propionibacterium acnes

Summary

Summary: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.

Top Publications

  1. ncbi Propionibacterium acnes
    A L Perry
    Biomedical Sciences, School of Life and Heath Sciences, Aston University, Birmingham, UK
    Lett Appl Microbiol 42:185-8. 2006
  2. ncbi Propionibacterium acnes contamination in lumbar disc surgery
    A Carricajo
    Bacteriology Department, CHU Hospital Bellevue Saint Etienne, France
    J Hosp Infect 66:275-7. 2007
  3. doi A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
  4. pmc Comparative genomics and transcriptomics of Propionibacterium acnes
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University of Gottingen, Gottingen, Germany
    PLoS ONE 6:e21581. 2011
  5. pmc Genome sequence of Propionibacterium acnes type II strain ATCC 11828
    Balazs Horvath
    Institute for Plant Genomics, Human Biotechnology and Bioenergy, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
    J Bacteriol 194:202-3. 2012
  6. pmc Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA
    J Invest Dermatol 129:2480-8. 2009
  7. pmc Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium
    Mariko Negi
    Department of Human Pathology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Mod Pathol 25:1284-97. 2012
  8. doi Propionibacterium acnes: infection beyond the skin
    Alexandra Perry
    Eurofins Agroscience Services Ltd, Slade Lane, Wilson, Melbourne, Derbyshire, DE73 8AG, UK
    Expert Rev Anti Infect Ther 9:1149-56. 2011
  9. pmc Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne
    Hans B Lomholt
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e12277. 2010
  10. doi The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
    Clio Dessinioti
    Department of Dermatology, Andreas Sygros Hospital, University of Athens, 5, I Dragoumi Street, 16121, Athens, Greece
    Clin Dermatol 28:2-7. 2010

Detail Information

Publications266 found, 100 shown here

  1. ncbi Propionibacterium acnes
    A L Perry
    Biomedical Sciences, School of Life and Heath Sciences, Aston University, Birmingham, UK
    Lett Appl Microbiol 42:185-8. 2006
    b>Propionibacterium acnes, a common skin organism, is most notably recognized for its role in acne vulgaris...
  2. ncbi Propionibacterium acnes contamination in lumbar disc surgery
    A Carricajo
    Bacteriology Department, CHU Hospital Bellevue Saint Etienne, France
    J Hosp Infect 66:275-7. 2007
    Previous studies have shown that Propionibacterium acnes may be responsible for low-grade infection of the intervertebral discs of patients with severe sciatica...
  3. doi A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
    ..org/pacnes/) for Propionibacterium acnes based on the analysis of seven core housekeeping genes...
  4. pmc Comparative genomics and transcriptomics of Propionibacterium acnes
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University of Gottingen, Gottingen, Germany
    PLoS ONE 6:e21581. 2011
    The anaerobic gram-positive bacterium Propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P...
  5. pmc Genome sequence of Propionibacterium acnes type II strain ATCC 11828
    Balazs Horvath
    Institute for Plant Genomics, Human Biotechnology and Bioenergy, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
    J Bacteriol 194:202-3. 2012
    b>Propionibacterium acnes is an anaerobic Gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
  6. pmc Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA
    J Invest Dermatol 129:2480-8. 2009
    ..not been demonstrated whether lauric acid can be used for acne treatment as a natural antibiotic against Propionibacterium acnes (P. acnes), which promotes follicular inflammation (inflammatory acne)...
  7. pmc Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium
    Mariko Negi
    Department of Human Pathology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Mod Pathol 25:1284-97. 2012
    ..b>Propionibacterium acnes is the only microorganism, however, found in sarcoid lesions by bacterial culture...
  8. doi Propionibacterium acnes: infection beyond the skin
    Alexandra Perry
    Eurofins Agroscience Services Ltd, Slade Lane, Wilson, Melbourne, Derbyshire, DE73 8AG, UK
    Expert Rev Anti Infect Ther 9:1149-56. 2011
    b>Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P...
  9. pmc Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne
    Hans B Lomholt
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e12277. 2010
    The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin...
