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| mycobacterium tuberculosisSummarySummary: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation. Top Publications
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Publications
Rapid molecular detection of tuberculosis and rifampin resistanceCatharina C Boehme
Foundation for Innovative New Diagnostics, Geneva, Switzerland
N Engl J Med 363:1005-15. 2010..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesMaximiliano G Gutierrez
Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo-CONICET, Mendoza 5500, Argentina
Cell 119:753-66. 2004b>Mycobacterium tuberculosis is an intracellular pathogen persisting within phagosomes through interference with phagolysosome biogenesis...- An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosisMatthew P R Berry
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 466:973-7. 2010Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment... - HIV infection and multidrug-resistant tuberculosis: the perfect stormCharles D Wells
Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:S86-107. 2007..The global human immunodeficiency virus (HIV) infection epidemic has caused explosive increases in TB incidence and may be contributing to increases in MDR-TB prevalence... - Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceS T Cole
Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
Nature 393:537-44. 1998..The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this .. 
The spectrum of latent tuberculosis: rethinking the biology and intervention strategiesClifton E Barry
Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Microbiol 7:845-55. 2009..biology of latent tuberculosis as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide ..- High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demographyRuth Hershberg
Department of Biology, Stanford University, Stanford, California, USA
PLoS Biol 6:e311. 2008b>Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds... - Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technologyDanica Helb
Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry, New Jersey, Newark, New Jersey 07103, USA
J Clin Microbiol 48:229-37. 2010Current nucleic acid amplification methods to detect Mycobacterium tuberculosis are complex, labor-intensive, and technically challenging... - An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionJ L Flynn
Howard Hughes Medical Institute, Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461
J Exp Med 178:2249-54. 1993..Upon infection with Mycobacterium tuberculosis, although they develop granulomas, gko mice fail to produce reactive nitrogen intermediates and are .. - Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosisPhilip Supply
INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
J Clin Microbiol 44:4498-510. 2006..adopted in combination with spoligotyping as the basis for large-scale, high-throughput genotyping of Mycobacterium tuberculosis. However, even the combination of these two methods is still less discriminatory than IS6110 .. - Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responsePhilip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006..genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to .. - Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repairMaziar Divangahi
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 10:899-906. 2009Induction of macrophage necrosis is a strategy used by virulent Mycobacterium tuberculosis (Mtb) to avoid innate host defense... - The role of the granuloma in expansion and dissemination of early tuberculous infectionJ Muse Davis
Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
Cell 136:37-49. 2009..Our direct observations provide insight into how pathogenic mycobacteria exploit the granuloma during the innate immune phase for local expansion and systemic dissemination... - The population dynamics and control of tuberculosisChristopher Dye
World Health Organization, CH1211 Geneva 27, Switzerland
Science 328:856-61. 2010..Here we review the changing relationship between the causative agent, Mycobacterium tuberculosis, and its human host and examine a range of factors that could explain the persistence of TB... - Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation studyCatharina C Boehme
Foundation for Innovative New Diagnostics, Geneva, Switzerland
Lancet 377:1495-505. 2011..We aimed to assess operational feasibility, accuracy, and effectiveness of implementation in such settings... - Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection - United States, 2010Gerald H Mazurek
Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, CDC, Atlanta, GA 30333, USA
MMWR Recomm Rep 59:1-25. 2010..Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR;54[No. RR-15]:49-55)... - Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infectionNadia Caccamo
Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, University of Palermo, Palermo, Italy
