mycobacterium avium

Summary

Summary: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.

Top Publications

  1. pmc Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection
    Jutta Sharbati
    Institute of Veterinary Biochemistry, Freie Universitaet Berlin, Berlin, Germany
    PLoS ONE 6:e20258. 2011
  2. pmc Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 282:25779-89. 2007
  3. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011
  4. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
  5. ncbi Molecular evidence to support a proposal to reserve the designation Mycobacterium avium subsp. avium for bird-type isolates and 'M. avium subsp. hominissuis' for the human/porcine type of M. avium
    Wouter Mijs
    Innogenetics N V, Ghent, Belgium
    Int J Syst Evol Microbiol 52:1505-18. 2002
  6. ncbi Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni
    Randy Sacco
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Immunol 104:274-81. 2002
  7. ncbi A comparison of ovine monocyte-derived macrophage function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
    Sven T Berger
    Disease Research Laboratory, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 84:349-56. 2006
  8. ncbi The distribution of Mycobacterium avium ssp. paratuberculosis in the environment surrounding Minnesota dairy farms
    E A Raizman
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, MN 55455, USA
    J Dairy Sci 87:2959-66. 2004
  9. ncbi Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues
    M Moravkova
    Veterinary Research Institute Brno, Department of Food and Feed Safety, Hudcova 70, 621 32 Brno, Czech Republic
    Res Vet Sci 85:257-64. 2008
  10. ncbi Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis
    Judith T Murphy
    Center for Animal Functional Genomics and Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
    Physiol Genomics 28:67-75. 2006

Detail Information

Publications312 found, 100 shown here

  1. pmc Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection
    Jutta Sharbati
    Institute of Veterinary Biochemistry, Freie Universitaet Berlin, Berlin, Germany
    PLoS ONE 6:e20258. 2011
    ..Therefore, we present a comprehensive study for identification of these key regulators and their targets in the context of host macrophage response to mycobacterial infections...
  2. pmc Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 282:25779-89. 2007
    b>Mycobacterium avium is a major opportunistic pathogen in HIV-positive individuals and is responsible for increased morbidity and mortality in AIDS patients. M...
  3. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011
    To investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium, TLR9, TLR2, and MyD88 knockout (KO) mice were infected with this bacterium...
  4. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
    b>Mycobacterium avium subsp hominissuis (previously Mycobacterium avium subsp avium) is an environmental organism associated with opportunistic infections in humans...
  5. ncbi Molecular evidence to support a proposal to reserve the designation Mycobacterium avium subsp. avium for bird-type isolates and 'M. avium subsp. hominissuis' for the human/porcine type of M. avium
    Wouter Mijs
    Innogenetics N V, Ghent, Belgium
    Int J Syst Evol Microbiol 52:1505-18. 2002
    In an attempt to clarify the taxonomy of the Mycobacterium avium complex, the relationship between IS1245 RFLP, growth temperature, 16S rDNA signature sequences and the 16S-23S rDNA internally transcribed spacer (ITS) of 160 M...
  6. ncbi Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni
    Randy Sacco
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Immunol 104:274-81. 2002
    b>Mycobacterium avium established a systemic infection with granulomatous inflammation in mice. Mice chronically infected with M...
  7. ncbi A comparison of ovine monocyte-derived macrophage function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
    Sven T Berger
    Disease Research Laboratory, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 84:349-56. 2006
    b>Mycobacterium avium ssp. paratuberculosis causes Johne's disease in ruminants, whereas the antigenically and genetically similar subspecies Mycobacterium avium ssp. avium is less virulent...
  8. ncbi The distribution of Mycobacterium avium ssp. paratuberculosis in the environment surrounding Minnesota dairy farms
    E A Raizman
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, MN 55455, USA
    J Dairy Sci 87:2959-66. 2004
    ..The study results indicate that targeted sampling of cow alleyways and manure storage areas appears to be an alternative strategy for herd screening and Johne's infection status assessment and for estimating herd fecal prevalence...
  9. ncbi Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues
    M Moravkova
    Veterinary Research Institute Brno, Department of Food and Feed Safety, Hudcova 70, 621 32 Brno, Czech Republic
    Res Vet Sci 85:257-64. 2008
    The members of Mycobacterium avium species, comprising M. avium subsp. paratuberculosis, M. a. hominissuis, M. a. avium, M. a...
  10. ncbi Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis
    Judith T Murphy
    Center for Animal Functional Genomics and Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
    Physiol Genomics 28:67-75. 2006
    b>Mycobacterium avium subspecies paratuberculosis (MAP) and Mycobacterium avium subspecies avium (MAA) represent two closely related intracellular bacteria with vastly different associated pathologies...
  11. pmc Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 116:3485-93. 2010
    ..Here, we show that Mycobacterium avium-infected T cell-deficient mice injected with CD4 T cells also develop an immune reconstitution disease (IRD)..
  12. pmc Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Center for Medicine and Biosciences, D 23845 Borstel, Germany
    J Exp Med 194:1847-59. 2001
    ..Aerosol infection in mice with the highly virulent Mycobacterium avium strain TMC724 causes progressive pulmonary pathology strongly resembling caseating necrosis in human ..
  13. ncbi Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis
    S Aly
    Division of Molecular Infection Biology, Research Centre Borstel, D 23845 Borstel, Germany
    J Pathol 212:295-305. 2007
    ..Lung histopathology of C57BL/6 (WT) mice 16 weeks after aerosol infection with Mycobacterium avium strain TMC724 is uniquely characterized by centrally necrotizing granulomas, strongly resembling human TB ..
  14. pmc IS1245 restriction fragment length polymorphism typing of Mycobacterium avium isolates: proposal for standardization
    D van Soolingen
    Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 36:3051-4. 1998
    b>Mycobacterium avium has become a major human pathogen, primarily due to the emergence of the AIDS epidemic...
  15. ncbi Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104
    J B Torrelles
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 82:293-300. 2002
    Members of the Mycobacterium avium complex (MAC) are responsible for mycobacterial disease in children, the aged and in immunocompromised individuals...
  16. pmc Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms
    Yong Jun Li
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Med Microbiol 59:8-16. 2010
    b>Mycobacterium avium is an opportunistic pathogen associated with pulmonary disease in non-AIDS patients and disseminated infection in patients with AIDS...
  17. ncbi Real-time quantitative PCR detection of Mycobacterium avium subspecies in meat products
    B Klanicova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    J Food Prot 74:636-40. 2011
    The aim of this work was to examine various purchased meat products and to find out if any traces of Mycobacterium avium subsp. avium, M. avium subsp. hominissuis, and M. avium subsp. paratuberculosis could be detected in these samples...