  10. doi The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
    Clio Dessinioti
    Department of Dermatology, Andreas Sygros Hospital, University of Athens, 5, I Dragoumi Street, 16121, Athens, Greece
    Clin Dermatol 28:2-7. 2010
    We have come a long way since 1896, when it was first suggested that Propionibacterium acnes, found in acne lesions, was the cause of acne...
  11. pmc Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny
    Rolf Lood
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Sweden
    BMC Genomics 12:198. 2011
    b>Propionibacterium acnes is a Gram positive rod inhabiting the human skin that also infects orthopaedic implants and is associated with acne vulgaris. Previously, one lytic bacteriophage, PA6, from P...
  12. ncbi Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light
    Helena Ashkenazi
    Health Sciences Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    FEMS Immunol Med Microbiol 35:17-24. 2003
    b>Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins...
  13. ncbi Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes
    Junko Minami
    Department of Human Pathology, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 50:265-74. 2003
    Etiology of sarcoidosis remains unknown. A trigger factor from Propionibacterium acnes causes a cellular immune response in some sarcoid patients but not in nonsarcoid subjects...
  14. pmc Beneficial or deleterious effects of a preexisting hypersensitivity to bacterial components on the course and outcome of infection
    Marina Gumenscheimer
    Max Planck Institut fur Immunbiologie, 79 108 Freiburg, Germany
    Infect Immun 70:5596-603. 2002
    Priming with heat-killed Propionibacterium acnes enhances the sensitivity of mice to lipopolysaccharide (LPS) and other biologically active bacterial components. We show that P...
  15. doi A new phylogenetic group of Propionibacterium acnes
    Andrew McDowell
    School of Medicine and Dentistry, Queen s University, Belfast BT12 6BN, UK
    J Med Microbiol 57:218-24. 2008
    Immunofluorescence microscopy-based identification of presumptive Propionibacterium acnes isolates, using the P. acnes-specific mAb QUBPa3, revealed five organisms with an atypical cellular morphology...
  16. ncbi Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002
    One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes; yet, the molecular mechanism by which P. acnes induces inflammation is not known...
  17. pmc Histone H4 is a major component of the antimicrobial action of human sebocytes
    Dong Youn Lee
    Division of Dermatology, University of California San Diego and VA San Diego Healthcare Center, San Diego, California, USA
    J Invest Dermatol 129:2489-96. 2009
    ..aureus and Propionibacterium acnes. In addition, histone H4 enhanced the antimicrobial action of free fatty acids in human sebum...
  18. doi Characterization of Propionibacterium acnes isolates from sarcoid and non-sarcoid tissues with special reference to cell invasiveness, serotype, and trigger factor gene polymorphism
    Asuka Furukawa
    Department of Human Pathology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Microb Pathog 46:80-7. 2009
    Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism so far isolated from sarcoid lesions. To examine whether P...
  19. ncbi In situ localization of Propionibacterium acnes DNA in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter deposition
    Tetsuo Yamada
    Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Pathol 198:541-7. 2002
    Sarcoidosis is a systemic granulomatous disease of unknown aetiology. Many genomes of Propionibacterium acnes and P. granulosum have been detected in lymph nodes from patients with sarcoidosis...
  20. ncbi Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis
    Ikuo Ishige
    Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 22:33-42. 2005
    In studies of the unknown etiology of sarcoidosis, Propionibacterium acnes (a possible agent) was found in the lungs and lymph nodes of many sarcoidosis patients and some control subjects. P...
  21. ncbi Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytes
    V Jarrousse
    INSERM U601, 9 quai Moncousu, 44093 Nantes Cedex 01, France
    Arch Dermatol Res 299:441-7. 2007
    b>Propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne...
  22. pmc Propionibacterium acnes and Staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogens
    Sadia A Niazi
    Dental Institute, King s College London, London, England
    J Clin Microbiol 48:3859-69. 2010
    ..from 20 refractory endodontic lesions (9 with abscesses and 11 without abscesses) were determined, and Propionibacterium acnes and Staphylococcus epidermidis were among the most predominant organisms...
  23. doi Genetic diversity of Propionibacterium acnes strains isolated from human skin in Japan and comparison with their distribution in Europe
    Itaru Dekio
    Skin Microbe Laboratory, Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Japan
    J Med Microbiol 61:622-30. 2012
    b>Propionibacterium acnes, a commensal of human skin, is also an opportunistic pathogen of common acne and certain infectious diseases...
