mycobacterium bovis

Summary

Summary: The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.

Top Publications

  1. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
  2. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
  3. ncbi Mycobacterium tuberculosis: here today, and here tomorrow
    D G Russell
    Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 2:569-77. 2001
  4. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
  5. pmc Neutrophil-mediated innate immune resistance to mycobacteria
    Adrian R Martineau
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
    J Clin Invest 117:1988-94. 2007
  6. doi B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection
    Ricardo T Russo
    Discipline of Immunology, Department of Microbiology, Immunology, and Parasitology, Universidade Federal de Sao Paulo, Brazil
    Immunobiology 215:1005-14. 2010
  7. doi Mycobacterium bovis at the animal-human interface: a problem, or not?
    Anita Luise Michel
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Sciences, University of Pretoria, Private Bag X4, Onderstepoort 0110, South Africa
    Vet Microbiol 140:371-81. 2010
  8. ncbi Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 24:105-17. 2006
  9. ncbi Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
    A Scorpio
    Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Med 2:662-7. 1996
  10. pmc Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice
    Bo Young Jeon
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
    Infect Immun 76:5173-80. 2008

Research Grants

Detail Information

Publications305 found, 100 shown here

  1. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
    ..Tests of humoral (antibody) immunity, Mycobacterium bovis PCR probes on early tissue cultures or live cattle specimens, and tests based on "electronic nose" ..
  2. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
  3. ncbi Mycobacterium tuberculosis: here today, and here tomorrow
    D G Russell
    Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 2:569-77. 2001
    ..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control...
  4. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen...
  5. pmc Neutrophil-mediated innate immune resistance to mycobacteria
    Adrian R Martineau
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
    J Clin Invest 117:1988-94. 2007
    ..The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3...
  6. doi B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection
    Ricardo T Russo
    Discipline of Immunology, Department of Microbiology, Immunology, and Parasitology, Universidade Federal de Sao Paulo, Brazil
    Immunobiology 215:1005-14. 2010
    ..cultured B-1 cells, we investigated the influence of these cells on some of the immune events triggered by Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice...
  7. doi Mycobacterium bovis at the animal-human interface: a problem, or not?
    Anita Luise Michel
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Sciences, University of Pretoria, Private Bag X4, Onderstepoort 0110, South Africa
    Vet Microbiol 140:371-81. 2010
    b>Mycobacterium bovis is a pathogen of significant importance in livestock and a wide range of wild animal species worldwide...
  8. ncbi Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 24:105-17. 2006
    ..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...
  9. ncbi Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
    A Scorpio
    Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Med 2:662-7. 1996
    Naturally pyrazinamide (PZA)-resistant Mycobacterium bovis and acquired PZA-resistant M. tuberculosis strains lose pyrazinamidase (PZase)...
  10. pmc Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice
    Bo Young Jeon
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
    Infect Immun 76:5173-80. 2008
    ..certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity...
  11. pmc Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan
    Junji Uehori
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Infect Immun 71:4238-49. 2003
    The Mycobacterium bovis bacillus Calmette-Guérin (BCG) cell wall skeleton (CWS) consists of mycolic acids, arabinogalactan, and peptidoglycan (PGN) and activates Toll-like receptor 2 (TLR2) and TLR4...
  12. ncbi The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: how to assess the risk
    L A L Corner
    Department of Large Animal Clinical Studies, University College Dublin, Dublin, Ireland
    Vet Microbiol 112:303-12. 2006
    ..A detailed analysis of Mycobacterium bovis infection in the Eurasian badger (Meles meles) in Ireland and their role as a reservoir of infection for ..
  13. doi Gene expression profiling of the host response to Mycobacterium bovis infection in cattle
    D E MacHugh
    Animal Genomics Laboratory, UCD School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Dublin, Ireland
    Transbound Emerg Dis 56:204-14. 2009
    Bovine tuberculosis (BTB), caused by Mycobacterium bovis, continues to pose a threat to livestock worldwide and, as a zoonotic infection, also has serious implications for human health...
  14. ncbi Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1
    Y Moriwaki
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537, Japan
    J Biol Chem 276:23065-76. 2001
    ..By using the differential display approach, we identified a Mycobacterium bovis BCG cell wall skeleton (BCG-CWS)-inducible gene fragment from human monocytes, showing no homology to any ..
  15. ncbi Positive and negative effects of widespread badger culling on tuberculosis in cattle
    Christl A Donnelly
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 439:843-6. 2006
    ..Meles meles) have been culled by the British government in a series of attempts to limit the spread of Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), to cattle...
