mycobacterium tuberculosis

Summary

Summary: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.

Top Publications

  1. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
  2. ncbi Genes required for mycobacterial growth defined by high density mutagenesis
    Christopher M Sassetti
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 48:77-84. 2003
  3. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
  4. ncbi Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    S T Cole
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Nature 393:537-44. 1998
  5. ncbi Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    Maximiliano G Gutierrez
    Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza 5500, Argentina
    Cell 119:753-66. 2004
  6. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
  7. pmc Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 43:482-6. 2011
  8. pmc Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
    Iñaki Comas
    Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 42:498-503. 2010
  9. pmc Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    Lancet 377:1495-505. 2011
  10. pmc Disseminated tuberculosis in interferon gamma gene-disrupted mice
    A M Cooper
    Department of Microbiology, Colorado State University, Fort Collins 80523
    J Exp Med 178:2243-7. 1993

Detail Information

Publications268 found, 100 shown here

  1. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    ..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
  2. ncbi Genes required for mycobacterial growth defined by high density mutagenesis
    Christopher M Sassetti
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 48:77-84. 2003
    ..site hybridization (TraSH) to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth...
  3. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to ..
  4. ncbi Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    S T Cole
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Nature 393:537-44. 1998
    ..The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this ..
  5. ncbi Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    Maximiliano G Gutierrez
    Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza 5500, Argentina
    Cell 119:753-66. 2004
    b>Mycobacterium tuberculosis is an intracellular pathogen persisting within phagosomes through interference with phagolysosome biogenesis...
  6. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
    Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment...
  7. pmc Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 43:482-6. 2011
    ..Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains...
  8. pmc Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
    Iñaki Comas
    Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 42:498-503. 2010
    b>Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six major lineages of the M...
  9. pmc Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    Lancet 377:1495-505. 2011
    ..We aimed to assess operational feasibility, accuracy, and effectiveness of implementation in such settings...
  10. pmc Disseminated tuberculosis in interferon gamma gene-disrupted mice
    A M Cooper
    Department of Microbiology, Colorado State University, Fort Collins 80523
    J Exp Med 178:2243-7. 1993
    The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines...
  11. ncbi The population dynamics and control of tuberculosis
    Christopher Dye
    World Health Organization, CH1211 Geneva 27, Switzerland
    Science 328:856-61. 2010
    ..Here we review the changing relationship between the causative agent, Mycobacterium tuberculosis, and its human host and examine a range of factors that could explain the persistence of TB...
  12. ncbi The challenge of new drug discovery for tuberculosis
    Anil Koul
    Department of Antimicrobial Research, Janssen Research and Development, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Nature 469:483-90. 2011
    Tuberculosis (TB) is more prevalent in the world today than at any other time in human history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse strategies to survive in a variety of host lesions and to evade ..
  13. ncbi Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection - United States, 2010
    Gerald H Mazurek
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-25. 2010
    ..Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR;54[No. RR-15]:49-55)...
  14. pmc An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    J L Flynn
    Howard Hughes Medical Institute, Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Exp Med 178:2249-54. 1993
    ..Upon infection with Mycobacterium tuberculosis, although they develop granulomas, gko mice fail to produce reactive nitrogen intermediates and are ..
  15. pmc High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography
    Ruth Hershberg
    Department of Biology, Stanford University, Stanford, California, USA
    PLoS Biol 6:e311. 2008
    b>Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds...
  16. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
    b>Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations...
  17. ncbi Tuberculosis
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Lancet 378:57-72. 2011
    ....
  18. ncbi Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
    R Diel
    Dept of Pneumology, Medical School Hanover, Hanover, Germany
    Eur Respir J 37:88-99. 2011
    ..TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI)...
  19. ncbi Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
    Jennifer L Gardy
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    N Engl J Med 364:730-9. 2011
    ..Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution...
  20. ncbi Cell-mediated immune responses in tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:393-422. 2009
    ..Upon aerosol infection with Mycobacterium tuberculosis (Mtb), the acquired cellular immune response is slow to be induced and to be expressed within the lung...
  21. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..adopted in combination with spoligotyping as the basis for large-scale, high-throughput genotyping of Mycobacterium tuberculosis. However, even the combination of these two methods is still less discriminatory than IS6110 ..
  22. pmc Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Med 8:e1001067. 2011
    ..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown...
  23. ncbi Immunological biomarkers of tuberculosis
    Gerhard Walzl
    Immunology Research Group, NRF DST Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa
    Nat Rev Immunol 11:343-54. 2011
    ..To date, the detection of Mycobacterium tuberculosis or its products has not been able to adequately address these needs...
  24. ncbi Prokaryotic toxin-antitoxin stress response loci
    Kenn Gerdes
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    Nat Rev Microbiol 3:371-82. 2005
    ..For example, Mycobacterium tuberculosis has 38 chromosomal toxin-antitoxin loci, including 3 relBE and 9 mazEF loci...