  24. pmc An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 7:e41480. 2012
    The Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota and is associated with various infections and clinical conditions...
  25. doi A microbial aetiology of acne: what is the evidence?
    B Shaheen
    Department of Dermatology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Br J Dermatol 165:474-85. 2011
    ..There is considerable evidence, circumstantial at best, which suggests that micro-organisms, particularly Propionibacterium acnes, are important in the pathogenesis of acne vulgaris. However, it is still unclear whether P...
  26. pmc Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice
    Tetsu Nishiwaki
    Department of Molecular Preventive Medicine and Solution Oriented Research for Science and Technology, The University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Pathol 165:631-9. 2004
    ..We report here that extrapulmonary sensitization to Propionibacterium acnes, which is one of the candidates to date, induced pulmonary Th-1 granulomas mainly in the subpleural and ..
  27. doi Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants
    Meike Sörensen
    Max Planck Institute for Infection Biology, Department of Molecular Biology, D 10117 Berlin, Germany
    J Microbiol Methods 83:211-6. 2010
    ..acnes. The here presented insertional mutagenesis approach will facilitate future studies on P. acnes...
  28. doi Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes
    Sandrine Tchaptchet
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 40:2506-16. 2010
    b>Propionibacterium acnes is a human commensal but also an opportunistic pathogen. In mice, P. acnes exerts strong immunomodulatory activities, including formation of intrahepatic granulomas and induction of LPS hypersensitivity...
  29. pmc Complete genome sequences of three Propionibacterium acnes isolates from the type IA(2) cluster
    Andrea Vörös
    Bay Zoltán Nonprofit Ltd, Szeged, Hungary
    J Bacteriol 194:1621-2. 2012
    b>Propionibacterium acnes is an anaerobic Gram-positive bacterium that has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
  30. doi Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells
    Lina Fassi Fehri
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Int J Med Microbiol 301:69-78. 2011
    ..Recent work has detected the anaerobic Gram-positive bacterium Propionibacterium acnes in cancerous prostates, but with wide-ranging detection rates...
  31. pmc TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    Kenshi Yamasaki
    Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 131:688-97. 2011
    ..These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea...
  32. ncbi Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes
    Mullika Traidej Chomnawang
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand
    Fitoterapia 78:401-8. 2007
    The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P...
  33. doi Rapid detection and quantification of Propionibacteriaceae
    P Goldschmidt
    Laboratoire du Centre National d Ophtalmologie des Quinze Vingts, 28 rue de Charenton, Paris, France
    Br J Ophthalmol 93:258-62. 2009
    ..The PCR cycling programme consisted of one cycle at 95 degrees C, 20 s and 45 cycles at 95 degrees C, 3 s and 30 s at 60 degrees C. DNA extraction yields were assessed in the same tube...
  34. ncbi Resveratrol inhibition of Propionibacterium acnes
    John J Docherty
    Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    J Antimicrob Chemother 59:1182-4. 2007
    To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.
  35. doi An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
    A C Jahns
    Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
    Br J Dermatol 167:50-8. 2012
    Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne.
  36. pmc Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes
    Mogens Kilian
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 50:1158-65. 2012
    b>Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals...
  37. ncbi Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes
    S Ramstad
    Department of Physics, Norwegian University of Science and Technology, Dragvoll, Norway
    J Photochem Photobiol B 40:141-8. 1997
    ..We have investigated whether or not similar changes can be induced in prokaryotes. The skin bacterium Propionibacterium acnes was sensitized using protoporphyrin IX (PP IX) or 5-aminolevulinic acid (ALA)...
  38. ncbi Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblasts
    Jee Young Choi
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea
    J Invest Dermatol 128:846-54. 2008
    b>Propionibacterium acnes (P. acnes) is a commensal microorganism found in sebum-rich skin and plays a role in acne inflammation by stimulating keratinocyte to produce a number of proinflammatory cytokines. However, the role of P...
  39. pmc Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Invest Dermatol 130:985-94. 2010
    ..The supernatant of FFA-incubated sebocyte culture showed antimicrobial activity against Propionibacterium acnes, whereas the enhanced antimicrobial activity of human sebocytes was neutralized by anti-hBD-2 IgG...