  16. pmc Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis
    Jeanne M DiChiara
    Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201 2002, USA
    Nucleic Acids Res 38:4067-78. 2010
    ..tuberculosis could be functioning in mediation of virulence, thus rendering them potential targets for novel antimycobacterials. Various features and regulatory aspects of some of these sRNAs are discussed...
  17. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
    ..Our study thus identifies TNF-alpha as a type 1 immunoregulatory cytokine whose primary role, different from those of other type 1 cytokines, is to keep an otherwise detrimental type 1 immune response in check...
  18. doi Evidence of genetic resistance of cattle to infection with Mycobacterium bovis
    S Brotherstone
    School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Dairy Sci 93:1234-42. 2010
    Anecdotal evidence points to genetic variation in resistance of cattle to infection with Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), and published experimental evidence in deer and cattle suggests significant ..
  19. pmc The duration of the effects of repeated widespread badger culling on cattle tuberculosis following the cessation of culling
    Helen E Jenkins
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9090. 2010
    ..However, a full assessment of the utility of badger culling requires information on the duration of culling effects...
  20. ncbi Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
    F Altare
    INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
    Science 280:1432-5. 1998
    ..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
  21. doi Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages
    Heloisa D'Avila
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Cell Microbiol 10:2589-604. 2008
    ..The uptake of apoptotic neutrophils by macrophages leads to TGF-beta1 generation and PGE(2)-derived lipid body formation, and may have modulator roles in mycobacterial pathogenesis...
  22. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
    ..To address these questions, cattle were vaccinated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) and were then challenged with virulent M. bovis...
  23. doi Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis
    Patricia E Almeida
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Immunol 183:1337-45. 2009
    ..the molecular mechanisms underlying the formation of macrophage lipid bodies (lipid droplets) during Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, focusing on the role of the lipid-activated nuclear receptor ..
  24. pmc Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia
    Gobena Ameni
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
    Vet J 188:359-61. 2011
    ..bovis. The practice of local farmers discharging chewed tobacco directly into the mouths of pastured cattle was identified as a potential route of human-to-cattle transmission of M. tuberculosis...
  25. ncbi Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo
    Heloisa D'Avila
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    J Immunol 176:3087-97. 2006
    ..b>Mycobacterium bovis bacillus Calmette-Guérin (BCG), but not Mycobacterium smegmatis, induced a dose- and time-dependent ..
  26. pmc A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis
    Puiying A Mak
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, United States
    ACS Chem Biol 7:1190-7. 2012
    ..Approximately 800 compounds were confirmed to reduce intracellular ATP levels in a dose-dependent manner in Mycobacterium bovis BCG. One hundred and forty non-cytotoxic compounds with activity against hypoxic non-replicating M...
  27. doi Mycobacterium bovis infection in the Eurasian badger (Meles meles): the disease, pathogenesis, epidemiology and control
    L A L Corner
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
    J Comp Pathol 144:1-24. 2011
    Eurasian badgers (Meles meles) are an important wildlife reservoir of tuberculosis (Mycobacterium bovis) infection in Ireland and the United Kingdom...
  28. doi Recurrence of bovine tuberculosis breakdowns in Great Britain: risk factors and prediction
    K Karolemeas
    Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, CB3 0ES, UK
    Prev Vet Med 102:22-9. 2011
    ..These variables are indicative of a higher level of infection or residual infection, and could be useful in the future development of predictive models for bTB recurrence...
  29. pmc Early antibody responses to experimental Mycobacterium bovis infection of cattle
    W R Waters
    Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:648-54. 2006
    ..Sequential serum samples obtained from Mycobacterium bovis-infected cattle were evaluated for seroreactivity to mycobacterial antigens. Animals received M...
  30. pmc Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses
    Mark J Cayabyab
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 83:5505-13. 2009
    ..We successfully generated recombinant Mycobacterium bovis BCG (rBCG) expressing simian immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors,..
  31. pmc Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis
    Elma Z Tchilian
    The Jenner Institute, Oxford University, ORCRB, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom
    Infect Immun 77:622-31. 2009
    ..of tuberculosis (TB) in populations coinfected with human immunodeficiency virus, and the failure of Mycobacterium bovis bacillus Calmette-Guerin (BCG) to protect against disease, new vaccines against TB are urgently needed...
  32. ncbi Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organism
    R Glyn Hewinson
    TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 112:127-39. 2006
    Significant and rapid progress has been made in our knowledge and understanding of Mycobacterium bovis since the last international M. bovis conference 5 years ago...