Eur J Immunol 40:2211-20. 2010Th1 CD4(+) T cells and their derived cytokines are crucial for protection against Mycobacterium tuberculosis. Using multiparametric flow cytometry, we have evaluated the distribution of seven distinct functional states (IFN-γ/IL-2/TNF-α .. - Understanding latent tuberculosis: a moving targetPhilana Ling Lin
Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
J Immunol 185:15-22. 2010Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection... - Toll-like receptors control autophagyMonica A Delgado
Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
EMBO J 27:1110-21. 2008.... - The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosisMaxine Caws
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
PLoS Pathog 4:e1000034. 2008..We hypothesized that some strains of Mycobacterium tuberculosis (M... - IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeShabaana A Khader
Trudeau Institute, Saranac Lake, New York 12983, USA
Nat Immunol 8:369-77. 2007Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection... - Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in miceEmily K Forbes
The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
J Immunol 181:4955-64. 2008Boosting bacillus Calmette-Guérin (BCG)-primed mice with a recombinant adenovirus expressing Mycobacterium tuberculosis Ag 85A by different administration routes has very different effects on protection against aerosol challenge with M... - Tuberculosis: what we don't know can, and does, hurt usDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Science 328:852-6. 2010b>Mycobacterium tuberculosis has a penetrance of its host population that would be the envy of most human pathogens... - Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolutionHolly R Ramage
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
PLoS Genet 5:e1000767. 2009..genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M... - Toll-like receptor 4 is a sensor for autophagy associated with innate immunityYi Xu
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Immunity 27:135-44. 2007..We further showed that LPS-induced autophagy could enhance mycobacterial colocalization with the autophagosomes. This study links two ancient processes, autophagy and innate immunity, together through a shared signaling pathway... - Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individualsClare R Sander
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK
Am J Respir Crit Care Med 179:724-33. 2009..An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care... - Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulenceHuixian Gan
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 9:1189-97. 2008Macrophages infected with attenuated Mycobacterium tuberculosis strain H37Ra become apoptotic, which limits bacterial replication and facilitates antigen presentation... - Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primatesLaura E Via
Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
Infect Immun 76:2333-40. 2008Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens... - Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinasesSladjana Prisic
Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:7521-6. 2010The Mycobacterium tuberculosis genome encodes 11 serine/threonine protein kinases (STPKs) that are structurally related to eukaryotic kinases... - Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasisAnil Koul
Departments of Antimicrobial Research and Functional Genomics, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
J Biol Chem 283:25273-80. 2008An estimated one-third of the world population is latently infected with Mycobacterium tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-tuberculosis drugs, such as isoniazid... - Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37RvHuaJun Zheng
State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences, Fudan University, Shanghai, China
PLoS ONE 3:e2375. 2008Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M... - Cell-mediated immune responses in tuberculosisAndrea M Cooper
Trudeau Institute, Saranac Lake, New York 12983, USA
Annu Rev Immunol 27:393-422. 2009..Upon aerosol infection with Mycobacterium tuberculosis (Mtb), the acquired cellular immune response is slow to be induced and to be expressed within the lung... - Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South AfricaIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Infect Dis 51:823-9. 2010..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa... - Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosisShahin Shafiani
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
J Exp Med 207:1409-20. 2010The ability of the adaptive immune system to restrict Mycobacterium tuberculosis (Mtb) is impeded by activated Foxp3(+) regulatory T (T reg) cells. The importance of pathogen-specific T reg cells in this process has not been addressed... - An antimicrobial activity of cytolytic T cells mediated by granulysinS Stenger
