ehrlichia chaffeensis

Summary

Summary: A species of gram-negative bacteria that is the causative agent of human EHRLICHIOSIS. This organism was first discovered at Fort Chaffee, Arkansas, when blood samples from suspected human ehrlichiosis patients were studied.

Top Publications

  1. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
  2. pmc Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    Bing Zhu
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:4243-55. 2009
  3. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
  4. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
  5. pmc Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes
    Roman Reddy Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 70:380-8. 2002
  6. pmc Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007
    F Scott Dahlgren
    Division of Vectorborne Infectious Diseases, National Center for Enteric, Zoonotic, and Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 85:124-31. 2011
  7. pmc Surface-exposed proteins of Ehrlichia chaffeensis
    Yan Ge
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 75:3833-41. 2007
  8. doi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
  9. ncbi Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection
    Ann E Sehdev
    Dept of Pathology, Johns Hopkins Medical Institutions, Meyer B1 193, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Clin Pathol 119:859-65. 2003
  10. ncbi Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest Missouri
    John G Steiert
    Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
    Vector Borne Zoonotic Dis 2:53-60. 2002

Research Grants

  1. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
  2. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006
  3. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2004
  4. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2002
  5. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2007
  6. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
  7. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2009
  8. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
  9. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 1999
  10. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2001

Detail Information

Publications199 found, 100 shown here

  1. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum are agents of human monocytic and granulocytic ehrlichioses, respectively. They are extremely sensitive to mechanical stress and are pleomorphic gram-negative bacteria...
  2. pmc Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    Bing Zhu
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:4243-55. 2009
    ..Chromatin immunoprecipitation (ChIP) with DNA sequencing revealed an Ehrlichia chaffeensis p200 interaction located within host promoter and intronic Alu-Sx elements, the most abundant repetitive ..
  3. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
    ..19%) I. pacificus ticks and 5 (8.62%) D. variabilis ticks. Ehrlichia chaffeensis, the causative agent of HME, was detected by nested PCR in just five (0.64%) I...
  4. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
    b>Ehrlichia chaffeensis is an obligately intracellular, tick-transmitted bacterium that is maintained in nature in a cycle involving at least one and perhaps several vertebrate reservoir hosts. The moderate to severe disease caused by E...
  5. pmc Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes
    Roman Reddy Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 70:380-8. 2002
    Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis...
  6. pmc Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007
    F Scott Dahlgren
    Division of Vectorborne Infectious Diseases, National Center for Enteric, Zoonotic, and Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 85:124-31. 2011
    b>Ehrlichia chaffeensis causes human monocytic ehrlichiosis, and Anaplasma phagocytophilum causes human granulocytic anaplasmosis. These related tick-borne rickettsial organisms can cause severe and fatal illness...
  7. pmc Surface-exposed proteins of Ehrlichia chaffeensis
    Yan Ge
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 75:3833-41. 2007
    The surface proteins of Ehrlichia chaffeensis provide an important interface for pathogen-host interactions. To investigate the surface proteins of E...
  8. doi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
    ..and Ehrlichia spp. cause several emerging human infectious diseases. Anaplasma phagocytophilum and Ehrlichia chaffeensis are transmitted between mammals by blood-sucking ticks and replicate inside mammalian white blood cells ..
  9. ncbi Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection
    Ann E Sehdev
    Dept of Pathology, Johns Hopkins Medical Institutions, Meyer B1 193, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Clin Pathol 119:859-65. 2003
    b>Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME) that usually includes fever, myalgias, and pancytopenia and, in 80% to 90% of patients, elevations in serum transaminase levels...
  10. ncbi Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest Missouri
    John G Steiert
    Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
    Vector Borne Zoonotic Dis 2:53-60. 2002
    Both Ehrlichia chaffeensis and Ehrlichia ewingii are causative agents of human ehrlichiosis. Both pathogens are transmitted to humans through the bite of an infected lone star tick (Amblyomma americanum)...
  11. pmc Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Curr Opin Microbiol 13:59-66. 2010
    ..b>Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus...
  12. pmc Transmission electron microscopy reveals distinct macrophage- and tick cell-specific morphological stages of Ehrlichia chaffeensis
    Sarah E Dedonder
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 7:e36749. 2012
    b>Ehrlichia chaffeensis is an emerging tick-borne rickettsial pathogen responsible for human monocytic ehrlichiosis...
  13. pmc Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: an antigen-expressing gene that exhibits interstrain variation
    J W Sumner
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1447-53. 1999
    A clone expressing an immunoreactive protein with an apparent molecular mass of 44 kDa was selected from an Ehrlichia chaffeensis Arkansas genomic library by probing with anti-E. chaffeensis hyperimmune mouse ascitic fluid...
