mycobacterium avium

Summary

Summary: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.

Top Publications

  1. pmc Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection
    Jutta Sharbati
    Institute of Veterinary Biochemistry, Freie Universitaet Berlin, Berlin, Germany
    PLoS ONE 6:e20258. 2011
  2. pmc Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 282:25779-89. 2007
  3. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011
  4. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
  5. ncbi Molecular evidence to support a proposal to reserve the designation Mycobacterium avium subsp. avium for bird-type isolates and 'M. avium subsp. hominissuis' for the human/porcine type of M. avium
    Wouter Mijs
    Innogenetics N V, Ghent, Belgium
    Int J Syst Evol Microbiol 52:1505-18. 2002
  6. ncbi Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni
    Randy Sacco
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Immunol 104:274-81. 2002
  7. ncbi A comparison of ovine monocyte-derived macrophage function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
    Sven T Berger
    Disease Research Laboratory, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 84:349-56. 2006
  8. ncbi The distribution of Mycobacterium avium ssp. paratuberculosis in the environment surrounding Minnesota dairy farms
    E A Raizman
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, MN 55455, USA
    J Dairy Sci 87:2959-66. 2004
  9. ncbi Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues
    M Moravkova
    Veterinary Research Institute Brno, Department of Food and Feed Safety, Hudcova 70, 621 32 Brno, Czech Republic
    Res Vet Sci 85:257-64. 2008
  10. pmc Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 116:3485-93. 2010

Research Grants

  1. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
  2. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2004
  3. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2003
  4. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2002
  5. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2010
  6. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 1999
  7. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2002
  8. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2000
  9. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2001
  10. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2003

Detail Information

Publications302 found, 100 shown here

  1. pmc Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection
    Jutta Sharbati
    Institute of Veterinary Biochemistry, Freie Universitaet Berlin, Berlin, Germany
    PLoS ONE 6:e20258. 2011
    ..Therefore, we present a comprehensive study for identification of these key regulators and their targets in the context of host macrophage response to mycobacterial infections...
  2. pmc Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 282:25779-89. 2007
    b>Mycobacterium avium is a major opportunistic pathogen in HIV-positive individuals and is responsible for increased morbidity and mortality in AIDS patients. M...
  3. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011
    To investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium, TLR9, TLR2, and MyD88 knockout (KO) mice were infected with this bacterium...
  4. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
    b>Mycobacterium avium subsp hominissuis (previously Mycobacterium avium subsp avium) is an environmental organism associated with opportunistic infections in humans...
  5. ncbi Molecular evidence to support a proposal to reserve the designation Mycobacterium avium subsp. avium for bird-type isolates and 'M. avium subsp. hominissuis' for the human/porcine type of M. avium
    Wouter Mijs
    Innogenetics N V, Ghent, Belgium
    Int J Syst Evol Microbiol 52:1505-18. 2002
    In an attempt to clarify the taxonomy of the Mycobacterium avium complex, the relationship between IS1245 RFLP, growth temperature, 16S rDNA signature sequences and the 16S-23S rDNA internally transcribed spacer (ITS) of 160 M...
  6. ncbi Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni
    Randy Sacco
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Immunol 104:274-81. 2002
    b>Mycobacterium avium established a systemic infection with granulomatous inflammation in mice. Mice chronically infected with M...
  7. ncbi A comparison of ovine monocyte-derived macrophage function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
    Sven T Berger
    Disease Research Laboratory, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 84:349-56. 2006
    b>Mycobacterium avium ssp. paratuberculosis causes Johne's disease in ruminants, whereas the antigenically and genetically similar subspecies Mycobacterium avium ssp. avium is less virulent...
  8. ncbi The distribution of Mycobacterium avium ssp. paratuberculosis in the environment surrounding Minnesota dairy farms
    E A Raizman
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, MN 55455, USA
    J Dairy Sci 87:2959-66. 2004
    ..The study results indicate that targeted sampling of cow alleyways and manure storage areas appears to be an alternative strategy for herd screening and Johne's infection status assessment and for estimating herd fecal prevalence...
  9. ncbi Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues
    M Moravkova
    Veterinary Research Institute Brno, Department of Food and Feed Safety, Hudcova 70, 621 32 Brno, Czech Republic
    Res Vet Sci 85:257-64. 2008
    The members of Mycobacterium avium species, comprising M. avium subsp. paratuberculosis, M. a. hominissuis, M. a. avium, M. a...
  10. pmc Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice
    Daniel L Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 116:3485-93. 2010
    ..Here, we show that Mycobacterium avium-infected T cell-deficient mice injected with CD4 T cells also develop an immune reconstitution disease (IRD)..
  11. ncbi Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis
    Judith T Murphy
    Center for Animal Functional Genomics and Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
    Physiol Genomics 28:67-75. 2006
    b>Mycobacterium avium subspecies paratuberculosis (MAP) and Mycobacterium avium subspecies avium (MAA) represent two closely related intracellular bacteria with vastly different associated pathologies...
  12. pmc Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Center for Medicine and Biosciences, D 23845 Borstel, Germany
    J Exp Med 194:1847-59. 2001
    ..Aerosol infection in mice with the highly virulent Mycobacterium avium strain TMC724 causes progressive pulmonary pathology strongly resembling caseating necrosis in human ..
  13. ncbi Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis
    S Aly
    Division of Molecular Infection Biology, Research Centre Borstel, D 23845 Borstel, Germany
    J Pathol 212:295-305. 2007
    ..Lung histopathology of C57BL/6 (WT) mice 16 weeks after aerosol infection with Mycobacterium avium strain TMC724 is uniquely characterized by centrally necrotizing granulomas, strongly resembling human TB ..
  14. pmc IS1245 restriction fragment length polymorphism typing of Mycobacterium avium isolates: proposal for standardization
    D van Soolingen
    Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 36:3051-4. 1998
    b>Mycobacterium avium has become a major human pathogen, primarily due to the emergence of the AIDS epidemic...