  40. pmc Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes
    Rolf Lood
    Department of Clinical Sciences, Division of Infection Medicine, BMC B14, Lund University, SE 221 84 Lund, Sweden
    BMC Microbiol 8:139. 2008
    b>Propionibacterium acnes is a commensal of human skin but is also known to be involved in certain diseases, such as acne vulgaris and infections of orthopaedic implants...
  41. ncbi Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, USA
    Dermatology 211:193-8. 2005
    ..One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes; yet, the molecular mechanism by which P. acnes induces inflammation is not known...
  42. ncbi Pathogenesis of acne
    M Toyoda
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Med Electron Microsc 34:29-40. 2001
    ..of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by Propionibacterium acnes, which promotes perifollicular inflammation...
  43. ncbi Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy
    Uta Jappe
    Department of Dermatology and Venereology, University of Heidelberg, Germany
    Acta Derm Venereol 83:241-8. 2003
    ..b>Propionibacterium acnes releases pro-inflammatory cytokines as well as antigens and mitogen(s), with cellular and non-cellular ..
  44. ncbi Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes
    Tsuyoshi Tanabe
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Biochim Biophys Acta 1762:794-801. 2006
    ..We found that intracellular Propionibacterium acnes, a possible causative agent of sarcoidosis, activated NF-kappaB in both NOD1- and NOD2-dependent manners...
  45. ncbi Induction of toll-like receptors by Propionibacterium acnes
    S Jugeau
    INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
    Br J Dermatol 153:1105-13. 2005
    The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity...
  46. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..Administration of anti-IGIF antibodies prevents liver damage in mice inoculated with Propionibacterium acnes and challenged with lipopolysaccharide, which induces toxic shock...
  47. ncbi The complete genome sequence of Propionibacterium acnes, a commensal of human skin
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Science 305:671-3. 2004
    b>Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation...
  48. doi In vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalis
    Chieh Yu Pan
    Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan
    Peptides 30:1058-68. 2009
    ..We studied the in vitro activities of epinecidin-1(22-42), csSALF(55-76), and lsSALF(55-76) against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalis...
  49. pmc Proteomic identification of secreted proteins of Propionibacterium acnes
    Carsten Holland
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    BMC Microbiol 10:230. 2010
    The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a ..
  50. pmc Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes
    Dong Youn Lee
    J Invest Dermatol 128:1863-6. 2008
  51. pmc Skin microbiota: a source of disease or defence?
    A L Cogen
    Department of Bioengineering, Division of Dermatology, School of Medicine, University of California, San Diego, CA, USA
    Br J Dermatol 158:442-55. 2008
    ..Specifically, the review will discuss our current understanding of the cutaneous microbiota as well as shifting paradigms in the interpretation of the roles microbes play in skin health and disease...
  52. pmc Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
    PLoS ONE 3:e1551. 2008
    ..people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P...
  53. doi Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates
    A Holmberg
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, 221 84 Lund, Sweden
    Clin Microbiol Infect 15:787-95. 2009
    b>Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. Bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and P...
  54. doi MALDI-TOF MS fingerprinting facilitates rapid discrimination of phylotypes I, II and III of Propionibacterium acnes
    Elisabeth Nagy
    Hungarian Anaerobe Reference Laboratory, Institute of Clinical Microbiology, University of Szeged, 6725 Szeged, Semmelweis u 6, Hungary
    Anaerobe 20:20-6. 2013
    ..b>Propionibacterium acnes is frequently referred to as an anaerobic skin commensal of relatively low pathogenicity...
  55. ncbi Propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin CD9
    Hiroyuki Yamane
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Pathol 206:486-92. 2005
    ..When intrahepatic granulomas were induced by intravenous injection of Propionibacterium acnes, hepatocyte CD9 was extensively upregulated, while inflammatory cells constituting granulomas were mostly ..
  56. doi Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation
    Tim N Mak
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    Cell Microbiol 14:1720-33. 2012
    The contribution of the human microbiota to health and disease is poorly understood. Propionibacterium acnes is a prominent member of the skin microbiota, but is also associated with acne vulgaris...