  14. pmc Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles
    Weichao Bao
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 191:278-86. 2009
    ..to several virB genes and virD4 of Agrobacterium tumefaciens are found in an intravacuolar pathogen Ehrlichia chaffeensis, the tick-borne causative agent of human monocytic ehrlichiosis...
  15. ncbi Antibodies highly effective in SCID mice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization
    Julia Shu Yi Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 169:1419-25. 2002
    ..been shown previously to protect SCID mice from lethal infection by the obligate intracellular bacterium Ehrlichia chaffeensis, even when administered well after infection has been established...
  16. pmc Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
    Mingqun Lin
    Department of Veterinary Biosciences Neurobiotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 70:889-98. 2002
    b>Ehrlichia chaffeensis, a bacterium that cannot survive outside the eukaryotic cell, proliferates exclusively in human monocytes and macrophages...
  17. pmc Mass spectrometric analysis of Ehrlichia chaffeensis tandem repeat proteins reveals evidence of phosphorylation and absence of glycosylation
    Abdul Wakeel
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e9552. 2010
    b>Ehrlichia chaffeensis has a small subset of immunoreactive secreted, acidic (pI approximately 4), tandem repeat (TR)-containing proteins (TRPs), which exhibit abnormally large electrophoretic masses that have been associated with ..
  18. pmc Survival, replication, and antibody susceptibility of Ehrlichia chaffeensis outside of host cells
    Julia Shu Yi Li
    Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York 12201, USA
    Infect Immun 71:4229-37. 2003
    b>Ehrlichia chaffeensis, an obligate intracellular, tick-transmitted bacterium, is susceptible to antibody-mediated host defense, but the mechanism by which this occurs is not understood...
  19. ncbi The developmental cycle of Ehrlichia chaffeensis in vertebrate cells
    Jian Zhi Zhang
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Cell Microbiol 9:610-8. 2007
    b>Ehrlichia chaffeensis, an obligatory intracellular bacterium, has two forms in mammalian cells: small dense-cored cells (DC) with dense nucleoid and larger reticulate cells (RC) with uniformly dispersed nucleoid...
  20. ncbi Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis
    Vijayakrishna Singu
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, 66506, USA
    Cell Microbiol 8:1475-87. 2006
    b>Ehrlichia chaffeensis and Ehrlichia canis are tick-transmitted rickettsial pathogens that cause human and canine monocytic ehrlichiosis respectively...
  21. pmc An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking
    Abdul Wakeel
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 77:1734-45. 2009
    b>Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes forming cytoplasmic membrane-bound microcolonies called morulae. To survive and replicate within phagocytes, E...
  22. pmc Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development
    Yumi Kumagai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 190:3597-605. 2008
    b>Ehrlichia chaffeensis, an obligatory intracellular gram-negative bacterium, must take up various nutrients and metabolic compounds because it lacks many genes involved in metabolism...
  23. ncbi Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, 1925 Coffey Road, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 6:175-86. 2004
    ..b>Ehrlichia chaffeensis, an obligatory intramonocytic Gram-negative bacterium, causes human monocytic ehrlichiosis...
  24. pmc Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family
    S Wesley Long
    Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 70:1824-31. 2002
    The transcriptional activity and allele variation of the 28-kDa outer membrane protein gene (p28) of Ehrlichia chaffeensis were analyzed to determine the mechanism of the antigenic variation of the 28-kDa outer membrane proteins...
  25. pmc Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion
    Yumi Kumagai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    Infect Immun 74:5014-22. 2006
    b>Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, replicates in early endosomes by avoiding lysosomal fusion in monocytes and macrophages. In E...
  26. pmc Use of Drosophila S2 cells as a model for studying Ehrlichia chaffeensis infections
    Alison Luce-Fedrow
    Kansas State University, Division of Biology, Manhattan, KS 66506, USA
    Appl Environ Microbiol 74:1886-91. 2008
    b>Ehrlichia chaffeensis is an obligate intracellular bacterium and the causative agent of human monocytic ehrlichiosis...
  27. doi Laboratory maintenance of Ehrlichia chaffeensis and Ehrlichia canis and recovery of organisms for molecular biology and proteomics studies
    Chuanmin Cheng
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
    Curr Protoc Microbiol . 2008
    ..include the human monocytic ehrlichiosis caused by the Amblyomma americanum tick-transmitted bacterium, Ehrlichia chaffeensis; human ewingii ehrlichiosis caused by Ehrlichia ewingii (also transmitted by A...