  15. ncbi Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subsp. avium infections in a tule elk (Cervus elaphus nannodes) herd
    Graham C Crawford
    Wildlife Health Center, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, California 95616, USA
    J Wildl Dis 42:715-23. 2006
    ..were identified by a multiplex polymerase chain reaction (PCR) that discriminates among members of the Mycobacterium avium complex (MAC)...
  16. ncbi A major cell wall lipopeptide of Mycobacterium avium subspecies paratuberculosis
    Torsten M Eckstein
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 281:5209-15. 2006
    b>Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne disease in cattle and other ruminants, is proposed to be at least one of the causes of Crohn disease in humans...
  17. pmc Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium
    Dharshini Jeevarajah
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Bacteriol 186:6792-9. 2004
    ..Four methyltransferases have been implicated in the synthesis of the GPLs of Mycobacterium smegmatis and Mycobacterium avium. A rhamnosyl 3-O-methytransferase and a fatty acid methyltransferase of M...
  18. pmc Natural occurrence of horizontal transfer of Mycobacterium avium- specific insertion sequence IS1245 to Mycobacterium kansasii
    Michelle Christiane da Silva Rabello
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu, 862 3 degrees andar, 04023 062 Sao Paulo, SP, Brazil
    J Clin Microbiol 48:2257-9. 2010
    Mycobacterium kansasii carrying IS1245, a highly prevalent insertion sequence among Mycobacterium avium isolates, was detected in a mixed culture of M. avium and M. kansasii...
  19. pmc Prevalence of Mycobacterium avium in slaughter pigs in The Netherlands and comparison of IS1245 restriction fragment length polymorphism patterns of porcine and human isolates
    R E Komijn
    National Inspection Service for Livestock and Meat, 2270 JA Voorburg, The Netherlands
    J Clin Microbiol 37:1254-9. 1999
    ..In a follow-up study, Mycobacterium avium complex (MAC) bacteria were isolated from 219 of 402 affected lymph nodes (54.2%)...
  20. ncbi Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. avium
    Franck Biet
    UR1282, Infectiologie Animale, Santé Publique, INRA Centre de Tours, F 37380 Nouzilly, France
    Vaccine 26:257-68. 2008
    ..These surface-located GPLs are involved in pathogenicity by interfering with the host immune system. In Mycobacterium avium subsp...
  21. doi Multiple strains of Mycobacterium avium subspecies hominissuis infections associated with aborted fetuses and wasting in pigs
    G J Wellenberg
    Animal Health Service GD Deventer, 7400 AA, Deventer, The Netherlands
    Vet Rec 167:451-4. 2010
    ..The specimen cultures were identified as Mycobacterium avium subspecies hominissuis using IS1245-specific PCR and IS1245 restriction fragment length polymorphism (RFLP)...
  22. pmc Investigation of an outbreak of mycobacteriosis in pigs
    Angelika Agdestein
    Norwegian Veterinary Institute, N 0106 Oslo, Norway
    BMC Vet Res 7:63. 2011
    ..An investigation of potential mycobacteriosis in the pigs imported to Serbia and the possible source of infection in the Lithuanian herd were therefore initialised...
  23. ncbi Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104
    J B Torrelles
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 82:293-300. 2002
    Members of the Mycobacterium avium complex (MAC) are responsible for mycobacterial disease in children, the aged and in immunocompromised individuals...
  24. ncbi Comparison of three DNA extraction methods for Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium subsp. avium
    A Amaro
    Laboratório Nacional de Investigação Veterinária, Lisboa, Portugal
    Lett Appl Microbiol 47:8-11. 2008
    To compare three methods for DNA extraction from Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium subsp. avium.
  25. ncbi Optimization of electroporation conditions for Mycobacterium avium
    S H Lee
    Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
    Tuberculosis (Edinb) 82:167-74. 2002
    Successful transformation and subsequent genetic manipulation of Mycobacterium avium requires suitable vectors, efficient transformation systems, and reliable selectable markers...
  26. doi Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily
    Jeng Yeong Chow
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore
    Biochemistry 48:4344-53. 2009
    ..Using a quorum-quenching lactonase from Mycobacterium avium subsp...
  27. pmc Mutational analysis of cell wall biosynthesis in Mycobacterium avium
    Jean Pierre Laurent
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Bacteriol 185:5003-6. 2003
    The cell wall of the environmental pathogen Mycobacterium avium is important to its virulence and intrinsic antimicrobial resistance...
  28. doi Real-time quantitative PCR detection of Mycobacterium avium subspecies in meat products
    B Klanicova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    J Food Prot 74:636-40. 2011
    The aim of this work was to examine various purchased meat products and to find out if any traces of Mycobacterium avium subsp. avium, M. avium subsp. hominissuis, and M. avium subsp. paratuberculosis could be detected in these samples...
  29. ncbi Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium
    Cleverson D Souza
    Department of Veterinary Science, University of Minnesota, St Paul, MN 55108, USA
    Microbes Infect 9:1545-52. 2007
    ..of activation and antimicrobial activities of MAPK-p38 and MAPK-ERK in bovine monocytes infected with Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium avium subsp. avium (Maa)...
  30. pmc Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms
    Yong Jun Li
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Med Microbiol 59:8-16. 2010
    b>Mycobacterium avium is an opportunistic pathogen associated with pulmonary disease in non-AIDS patients and disseminated infection in patients with AIDS...
  31. ncbi Optimization of methods for detecting Mycobacterium avium subsp. paratuberculosis in environmental samples using quantitative, real-time PCR
    Kimberly L Cook
    AWMRU, USDA ARS, 230 Bennett Lane, Bowling Green, KY 42104, USA
    J Microbiol Methods 69:154-60. 2007
    Detection of Johne's disease, an enteric infection of cattle caused by Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis), has been impeded by the lack of rapid, reliable detection methods...
