Genomes and Genes
Summary: The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Publications308 found, 100 shown here
- Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniquesR de la Rua-Domenech
Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
Res Vet Sci 81:190-210. 2006..Tests of humoral (antibody) immunity, Mycobacterium bovis PCR probes on early tissue cultures or live cattle specimens, and tests based on "electronic nose" ..
- Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in miceEmily K Forbes
The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
J Immunol 181:4955-64. 2008..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
- Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lungYuko Okamoto Yoshida
Tropical Biosphere Research Center, Division of Host Defense and Vaccinology, Department of Microbiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
J Immunol 184:4414-22. 2010..Therefore, IL-17A gene-knockout (KO) mice fail to develop mature granulomas in the Mycobacterium bovis bacille Calmette-Guérin (BCG)-infected lung...
- Mycobacterium tuberculosis: here today, and here tomorrowD G Russell
Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
Nat Rev Mol Cell Biol 2:569-77. 2001..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control...
- B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infectionRicardo T Russo
Discipline of Immunology, Department of Microbiology, Immunology, and Parasitology, Universidade Federal de Sao Paulo, Brazil
Immunobiology 215:1005-14. 2010..cultured B-1 cells, we investigated the influence of these cells on some of the immune events triggered by Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice...
- Neutrophil-mediated innate immune resistance to mycobacteriaAdrian R Martineau
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
J Clin Invest 117:1988-94. 2007..The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3...
- Multiple defects of immune cell function in mice with disrupted interferon-gamma genesD K Dalton
Genentech Inc, South San Francisco, CA 94080
Science 259:1739-42. 1993..IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen...
- Mycobacterium bovis at the animal-human interface: a problem, or not?Anita Luise Michel
Department of Veterinary Tropical Diseases, Faculty of Veterinary Sciences, University of Pretoria, Private Bag X4, Onderstepoort 0110, South Africa
Vet Microbiol 140:371-81. 2010b>Mycobacterium bovis is a pathogen of significant importance in livestock and a wide range of wild animal species worldwide...
- Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosisFlorian Winau
Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
Immunity 24:105-17. 2006..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...
- The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: how to assess the riskL A L Corner
Department of Large Animal Clinical Studies, University College Dublin, Dublin, Ireland
Vet Microbiol 112:303-12. 2006..A detailed analysis of Mycobacterium bovis infection in the Eurasian badger (Meles meles) in Ireland and their role as a reservoir of infection for ..
- Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in miceBo Young Jeon
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 76:5173-80. 2008..certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity...
- Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycanJunji Uehori
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
Infect Immun 71:4238-49. 2003The Mycobacterium bovis bacillus Calmette-Guérin (BCG) cell wall skeleton (CWS) consists of mycolic acids, arabinogalactan, and peptidoglycan (PGN) and activates Toll-like receptor 2 (TLR2) and TLR4...
- Gene expression profiling of the host response to Mycobacterium bovis infection in cattleD E MacHugh
Animal Genomics Laboratory, UCD School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Dublin, Ireland
Transbound Emerg Dis 56:204-14. 2009Bovine tuberculosis (BTB), caused by Mycobacterium bovis, continues to pose a threat to livestock worldwide and, as a zoonotic infection, also has serious implications for human health...
- Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillusA Scorpio
Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Nat Med 2:662-7. 1996Naturally pyrazinamide (PZA)-resistant Mycobacterium bovis and acquired PZA-resistant M. tuberculosis strains lose pyrazinamidase (PZase)...
- Impairment of mycobacterial immunity in human interleukin-12 receptor deficiencyF Altare
INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
Science 280:1432-5. 1998..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
- Positive and negative effects of widespread badger culling on tuberculosis in cattleChristl A Donnelly
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Nature 439:843-6. 2006..Meles meles) have been culled by the British government in a series of attempts to limit the spread of Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), to cattle...
- Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1Y Moriwaki
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537, Japan
J Biol Chem 276:23065-76. 2001..By using the differential display approach, we identified a Mycobacterium bovis BCG cell wall skeleton (BCG-CWS)-inducible gene fragment from human monocytes, showing no homology to any ..
- Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatisJeanne M DiChiara
Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201 2002, USA
Nucleic Acids Res 38:4067-78. 2010..tuberculosis could be functioning in mediation of virulence, thus rendering them potential targets for novel antimycobacterials. Various features and regulatory aspects of some of these sRNAs are discussed...
- The duration of the effects of repeated widespread badger culling on cattle tuberculosis following the cessation of cullingHelen E Jenkins
Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS ONE 5:e9090. 2010..However, a full assessment of the utility of badger culling requires information on the duration of culling effects...
- Evidence of genetic resistance of cattle to infection with Mycobacterium bovisS Brotherstone
School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
J Dairy Sci 93:1234-42. 2010Anecdotal evidence points to genetic variation in resistance of cattle to infection with Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), and published experimental evidence in deer and cattle suggests significant ..
- TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infectionAnna Zganiacz
Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Clin Invest 113:401-13. 2004..Our study thus identifies TNF-alpha as a type 1 immunoregulatory cytokine whose primary role, different from those of other type 1 cytokines, is to keep an otherwise detrimental type 1 immune response in check...
- Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophagesHeloisa D'Avila
Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
Cell Microbiol 10:2589-604. 2008..The uptake of apoptotic neutrophils by macrophages leads to TGF-beta1 generation and PGE(2)-derived lipid body formation, and may have modulator roles in mycobacterial pathogenesis...
- Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosisH Martin Vordermeier
Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Infect Immun 70:3026-32. 2002..To address these questions, cattle were vaccinated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) and were then challenged with virulent M. bovis...
- A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosisPuiying A Mak
Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, United States
ACS Chem Biol 7:1190-7. 2012..Approximately 800 compounds were confirmed to reduce intracellular ATP levels in a dose-dependent manner in Mycobacterium bovis BCG. One hundred and forty non-cytotoxic compounds with activity against hypoxic non-replicating M...
- Mycobacterium bovis infection in the Eurasian badger (Meles meles): the disease, pathogenesis, epidemiology and controlL A L Corner
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
J Comp Pathol 144:1-24. 2011Eurasian badgers (Meles meles) are an important wildlife reservoir of tuberculosis (Mycobacterium bovis) infection in Ireland and the United Kingdom...
- Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesisPatricia E Almeida
Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
J Immunol 183:1337-45. 2009..the molecular mechanisms underlying the formation of macrophage lipid bodies (lipid droplets) during Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, focusing on the role of the lipid-activated nuclear receptor ..
- Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivoHeloisa D'Avila
Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
J Immunol 176:3087-97. 2006..b>Mycobacterium bovis bacillus Calmette-Guérin (BCG), but not Mycobacterium smegmatis, induced a dose- and time-dependent ..
- Recurrence of bovine tuberculosis breakdowns in Great Britain: risk factors and predictionK Karolemeas
Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, CB3 0ES, UK
Prev Vet Med 102:22-9. 2011..These variables are indicative of a higher level of infection or residual infection, and could be useful in the future development of predictive models for bTB recurrence...
- Mycobacterium tuberculosis infection in grazing cattle in central EthiopiaGobena Ameni
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
Vet J 188:359-61. 2011..bovis. The practice of local farmers discharging chewed tobacco directly into the mouths of pastured cattle was identified as a potential route of human-to-cattle transmission of M. tuberculosis...
- Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responsesMark J Cayabyab
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 83:5505-13. 2009..We successfully generated recombinant Mycobacterium bovis BCG (rBCG) expressing simian immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors,..
- Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guérin (BCG) Tokyo 172: a comparative study of BCG vaccine substrainsMasaaki Seki
Japan BCG Laboratory, Research of Product, 3 1 5 Matsuyama, Kiyose City, Tokyo 204 0022, Japan
Vaccine 27:1710-6. 2009..the molecular characteristics of bacillus Calmette-Guérin (BCG) vaccines, the complete genomic sequence of Mycobacterium bovis BCG Tokyo 172 was determined, and the results were compared with those for BCG Pasteur and other M...
- Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosisElma Z Tchilian
The Jenner Institute, Oxford University, ORCRB, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom
Infect Immun 77:622-31. 2009..of tuberculosis (TB) in populations coinfected with human immunodeficiency virus, and the failure of Mycobacterium bovis bacillus Calmette-Guerin (BCG) to protect against disease, new vaccines against TB are urgently needed...
- Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosisLihao Chen
Infectious Diseases Division, Center for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
Infect Immun 72:238-46. 2004Whether the intranasal (i.n.) route of Mycobacterium bovis BCG vaccination provides better protection against pulmonary tuberculosis than subcutaneous (s.c.) vaccination remains an incompletely solved issue...
- The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary disseminationK Pethe
Unité INSERM U447, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille cedex, France
Nature 412:190-4. 2001..tuberculosis has been identified to date. Here we show that the disruption of the M. tuberculosis or Mycobacterium bovis Bacille Calmette-Guérin (BCG) hbhA gene encoding the heparin-binding haemagglutinin adhesin (HBHA) ..
- Survival of Mycobacterium bovis on feedstuffs commonly used as supplemental feed for white-tailed deer (Odocoileus virginianus)Mitchell V Palmer
United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa, USA
J Wildl Dis 42:853-8. 2006b>Mycobacterium bovis, the causative agent of bovine tuberculosis, has become established in free-ranging white-tailed deer Odocoileus virginianus in northeastern Michigan...
- Early antibody responses to experimental Mycobacterium bovis infection of cattleW R Waters
Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
Clin Vaccine Immunol 13:648-54. 2006..Sequential serum samples obtained from Mycobacterium bovis-infected cattle were evaluated for seroreactivity to mycobacterial antigens. Animals received M...
- Evaluation of blood assays for detection of Mycobacterium bovis in white-tailed deer (Odocoileus virginianus) in MichiganDaniel J O'Brien
Wildlife Disease Laboratory, Michigan Department of Natural Resources, 4125 Beaumont Rd, Room 250, Lansing, Michigan 48910 8106, USA
J Wildl Dis 45:153-64. 2009..This study demonstrated the capabilities and limitations of several available blood tests for Mycobacterium bovis on specimens obtained through a variety of field surveillance methods...
- Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organismR Glyn Hewinson
TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 112:127-39. 2006Significant and rapid progress has been made in our knowledge and understanding of Mycobacterium bovis since the last international M. bovis conference 5 years ago...
- Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophagesMichel Denis
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Tuberculosis (Edinb) 87:53-62. 2007..bovis growth in infected macrophages by an unclear mechanism, and are potentially involved in innate resistance of cattle to tuberculosis...
- Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptorsS Tsuji
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
Infect Immun 68:6883-90. 2000..In this study, we demonstrated that the cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin (BCG-CWS), a purified noninfectious material consisting of peptidoglycan, ..
- Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reservesA L Michel
ARC Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa
Vet Microbiol 133:335-43. 2009..The molecular characterisation of 189 Mycobacterium bovis isolates from nine wildlife species in the HiP, including three smaller associated parks, and the Kruger ..