  33. ncbi The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
    K Pethe
    Unité INSERM U447, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille cedex, France
    Nature 412:190-4. 2001
    ..tuberculosis has been identified to date. Here we show that the disruption of the M. tuberculosis or Mycobacterium bovis Bacille Calmette-Guérin (BCG) hbhA gene encoding the heparin-binding haemagglutinin adhesin (HBHA) ..
  34. ncbi Evaluation of blood assays for detection of Mycobacterium bovis in white-tailed deer (Odocoileus virginianus) in Michigan
    Daniel J O'Brien
    Wildlife Disease Laboratory, Michigan Department of Natural Resources, 4125 Beaumont Rd, Room 250, Lansing, Michigan 48910 8106, USA
    J Wildl Dis 45:153-64. 2009
    ..This study demonstrated the capabilities and limitations of several available blood tests for Mycobacterium bovis on specimens obtained through a variety of field surveillance methods...
  35. doi Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guérin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains
    Masaaki Seki
    Japan BCG Laboratory, Research of Product, 3 1 5 Matsuyama, Kiyose City, Tokyo 204 0022, Japan
    Vaccine 27:1710-6. 2009
    ..the molecular characteristics of bacillus Calmette-Guérin (BCG) vaccines, the complete genomic sequence of Mycobacterium bovis BCG Tokyo 172 was determined, and the results were compared with those for BCG Pasteur and other M...
  36. pmc Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosis
    Lihao Chen
    Infectious Diseases Division, Center for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Infect Immun 72:238-46. 2004
    Whether the intranasal (i.n.) route of Mycobacterium bovis BCG vaccination provides better protection against pulmonary tuberculosis than subcutaneous (s.c.) vaccination remains an incompletely solved issue...
  37. ncbi Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophages
    Michel Denis
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 87:53-62. 2007
    ..bovis growth in infected macrophages by an unclear mechanism, and are potentially involved in innate resistance of cattle to tuberculosis...
  38. ncbi Survival of Mycobacterium bovis on feedstuffs commonly used as supplemental feed for white-tailed deer (Odocoileus virginianus)
    Mitchell V Palmer
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa, USA
    J Wildl Dis 42:853-8. 2006
    b>Mycobacterium bovis, the causative agent of bovine tuberculosis, has become established in free-ranging white-tailed deer Odocoileus virginianus in northeastern Michigan...
  39. doi Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reserves
    A L Michel
    ARC Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa
    Vet Microbiol 133:335-43. 2009
    ..The molecular characterisation of 189 Mycobacterium bovis isolates from nine wildlife species in the HiP, including three smaller associated parks, and the Kruger ..
  40. pmc Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors
    S Tsuji
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Infect Immun 68:6883-90. 2000
    ..In this study, we demonstrated that the cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin (BCG-CWS), a purified noninfectious material consisting of peptidoglycan, ..
  41. pmc Identification of a heparin-binding hemagglutinin present in mycobacteria
    F D Menozzi
    Laboratoire de Microbiologie Genetique et Moléculare, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, France
    J Exp Med 184:993-1001. 1996
    ..chromatography, a 28-kD heparin-binding protein was purified from culture supernatants and cell extracts of Mycobacterium bovis and Mycobacterium tuberculosis...
  42. doi Animal-side serologic assay for rapid detection of Mycobacterium bovis infection in multiple species of free-ranging wildlife
    K P Lyashchenko
    Chembio Diagnostic Systems, Inc, 3661 Horseblock Road, Medford, NY 11763, USA
    Vet Microbiol 132:283-92. 2008
    Numerous species of mammals are susceptible to Mycobacterium bovis, the causative agent of bovine tuberculosis (TB). Several wildlife hosts have emerged as reservoirs of M. bovis infection for domestic livestock in different countries...
  43. pmc Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L
    Troy J Kemp
    Department of Urology, Interdisciplinary Graduate Program in Immunolgy, University of Iowa, Iowa City, 52242, USA
    Blood 106:3474-82. 2005
    b>Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used to treat bladder cancer for almost 30 years; however, the effector mechanism of the BCG-induced antitumor response remains enigmatic...
  44. pmc Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferon
    Teresa M Wozniak
    Centenary Institute, Newtown, NSW, Australia
    Infect Immun 78:4187-94. 2010
    ..Therefore, Th17 cells can provide IFN-γ-independent protection against M. tuberculosis, and this effect may contribute to the early control of M. tuberculosis infection...
  45. ncbi The transmission of Mycobacterium bovis infection to cattle
    C J C Phillips
    Department of Clinical Veterinary Medicine, University of Cambridge, CB3 0ES, Cambridge, UK
    Res Vet Sci 74:1-15. 2003
    The prevalence of Mycobacterium bovis infection in cattle is increasing rapidly in some countries, including the UK and Ireland...