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
Science 282:121-5. 1998..Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the .. - Fluoroquinolones, tuberculosis, and resistanceAmy Sarah Ginsburg
Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Lancet Infect Dis 3:432-42. 2003..However, there is concern about the development of fluoroquinolone resistance in Mycobacterium tuberculosis, particularly when administered as monotherapy or as the only active agent in a failing multidrug .. - The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesisPeter B Kang
Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
J Exp Med 202:987-99. 2005b>Mycobacterium tuberculosis (M.tb) survives in macrophages in part by limiting phagosome-lysosome (P-L) fusion. M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation... - Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pyloriSonja I Gringhuis
Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
Nat Immunol 10:1081-8. 2009..Mannose-expressing Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) induced the recruitment of effector proteins to the DC-.. - Why is long-term therapy required to cure tuberculosis?Lynn E Connolly
Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS Med 4:e120. 2007 - Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque modelPhilana Ling Lin
Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
Infect Immun 77:4631-42. 2009We previously described that low-dose Mycobacterium tuberculosis infection in cynomolgus macaques results in a spectrum of disease similar to that of human infection: primary disease, latent infection, and reactivation tuberculosis (S. V... - The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosisMarcela Parra
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm. 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Infect Immun 72:6799-805. 2004The heparin-binding hemagglutinin (HBHA) of Mycobacterium tuberculosis is a surface-expressed adhesin that can affect binding to host cells via a unique, methylated, carboxyl-terminal, lysine-, alanine-, and proline-rich repeat region... - Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiologyKarine Brudey
, Institut Pasteur de Guadeloupe, Guadeloupe
BMC Microbiol 6:23. 2006BACKGROUND: The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family... - Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapyGillian L Dean
St Thomas' Hospital, London, UK
AIDS 16:75-83. 2002..e. after 2 months) for patients who are clinically stable (CD4 > 100 x 106 cells/l)... - Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosisMichael Strong
Howard Hughes Medical Institute, UCLA Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:8060-5. 2006..by the structural determination of a previously unknown complex between a PE and PPE protein from the Mycobacterium tuberculosis genome, members of protein families that constitute approximately 10% of the coding capacity of this .. - Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /betaC Manca
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 98:5752-7. 2001..disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates... - TB database: an integrated platform for tuberculosis researchT B K Reddy
Department of Biochemistry, Stanford University, CA 94305, USA
Nucleic Acids Res 37:D499-508. 2009..The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M... - Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungsAndrea J Wolf
Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 205:105-15. 2008The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed compared with that of other infections or immunization, and allows the bacterial population in the lungs to expand markedly during the preimmune phase of .. - CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibitionDaniel L Barber
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 186:1598-607. 2011Although CD4 T cells are required for host resistance to Mycobacterium tuberculosis, they may also contribute to pathology. In this study, we examine the role of the inhibitory receptor PD-1 and its ligand PD-L1 during M... - Mycobacterium tuberculosis and the environment within the phagosomeKyle Rohde
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Immunol Rev 219:37-54. 2007..b>Mycobacterium tuberculosis infects macrophages through arresting the normal maturation process of the phagosome, retaining its .. - Definition of the Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markersKristin Kremer
Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands
J Clin Microbiol 42:4040-9. 2004b>Mycobacterium tuberculosis Beijing genotype strains are highly prevalent in Asian countries and in the territory of the former Soviet Union... - The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem studyTed Cohen