- Identification of a heparin-binding hemagglutinin present in mycobacteriaF D Menozzi
Laboratoire de Microbiologie Genetique et Moléculare, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, France
J Exp Med 184:993-1001. 1996..chromatography, a 28-kD heparin-binding protein was purified from culture supernatants and cell extracts of Mycobacterium bovis and Mycobacterium tuberculosis...
- Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native stateBenoit Zuber
Laboratory of Ultrastructural Analysis, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland
J Bacteriol 190:5672-80. 2008..a detailed ultrastructural analysis of three species belonging to the Corynebacterineae suborder, namely, Mycobacterium bovis BCG, Mycobacterium smegmatis, and Corynebacterium glutamicum, in their native state...
- Animal-side serologic assay for rapid detection of Mycobacterium bovis infection in multiple species of free-ranging wildlifeK P Lyashchenko
Chembio Diagnostic Systems, Inc, 3661 Horseblock Road, Medford, NY 11763, USA
Vet Microbiol 132:283-92. 2008Numerous species of mammals are susceptible to Mycobacterium bovis, the causative agent of bovine tuberculosis (TB). Several wildlife hosts have emerged as reservoirs of M. bovis infection for domestic livestock in different countries...
- Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferonTeresa M Wozniak
Centenary Institute, Newtown, NSW, Australia
Infect Immun 78:4187-94. 2010..Therefore, Th17 cells can provide IFN-γ-independent protection against M. tuberculosis, and this effect may contribute to the early control of M. tuberculosis infection...
- The transmission of Mycobacterium bovis infection to cattleC J C Phillips
Department of Clinical Veterinary Medicine, University of Cambridge, CB3 0ES, Cambridge, UK
Res Vet Sci 74:1-15. 2003The prevalence of Mycobacterium bovis infection in cattle is increasing rapidly in some countries, including the UK and Ireland...
- Epizootiologic survey of Mycobacterium bovis in wildlife and farm environments in northern MichiganGary Witmer
US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Ave, Fort Collins, Colorado 80521 2154, USA
J Wildl Dis 46:368-78. 2010Bovine tuberculosis (bovine TB), caused by Mycobacterium bovis, has reemerged in northern Michigan, USA, with detections in white-tailed deer (Odocoileus virginianus) in 1994 and in cattle in 1998...
- Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2LTroy J Kemp
Department of Urology, Interdisciplinary Graduate Program in Immunolgy, University of Iowa, Iowa City, 52242, USA
Blood 106:3474-82. 2005b>Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used to treat bladder cancer for almost 30 years; however, the effector mechanism of the BCG-induced antitumor response remains enigmatic...
- The influence of cattle breed on susceptibility to bovine tuberculosis in EthiopiaMartin Vordermeier
Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Comp Immunol Microbiol Infect Dis 35:227-32. 2012....
- Advances in ante-mortem diagnosis of tuberculosis in cattleB M Buddle
AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
N Z Vet J 57:173-80. 2009The tuberculin skin test is effective in the early detection of pre-clinical cases of Mycobacterium bovis infection in cattle...
- Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great BritainR Daniel
Veterinary Laboratories Agency VLA Carmarthen, Job s Well Road, Johnstown, Carmarthen SA31 3EZ
Vet Rec 165:335-42. 2009An outbreak of caprine tuberculosis caused by Mycobacterium bovis was disclosed in June 2008, affecting goats of the golden Guernsey breed kept on 10 separate smallholdings in south-west Wales and the west of England...
- The complete genome sequence of Mycobacterium bovisThierry Garnier
Unité de Génétique Moléculaire Bactérienne and PT4 Annotation, Genopole, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 100:7877-82. 2003b>Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion...
- African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East AfricaStefan Berg
VLA Weybridge, New Haw, Surrey KT15 3NB, United Kingdom
J Bacteriol 193:670-8. 2011We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M...
- Mycobacterium bovis lipids: virulence and vaccinesGrant S Hotter
AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
Vet Microbiol 151:91-8. 2011b>Mycobacterium bovis is an important pathogen of both domesticated and wild animals in many countries, and improved vaccines have great potential to assist in its control and eventual eradication...
- Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovisKelly L Diegel
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
J Wildl Dis 38:275-81. 2002Eight North American opossums (Didelphis virginiana) were inoculated with 1 x 10(5) colony forming units of Mycobacterium bovis to investigate their potential as reservoir hosts for bovine tuberculosis in Michigan...
- Apoptosis-inducing factor participation in bovine macrophage Mycobacterium bovis-induced caspase-independent cell deathX Vega-Manriquez
Departamento de Microbiologia e Inmunologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Circuito exterior s n, Ciudad Universitaria, Coyoacan 04510, Mexico City, Mexico
Infect Immun 75:1223-8. 2007..Previously, our group demonstrated macrophage apoptosis as a consequence of Mycobacterium bovis infection. In this study, we aimed to identify the contribution of apoptotic effector elements in M...
- Bovine tuberculosis in wild boar (Sus scrofa), red deer (Cervus elaphus) and cattle (Bos taurus) in a Mediterranean ecosystem (1992-2004)J Hermoso De Mendoza
Patología Infecciosa, Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain
Prev Vet Med 74:239-47. 2006..It is imperative to investigate the epidemiology of Mycobacterium bovis infection in red deer and wild boar in order to keep a good health status and to maintain the effectiveness ..