  32. pmc Molecular characterization of pigmented and nonpigmented isolates of Mycobacterium avium subsp. paratuberculosis
    Karen Stevenson
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, United Kingdom
    J Clin Microbiol 40:1798-804. 2002
    Five pigmented isolates of Mycobacterium avium subsp. paratuberculosis were examined by pulsed-field gel electrophoresis (PFGE), IS900 restriction fragment length polymorphism (IS900-RFLP), and IS1311 polymorphism analysis using PCR...
  33. ncbi Apoptosis of CD4+ and CD8+ T cells during experimental infection with Mycobacterium avium is controlled by Fas/FasL and Bcl-2-sensitive pathways, respectively
    Jie Zhong
    Department of Microbiology and Immunology, University of Melbourne, Australia
    Immunol Cell Biol 81:480-6. 2003
    Both CD4+ and CD8+ T cells from mice infected with Mycobacterium avium suffered a high rate of apoptosis, beginning with the onset of the immune response and culminating in the loss of T cells from the tissues and loss of IFN-gamma ..
  34. pmc A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen
    Marcela Parra
    Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 74:786-9. 2006
    Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited...
  35. ncbi Mycobacterial interspersed repetitive units (MIRU) differentiate Mycobacterium avium subspecies paratuberculosis from other species of the Mycobacterium avium complex
    T J Bull
    Department of Surgery, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Mol Cell Probes 17:157-64. 2003
    ..We have identified MIRU at 18 conserved loci throughout the common portions of the Mycobacterium avium subspecies paratuberculosis (MAP) and M. avium subspecies avium (MAA) genomes...
  36. pmc Short-sequence-repeat analysis of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium isolates collected from animals throughout the United States reveals both stability of loci and extensive diversity
    N Beth Harris
    National Veterinary Services Laboratories, Ames, IA 50010, USA
    J Clin Microbiol 44:2970-3. 2006
    We analyzed the multilocus short sequence repeats (SSRs) of 211 and 56 isolates of Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium, respectively. The M. avium subsp...
  37. ncbi Recombinant interleukin-4-treated macrophages, epithelioid cell surrogates, harbor and arrest Mycobacterium avium multiplication in vitro
    Ludmilla T D Chinen
    Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Rua Botucatu 862, 4th andar, Vila Clementino, 04023 900 São Paulo, Brazil
    Microbes Infect 8:965-73. 2006
    ..T-cell lymphoproliferation assays using ovalbumin (OVA) and Mycobacterium avium as antigens showed that both cultured macrophages were equally efficient as antigen presenting cells (APCs)...
  38. doi IS1245 RFLP-based genotyping study of Mycobacterium avium subsp. hominissuis isolates from pigs and humans
    Mateja Pate
    University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbiceva 60, 1115 Ljubljana, Slovenia
    Comp Immunol Microbiol Infect Dis 31:537-50. 2008
    b>Mycobacterium avium subsp. hominissuis, ubiquitous environmental mycobacterium, is an opportunistic pathogen that is regularly isolated from pigs and humans in Slovenia...
  39. pmc New variable-number tandem-repeat markers for typing Mycobacterium avium subsp. paratuberculosis and M. avium strains: comparison with IS900 and IS1245 restriction fragment length polymorphism typing
    Virginie C Thibault
    UR1282, Infectiologie Animale, Santé Publique IASP 311, INRA Centre de Tours, F 37380 Nouzilly, France
    J Clin Microbiol 45:2404-10. 2007
    b>Mycobacterium avium subsp. paratuberculosis, the etiological agent of paratuberculosis, affects a wide range of domestic ruminants and has been suggested to be involved in Crohn's disease in humans...
  40. ncbi Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages
    Sushil Kumar Pathak
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Calcutta 700009, India
    J Biol Chem 279:55127-36. 2004
    ..Our studies demonstrate that the NF-kappaB and CRE elements of the COX-2 promoter are critical to Mycobacterium avium-induced COX-2 gene expression. M. avium-triggered signaling originates at the Toll-like receptor 2 (TLR2)...
  41. pmc Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase
    T Hayashi
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 69:6156-64. 2001
    ..Based on these activities, we investigated whether ISS-ODN could modify the course of Mycobacterium avium infection. M...
  42. pmc The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria
    Stephan Schmitz-Esser
    Department of Microbial Ecology, University of Vienna, Vienna, Austria
    J Bacteriol 192:1045-57. 2010
    ..bacteria (including chlamydiae, Legionella pneumophila, Rickettsia bellii, Francisella tularensis, and Mycobacterium avium)...
  43. pmc Regulation of expression of major histocompatibility antigens by bovine macrophages infected with Mycobacterium avium subsp. paratuberculosis or Mycobacterium avium subsp. avium
    D J Weiss
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    Infect Immun 69:1002-8. 2001
    b>Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium are antigenically and genetically very similar organisms; however, they differ markedly in their virulence for cattle...
  44. ncbi Lateral gene transfer in Mycobacterium avium subspecies paratuberculosis
    Pradeep Reddy Marri
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Can J Microbiol 52:560-9. 2006
    ..Here, we report instances of lateral gene transfer in Mycobacterium avium subsp. paratuberculosis, a pathogenic bacteria that causes Johne's disease in cattle...
  45. pmc Whole-genome plasticity among Mycobacterium avium subspecies: insights from comparative genomic hybridizations
    Chia Wei Wu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706 1581
    J Bacteriol 188:711-23. 2006
    Infection with Mycobacterium avium subsp. paratuberculosis causes Johne's disease in cattle and is also implicated in cases of Crohn's disease in humans. Another closely related strain, M. avium subsp...
  46. pmc Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts
    Monica Hagedorn
    Departement de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Science 323:1729-33. 2009
    ..This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells...