Division of Global Health Equity, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 7:e1000296. 2010..We conducted limited autopsies on young adults dying in a single public hospital in the province of KwaZulu-Natal between October 2008 and August 2009 in order to estimate the magnitude of deaths attributable to tuberculosis... - Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosisSriram Chandrasekaran
Center for Biophysics and Computational Biology, Institute for Genomic Biology, Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 107:17845-50. 2010..validating the approach, we used PROM to build a genome-scale integrated metabolic-regulatory model for Mycobacterium tuberculosis, a critically important human pathogen... - Evaluation of the analytical performance of the Xpert MTB/RIF assayRobert Blakemore
Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
J Clin Microbiol 48:2495-501. 2010..range for the new Xpert MTB/RIF assay, a nucleic acid amplification-based diagnostic system that detects Mycobacterium tuberculosis and rifampin (RIF) resistance in under 2 h... - Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconservedIñaki Comas
Medical Research Council, National Institute for Medical Research, London, UK
Nat Genet 42:498-503. 2010b>Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six major lineages of the M... - Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in miceBo Young Jeon
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 76:5173-80. 2008Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective .. - ESX/type VII secretion systems and their role in host-pathogen interactionRoxane Simeone
Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, 25 rue du Dr Roux, 75724 Paris, France
Curr Opin Microbiol 12:4-10. 2009..These two proteins, which form a 1:1 heterodimeric complex, are among the most important proteins of Mycobacterium tuberculosis involved in host-pathogen interaction... - Chemokine IP-10: an adjunct marker for latent tuberculosis infection in childrenJennifer Lighter
Saul Krugman Division of Pediatric Infectious Diseases and Immunology, New York University School of Medicine, New York, New York 10016, USA
Int J Tuberc Lung Dis 13:731-6. 2009Recent reports indicate a role of chemokine inducible protein 10 (IP-10) in Mycobacterium tuberculosis infection substantiated by the detection of elevated levels in plasma and at infection foci in individuals infected with M. tuberculosis... - Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosisDiane Ordway
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
Clin Vaccine Immunol 15:1248-58. 2008..lymph nodes of naïve and vaccinated guinea pigs challenged by low-dose aerosol infection with virulent Mycobacterium tuberculosis. As anticipated, vaccinated guinea pigs controlled the growth of the challenge infection more .. - Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptakeAmanda C Brown
Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
BMC Microbiol 8:78. 2008..In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme .. - Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthaseLuiz Pedro S de Carvalho
Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
Chem Biol 17:323-32. 2010..The Mycobacterium tuberculosis protein Rv1248c was incompletely characterized as a thiamine diphosphate-dependent alpha-ketoglutarate .. - Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteriaSangeeta Tiwari
Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Immunol 10:907-17. 2009..in particular, Irgm1, is essential for macrophage host defense against phagosomal pathogens, including Mycobacterium tuberculosis (Mtb)... - Impact and cost-effectiveness of culture for diagnosis of tuberculosis in HIV-infected Brazilian adultsDavid W Dowdy
Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS ONE 3:e4057. 2008Culture of Mycobacterium tuberculosis currently represents the closest "gold standard" for diagnosis of tuberculosis (TB), but operational data are scant on the impact and cost-effectiveness of TB culture for human .. - Rapid antibiotic susceptibility testing of Mycobacterium tuberculosis: its utility in resource poor settingsA Poojary
Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai--400012, Maharashtra, India
Indian J Med Microbiol 24:268-72. 2006..the rapid colorimetric nitrate reductase based antibiotic susceptibility (CONRAS) test performed on Mycobacterium tuberculosis isolates with the conventional method i.e, the proportion method... - Molecular characterization of rpoB gene mutations in rifampicine-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in BelarusLeonid P Titov
Belarusian Research Institute for Epidemiology and Microbiology, Minsk, Belarus
Biotechnol J 1:1447-52. 2006The aim of this study was to investigate the frequency, location and type of rpoB mutations in Mycobacterium tuberculosis isolated from patients in Belarus. Tuberculosis cases are increasing every year in Belarus... - Detection of multidrug resistance in Mycobacterium tuberculosisJun ichiro Sekiguchi