  28. pmc Penicillin-binding protein of Ehrlichia chaffeensis: cytokine induction through MyD88-dependent pathway
    Mohd Akhlakur Rahman
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1093, USA
    J Infect Dis 206:110-6. 2012
    Human monocytic ehrlichiosis is one of the most prevalent tick-borne zoonoses caused by infection with Ehrlichia chaffeensis. Although E...
  29. pmc Insights into the CtrA regulon in development of stress resistance in obligatory intracellular pathogen Ehrlichia chaffeensis
    Zhihui Cheng
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Microbiol 82:1217-34. 2011
    b>Ehrlichia chaffeensis is an obligate intracellular bacterium that causes human monocytic ehrlichiosis. Ehrlichiae have a biphasic developmental cycle consisting of dense-cored cells (DCs) and reticulate cells (RCs)...
  30. ncbi Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: clinical and molecular characteristics
    S M Standaert
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, and VA Medical Center, Nashville, TN 37232 2637, USA
    J Infect Dis 181:1082-8. 2000
    b>Ehrlichia chaffeensis was sought among patients with a history of tick exposure and fever, and the accuracy of other diagnostic tests was compared with that of primary isolation. Among the 38 patients enrolled, E...
  31. doi Type IV secretion system of Anaplasma phagocytophilum and Ehrlichia chaffeensis
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1166:106-11. 2009
    The intracellular bacterial pathogens Ehrlichia chaffeensis and Anaplasma phagocytophilum have evolved to infect leukocytes and hijack biological compounds and processes of these host defensive cells...
  32. ncbi Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila
    Robert F Massung
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    DNA Cell Biol 21:587-96. 2002
    The rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila have been analyzed. The 16S rRNA genes were previously characterized for both of these agents...
  33. pmc Sensitive detection of Ehrlichia chaffeensis in cell culture, blood, and tick specimens by reverse transcription-PCR
    S Felek
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1093, USA
    J Clin Microbiol 39:460-3. 2001
    b>Ehrlichia chaffeensis is an obligatory intracellular bacterium of monocytes and macrophages and the etiologic agent of human monocytic ehrlichiosis, an emerging zoonosis...
  34. pmc Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report
    D J Sexton
    Duke University Medical Center, Durham, NC 27710, USA
    Emerg Infect Dis 4:311-6. 1998
    ..to be endemic in North Carolina; cases of human ehrlichial infection were recognized there soon after Ehrlichia chaffeensis was recognized as an important cause of tick-borne disease in the southeastern United States...
  35. pmc Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis
    G M Winslow
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    Infect Immun 66:3892-9. 1998
    ..to human monocytic ehrlichiosis (HME), immunocompetent and immunocompromised mice were infected with Ehrlichia chaffeensis and bacterial loads were measured by PCR and by immunohistochemistry. Immunocompetent (C...
  36. pmc Ehrlichia chaffeensis infection of sika deer, Japan
    Makoto Kawahara
    Nagoya City Public Health Research Institute, Nagoya, Japan
    Emerg Infect Dis 15:1991-3. 2009
    To determine whether Ehrlichia chaffeensis exists in Japan, we used PCR to examine blood from sika deer in Nara, Japan. Of 117 deer, 36 (31%) were infected with E. chaffeensis. The E...
  37. pmc Predominance of Ehrlichia chaffeensis in Rhipicephalus sanguineus ticks from kennel-confined dogs in Limbe, Cameroon
    Lucy M Ndip
    Department of Biochemistry, University of Buea, P O Box 63, Buea, Cameroon
    Exp Appl Acarol 50:163-8. 2010
    ..b>Ehrlichia chaffeensis DNA was detected in 33 (56%) ticks, E...
  38. doi Natural history of Ehrlichia chaffeensis: vertebrate hosts and tick vectors from the United States and evidence for endemic transmission in other countries
    Michael J Yabsley
    Department of Population Health, The University of Georgia, Athens, GA 30602, USA
    Vet Parasitol 167:136-48. 2010
    b>Ehrlichia chaffeensis, an intracellular gram-negative zoonotic bacterium, is the causative agent of human monocytotropic ehrlichiosis (HME)...
  39. ncbi Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:1586-94. 2001
    ..course and laboratory evaluation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E...
  40. ncbi L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells
    Jian Zhi Zhang
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, 301 Univ Blvd, Galveston, TX 77555, USA
    FEMS Microbiol Lett 227:303-9. 2003
    b>Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, is an obligatory intracellular bacterium that exhibits monocytic host cell tropism. Ehrlichiae must enter the host cell, and then establish infection. The tropism of E...
  41. pmc Naturally occurring Ehrlichia chaffeensis infection in coyotes from Oklahoma
    A A Kocan
    Oklahoma State University, Stillwater, Oklahoma 74078, USA aak4453
    Emerg Infect Dis 6:477-80. 2000
    A nested polymerase chain reaction assay was used to determine the presence of Ehrlichia chaffeensis, E. canis, and E. ewingii DNA in blood samples of free-ranging coyotes from central and northcentral Oklahoma...