  47. pmc Susceptibility of beige mice to Mycobacterium avium: role of neutrophils
    R Appelberg
    Centro de Citologia Experimental, University of Porto, Portugal
    Infect Immun 63:3381-7. 1995
    The beige mutation in C57BL/6 mice has been shown to increase the susceptibility to infection by Mycobacterium avium. In this study, we confirmed those results and showed that the effect of the beige mutation was most obvious after ..
  48. ncbi Causation of Crohn's disease by Mycobacterium avium subspecies paratuberculosis
    J Hermon-Taylor
    St George s Hospital Medical School, London, United Kingdom
    Can J Gastroenterol 14:521-39. 2000
    b>Mycobacterium avium subspecies paratuberculosis (MAP) is a member of the M avium complex (MAC)...
  49. ncbi Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner
    Lindsay Sweet
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    J Leukoc Biol 80:415-23. 2006
    ..susceptible to infection by Mycobacterium tuberculosis, Mycobacterium bovis bacillus Calmette-Guerin, and Mycobacterium avium. Therefore, it is important to define the molecules expressed by pathogenic mycobacteria, which bind the ..
  50. doi Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis
    Liliana Rodrigues
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    J Antimicrob Chemother 61:1076-82. 2008
    Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M...
  51. pmc Comparative genomic analysis of Mycobacterium avium subspecies obtained from multiple host species
    Michael L Paustian
    National Animal Disease Center, USDA ARS, Ames, USA
    BMC Genomics 9:135. 2008
    b>Mycobacterium avium (M. avium) subspecies vary widely in both pathogenicity and host specificity, but the genetic features contributing to this diversity remain unclear.
  52. ncbi Modulation of eukaryotic cell apoptosis by members of the bacterial order Actinomycetales
    Daniel P Barry
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
    Apoptosis 11:1695-707. 2006
    ..Rather than covering the entire field, this review focuses on the dysregulation of host cell apoptosis by members of the order Actinomycetales, containing the genera Corynebacterium, Mycobacterium, Rhodococcus, and Nocardia...
  53. pmc A novel enzyme-linked immunosorbent assay for diagnosis of Mycobacterium avium subsp. paratuberculosis infections (Johne's Disease) in cattle
    C A Speer
    Center for Wildlife Health, Department of Forestry, Wildlife and Fisheries, The University of Tennessee, P O Box 1071, Knoxville, TN 37901 1071, USA
    Clin Vaccine Immunol 13:535-40. 2006
    Enzyme-linked immunosorbent assays (ELISAs) for the diagnosis of Johne's disease (JD), caused by Mycobacterium avium subsp...
  54. doi Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium
    J M Garrido
    NEIKER Tecnalia, Animal Health Department, 48160 Derio, Bizkaia, Spain
    Vet Microbiol 144:240-5. 2010
    ..We aimed to characterize the first experimental Mycobacterium avium subsp...
  55. ncbi Survival of Mycobacterium avium in a model distribution system
    Cheryl D Norton
    American Water, Quality Control and Research Laboratory, 1115 South Illinois Street, Belleville, IL 62220, USA
    Water Res 38:1457-66. 2004
    ..avium complex in drinking water biofilms...
  56. ncbi Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination
    David K Flaherty
    Department of Internal Medicine, Division of Infectious Diseases, Center for Microbial Interface Biology, 420 West 12th Avenue, Columbus, OH 43210, USA
    J Leukoc Biol 80:1262-71. 2006
    ..Mice were vaccinated with BCG and subsequently given repeated oral doses of live Mycobacterium avium to model exposure to environmental mycobacteria...
  57. doi Isolation of mycobacteria other than Mycobacterium avium from porcine lymph nodes
    Jakko van Ingen
    National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vet Microbiol 144:250-3. 2010
    b>Mycobacterium avium causes lymphadenitis in pigs. This presents an economical burden, as these pigs meat is considered inappropriate for consumption...
  58. pmc Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium
    M S Gomes
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Portugal
    Immunology 95:165-8. 1998
    In the mouse, the progression of the Mycobacterium avium infection is highly dependent on the Nramp1 gene. Strains of mice that express the Nramp1D169 allele are highly susceptible to M...
  59. doi Mycobacterium avium in a shower linked to pulmonary disease
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    J Water Health 6:209-13. 2008
    b>Mycobacterium avium was isolated from hot and cold water samples and from sediment (biofilm) collected from the showerhead in the home of a woman with M. avium pulmonary disease lacking known M. avium risk factors...
  60. ncbi Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor
    S Hussain
    Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210, USA
    J Immunol 163:2041-8. 1999
    ..the expression of a panel of IFN-gamma-inducible genes and activation of Janus Kinase (JAK)-STAT pathway in Mycobacterium avium-infected macrophages...
  61. pmc Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids
    Lindsay Sweet
    Department of Biological Sciences, Eck Institute for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Infect Immun 78:518-26. 2010
    ..that phagosomes containing silica beads coated with glycopeptidolipids (GPLs), a major surface component of Mycobacterium avium, showed limited acidification and delayed recruitment of late endosomal/lysosomal markers compared to those ..
  62. ncbi Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens
    Lawrence Broxmeyer
    Med America Research, Whitestone, New York, USA
    J Infect Dis 186:1155-60. 2002
    b>Mycobacterium avium causes disseminated infection in patients with acquired immune deficiency syndrome. Mycobacterium tuberculosis is a pathogen associated with the deaths of millions of people worldwide annually...
  63. pmc Mycobacterium avium in the postgenomic era
    Christine Y Turenne
    McGill University Health Centre, A5 156, 1650 Cedar Avenue, Montreal H3G 1A4, Canada
    Clin Microbiol Rev 20:205-29. 2007
    The past several years have witnessed an upsurge of genomic data pertaining to the Mycobacterium avium complex (MAC)...
  64. pmc Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
    Oyvind Halaas
    Department of Cancer Research and Molecular Medicine, Norges Teknisk Naturvitenskapelige Universitet, and St Olavs Hospital, Trondheim, Norway
    J Infect Dis 201:783-92. 2010
    ..Here we show that Lcn2 suppressed growth of Mycobacterium avium in culture, and M. avium induced Lcn2 production from mouse macrophages...
