Genomes and Genes
Summary: The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Publications264 found, 100 shown here
- Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in miceEmily K Forbes
The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
J Immunol 181:4955-64. 2008..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
- Multiple defects of immune cell function in mice with disrupted interferon-gamma genesD K Dalton
Genentech Inc, South San Francisco, CA 94080
Science 259:1739-42. 1993..IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen...
- Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniquesR de la Rua-Domenech
Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
Res Vet Sci 81:190-210. 2006..Tests of humoral (antibody) immunity, Mycobacterium bovis PCR probes on early tissue cultures or live cattle specimens, and tests based on "electronic nose"..
- IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infectionMasayuki Umemura
Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
J Immunol 178:3786-96. 2007..also in T cell-mediated IFN-gamma production and granuloma formation in response to pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin (BCG)...
- Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populationsNatalie E R Beveridge
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Eur J Immunol 37:3089-100. 2007..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
- Animal-side serologic assay for rapid detection of Mycobacterium bovis infection in multiple species of free-ranging wildlifeK P Lyashchenko
Chembio Diagnostic Systems, Inc, 3661 Horseblock Road, Medford, NY 11763, USA
Vet Microbiol 132:283-92. 2008Numerous species of mammals are susceptible to Mycobacterium bovis, the causative agent of bovine tuberculosis (TB). Several wildlife hosts have emerged as reservoirs of M. bovis infection for domestic livestock in different countries...
- Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosisFlorian Winau
Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
Immunity 24:105-17. 2006..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...
- Gene expression profiling of the host response to Mycobacterium bovis infection in cattleD E MacHugh
Animal Genomics Laboratory, UCD School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Dublin, Ireland
Transbound Emerg Dis 56:204-14. 2009Bovine tuberculosis (BTB), caused by Mycobacterium bovis, continues to pose a threat to livestock worldwide and, as a zoonotic infection, also has serious implications for human health...
- Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatisJeanne M DiChiara
Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201 2002, USA
Nucleic Acids Res 38:4067-78. 2010..tuberculosis could be functioning in mediation of virulence, thus rendering them potential targets for novel antimycobacterials. Various features and regulatory aspects of some of these sRNAs are discussed...
- Evidence of genetic resistance of cattle to infection with Mycobacterium bovisS Brotherstone
School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
J Dairy Sci 93:1234-42. 2010Anecdotal evidence points to genetic variation in resistance of cattle to infection with Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), and published experimental evidence in deer and cattle suggests significant ..
- Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-GuÃ©rin peptidoglycanJunji Uehori
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan
Infect Immun 71:4238-49. 2003The Mycobacterium bovis bacillus Calmette-GuÃ©rin (BCG) cell wall skeleton (CWS) consists of mycolic acids, arabinogalactan, and peptidoglycan (PGN) and activates Toll-like receptor 2 (TLR2) and TLR4...
- The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: how to assess the riskL A L Corner
Department of Large Animal Clinical Studies, University College Dublin, Dublin, Ireland
Vet Microbiol 112:303-12. 2006..A detailed analysis of Mycobacterium bovis infection in the Eurasian badger (Meles meles) in Ireland and their role as a reservoir of infection for ..
- Mycobacterium tuberculosis: here today, and here tomorrowD G Russell
Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
Nat Rev Mol Cell Biol 2:569-77. 2001..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control...
- Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillusA Scorpio
Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Nat Med 2:662-7. 1996Naturally pyrazinamide (PZA)-resistant Mycobacterium bovis and acquired PZA-resistant M. tuberculosis strains lose pyrazinamidase (PZase)...
- Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in miceBo Young Jeon
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 76:5173-80. 2008..certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity...
- Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosisH Martin Vordermeier
Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Infect Immun 70:3026-32. 2002..To address these questions, cattle were vaccinated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) and were then challenged with virulent M. bovis...
- Survival of Mycobacterium bovis on feedstuffs commonly used as supplemental feed for white-tailed deer (Odocoileus virginianus)Mitchell V Palmer
United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa, USA
J Wildl Dis 42:853-8. 2006b>Mycobacterium bovis, the causative agent of bovine tuberculosis, has become established in free-ranging white-tailed deer Odocoileus virginianus in northeastern Michigan...
- Evaluation of blood assays for detection of Mycobacterium bovis in white-tailed deer (Odocoileus virginianus) in MichiganDaniel J O'Brien
Wildlife Disease Laboratory, Michigan Department of Natural Resources, 4125 Beaumont Rd, Room 250, Lansing, Michigan 48910 8106, USA
J Wildl Dis 45:153-64. 2009..This study demonstrated the capabilities and limitations of several available blood tests for Mycobacterium bovis on specimens obtained through a variety of field surveillance methods...
- Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosisElma Z Tchilian
The Jenner Institute, Oxford University, ORCRB, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom
Infect Immun 77:622-31. 2009..of tuberculosis (TB) in populations coinfected with human immunodeficiency virus, and the failure of Mycobacterium bovis bacillus Calmette-Guerin (BCG) to protect against disease, new vaccines against TB are urgently needed...
- Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responsesMark J Cayabyab
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 83:5505-13. 2009..We successfully generated recombinant Mycobacterium bovis BCG (rBCG) expressing simian immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors,..
- The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary disseminationK Pethe
Unité INSERM U447, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille cedex, France
Nature 412:190-4. 2001..tuberculosis has been identified to date. Here we show that the disruption of the M. tuberculosis or Mycobacterium bovis Bacille Calmette-Guérin (BCG) hbhA gene encoding the heparin-binding haemagglutinin adhesin (HBHA) ..
- Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guérin (BCG) Tokyo 172: a comparative study of BCG vaccine substrainsMasaaki Seki
Japan BCG Laboratory, Research of Product, 3 1 5 Matsuyama, Kiyose City, Tokyo 204 0022, Japan
Vaccine 27:1710-6. 2009..the molecular characteristics of bacillus Calmette-Guérin (BCG) vaccines, the complete genomic sequence of Mycobacterium bovis BCG Tokyo 172 was determined, and the results were compared with those for BCG Pasteur and other M...
- Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1Y Moriwaki
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537, Japan
J Biol Chem 276:23065-76. 2001..By using the differential display approach, we identified a Mycobacterium bovis BCG cell wall skeleton (BCG-CWS)-inducible gene fragment from human monocytes, showing no homology to any ..
- Impairment of mycobacterial immunity in human interleukin-12 receptor deficiencyF Altare
INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
Science 280:1432-5. 1998..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
- Early antibody responses to experimental Mycobacterium bovis infection of cattleW R Waters
Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
Clin Vaccine Immunol 13:648-54. 2006..Sequential serum samples obtained from Mycobacterium bovis-infected cattle were evaluated for seroreactivity to mycobacterial antigens. Animals received M...
- Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organismR Glyn Hewinson
TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 112:127-39. 2006Significant and rapid progress has been made in our knowledge and understanding of Mycobacterium bovis since the last international M. bovis conference 5 years ago...
- Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophagesMichel Denis
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Tuberculosis (Edinb) 87:53-62. 2007..bovis growth in infected macrophages by an unclear mechanism, and are potentially involved in innate resistance of cattle to tuberculosis...
- Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferonTeresa M Wozniak
Centenary Institute, Newtown, NSW, Australia
Infect Immun 78:4187-94. 2010..Therefore, Th17 cells can provide IFN-γ-independent protection against M. tuberculosis, and this effect may contribute to the early control of M. tuberculosis infection...
- Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosisLihao Chen
Infectious Diseases Division, Center for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
Infect Immun 72:238-46. 2004Whether the intranasal (i.n.) route of Mycobacterium bovis BCG vaccination provides better protection against pulmonary tuberculosis than subcutaneous (s.c.) vaccination remains an incompletely solved issue...
- Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reservesA L Michel
ARC Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa
Vet Microbiol 133:335-43. 2009..The molecular characterisation of 189 Mycobacterium bovis isolates from nine wildlife species in the HiP, including three smaller associated parks, and the Kruger ..
- Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptorsS Tsuji
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
Infect Immun 68:6883-90. 2000..In this study, we demonstrated that the cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin (BCG-CWS), a purified noninfectious material consisting of peptidoglycan, ..
- Identification of a heparin-binding hemagglutinin present in mycobacteriaF D Menozzi
Laboratoire de Microbiologie Genetique et Moléculare, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, France
J Exp Med 184:993-1001. 1996..chromatography, a 28-kD heparin-binding protein was purified from culture supernatants and cell extracts of Mycobacterium bovis and Mycobacterium tuberculosis...
- Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattleH M Vordermeier
TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
Clin Diagn Lab Immunol 8:571-8. 2001..scientific review for the government has concluded that the development of a cattle vaccine against Mycobacterium bovis infection holds the best long-term prospect for tuberculosis control in British herds...
- Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattleClare Whelan
Enfer Scientific, Unit T, M7 Business Park, Newhall, Naas, County Kildare, Ireland
Clin Vaccine Immunol 15:1834-8. 2008..system and analyzed with a macro program that tracks each serum for its pattern of antibody activity for Mycobacterium bovis antigens...
- Estimating the true prevalence of Mycobacterium bovis in hunter-harvested white-tailed deer in MichiganDaniel J O'Brien
Rose Lake Wildlife Disease Laboratory, Michigan Department of Natural Resources, 8562 E Stoll Rd, East Lansing, Michigan 48823, USA
J Wildl Dis 40:42-52. 2004..In Michigan, the ability to estimate the true prevalence of bovine tuberculosis (TB; caused by Mycobacterium bovis) in free-ranging white-tailed deer (Odocoileus virginianus) will become increasingly important to ..
- Mycobacterium caprae in cattle and humans in CroatiaZ Cvetnic
Croatian Veterinary Institute Zagreb, Zagreb, Croatia
Int J Tuberc Lung Dis 11:652-8. 2007..The children came from a family that ran a small-sized cattle dairy farm...
- Infection of Acanthamoeba castellanii with Mycobacterium bovis and M. bovis BCG and survival of M. bovis within the amoebaeStephanie J Taylor
Microbial Sciences Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
Appl Environ Microbiol 69:4316-9. 2003Survival of Mycobacterium bovis after ingestion by protozoa would provide an environmental reservoir for infection of cattle. We have shown that M. bovis survived ingestion by Acanthamoeba castellanii. In contrast, two strains of M...
- Oral delivery of lipid-encapsulated Mycobacterium bovis BCG extends survival of the bacillus in vivo and induces a long-term protective immune response against tuberculosisF E Aldwell
Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
Vaccine 24:2071-8. 2006The success of oral-route vaccination using Mycobacterium bovis bacille Calmette-Guérin (BCG) relies on delivery of live, actively metabolising bacilli to confer protection...
- TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infectionAnna Zganiacz
Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Clin Invest 113:401-13. 2004..Our study thus identifies TNF-alpha as a type 1 immunoregulatory cytokine whose primary role, different from those of other type 1 cytokines, is to keep an otherwise detrimental type 1 immune response in check...
- Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovisLeigh A L Corner
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Tuberculosis (Edinb) 88:601-9. 2008b>Mycobacterium bovis is endemic in badger (Meles meles) populations of Ireland and the United Kingdom and infected badgers are a potential source of infection for cattle...
- Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam) assayE Gormley
Large Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Vet Microbiol 112:171-9. 2006..use of the gamma-interferon (IFN-gamma) assay (Bovigam) can provide a means for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal from an infected herd...
- Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccinationDavid K Flaherty
Department of Internal Medicine, Division of Infectious Diseases, Center for Microbial Interface Biology, 420 West 12th Avenue, Columbus, OH 43210, USA
J Leukoc Biol 80:1262-71. 2006b>Mycobacterium bovis bacille Calmette Guerin (BCG), the current vaccine against infection with Mycobacterium tuberculosis, offers a variable, protective efficacy in man...
- Investigation of the transmission of Mycobacterium bovis from deer to cattle through indirect contactMitchell V Palmer
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, 2300 Dayton Ave, Ames, IA 50010, USA
Am J Vet Res 65:1483-9. 2004OBJECTIVE: To investigate the infection of calves with Mycobacterium bovis through oral exposure and transmission of M. bovis from experimentally infected white-tailed deer to uninfected cattle through indirect contact...
- Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004-2007E Rodriguez
National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Int J Tuberc Lung Dis 13:1536-41. 2009To identify the characteristics associated with human tuberculosis (TB) caused by Mycobacterium bovis and M. caprae in Spain.
- Oral vaccination of badgers (Meles meles) with BCG and protective immunity against endobronchial challenge with Mycobacterium bovisLeigh A L Corner
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Vaccine 28:6265-72. 2010Eurasian badgers (Meles meles) are a reservoir host of Mycobacterium bovis and are implicated in the transmission of tuberculosis to cattle in Ireland and Great Britain...
- Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis in Eurasian wild boar (Sus scrofa scrofa)Mariana Boadella
IREC National Wildlife Research Institute CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
J Vet Diagn Invest 23:77-83. 2011..Two hundred sera from wild boar of known Mycobacterium bovis infection status were used to evaluate test suitability for the detection of antibodies against M...