  42. pmc Simultaneous detection of Anaplasma marginale and a new Ehrlichia species closely related to Ehrlichia chaffeensis by sequence analyses of 16S ribosomal DNA in Boophilus microplus ticks from Tibet
    Bohai Wen
    Department of Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    J Clin Microbiol 40:3286-90. 2002
    ..The other sequence was most similar to that of the gene of Ehrlichia chaffeensis, an etiological agent of human monocytic ehrlichiosis...
  43. pmc Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1093, USA
    Infect Immun 69:2083-91. 2001
    ....
  44. pmc Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 66:132-9. 1998
    ..immunodominant major proteins ranging from 23 to 30 kDa were identified in the outer membrane fractions of Ehrlichia chaffeensis and Ehrlichia canis. The N-terminal amino acid sequence of a 28-kDa protein of E...
  45. pmc New insights into molecular Ehrlichia chaffeensis-host interactions
    Abdul Wakeel
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Microbes Infect 12:337-45. 2010
    b>Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by reprogramming the host cell...
  46. ncbi Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel
    Zhihui Cheng
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 8:1241-52. 2006
    ..The present study examined TCS in the obligatory intracellular bacteria Ehrlichia chaffeensis and Anaplasma phagocytophilum, that cause human monocytic ehrlichiosis (HME) and human granulocytic ..
  47. pmc Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii
    E B Breitschwerdt
    Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Clin Microbiol 36:2645-51. 1998
    ..provided PCR evidence that healthy dogs from southeastern Virginia could be naturally infected with Ehrlichia chaffeensis. This observation stimulated us to determine which Ehrlichia spp...
  48. ncbi Ehrlichiae and ehrlichial diseases in china
    Bohai Wen
    Department of Microbiology, Beijing Institute of Microbiology and Epidemiology, PR China
    Ann N Y Acad Sci 990:45-53. 2003
    ..These results reveal that a variety of tick-borne ehrlichial agents and diseases exist in China, and the ehrlichial agents and their tick-vectors are same as or different from that in other countries at species or strain levels...
  49. pmc Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
    ..The genome of Ehrlichia chaffeensis, an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, encodes a single protein ..
  50. pmc Tyrosine-phosphorylated Ehrlichia chaffeensis and Ehrlichia canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats
    Jere W McBride
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 79:3178-87. 2011
    A small subset of major immunoreactive proteins have been identified in Ehrlichia chaffeensis and Ehrlichia canis, including three molecularly and immunologically characterized pairs of immunoreactive tandem repeat protein (TRP) ..
  51. pmc Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins
    Vijayakrishna Singu
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 73:79-87. 2005
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, causes human monocyte/macrophage-tropic ehrlichiosis. In this study, proteomic approaches were used to demonstrate host cell-specific antigenic expression by E. chaffeensis...
  52. pmc Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
    Jian Zhi Zhang
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 72:4336-43. 2004
    The 28-kDa immunodominant outer membrane proteins (P28 OMPs) of Ehrlichia chaffeensis are encoded by a multigene family. As an indirect measure of the in vivo expression of the members of the p28 multigene family of E...
  53. pmc Cyclic dimeric GMP signaling regulates intracellular aggregation, sessility, and growth of Ehrlichia chaffeensis
    Yumi Kumagai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1093, USA
    Infect Immun 79:3905-12. 2011
    ..Replication of an obligatory intracellular pathogen, Ehrlichia chaffeensis, is characterized by formation of bacterial aggregates called morulae inside membrane-bound inclusions...
  54. pmc Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles
    Jian Zhi Zhang
    Departments of Pathology and Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Infect Immun 72:498-507. 2004
    b>Ehrlichia chaffeensis is an obligatory intracellular bacterium which resides in an early endosome in monocytes. E. chaffeensis infection in a human monocyte cell line (THP1) significantly altered the transcriptional levels of 4...
  55. pmc Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 79:4382-91. 2011
    b>Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by evading host cell defense mechanisms. Recently, molecular interactions between E...
  56. ncbi Variability in the 28-kDa surface antigen protein multigene locus of isolates of the emerging disease agent Ehrlichia chaffeensis suggests that it plays a role in immune evasion
    G R Reddy
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA
    Mol Cell Biol Res Commun 1:167-75. 1999
    ..locus encoding 28 kDa surface antigen proteins (28 kDa SAPs) for two closely related rickettsials, Ehrlichia chaffeensis and Ehrlichia canis (Reddy, G. R., et al. (1998) Biochem. Biophys. Res. Commun...