International Medical Center of Japan, 1 21 1 Toyama, Shinjuku, Tokyo 162 8655, Japan
J Clin Microbiol 45:179-92. 2007We developed a DNA sequencing-based method to detect mutations in the genome of drug-resistant Mycobacterium tuberculosis. Drug resistance in M. tuberculosis is caused by mutations in restricted regions of the genome... - Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in VietnamM Caws
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
J Clin Microbiol 44:2333-7. 2006.... - [Modern diagnosis of tuberculosis]Chantal Truffot-Pernot
Laboratoire de Bacteriologie Hygiene, Centre National de Référence Mycobactéries et Résistance des Mycobactéries aux Antituberculeux, Groupe Hospitalier Pitie Salpetriere, Paris
Presse Med 35:1739-46. 2006..Immunologic tests that measure the interferon gamma produced by sensitized lymphocytes are promising tools for the diagnosis of latent tuberculosis... - Mixed infection and clonal representativeness of a single sputum sample in tuberculosis patients from a penitentiary hospital in GeorgiaIsdore C Shamputa
Prince Leopold Institute of Tropical Medicine, Mycobacteriology Unit, Nationalestraat 155, B 2000 Antwerp, Belgium
Respir Res 7:99. 2006..tuberculosis (TB), TB molecular epidemiology and drug susceptibility testing rely on the analysis of one Mycobacterium tuberculosis isolate from a single sputum sample collected at different disease episodes... - Use of genotype MTBDR assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical strains isolated in ItalyPaolo Miotto
Emerging Bacterial Pathogens, San Raffaele Scientific Institute, Milan, Italy
J Clin Microbiol 44:2485-91. 2006b>Mycobacterium tuberculosis is one of the leading causes of death worldwide, and multidrug-resistant tuberculosis (MDR-TB) is associated with a high case fatality rate... - Rapid phenotypic assay of antimycobacterial susceptibility pattern by direct mycobacteria growth indicator tube and phage amplified biological assay compared to BACTEC 460 TBMaysaa el-Sayed Zaki
Clinical Pathology, Mansoura University, Egypt
Tuberculosis (Edinb) 87:102-8. 2007..404 days. Also FAST-plaque TB-MDR method is accurate for detection of rifampicin resistance after primary culture which can be used as a surrogate marker for presence of MDR strains and the results were available within 10.5-11.5 days... - Molecular characteristics of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian FederationMaxim V Afanas'ev
Research Institute for Physical Chemical Medicine of Ministry of Public Health of Russian Federation, Malaya Pirogovskaya St, 1a, Moscow, Russia
J Antimicrob Chemother 59:1057-64. 2007Three Mycobacterium tuberculosis genetic loci--rpoB and katG genes and the fabG1(mabA)-inhA operon promoter region--were studied to reveal the mutations associated with rifampicin and isoniazid resistance. - Evaluation of the Genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis isolatesCengiz Cavusoglu
Ege University Medical Faculty, Department of Clinical Microbiology, Mycobacteriology Laboratory, 35100 Izmir, Turkey
J Clin Microbiol 44:2338-42. 2006..Germany) was evaluated for rapid detection of rifampin (RIF) and isoniazid (INH) resistance in Turkish Mycobacterium tuberculosis isolates... - Direct detection of Mycobacterium tuberculosis complex DNA and rifampin resistance in clinical specimens from tuberculosis patients by line probe assayHamidou Traore
Mycobacteriology Unit, Microbiology Department, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
J Clin Microbiol 44:4384-8. 2006..To assess the utility of this test for detecting Mycobacterium tuberculosis complex DNA and rifampin (RMP) resistance, 420 sputum samples comprising specimens from untreated (n=160).. - Use of smear-positive samples to assess the PCR-based genotype MTBDR assay for rapid, direct detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampinAkos Somoskovi
Wadsworth Center, New York State Department of Health, P.O. Box 509, Albany, NY 12201-0509, USA
J Clin Microbiol 44:4459-63. 2006..Historically, the identification and testing of the susceptibility of Mycobacterium tuberculosis complex (MTBC) strains takes weeks to complete... - Molecular characterization of mutation associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis isolatesSanjay Singh Negi
Microbiology Division, National Institute of Communicable Diseases, Delhi 110 054, India
Indian J Exp Biol 44:547-53. 2006..B), responsible for isoniazid and rifampicin drug resistance were determined in the clinical isolates of Mycobacterium tuberculosis by PCR-RFLP, Line probe assay and DNA sequencing... - Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USAHongling Guo
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA
J Med Microbiol 55:1527-31. 2006..strains with no katG or inhA mutation, this study characterized a panel of 28 clinical isolates of Mycobacterium tuberculosis and five mutants derived from H37Rv resistant to INH... - Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growthTawanda Gumbo