- Tuberculosis immunity: opportunities from studies with cattleW Ray Waters
National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
Clin Dev Immunol 2011:768542. 2011..Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals...
- Identification of a Mycobacterium bovis BCG 45/47-kilodalton antigen complex, an immunodominant target for antibody response after immunization with living bacteriaF Romain
Unité de Physiopathologie de l Infection, Institut Pasteur, Paris, France
Infect Immun 61:742-50. 1993..tuberculosis is induced mainly by a previous immunization with living avirulent mycobacteria, usually Mycobacterium bovis BCG...
- Molecular typing of Mycobacterium bovis strains isolated in Italy from 2000 to 2006 and evaluation of variable-number tandem repeats for geographically optimized genotypingM Beatrice Boniotti
Centro Nazionale di Referenza per la Tubercolosi Bovina, Istituto Zooprofilattico Sperimentale Lombardia e Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy
J Clin Microbiol 47:636-44. 2009Spoligotyping and exact tandem repeat (ETR) analysis of Mycobacterium bovis and M...
- Mycobacterium bovis infection in the Eurasian badger (Meles meles): the disease, pathogenesis, epidemiology and controlL A L Corner
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
J Comp Pathol 144:1-24. 2011Eurasian badgers (Meles meles) are an important wildlife reservoir of tuberculosis (Mycobacterium bovis) infection in Ireland and the United Kingdom...
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisA Banerjee
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
Science 263:227-30. 1994..These results suggest that InhA is likely a primary target of action for INH and ETH...
- Early response of bovine alveolar macrophages to infection with live and heat-killed Mycobacterium bovisStephanie Widdison
Livestock Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK
Dev Comp Immunol 35:580-91. 2011..role in the immune response to TB and recent studies provide insights into the interactions between Mϕ and Mycobacterium bovis. Here we reveal the early transcriptional response of bovine AlvMϕ to M. bovis infection...
- Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattleMartin Vordermeier
Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 151:8-13. 2011..progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test)...
- Mycobacterium bovis at the animal-human interface: a problem, or not?Anita Luise Michel
Department of Veterinary Tropical Diseases, Faculty of Veterinary Sciences, University of Pretoria, Private Bag X4, Onderstepoort 0110, South Africa
Vet Microbiol 140:371-81. 2010b>Mycobacterium bovis is a pathogen of significant importance in livestock and a wide range of wild animal species worldwide...
- The impact of transcriptomics on the fight against tuberculosis: focus on biomarkers, BCG vaccination, and immunotherapyCarlos Rodrigo Zarate-Blades
The Centre for Tuberculosis Research, Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
Clin Dev Immunol 2011:192630. 2011....
- Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countriesLudovic de Beaucoudrey
Laboratory of Human Genetics of Infectious Diseases U980, Institut National de la Sante et de la Recherche Medicale, Paris, France
Medicine (Baltimore) 89:381-402. 2010..The condition has higher clinical penetrance, broader susceptibility to infections, and less favorable outcome than previously thought...
- Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7N R Chu
StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Exp Immunol 121:216-25. 2000..carcinoma, an immunotherapy based on the administration of an adjuvant-free fusion protein comprising Mycobacterium bovis BCG heat shock protein (hsp)65 linked to HPV16 E7 (hspE7) has been developed...
- Mycobacterium bovis with different genotypes and from different hosts induce dissimilar immunopathological lesions in a mouse model of tuberculosisD Aguilar Leon
Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition, Salvador Zubiran, Mexico City, Mexico
Clin Exp Immunol 157:139-47. 2009With the hypothesis that genetic variability of Mycobacterium bovis could influence virulence and immunopathology, five M...
- Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-GuerinManjunatha M Venkataswamy
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY10461, USA
J Immunol 183:1644-56. 2009The attenuated strain of Mycobacterium bovis known as bacille Calmette-Guérin (BCG) has been widely used as a vaccine for prevention of disease by Mycobacterium tuberculosis, but with relatively little evidence of success...
- Immunomagnetic recovery of Mycobacterium bovis from naturally infected environmental samplesF P Sweeney
Department of Biological Sciences, University of Warwick, Coventry, UK
Lett Appl Microbiol 43:364-9. 2006To adapt an immunomagnetic capture (IMC) technique to concentrate and cultivate Mycobacterium bovis from environmental samples including soil, faeces and urine.