  57. pmc Draft genome sequence of an antibiotic-resistant Propionibacterium acnes strain, PRP-38, from the novel type IC cluster
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    J Bacteriol 194:3260-1. 2012
    b>Propionibacterium acnes, a non-spore-forming, anaerobic gram-positive bacterium, is most notably recognized for its association with acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009)...
  58. doi Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis
    Mi Sun Kang
    Department of Microbiology, School of Medicine, Chonnam National University, Gwangju, 501 746, Republic of Korea
    J Microbiol 50:137-42. 2012
    While it is generally accepted that Propionibacterium acnes is involved in the development of acne, other bacteria including Staphylococcus epidermidis have also been isolated from the acne lesion...
  59. ncbi Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection
    Roger Bayston
    Biomaterials Related Infection Group, School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK
    J Antimicrob Chemother 60:1298-301. 2007
    b>Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated...
  60. pmc Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization
    Itai Sharon
    Department of Earth and Planetary Science, UC Berkeley, Berkeley, California 94720, USA
    Genome Res 23:111-20. 2013
    ..At the species level, we observed the decline of an early-colonizing Propionibacterium acnes strain similar to SK137 and the proliferation of novel Propionibacterium and Peptoniphilus species late ..
  61. doi A descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery
    Karim Saleh
    Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden
    Dermatol Surg 37:1014-22. 2011
    ..The pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors...
  62. pmc The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes
    Darren Yang
    Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 30:6035-40. 2009
    This study evaluated the antimicrobial activity of lauric acid (LA) and its liposomal derivatives against Propionibacterium acnes (P. acnes), the bacterium that promotes inflammatory acne...
  63. ncbi The evolving role of Propionibacterium acnes in acne
    J J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    Semin Cutan Med Surg 20:139-43. 2001
    b>Propionibacterium acnes is a member of the resident cutaneous flora. Sebaceous follicles involved in acne are characterized by the accumulation of abnormally desquamated corneocytes and excess sebum-the microcomedo...
  64. doi A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes
    Debika Biswal Shinohara
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 73:1007-15. 2013
    ..To study this potential link in an in vivo system, we developed a mouse model of long-term bacteria-induced chronic inflammation of the prostate using a human prostatectomy-derived strain of Propionibacterium acnes.
  65. pmc Propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cells
    Johanna B Drott
    Department of Clinical Microbiology Virology, Umea University, SE 901 87 Umea, Sweden
    BMC Microbiol 10:126. 2010
    The immune stimulating bacterium Propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. To understand the pathogenesis of the earliest phase of this infection, we examined the P...
  66. ncbi Role of monocyte chemoattractant protein-1 in Propionibacterium acnes-induced pulmonary granulomatosis
    H Ichiyasu
    First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Microsc Res Tech 53:288-97. 2001
    ..we developed a model using sensitized rabbits for T cell-mediated pulmonary granulomatosis induced by Propionibacterium acnes (P...
  67. doi Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes
    Yuko Takenaka
    Department of Dermatology, Tokyo Women s Medical University, Tokyo, Japan
    J Dermatol 39:350-4. 2012
    ..To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time-kill method...
  68. doi Multilocus sequence typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens
    Tim N Mak
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Prostate 73:770-7. 2013
    ..The pro-inflammatory anaerobe, Propionibacterium acnes, is ubiquitously found on human skin and is associated with the skin disease acne vulgaris...
  69. ncbi Quantitative PCR of Propionibacterium acnes DNA in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne
    Yuriko Miura
    Fukasawa Dermatology Clinic, Kanagawa, Japan
    J Med Dent Sci 57:65-74. 2010
    To elucidate whether people with hair follicles containing many Propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of P. acnes in hair follicles...
  70. pmc Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses
    Kenshiro Tsuda
    Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
    PLoS ONE 6:e29020. 2011
    ..b>Propionibacterium acnes (P. acnes) is an aerotolerant anaerobic gram-positive bacteria that causes acne and inflammation...
  71. ncbi Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils
    A Jain
    Department of Microbiology, King George s Medical College, Lucknow 226003, India
    Dermatol Online J 8:2. 2002
    b>Propionibacterium acnes (P. acnes), an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing neutrophil chemotactic factors (NCF)...