Emerging Infections and Host Defenses Section, Ordway Research Institute, Albany, NY, USA
J Infect Dis 195:194-201. 2007..of isoniazid's early bactericidal activity during the initial phase of antituberculosis therapy is due to the depletion of Mycobacterium tuberculosis in the exponential phase of growth. We examined the veracity of this cornerstone belief. - Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimensDoris Hillemann
Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Parkallee 18, D 23845 Borstel, Germany
J Clin Microbiol 45:2635-40. 2007..sputum specimens for its ability to detect rifampin (RMP) and isoniazid (INH) resistance in Mycobacterium tuberculosis complex (MTBC) strains... - Evaluation of methods for rapid detection of resistance to isoniazid and rifampin in Mycobacterium tuberculosis isolates collected in the CaribbeanPatrick Eberechi Akpaka
Department of Para Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
J Clin Microbiol 46:3426-8. 2008The rapid identification of drug-resistant strains of Mycobacterium tuberculosis is crucial for the timely initiation of appropriate antituberculosis therapy... - Genotypic analysis of isoniazid and rifampin resistance in drug-resistant clinical Mycobacterium tuberculosis complex isolates in southern TurkeyGonul Aslan
Department of Medical Microbiology, Faculty of Medicine, University of Mersin, Mersin, Turkey
Jpn J Infect Dis 61:255-60. 2008..katG, inhA, and rpoB gene mutations underlying isoniazid (INH) and rifampin (RMP) resistance in clinical Mycobacterium tuberculosis complex isolates... - Paediatric tuberculosisSandra M Newton
Department of Paediatrics, Imperial College London, London, UK
Lancet Infect Dis 8:498-510. 2008..Advances in our understanding of tuberculosis in children would provide insights and opportunities to enhance efforts to control this disease... - Rifampin resistance, Beijing-W clade-single nucleotide polymorphism cluster group 2 phylogeny, and the Rv2629 191-C allele in Mycobacterium tuberculosis strainsSoumitesh Chakravorty
Division of Infectious Disease, Department of Medicine, and the Ruy V Lourenço Center for the Study of Emerging and Reemerging Pathogens, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
J Clin Microbiol 46:2555-60. 2008..1% of rifampin-resistant and 0% of rifampin-susceptible clinical Mycobacterium tuberculosis isolates and that overexpression of the Rv2629 191C allele in Mycobacterium smegmatis produced an .. - Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in JapanChiyoji Abe
Fukushima Laboratory, Nippon Becton Dickinson Diagnostic Systems, Tsuchifune, Fukushima 960 2152, Japan
J Clin Microbiol 46:2263-8. 2008..BACTEC MGIT 960 antimicrobial susceptibility testing system (MGIT 960 AST) by using 1,112 isolates of Mycobacterium tuberculosis. When the results of MGIT 960 AST were compared with that of the proportion method using Ogawa medium (.. - Detection of mutation in isoniazid-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in BelarusS Z Bostanabad
Belarusian Research Institute for Epidemiology and Microbiology, Filimonova 23, Minsk, Belarus
Indian J Med Microbiol 26:143-7. 2008The aim of this study was to investigate the frequency, location and type of katG mutations in Mycobacterium tuberculosis strains isolated from patients in Belarus... - Evaluation of the GenoCard as a tool for transport and storage of samples for tuberculosis molecular drug susceptibility testingPaolo Miotto
Emerging Bacterial Pathogens, San Raffaele Scientific Institute, Milan, Italy
New Microbiol 31:147-50. 2008..tuberculosis strains is essential to control tuberculosis. The paper-based transport device GenoCard enables the safe shipment of inactivated biological material and strains to be used for molecular detection of drug resistance... - Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy responseJoel Fleury Djoba Siawaya
Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, Western Cape, 7505 South Africa
J Infect 56:340-7. 2008..Twenty HIV-uninfected tuberculosis patients with BACTEC culture positivity for Mycobacterium tuberculosis at diagnosis and treated with directly observed short course anti-tuberculosis chemotherapy and 13 .. - Molecular characterisation of isoniazid-resistant Mycobacterium tuberculosis isolated from new cases in Lagunes region (Côte d'Ivoire)Mireille Dosso
Int J Antimicrob Agents 31:498-500. 2008 - Secular trends in susceptibility patterns of Mycobacterium tuberculosis isolates in Kuwait, 1996-2005E Mokaddas
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
Int J Tuberc Lung Dis 12:319-25. 2008To determine the incidence and trends of drug resistance among all Mycobacterium tuberculosis strains isolated during a 10-year period in Kuwait. - Treatment of isoniazid-resistant pulmonary tuberculosisYee Hyung Kim
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