  18. ncbi Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. avium
    Franck Biet
    UR1282, Infectiologie Animale, Santé Publique, INRA Centre de Tours, F 37380 Nouzilly, France
    Vaccine 26:257-68. 2008
    ..These surface-located GPLs are involved in pathogenicity by interfering with the host immune system. In Mycobacterium avium subsp...
  19. ncbi Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily
    Jeng Yeong Chow
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore
    Biochemistry 48:4344-53. 2009
    ..Using a quorum-quenching lactonase from Mycobacterium avium subsp...
  20. ncbi Comparison of three DNA extraction methods for Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium subsp. avium
    A Amaro
    Laboratório Nacional de Investigação Veterinária, Lisboa, Portugal
    Lett Appl Microbiol 47:8-11. 2008
    To compare three methods for DNA extraction from Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium subsp. avium.
  21. ncbi Optimization of electroporation conditions for Mycobacterium avium
    S H Lee
    Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
    Tuberculosis (Edinb) 82:167-74. 2002
    Successful transformation and subsequent genetic manipulation of Mycobacterium avium requires suitable vectors, efficient transformation systems, and reliable selectable markers...
  22. ncbi A major cell wall lipopeptide of Mycobacterium avium subspecies paratuberculosis
    Torsten M Eckstein
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 281:5209-15. 2006
    b>Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne disease in cattle and other ruminants, is proposed to be at least one of the causes of Crohn disease in humans...
  23. ncbi Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium
    Cleverson D Souza
    Department of Veterinary Science, University of Minnesota, St Paul, MN 55108, USA
    Microbes Infect 9:1545-52. 2007
    ..of activation and antimicrobial activities of MAPK-p38 and MAPK-ERK in bovine monocytes infected with Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium avium subsp. avium (Maa)...
  24. pmc Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium
    Dharshini Jeevarajah
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Bacteriol 186:6792-9. 2004
    ..Four methyltransferases have been implicated in the synthesis of the GPLs of Mycobacterium smegmatis and Mycobacterium avium. A rhamnosyl 3-O-methytransferase and a fatty acid methyltransferase of M...
  25. ncbi Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subsp. avium infections in a tule elk (Cervus elaphus nannodes) herd
    Graham C Crawford
    Wildlife Health Center, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, California 95616, USA
    J Wildl Dis 42:715-23. 2006
    ..were identified by a multiplex polymerase chain reaction (PCR) that discriminates among members of the Mycobacterium avium complex (MAC)...
  26. pmc Investigation of an outbreak of mycobacteriosis in pigs
    Angelika Agdestein
    Norwegian Veterinary Institute, N 0106 Oslo, Norway
    BMC Vet Res 7:63. 2011
    ..An investigation of potential mycobacteriosis in the pigs imported to Serbia and the possible source of infection in the Lithuanian herd were therefore initialised...
  27. ncbi Multiple strains of Mycobacterium avium subspecies hominissuis infections associated with aborted fetuses and wasting in pigs
    G J Wellenberg
    Animal Health Service GD Deventer, 7400 AA, Deventer, The Netherlands
    Vet Rec 167:451-4. 2010
    ..The specimen cultures were identified as Mycobacterium avium subspecies hominissuis using IS1245-specific PCR and IS1245 restriction fragment length polymorphism (RFLP)...
  28. pmc Natural occurrence of horizontal transfer of Mycobacterium avium- specific insertion sequence IS1245 to Mycobacterium kansasii
    Michelle Christiane da Silva Rabello
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu, 862 3 degrees andar, 04023 062 Sao Paulo, SP, Brazil
    J Clin Microbiol 48:2257-9. 2010
    Mycobacterium kansasii carrying IS1245, a highly prevalent insertion sequence among Mycobacterium avium isolates, was detected in a mixed culture of M. avium and M. kansasii...
  29. pmc Prevalence of Mycobacterium avium in slaughter pigs in The Netherlands and comparison of IS1245 restriction fragment length polymorphism patterns of porcine and human isolates
    R E Komijn
    National Inspection Service for Livestock and Meat, 2270 JA Voorburg, The Netherlands
    J Clin Microbiol 37:1254-9. 1999
    ..In a follow-up study, Mycobacterium avium complex (MAC) bacteria were isolated from 219 of 402 affected lymph nodes (54.2%)...
  30. pmc Mutational analysis of cell wall biosynthesis in Mycobacterium avium
    Jean Pierre Laurent
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Bacteriol 185:5003-6. 2003
    The cell wall of the environmental pathogen Mycobacterium avium is important to its virulence and intrinsic antimicrobial resistance...
  31. ncbi Apoptosis of CD4+ and CD8+ T cells during experimental infection with Mycobacterium avium is controlled by Fas/FasL and Bcl-2-sensitive pathways, respectively
    Jie Zhong
    Department of Microbiology and Immunology, University of Melbourne, Australia
    Immunol Cell Biol 81:480-6. 2003
    Both CD4+ and CD8+ T cells from mice infected with Mycobacterium avium suffered a high rate of apoptosis, beginning with the onset of the immune response and culminating in the loss of T cells from the tissues and loss of IFN-gamma ..
  32. pmc Molecular characterization of pigmented and nonpigmented isolates of Mycobacterium avium subsp. paratuberculosis
    Karen Stevenson
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, United Kingdom
    J Clin Microbiol 40:1798-804. 2002
    Five pigmented isolates of Mycobacterium avium subsp. paratuberculosis were examined by pulsed-field gel electrophoresis (PFGE), IS900 restriction fragment length polymorphism (IS900-RFLP), and IS1311 polymorphism analysis using PCR...
  33. ncbi Optimization of methods for detecting Mycobacterium avium subsp. paratuberculosis in environmental samples using quantitative, real-time PCR
    Kimberly L Cook
    AWMRU, USDA ARS, 230 Bennett Lane, Bowling Green, KY 42104, USA
    J Microbiol Methods 69:154-60. 2007
    Detection of Johne's disease, an enteric infection of cattle caused by Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis), has been impeded by the lack of rapid, reliable detection methods...
  34. pmc Short-sequence-repeat analysis of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium isolates collected from animals throughout the United States reveals both stability of loci and extensive diversity
    N Beth Harris
    National Veterinary Services Laboratories, Ames, IA 50010, USA
    J Clin Microbiol 44:2970-3. 2006
    We analyzed the multilocus short sequence repeats (SSRs) of 211 and 56 isolates of Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium, respectively. The M. avium subsp...