  25. ncbi Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 184:132-40. 2011
    ..Xpert MTB/RIF is a novel automated molecular diagnostic recently endorsed by the World Health Organization. However, performance-related data from high HIV prevalence settings are limited...
  26. pmc The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
    Clifton E Barry
    Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 7:845-55. 2009
    ..biology of latent tuberculosis as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide ..
  27. pmc High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1002251. 2011
    ..a new method of global phenotypic profiling to directly define the genes required for the growth of Mycobacterium tuberculosis. A combination of high-density mutagenesis and deep-sequencing was used to characterize the composition ..
  28. pmc Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
    C Nathan
    Department of Microbiology and Immunology and Department of Medicine, Weill Cornell Medical College and Program in Immunology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:8841-8. 2000
    ..Genetic and biochemical approaches have identified candidates for RNI-resistance genes in Mycobacterium tuberculosis and other pathogens.
  29. pmc Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence
    Pascale Peyron
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, Toulouse, France
    PLoS Pathog 4:e1000204. 2008
    Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis and host cells within granulomas...
  30. ncbi A delicate dance: host response to mycobacteria
    Kassidy K Huynh
    Department of Microbial Pathogenesis, Genentech, Inc, South San Francisco, CA 94080, USA
    Curr Opin Immunol 23:464-72. 2011
    b>Mycobacterium tuberculosis is an enormously successful human pathogen that can infect its host for decades without causing clinical disease, only to reactivate when host immunity is compromised...
  31. pmc Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
    Bisweswar Nandi
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:2251-62. 2011
    Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response...
  32. pmc Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis
    Patricia J Campbell
    Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Bldg 17, Room 4029, M S F08, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 55:2032-41. 2011
    ..A total of 314 clinical Mycobacterium tuberculosis complex isolates representing a variety of antibiotic resistance patterns, genotypes, and geographical ..
  33. ncbi SITVITWEB--a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology
    Christophe Demay
    WHO Supranational TB Reference Laboratory, Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Abymes Cedex, Guadeloupe
    Infect Genet Evol 12:755-66. 2012
    Among various genotyping methods to study Mycobacterium tuberculosis complex (MTC) genotypic polymorphism, spoligotyping and mycobacterial interspersed repetitive units-variable number of DNA tandem repeats (MIRU-VNTRs) have recently ..
  34. ncbi HIV infection and multidrug-resistant tuberculosis: the perfect storm
    Charles D Wells
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S86-107. 2007
    ..The global human immunodeficiency virus (HIV) infection epidemic has caused explosive increases in TB incidence and may be contributing to increases in MDR-TB prevalence...
  35. pmc Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies
    Iñaki Comas
    Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
    PLoS ONE 4:e7815. 2009
    ..Using the Mycobacterium tuberculosis complex (MTBC) as a model, we evaluated the phylogenetic accuracy of CRISPR- and VNTR-based genotyping, ..
  36. pmc Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
    Michael Strong
    Howard Hughes Medical Institute, UCLA Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:8060-5. 2006
    ..by the structural determination of a previously unknown complex between a PE and PPE protein from the Mycobacterium tuberculosis genome, members of protein families that constitute approximately 10% of the coding capacity of this ..
  37. pmc Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
    Iñaki Comas
    Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 44:106-10. 2012
    ..Our findings support a role for compensatory evolution in the global epidemics of MDR TB...
  38. pmc HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis?
    Collin R Diedrich
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 79:1407-17. 2011
    Human immunodeficiency virus type 1 (HIV) and Mycobacterium tuberculosis have become intertwined over the past few decades in a "syndemic" that exacerbates the morbidity and mortality associated with each pathogen alone...
  39. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
    ..Our direct observations provide insight into how pathogenic mycobacteria exploit the granuloma during the innate immune phase for local expansion and systemic dissemination...
  40. ncbi Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease
    Alexandre Harari
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Nat Med 17:372-6. 2011
    Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and laboratory challenge...
  41. pmc Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production
    Caroline Colijn
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 5:e1000489. 2009
    ..We applied E-Flux to Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB)...
  42. pmc Toll-like receptor 4 is a sensor for autophagy associated with innate immunity
    Yi Xu
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 27:135-44. 2007
    ..We further showed that LPS-induced autophagy could enhance mycobacterial colocalization with the autophagosomes. This study links two ancient processes, autophagy and innate immunity, together through a shared signaling pathway...
  43. pmc Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology
    Danica Helb
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry, New Jersey, Newark, New Jersey 07103, USA
    J Clin Microbiol 48:229-37. 2010
    Current nucleic acid amplification methods to detect Mycobacterium tuberculosis are complex, labor-intensive, and technically challenging...
  44. ncbi Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, University of Palermo, Palermo, Italy
    Eur J Immunol 40:2211-20. 2010
    Th1 CD4(+) T cells and their derived cytokines are crucial for protection against Mycobacterium tuberculosis. Using multiparametric flow cytometry, we have evaluated the distribution of seven distinct functional states (IFN-γ/IL-2/TNF-α ..