- The effects of annual widespread badger culls on cattle tuberculosis following the cessation of cullingHelen E Jenkins
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
Int J Infect Dis 12:457-65. 2008....
- The effect of tuberculin testing on the development of cell-mediated immune responses during Mycobacterium bovis infectionM L Thom
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
Vet Immunol Immunopathol 114:25-36. 2006..effect on CMI responses, groups of 6-month old calves were inoculated intranasally with 8 x 10(4) cfu of Mycobacterium bovis, subjected to the comparative intradermal tuberculin test (TT) using bovine and avian PPD (PPD-B, PPD-A) at ..
- Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populationsNatalie E R Beveridge
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Eur J Immunol 37:3089-100. 2007..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
- IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infectionMasayuki Umemura
Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
J Immunol 178:3786-96. 2007..also in T cell-mediated IFN-gamma production and granuloma formation in response to pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin (BCG)...
- Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selectionVikas Srivastava
Microbiology Division, Central Drug Research Institute, Lucknow, India
Microbiology 153:659-66. 2007..In addition, an M. tuberculosis genomic DNA library was inserted into pLL192 and then introduced into Mycobacterium bovis BCG. The recombinant BCG cells were then used to infect the J774A...
- Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in miceRachel A Moulton
Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center, 6431 Fannin, Houston, TX 77030, USA
J Leukoc Biol 82:956-67. 2007During acquired immunity to Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice, dendritic cells (DCs) present mycobacterial antigens to naive T cells to prime an immune response...
- Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genesKate E Killick
UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 12:611. 2011b>Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact...
- Use of cattle farm resources by badgers (Meles meles) and risk of bovine tuberculosis (Mycobacterium bovis) transmission to cattleB T Garnett
Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
Proc Biol Sci 269:1487-91. 2002..The badgers, which included three individuals infected with bovine tuberculosis (Mycobacterium bovis), used cowsheds, feedsheds, barns, haystacks, slurry pits, cattle troughs and farmyards to exploit a range ..
- Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattleH M Vordermeier
TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
Clin Diagn Lab Immunol 8:571-8. 2001..scientific review for the government has concluded that the development of a cattle vaccine against Mycobacterium bovis infection holds the best long-term prospect for tuberculosis control in British herds...
- Analysis of the spatial variation of Bovine tuberculosis disease risk in Spain (2006-2009)A Allepuz
Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Prev Vet Med 100:44-52. 2011..This study has identified some specific areas of increased BTB risk in Spain, information that is useful for disease management...
- Management of bovine tuberculosis in Michigan wildlife: current status and near term prospectsDaniel J O'Brien
Wildlife Disease Laboratory, Michigan Department of Natural Resources, 4125 Beaumont Road, Lansing, MI 48910 8106, USA
Vet Microbiol 151:179-87. 2011..Yet formidable challenges remain, and evidence suggests that eradication of bTB, if it can be achieved, will take decades, and will require greater public and political resolve than has been demonstrated thus far...
- Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 miceS A Fulton
Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984, USA
Infect Immun 70:5322-7. 2002..In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs...
- Fine-tuning the space, time, and host distribution of mycobacteria in wildlifeChristian Gortazar
IREC National Wildlife Research Institute CSIC UCLM JCCM, Ciudad Real, Spain
BMC Microbiol 11:27. 2011We describe the diversity of two kinds of mycobacteria isolates, environmental mycobacteria and Mycobacterium bovis collected from wild boar, fallow deer, red deer and cattle in Doñana National Park (DNP, Spain), analyzing their ..
- Susceptibility of raccoons (Procyon lotor) to infection with Mycobacterium bovisMitchell V Palmer
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Services, USDA, 2300 N Dayton Avenue, Ames, Iowa 50010, USA
J Wildl Dis 38:266-74. 2002Tuberculosis due to Mycobacterium bovis infection is endemic in white-tailed deer (Odocoileus virginianus) in the northeastern portion of the lower Michigan peninsula (USA)...
- European 1: a globally important clonal complex of Mycobacterium bovisNoel H Smith
Centre for Study of Evolution, University of Sussex, Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Surrey KT15 3NB, UK
Infect Genet Evol 11:1340-51. 2011We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M...
- Simultaneous measurement of antigen-stimulated interleukin-1 beta and gamma interferon production enhances test sensitivity for the detection of Mycobacterium bovis infection in cattleGareth J Jones
TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
Clin Vaccine Immunol 17:1946-51. 2010In order to identify cytokines that may be useful as candidates for inclusion in diagnostic tests for Mycobacterium bovis infection in cattle, we compared the levels of gamma interferon (IFN-γ), interleukin 1β (IL-1β), IL-4, IL-10, IL-..
- Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana)Scott D Fitzgerald
Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
J Wildl Dis 39:418-23. 2003..to evaluate the susceptibility of North American opossums (Didelphis virginiana) to aerosol inoculation of Mycobacterium bovis at two dose levels in order to gain information on disease pathogenesis, fecal shedding of the organism, ..
- Mycobacterium leprae actively modulates the cytokine response in naive human monocytesDaniel Sinsimer
Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Infect Immun 78:293-300. 2010..leprae compared with Mycobacterium bovis BCG stimulation. Interestingly, although in itself a weak stimulator of cytokines, M...
- Tuberculosis in badgers; a review of the disease and its significance for other animalsJ Gallagher
Central Veterinary Laboratory, Veterinary Laboratories Agency, Addlestone, Surrey, UK
Res Vet Sci 69:203-17. 2000..Trials of the effects of the removal of badgers on the occurrence of tuberculosis in cattle are summarised. It is concluded that badgers are well adapted as the primary host of bovine tuberculosis in parts of Britain and much of Ireland...
- Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosisNele Festjens
Unit for Medical Biotechnology, Department for Molecular Biomedical Research, Ghent, Belgium
EMBO Mol Med 3:222-34. 2011b>Mycobacterium bovis bacille Calmette-Guerin (BCG) provides only limited protection against pulmonary tuberculosis...
- Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-GuérinDilara Begum
Molecular Microbiology Group, COMB, Tropical Biosphere Research Center, Univeristy of the Ryukyus, Okinawa, Japan
Immunology 128:556-63. 2009..To evaluate the effect of vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) on the CD8(+) T-cell response to pulmonary M...
- Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004-2007E Rodriguez
National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Int J Tuberc Lung Dis 13:1536-41. 2009To identify the characteristics associated with human tuberculosis (TB) caused by Mycobacterium bovis and M. caprae in Spain.
- Mycobacterium caprae in cattle and humans in CroatiaZ Cvetnic
Croatian Veterinary Institute Zagreb, Zagreb, Croatia
Int J Tuberc Lung Dis 11:652-8. 2007..The children came from a family that ran a small-sized cattle dairy farm...
- Early response of bovine alveolar macrophages to infection with live and heat-killed Mycobacterium bovisStephanie Widdison
Livestock Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK
Dev Comp Immunol 35:580-91. 2011..role in the immune response to TB and recent studies provide insights into the interactions between Mϕ and Mycobacterium bovis. Here we reveal the early transcriptional response of bovine AlvMϕ to M. bovis infection...
- Estimating the true prevalence of Mycobacterium bovis in hunter-harvested white-tailed deer in MichiganDaniel J O'Brien
Rose Lake Wildlife Disease Laboratory, Michigan Department of Natural Resources, 8562 E Stoll Rd, East Lansing, Michigan 48823, USA
J Wildl Dis 40:42-52. 2004..In Michigan, the ability to estimate the true prevalence of bovine tuberculosis (TB; caused by Mycobacterium bovis) in free-ranging white-tailed deer (Odocoileus virginianus) will become increasingly important to ..
- Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam) assayE Gormley
Large Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Vet Microbiol 112:171-9. 2006..use of the gamma-interferon (IFN-gamma) assay (Bovigam) can provide a means for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal from an infected herd...
- Investigation of the transmission of Mycobacterium bovis from deer to cattle through indirect contactMitchell V Palmer
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, 2300 Dayton Ave, Ames, IA 50010, USA
Am J Vet Res 65:1483-9. 2004To investigate the infection of calves with Mycobacterium bovis through oral exposure and transmission of M. bovis from experimentally infected white-tailed deer to uninfected cattle through indirect contact.
- Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovisLeigh A L Corner
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
Tuberculosis (Edinb) 88:601-9. 2008b>Mycobacterium bovis is endemic in badger (Meles meles) populations of Ireland and the United Kingdom and infected badgers are a potential source of infection for cattle...
- The impact of transcriptomics on the fight against tuberculosis: focus on biomarkers, BCG vaccination, and immunotherapyCarlos Rodrigo Zarate-Blades
The Centre for Tuberculosis Research, Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
Clin Dev Immunol 2011:192630. 2011....
- Tuberculosis immunity: opportunities from studies with cattleW Ray Waters
National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
Clin Dev Immunol 2011:768542. 2011..Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals...
- Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattleClare Whelan
Enfer Scientific, Unit T, M7 Business Park, Newhall, Naas, County Kildare, Ireland
Clin Vaccine Immunol 15:1834-8. 2008..system and analyzed with a macro program that tracks each serum for its pattern of antibody activity for Mycobacterium bovis antigens...
- Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccinationDavid K Flaherty
Department of Internal Medicine, Division of Infectious Diseases, Center for Microbial Interface Biology, 420 West 12th Avenue, Columbus, OH 43210, USA
J Leukoc Biol 80:1262-71. 2006b>Mycobacterium bovis bacille Calmette Guerin (BCG), the current vaccine against infection with Mycobacterium tuberculosis, offers a variable, protective efficacy in man...
- Infection of Acanthamoeba castellanii with Mycobacterium bovis and M. bovis BCG and survival of M. bovis within the amoebaeStephanie J Taylor
Microbial Sciences Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
Appl Environ Microbiol 69:4316-9. 2003Survival of Mycobacterium bovis after ingestion by protozoa would provide an environmental reservoir for infection of cattle. We have shown that M. bovis survived ingestion by Acanthamoeba castellanii. In contrast, two strains of M...
- Molecular typing of Mycobacterium bovis strains isolated in Italy from 2000 to 2006 and evaluation of variable-number tandem repeats for geographically optimized genotypingM Beatrice Boniotti
Centro Nazionale di Referenza per la Tubercolosi Bovina, Istituto Zooprofilattico Sperimentale Lombardia e Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy
J Clin Microbiol 47:636-44. 2009Spoligotyping and exact tandem repeat (ETR) analysis of Mycobacterium bovis and M...
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisA Banerjee
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
Science 263:227-30. 1994..These results suggest that InhA is likely a primary target of action for INH and ETH...
- Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattleMartin Vordermeier
Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 151:8-13. 2011..progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test)...
- Identification of a Mycobacterium bovis BCG 45/47-kilodalton antigen complex, an immunodominant target for antibody response after immunization with living bacteriaF Romain
Unité de Physiopathologie de l Infection, Institut Pasteur, Paris, France
Infect Immun 61:742-50. 1993..tuberculosis is induced mainly by a previous immunization with living avirulent mycobacteria, usually Mycobacterium bovis BCG...