  65. doi PCR analysis of the presence and location of Mycobacterium avium in a constructed reed bed, with implications for avian tuberculosis control
    Julian A Drewe
    Institute of Zoology, Zoological Society of London, London, UK
    FEMS Microbiol Ecol 67:320-8. 2009
    ..Particular emphasis was placed on the presence and location of Mycobacterium avium--the causal agent of avian tuberculosis (ATB)--in an effort to clarify the potential role of reed beds in ..
  66. ncbi Isolation and characterisation of Mycobacterium avium and Rhodococcus equi from granulomatous lesions of swine lymph nodes in Slovenia
    Mateja Pate
    Institute of Microbiology and Parasitology, Veterinary Faculty Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia
    Acta Vet Hung 52:143-50. 2004
    ..b>Mycobacterium avium alone was isolated in 47.3% of pigs and in mixed infection with Rhodococcus equi in 3.9% of pigs. R...
  67. ncbi Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis
    Martin Feller
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Lancet Infect Dis 7:607-13. 2007
    This systematic review assesses the evidence for an association between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease...
  68. doi Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity
    M Salomé Gomes
    Laboratory of Microbiology and Immunology of Infection, IBMC Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
    Eur J Immunol 38:2180-9. 2008
    ..immune response to mycobacterial infections, being required for optimal immunity against certain virulent Mycobacterium avium strains. Here we analyzed the role of TLR2 in the intra-macrophagic growth of M...
  69. ncbi Serotype-specific modulation of human monocyte functions by glycopeptidolipid (GPL) isolated from Mycobacterium avium complex
    Hideyuki Kano
    Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara 228 8555, Japan
    Biol Pharm Bull 28:335-9. 2005
    Immunomodulating activity of glycopeptidolipids (GPL), separated from different serovars of Mycobacterium avium complex (MAC), on macrophage functions was compared...
  70. pmc Impaired host defence against Mycobacterium avium in mice with chronic granulomatous disease
    M Fujita
    Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 160:457-60. 2010
    ..To determine whether or not NADPH oxidase is crucial to the host defence against Mycobacterium avium, we investigated the response against M. avium using CGD model mice (gp91-phox(-)) of C57BL/6 strain...
  71. ncbi Different immune response of pigs to Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis infection
    Hana Stepanova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Vet Microbiol 159:343-50. 2012
    b>Mycobacterium avium subsp. avium (MAA) and Mycobacterium avium subsp. hominissuis (MAH) are the most common mycobacterial species isolated from granulomatous lesions in swine in countries with controlled bovine tuberculosis...
  72. pmc Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways
    Melanie J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    J Bacteriol 191:1132-42. 2009
    The Mycobacterium avium complex (MAC) is an important group of opportunistic pathogens for birds, cattle, swine, and immunosuppressed humans...
  73. ncbi Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages
    G F Schiavano
    Institute of Hygiene, University of Urbino, 61029, Urbino, Italy
    Int J Antimicrob Agents 18:525-30. 2001
    ..with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of Mycobacterium avium. Overall, clarithromycin-ethambutol-rifampicin was the most active combination tested...
  74. ncbi Elevated mitogen-activated protein kinase signalling and increased macrophage activation in cells infected with a glycopeptidolipid-deficient Mycobacterium avium
    Sanchita Bhatnagar
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    Cell Microbiol 8:85-96. 2006
    b>Mycobacterium avium is a significant cause of morbidity and mortality in AIDS patients. M. avium can be isolated as three major morphotypes: smooth-transparent (SmT ), smooth-opaque (SmO) and rough (Rg)...
  75. ncbi Selective killing of Mycobacterium avium-infected macrophages by inhibition of phosphorylated signal transducer and activator of transcription type 1
    Sabrina Dominici
    Institutes of Biochemistry G Fornaini, University of Urbino Carlo Bo, Urbino, Italy
    J Infect Dis 198:95-100. 2008
    b>Mycobacterium avium infects mononuclear phagocytes, which thereby become reservoirs for this pathogen. Currently recommended therapy does not ensure the eradication of intracellular bacteria. Here, we report that M...
  76. ncbi The cytolytic activity of natural killer cells is not involved in the restriction of Mycobacterium avium growth
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Int Immunol 15:895-901. 2003
    Severe combined immunodeficiency (SCID) mice were used to analyze the role of NK cells in resistance to Mycobacterium avium. The neutralization of IFN-gamma in these animals led to an exacerbation of the infection associated with a ..
  77. ncbi Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Antimicrob Chemother 60:1064-73. 2007
    ..Improvement of the efficacy of drug treatment in mycobacterial infection by the development and application of targeted drug delivery...
  78. doi Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
    Shigeru Ariki
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Immunol 187:2586-94. 2011
    ..b>Mycobacterium avium is one of the well-known opportunistic pathogens that can replicate within macrophages...
  79. ncbi Mechanisms of Mycobacterium avium pathogenesis
    L E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco 94115, USA
    Arch Immunol Ther Exp (Warsz) 48:521-7. 2000
    Infections caused by Mycobacterium avium are common in AIDS patients and patients with chronic lung diseases. The bacterium can be acquired both through the intestinal route and respiratory route. M...
  80. ncbi Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Portugal
    J Leukoc Biol 76:1039-46. 2004
    ..ligand (OX40L), and CD137 ligand (4-1BBL) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57Bl/6 mice. Only the blocking of CD153 led to increased mycobacterial burdens...
  81. pmc Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection
    Horacio Bach
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St, Vancouver, V5Z 3J5 British Columbia, Canada
    Infect Immun 74:6540-6. 2006
    ..The genome sequence of Mycobacterium avium subsp. paratuberculosis, the causative agent of Johne's disease, does not possess a defined tyrosine kinase...