  45. pmc The enduring hypoxic response of Mycobacterium tuberculosis
    Tige R Rustad
    Seattle Biomedical Research Institute, Seattle, Washington, USA
    PLoS ONE 3:e1502. 2008
    ..Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by the two-component response regulator DosR. The initial hypoxic response is completely blocked in a dosR deletion mutant...
  46. ncbi Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis
    M Sester
    Dept of Transplant and Infection Immunology, Saarland University, Homburg, Germany
    Eur Respir J 37:100-11. 2011
    Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent infection with Mycobacterium tuberculosis in many countries...
  47. pmc Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis
    Sriram Chandrasekaran
    Center for Biophysics and Computational Biology, Institute for Genomic Biology, Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 107:17845-50. 2010
    ..validating the approach, we used PROM to build a genome-scale integrated metabolic-regulatory model for Mycobacterium tuberculosis, a critically important human pathogen...
  48. pmc Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:807-19. 2011
    ..of effector cytokines by CD4+ T cells within hepatic granulomas triggered by Bacille Calmette-Guérin or Mycobacterium tuberculosis. At steady-state, only small fractions of mycobacteria-specific T cells showed antigen-induced migration ..
  49. pmc Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Infect Dis 204:S1159-67. 2011
    ..Further development and implementation of these tools is vital to permit rapid and effective screening for TB in ART services, which is an essential component of patient care...
  50. pmc Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chem Biol 19:218-27. 2012
    To understand the adaptation of Mycobacterium tuberculosis to the intracellular environment, we used comprehensive metabolite profiling to identify the biochemical pathways utilized during growth on cholesterol, a critical carbon source ..
  51. pmc Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death
    Roxane Simeone
    Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Paris, France
    PLoS Pathog 8:e1002507. 2012
    Survival within macrophages is a central feature of Mycobacterium tuberculosis pathogenesis...
  52. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family...
  53. pmc "Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 6:e24737. 2011
    b>Mycobacterium tuberculosis has a global population structure consisting of six main phylogenetic lineages associated with specific geographic regions and human populations. One particular M...
  54. pmc Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis
    Kristine B Arnvig
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 7:e1002342. 2011
    RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5' and 3' untranslated regions, antisense transcripts, and intergenic small RNA (..
  55. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005
    ..we analyzed the resistance of TLR9(-/-) as well as TLR2/9 double knockout mice to aerosol infection with Mycobacterium tuberculosis. Infected TLR9(-/-) but not TLR2(-/-) mice displayed defective mycobacteria-induced interleukin (IL)-..
  56. ncbi Mechanisms of drug resistance in Mycobacterium tuberculosis
    Y Zhang
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Int J Tuberc Lung Dis 13:1320-30. 2009
    ..Drug resistance in Mycobacterium tuberculosis arises from spontaneous chromosomal mutations at low frequency...
  57. pmc Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
    Clifford V Harding
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 7288, USA
    Nat Rev Microbiol 8:296-307. 2010
    b>Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as macrophages and dendritic cells...
  58. ncbi Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 164:2016-20. 2000
    Human alveolar macrophages (AMphi) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro...
  59. ncbi ESX/type VII secretion systems and their role in host-pathogen interaction
    Roxane Simeone
    Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, 25 rue du Dr Roux, 75724 Paris, France
    Curr Opin Microbiol 12:4-10. 2009
    ..These two proteins, which form a 1:1 heterodimeric complex, are among the most important proteins of Mycobacterium tuberculosis involved in host-pathogen interaction...
  60. pmc Mycobacterial survival strategies in the phagosome: defence against host stresses
    Sabine Ehrt
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Microbiol 11:1170-8. 2009
    Infections with Mycobacterium tuberculosis remain a major cause of disease and death in humans. Among the factors that contribute to M...
  61. pmc Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis
    S M Behar
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Mucosal Immunol 4:279-87. 2011
    Two different forms of death are commonly observed when Mycobacterium tuberculosis (Mtb)-infected macrophages die: (i) necrosis, a death modality defined by cell lysis and (ii) apoptosis, a form of death that maintains an intact plasma ..
  62. ncbi Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    John D MacMicking
    Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 302:654-9. 2003
    ..immunity to tuberculosis by activating infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (Mtb)...
  63. ncbi Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 6:231-43. 2009
    ..D3-mediated innate immunity have been shown to confer protection against infection with intracellular Mycobacterium tuberculosis. Here, we show that these two antimycobacterial defenses are physiologically linked via a regulatory ..
  64. ncbi Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran
    Ali Akbar Velayati
    Mycobacteriology Research Centre, the National Research Institute of Tuberculosis and Lung Disease, World Health Organization Collaborating Centre, Shahid Beheshti University, Darabad, Tehran, Iran
    Chest 136:420-5. 2009
    ..The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB)...
  65. pmc Role of innate cytokines in mycobacterial infection
    A M Cooper
    Trudeau Institute, Saranac Lake, New York, USA
    Mucosal Immunol 4:252-60. 2011
    ..In the case of Mycobacterium tuberculosis, the lung is a critical site for this interaction...