  57. pmc Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice
    Roman R Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 75:135-45. 2007
    Human monocytic ehrlichiosis is caused by a tick-transmitted rickettsia, Ehrlichia chaffeensis. We recently reported that E. chaffeensis grown in tick cells expresses different proteins than bacteria grown in macrophages...
  58. pmc Ehrlichia chaffeensis: a prevalent, life-threatening, emerging pathogen
    David H Walker
    Department of Pathology, University of Texas Medical Branch, World Health OrganizationCollaborating Center for Tropical Diseases, UTMB Center for Biodefense and EmergingInfectious Diseases, Galveston, Texas 77555 0609
    Trans Am Clin Climatol Assoc 115:375-82; discussion 382-4. 2004
    b>Ehrlichia chaffeensis are small, obligately intracellular, endosomal bacteria with tropism for macrophages. Persistent infection in reservoir white-tailed deer is transmitted by lone star ticks...
  59. pmc Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes
    Lalitha Peddireddi
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    BMC Microbiol 9:99. 2009
    b>Ehrlichia chaffeensis is a rickettsial agent responsible for an emerging tick-borne illness, human monocytic ehrlichiosis. Recently, we reported that E...
  60. pmc The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts
    Ahmet Unver
    Department of Veterinary Biosciences, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 70:4701-4. 2002
    Sixteen of 22 omp-1 paralogs encoding 28-kDa-range immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocytes of dogs throughout a 56-day infection period. Only one paralog was transcribed by E...
  61. pmc Total, membrane, and immunogenic proteomes of macrophage- and tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods
    Gwi Moon Seo
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, USA
    Infect Immun 76:4823-32. 2008
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E...
  62. pmc Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 17:87-97. 2010
    Recently, major species-specific antibody epitopes in three immunoreactive tandem repeat proteins (TRPs) of Ehrlichia chaffeensis, TRP32, TRP47, and TRP120, have been identified and molecularly characterized within tandem repeat (TR) ..
  63. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
    Previous studies of Ehrlichia chaffeensis infection in the mouse have demonstrated that passive transfer of polyclonal Abs from resistant immunocompetent mice to susceptible SCID mice ameliorated infection and disease, even when Abs were ..
  64. ncbi Identification and prevalence of Ehrlichia chaffeensis infection in Haemaphysalis longicornis ticks from Korea by PCR, sequencing and phylogenetic analysis based on 16S rRNA gene
    Seung Ok Lee
    Bio Safety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea
    J Vet Sci 6:151-5. 2005
    ..This is the first study to report molecular detection and phylogenetic analysis of E. chaffeensis from H. longicornis ticks in Korea. The implicit significance of E. chaffeensis infection in H. longicornis ticks in Korea is discussed...
  65. ncbi Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae)
    S Wesley Long
    Department of Pathology, WHO Collaborating Center for Tropical Disease, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Med Entomol 40:1000-4. 2003
    It has long been assumed that Ehrlichia chaffeensis (Anderson, Dawson & Wilson), is not transmitted transovarially in the lone star tick vector Amblyomma americanum (L.)...
  66. pmc A variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in acidic serine-rich tandem repeats
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Immun 76:1572-80. 2008
    b>Ehrlichia chaffeensis and E. canis have a small subset of tandem repeat (TR)-containing proteins that elicit strong host immune responses and are associated with host-pathogen interactions...
  67. pmc Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein
    Zhihui Cheng
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 190:2096-105. 2008
    ..In the rickettsial pathogen Ehrlichia chaffeensis, the virBD genes are split into two operons, the virB3-virB6 (preceded by sodB) and virB8-virD4 operons...
  68. pmc Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR
    S Branger
    Unite des Rickettsies, CNRS UMR 6020A, Faculte de Medecine, Marseille, France
    Antimicrob Agents Chemother 48:4822-8. 2004
    We determined MICs of antibiotics against Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia canis by real-time quantitative PCR. The doubling times of the organisms were established: 19 h for E. chaffeensis, 26 h for A...
  69. pmc Ehrlichia chaffeensis in child, Venezuela
    Maria C Martinez
    Emerg Infect Dis 14:519-20. 2008
  70. pmc Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins
    Haibin Huang
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    Infect Immun 76:3405-14. 2008
    b>Ehrlichia chaffeensis is an obligately intracellular gram-negative bacterium and is the etiologic agent of human monocytic ehrlichiosis (HME). Although E...
  71. pmc Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Vet Parasitol 167:155-66. 2010
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells...