  35. ncbi Mycobacterial interspersed repetitive units (MIRU) differentiate Mycobacterium avium subspecies paratuberculosis from other species of the Mycobacterium avium complex
    T J Bull
    Department of Surgery, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Mol Cell Probes 17:157-64. 2003
    ..We have identified MIRU at 18 conserved loci throughout the common portions of the Mycobacterium avium subspecies paratuberculosis (MAP) and M. avium subspecies avium (MAA) genomes...
  36. pmc A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen
    Marcela Parra
    Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 74:786-9. 2006
    Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited...
  37. pmc New variable-number tandem-repeat markers for typing Mycobacterium avium subsp. paratuberculosis and M. avium strains: comparison with IS900 and IS1245 restriction fragment length polymorphism typing
    Virginie C Thibault
    UR1282, Infectiologie Animale, Santé Publique IASP 311, INRA Centre de Tours, F 37380 Nouzilly, France
    J Clin Microbiol 45:2404-10. 2007
    b>Mycobacterium avium subsp. paratuberculosis, the etiological agent of paratuberculosis, affects a wide range of domestic ruminants and has been suggested to be involved in Crohn's disease in humans...
  38. ncbi Recombinant interleukin-4-treated macrophages, epithelioid cell surrogates, harbor and arrest Mycobacterium avium multiplication in vitro
    Ludmilla T D Chinen
    Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Rua Botucatu 862, 4th andar, Vila Clementino, 04023 900 São Paulo, Brazil
    Microbes Infect 8:965-73. 2006
    ..T-cell lymphoproliferation assays using ovalbumin (OVA) and Mycobacterium avium as antigens showed that both cultured macrophages were equally efficient as antigen presenting cells (APCs)...
  39. ncbi IS1245 RFLP-based genotyping study of Mycobacterium avium subsp. hominissuis isolates from pigs and humans
    Mateja Pate
    University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbiceva 60, 1115 Ljubljana, Slovenia
    Comp Immunol Microbiol Infect Dis 31:537-50. 2008
    b>Mycobacterium avium subsp. hominissuis, ubiquitous environmental mycobacterium, is an opportunistic pathogen that is regularly isolated from pigs and humans in Slovenia...
  40. ncbi Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages
    Sushil Kumar Pathak
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Calcutta 700009, India
    J Biol Chem 279:55127-36. 2004
    ..Our studies demonstrate that the NF-kappaB and CRE elements of the COX-2 promoter are critical to Mycobacterium avium-induced COX-2 gene expression. M. avium-triggered signaling originates at the Toll-like receptor 2 (TLR2)...
  41. pmc Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase
    T Hayashi
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 69:6156-64. 2001
    ..Based on these activities, we investigated whether ISS-ODN could modify the course of Mycobacterium avium infection. M...
  42. ncbi Lateral gene transfer in Mycobacterium avium subspecies paratuberculosis
    Pradeep Reddy Marri
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Can J Microbiol 52:560-9. 2006
    ..Here, we report instances of lateral gene transfer in Mycobacterium avium subsp. paratuberculosis, a pathogenic bacteria that causes Johne's disease in cattle...
  43. pmc Regulation of expression of major histocompatibility antigens by bovine macrophages infected with Mycobacterium avium subsp. paratuberculosis or Mycobacterium avium subsp. avium
    D J Weiss
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    Infect Immun 69:1002-8. 2001
    b>Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium are antigenically and genetically very similar organisms; however, they differ markedly in their virulence for cattle...
  44. pmc Whole-genome plasticity among Mycobacterium avium subspecies: insights from comparative genomic hybridizations
    Chia Wei Wu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706 1581
    J Bacteriol 188:711-23. 2006
    Infection with Mycobacterium avium subsp. paratuberculosis causes Johne's disease in cattle and is also implicated in cases of Crohn's disease in humans. Another closely related strain, M. avium subsp...
  45. pmc The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria
    Stephan Schmitz-Esser
    Department of Microbial Ecology, University of Vienna, Vienna, Austria
    J Bacteriol 192:1045-57. 2010
    ..bacteria (including chlamydiae, Legionella pneumophila, Rickettsia bellii, Francisella tularensis, and Mycobacterium avium)...
  46. pmc Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts
    Monica Hagedorn
    Departement de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Science 323:1729-33. 2009
    ..This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells...
  47. pmc Susceptibility of beige mice to Mycobacterium avium: role of neutrophils
    R Appelberg
    Centro de Citologia Experimental, University of Porto, Portugal
    Infect Immun 63:3381-7. 1995
    The beige mutation in C57BL/6 mice has been shown to increase the susceptibility to infection by Mycobacterium avium. In this study, we confirmed those results and showed that the effect of the beige mutation was most obvious after ..
  48. ncbi Causation of Crohn's disease by Mycobacterium avium subspecies paratuberculosis
    J Hermon-Taylor
    St George s Hospital Medical School, London, United Kingdom
    Can J Gastroenterol 14:521-39. 2000
    b>Mycobacterium avium subspecies paratuberculosis (MAP) is a member of the M avium complex (MAC)...
  49. ncbi Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner
    Lindsay Sweet
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    J Leukoc Biol 80:415-23. 2006
    ..susceptible to infection by Mycobacterium tuberculosis, Mycobacterium bovis bacillus Calmette-Guerin, and Mycobacterium avium. Therefore, it is important to define the molecules expressed by pathogenic mycobacteria, which bind the ..
  50. ncbi Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis
    Liliana Rodrigues
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    J Antimicrob Chemother 61:1076-82. 2008
    Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M...
  51. pmc Comparative genomic analysis of Mycobacterium avium subspecies obtained from multiple host species
    Michael L Paustian
    National Animal Disease Center, USDA ARS, Ames, USA
    BMC Genomics 9:135. 2008
    b>Mycobacterium avium (M. avium) subspecies vary widely in both pathogenicity and host specificity, but the genetic features contributing to this diversity remain unclear.
  52. ncbi Modulation of eukaryotic cell apoptosis by members of the bacterial order Actinomycetales
    Daniel P Barry
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
    Apoptosis 11:1695-707. 2006
    ..Rather than covering the entire field, this review focuses on the dysregulation of host cell apoptosis by members of the order Actinomycetales, containing the genera Corynebacterium, Mycobacterium, Rhodococcus, and Nocardia...