  46. ncbi Epizootiologic survey of Mycobacterium bovis in wildlife and farm environments in northern Michigan
    Gary Witmer
    US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Ave, Fort Collins, Colorado 80521 2154, USA
    J Wildl Dis 46:368-78. 2010
    Bovine tuberculosis (bovine TB), caused by Mycobacterium bovis, has reemerged in northern Michigan, USA, with detections in white-tailed deer (Odocoileus virginianus) in 1994 and in cattle in 1998...
  47. ncbi Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovis
    Kelly L Diegel
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 38:275-81. 2002
    Eight North American opossums (Didelphis virginiana) were inoculated with 1 x 10(5) colony forming units of Mycobacterium bovis to investigate their potential as reservoir hosts for bovine tuberculosis in Michigan...
  48. doi Mycobacterium bovis lipids: virulence and vaccines
    Grant S Hotter
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Vet Microbiol 151:91-8. 2011
    b>Mycobacterium bovis is an important pathogen of both domesticated and wild animals in many countries, and improved vaccines have great potential to assist in its control and eventual eradication...
  49. pmc Apoptosis-inducing factor participation in bovine macrophage Mycobacterium bovis-induced caspase-independent cell death
    X Vega-Manriquez
    Departamento de Microbiologia e Inmunologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Circuito exterior s n, Ciudad Universitaria, Coyoacan 04510, Mexico City, Mexico
    Infect Immun 75:1223-8. 2007
    ..Previously, our group demonstrated macrophage apoptosis as a consequence of Mycobacterium bovis infection. In this study, we aimed to identify the contribution of apoptotic effector elements in M...
  50. pmc The complete genome sequence of Mycobacterium bovis
    Thierry Garnier
    Unité de Génétique Moléculaire Bactérienne and PT4 Annotation, Genopole, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:7877-82. 2003
    b>Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion...
  51. ncbi Bovine tuberculosis in wild boar (Sus scrofa), red deer (Cervus elaphus) and cattle (Bos taurus) in a Mediterranean ecosystem (1992-2004)
    J Hermoso De Mendoza
    Patología Infecciosa, Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain
    Prev Vet Med 74:239-47. 2006
    ..It is imperative to investigate the epidemiology of Mycobacterium bovis infection in red deer and wild boar in order to keep a good health status and to maintain the effectiveness ..
  52. doi Advances in ante-mortem diagnosis of tuberculosis in cattle
    B M Buddle
    AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
    N Z Vet J 57:173-80. 2009
    The tuberculin skin test is effective in the early detection of pre-clinical cases of Mycobacterium bovis infection in cattle...
  53. pmc African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa
    Stefan Berg
    VLA Weybridge, New Haw, Surrey KT15 3NB, United Kingdom
    J Bacteriol 193:670-8. 2011
    We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M...
  54. ncbi Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great Britain
    R Daniel
    Veterinary Laboratories Agency VLA Carmarthen, Job s Well Road, Johnstown, Carmarthen SA31 3EZ
    Vet Rec 165:335-42. 2009
    An outbreak of caprine tuberculosis caused by Mycobacterium bovis was disclosed in June 2008, affecting goats of the golden Guernsey breed kept on 10 separate smallholdings in south-west Wales and the west of England...
  55. pmc Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations
    Natalie E R Beveridge
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 37:3089-100. 2007
    ..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
  56. doi The effects of annual widespread badger culls on cattle tuberculosis following the cessation of culling
    Helen E Jenkins
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
    Int J Infect Dis 12:457-65. 2008
    ....
  57. ncbi Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana)
    Scott D Fitzgerald
    Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 39:418-23. 2003
    ..to evaluate the susceptibility of North American opossums (Didelphis virginiana) to aerosol inoculation of Mycobacterium bovis at two dose levels in order to gain information on disease pathogenesis, fecal shedding of the organism, ..
  58. pmc Mycobacterium leprae actively modulates the cytokine response in naive human monocytes
    Daniel Sinsimer
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Infect Immun 78:293-300. 2010
    ..leprae compared with Mycobacterium bovis BCG stimulation. Interestingly, although in itself a weak stimulator of cytokines, M...
  59. pmc Fine-tuning the space, time, and host distribution of mycobacteria in wildlife
    Christian Gortazar
    IREC National Wildlife Research Institute CSIC UCLM JCCM, Ciudad Real, Spain
    BMC Microbiol 11:27. 2011
    We describe the diversity of two kinds of mycobacteria isolates, environmental mycobacteria and Mycobacterium bovis collected from wild boar, fallow deer, red deer and cattle in Doñana National Park (DNP, Spain), analyzing their ..