  66. pmc Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages
    Paolo S Manzanillo
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 11:469-80. 2012
    ..pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M...
  67. pmc Initiation and regulation of T-cell responses in tuberculosis
    K B Urdahl
    Seattle Biomedical Research Institute, Seattle, Washington, USA
    Mucosal Immunol 4:288-93. 2011
    ..Among the characteristics of adaptive immune responses to Mycobacterium tuberculosis is a delay in the onset of detectable T-cell responses, in both humans and experimental animals...
  68. pmc Innate immune recognition of Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    Clin Dev Immunol 2011:405310. 2011
    Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense against M...
  69. pmc Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction
    Arun K Mishra
    School of Biosciences, University of Birmingham, Edgbaston, UK
    FEMS Microbiol Rev 35:1126-57. 2011
    Approximately one third of the world's population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis...
  70. pmc Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair
    Maziar Divangahi
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 10:899-906. 2009
    Induction of macrophage necrosis is a strategy used by virulent Mycobacterium tuberculosis (Mtb) to avoid innate host defense...
  71. pmc Understanding latent tuberculosis: a moving target
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Immunol 185:15-22. 2010
    Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection...
  72. pmc Toll-like receptors control autophagy
    Monica A Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
    EMBO J 27:1110-21. 2008
    ....
  73. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection...
  74. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    Boosting bacillus Calmette-Guérin (BCG)-primed mice with a recombinant adenovirus expressing Mycobacterium tuberculosis Ag 85A by different administration routes has very different effects on protection against aerosol challenge with M...
  75. pmc Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution
    Holly R Ramage
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000767. 2009
    ..genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M...
  76. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
    ..We hypothesized that some strains of Mycobacterium tuberculosis (M...
  77. pmc Tuberculosis: what we don't know can, and does, hurt us
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Science 328:852-6. 2010
    b>Mycobacterium tuberculosis has a penetrance of its host population that would be the envy of most human pathogens...
  78. ncbi Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence
    Huixian Gan
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 9:1189-97. 2008
    Macrophages infected with attenuated Mycobacterium tuberculosis strain H37Ra become apoptotic, which limits bacterial replication and facilitates antigen presentation...
  79. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
    Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens...
  80. ncbi Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
    Anil Koul
    Departments of Antimicrobial Research and Functional Genomics, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Biol Chem 283:25273-80. 2008
    An estimated one-third of the world population is latently infected with Mycobacterium tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-tuberculosis drugs, such as isoniazid...
  81. pmc Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv
    HuaJun Zheng
    State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 3:e2375. 2008
    Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M...
  82. ncbi An antimicrobial activity of cytolytic T cells mediated by granulysin
    S Stenger
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 282:121-5. 1998
    ..Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the ..
  83. pmc Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 51:823-9. 2010
    ..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa...
  84. pmc Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals
    Clare R Sander
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 179:724-33. 2009
    ..An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care...
  85. pmc Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
    Sladjana Prisic
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7521-6. 2010
    The Mycobacterium tuberculosis genome encodes 11 serine/threonine protein kinases (STPKs) that are structurally related to eukaryotic kinases...
  86. pmc Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis
    Shahin Shafiani
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 207:1409-20. 2010
    The ability of the adaptive immune system to restrict Mycobacterium tuberculosis (Mtb) is impeded by activated Foxp3(+) regulatory T (T reg) cells. The importance of pathogen-specific T reg cells in this process has not been addressed...
  87. ncbi Fluoroquinolones, tuberculosis, and resistance
    Amy Sarah Ginsburg
    Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet Infect Dis 3:432-42. 2003
    ..However, there is concern about the development of fluoroquinolone resistance in Mycobacterium tuberculosis, particularly when administered as monotherapy or as the only active agent in a failing multidrug ..
  88. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..Mannose-expressing Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) induced the recruitment of effector proteins to the DC-..
  89. pmc Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    Infect Immun 77:4631-42. 2009
    We previously described that low-dose Mycobacterium tuberculosis infection in cynomolgus macaques results in a spectrum of disease similar to that of human infection: primary disease, latent infection, and reactivation tuberculosis (S. V...
  90. pmc Why is long-term therapy required to cure tuberculosis?
    Lynn E Connolly
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Med 4:e120. 2007
  91. pmc The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
    Peter B Kang
    Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 202:987-99. 2005
    b>Mycobacterium tuberculosis (M.tb) survives in macrophages in part by limiting phagosome-lysosome (P-L) fusion. M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation...
  92. pmc The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    Marcela Parra
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 72:6799-805. 2004
    The heparin-binding hemagglutinin (HBHA) of Mycobacterium tuberculosis is a surface-expressed adhesin that can affect binding to host cells via a unique, methylated, carboxyl-terminal, lysine-, alanine-, and proline-rich repeat region...