- Estimating the true prevalence of Mycobacterium bovis in free-ranging elk in MichiganDaniel J O'Brien
Wildlife Disease Laboratory, Michigan Department of Natural Resources, Lansing, Michigan 48910 8106, USA
J Wildl Dis 44:802-10. 2008..Elk and red deer (Cervus elaphus elaphus) are highly susceptible to infection with Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), and outbreaks have been documented worldwide...
- Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activityJanice J Endsley
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, United States
Vaccine 25:8384-94. 2007..used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG)...
- Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosisSylvie Bertholet
Infectious Disease Research Institute, Seattle WA 98104, USA
J Immunol 181:7948-57. 2008..This study identified numerous novel human T cell Ags suitable to be included in subunit vaccines against tuberculosis...
- Molecular detection of Mycobacterium bovis and Mycobacterium bovis BCG (Pasteur) in soilJamie S Young
Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom
Appl Environ Microbiol 71:1946-52. 2005PCR primers specific for the Mycobacterium tuberculosis complex were used to detect the presence of Mycobacterium bovis BCG (Pasteur) in soil microcosms and Mycobacterium bovis in environmental samples taken from a farm in Ireland with a ..
- Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophagesJanice J Endsley
Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
J Leukoc Biol 79:71-9. 2006..of granulysin, interferon-gamma, and perforin and have cytotoxic activity against human tumor cells and Mycobacterium bovis bacillus Calmette-Guerin-infected alveolar and monocyte-derived macrophages...
- The influence of remaining live BCG organisms in vaccinated mice on the maintenance of immunity to tuberculosisA W Olsen
Department of Infectious Disease Immunology Statens Serum Institut Copenhagen, Denmark
Scand J Immunol 60:273-7. 2004..The implications for comparing BCG vaccination with experimental vaccines including non-replicating vaccines are discussed...
- Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signalsSally J Price
Institute for Animal Health, Compton, Newbury, Berkshire, UK
Immunology 126:201-8. 2009Evidence suggests that gammadelta T cells form part of the innate immune response to Mycobacterium bovis infection...
- A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strainsM Carmen Garcia Pelayo
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Dublin 4, Ireland
Infect Immun 77:2230-8. 2009To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to identify single nucleotide polymorphisms (SNPs) that differed between sequenced strains ..
- Risk factors associated with bovine tuberculosis in traditional cattle of the livestock/wildlife interface areas in the Kafue basin of ZambiaM Munyeme
Department of Disease Control, University of Zambia, School of Veterinary Medicine, P O Box 32379, Lusaka, Zambia
Prev Vet Med 85:317-28. 2008..0) of being positive compared to sedentary herds (OR=1.0). The results in this study provide preliminary information about potential risk factors that were found to be associated with BTB status in cattle...
- Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivoSanchita Bhatnagar
Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
Blood 110:3234-44. 2007....
- Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cellsM J Brennan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 69:7326-33. 2001..In this study, we demonstrate that a transposon insertion in a PE_PGRS gene (1818(PE_PGRS)) found in Mycobacterium bovis BCG Pasteur, which is the BCG homologue of the M...
- Tuberculosis from Mycobacterium bovis in binational communities, United StatesTimothy C Rodwell
University of California San Diego School of Medicine, La Jolla, California 92093 0622, USA
Emerg Infect Dis 14:909-16. 2008..b>Mycobacterium bovis appears to be contributing substantially to the TB incidence in some binational communities with ties to ..
- Coadministration of interleukins 7 and 15 with bacille Calmette-Guérin mounts enduring T cell memory response against Mycobacterium tuberculosisVijender Singh
Institute of Microbial Technology, Chandigarh, India
J Infect Dis 202:480-9. 2010..This may be due to its failure to induce long-lasting memory T cells. T cell memory is dependent on crucial cytokine signals during the priming phases. Therefore, coadministering the BCG vaccine with cytokines may improve its efficacy...
- Exposure of cord blood to Mycobacterium bovis BCG induces an innate response but not a T-cell cytokine responseM L V Watkins
Division of Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Clin Vaccine Immunol 15:1666-73. 2008Despite routine vaccination with Mycobacterium bovis bacillus Calmette-Guérin (BCG) soon after birth, tuberculosis in babies and adults remains epidemic in South Africa...
- Pathology of Mycobacterium bovis infection in wild meerkats (Suricata suricatta)J A Drewe
Wildlife Health and Conservation Medicine Group, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
J Comp Pathol 140:12-24. 2009Pathological lesions associated with Mycobacterium bovis infection (bovine tuberculosis; bTB) in free-living meerkats (Suricata suricatta) in the Kalahari Desert of South Africa are described...
