologic, and environmental surveillance for ehrlichiosis and anaplasmosis in an endemic area of northern California
    Curtis L Fritz
    Division of Communicable Disease Control, California Department of Health Services, Sacramento, CA 95899-7413, USA
    J Vector Ecol 30:4-10. 2005
    ..have been recognized in California since the mid-1990s: human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum...
  78. ncbi Serological evidence of infection of Anaplasma and Ehrlichia in domestic animals in Xinjiang Uygur Autonomous Region area, China
    Bayin Chahan
    Veterinary College, Xingjiang Agricultural University, Urumqui, China
    Vet Parasitol 134:273-8. 2005
    ..Antibody titers up to 1:320 were recorded. These results indicate that ruminants kept in these areas may be infected with some species of Anaplasma and Ehrlichia...
  79. ncbi Ehrlichia chaffeensis antibodies in white-tailed deer, Iowa, 1994 and 1996
    L Mueller Anneling
    University of Iowa College of Public Health, Iowa City, Iowa 52242 5000, USA
    Emerg Infect Dis 6:397-400. 2000
    Surveillance of 2,277 white-tailed deer for antibodies against Ehrlichia chaffeensis in Iowa showed seropositivity rates of 12.5% in 1994 and 13.9% in 1996...
  80. ncbi Habitat factors influencing distributions of Anaplasma phagocytophilum and Ehrlichia chaffeensis in the Mississippi Alluvial Valley
    J S Manangan
    Warnell School of Forestry and Natural Resources, University of Georgia, College of Veterinary Medicine, Athens, Georgia, USA
    Vector Borne Zoonotic Dis 7:563-73. 2007
    Human monocytotropic ehrlichiosis (HME), caused by the bacterium Ehrlichia chaffeensis, and human granulocytic anaplasmosis (HGA), caused by the bacterium Anaplasma phagocytophilum, are two emerging tick-borne zoonoses of concern...
  81. ncbi [First detection of Ehrlichiosis detected serologically and with the polymerase chain reaction in patients with borreliosis in the Czech Republic]
    D Hulinska
    Oddĕlení prírodních ohniskových nákaz Centra epidemiologie a mikrobiologie Státního zdravotního ústavu, Národní referencní laborator pro borreliózu, Praha
    Cas Lek Cesk 140:181-4. 2001
    ..From 37 goal-directed examinations done in years 1998-2000, bacteria Ehrlichia chaffeensis was found to be the cause of human monocytic ehrlichiosis (HME) in two patients who had stayed in Bulgaria,..
  82. ncbi Ehrlichial proliferation and acute hepatocellular necrosis in immunocompetent mice experimentally infected with the HF strain of Ehrlichia, closely related to Ehrlichia chaffeensis
    H Okada
    Department of Veterinary Pathology, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    J Comp Pathol 124:165-71. 2001
    b>Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, is closely related to the HF strain of Ehrlichia isolated from ticks in Japan...
  83. ncbi Transmission of bacterial agents from lone star ticks to white-tailed deer
    Andrea S Varela-Stokes
    Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    J Med Entomol 44:478-83. 2007
    ..Among these bacteria are the disease agents Ehrlichia chaffeensis and Ehrlichia ewingii, and the putative disease agent "Borrelia lonestari...
  84. ncbi Molecular and serologic evidence of tick-borne Ehrlichiae in three species of lemurs from St. Catherines Island, Georgia, USA
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Zoo Wildl Med 35:503-9. 2004
    ..All 52 adult lemurs were serologically tested for exposure to Ehrlichia chaffeensis and Anaplasma phagocytophilum. Polymerase chain reaction (PCR) assays for E. chaffeensis, A...
  85. ncbi Transmission of Ehrlichia chaffeensis from lone star ticks (Amblyomma americanum) to white-tailed deer (Odocoileus virginianus)
    A S Varela-Stokes
    Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    J Wildl Dis 43:376-81. 2007
    ..Among these is Ehrlichia chaffeensis, which causes human monocytic (or monocytotropic) ehrlichiosis...
  86. ncbi Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents
    A Unver
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1093, USA
    J Clin Microbiol 39:3982-6. 2001
    ..or human granulocytic ehrlichiosis (HGE) may be made on the basis of serologic cross-reactivity between Ehrlichia chaffeensis and the agent of HGE...
  87. ncbi Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel
    Zhihui Cheng
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 8:1241-52. 2006
    ..The present study examined TCS in the obligatory intracellular bacteria Ehrlichia chaffeensis and Anaplasma phagocytophilum, that cause human monocytic ehrlichiosis (HME) and human granulocytic ..
  88. ncbi Co-infection of white-tailed deer with multiple strains of Ehrlichia chaffeensis
    Andrea S Varela-Stokes
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 6:140-51. 2006
    We investigated the effect of exposing deer to multiple strains of Ehrlichia chaffeensis that differed in number of tandem repeats in either the variable-length PCR target (VLPT) gene or 120 kDa antigen gene...
  89. ncbi Human ehrlichiosis: clinical and ecological challenges
    John J Openshaw
    South Med J 100:769-70. 2007
  90. ncbi Budget genome
    Lisa Crossman
    Nat Rev Microbiol 4:326-7. 2006
  91. ncbi Ehrlichiosis: making the diagnosis in the acute setting
    Lisa K Prince
    Infectious Disease Department at Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Washington, DC 20307, USA
    South Med J 100:825-8. 2007
    ..We report a case of HME presenting with negative serologies and positive DNA PCR for Ehrlichia chaffeensis during the acute illness...