  72. pmc Clinical significance of Propionibacterium acnes recovered from blood cultures: analysis of 524 episodes
    Hyun Jung Park
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Republic of Korea
    J Clin Microbiol 49:1598-601. 2011
    Of 522 patients with Propionibacterium acnes bacteremia (PAB), 18 (3.5%) had clinically significant PAB. Of these 18 patients, 10 (55.6%) had hospital-acquired bacteremia and 6 (33...
  73. ncbi Modulatory effect of killed Propionibacterium acnes and its purified soluble polysaccharide on peritoneal exudate cells from C57Bl/6 mice: major NKT cell recruitment and increased cytotoxicity
    R Z Ananias
    Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Scand J Immunol 65:538-48. 2007
    b>Propionibacterium acnes has been described as a potent adjuvant to immune responses in vitro and in vivo. Presently, we analysed the modulation of peritoneal exudate cells (PEC) by heat-killed P...
  74. pmc Susceptibilities of Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime
    Robert Shames
    Division of Infectious Disease, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042, USA
    J Clin Microbiol 44:4227-8. 2006
    We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1...
  75. ncbi TNF-alpha hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice
    T Merlin
    , Freiburg, Germany
    J Endotoxin Res 7:157-63. 2001
    ..Using Lps(n) BALB/c and Lps(d) BALB/c/l mice, primed with Propionibacterium acnes or infected with Salmonella typhimurium, we show that concurrently to hypersensitivity to LPS, a ..
  76. ncbi Propionibacterium acnes DNA detected in bronchoalveolar lavage cells from patients with sarcoidosis
    Jun ichi Hiramatsu
    Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 20:197-203. 2003
    The causes of sarcoidosis are unknown. Propionibacterium acnes is so far the only bacterium to be found in sarcoid lymph nodes. We attempted to detect P...
  77. ncbi Propionibacterium acnes biotypes and susceptibility to minocycline and Keigai-rengyo-to
    Shuichi Higaki
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi 930 0194, Japan
    Int J Dermatol 43:103-7. 2004
    b>Propionibacterium acnes is the predominant organism in acne lesions, but the sensitivity of different biotypes of P. acnes to therapeutic agents has seldom been reported.
  78. pmc Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid
    Eva Rosberg-Cody
    Teagasc, Moorepark Food Research, Biotechnology Centre, Fermoy, Co Cork, Ireland
    Microbiology 153:2483-90. 2007
    The linoleic acid isomerase enzyme from Propionibacterium acnes responsible for bioconversion of linoleic acid to trans-10, cis-12 conjugated linoleic acid (t10, c12 CLA) was cloned and overexpressed in Lactococcus lactis and Escherichia ..
  79. ncbi Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55. 1999
    ..was designed to investigate the role of IFN-gamma in LPS-induced liver injury following priming with Propionibacterium acnes. At 1 week after priming BALB/c mice with P...
  80. doi Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis
    Hiroshi Kitagawa
    Exp Dermatol 20:157-8. 2011
    Atopic dermatitis (AD) is a chronic disease characterized by a polarized Th2 immune response. Propionibacterium acnes (P. acnes) has been shown to elicit strong Th1 immune responses. We hypothesized that the host immune response to P...
  81. ncbi Neolitsea aciculata essential oil inhibits drug-resistant skin pathogen growth and Propionibacterium acnes-induced inflammatory effects of human monocyte leukemia
    Sang Suk Kim
    Department Department of Chemistry, Cheju National University, Ara l dong, Jeju 690 756, Korea
    Nat Prod Commun 6:1193-8. 2011
    ..NAE exhibited moderate to strong antibacterial activity against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are known as acne-causing bacteria. In addition, NAE reduced the P...
  82. ncbi Roles of CD14 in LPS-induced liver injury and lethality in mice pretreated with Propionibacterium acnes
    Yoshihiro Shuto
    Department of Immunonology and Allergy, Oita University Medical School, Hasama machi, Oita 879 5593, Japan
    Immunol Lett 94:47-55. 2004
    The mechanism of the liver damage and lethality in Propionibacterium acnes (P. acnes)-LPS system remains obscure...