BMC Infect Dis 8:6. 2008Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-.. - katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis isolates from Belarusian patientsSaeed Zaker Bostanabad
Belarusian State Medical University, and Belarusian Research Institute for Epidemiology and Microbiology, Minsk, Belarus
Tuberk Toraks 55:231-7. 2007The aim of this study was to investigate the frequency, location and type of katG mutations in Mycobacterium tuberculosis strains isolated from patients in Belarus... - Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from ChinaRuiru Shi
Mycobacterial Reference Center, The Research Institute of Tuberculosis, 3 1 24 Matsuyama, Kiyose, Tokyo, Japan
Antimicrob Agents Chemother 51:4515-7. 2007Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin... - Characterization of Tunisian Mycobacterium tuberculosis rifampin-resistant clinical isolatesAlya Soudani
Bacteriology Laboratory, Rabta University Hospital, Tunis, Tunisia
J Clin Microbiol 45:3095-7. 2007Analysis of the gene encoding the beta-subunit of Mycobacterium tuberculosis RNA polymerase (rpoB) has demonstrated a small region that harbors the mutations most frequently associated with rifampin resistance... - Facing the crisis: improving the diagnosis of tuberculosis in the HIV eraMark D Perkins
Foundation for Innovative New Diagnostics, Geneva, Switzerland
J Infect Dis 196:S15-27. 2007..In this article, we will define the need for better TB tests and describe technologies being developed to meet that need... - M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern TanzaniaGibson S Kibiki
Department of Internal Medicine, Endoscopy Unit, Kilimanjaro Christian Medical Centre, Tumaini University, Moshi, Tanzania
BMC Microbiol 7:51. 2007..TB positive culture, BAL fluid or sputum samples from 130 patients were collected and genotyped. The spoligotypes were correlated with anti-tuberculous drug susceptibility in HIV-infected and non-HIV patients from Tanzania... - TuberculosisThomas R Frieden
New York City Department of Health and Mental Hygiene, New York, NY 10013, USA
Lancet 362:887-99. 2003..Definitive diagnosis of tuberculosis remains based on culture for Mycobacterium tuberculosis, but rapid diagnosis of infectious tuberculosis by simple sputum smear for acid-fast bacilli remains an .. - Molecular analysis of isoniazid, rifampin and streptomycin resistance in Mycobacterium tuberculosis isolates from patients with tuberculosis in Düzce, TurkeyC Elif Ozturk
Department of Microbiology, Abant Izzet Baysal University, Duzce School of Medicine, Duzce, Turkey
Jpn J Infect Dis 58:309-12. 2005..genes (katG, inhA, rpoB, rpsL) in isoniazid (INH)-, rifampin (RIF)- and streptomycin (SM)-resistant Mycobacterium tuberculosis strains obtained from subjects in Duzce, Turkey... - [Mycobacterium tuberculosis resistance to antitubercular agents in Antananarivo in 2000]O Ratsirahonana
, Institut Pasteur de Madagascar, BP 1274-101 Antananarivo-Madagascar
Arch Inst Pasteur Madagascar 68:44-7. 2002..1% for primary MDR and 4% for acquired MDR. These results show that ten years after the new NTP implementation, only a few MDR strains are circulating in Antananarivo, which suggests that NTP has been effective... - Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in LithuaniaDaiva Bakonyte
Laboratory of Immunology, Institute of Biotechnology, Vilnius 2028, Lithuania
Antimicrob Agents Chemother 47:2009-11. 2003Mutations at codon 315 of the katG gene were detected in 312 of 364 (85.7%) isoniazid-resistant Mycobacterium tuberculosis isolates. Seven of 52 (13.5%) isoniazid-resistant isolates with the wild-type Ser315 codon and 10 of 52 (19... - Susceptibilities of Mycobacterium tuberculosis to isoniazid and rifampin on blood agarAhmet Yilmaz Coban
Ondokuz Mayis University, Medical School, Department of Microbiology and Clinical Microbiology, 55139 Samsun, Turkey
J Clin Microbiol 43:1930-1. 2005..blood agar was used instead of 7H10 agar for the susceptibility testing of 34 clinical isolates of Mycobacterium tuberculosis to isoniazid (INH) and rifampin (RIF) in accordance with the NCCLS... - Drug-sensitivity profile of clinical Mycobacterium tuberculosis isolates--a retrospective study from a chest-disease institute in IndiaT Dam
Department of Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007, India
J Med Microbiol 54:269-71. 2005..5 %) were susceptible to all four first-line antituberculosis drugs. This study reports low resistance to fluoroquinolones among the strains present in these patients... - Development of acquired drug resistance in recurrent tuberculosis patients with various previous treatment outcomesT Yoshiyama
Epidemiology Division, Research Institute of Tuberculosis, Kiyose, Tokyo, Japan
Int J Tuberc Lung Dis 8:31-8. 2004..Chiang Rai province, Northern Thailand...
Research Grants
- Mode of Action of Thiorcarlide in Mycobacterium TuberculosisMary Jackson; Fiscal Year: 2010Thiocarlide (THC), a thiourea, inhibits the synthesis of mycolic acids and fatty acids in Mycobacterium tuberculosis (M. tb)...