- Immunological responses and protective immunity in BCG vaccinated badgers following endobronchial infection with Mycobacterium bovisSandrine Lesellier
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Vaccine 27:402-9. 2009European badgers (Meles meles) are a reservoir host of Mycobacterium bovis and are implicated in the transmission of tuberculosis to cattle in Ireland and Great Britain...
- Culling and cattle controls influence tuberculosis risk for badgersRosie Woodroffe
Department of Wildlife, Fish, and Conservation Biology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 103:14713-7. 2006..In Britain, European badgers (Meles meles) are implicated in transmitting Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), to cattle...
- Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lungRuchi Jain
Department of Biochemistry, University of Delhi South Campus, New Delhi, India
PLoS ONE 3:e3869. 2008The variable efficacy (0-80%) of Mycobacterium bovis Bacille Calmette Guréin (BCG) vaccine against adult tuberculosis (TB) necessitates development of alternative vaccine candidates...
- Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routesT McCorry
Department of Veterinary Science, Queen's University of Belfast, Stoney Road, Stormont
Vet Rec 157:613-8. 2005..a low dose of approximately 10(4) colony-forming units (cfu) or a high dose of approximately 10(6) cfu of Mycobacterium bovis. Each dose was delivered by the intranasal and intratracheal routes...
- Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1Charles F Capinos Scherer
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
Transbound Emerg Dis 56:228-39. 2009..In the present study, we examined the kinetics of granulysin, perforin, IFNgamma and Fas-L responses to Mycobacterium bovis purified protein derivative (PPD) stimulation by peripheral blood mononuclear cells from M...
- Environmental monitoring of Mycobacterium bovis in badger feces and badger sett soil by real-time PCR, as confirmed by immunofluorescence, immunocapture, and cultivationF P Sweeney
Microbiology Group, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Appl Environ Microbiol 73:7471-3. 2007Real-time PCR was used to detect and quantify Mycobacterium bovis cells in naturally infected soil and badger feces. Immunomagnetic capture, immunofluorescence, and selective culture confirmed species identification and cell viability...
- Vaccine platform for prevention of tuberculosis and mother-to-child transmission of human immunodeficiency virus type 1 through breastfeedingEung Jun Im
Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, Oxford OX3 9DS, United Kingdom
J Virol 81:9408-18. 2007..Here, a recombinant lysine auxotroph of Mycobacterium bovis bacillus Calmette-Guérin (BCG), a BCG strain that is safer than those currently used and expresses an ..
- Ruptured mycotic abdominal aortic aneurysm secondary to Mycobacterium bovis after intravesical treatment with bacillus Calmette-GuérinGregory E J Harding
Division of Vascular Surgery, London Health Sciences Centre and University of Western Ontario, 800 Commissioners Road E, London, Ontario, Canada
J Vasc Surg 46:131-4. 2007Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has proven effective in the treatment of early-stage bladder cancer...
- Use of non-invasive bioluminescent imaging to assess mycobacterial dissemination in mice, treatment with bactericidal drugs and protective immunityFrank Heuts
Department of Microbiology, Karolinska Institute, Box 280, 17177 Stockholm, Sweden
Microbes Infect 11:1114-21. 2009..Here, we describe for the first time and validate the use of a luciferase-tagged recombinant Mycobacterium bovis BCG for non-invasive bioluminescent imaging of 1) bacterial dissemination in tissues, 2) the efficacy of ..
- Human tuberculosis caused by Mycobacterium bovis in the United States, Latin America and the CaribbeanI N de Kantor
World Health Organization TB Consultants Group, Buenos Aires, Argentina
Int J Tuberc Lung Dis 14:1369-73. 2010Human tuberculosis (TB) caused by Mycobacterium bovis appears to be rare in most of the region of the Americas, although some localities have reported an unusually high prevalence of M. bovis among human TB cases (e.g...
- Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein familyGareth J Jones
TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Infect Immun 78:1326-32. 2010..experiments revealed that secreted proteins are among the most frequently recognized antigens from Mycobacterium bovis. Thus, we hypothesized that the analysis of secreted proteins is likely to reveal additional immunogenic ..
- Surveillance of coyotes to detect bovine tuberculosis, MichiganKurt C VerCauteren
US Department of Agriculture, Animal and Plant Health Inspection Service Wildlife Services, Fort Collins, Colorado 80521, USA
Emerg Infect Dis 14:1862-9. 2008..Surveillance identified coyotes (Canis latrans) as potential bio-accumulators of Mycobacterium bovis, a finding that generated interest in their potential to serve as sentinels for monitoring disease risk...