  93. ncbi Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy
    Gillian L Dean
    St Thomas Hospital, London, UK
    AIDS 16:75-83. 2002
    ..To assess the risks and benefits of administering highly active antiretroviral therapy (HAART) during the treatment of tuberculosis (TB) in HIV-infected patients...
  94. pmc TB database: an integrated platform for tuberculosis research
    T B K Reddy
    Department of Biochemistry, Stanford University, CA 94305, USA
    Nucleic Acids Res 37:D499-508. 2009
    ..The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M...
  95. pmc Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta
    C Manca
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:5752-7. 2001
    ..disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates...
  96. pmc Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
    Amanda C Brown
    Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    BMC Microbiol 8:78. 2008
    ..In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme ..
  97. pmc Evaluation of the analytical performance of the Xpert MTB/RIF assay
    Robert Blakemore
    Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Clin Microbiol 48:2495-501. 2010
    ..range for the new Xpert MTB/RIF assay, a nucleic acid amplification-based diagnostic system that detects Mycobacterium tuberculosis and rifampin (RIF) resistance in under 2 h...
  98. ncbi Mycobacterium tuberculosis and the environment within the phagosome
    Kyle Rohde
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Immunol Rev 219:37-54. 2007
    ..b>Mycobacterium tuberculosis infects macrophages through arresting the normal maturation process of the phagosome, retaining its ..
  99. pmc Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:105-15. 2008
    The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed compared with that of other infections or immunization, and allows the bacterial population in the lungs to expand markedly during the preimmune phase of ..
  100. pmc The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000296. 2010
    ..We conducted limited autopsies on young adults dying in a single public hospital in the province of KwaZulu-Natal between October 2008 and August 2009 in order to estimate the magnitude of deaths attributable to tuberculosis...
  101. pmc CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:1598-607. 2011
    Although CD4 T cells are required for host resistance to Mycobacterium tuberculosis, they may also contribute to pathology. In this study, we examine the role of the inhibitory receptor PD-1 and its ligand PD-L1 during M...

Research Grants76

  1. M. tuberculosis survival in Macrophages
    Richard Friedman; Fiscal Year: 2003
    ..The infection of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, intracellular survival, and multiplication...
  2. STRUCTURE-BASED TUBERCULOSIS DRUG DESIGN TARGETED AT ACYL-COA CARBOXYLASE
    Shiou Chuan Tsai; Fiscal Year: 2010
    ..Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Mycobacterium tuberculosis, the pathogen of tuberculosis (TB), has a cell envelope with chemically complex lipids that are closely ..
  3. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..Many have complex mechanisms to rapidly generate diversity in critical antigens. Mycobacterium tuberculosis chronically infects one third of the worlds'population and similarly must avoid clearance by the ..
  4. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for about 40 percent of the total deaths with an even greater cost ..
  5. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    This project will complete the identification and immunogenicity analyses of all proteins encoded by the Mycobacterium tuberculosis (Mtb) genome, yielding a pool of protective antigens that will immediately enter development as subunit ..
  6. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..A key discovery was that the adaptive immune response to Mycobacterium tuberculosis (Mtb) is delayed in diabetic mice during the period of logarithmic bacillary replication...
  7. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..Myx exhibits potent antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and ..
  8. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb) latently infects one third of the world's population and remains a leading cause of death from a single bacterial infection worldwide...
  9. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..Eduardo Groisman, WU, and Dr. Yixin Shi, Univ. Arizona-Tempe);(6) Mycobacterium tuberculosis cell wall lipid molecular species and cellular mechanisms of destructive host tissue reactions in a ..
  10. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tuberculosis, caused by Mycobacterium tuberculosis, continues to be a public health problem in many countries including the United States because of its prevalence in HIV-infected patients and also ..
  11. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..agents, which are in great need due to the alarming rise of multi- and extensively-drug resistant Mycobacterium tuberculosis (MDR-/XDR-TB)...
  12. Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Dana Boyd; Fiscal Year: 2013
    ..Many other bacteria, including Mycobacterium tuberculosis (Mtb), appear to use a homologue of human vitamin K epoxide reductase, VKOR, for disulfide bond ..
  13. Crystalline Endolysin Treatment for Tuberculosis in TB/HIV co-infected patients
    BHAMI C SHENOY; Fiscal Year: 2012
    ..end of 2008, approximately 2 billion people one-third of the world's population is infected with Mycobacterium tuberculosis (MTb), the etiologic agent of TB...
  14. Expression signatures of TB-specific memory responses within the human lung
    Richard F Silver; Fiscal Year: 2013
    ..b>Mycobacterium tuberculosis (Mtb), the organism that causes TB, is a respiratory pathogen spread via inhalation of infectious ..
  15. TOLLIP and Tuberculosis Immunopathogenesis
    JAVEED ALI SHAH; Fiscal Year: 2013
    ..The regulation and nature of an optimal inflammatory response to Mycobacterium tuberculosis (MTb) remains poorly understood in humans...