  60. ncbi Tuberculosis in badgers; a review of the disease and its significance for other animals
    J Gallagher
    Central Veterinary Laboratory, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Res Vet Sci 69:203-17. 2000
    ..Trials of the effects of the removal of badgers on the occurrence of tuberculosis in cattle are summarised. It is concluded that badgers are well adapted as the primary host of bovine tuberculosis in parts of Britain and much of Ireland...
  61. doi Management of bovine tuberculosis in Michigan wildlife: current status and near term prospects
    Daniel J O'Brien
    Wildlife Disease Laboratory, Michigan Department of Natural Resources, 4125 Beaumont Road, Lansing, MI 48910 8106, USA
    Vet Microbiol 151:179-87. 2011
    ..Yet formidable challenges remain, and evidence suggests that eradication of bTB, if it can be achieved, will take decades, and will require greater public and political resolve than has been demonstrated thus far...
  62. doi Analysis of the spatial variation of Bovine tuberculosis disease risk in Spain (2006-2009)
    A Allepuz
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Prev Vet Med 100:44-52. 2011
    ..This study has identified some specific areas of increased BTB risk in Spain, information that is useful for disease management...
  63. pmc Simultaneous measurement of antigen-stimulated interleukin-1 beta and gamma interferon production enhances test sensitivity for the detection of Mycobacterium bovis infection in cattle
    Gareth J Jones
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Vaccine Immunol 17:1946-51. 2010
    In order to identify cytokines that may be useful as candidates for inclusion in diagnostic tests for Mycobacterium bovis infection in cattle, we compared the levels of gamma interferon (IFN-γ), interleukin 1β (IL-1β), IL-4, IL-10, IL-..
  64. pmc Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 8:571-8. 2001
    ..scientific review for the government has concluded that the development of a cattle vaccine against Mycobacterium bovis infection holds the best long-term prospect for tuberculosis control in British herds...
  65. ncbi Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selection
    Vikas Srivastava
    Microbiology Division, Central Drug Research Institute, Lucknow, India
    Microbiology 153:659-66. 2007
    ..In addition, an M. tuberculosis genomic DNA library was inserted into pLL192 and then introduced into Mycobacterium bovis BCG. The recombinant BCG cells were then used to infect the J774A...
  66. ncbi IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection
    Masayuki Umemura
    Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    J Immunol 178:3786-96. 2007
    ..also in T cell-mediated IFN-gamma production and granuloma formation in response to pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin (BCG)...
  67. doi European 1: a globally important clonal complex of Mycobacterium bovis
    Noel H Smith
    Centre for Study of Evolution, University of Sussex, Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Surrey KT15 3NB, UK
    Infect Genet Evol 11:1340-51. 2011
    We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M...
  68. ncbi Susceptibility of raccoons (Procyon lotor) to infection with Mycobacterium bovis
    Mitchell V Palmer
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Services, USDA, 2300 N Dayton Avenue, Ames, Iowa 50010, USA
    J Wildl Dis 38:266-74. 2002
    Tuberculosis due to Mycobacterium bovis infection is endemic in white-tailed deer (Odocoileus virginianus) in the northeastern portion of the lower Michigan peninsula (USA)...
  69. ncbi Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice
    Rachel A Moulton
    Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center, 6431 Fannin, Houston, TX 77030, USA
    J Leukoc Biol 82:956-67. 2007
    During acquired immunity to Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice, dendritic cells (DCs) present mycobacterial antigens to naive T cells to prime an immune response...
  70. pmc Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
    Kate E Killick
    UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Genomics 12:611. 2011
    b>Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact...
  71. pmc Use of cattle farm resources by badgers (Meles meles) and risk of bovine tuberculosis (Mycobacterium bovis) transmission to cattle
    B T Garnett
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Proc Biol Sci 269:1487-91. 2002
    ..The badgers, which included three individuals infected with bovine tuberculosis (Mycobacterium bovis), used cowsheds, feedsheds, barns, haystacks, slurry pits, cattle troughs and farmyards to exploit a range ..
  72. pmc Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice
    S A Fulton
    Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984, USA
    Infect Immun 70:5322-7. 2002
    ..In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs...