- Immunomagnetic recovery of Mycobacterium bovis from naturally infected environmental samplesF P Sweeney
Department of Biological Sciences, University of Warwick, Coventry, UK
Lett Appl Microbiol 43:364-9. 2006To adapt an immunomagnetic capture (IMC) technique to concentrate and cultivate Mycobacterium bovis from environmental samples including soil, faeces and urine.
- Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophagesJanice J Endsley
Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
J Leukoc Biol 79:71-9. 2006..of granulysin, interferon-gamma, and perforin and have cytotoxic activity against human tumor cells and Mycobacterium bovis bacillus Calmette-Guerin-infected alveolar and monocyte-derived macrophages...
- Mycobacterium bovis with different genotypes and from different hosts induce dissimilar immunopathological lesions in a mouse model of tuberculosisD Aguilar Leon
Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition, Salvador Zubiran, Mexico City, Mexico
Clin Exp Immunol 157:139-47. 2009With the hypothesis that genetic variability of Mycobacterium bovis could influence virulence and immunopathology, five M...
- Molecular detection of Mycobacterium bovis and Mycobacterium bovis BCG (Pasteur) in soilJamie S Young
Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom
Appl Environ Microbiol 71:1946-52. 2005PCR primers specific for the Mycobacterium tuberculosis complex were used to detect the presence of Mycobacterium bovis BCG (Pasteur) in soil microcosms and Mycobacterium bovis in environmental samples taken from a farm in Ireland with a ..
- Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7N R Chu
StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Exp Immunol 121:216-25. 2000..carcinoma, an immunotherapy based on the administration of an adjuvant-free fusion protein comprising Mycobacterium bovis BCG heat shock protein (hsp)65 linked to HPV16 E7 (hspE7) has been developed...
- Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activityJanice J Endsley
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, United States
Vaccine 25:8384-94. 2007..used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG)...
- Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosisSylvie Bertholet
Infectious Disease Research Institute, Seattle WA 98104, USA
J Immunol 181:7948-57. 2008..This study identified numerous novel human T cell Ags suitable to be included in subunit vaccines against tuberculosis...
- T Cell- Mediated Immunity to Mycobacterial InfectionMatthew Williams; Fiscal Year: 2005..In contrast, Mycobacterium bovis bacillus Calmette-Guerin (BCG) persists in the face of detectable CD4 and CD8 T cell responses, with much ..
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Expression signatures of TB-specific memory responses within the human lungRichard F Silver; Fiscal Year: 2013..lung, and to clarify the basis for the suboptimal efficacy of current TB vaccination with the attenuated Mycobacterium bovis strain the Bacillus of Calmette and Guerin (BCG)...
- Novel Bacillus subtilis based spore vaccine to tuberculosisSubramanian Dhandayuthapani; Fiscal Year: 2013..Attenuated Mycobacterium bovis BCG has long been used as a vaccine against TB, but its efficacy is variable for different populations...
- CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATIONStephen W Chensue; Fiscal Year: 2013..This hypothesis will be tested under conditions of Mycobacterium bovis and Schistosoma mansoni exposure by way of the following aims...
- The Role of CD1a in Protecting Against Human TuberculosisChetan Seshadri; Fiscal Year: 2013..b>Mycobacterium bovis Bacille Calmette-Guerin (BCG) is the only registered TB vaccine currently available and protects against ..
- A Novel Oral Combination Pediatric HIV and TB VaccineMichelle H Larsen; Fiscal Year: 2012..However, for obvious safety reasons, live attenuated HIV vaccination is not feasible. Mycobacterium bovis bacilli Calmette-Guerin (BCG) vaccination induces strong T helper 1 (Th1) responses in human infants...
- Role of WhiB3 in M. tuberculosis virulenceADRIE JC STEYN; Fiscal Year: 2013..2 domain of RpoV, the principal sigma factor in Mycobacterium bovis, is attenuating...
- MECHANISM OF MYCOBACTERIUM TUBERCULOSIS PERSISTENCEADRIE JC STEYN; Fiscal Year: 2012..2 domain of RpoV, the principal sigma factor in 515 Mycobacterium bovis, is attenuating...
- Systems Biology for Molecular Analysis of Tuberculosis in EthiopiaGobena Ameni; Fiscal Year: 2013..The Bacillus Calmette Guerin (BCG) vaccine consisting of attenuated Mycobacterium bovis preparations is the only approved vaccine against TB, but no longer provides protective immunity in some ..
- Role of WhiB3 in M. tuberculosis virulenceADRIE STEYN; Fiscal Year: 2009..2 domain of RpoV, the principal sigma factor in Mycobacterium bovis, is attenuating...
- BCG as an HIV vaccine vectorAnna Lise Williamson; Fiscal Year: 2011..The focus of this application is the use of Mycobacterium bovis bacille Calmette-Gu[unreadable]rin (BCG) as an HIV vaccine vector...
- Tuberculosis epidemiology and novel transmission routes in rural TanzaniaPhilip C Hopewell; Fiscal Year: 2013..of human TB (presumably due to Mycobacterium tuberculosis), human TB from animal origin (zoonotic TB due to Mycobacterium bovis) is an important and re-emerging public health concern in developing countries...
- The Role of Ras-Mediated Macropinocytosis in BCG Treatment of Bladder CancerRORY JOSEPH FLINN; Fiscal Year: 2013..The gold standard therapy for the majority of bladder cancers is instillation of an attenuated Mycobacterium Bovis, Bacillus Calmette-Gu[unreadable]rin (BCG), into the bladder, with 50% of patients positively responding to ..