  82. doi Epidemiological investigation of a Mycobacterium avium subsp. hominissuis outbreak in swine
    J Alvarez
    VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain
    Epidemiol Infect 139:143-8. 2011
    b>Mycobacterium avium subsp. hominissuis (MAH) infection in swine may cause granulomatous lesions in lymph nodes that must undergo differential diagnosis with those caused by M. tuberculosis complex members...
  83. ncbi Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage activation and apoptosis induction by picolinic acid plus IFNgamma
    Teresa F Pais
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Microbiology 150:1507-18. 2004
    ..of mouse macrophages with picolinic acid (PA) and gamma-interferon (IFNgamma) led to the restriction of Mycobacterium avium proliferation concomitant with the sequential acquisition of metabolic changes typical of apoptosis, ..
  84. pmc The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture
    Robert J Greenstein
    Department of Surgery, James J Peters VA Medical Center, Bronx, New York, United States of America
    PLoS ONE 5:e11099. 2010
    ..are increasingly compelling data that another "autoimmune" affliction, Crohn disease, may be caused by Mycobacterium avium subspecies paratuberculosis (MAP). Like M. tb, MAP is systemic...
  85. doi Mitogen-activated protein kinases p38 and ERK1/2 regulated control of Mycobacterium avium replication in primary murine macrophages is independent of tumor necrosis factor-α and interleukin-10
    Kirsten Klug
    Division of Microbial Interface Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Innate Immun 17:470-85. 2011
    ..function on mycobacterial replication from indirect, cytokine-mediated effects, we studied the growth of Mycobacterium avium strains in wild-type and tumor necrosis factor (TNF)-α- or interleukin (IL)-10-deficient bone marrow-..
  86. ncbi Naturally occurring horizontal gene transfer and homologous recombination in Mycobacterium
    Elzbieta Krzywinska
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
    Microbiology 150:1707-12. 2004
    ..Here, direct evidence of HGT between strains of Mycobacterium avium representing two different serotypes is presented...
  87. ncbi Acetohydroxyacid synthase from Mycobacterium avium and its inhibition by sulfonylureas and imidazolinones
    Yehudit Zohar
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochim Biophys Acta 1649:97-105. 2003
    ..by infection with Mycobacterium tuberculosis or sometimes, particularly in immune-compromised patients, Mycobacterium avium. The aim of this study was to create a tool that could be used in the search for new anti-TB drugs that ..
  88. pmc Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Infect Immun 73:3577-86. 2005
    Infection by virulent Mycobacterium avium caused progressive severe lymphopenia in C57BL/6 mice due to increased apoptosis rates...
  89. ncbi Establishment of Mycobacterium avium subsp. paratuberculosis infection in the intestine of ruminants
    Olöf G Sigurethardóttir
    Department of Pathology, National Veterinary Institute, The Norwegian School of Veterinary Science, P O Box 8156 Dep, 0033 Oslo, Norway
    Adv Drug Deliv Rev 56:819-34. 2004
    b>Mycobacterium avium subsp. paratuberculosis (M. a. paratuberculosis) is the cause of paratuberculosis, which is a chronic enteritis of ruminants characterized by granulomatous inflammation...
  90. ncbi Lack of evidence for Mycobacterium avium subspecies paratuberculosis in Crohn's disease
    Hugh Freeman
    Inflamm Bowel Dis 11:782-3. 2005
  91. pmc Opsonization effects on Mycobacterium avium subsp. paratuberculosis--macrophage interactions
    J Hostetter
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Clin Diagn Lab Immunol 12:793-6. 2005
    High antibody titers in ruminants infected with Mycobacterium avium subsp. paratuberculosis correlates with disease progression. Effects of humoral responses during mycobacterial infection are not completely understood...
  92. ncbi The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:73-9. 2005
    ..To investigate in guinea pigs the effects of presensitization with well characterized Mycobacterium avium strains on the vaccine efficacy of BCG and of two recently developed, avirulent strains of Mycobacterium ..
  93. pmc Fluorescence in situ hybridization using peptide nucleic acid probes for rapid detection of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis in potable-water biofilms
    Markku J Lehtola
    Environmental Healthcare Unit, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Appl Environ Microbiol 72:848-53. 2006
    ..for the first time a high-affinity peptide nucleic acid (PNA) oligonucleotide sequence for detecting Mycobacterium avium bacteria, including the opportunistically pathogenic subspecies M. avium subsp. avium, M. avium subsp...
  94. pmc Comparison of methods for processing drinking water samples for the isolation of Mycobacterium avium and Mycobacterium intracellulare
    Rachel Thomson
    Department of Thoracic Medicine, The Prince Charles Hospital, Rode Rd, Chermside 4032, Australia
    Appl Environ Microbiol 74:3094-8. 2008
    ..This study compared methods of processing potable water samples for the isolation of Mycobacterium avium and Mycobacterium intracellulare using spiked sterilized water and tap water decontaminated using 0...
  95. ncbi Effect of different cell fractions of Mycobacterium avium and vaccination regimens on Mycobacterium avium infection
    J O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Scand J Immunol 59:478-84. 2004
    ..The imposition and the timing of stress significantly influenced the outcome of Mycobacterium avium infection in chickens...
  96. pmc Evidence of the presence of IS1245 and IS1311 or closely related insertion elements in nontuberculous mycobacteria outside of the Mycobacterium avium complex
    Andreas P Keller
    Department of General Pediatrics, Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Microbiol 40:1869-72. 2002
    ..Specific PCR products were observed in Mycobacterium malmoense, Mycobacterium scrofulaceum, and Mycobacterium nonchromogenicum, indicating that IS1245 and IS1311 are not limited to the Mycobacterium avium complex.
  97. doi Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium
    Sofia Sousa Fernandes
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    Microbes Infect 12:287-94. 2010
    ..an array of iron chelating ligands of the 3-hydroxy-4-pyridinone family, in the intramacrophagic growth of Mycobacterium avium. We found that bidentate chelators, namely N-alkyl-3-hydroxy-4-pyridinones and N-aryl-3-hydroxy-4-..