  73. ncbi The effect of tuberculin testing on the development of cell-mediated immune responses during Mycobacterium bovis infection
    M L Thom
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Vet Immunol Immunopathol 114:25-36. 2006
    ..effect on CMI responses, groups of 6-month old calves were inoculated intranasally with 8 x 10(4) cfu of Mycobacterium bovis, subjected to the comparative intradermal tuberculin test (TT) using bovine and avian PPD (PPD-B, PPD-A) at ..
  74. pmc Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-Guérin
    Dilara Begum
    Molecular Microbiology Group, COMB, Tropical Biosphere Research Center, Univeristy of the Ryukyus, Okinawa, Japan
    Immunology 128:556-63. 2009
    ..To evaluate the effect of vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) on the CD8(+) T-cell response to pulmonary M...
  75. pmc Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis
    Nele Festjens
    Unit for Medical Biotechnology, Department for Molecular Biomedical Research, Ghent, Belgium
    EMBO Mol Med 3:222-34. 2011
    b>Mycobacterium bovis bacille Calmette-Guerin (BCG) provides only limited protection against pulmonary tuberculosis...
  76. ncbi Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination
    David K Flaherty
    Department of Internal Medicine, Division of Infectious Diseases, Center for Microbial Interface Biology, 420 West 12th Avenue, Columbus, OH 43210, USA
    J Leukoc Biol 80:1262-71. 2006
    b>Mycobacterium bovis bacille Calmette Guerin (BCG), the current vaccine against infection with Mycobacterium tuberculosis, offers a variable, protective efficacy in man...
  77. ncbi Investigation of the transmission of Mycobacterium bovis from deer to cattle through indirect contact
    Mitchell V Palmer
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, 2300 Dayton Ave, Ames, IA 50010, USA
    Am J Vet Res 65:1483-9. 2004
    To investigate the infection of calves with Mycobacterium bovis through oral exposure and transmission of M. bovis from experimentally infected white-tailed deer to uninfected cattle through indirect contact.
  78. ncbi Estimating the true prevalence of Mycobacterium bovis in hunter-harvested white-tailed deer in Michigan
    Daniel J O'Brien
    Rose Lake Wildlife Disease Laboratory, Michigan Department of Natural Resources, 8562 E Stoll Rd, East Lansing, Michigan 48823, USA
    J Wildl Dis 40:42-52. 2004
    ..In Michigan, the ability to estimate the true prevalence of bovine tuberculosis (TB; caused by Mycobacterium bovis) in free-ranging white-tailed deer (Odocoileus virginianus) will become increasingly important to ..
  79. ncbi Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam) assay
    E Gormley
    Large Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Dublin 4, Ireland
    Vet Microbiol 112:171-9. 2006
    ..use of the gamma-interferon (IFN-gamma) assay (Bovigam) can provide a means for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal from an infected herd...
  80. ncbi Mycobacterium caprae in cattle and humans in Croatia
    Z Cvetnic
    Croatian Veterinary Institute Zagreb, Zagreb, Croatia
    Int J Tuberc Lung Dis 11:652-8. 2007
    ..The children came from a family that ran a small-sized cattle dairy farm...
  81. doi Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovis
    Leigh A L Corner
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
    Tuberculosis (Edinb) 88:601-9. 2008
    b>Mycobacterium bovis is endemic in badger (Meles meles) populations of Ireland and the United Kingdom and infected badgers are a potential source of infection for cattle...
  82. pmc Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattle
    Clare Whelan
    Enfer Scientific, Unit T, M7 Business Park, Newhall, Naas, County Kildare, Ireland
    Clin Vaccine Immunol 15:1834-8. 2008
    ..system and analyzed with a macro program that tracks each serum for its pattern of antibody activity for Mycobacterium bovis antigens...
  83. pmc Infection of Acanthamoeba castellanii with Mycobacterium bovis and M. bovis BCG and survival of M. bovis within the amoebae
    Stephanie J Taylor
    Microbial Sciences Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    Appl Environ Microbiol 69:4316-9. 2003
    Survival of Mycobacterium bovis after ingestion by protozoa would provide an environmental reservoir for infection of cattle. We have shown that M. bovis survived ingestion by Acanthamoeba castellanii. In contrast, two strains of M...
  84. ncbi inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    A Banerjee
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 263:227-30. 1994
    ..These results suggest that InhA is likely a primary target of action for INH and ETH...
  85. doi Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 151:8-13. 2011
    ..progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test)...
  86. doi Early response of bovine alveolar macrophages to infection with live and heat-killed Mycobacterium bovis
    Stephanie Widdison
    Livestock Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK
    Dev Comp Immunol 35:580-91. 2011
    ..role in the immune response to TB and recent studies provide insights into the interactions between Mϕ and Mycobacterium bovis. Here we reveal the early transcriptional response of bovine AlvMϕ to M. bovis infection...