- Modulation of Human Immunity by Mycobacterium lepraeCLAUDIA M A MANCA; Fiscal Year: 2013..Our studies comparing the immune responses in monocytes exposed to Mycobacterium bovis bacillus Calmette-Guerin (BCG) versus M...
- Bladder transcriptome in experimental inflammationRicardo Saban; Fiscal Year: 2009..b>Mycobacterium bovis bacillus Calmette-Gu[unreadable]rin (BCG) has long been demonstrated to be a potent stimulator of immune ..
- OPIATE MODULATION OF PULMONARY INFECTIONThomas Molitor; Fiscal Year: 2000..immunity, including HIV infection, foster the development of disseminated TB, whereas immunization with Mycobacterium bovis BCG vaccine confers protection against dissemination to the CNS...
- OXIDANT INDUCED BETA CHEMOKINES IN GRANULOMA FORMATIONJeffrey Warren; Fiscal Year: 2000..Likewise, in Mycobacterium bovis (BCG) - infected mice, there is an early, transient inflex of neutrophils into sites of subsequent ..
- HEAT SHOCK PROTEIN RECOGNITION/GAMMA-DELTA T CELL SUBSETREBECCA O BRIEN; Fiscal Year: 1993..4. To examine the immunological role of this subset of gammadelta cells. We will immunize mice with Mycobacterium bovis BCG to see if cells from this subset become amplified, and if so, will examine the kinetics of their ..
- The Role of SP-A in Pulmonary Host DefenseVIRGINIA SHEPHERD; Fiscal Year: 2004..We have shown in preliminary studies that Mycobacterium bovis BCG and Mycobacterium avium internalization by macrophages is enhanced by opsonization with SP-A...
- MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGENCarl Nathan; Fiscal Year: 2003..We will focus first on AhpC, recently shown to be a virulence factor for Mycobacterium bovis, and analyze the impact of mutations, its biochemical mechanism and its expression in Mtb...
- SP-A Receptor Modulation of Macrophage PhagocytosisZissis Chroneos; Fiscal Year: 2004..To facilitate these studies we will utilize immature alveolar macrophages that we have isolated, and Mycobacterium bovis BCG and Mycobacterium tuberculosis Ra reporter strains that express green fluorescent protein...
- IMPROVED VACCINIA RECOMBINANTS FOR TUBERCULOSIS VACCINEAnthony Coates; Fiscal Year: 1991A new vaccine for tuberculosis is required. Although the existing, live Mycobacterium bovis BCG vaccine protects children against tuberculosis in many countries, it causes side-effects, such as fatal disseminated disease in ..
- ANTITUMOR ACTIVE COMPONENTS OF BCG CELL WALLSGary Gray; Fiscal Year: 1993Preparations consisting of the cell walls of Mycobacterium bovis or M. smegmatis possess potent activity in experimental as well as human cancer immunotherapy...
- Mechanisms of Regulation of Autoimmune Th1 CD4 T cellsDYANA DALTON; Fiscal Year: 2007..IFN-y and nitric oxide play important roles in turning off the immune response during infection with Mycobacterium bovis (BCG) and during experimental autoimmune encephalomyelitis (EAE), a mouse model for the autoimmune disease ..
- H INFLUENZAE VACCINE BASED ON RECOMBINANT BCGMark Hanson; Fiscal Year: 1993BCG (Bacille Calmette-Guerin), and attenuated strain of Mycobacterium bovis that is used in viable form to vaccinate humans against tuberculosis, offers a number of unique advantages for development as a multivalent vaccine vehicle...
- An Efficient Bacterial Vector-Based Tuberculosis VaccineMARIA SZUMANSKI; Fiscal Year: 2001..Although Mycobacterium bovis strain BCG is widely used for TB prophylaxis, its protective effect has recently been shown to be far below ..
- Unraveling the Molecular Mechanisms of Phagocytosis(RMI)Fabienne Paumet; Fiscal Year: 2005..infectious disease is tuberculosis caused by mycobacterium tuberculosis (and to much lesser extent mycobacterium bovis). M...
- Nonpathogenic Mycobacteria:Anti-Bladder Tumor TherapyGlenn Fennelly; Fiscal Year: 2005..In particular, we will study the efficacy of wild type Mycobacterium smegmatis, and Mycobacterium bovis BCG, or alternative modified mycobacteria, for the delivery of genes that express functional cytokines or ..
- Traffic from chronic mycobacterium induced granulomasMatyas Sandor; Fiscal Year: 2009..We will induce granulomas in murine liver using a Mycobacterium bovis strain bacille Calmette Guirin (BCG) infection model...
- HYPEREXPRESSION SYSTEM FOR RECOMBINANT BCG VACCINESCharles Stover; Fiscal Year: 1992BCG, a live attenuated strain of Mycobacterium bovis, offers a number of distinct advantages as a live recombinant vaccine vehicle...
- Rapid Antibiotic Susceptibility TestingRonald Rieder; Fiscal Year: 2003..tool will be demonstrated with antimicrobial drug resistant strains of Mycobacterium smegmatis and Mycobacterium bovis BCG within a 12-month Phase I effort...
- EXPRESSION OF MTB ANTIGENS BY INFECTED MACROPHAGESTERRY POTTER; Fiscal Year: 1999..Although vaccination with the BCG strain of Mycobacterium bovis may be beneficial in lowering the incidence of tuberculosis in children, such vaccination provides little, ..