  53. pmc A novel enzyme-linked immunosorbent assay for diagnosis of Mycobacterium avium subsp. paratuberculosis infections (Johne's Disease) in cattle
    C A Speer
    Center for Wildlife Health, Department of Forestry, Wildlife and Fisheries, The University of Tennessee, P O Box 1071, Knoxville, TN 37901 1071, USA
    Clin Vaccine Immunol 13:535-40. 2006
    Enzyme-linked immunosorbent assays (ELISAs) for the diagnosis of Johne's disease (JD), caused by Mycobacterium avium subsp...
  54. ncbi Survival of Mycobacterium avium in a model distribution system
    Cheryl D Norton
    American Water, Quality Control and Research Laboratory, 1115 South Illinois Street, Belleville, IL 62220, USA
    Water Res 38:1457-66. 2004
    ..avium complex in drinking water biofilms...
  55. pmc Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium
    M S Gomes
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Portugal
    Immunology 95:165-8. 1998
    In the mouse, the progression of the Mycobacterium avium infection is highly dependent on the Nramp1 gene. Strains of mice that express the Nramp1D169 allele are highly susceptible to M...
  56. ncbi Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium
    J M Garrido
    NEIKER Tecnalia, Animal Health Department, 48160 Derio, Bizkaia, Spain
    Vet Microbiol 144:240-5. 2010
    ..We aimed to characterize the first experimental Mycobacterium avium subsp...
  57. ncbi Isolation of mycobacteria other than Mycobacterium avium from porcine lymph nodes
    Jakko van Ingen
    National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vet Microbiol 144:250-3. 2010
    b>Mycobacterium avium causes lymphadenitis in pigs. This presents an economical burden, as these pigs meat is considered inappropriate for consumption...
  58. ncbi Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination
    David K Flaherty
    Department of Internal Medicine, Division of Infectious Diseases, Center for Microbial Interface Biology, 420 West 12th Avenue, Columbus, OH 43210, USA
    J Leukoc Biol 80:1262-71. 2006
    ..Mice were vaccinated with BCG and subsequently given repeated oral doses of live Mycobacterium avium to model exposure to environmental mycobacteria...
  59. ncbi Mycobacterium avium in a shower linked to pulmonary disease
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    J Water Health 6:209-13. 2008
    b>Mycobacterium avium was isolated from hot and cold water samples and from sediment (biofilm) collected from the showerhead in the home of a woman with M. avium pulmonary disease lacking known M. avium risk factors...
  60. ncbi Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor
    S Hussain
    Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210, USA
    J Immunol 163:2041-8. 1999
    ..the expression of a panel of IFN-gamma-inducible genes and activation of Janus Kinase (JAK)-STAT pathway in Mycobacterium avium-infected macrophages...
  61. ncbi The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis
    A J Cobb
    Veterans Affairs Medical Center, Durham, NC 27705, USA
    Vet Microbiol 67:31-5. 1999
    ..We cloned and sequenced the Mycobacterium avium and Mycobacterium paratuberculosis GroES genes. M. avium and M...
  62. ncbi Amplified fragment length polymorphism analysis of Mycobacterium avium complex isolates recovered from southern California
    Stacy L Pfaller
    National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, OH, USA
    J Med Microbiol 56:1152-60. 2007
    ..in order to identify possible sources of human exposure to opportunistic pathogens belonging to the Mycobacterium avium complex (MAC)...
  63. pmc Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction
    Joel Otero
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Appl Environ Microbiol 69:5039-44. 2003
    Mycobacterium tuberculosis and Mycobacterium avium are pathogenic slow-growing mycobacteria that cause distinct human diseases. In contrast to recent advances in M. tuberculosis genetics and pathogenesis investigation, M...
  64. pmc Identification of Mycobacterium avium genotypes with distinctive traits by combination of IS1245-based restriction fragment length polymorphism and restriction analysis of hsp65
    R S Oliveira
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, UNIFESP EPM, Sao Paulo, Brazil
    J Clin Microbiol 41:44-9. 2003
    One-hundred eight Mycobacterium avium isolates from pigs, humans, birds, and bovines were typed by the IS1245-based restriction fragment length polymorphism (RFLP) method and PCR-restriction enzyme analysis (PRA) of hsp65...
  65. pmc The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
    Kyung Tae Noh
    Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan 626 870, Korea Research Institute of Convergence of Biomedical Science and Technology, Pusan National University, Yangsan 626 770, Korea
    Exp Mol Med 44:340-9. 2012
    In this study, we showed the direct interaction between Mycobacterium avium subsp...
  66. pmc Genetic analysis of Mycobacterium avium complex strains used for producing purified protein derivatives
    Makeda Semret
    McGill University Health Centre, Montreal, Quebec, Canada
    Clin Vaccine Immunol 13:991-6. 2006
    ..Among these, reagents to detect infections by Mycobacterium avium complex organisms have been produced, but the utility of these reagents has not been clearly established ..
  67. ncbi Unique genotypes of Mycobacterium avium subsp. paratuberculosis strains of Type III
    Petra Möbius
    Institute of Molecular Pathogenesis, Friedrich Loeffler Institut Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany
    Vet Microbiol 139:398-404. 2009
    b>Mycobacterium avium subsp...
  68. ncbi Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase
    Andre Rosowsky
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Med Chem 47:2475-85. 2004
    ..as inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii (Pc), Toxoplasma gondii (Tg), and Mycobacterium avium (Ma), three of the opportunistic organisms known to cause significant morbidity and mortality in patients ..
  69. ncbi Role of iron in experimental Mycobacterium avium infection
    M S Gomes
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal
    J Clin Virol 20:117-22. 2001
    ..may underlie an increased susceptibility of AIDS patients to mycobacterial infections, namely by Mycobacterium avium. OBJECTIVES: The understanding of the role of iron metabolism during M...
  70. pmc Temporal effect of tumor necrosis factor alpha on murine macrophages infected with Mycobacterium avium
    I S Eriks
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164 7040, USA
    Infect Immun 65:2100-6. 1997
    Members of the Mycobacterium avium complex are a family of bacteria that persist within macrophages in the face of an immune response. Elimination of these organisms is likely due to cytokine-induced macrophage activation...
  71. pmc Expression of IL-18 by Mycobacterium avium-infected human monocytes; association with M. avium virulence
    H Shiratsuchi
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4984, USA
    Clin Exp Immunol 123:203-9. 2001
    Disseminated Mycobacterium avium infection is the most frequent bacterial infection in patients with advanced AIDS and also associated with interferon-gamma (IFN-gamma) or IL-12 receptor deficiency...
  72. ncbi Serotype-specific modulation of human monocyte functions by glycopeptidolipid (GPL) isolated from Mycobacterium avium complex
    Hideyuki Kano
    Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara 228 8555, Japan
    Biol Pharm Bull 28:335-9. 2005
    Immunomodulating activity of glycopeptidolipids (GPL), separated from different serovars of Mycobacterium avium complex (MAC), on macrophage functions was compared...