- THP-1 cell apoptosis in response to Mycobacterial infectionCarrie J Riendeau
Department of Pathology and Laboratory Medicine. Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Infect Immun 71:254-9. 2003..Consistent with the behavior of alveolar macrophages, attenuated M. tuberculosis H37Ra and Mycobacterium bovis BCG strongly induce THP-1 apoptosis, which requires endogenous TNF...
- Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native stateBenoit Zuber
Laboratory of Ultrastructural Analysis, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland
J Bacteriol 190:5672-80. 2008..a detailed ultrastructural analysis of three species belonging to the Corynebacterineae suborder, namely, Mycobacterium bovis BCG, Mycobacterium smegmatis, and Corynebacterium glutamicum, in their native state...
- Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-gamma-stimulated JAK/STAT signaling in J774 macrophagesKenichi Imai
Department of Oral Microbiology, Meikai University, School of Dentistry, Keyakidai, Sakado shi, 350 0283, Saitama, Japan
FEMS Immunol Med Microbiol 39:173-80. 2003..b>Mycobacterium bovis bacillus Calmette-Guérin infection induces the production of SOCS-1 and SOCS-3 in murine J774 macrophages...
- Vaccinating badgers (Meles meles) against Mycobacterium bovis: the ecological considerationsR J Delahay
Wildlife Disease Ecology Team, Central Science Laboratory, York, YO41 1LZ, Sand Hutton, UK
Vet J 166:43-51. 2003..Meles meles) is widely considered to represent a significant wildlife reservoir for the transmission of Mycobacterium bovis to cattle, and has been the subject of a variety of culling strategies since the mid 1970s...
- Epidemiology of Mycobacterium bovis in free-ranging white-tailed deer, Michigan, USA, 1995-2000Daniel J O'Brien
Rose Lake Wildlife Disease Laboratory, Wildlife Division, Michigan Department of Natural Resources, 8562 E Stoll Road, East Lansing, MI 48823 9454, USA
Prev Vet Med 54:47-63. 2002An endemic area of bovine tuberculosis (TB) (Mycobacterium bovis) currently affecting wild white-tailed deer (Odocoileus virginianus) in northern lower Michigan, USA, constitutes the first self-sustaining outbreak of the infection in ..
- Development of vaccines to control bovine tuberculosis in cattle and relationship to vaccine development for other intracellular pathogensBryce M Buddle
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Int J Parasitol 33:555-66. 2003..could be an important strategy for the control of disease either where there is a wildlife reservoir of Mycobacterium bovis infection or in developing countries where it is not economically feasible to implement a 'test and ..
- Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient miceM Jacobs
Department of Immunology, University of Cape Town, Cape Town, South Africa
Clin Immunol 94:192-9. 2000Neutralization of TNF or disruption of TNF-R1 leads to fatal Mycobacterium bovis BCG infection...
- Prospects for new vaccines against tuberculosisLise Brandt
Colorado State University, Fort Collins, USA
Biotechniques 33:1098, 1100, 1102. 2002
- Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adultsGillian F Black
Karonga Prevention Study, Chilumba, Malawi
Clin Diagn Lab Immunol 10:602-11. 2003..tuberculosis antigens tested it provided the best indication of exposure to, or infection with, M. tuberculosis...
- Immune response and protection by DNA vaccines expressing antigen 85B of Mycobacterium tuberculosisManuela Pardini
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanit, Rome, Italy
FEMS Microbiol Lett 262:210-5. 2006..97 log10 CFU decrease). Multipromoter plasmids, which permit the reduction of the total amount of DNA injected, can be useful for DNA vaccination against tuberculosis...
- Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovisNoel H Smith
Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, KT15 3NB UK
Nat Rev Microbiol 4:670-81. 2006b>Mycobacterium bovis is the cause of tuberculosis in cattle and is a member of the Mycobacterium tuberculosis complex...
- DNA vaccine using Mycobacterium bovis Ag85B antigen induces partial protection against experimental infection in BALB/c miceFrancisco M Teixeira
Laboratory of Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Minas Gerais, Brazil
Clin Vaccine Immunol 13:930-5. 2006..The main goal of this study was to test the Mycobacterium bovis Ag85B gene as a DNA vaccine following challenge with an M. bovis virulent strain (ATCC 19274)...