  98. pmc Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophages
    W Zhong
    Department of Microbiology, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 69:6618-24. 2001
    ..protein 1 (Nramp1) confers resistance to the growth of a variety of intracellular pathogens including Mycobacterium avium. Recently several other proteins that are involved in iron transport, including the highly homologous iron ..
  99. pmc Multiplex PCR provides a low-cost alternative to DNA probe methods for rapid identification of Mycobacterium avium and Mycobacterium intracellulare
    D Cousins
    Australian Reference Laboratory for Bovine Tuberculosis, Agriculture Western Australia, South Perth, Australia
    J Clin Microbiol 34:2331-3. 1996
    ..by the multiplex method. These results confirm that the multiplex PCR, which is simple to perform and cheaper than commercial probe methods, is suitable for routine identification of M. avium and M. intracellulare...
  100. ncbi Characterization and expression of secA in Mycobacterium avium
    A Limia
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, 2200 Webster Street, Suite 305, San Francisco, CA 94115, USA
    FEMS Microbiol Lett 197:151-7. 2001
    b>Mycobacterium avium is both a pathogen that infects several hosts such as humans, pigs, and birds, as well as a microorganism that is encountered in environmental sources (soil and water)...
  101. pmc Comparison of variable-number tandem-repeat markers typing and IS1245 restriction fragment length polymorphism fingerprinting of Mycobacterium avium subsp. hominissuis from human and porcine origins
    Taneli Tirkkonen
    Faculty of Veterinary Medicine, Department of Production Animal Medicine, University of Helsinki, Finland
    Acta Vet Scand 52:21. 2010
    ..The objective of this study was to compare the IS1245 RFLP pattern and MIRU-VNTR typing to study the genetic relatedness of M. avium strains isolated from slaughter pigs and humans in Finland with regard to public health aspects...

Research Grants69

  1. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..A specific antigenic stimuli has not been identified, but pathogenic bacteria such as Mycobacterium avium subsp paratuberculosis (MAP) and specific invasive E. coli strains have been proposed...
  2. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2004
    ..A specific antigenic stimuli has not been identified, but pathogenic bacteria such as Mycobacterium avium subsp paratuberculosis (MAP) and specific invasive E. coli strains have been proposed...
  3. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2003
    ..A specific antigenic stimuli has not been identified, but pathogenic bacteria such as Mycobacterium avium subsp paratuberculosis (MAP) and specific invasive E. coli strains have been proposed...
  4. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2002
    ..A specific antigenic stimuli has not been identified, but pathogenic bacteria such as Mycobacterium avium subsp paratuberculosis (MAP) and specific invasive E. coli strains have been proposed...
  5. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2010
    ..In this proposal, I describe the use of a mouse model of chronic Mycobacterium avium infection to understand changes in HSC function triggered by the innate immune response...
  6. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 1999
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  7. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2002
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  8. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2000
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  9. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2001
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  10. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2003
    ..We are exploring the mechanisms that control cell migration, and adhesion; and the effects of different matrix proteins on these processes. ..
  11. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2000
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  12. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2002
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  13. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2002
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  14. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2001
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  15. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2001
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  16. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2003
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  17. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    ..evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV sonicate, PPD, ESAT-..
  18. Multiplex TB-M.avium complex Fluorescent in Situ hybridization Assay, direct from
    Jyotsna Shah; Fiscal Year: 2009
    ..in-situ hybridization assay that detects and differentiates Mycobacterium tuberculosis complex (MTB) and Mycobacterium avium complex (MAC) in culture and sputum...
  19. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2002
    ..project is the discovery of new drugs against Pneumocystis carinii (Pc), Toxoplasma gondii (Tg), Mycobacterium avium (My), and Cryptosporidium parvum (Cp), four opportunistic pathogens known to cause morbidity and mortality ..
  20. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2003
    ..project is the discovery of new drugs against Pneumocystis carinii (Pc), Toxoplasma gondii (Tg), Mycobacterium avium (My), and Cryptosporidium parvum (Cp), four opportunistic pathogens known to cause morbidity and mortality ..
  21. M. AVIUM DISEASE--INHALED LIPOSOME ANTI-TB DRUG THERAPY
    Hans Schreier; Fiscal Year: 1990
    M. AVIUM DISEASE: INHALED LIPOSOME ANTI-TB DRUG THERAPY. Of the atypical mycobacteria, the Mycobacterium avium-intracellular complex (MAIC) is the most common human pathogen...
  22. DICATIONIC DRUGS--TREATMENT FOR AIDS-RELATED INFECTIONS
    Richard Tidwell; Fiscal Year: 1999
    ..several other important AIDS related pathogens including: Cryptococcus neoformans, Cryptosporidium parvum, Mycobacterium avium, Toxoplasma gondii, Mycobacterium tuberculosis, and Candida albicans. Together with P...
  23. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MIETTINEN; Fiscal Year: 2009
    ..shown that one FPR haplotype is associated with a reduced capacity to detect and respond to a peptide from Mycobacterium avium ssp. paratuberculosis...
  24. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..shown that one FPR haplotype is associated with a reduced capacity to detect and respond to a peptide from Mycobacterium avium ssp. paratuberculosis...
  25. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2002
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  26. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2000
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  27. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 1999
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  28. MYCOBACTERIAL CELL WALL AND DRUG DISCOVERY
    Patrick Brennan; Fiscal Year: 2007
    ..of the pyruvic[unreadable] acid-containing "C-mycoside" glycopeptidolipid (GPL) antigens of the[unreadable] Mycobacterium avium/Mycobacterium intracellulare/Mycobacterium scrofulaceum[unreadable] complex will continue in concert with a ..