  73. ncbi Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis
    Martin Feller
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Lancet Infect Dis 7:607-13. 2007
    This systematic review assesses the evidence for an association between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease...
  74. ncbi Isolation and characterisation of Mycobacterium avium and Rhodococcus equi from granulomatous lesions of swine lymph nodes in Slovenia
    Mateja Pate
    Institute of Microbiology and Parasitology, Veterinary Faculty Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia
    Acta Vet Hung 52:143-50. 2004
    ..b>Mycobacterium avium alone was isolated in 47.3% of pigs and in mixed infection with Rhodococcus equi in 3.9% of pigs. R...
  75. ncbi Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens
    Lawrence Broxmeyer
    Med America Research, Whitestone, New York, USA
    J Infect Dis 186:1155-60. 2002
    b>Mycobacterium avium causes disseminated infection in patients with acquired immune deficiency syndrome. Mycobacterium tuberculosis is a pathogen associated with the deaths of millions of people worldwide annually...
  76. pmc Mycobacterium avium in the postgenomic era
    Christine Y Turenne
    McGill University Health Centre, A5 156, 1650 Cedar Avenue, Montreal H3G 1A4, Canada
    Clin Microbiol Rev 20:205-29. 2007
    The past several years have witnessed an upsurge of genomic data pertaining to the Mycobacterium avium complex (MAC)...
  77. pmc Impaired host defence against Mycobacterium avium in mice with chronic granulomatous disease
    M Fujita
    Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 160:457-60. 2010
    ..To determine whether or not NADPH oxidase is crucial to the host defence against Mycobacterium avium, we investigated the response against M. avium using CGD model mice (gp91-phox(-)) of C57BL/6 strain...
  78. pmc Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids
    Lindsay Sweet
    Department of Biological Sciences, Eck Institute for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Infect Immun 78:518-26. 2010
    ..that phagosomes containing silica beads coated with glycopeptidolipids (GPLs), a major surface component of Mycobacterium avium, showed limited acidification and delayed recruitment of late endosomal/lysosomal markers compared to those ..
  79. ncbi Different immune response of pigs to Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis infection
    Hana Stepanova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Vet Microbiol 159:343-50. 2012
    b>Mycobacterium avium subsp. avium (MAA) and Mycobacterium avium subsp. hominissuis (MAH) are the most common mycobacterial species isolated from granulomatous lesions in swine in countries with controlled bovine tuberculosis...
  80. ncbi PCR analysis of the presence and location of Mycobacterium avium in a constructed reed bed, with implications for avian tuberculosis control
    Julian A Drewe
    Institute of Zoology, Zoological Society of London, London, UK
    FEMS Microbiol Ecol 67:320-8. 2009
    ..Particular emphasis was placed on the presence and location of Mycobacterium avium--the causal agent of avian tuberculosis (ATB)--in an effort to clarify the potential role of reed beds in ..
  81. ncbi Elevated mitogen-activated protein kinase signalling and increased macrophage activation in cells infected with a glycopeptidolipid-deficient Mycobacterium avium
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    Cell Microbiol 8:85-96. 2006
    b>Mycobacterium avium is a significant cause of morbidity and mortality in AIDS patients. M. avium can be isolated as three major morphotypes: smooth-transparent (SmT ), smooth-opaque (SmO) and rough (Rg)...
  82. pmc Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
    Oyvind Halaas
    Department of Cancer Research and Molecular Medicine, Norges Teknisk Naturvitenskapelige Universitet, and St Olavs Hospital, Trondheim, Norway
    J Infect Dis 201:783-92. 2010
    ..Here we show that Lcn2 suppressed growth of Mycobacterium avium in culture, and M. avium induced Lcn2 production from mouse macrophages...
  83. ncbi Selective killing of Mycobacterium avium-infected macrophages by inhibition of phosphorylated signal transducer and activator of transcription type 1
    Sabrina Dominici
    Institutes of Biochemistry G Fornaini, University of Urbino Carlo Bo, Urbino, Italy
    J Infect Dis 198:95-100. 2008
    b>Mycobacterium avium infects mononuclear phagocytes, which thereby become reservoirs for this pathogen. Currently recommended therapy does not ensure the eradication of intracellular bacteria. Here, we report that M...
  84. ncbi Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity
    M Salomé Gomes
    Laboratory of Microbiology and Immunology of Infection, IBMC Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
    Eur J Immunol 38:2180-9. 2008
    ..immune response to mycobacterial infections, being required for optimal immunity against certain virulent Mycobacterium avium strains. Here we analyzed the role of TLR2 in the intra-macrophagic growth of M...
  85. pmc Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways
    Melanie J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    J Bacteriol 191:1132-42. 2009
    The Mycobacterium avium complex (MAC) is an important group of opportunistic pathogens for birds, cattle, swine, and immunosuppressed humans...
  86. ncbi Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages
    G F Schiavano
    Institute of Hygiene, University of Urbino, 61029, Urbino, Italy
    Int J Antimicrob Agents 18:525-30. 2001
    ..with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of Mycobacterium avium. Overall, clarithromycin-ethambutol-rifampicin was the most active combination tested...
  87. ncbi The cytolytic activity of natural killer cells is not involved in the restriction of Mycobacterium avium growth
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Int Immunol 15:895-901. 2003
    Severe combined immunodeficiency (SCID) mice were used to analyze the role of NK cells in resistance to Mycobacterium avium. The neutralization of IFN-gamma in these animals led to an exacerbation of the infection associated with a ..
  88. pmc Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection
    Horacio Bach
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St, Vancouver, V5Z 3J5 British Columbia, Canada
    Infect Immun 74:6540-6. 2006
    ..The genome sequence of Mycobacterium avium subsp. paratuberculosis, the causative agent of Johne's disease, does not possess a defined tyrosine kinase...
  89. ncbi Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
    Shigeru Ariki
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Immunol 187:2586-94. 2011
    ..b>Mycobacterium avium is one of the well-known opportunistic pathogens that can replicate within macrophages...
  90. ncbi Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Portugal
    J Leukoc Biol 76:1039-46. 2004
    ..ligand (OX40L), and CD137 ligand (4-1BBL) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57Bl/6 mice. Only the blocking of CD153 led to increased mycobacterial burdens...
  91. ncbi Mechanisms of Mycobacterium avium pathogenesis
    L E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco 94115, USA
    Arch Immunol Ther Exp (Warsz) 48:521-7. 2000
    Infections caused by Mycobacterium avium are common in AIDS patients and patients with chronic lung diseases. The bacterium can be acquired both through the intestinal route and respiratory route. M...