- Effect of different adjuvants on the immune responses of cattle vaccinated with Mycobacterium tuberculosis culture filtrate proteinsD N Wedlock
AgResearch Ltd, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Vet Immunol Immunopathol 86:79-88. 2002....
- Immunogenicity of Mycobacterium tuberculosis antigens in Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattleA S Mustafa
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat
Infect Immun 74:4566-72. 2006The development of novel vaccine strategies supplementing Mycobacterium bovis BCG (BCG) constitutes an urgent research challenge...
- CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATIONStephen W Chensue; Fiscal Year: 2010..This hypothesis will be tested under conditions of Mycobacterium bovis and Schistosoma mansoni exposure by way of the following aims...
- M Tuberculosis CTL Epitopes: Vaccine Design/EvaluationCarol Clayberger; Fiscal Year: 2003..b>Mycobacterium bovis Bacille Calmette-Guerin (BCG), the current anti-TB vaccine, is quite variable in its ability to protect ..
- M Tuberculosis CTL Epitopes: Vaccine Design/EvaluationCarol Clayberger; Fiscal Year: 2006..b>Mycobacterium bovis Bacille Calmette-Guerin (BCG), the current anti-TB vaccine, is quite variable in its ability to protect ..
- DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICIENCYDavid McMurray; Fiscal Year: 1999..will be applied in experiments which are designed to address the following specific aims: (1) To utilize Mycobacterium bovis BCG and attenuated Mycobacterium tuberculosis H37Ra in order to establish the importance of homology ..
- A Novel Oral Combination Pediatric HIV and TB VaccineMichelle H Larsen; Fiscal Year: 2010..However, for obvious safety reasons, live attenuated HIV vaccination is not feasible. Mycobacterium bovis bacilli Calmette-Guerin (BCG) vaccination induces strong T helper 1 (Th1) responses in human infants...
- Gene Therapy for the Wiskott Aldrich SyndromeTED STROM; Fiscal Year: 2007..The applicant's preliminary data have established sensitivity to challenge with mycobacterium bovis and influenza in the murine WAS model providing quantifiable assays for evaluating the effects of gene ..
- Role of WhiB3 in M. tuberculosis virulenceADRIE STEYN; Fiscal Year: 2007..2 domain of RpoV, the principal sigma factor in Mycobacterium bovis, is attenuating. Using the yeast two-hybrid system, we have established that the 4...
- The Role of SP-A in Pulmonary Host DefenseVIRGINIA SHEPHERD; Fiscal Year: 2004..We have shown in preliminary studies that Mycobacterium bovis BCG and Mycobacterium avium internalization by macrophages is enhanced by opsonization with SP-A...
- MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGENCarl Nathan; Fiscal Year: 2003..We will focus first on AhpC, recently shown to be a virulence factor for Mycobacterium bovis, and analyze the impact of mutations, its biochemical mechanism and its expression in Mtb...
- Unraveling the Molecular Mechanisms of Phagocytosis(RMI)Fabienne Paumet; Fiscal Year: 2005..infectious disease is tuberculosis caused by mycobacterium tuberculosis (and to much lesser extent mycobacterium bovis). M...
- Mechanisms of Regulation of Autoimmune Th1 CD4 T cellsDYANA DALTON; Fiscal Year: 2006..IFN-gamma and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
- Mechanisms of Regulation of Autoimmune Th1 CD4 T cellsDYANA DALTON; Fiscal Year: 2007..IFN-y and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
- SP-A Receptor Modulation of Macrophage PhagocytosisZissis Chroneos; Fiscal Year: 2004..To facilitate these studies we will utilize immature alveolar macrophages that we have isolated, and Mycobacterium bovis BCG and Mycobacterium tuberculosis Ra reporter strains that express green fluorescent protein...
- Mechanisms of Regulation of Autoimmune Th1 CD4 T cellsDYANA DALTON; Fiscal Year: 2003..IFN-gamma and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
- Nonpathogenic Mycobacteria:Anti-Bladder Tumor TherapyGlenn Fennelly; Fiscal Year: 2005..In particular, we will study the efficacy of wild type Mycobacterium smegmatis, and Mycobacterium bovis BCG, or alternative modified mycobacteria, for the delivery of genes that express functional cytokines or ..
- T Cell- Mediated Immunity to Mycobacterial InfectionMatthew Williams; Fiscal Year: 2005..In contrast, Mycobacterium bovis bacillus Calmette-Guerin (BCG) persists in the face of detectable CD4 and CD8 T cell responses, with much ..