  16. Acquisition of a MALDI-TOF/TOF MS for Glycomic and Lipidomic Research
    Larry S Schlesinger; Fiscal Year: 2010
    ..The major research activities described involve: i) Mycobacterium tuberculosis (M...
  17. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..by applicant): Tuberculosis (TB) is a chronic infectious disease caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)...
  18. Rapid Analysis of Single T Cell Immunity Signatures in Tuberculosis
    Sanjay Tyagi; Fiscal Year: 2013
    ..that provides tuberculosis (TB) diagnosticians with the critical ability to distinguish stable latent Mycobacterium tuberculosis infection (when the asymptomatic subject is not progressing to disease, is not infectious, and does not ..
  19. Coenzyme F420-dependent enzymes in mycobacteria
    Biswarup Mukhopadhyay; Fiscal Year: 2013
    ..This phylum includes Mycobacterium tuberculosis and Mycobacterium leprae, which cause tuberculosis (TB) and leprosy, respectively, and Streptomyces, ..
  20. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..elements are found in medically important bacteria that include but not limited to Yersinia pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus ..
  21. Structure and Mechanism of SAM-responsive Riboswitches
    Robert T Batey; Fiscal Year: 2013
    ..important pathogens including Listeria monocytogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis making them of great interest as novel targets for designing antimicrobial therapeutics...
  22. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..The initial focus will be on pathogens such as Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, however the approach has general applicability...
  23. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..b>Mycobacterium tuberculosis and Schistosoma mansoni represent epidemic pathogens for which vaccine development has been difficult to ..
  24. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..TB-FISH is Dual Probe Fluorescent In-Situ Hybridization assay for detecting and differentiating Mycobacterium tuberculosis complex (MTB) ribosomal RNA (rRNA) and Mycobacterium species (rRNA) on a SINGLE methanol fixed smear, ..
  25. Mechanistic study of the host defense functions of IL-32 in tuberculosis
    Edward D Chan; Fiscal Year: 2013
    ..of this project is to elucidate the mechanisms by which interleukin-32 (IL-32) enhances immunity against Mycobacterium tuberculosis (MTB)...
  26. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2013
    ..elucidation of these pathways, in addition to providing fundamental knowledge about the biochemistry of Mycobacterium tuberculosis, is expected to lead to the discovery of essential enzymes and transporters that could represent ..
  27. Toll-like Receptor 2, Vitamin D, and Extrapulmonary Tuberculosis
    CHRISTINA A FISKE; Fiscal Year: 2013
    ..an interesting paradox: while one-third of the world's population is estimated to be infected with Mycobacterium tuberculosis, only 5-10% of infected persons go on to develop clinical manifestations of TB...
  28. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..applicant): The pathophysiology of tuberculosis (TB) is linked to the ability of the causative organism, Mycobacterium tuberculosis (M.tb), to grow within human macrophages...
  29. Mycobacterium tuberculosis carbon metabolism in vivo
    John D McKinney; Fiscal Year: 2010
    ..and 2 (ICL2), which catalyze the first unique reaction in the glyoxylate cycle, are jointly required for Mycobacterium tuberculosis (MTB) growth, survival, and virulence in vivo...
  30. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..Experimental aerogenic infections with intracellular bacteria such as Mycobacterium tuberculosis (M...
  31. Proteome-wide screen for M. tuberculosis antigens
    Robert N Husson; Fiscal Year: 2010
    ..The overall objective of this research is to undertake a proteome-wide search for protein antigens of Mycobacterium tuberculosis (Mtb) that are recognized by the human humoral immune response...
  32. Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..for progress in the treatment of tuberculosis are to (a) develop drugs against drug resistant strains of Mycobacterium tuberculosis, (b) develop effective approaches to treat the latent states of the disease, and (c) shorten the course ..
  33. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..Recent data from intracellular pathogens (i.e. Mycobacterium tuberculosis, Listeria monocytogenes) and other fungi (i.e...
  34. A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
    Courtney C Aldrich; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading cause of bacterial infectious disease mortality. The cell envelope of M...
  35. Deciphering of the Toxin-Antitoxin Systems in E. coli
    Masayori Inouye; Fiscal Year: 2012
    ..Surprisingly, many bacteria, particularly human pathogens such as Mycobacterium tuberculosis contain a large number of independent toxin genes on their genomes...
  36. Immune-based detection of rifampicin-resistance in HIV/TB
    Gregory P Bisson; Fiscal Year: 2013
    ..are at risk of active tuberculosis (TB) because they are latently infected with the causative agent Mycobacterium tuberculosis (Mtb), and almost 2 million TB- related deaths occur annually...
  37. Novel Spectinamide Antibiotics for the Treatment of MDR/XDR Tuberculosis
    Michelle M Butler; Fiscal Year: 2013
    ..of tuberculosis (TB) therapeutic agents, the spectinamide series, for use against MDR and XDR strains of Mycobacterium tuberculosis (Mtb) and identify, through a series of in vitro and in vivo assays, a preclinical candidate...