  92. ncbi Epidemiological investigation of a Mycobacterium avium subsp. hominissuis outbreak in swine
    J Alvarez
    VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain
    Epidemiol Infect 139:143-8. 2011
    b>Mycobacterium avium subsp. hominissuis (MAH) infection in swine may cause granulomatous lesions in lymph nodes that must undergo differential diagnosis with those caused by M. tuberculosis complex members...
  93. ncbi Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Antimicrob Chemother 60:1064-73. 2007
    ..Improvement of the efficacy of drug treatment in mycobacterial infection by the development and application of targeted drug delivery...
  94. ncbi Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage activation and apoptosis induction by picolinic acid plus IFNgamma
    Teresa F Pais
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Microbiology 150:1507-18. 2004
    ..of mouse macrophages with picolinic acid (PA) and gamma-interferon (IFNgamma) led to the restriction of Mycobacterium avium proliferation concomitant with the sequential acquisition of metabolic changes typical of apoptosis, ..
  95. ncbi Mitogen-activated protein kinases p38 and ERK1/2 regulated control of Mycobacterium avium replication in primary murine macrophages is independent of tumor necrosis factor-α and interleukin-10
    Kirsten Klug
    Division of Microbial Interface Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Innate Immun 17:470-85. 2011
    ..function on mycobacterial replication from indirect, cytokine-mediated effects, we studied the growth of Mycobacterium avium strains in wild-type and tumor necrosis factor (TNF)-α- or interleukin (IL)-10-deficient bone marrow-..
  96. pmc The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture
    Robert J Greenstein
    Department of Surgery, James J Peters VA Medical Center, Bronx, New York, United States of America
    PLoS ONE 5:e11099. 2010
    ..are increasingly compelling data that another "autoimmune" affliction, Crohn disease, may be caused by Mycobacterium avium subspecies paratuberculosis (MAP). Like M. tb, MAP is systemic...
  97. ncbi Mitogen activated protein kinase p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes
    Cleverson D Souza
    Department of Veterinary and Biomedical Sciences, 1971 Commonwealth Ave, University of Minnesota, St Paul, MN 55108, USA
    Microb Pathog 41:59-66. 2006
    ..p38) pathway on the antimicrobial functions and cytokine expression by bovine monocytes after ingestion of Mycobacterium avium subsp. paratuberculosis...
  98. pmc CD40 is required for the optimal induction of protective immunity to Mycobacterium avium
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Immunology 111:323-7. 2004
    C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40-/-) mice than in control mice...
  99. ncbi NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium
    T Wang
    Department of Microbiology and Molecular Virology, Ohio State University, Columbus, OH 43210, USA
    J Immunol 167:6924-32. 2001
    We have previously reported that Toll-like receptor (TLR) 2 mRNA was induced after infection with Mycobacterium avium. To investigate the molecular basis of TLR2 expression in macrophages, we cloned and analyzed the murine putative 5'-..
  100. ncbi Establishment of Mycobacterium avium subsp. paratuberculosis infection in the intestine of ruminants
    Olöf G Sigurethardóttir
    Department of Pathology, National Veterinary Institute, The Norwegian School of Veterinary Science, P O Box 8156 Dep, 0033 Oslo, Norway
    Adv Drug Deliv Rev 56:819-34. 2004
    b>Mycobacterium avium subsp. paratuberculosis (M. a. paratuberculosis) is the cause of paratuberculosis, which is a chronic enteritis of ruminants characterized by granulomatous inflammation...
  101. ncbi Mycobacterium avium in pygmy rabbits (Brachylagus idahoensis): 28 cases
    Lisa A Harrenstien
    Oregon Zoo, 4001 Southwest Canyon Road Portland, Oregon 97221, USA
    J Zoo Wildl Med 37:498-512. 2006
    ..Disseminated mycobacteriosis due to Mycobacterium avium has been the most common cause of death of adult captive pygmy rabbits...

Research Grants63

  1. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..A specific antigenic stimuli has not been identified, but pathogenic bacteria such as Mycobacterium avium subsp paratuberculosis (MAP) and specific invasive E. coli strains have been proposed...
  2. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..In this proposal, I describe the use of a mouse model of chronic Mycobacterium avium infection to understand changes in HSC function triggered by the innate immune response...
  3. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..shown that one FPR haplotype is associated with a reduced capacity to detect and respond to a peptide from Mycobacterium avium ssp. paratuberculosis...
  4. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lung infections by Mycobacterium avium and Mycobacterium abscessus are increasing in incidence...
  5. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg)and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly those with AIDS...
  6. An integrated NMR/magnetic nanosensor system for detection of bacteria and toxins
    J Manuel Perez; Fiscal Year: 2011
    ..As an intracellular bacterial pathogen model, we will use Mycobacterium avium spp. paratuberculosis (MAP)...
  7. SQ641, new drug candidate to treat NTM infections
    Venkata M Reddy; Fiscal Year: 2010
    b>Mycobacterium avium complex (MAC) and M. abscessus (MAB) are the two most common nontuberculous mycobacteria (NTM) that cause human disease, and the incidence of NTM infections has been increasing worldwide...
  8. Novel preclinical efficacy models against nontuberculosis mycobacteria
    DIANE JOYCE ORDWAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic lung disease due to Mycobacterium avium complex, Mycobacterium chelonae, Mycobacterium abscessus, and Mycobacterium kansasii are an emerging and serious public health problem in the United ..
  9. M. avium GPLs in macrophage activation and virulence
    JEFFREY SCOTT SCHOREY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mycobacterium avium is a major opportunistic pathogen in AIDS patients as well as a major cause of pulmonary infection in individuals with underlying lung disease. However, our understanding of M...
  10. Mathematical and Statistical Modeling of Mycobacterial Disease Control
    REBECCA LEE SMITH; Fiscal Year: 2013
    ..PROPOSAL: Dr. Smith will apply techniques developed for mathematical and statistical models of Mycobacterium avium subsp. paratuberculosis to three other mycobacterial diseases. A model for M...
  11. Genes Associated with Mycobacterium avium Pathogenesis
    LUIZ EDUARDO BERMUDEZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mycobacterium avium causes infection in both immunocompromised patients and in healthy individuals. The chiefly encountered infections are in the respiratory tract, and disseminated...