- MECHANISM OF TUMOR ABROGATION BY GLYCOLIPID A1ZULEMA REGGIARDO; Fiscal Year: 1980..mechanism(s) of the antitumor effect of glycolipid A1 which has been recently isolated and purified from Mycobacterium bovis BCG in these laboratories...
- Characterization of the Francisella tularensis phagosomeMARCUS HORWITZ; Fiscal Year: 2003..tularensis subverts the host cell membrane trafficking pathways and attains an intracellular compartment that is hospitable for its survival and growth will help guide new strategies for the prevention and treatment of tularemia. ..
- DEVELOPMENT AND TESTING OF NEW TUBERCULOSIS VACCINESMARCUS AARON HORWITZ; Fiscal Year: 2010..tuberculosis. Lay Summary: Tuberculosis is a major worldwide public health problem. This proposal seeks to develop a more potent vaccine with which to combat this disease. ..
- A TB Vaccine for AIDS PatientsMARCUS AARON HORWITZ; Fiscal Year: 2010..BCG, a live attenuated strain of Mycobacterium bovis, is the TB vaccine currently used throughout much of the world...
- Therapeutic Targeting Agents for Bladder CancerYi Luo; Fiscal Year: 2005..abstract_text> ..
- M TUBERCULOSIS GLUTAMINE SYNTHETASE EXPORT & INHIBITIONMARCUS HORWITZ; Fiscal Year: 2002..tuberculosis glutamine synthetase, they hope to develop more active entities than the parent compound and thereby to develop a new antibiotic against M. tuberculosis. ..
- Novel Antimicrobial Agents Against M. tuberculosisMARCUS HORWITZ; Fiscal Year: 2008..mammalian GS, and test the toxicity of the analogs in mice. 2) Test the novel MSO analogs for their capacity to inhibit M. tuberculosis growth in broth culture, in human macrophages, and in guinea pigs. ..
- Characterization of the M. tuberculosis phagosomeMARCUS HORWITZ; Fiscal Year: 2007..These experiments will advance our understanding of the cell biology and pathogenic mechanisms of M. tuberculosis and facilitate the development of new strategies to combat tuberculosis. [unreadable] [unreadable]..
- M TUBERCULOSIS PHAGOSOMEMARCUS HORWITZ; Fiscal Year: 2002..tuberculosis to survive and multiply within its host cells and should facilitate the development of new strategies for prevention and treatment of tuberculosis. ..
- BCG in Endogeneous and Exogenous Antigen-Induced T CellYi Luo; Fiscal Year: 2005..abstract_text> ..
- Vaccine Induced Mucosal Protection Against TB InfectionDANIEL HOFT; Fiscal Year: 2005..Prime/boosting strategies found to prevent BCG infection after aerosol challenges will be studied for the ability to prevent infection with virulent M. tuberculosis by aerosol challenge. ..
- FLAGELLAR POCKET OF LEISHMANIADavid Russell; Fiscal Year: 2001..abstract_text> ..
- Th1-to Th2 shift of HSP65 responses and atherogenesisYoshimi Shibata; Fiscal Year: 2005..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
- GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPPDavid Russell; Fiscal Year: 2004..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
- LATENCY AND REACTIVATION TUBERCULOSISYUKARI MANABE; Fiscal Year: 2006..Appropriate animal models are critical to the successful development of tuberculosis vaccines, new drugs and better diagnostic tests for tuberculosis. ..
- Metabolism of M. tuberculosis: New Targets for MDR TBDavid Russell; Fiscal Year: 2004..abstract_text> ..
- Zeiss LSM510 Meta Confocal MicroscopeDavid Russell; Fiscal Year: 2007..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. [unreadable] [unreadable] [unreadable]..
- IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSISYUKARI MANABE; Fiscal Year: 2003..Elucidation of this iron-dependent IdeR regulon may lead to the identification of virulence determinants, and novel antigens for vaccines and therapeutics. ..
- TRYPANOSOMA CRUZI MUCOSAL & SYSTEMIC PROTECTIVE IMMUNITYDANIEL HOFT; Fiscal Year: 2008..Chemokine and/or integrin receptor expression will be studied by flow cytometry and RT-Real-Time PCR, and the in vivo effects of defective chemokine and integrin binding and/or signaling will be evaluated. [unreadable] [unreadable]..
- Cell Biology of Mycobacterium tuberculosis InfectionDavid G Russell; Fiscal Year: 2010..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2009..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Chronic Tuberculosis: Latent or DynamicIan Orme; Fiscal Year: 2008..unreadable] [unreadable]..
- C. Neoformans Infection in Organ Transplant RecipientsNina Singh; Fiscal Year: 2005..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
- Development and cGMP Manufacture of a Vitrified Typhoid VaccineSIMS KOCHI; Fiscal Year: 2006..Meeting these goals will facilitate the advance of Ty800 as an oral, single-dose vaccine that can be delivered outside of the storage cold chain. [unreadable] [unreadable]..
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
- Neurodevelopment and HIV/AIDSAnnelies Van Rie; Fiscal Year: 2005....
- Non-replicative Vaccine for Human BrucellosisRamesh Vemulapalli; Fiscal Year: 2011..At present there is no vaccine available for prevention of brucellosis in humans. Research proposed in this application focuses on developing a highly effective and safe Brucella vaccine for human use. ..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
- Duke University Center for Translational ResearchRichard Frothingham; Fiscal Year: 2006....