  72. ncbi Spatial analysis of the distribution of Ehrlichia chaffeensis, causative agent of human monocytotropic ehrlichiosis, across a multi-state region
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, D B Warnell School of Forest Resources, and Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Am J Trop Med Hyg 72:840-50. 2005
    b>Ehrlichia chaffeensis, which causes human monocytotrophic ehrlichiosis (HME), is an important emerging tick-borne pathogen in the southeastern and southcentral United States. The endemnicity probability of E...
  73. pmc Major species-specific antibody epitopes of the Ehrlichia chaffeensis p120 and E. canis p140 orthologs in surface-exposed tandem repeat regions
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 16:982-90. 2009
    b>Ehrlichia chaffeensis and E. canis have a small subset of tandem repeat (TR)-containing protein orthologs, including p120/p140, which elicit strong antibody responses...
  74. ncbi A real-time combined polymerase chain reaction assay for the rapid detection and differentiation of Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii
    Constance A Bell
    Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diagn Microbiol Infect Dis 53:301-6. 2005
    ..PCR) assay capable of the simultaneous detection and differentiation of Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii was developed using the LightCyclertrade mark instrument (Roche Applied Sciences, ..
  75. pmc Identification of a glycosylated Ehrlichia canis 19-kilodalton major immunoreactive protein with a species-specific serine-rich glycopeptide epitope
    Jere W McBride
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Infect Immun 75:74-82. 2007
    ..characterization of this highly conserved 19-kDa major immunoreactive glycoprotein (gp19) ortholog of the Ehrlichia chaffeensis variable-length PCR target (VLPT) protein. E...
  76. pmc Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats
    C Kuyler Doyle
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Infect Immun 74:711-20. 2006
    ..canis gp36 and E. chaffeensis gp47 were differentially expressed only on the surface of dense-cored ehrlichiae and detected in the Ehrlichia-free supernatants, indicating that these proteins are released extracellularly during infection...
  77. ncbi Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 9:861-74. 2007
    b>Ehrlichia chaffeensis is an obligate intracellular bacterium which replicates in monocytes or macrophages, the primary producers of reactive oxygen species (ROS). However, effects of ROS on E. chaffeensis infection and whether E...
  78. ncbi Detection of Ehrlichia chaffeensis in Brazilian marsh deer (Blastocerus dichotomus)
    Rosangela Zacarias Machado
    Universidade Estadual Paulista, Unesp campus de Jaboticabal, Departamento de Patologia Veterinária, FCAV UNESP Rodovia de Acesso Paulo Donato Castellane, s n Jaboticabal, SP, Brazil
    Vet Parasitol 139:262-6. 2006
    b>Ehrlichia chaffeensis was detected for the first time in blood samples from Brazilian marsh deers (Blastocerus dichotomus) captured in the marshes of Parana River in Southeast Brazil in 1998...
  79. ncbi More about human monocytotropic ehrlichiosis in Brazil: serological evidence of nine new cases
    Paulo Sérgio Gonçalves da Costa
    Postgraduate Program in Tropical Medicine, UFMG Medical School, Belo Horizonte, Brazil
    Braz J Infect Dis 10:7-10. 2006
    Human Ehrlichia chaffeensis infections have been reported in North America, Asia and Europe, but only recently have human cases been reported in Brazil. Nine new human cases of E...
  80. ncbi Evaluation of a prototype Ehrlichia chaffeensis surveillance system using white-tailed deer (Odocoileus virginianus) as natural sentinels
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602
    Vector Borne Zoonotic Dis 3:195-207. 2003
    The natural history of Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, includes the lone star tick (LST, Amblyomma americanum) as a vector and white-tailed deer (WTD; Odocoileus virginianus) as both a ..
  81. ncbi Susceptibility of red and gray foxes to infection by Ehrlichia chaffeensis
    W R Davidson
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens 30602, USA
    J Wildl Dis 35:696-702. 1999
    ..foxes (Urocyon cinereoargenteus) were evaluated for their susceptibility to experimental infection with Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis...
  82. ncbi Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Cell Microbiol 5:809-20. 2003
    Obligatory intracellular, human ehrlichiosis agents Ehrlichia chaffeensis and Anaplasma phagocytophilum create unique replicative compartments devoid of lysosomal markers in monocytes/macrophages and granulocytes respectively...
  83. pmc Detection of antibodies to Anaplasma phagocytophilum and Ehrlichia chaffeensis antigens in sera of Korean patients by western immunoblotting and indirect immunofluorescence assays
    Jin Ho Park
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287, USA
    Clin Diagn Lab Immunol 10:1059-64. 2003
    ..to detect antibodies against Anaplasma phagocytophilum (the human granulocytic ehrlichiosis agent) and Ehrlichia chaffeensis (the human monocytic ehrlichiosis agent) by indirect fluorescent-antibody assay (IFA) and the Western blot ..