  38. Structure and mechanism of CRISPR interference.
    Ailong Ke; Fiscal Year: 2013
    ..such as Campylobacter human jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis. It has been shown to modulate the horizontal gene transfer and biofilm formation...
  39. HIV-1 regulation by MTb: pathogen and host factor
    Anne Goldfeld; Fiscal Year: 2010
    ..b>Mycobacterium tuberculosis (MTb), the causative agent of TB, exacerbates immunological failure and disease progression in HIV-1 ..
  40. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2009
    b>Mycobacterium tuberculosis and other Mycobacterium species are major pathogens around the world...
  41. A Novel Oral Combination Pediatric HIV and TB Vaccine
    Michelle H Larsen; Fiscal Year: 2012
    ..Given the large geographical overlap between Mycobacterium tuberculosis (Mtb) and HIV infection in Africa, BCG vaccination was formerly recommended for all infants at birth to ..
  42. Characterization of wild-type and mutant initiation/elongation complexes in Esche
    Carlos Bustamante; Fiscal Year: 2012
    ..Characterization of Wild type and mutant initiation/elongation complexes in Eschericia coli and Mycobacterium tuberculosis using Atomic Force Microscopy and Optical Tweezers "This research will be done primarily in Peru at the ..
  43. SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATION
    Marlene Belfort; Fiscal Year: 2013
    ..We will investigate cisplatin's efficacy against infection by Mycobacterium tuberculosis and also test its ability to curtail activity of cryptococcal inteins...
  44. Flavin-Containing Monooxygenase in Lung
    David E Williams; Fiscal Year: 2013
    ..1). Mycobacterium tuberculosis, the causative agent in tuberculosis (TB), possesses a similar flavin monooxygenase (EtaA) that ..
  45. Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Mary Jackson; Fiscal Year: 2012
    Thiocarlide (THC), a thiourea, inhibits the synthesis of mycolic acids and fatty acids in Mycobacterium tuberculosis (M. tb)...
  46. Gene regulation and virulence in TB
    WILLIAM RAMSES BISHAI; Fiscal Year: 2013
    ..The causative agent, Mycobacterium tuberculosis, proliferates within host macrophages where it modifies both its intracellular and local tissue ..
  47. Apoptosis and efferocytosis: regulators of immunity to tuberculosis
    Samuel M Behar; Fiscal Year: 2013
    ..provided by applicant): The continuing HIV/AIDS epidemic and the spread of multi-drug resistant Mycobacterium tuberculosis (Mtb) has perpetuated an epidemic of tuberculosis in human populations around the world...
  48. M tuberculosis Membrane Protein Pharmaceutical Targets
    Timothy A Cross; Fiscal Year: 2013
    This Proposal is designed to address: 1) an important disease that needs novel drugs - no new drugs for Mycobacterium tuberculosis in 40 years and multi-drug resistant strains as well as extreme drug resistant strains are becoming more ..
  49. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human Immunodeficiency Virus type-1 (HIV) and Mycobacterium tuberculosis (Mtb) are among the leading causes of death worldwide with coinfection associated with increased mortality and greater ..
  50. EPIDEMIOLOGY OF HELICOBACTER PYLORI TRANSMISSION
    Julie Parsonnet; Fiscal Year: 2010
    ..pylori whereas latent Mycobacterium tuberculosis (LTBI) upregulates the response...
  51. Decoding the roles of critical genes of unknown function in M. tuberculosis
    Dirk Schnappinger; Fiscal Year: 2013
    ..In whole genome screens we have found hundreds of such genes in Mycobacterium tuberculosis, the causative agent of tuberculosis...
  52. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
    ..to activate ovalbumin (OVA)-specific OT-II transgenic T cells in vitro and to sensitize animals with a Mycobacterium tuberculosis antigen (Ag85A) in vivo...
  53. A Novel Approach for Mycobacterium Tuberculosis Vaccine Development
    Biao He; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is an intracellular bacterial pathogen that kills approximately 1...
  54. Screening for inhibitors of M. tuberculosis persistence-related lipid metabolism
    Robert B Abramovitch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Mycobacterium tuberculosis (Mtb) often results in a chronic tuberculosis (TB) infection...
  55. Mycobacterium turberculosis metal transport P-type ATPases
    JOSE M ARGUELLO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tuberculosis is a leading health problem worldwide. Mycobacterium tuberculosis virulence is based on its capability to reside inside macrophages...
  56. Broad-Spectrum Antimicrobials Targeting the D-Alanine Pathway
    KAREN G ANTHONY; Fiscal Year: 2013
    ..A proprietary high-throughput screening assay using recombinant Mycobacterium tuberculosis alanine racemase was developed to screen for novel enzyme inhibitors...