  12. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2003
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  13. Multiplex TB-M.avium complex Fluorescent in Situ hybridization Assay, direct from
    Jyotsna Shah; Fiscal Year: 2009
    ..in-situ hybridization assay that detects and differentiates Mycobacterium tuberculosis complex (MTB) and Mycobacterium avium complex (MAC) in culture and sputum...
  14. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  15. M. AVIUM DISEASE--INHALED LIPOSOME ANTI-TB DRUG THERAPY
    Hans Schreier; Fiscal Year: 1992
    M. AVIUM DISEASE: INHALED LIPOSOME ANTI-TB DRUG THERAPY. Of the atypical mycobacteria, the Mycobacterium avium-intracellular complex (MAIC) is the most common human pathogen...
  16. DICATIONIC DRUGS--TREATMENT FOR AIDS-RELATED INFECTIONS
    Richard Tidwell; Fiscal Year: 1999
    ..several other important AIDS related pathogens including: Cryptococcus neoformans, Cryptosporidium parvum, Mycobacterium avium, Toxoplasma gondii, Mycobacterium tuberculosis, and Candida albicans. Together with P...
  17. MYCOBACTERIAL CELL WALL AND DRUG DISCOVERY
    Patrick Brennan; Fiscal Year: 2007
    ..of the pyruvic[unreadable] acid-containing "C-mycoside" glycopeptidolipid (GPL) antigens of the[unreadable] Mycobacterium avium/Mycobacterium intracellulare/Mycobacterium scrofulaceum[unreadable] complex will continue in concert with a ..
  18. M AVIUM IMMUNE RESPONSES--IMPLICATIONS FOR THERAPY
    W Boom; Fiscal Year: 1999
    Disseminated Mycobacterium avium complex (MAC) infection is the most common bacterial opportunistic complication in patients with AIDS...
  19. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2005
    ..of Chronic Diseases: Novel Approaches to Pathogen Detection" and specifically addresses the study of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis). M...
  20. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2003
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  21. Target for Mefloquine in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2002
    ..Mycobacterium tuberculosis and Mycobacterium avium are intracellular pathogens that infect both healthy individuals and immunocompromised patients. M...
  22. RESISTANCE OF OPPORTUNISTIC INFECTION BY MYCOBACTERIA
    D Blanchard; Fiscal Year: 1992
    b>Mycobacterium avium-intracellulare (MAI) is an atypical mycobacterium commonly found in the environment which rarely causes invasive disease in humans in the absence of a pre-existing condition...
  23. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2007
    ..Many occur in bacteria pathogenic to man (e.g. Mycobacterium tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, ..
  24. CELL BIOLOGY OF MYCOBACTERIUM AVIUM INFECTION
    Eric Brown; Fiscal Year: 2002
    This is a program project to study the cell biology of Mycobacterium avium complex (MAC) infection...
  25. INFECTION MODEL OF LEPROMATOUS LEPROSY
    Frank Collins; Fiscal Year: 1991
    b>Mycobacterium avium-complex can produce progressive systemic infections in susceptible strains of mice (C57BL/6 or BALB/c) which resemble human lepromatous leprosy, providing a convenient experimental model with which to study the ..
  26. Targeting M. tuberculosis alanine ligase for drug design
    RAUL BARLETTA; Fiscal Year: 2003
    ..M. tuberculosis, along with Mycobacterium avium,, is a major opportunistic pathogen of AIDS patients...
  27. The Role of SP-A in Pulmonary Host Defense
    VIRGINIA SHEPHERD; Fiscal Year: 2004
    ..We have shown in preliminary studies that Mycobacterium bovis BCG and Mycobacterium avium internalization by macrophages is enhanced by opsonization with SP-A...
  28. MULTIDRUG RESISTANT MORPHOTYPIC VARIANTS OF M. AVIUM
    Gerard Cangelosi; Fiscal Year: 2003
    b>Mycobacterium avium is responsible for serious opportunistic infections of AIDS patients and other susceptible individuals. M...
  29. Molecular Analysis of Microbes in Chronic Bowel Disease
    Norman Pace; Fiscal Year: 2004
    ..Although some evidence suggests that Mycobacterium avium ssp...
  30. VACCINIA VIRUS DNA TOPOISOMERASE
    Stewart Shuman; Fiscal Year: 2006
    ..Among the bacteria that encode type IB topos are Mycobacterium avium and Pseudomonas aeruginosa ,which cause significant disease in humans...
  31. Ethanol-fed, CpG-treated mice: Listeria susceptibility
    Nancy Ray; Fiscal Year: 2005
    ..Because defects in killing Mycobacterium avium, an intracellular bacteria similar to L...
  32. STRUCTURE OF THE ANTIGENS OF ATYPICAL MYCOBACTERIA
    Patrick Brennan; Fiscal Year: 1980
    The complete structures of the surface antigens from 5 of the 31 serovars in the Mycobacterium avium-M. intracellulare-M. scrofulaceum (MAIS) complex have been established...
  33. SECONDARY ILLNESS AND THE WASTING OF AIDS
    Carl Grunfeld; Fiscal Year: 1999
    ..intake, improve with the successful treatment of secondary infections; 2) to determine whether treatment of mycobacterium avium complex results in similar improvements in energy balance since sterilization of bacteria is not always ..
  34. MYCOBACTERIUM AVIUM--MECHANISMS OF IRON ACQUISITION
    RANDALL LAMBRECHT; Fiscal Year: 1992
    ..applicant's abstract): The overall goal of this project is to elucidate the role of iron acquisition by Mycobacterium avium complex (MAC) organisms in the intracellular survival of these mycobacteria...
  35. Structural Studies of the MPT64 Family of Mycobacterial Virulence Factors
    BRIAN GEISBRECHT; Fiscal Year: 2007
    ..by solving the high-resolution crystal structure of MAP0087, 1of 2 family members found in the genome of Mycobacterium avium subsp. paratuberculosis (Map)...
  36. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..One of the proposed etiologies is infection with Mycobacterium avium subsp. paratuberculosis (M...
  37. MOLECULAR EPIDEMIOLOGY OF MYCOBACTERIUM AVIUM
    Vivek Kapur; Fiscal Year: 2000
    DESCRIPTION (adapted from the Abstract): In the United States, infection with Mycobacterium avium is the most common disease of bacterial origin among patients with the acquired immunodeficiency syndrome (AIDS)...
  38. HIV INFECTION IN THE SCID-HU MOUSE
    Joseph McCune; Fiscal Year: 1993
    Disseminated Mycobacterium avium complex (MAC) is the most common bacterial infection in patients with the acquired immunodeficiency syndrome (AIDS)...