  84. pmc Antibody-mediated elimination of the obligate intracellular bacterial pathogen Ehrlichia chaffeensis during active infection
    G M Winslow
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 2002, USA
    Infect Immun 68:2187-95. 2000
    ..Here, we examined immunity against infection by Ehrlichia chaffeensis, an obligate intracellular bacterium that causes human monocytic ehrlichiosis...
  85. pmc Identification of Ehrlichia chaffeensis by nested PCR in ticks from Southern China
    W C Cao
    Institute of Microbiology and Epidemiology, Beijing 100071, China
    J Clin Microbiol 38:2778-80. 2000
    A total of 717 ticks collected from southern China were examined by nested PCR for the presence of Ehrlichia chaffeensis. Sixteen (55. 2%) of 29 adult Amblyomma testudinarium ticks and 28 (11.7%) of 240 adult and at least 4...
  86. ncbi Persistent Ehrlichia chaffeensis infection in white-tailed deer
    W R Davidson
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, The University of Georgia, Athens 30602, USA
    J Wildl Dis 37:538-46. 2001
    ..deer (Odocoileus virginianus) were inoculated intravenously with a deer-origin isolate (15B-WTD-GA) of Ehrlichia chaffeensis. The course of infection was monitored using indirect fluorescent antibody (IFA), polymerase chain ..
  87. pmc Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome
    Chuanmin Cheng
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 71:187-95. 2003
    b>Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, is responsible for human monocytic ehrlichiosis (HME). In this study, we genetically mapped 10 isolates obtained from HME patients...
  88. ncbi [Serologic evidence for human Ehrlichiosis in Chile]
    Javier Lopez
    Clínica Veterinaria Alcántara, Puente Alto, Santiago, Chile
    Rev Med Chil 131:67-70. 2003
    ..Ehrlichiosis is a non contagious infectious disease, mainly transmitted by thick bites. In 1998, this infection was detected in dogs, for the first time, in Chile...
  89. ncbi Human ehrlichioses
    Juan P Olano
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    Med Clin North Am 86:375-92. 2002
    ....
  90. pmc Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:2496-502. 1997
    Two new isolates of Ehrlichia chaffeensis (designated Jax and St. Vincent) were obtained from patients with fatal ehrlichial infections. Patients developed characteristic manifestations of severe disease due to E...
  91. ncbi Identification of Ehrlichia chaffeensis, Anaplasma phagocytophilum, and A. bovis in Haemaphysalis longicornis and Ixodes persulcatus ticks from Korea
    Chul Min Kim
    Bio Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk, Korea
    Vector Borne Zoonotic Dis 3:17-26. 2003
    ..chaffeensis, A. phagocytophilum, or A. bovis are not known. This study is the first to demonstrate the presence of E. chaffeensis, A. phagocytophilum and A. bovis in Korean ticks...
  92. ncbi Co-infection of white-tailed deer with multiple strains of Ehrlichia chaffeensis
    Andrea S Varela-Stokes
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 6:140-51. 2006
    We investigated the effect of exposing deer to multiple strains of Ehrlichia chaffeensis that differed in number of tandem repeats in either the variable-length PCR target (VLPT) gene or 120 kDa antigen gene...
  93. ncbi Encephalopathy with seizures having PCR-positive Anaplasma phagocytophilum and Ehrlichia chaffeensis
    N P Young
    Eur J Neurol 14:e3-4. 2007
  94. pmc Major antigenic proteins of the agent of human granulocytic ehrlichiosis are encoded by members of a multigene family
    C I Murphy
    Aquila Biopharmaceuticals, Inc, Worcester, Massachusetts 01605, USA
    Infect Immun 66:3711-8. 1998
    ..These data suggest that the 43- and 45-kDa proteins of the HGE agent are encoded by members of the GE MSP-2 multigene family...
  95. ncbi Habitat factors influencing distributions of Anaplasma phagocytophilum and Ehrlichia chaffeensis in the Mississippi Alluvial Valley
    J S Manangan
    Warnell School of Forestry and Natural Resources, University of Georgia, College of Veterinary Medicine, Athens, Georgia, USA
    Vector Borne Zoonotic Dis 7:563-73. 2007
    Human monocytotropic ehrlichiosis (HME), caused by the bacterium Ehrlichia chaffeensis, and human granulocytic anaplasmosis (HGA), caused by the bacterium Anaplasma phagocytophilum, are two emerging tick-borne zoonoses of concern...