  87. ncbi Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004-2007
    E Rodriguez
    National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Int J Tuberc Lung Dis 13:1536-41. 2009
    To identify the characteristics associated with human tuberculosis (TB) caused by Mycobacterium bovis and M. caprae in Spain.
  88. pmc Molecular typing of Mycobacterium bovis strains isolated in Italy from 2000 to 2006 and evaluation of variable-number tandem repeats for geographically optimized genotyping
    M Beatrice Boniotti
    Centro Nazionale di Referenza per la Tubercolosi Bovina, Istituto Zooprofilattico Sperimentale Lombardia e Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy
    J Clin Microbiol 47:636-44. 2009
    Spoligotyping and exact tandem repeat (ETR) analysis of Mycobacterium bovis and M...
  89. doi Oral vaccination of badgers (Meles meles) with BCG and protective immunity against endobronchial challenge with Mycobacterium bovis
    Leigh A L Corner
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
    Vaccine 28:6265-72. 2010
    Eurasian badgers (Meles meles) are a reservoir host of Mycobacterium bovis and are implicated in the transmission of tuberculosis to cattle in Ireland and Great Britain...
  90. pmc Tuberculosis immunity: opportunities from studies with cattle
    W Ray Waters
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
    Clin Dev Immunol 2011:768542. 2011
    ..Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals...
  91. pmc Identification of a Mycobacterium bovis BCG 45/47-kilodalton antigen complex, an immunodominant target for antibody response after immunization with living bacteria
    F Romain
    Unité de Physiopathologie de l Infection, Institut Pasteur, Paris, France
    Infect Immun 61:742-50. 1993
    ..tuberculosis is induced mainly by a previous immunization with living avirulent mycobacteria, usually Mycobacterium bovis BCG...
  92. pmc The impact of transcriptomics on the fight against tuberculosis: focus on biomarkers, BCG vaccination, and immunotherapy
    Carlos Rodrigo Zarate-Blades
    The Centre for Tuberculosis Research, Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
    Clin Dev Immunol 2011:192630. 2011
    ....
  93. ncbi Estimating the true prevalence of Mycobacterium bovis in free-ranging elk in Michigan
    Daniel J O'Brien
    Wildlife Disease Laboratory, Michigan Department of Natural Resources, Lansing, Michigan 48910 8106, USA
    J Wildl Dis 44:802-10. 2008
    ..Elk and red deer (Cervus elaphus elaphus) are highly susceptible to infection with Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), and outbreaks have been documented worldwide...
  94. pmc Molecular detection of Mycobacterium bovis and Mycobacterium bovis BCG (Pasteur) in soil
    Jamie S Young
    Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom
    Appl Environ Microbiol 71:1946-52. 2005
    PCR primers specific for the Mycobacterium tuberculosis complex were used to detect the presence of Mycobacterium bovis BCG (Pasteur) in soil microcosms and Mycobacterium bovis in environmental samples taken from a farm in Ireland with a ..
  95. pmc Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin
    Manjunatha M Venkataswamy
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY10461, USA
    J Immunol 183:1644-56. 2009
    The attenuated strain of Mycobacterium bovis known as bacille Calmette-Guérin (BCG) has been widely used as a vaccine for prevention of disease by Mycobacterium tuberculosis, but with relatively little evidence of success...
  96. ncbi Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity
    Janice J Endsley
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, United States
    Vaccine 25:8384-94. 2007
    ..used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG)...
  97. pmc Mycobacterium bovis with different genotypes and from different hosts induce dissimilar immunopathological lesions in a mouse model of tuberculosis
    D Aguilar Leon
    Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition, Salvador Zubiran, Mexico City, Mexico
    Clin Exp Immunol 157:139-47. 2009
    With the hypothesis that genetic variability of Mycobacterium bovis could influence virulence and immunopathology, five M...
  98. pmc Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis
    Sylvie Bertholet
    Infectious Disease Research Institute, Seattle WA 98104, USA
    J Immunol 181:7948-57. 2008
    ..This study identified numerous novel human T cell Ags suitable to be included in subunit vaccines against tuberculosis...
  99. ncbi Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages
    Janice J Endsley
    Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Leukoc Biol 79:71-9. 2006
    ..of granulysin, interferon-gamma, and perforin and have cytotoxic activity against human tumor cells and Mycobacterium bovis bacillus Calmette-Guerin-infected alveolar and monocyte-derived macrophages...