  39. MOLECULAR MECHANISMS OF MAVIUM COMPLEX PATHOGENESIS
    VENKATA REDDY; Fiscal Year: 2001
    b>Mycobacterium avium complex (MAC) group of organisms, which are ubiquitous in nature, are the most common opportunistic bacterial pathogens seen in AIDS...
  40. Nontuberculous Mycobacteria Research Consortium
    Charles Daley; Fiscal Year: 2006
    ..b>Mycobacterium avium complex (MAC) accounts for over 75% of the pulmonary infections due to NTM...
  41. Gamma-delta T cell function in mycobacterial infection
    FRANK SIMUTIS; Fiscal Year: 2004
    ..role for gamma-delta T cells in macrophage activation and bactericidal activity during early infection with Mycobacterium avium subsp. paratuberculosis (Map)...
  42. INTRACELLULAR SURVIVAL OF MYCOBACTERIUM AVIUM COMPLEX
    David Russell; Fiscal Year: 1993
    ..The combination of biochemical, cell biological, and immunological approaches described in this project is supported by strong collaborations, and the results should enhance our understanding of intracellular MAC infections...
  43. NORTH JERSEY COMMUNITY RESEARCH INITIATIVE (NJCRI)
    George Perez; Fiscal Year: 2006
    ..Ritonavir (NvR) study, they will enroll 50 patients in Mycobacterium avium complex (CR-MAC) and 50 in Pneumococcal Resistance...
  44. Influence of SIV gp120 on Mycobacterial Pathogenesis
    ELIZABETH HENDRICKS; Fiscal Year: 2004
    ..composition of hepatic microgranulomas from rhesus macaques experimentally infected with SIV and Mycobacterium avium; Aim 2: Determine the effects of gp120 interaction with chemokine receptors on macrophage signal ..
  45. COMPLEMENT AND OPPORTUNISTIC MYCOBACTERIA IN AIDS
    MARCUS HORWITZ; Fiscal Year: 1990
    ..Infections with Mycobacterium tuberculosis and Mycobacterium avium-intracellular (MAI) are particularly important...
  46. ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM FOR AIDS
    Joseph Eron; Fiscal Year: 2006
    ..Patients will be followed for in vivo evidence of study drug effects on HIV, Mycobacterium avium intracellular complex (MAC), cytomegalovirus (CMV), herpes simplex virus (HSV), and other opportunistic ..
  47. EVAL OF THERAPIES FOR MYCOBACTERIUM AVIUM INFECOTION
    LOWELL YOUNG; Fiscal Year: 2000
    ..systems will provide the NIAID with testing capabilities to evaluate therapies for treatment against Mycobacterium avium, both singly and in combination...
  48. RESYNTHESIS OF POTENTIAL THERAPEUTIC AGENTS
    JUROSLOV NOVOTNY; Fiscal Year: 1999
    ..g. Pneumocystis carinii,Mycobacterium avium complex, Toxoplasma gondii, etc) associated with AIDS...
  49. TAS::75 0885::TAS EFFICACY OF ORAL AMINOGLYCOSIDE-COCHLEATE FORMULATIONS
    BONITZ SUSAN; Fiscal Year: 2010
    The long term goal of this project is to prepare cochleate formulations of aminoglycosides that will demonstrate efficacious oral bioavailability and reduced toxicity in animal models of Mycobacterium avium.
  50. THE MYCOBACTERIAL STRINGENT RESPONSE
    TODD PRIMM; Fiscal Year: 2002
    ..Species of the Mycobacterium avium complex (MAC) infect half of AIDS patients, significantly increasing morbidity and mortality...
  51. TITLE OMITTED
    Lawrence Johnson; Fiscal Year: 1991
    ..involve mice infected with: Pneumocystis carinii, Cryptococcus neoformans, Mycobacterium tuberculosis, Mycobacterium avium and Listeria monocytogenes...
  52. MYCOBACTERIUM AVIUM MECHANISMS OF PATHOGENESIS
    JOSEPHINE CLARK CURTISS; Fiscal Year: 1999
    ..avium bacilii. ..
  53. Mycobacterium avium-phagocyte interactions in a murine infection model
    TODD PRIMM; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Mycobacterium avium (M. avium) is an environmental organism causing opportunistic infections in man and animals of agricultural importance. M...
  54. MYCOBACTERIAL DISEASES IN AIDS
    Jerrold Ellner; Fiscal Year: 2001
    b>Mycobacterium avium is the most frequent cause of disseminated bacterial infection in patients infected with human immunodeficiency virus (HIV) and is associated with morbidity and shortened survival. It is not clear why M...
  55. COMPLETE SEQUENCING AND GENE EXPRESSION IN M AVIUM
    Robert Fleischmann; Fiscal Year: 1999
    ..from Applicant,s Abstract) The goals of this project are to determine the complete DNA sequence of the Mycobacterium avium chromosome and examine global changes in gene expression with various changes in environmental conditions ..
  56. MYCOBACTERIUM AVIUM DNA B AND NOVEL DRUG TARGET
    Murty Madiraju; Fiscal Year: 2002
    ..avium DNA replication and metabolism. The long term goal is to be able to develop drugs that will block the initiation process and thereby prevent growth and development of M.avium infections. ..
  57. INHALED CYTOKINES FOR MYCOBACTERIAL LUNG DISEASE
    Antonino Catanzaro; Fiscal Year: 1999
    Although nontuberculous mycobacteria (NTM), such as Mycobacterium avium-intracellulare complex (MAC), are ubiquitous in the environment, disease caused by NTM is rare in immunocompetent hosts...
  58. Antimicrobial Peptides in Resistance to Tuberculosis
    Kevin Kisich; Fiscal Year: 2002
    Infections with drug resistant strains of Mycobacterium tuberculosis and most strains of Mycobacterium avium are challenging to treat chemotherapeutically...
  59. DEFECTS IN NATIVE ANTI-M AVIUM IMMUNITY IN AIDS
    GEORGE DOUVAS; Fiscal Year: 1992
    Severe infection with Mycobacterium avium is an undesirable, so-far incurable, complication of HIV infection in up to 50% of AIDS patients. This project's objective is to learn why AIDS patients are extraordinarily susceptible to M...
  60. Post Translation Regulation in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2008
    ..b>Mycobacterium avium and M. tuberculosis interact with the host mucosa (s) at the initial stages of the infection...
  61. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2003
    b>Mycobacterium avium and Mycobacterium tuberculosis are intracellular pathogens that infect mononuclear phagocytes and survive within tissue macrophages. Tuberculosis is responsible for millions of deaths annually, and M...
  62. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  63. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....