  29. SURFACE ANTIGENS OF M LEPRAE AND OTHER MYCOBACTERIA
    Patrick Brennan; Fiscal Year: 1993
    ..Analysis of the pyruvic acid-containing "C-mycoside" glycopeptidolipid (GPL) antigens of the Mycobacterium avium/Mycobacterium intracellulare/Mycobacterium scrofulaceum complex will continue in concert with a probing of ..
  30. Target for Mefloquine in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2001
    ..Mycobacterium tuberculosis and Mycobacterium avium are intracellular pathogens that infect both healthy individuals and immunocompromised patients. M...
  31. Target for Mefloquine in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2002
    ..Mycobacterium tuberculosis and Mycobacterium avium are intracellular pathogens that infect both healthy individuals and immunocompromised patients. M...
  32. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2004
    ..of Chronic Diseases: Novel Approaches to Pathogen Detection" and specifically addresses the study of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis). M...
  33. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2003
    ..of Chronic Diseases: Novel Approaches to Pathogen Detection" and specifically addresses the study of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis). M...
  34. M AVIUM IMMUNE RESPONSES--IMPLICATIONS FOR THERAPY
    W Boom; Fiscal Year: 1999
    Disseminated Mycobacterium avium complex (MAC) infection is the most common bacterial opportunistic complication in patients with AIDS...
  35. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2002
    ..of Chronic Diseases: Novel Approaches to Pathogen Detection" and specifically addresses the study of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis). M...
  36. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2005
    ..of Chronic Diseases: Novel Approaches to Pathogen Detection" and specifically addresses the study of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis). M...
  37. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2001
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  38. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2003
    ..Three common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  39. MOLECULAR BIOLOGY OF MYCOBACTERIA & THEIR PHAGES
    Graham Hatfull; Fiscal Year: 1990
    ..AIDS patients are also susceptible to opportunistic infection by Mycobacterium avium, which responds poorly to antibiotics and contributes to a significant proportions of deaths among AIDS ..
  40. RESISTANCE OF OPPORTUNISTIC INFECTION BY MYCOBACTERIA
    D Blanchard; Fiscal Year: 1990
    b>Mycobacterium avium-intracellulare (MAI) is an atypical mycobacterium commonly found in the environment which rarely causes invasive disease in humans in the absence of a pre-existing condition...
  41. PATHOGENESIS OF OPPORTUNISTIC INFECTION DUE TO MAC
    Antonino Catanzaro; Fiscal Year: 1992
    b>Mycobacterium avium-intracellulare complex (MAC) causes severe disseminated disease in AIDS patients. The macrophage is the cell responsible for killing MAC and initiating the host immune response...
  42. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg) and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly ..
  43. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg) and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly ..
  44. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg)and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly those with AIDS...
  45. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2009
    Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg)and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly those with AIDS...
  46. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2009
    Pathogens such as Pneumocystis (P), Toxoplasma gondii (Tg)and Mycobacterium avium (Ma) are major causes of opportunistic infection and mortality in immunocompromised patients, particularly those with AIDS...
  47. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2005
    ..Many occur in bacteria pathogenic to man (e.g. Mycobacterium tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, ..
  48. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2004
    ..Many occur in bacteria pathogenic to man (e.g. Mycobacterium tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, ..
  49. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2006
    ..Many occur in bacteria pathogenic to man (e.g. Mycobacterium tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, ..
  50. TrHbs: Biophysical Consequences of a Nonpolar Tunnel
    Joel Friedman; Fiscal Year: 2007
    ..Many occur in bacteria pathogenic to man (e.g. Mycobacterium tuberculosis (TB), Mycobacterium avium, Mycobacterium leprae, Cornybacterium diphtheriae, Bordetella pertussis, Legionella pneumophila, ..
  51. RECOMBINANT IL-2 IN HIV INFECTED CHILDREN
    Kenneth McIntosh; Fiscal Year: 2001
    ..associated with a higher risk of infection with opportunistic organisms, suh as Pneumocystis carinii and Mycobacterium avium complex. Restoration of immune function in HIV-infected children is a highly desirable goal...
  52. RECOMBINANT IL-2 IN HIV INFECTED CHILDREN
    Kenneth McIntosh; Fiscal Year: 2000
    ..associated with a higher risk of infection with opportunistic organisms, suh as Pneumocystis carinii and Mycobacterium avium complex. Restoration of immune function in HIV-infected children is a highly desirable goal...
  53. SQ641, new drug candidate to treat NTM infections
    VENKATA REDDY; Fiscal Year: 2009
    b>Mycobacterium avium complex (MAC) and M. abscessus (MAB) are the two most common nontuberculous mycobacteria (NTM) that cause human disease, and the incidence of NTM infections has been increasing worldwide...
  54. SQ641, new drug candidate to treat NTM infections
    Venkata M Reddy; Fiscal Year: 2010
    b>Mycobacterium avium complex (MAC) and M. abscessus (MAB) are the two most common nontuberculous mycobacteria (NTM) that cause human disease, and the incidence of NTM infections has been increasing worldwide...
  55. TARGETED THERAPY OF MYCOBACTERIUM AVIUM INFECTIONS
    PATTISAPU GANGADHARAM; Fiscal Year: 1993
    b>Mycobacterium avium-intracellulare complex (MAC) causes serious disseminated bacterial infection in patients with the acquired immunodeficiency syndrome (AIDS)...
  56. Opportunistic infections in intestinal dysfunction & wasting
    Saul Tzipori; Fiscal Year: 2002
    ..We will specifically target the role of Cryptosporidium parvum, Enterocytozoon bieneusi, and Mycobacterium avium complex (MAC), and determine their contribution, if any, to gut dysfunction...
  57. Opportunistic infections in intestinal dysfunction & wasting
    Saul Tzipori; Fiscal Year: 2000
    ..We will specifically target the role of Cryptosporidium parvum, Enterocytozoon bieneusi, and Mycobacterium avium complex (MAC), and determine their contribution, if any, to gut dysfunction...