  83. doi Propionibacterium acnes brain abscess appearing 10 years after neurosurgery
    Sarah M Kranick
    Hospital of University of Pennsylvania, Department of Neurology, 3 W Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Neurol 66:793-5. 2009
    To describe a case of Propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment.
  84. pmc Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California 92161, USA
    J Invest Dermatol 128:2451-7. 2008
    b>Propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. We examined whether vaccination against P. acnes suppressed P. acnes-induced skin inflammation. Inactivation of P...
  85. pmc Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo
    Teruaki Nakatsuji
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA, USA
    Proteomics 8:3406-15. 2008
    ..Unlike humans, most animals produce little or no triglycerides in hair follicles to harbor Propionibacterium acnes a fact that has encumbered the development of novel treatments for acne lesions...
  86. ncbi Protective effects of radix Rosa laevigata against Propionibacterium acnes and lipopolysaccharide-induced liver injury
    Rong rong He
    School of Traditional Chinese Materia Medicine, Shengyang Pharmaceutical University, Shengyang, China
    Biosci Biotechnol Biochem 73:1129-36. 2009
    We investigated the effects of an extract of Radix Rosa laevigata (R. R. laevigata) on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced acute liver injury...
  87. doi Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris
    Natsumi Ishida
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
    Microbiol Immunol 52:621-4. 2008
    Antibiotic susceptibilities of Propionibacterium acnes in Japan were determined. Erythromycin-resistance was found in 10.4% (5/48) of the strains, and four of these were cross-resistance to clindamycin...
  88. ncbi Propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection
    M Nisbet
    Infectious Disease Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
    J Antimicrob Chemother 60:1097-103. 2007
    b>Propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. This review of patients with P...
  89. ncbi The Propionibacterium acnes genome: from the laboratory to the clinic
    Ted Rosen
    Dermatology, Baylor College of Medicine, Houston, TX, USA
    J Drugs Dermatol 6:582-6. 2007
    The genome of Propionibacterium acnes, the microbe presumed to be at least partially etiologic for the development of acne, has recently been decoded...
  90. pmc Inhibition of propionibacterium acnes by bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius
    Whitney P Bowe
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Drugs Dermatol 5:868-70. 2006
    We report the in vitro inhibition of Propionibacterium acnes (P. acnes) by a bacteriocin-like inhibitory substance (BLIS-like substance) produced by Streptococcus salivarius (S. salivarius)...
  91. doi Propionibacterium acnes as an etiological agent of arthroplastic and osteosynthetic infections--two cases with specific clinical presentation including formation of draining fistulae
    B Soderquist
    Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, Orebro, Sweden
    Anaerobe 16:304-6. 2010
    ..b>Propionibacterium acnes was isolated in multiple cultures in both cases...
  92. doi Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
    Bong Seon Kang
    Department of Dermatology, Kangnam St Mary s Hospital, Seoul 137 040, Republic of Korea
    J Microbiol 47:101-9. 2009
    ..antimicrobial activity against Gram-positive pathogens assayed, especially the highest activity against Propionibacterium acnes. The antimicrobial substance was purified and verified as a bacteriocin (named ESL5) of E...
  93. ncbi Effect of adjunctive treatment with intravenously administered Propionibacterium acnes on reproductive performance in mares with persistent endometritis
    Barton W Rohrbach
    Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Am Vet Med Assoc 231:107-13. 2007
    To determine whether treatment with a preparation of Propionibacterium acnes would improve pregnancy and live foal rates in mares with persistent endometritis.
  94. doi Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro
    F H Al-Ghazzewi
    Glycologic Limited, c o Glasgow Caledonian University, Glasgow, U K
    Int J Cosmet Sci 32:139-42. 2010
    ..of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro...
  95. doi The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells
    Anna Michalak-Stoma
    Department of Clinical Immunology, Medical University of Lublin, Poland
    Folia Histochem Cytobiol 46:535-9. 2008
    b>Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder...
  96. pmc On the mechanism of a polyunsaturated fatty acid double bond isomerase from Propionibacterium acnes
    Alena Liavonchanka
    Department for Plant Biochemistry, Albrecht von Haller Institute for Plant Sciences, Goettingen, Germany
    J Biol Chem 284:8005-12. 2009
    The catalytic mechanism of Propionibacterium acnes polyunsaturated fatty acid isomerase (PAI) is explored by kinetic, spectroscopic, and thermodynamic studies...