  57. FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM
    AUDREY RAGAN ODOM; Fiscal Year: 2013
    ..target because it is shared by other important human pathogens, including Gram-negative bacteria and Mycobacterium tuberculosis. The long-term goal is to understand why isoprenoids are essential in malaria parasites...
  58. The Mycobacterium Tuberculosis Dormancy Program
    MARTIN INUA VOSKUIL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A third of the world's population is infected with Mycobacterium tuberculosis (Mtb), and most of these infections are latent...
  59. Role of oxido-reductive stress in regulating HIV-TB coinfection
    Roy L Sutliff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Mycobacterium tuberculosis (Mtb) increases AIDS-related deaths in people living with HIV-1...
  60. Therapeutic vaccination against genital HPV infection
    Yung Nien Chang; Fiscal Year: 2013
    ..a naked DNA vaccine to significantly enhance MHC class I presentation of HPV16 E7 by its fusion to the Mycobacterium tuberculosis heat shock protein 70 (HSP70)...
  61. Novel mycobacterial translocase I inhibitors - a new class of anti-TB drugs
    Venkata M Reddy; Fiscal Year: 2010
    ..as a cornerstone drug of TB therapy because of its ability to quickly kill rapidly replicating Mycobacterium tuberculosis (MTB) in infected tissues and reduce the number of infectious bacteria in pulmonary secretions...
  62. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2010
    ..research in Pneumocystis;(2) to expand my research to include other respiratory pathogens, such as Mycobacterium tuberculosis (TB);(3) to devote more time to mentor junior patient-oriented researchers interested in pulmonary ..
  63. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tuberculosis (TB) caused by the slow growing bacillus Mycobacterium tuberculosis (Mtb) is the leading cause of infectious disease mortality in the world by a bacterial pathogen...
  64. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
    ..peptide called Inv3 was derived from a sequence based on the most active domain of a protein cloned from Mycobacterium tuberculosis called mycobacterium cell entry protein or Mcep...
  65. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..and antigen presentation mediated by a 22-amino acid peptide derived from a surface protein of Mycobacterium tuberculosis. The peptide called Inv3 was derived from a sequence based on the most active domain of a protein called ..
  66. Advancing lead dipiperidine compound into preclinical development
    Marina Protopopova; Fiscal Year: 2009
    ..evaluate the in vitro activity of SQ609 against drug-susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis (Mtb), determine the activity of SQ609 against non-replicating Mtb in vitro to assess the applicability ..
  67. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    Disseminated infection (mycobacteremia) with Mycobacterium tuberculosis (dMTB) has been documented by our group in 10-25 percent of patients with HIV infection in Africa using lysis- centrifugation blood cultures...
  68. The effect of pncA expression and POA efflux rate in the level of PZA-resistance
    Mirko J Zimic; Fiscal Year: 2010
    ..It is still the most effective drug against the latent stage of Mycobacterium tuberculosis but its mechanism of resistance is not completely understood yet...
  69. Multiplex TB-M.avium complex Fluorescent in Situ hybridization Assay, direct from
    Jyotsna Shah; Fiscal Year: 2009
    ..TB-MAC FISH assay is a fluorescent in-situ hybridization assay that detects and differentiates Mycobacterium tuberculosis complex (MTB) and Mycobacterium avium complex (MAC) in culture and sputum...
  70. Macaque model of TB/AIDS co-infection via natural routes of exposure
    Deepak Kaushal; Fiscal Year: 2010
    ..The emergence of Multi Drug-Resistant (MDR) and Extensively Drug-Resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), the failure of Bacille Calmette- Guerin (BCG) vaccine to control the spread of TB, and our ..
  71. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2003
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  72. Development of adamantyl ureas against MDR/XDR M.tb
    Mary Jackson; Fiscal Year: 2010
    ..b>Mycobacterium tuberculosis (M...
  73. Regulation of Mycobacterium tuberculosis proliferation
    Murty Madiraju; Fiscal Year: 2009
    ..One Characteristic feature of Mycobacterium tuberculosis (Mtb),, the causative agent of tuberculosiis, is its slow growth...
  74. RESPIRATOR EFFICACY VERSUS TUBERCULOSIS AEROSOLS
    John Koerner; Fiscal Year: 2000
    ..goal of this research is to protect health-care and corrections workers from occupational exposure to Mycobacterium tuberculosis by defining the performance of respiratory protection with respect to mycobacterium aerosols...
  75. Regulation of host response genes in pathogenesis of TB
    Jesse Roman; Fiscal Year: 2005
    DESCRIPTION (provided by applicant) Mycobacterium tuberculosis (Mtb) is the leading infectious cause of death worldwide...
  76. IMMUNOLOGIC BASIS ENIVR MODULATION OF AUTOIM ARTHRITIS
    KAMAL MOUDGIL; Fiscal Year: 2001
    ..Adjuvant arthritis (AA), inducible in susceptible rat strains by subcutaneous injection of heat-killed Mycobacterium tuberculosis H37Ra, serves as an excellent model for human rheumatoid arthritis (RA)...