  92. ncbi Encephalopathy with seizures having PCR-positive Anaplasma phagocytophilum and Ehrlichia chaffeensis
    N P Young
    Eur J Neurol 14:e3-4. 2007
  93. ncbi Serologic evidence of human granulocytic ehrlichiosis, Greece
    Stella Alexiou Daniel
    Emerg Infect Dis 8:643-4. 2002
  94. ncbi Seroprevalence of human granulocytic ehrlichiosis infection in Belgium
    B Guillaume
    Department of Microbiology, University of Louvain, 54-90 Avenue Hippocrate, 1200 Brussels, Belgium
    Eur J Clin Microbiol Infect Dis 21:397-400. 2002
    ..This is the first report documenting the identification of this agent in Belgium...
  95. ncbi Primary and secondary infection with Ehrlichia chaffeensis in white-tailed deer (Odocoileus virginianus)
    Andrea S Varela
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 5:48-57. 2005
    White-tailed deer (Odocoileus virginianus) are the principal reservoir host for Ehrlichia chaffeensis, causative agent of human monocytic ehrlichiosis (HME). Because white-tailed deer maintain a long-term infection with E...
  96. ncbi Human monocytotropic ehrlichiosis, Missouri
    Juan P Olano
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0747, USA
    Emerg Infect Dis 9:1579-86. 2003
    ..HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME...
  97. ncbi Molecular methods for ehrlichiosis and Lyme disease
    J Stephen Dumler
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Ross Research Building, Room 624, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Clin Lab Med 23:867-84, vi. 2003
    ..This article reviews molecular techniques that have been developed and are effective in the clinical laboratory for the emerging tick-borne infections, ehrlichiosis and Lyme disease...
  98. ncbi [Ehrlichia chaffeensis antibodies prevalence among patients bitten by ticks]
    Maciej Kondrusik
    ,
    Pol Merkur Lekarski 13:462-4. 2002
    ..The purpose of our work was to present 11 cases where antibodies against Ehrlichia chaffeensis were detected in serum...
  99. ncbi [Incidence and seroprevalence of canine ehrlichiosis in the Medjez El Bab region (northwestern Tunisia during 1994, 1995 and 1996]
    A Ghorbel
    , 2020 Sidi Thabet, Tunisie
    Arch Inst Pasteur Tunis 78:41-7. 2001
    ..chaffeensis during the three year studies. The incidence of E. canis infection was 12.6% during the three years whereas E. chaffeensis infection did not exceed 4.7%...
  100. ncbi Divergent interactions of Ehrlichia chaffeensis- and Anaplasma phagocytophilum-infected leukocytes with endothelial cell barriers
    Jinho Park
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Infect Immun 71:6728-33. 2003
    ..Whereas Ehrlichia chaffeensis (HME) often causes meningoencephalitis, this is rare with Anaplasma phagocytophilum infection...
  101. ncbi Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis
    Jacob W IJdo
    Inflammation Program and Department of Internal Medicine, Veterans Administration Medical Center and University of Iowa, Iowa City 52242, USA
    Infect Immun 70:5295-8. 2002
    ..Similarly, the p44 genes were differentially expressed in infected C3H mice, in SCID mice, and in cultured HGE bacteria. Thus, differential p44 expression exists in vivo and in vitro and could provide a basis for antigenic variation...

Research Grants81

  1. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2004
    ..goal of this research project is the elucidation of the mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  2. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
    ..mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.). The project is part of the mentored career development plan for Holly D. Gaff with J...
  3. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006
    ..ehrlichial disease reported in the USA to date, rely on better understanding of interactions between Ehrlichia chaffeensis, the etiologic agent, and its tick host...
  4. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2002
    ..These pathogens include ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E...
  5. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2007
    ..chaffeensis. ..
  6. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  7. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2009
    ..chaffeensis. ..
  8. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
    ..from the Applicant's Abstract): Two tick-borne ehrlichioses, human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) caused by Ehrlichia equi or a closely related organism, have ..
  9. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 1999
    ..to elucidate the interaction of the human patient with the tick-borne, obligately intracellular bacterium Ehrlichia chaffeensis, particularly with the ehrlichial structural and functional components which stimulate protective immunity ..
  10. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2001
    ..The long-term goal of this research is the elucidation of the mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  11. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  12. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  13. EHRLICHIACIDAL MECHANISM BY LEUKOCYTES
    Yasuko Rikihisa; Fiscal Year: 2003
    ..Abstract): Recently, tick-borne diseases caused by infection with two new human ehrlichiosis agents: Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) agent are increasingly recognized in the U.S...
  14. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  15. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2007
    b>Ehrlichia chaffeensis infects monocytes and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...
  16. COMPARISON OF 3 HUMAN EHRLICHIOSIS GENOME SEQUENCES
    Yasuko Rikihisa; Fiscal Year: 2002
    ..States, including a new granulocytotropic ehrlichia, the human granulocytic ehrlichiosis (HGE) agent, and Ehrlichia chaffeensis, a new monocytotropic ehrlichia causes human monocytic ehrlichiosis. E...
  17. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    b>Ehrlichia chaffeensis infects monocytes and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...