  97. ncbi Heat shock proteins and inflammatory acne vulgaris: molecular cloning, overexpression and purification of a propionibacterium acnes GroEL and DnaK homologue
    M D Farrar
    Skin Research Centre, Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK
    FEMS Microbiol Lett 191:183-6. 2000
    b>Propionibacterium acnes is associated with inflammatory acne. The genes encoding two putative mediators of inflammation, the heat shock proteins GroEL and DnaK, were cloned from this organism and sequenced...
  98. ncbi Propionibacterium acnes resistance: a worldwide problem
    E A Eady
    University of Leeds, Leeds, UK
    Dermatology 206:54-6. 2003
    Antibiotic therapy directed against Propionibacterium acnes has been a mainstay of treatment for more than 40 years. Despite years of widespread use of systemic tetracyclines and erythromycin, change in P...
  99. ncbi Antibiotic resistance of Propionibacterium acnes in acne vulgaris
    Jil K Swanson
    Department of Dermatology, University of Pittsburgh Physicians, Pittsburgh, PA, USA
    Dermatol Nurs 15:359-62. 2003
    ..Antibiotics remain the most common prescribed agent for the treatment of acne. Improper use of antibiotics in the dermatological setting needs to be evaluated to prevent the increasing prevalence of antibiotic resistance...
  100. ncbi Increases in cytokine and antimicrobial peptide gene expression in horses by immunomodulation with Propionibacterium acnes
    Elizabeth G Davis
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA
    Vet Ther 4:5-11. 2003
    Immunomodulation with Propionibacterium acnes is used for prophylaxis of respiratory disease or in horses suffering from chronic pulmonary inflammation; however, the mechanism for this response is poorly understood...
  101. doi The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation
    M Sharma
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Phytother Res 25:517-21. 2011
    Acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium Propionibacterium acnes. The possibility was investigated that a standardized preparation of Echinacea purpurea (Echinaforce®), with known ..

Research Grants46

  1. 5-Naphthoylsalicylanilides as improved anti-acne agents
    Richard Evans; Fiscal Year: 2007
    ..These include: 1) a broad spectrum of antibacterial activity, with exceptional activity against Propionibacterium acnes (a significant factor in the progression of acne) as well as other dermal pathogens such as ..
  2. GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    Robert Modlin; Fiscal Year: 2007
    ..The increase in antibiotic-resistant strains of Propionibacterium acnes, the bacterium that contributes to the pathogenesis of acne, has hastened research for development of ..
  3. GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    Robert Modlin; Fiscal Year: 2009
    ..The increase in antibiotic-resistant strains of Propionibacterium acnes, the bacterium that contributes to the pathogenesis of acne, has hastened research for development of ..
  4. Transfusion Medicine/Hemostasis Clinical Trials Network
    Mark Brecher; Fiscal Year: 2007
    ..Two TMH CTN protocols are ongoing at UNC, and it is the intention of the investigators at this site to support new network protocols in the future. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CRITIQUES ..
  5. Innate Immunity in Acne Vulgaris
    Jenny J Kim; Fiscal Year: 2010
    ....
  6. Innate and Adaptive Immunity in Acne Vulgaris
    Jenny Kim; Fiscal Year: 2006
    ..In inflammatory acne, Propionibacterium acnes plays a key role in eliciting host inflammatory response that is thought to be important for the ..
  7. Effect of Zinc in Attaching and Effacing E. coli Infection
    JOHN K contact CRANE; Fiscal Year: 2010
    ..Zinc inhibits the virulence of both of these groups of E. coli, and we wish to study zinc further to see if it could be used as a treatment for these infections. ..
  8. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..coli (RDEC-1) and rabbit EPEC (REPEC). ..
  9. Enteropathogenic and Toxigenic E.coli Interactions
    JOHN CRANE; Fiscal Year: 2004
    ..abstract_text> ..
  10. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
    ..abstract_text> ..
  11. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  12. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2007
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. ..
  13. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    ..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
  14. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2007
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  15. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  16. Physical Activity, Aging and Immune Function
    Jeffrey Woods; Fiscal Year: 2005
    ..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..