- Susceptibility of Mycobacterium tuberculosis clinical isolates to moxifloxacinHANAA EL SAHLI; Fiscal Year: 2007..data suggest that there is cross resistance among various quinolones and that quinolone-resistance in Mycobacterium tuberculosis (MTB) isolates can affect the efficacy of the treatment...
- Phenotype MicroArray Analysis of Fastidious PathogensBarry Bochner; Fiscal Year: 2007b>Mycobacterium tuberculosis and other Mycobacterium species are major pathogens around the world...
- M. tuberculosis survival in MacrophagesRichard Friedman; Fiscal Year: 2003..The infection of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, intracellular survival, and multiplication...
- Screening Complete TB Proteome for Protective AntigensAlan Greener; Fiscal Year: 2007This project will complete the identification and immunogenicity analyses of all proteins encoded by the Mycobacterium tuberculosis (Mtb) genome, yielding a pool of protective antigens that will immediately enter development as subunit ..
- STRUCTURE-BASED TUBERCULOSIS DRUG DESIGN TARGETED AT ACYL-COA CARBOXYLASEShiou Chuan Tsai; Fiscal Year: 2010..Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Mycobacterium tuberculosis, the pathogen of tuberculosis (TB), has a cell envelope with chemically complex lipids that are closely ..
- PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGESSteven Greenberg; Fiscal Year: 2000..of the lung's host defense against a variety of pathogenic organisms, including Streptococcal pneumonia, Mycobacterium tuberculosis, and Pneumocystis carinii...
- DISSEMINATED TUBERCULOSIS IN HIV INFECTIONC von Reyn; Fiscal Year: 2004Disseminated infection (mycobacteremia) with Mycobacterium tuberculosis (dMTB) has been documented by our group in 10-25 percent of patients with HIV infection in Africa using lysis- centrifugation blood cultures...
- The effect of pncA expression and POA efflux rate in the level of PZA-resistanceMirko J Zimic; Fiscal Year: 2010..It is still the most effective drug against the latent stage of Mycobacterium tuberculosis but its mechanism of resistance is not completely understood yet...
- Design of antituberculosis agents that target siderophore biosynthesisCourtney C Aldrich; Fiscal Year: 2010Tuberculosis (TB) caused by the slow growing bacillus Mycobacterium tuberculosis (Mtb) is the leading cause of infectious disease mortality in the world by a bacterial pathogen...
- DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDSKurt Krause; Fiscal Year: 2003..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
- MAS-PCR Rapid Screening Test for Multidrug-Resistant Tuberculosis (MDR-TB)Angkana Chaiprasert; Fiscal Year: 2010Resistance of Mycobacterium tuberculosis to drugs used for treatment of TB infection has become a significant problem, and the existence of multidrug-resistant tuberculosis (MDR-TB) is increasing throughout the world...
- Deciphering of the Toxin-Antitoxin Systems in E. coliMasayori Inouye; Fiscal Year: 2010..Surprisingly, many bacteria, particularly human pathogens such as Mycobacterium tuberculosis contain a large number of independent toxin genes on their genomes...
- Deciphering of the Toxin-Antitoxin Systems in E. coliMasayori Inouye; Fiscal Year: 2010..Surprisingly, many bacteria, particularly human pathogens such as Mycobacterium tuberculosis contain a large number of independent toxin genes on their genomes...
- M. tuberculosis Genes Regulating Persistent InfectionThomas Zahrt; Fiscal Year: 2007b>Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB) and is responsible for more than 1.7 million deaths and 8 million new infections annually...
- Mycobacterium tuberculosis carbon metabolism in vivoJohn McKinney; Fiscal Year: 2007..and 2 (ICL2), which catalyze the first unique reaction in the glyoxylate cycle, are jointly required for Mycobacterium tuberculosis (MTB) growth, survival, and virulence in vivo...
- Regulation of host response genes in pathogenesis of TBJesse Roman; Fiscal Year: 2005DESCRIPTION (provided by applicant) Mycobacterium tuberculosis (Mtb) is the leading infectious cause of death worldwide...