  96. pmc Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis
    Jacob W IJdo
    Inflammation Program and Department of Internal Medicine, Veterans Administration Medical Center and University of Iowa, Iowa City 52242, USA
    Infect Immun 70:5295-8. 2002
    ..Similarly, the p44 genes were differentially expressed in infected C3H mice, in SCID mice, and in cultured HGE bacteria. Thus, differential p44 expression exists in vivo and in vitro and could provide a basis for antigenic variation...
  97. ncbi [Ehrlichia chaffeensis antibodies prevalence among patients bitten by ticks]
    Maciej Kondrusik
    Klinika Chorób Zakaźnych i Neuroinfekcji AM, Białymstoku
    Pol Merkur Lekarski 13:462-4. 2002
    ..The purpose of our work was to present 11 cases where antibodies against Ehrlichia chaffeensis were detected in serum...
  98. pmc Serologic and molecular detection of Ehrlichia chaffeensis and Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) in Korean patients
    Eun Jeong Heo
    Department of Veterinary Internal Medicine and Clinical Pathology, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561 756, Korea
    J Clin Microbiol 40:3082-5. 2002
    Sera from 491 Korean patients with acute febrile diseases were tested for Ehrlichia chaffeensis and Anaplasma phagocytophila antibodies by indirect immunofluorescence assay (IFA), Western blotting, and TaqMan real-time PCR. Overall, 0...
  99. doi Cultivation and molecular identification of Ehrlichia canis and Ehrlichia chaffeensis from a naturally co-infected dog in Venezuela
    Clara N Gutiérrez
    Biomedical Research Institute BIOMED UC, Univresity of Carabobo campus Aragua, Maracay, Venezuela
    Vet Clin Pathol 37:258-65. 2008
    ..Diagnosis of canine ehrlichiosis in Venezuela is normally performed by examination of buffy coat smears (BCS). Characteristic inclusion bodies are frequently observed in leukocytes and platelets from dogs with clinical signs of the disease...
  100. ncbi Transmission of bacterial agents from lone star ticks to white-tailed deer
    Andrea S Varela-Stokes
    Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    J Med Entomol 44:478-83. 2007
    ..Among these bacteria are the disease agents Ehrlichia chaffeensis and Ehrlichia ewingii, and the putative disease agent "Borrelia lonestari...
  101. ncbi [First detection of Ehrlichiosis detected serologically and with the polymerase chain reaction in patients with borreliosis in the Czech Republic]
    D Hulinska
    Oddĕlení prírodních ohniskových nákaz Centra epidemiologie a mikrobiologie Státního zdravotního ústavu, Národní referencní laborator pro borreliózu, Praha
    Cas Lek Cesk 140:181-4. 2001
    ..From 37 goal-directed examinations done in years 1998-2000, bacteria Ehrlichia chaffeensis was found to be the cause of human monocytic ehrlichiosis (HME) in two patients who had stayed in Bulgaria,..

Research Grants81

  1. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
    ..mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.). The project is part of the mentored career development plan for Holly D. Gaff with J...
  2. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006
    ..ehrlichial disease reported in the USA to date, rely on better understanding of interactions between Ehrlichia chaffeensis, the etiologic agent, and its tick host...
  3. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2004
    ..goal of this research project is the elucidation of the mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  4. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2002
    ..These pathogens include ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E...
  5. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2007
    ..chaffeensis. ..
  6. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  7. Ehrlichia chaffeensis protective proteins
    David Walker; Fiscal Year: 2009
    ..chaffeensis. ..
  8. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
    ..from the Applicant's Abstract): Two tick-borne ehrlichioses, human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) caused by Ehrlichia equi or a closely related organism, have ..
  9. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 1999
    ..to elucidate the interaction of the human patient with the tick-borne, obligately intracellular bacterium Ehrlichia chaffeensis, particularly with the ehrlichial structural and functional components which stimulate protective immunity ..
  10. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2001
    ..The long-term goal of this research is the elucidation of the mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  11. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  12. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  13. EHRLICHIACIDAL MECHANISM BY LEUKOCYTES
    Yasuko Rikihisa; Fiscal Year: 2003
    ..Abstract): Recently, tick-borne diseases caused by infection with two new human ehrlichiosis agents: Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) agent are increasingly recognized in the U.S...
  14. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    b>Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  15. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2007
    b>Ehrlichia chaffeensis infects monocytes and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...
  16. COMPARISON OF 3 HUMAN EHRLICHIOSIS GENOME SEQUENCES
    Yasuko Rikihisa; Fiscal Year: 2002
    ..States, including a new granulocytotropic ehrlichia, the human granulocytic ehrlichiosis (HGE) agent, and Ehrlichia chaffeensis, a new monocytotropic ehrlichia causes human monocytic ehrlichiosis. E...
  17. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    b>Ehrlichia chaffeensis infects monocytes and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...