  100. pmc Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries
    Ludovic de Beaucoudrey
    Laboratory of Human Genetics of Infectious Diseases U980, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Medicine (Baltimore) 89:381-402. 2010
    ..The condition has higher clinical penetrance, broader susceptibility to infections, and less favorable outcome than previously thought...
  101. pmc Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7
    N R Chu
    StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Exp Immunol 121:216-25. 2000
    ..carcinoma, an immunotherapy based on the administration of an adjuvant-free fusion protein comprising Mycobacterium bovis BCG heat shock protein (hsp)65 linked to HPV16 E7 (hspE7) has been developed...

Research Grants73

  1. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2010
    ..This hypothesis will be tested under conditions of Mycobacterium bovis and Schistosoma mansoni exposure by way of the following aims...
  2. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Carol Clayberger; Fiscal Year: 2003
    ..b>Mycobacterium bovis Bacille Calmette-Guerin (BCG), the current anti-TB vaccine, is quite variable in its ability to protect ..
  3. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Carol Clayberger; Fiscal Year: 2006
    ..b>Mycobacterium bovis Bacille Calmette-Guerin (BCG), the current anti-TB vaccine, is quite variable in its ability to protect ..
  4. DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICIENCY
    David McMurray; Fiscal Year: 1999
    ..will be applied in experiments which are designed to address the following specific aims: (1) To utilize Mycobacterium bovis BCG and attenuated Mycobacterium tuberculosis H37Ra in order to establish the importance of homology ..
  5. A Novel Oral Combination Pediatric HIV and TB Vaccine
    Michelle H Larsen; Fiscal Year: 2010
    ..However, for obvious safety reasons, live attenuated HIV vaccination is not feasible. Mycobacterium bovis bacilli Calmette-Guerin (BCG) vaccination induces strong T helper 1 (Th1) responses in human infants...
  6. Gene Therapy for the Wiskott Aldrich Syndrome
    TED STROM; Fiscal Year: 2007
    ..The applicant's preliminary data have established sensitivity to challenge with mycobacterium bovis and influenza in the murine WAS model providing quantifiable assays for evaluating the effects of gene ..
  7. Role of WhiB3 in M. tuberculosis virulence
    ADRIE STEYN; Fiscal Year: 2007
    ..2 domain of RpoV, the principal sigma factor in Mycobacterium bovis, is attenuating. Using the yeast two-hybrid system, we have established that the 4...
  8. The Role of SP-A in Pulmonary Host Defense
    VIRGINIA SHEPHERD; Fiscal Year: 2004
    ..We have shown in preliminary studies that Mycobacterium bovis BCG and Mycobacterium avium internalization by macrophages is enhanced by opsonization with SP-A...
  9. MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
    Carl Nathan; Fiscal Year: 2003
    ..We will focus first on AhpC, recently shown to be a virulence factor for Mycobacterium bovis, and analyze the impact of mutations, its biochemical mechanism and its expression in Mtb...
  10. Mechanisms of Regulation of Autoimmune Th1 CD4 T cells
    DYANA DALTON; Fiscal Year: 2007
    ..IFN-y and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
  11. Mechanisms of Regulation of Autoimmune Th1 CD4 T cells
    DYANA DALTON; Fiscal Year: 2006
    ..IFN-gamma and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
  12. Mechanisms of Regulation of Autoimmune Th1 CD4 T cells
    DYANA DALTON; Fiscal Year: 2003
    ..IFN-gamma and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
  13. SP-A Receptor Modulation of Macrophage Phagocytosis
    Zissis Chroneos; Fiscal Year: 2004
    ..To facilitate these studies we will utilize immature alveolar macrophages that we have isolated, and Mycobacterium bovis BCG and Mycobacterium tuberculosis Ra reporter strains that express green fluorescent protein...
  14. Nonpathogenic Mycobacteria:Anti-Bladder Tumor Therapy
    Glenn Fennelly; Fiscal Year: 2005
    ..In particular, we will study the efficacy of wild type Mycobacterium smegmatis, and Mycobacterium bovis BCG, or alternative modified mycobacteria, for the delivery of genes that express functional cytokines or ..
  15. Unraveling the Molecular Mechanisms of Phagocytosis(RMI)
    Fabienne Paumet; Fiscal Year: 2005
    ..infectious disease is tuberculosis caused by mycobacterium tuberculosis (and to much lesser extent mycobacterium bovis). M...
  16. T Cell- Mediated Immunity to Mycobacterial Infection
    Matthew Williams; Fiscal Year: 2005
    ..In contrast, Mycobacterium bovis bacillus Calmette-Guerin (BCG) persists in the face of detectable CD4 and CD8 T cell responses, with much ..