mycobacterium marinum

Summary

Summary: A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)

Top Publications

  1. ncbi Multicenter study of incidence of Mycobacterium marinum in humans in Spain
    M Casal
    Mycobacteria Reference Center, Faculty of Medicine, Cordoba University, Spain
    Int J Tuberc Lung Dis 5:197-9. 2001
  2. ncbi Mycobacterial infection in farmed turbot Scophthalmus maximus
    N M S dos Santos
    Institute for Molecular and Cell Biology, Rua do Campo Alegre No 823, 4150 180 Porto, Portugal
    Dis Aquat Organ 52:87-91. 2002
  3. ncbi Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 2:29-39. 2007
  4. ncbi Photo quiz. Case 5. The patient had a large tropical fish tank. The lesion was a fish tank granuloma caused by Mycobacterium marinum
    Nigel Stollery
    Leicester Royal Infirmary
    Practitioner 251:32, 34. 2007
  5. ncbi The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
  6. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
  7. ncbi PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 73:329-40. 2009
  8. ncbi Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole
    Jennifer Smith
    Department of Cell Biology and Molecular Genetics and Maryland Pathogens Research Institute, University of Maryland, College Park, Maryland 20742, USA
    Infect Immun 76:5478-87. 2008
  9. ncbi Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
  10. ncbi Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation
    Abdallah M Abdallah
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    J Immunol 187:4744-53. 2011

Research Grants

  1. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2005
  2. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
  3. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2006
  4. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2010
  5. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2006
  6. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2007
  7. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2009
  8. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2010
  9. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2003
  10. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2006

Detail Information

Publications193 found, 100 shown here

  1. ncbi Multicenter study of incidence of Mycobacterium marinum in humans in Spain
    M Casal
    Mycobacteria Reference Center, Faculty of Medicine, Cordoba University, Spain
    Int J Tuberc Lung Dis 5:197-9. 2001
    A retrospective survey was carried out on the epidemiological monitoring of the isolation incidence of Mycobacterium marinum in 21 laboratories, in an attempt to gain an insight into the frequency of its isolation in Spain...
  2. ncbi Mycobacterial infection in farmed turbot Scophthalmus maximus
    N M S dos Santos
    Institute for Molecular and Cell Biology, Rua do Campo Alegre No 823, 4150 180 Porto, Portugal
    Dis Aquat Organ 52:87-91. 2002
    ..Bacteriological analysis of organs with granulomas led to the isolation of Mycobacterium marinum. Further analysis, to determine the prevalence of the infection in the farm and to identify its source, ..
  3. ncbi Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 2:29-39. 2007
    ..Using the optically transparent and genetically tractable zebrafish embryo-Mycobacterium marinum model of tuberculosis, we have directly examined early infection in the presence and absence of ..
  4. ncbi Photo quiz. Case 5. The patient had a large tropical fish tank. The lesion was a fish tank granuloma caused by Mycobacterium marinum
    Nigel Stollery
    Leicester Royal Infirmary
    Practitioner 251:32, 34. 2007
  5. ncbi The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
    ..However, work in zebrafish infected with Mycobacterium marinum suggests that granulomas contribute to early bacterial growth...
  6. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
    ..Adult zebrafish are naturally susceptible to tuberculosis caused by Mycobacterium marinum. Here, we exploit the optical transparency of zebrafish embryos to image the events of M...
  7. ncbi PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 73:329-40. 2009
    ..Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants showed that a number of ..
  8. ncbi Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole
    Jennifer Smith
    Department of Cell Biology and Molecular Genetics and Maryland Pathogens Research Institute, University of Maryland, College Park, Maryland 20742, USA
    Infect Immun 76:5478-87. 2008
    ..marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection...
  9. ncbi Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
    ..We monitored transparent Mycobacterium marinum-infected zebrafish live to conduct a stepwise dissection of how TNF signaling operates in mycobacterial ..
  10. ncbi Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation
    Abdallah M Abdallah
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    J Immunol 187:4744-53. 2011
    ..proteins secreted by ESX-5 are not required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells. However, the M...
  11. ncbi Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
    David M Tobin
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Cell Microbiol 10:1027-39. 2008
    ..b>Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms...
  12. ncbi The secret lives of the pathogenic mycobacteria
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 57:641-76. 2003
    ..In addition, we highlight current controversies and unanswered questions in these areas...
  13. ncbi A mycobacterium ESX-1-secreted virulence factor with unique requirements for export
    Bryant McLaughlin
    Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e105. 2007
    ..Both the Mycobacterium marinum and the Mycobacterium tuberculosis genomes contain an extended region of difference 1 (extRD1) locus that ..
  14. ncbi Identification of Mycobacterium marinum macrophage infection mutants
    Parmod K Mehta
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center, 471 Reynolds Medical Building, College Station, TX 77843, USA
    Microb Pathog 40:139-51. 2006
    b>Mycobacterium marinum is an important pathogen of humans, amphibians and fish. Most pathogenic mycobacteria, including M. marinum, infect, survive and replicate primarily intracellularly within macrophages...
  15. ncbi Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins
    Musa Sani
    Division of Cell Biology B6, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital NKI AVL, Amsterdam, The Netherlands
    PLoS Pathog 6:e1000794. 2010
    ..Further immunogenic and proteomic analyses revealed that Mycobacterium marinum capsule contains high amounts of proteins that are secreted via the ESX-1 pathway...
  16. ncbi A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion
    Lian-Yong Gao
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Mol Microbiol 53:1677-93. 2004
    ..A screen of Mycobacterium marinum transposon mutant library led to isolation of eight mutants that failed to cause haemolysis, all of which ..
  17. ncbi ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection
    Ingrid C Koo
    Program in Microbial Pathogenesis and Host Defense, University of California, San Fancisco, CA, USA
    Cell Microbiol 10:1866-78. 2008
    ..a virulence factor necessary for phagosome escape and host cell lysis by a contact-dependent haemolysin in Mycobacterium marinum. Here we show that ESX-1 from M. marinum and M...
  18. ncbi The complex relationship between mycobacteria and macrophages: it's not all bliss
    Sarah M Fortune
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 2:5-6. 2007
    ..show in a recent issue of Cell, there are both benefits and drawbacks for the pathogen in adopting this strategy, and some of our fundamental assumptions about how the host cell and bacterium interact might need to be reexamined...
  19. ncbi Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components
    Astrid M van der Sar
    Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 46:2317-32. 2009
    ..outcomes: an acute disease with early lethality or a chronic disease with granuloma formation, caused by Mycobacterium marinum strains Mma20 and E11, respectively...
  20. ncbi Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin
    Jonathan M Solomon
    Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 71:3578-86. 2003
    b>Mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial ..
  21. ncbi Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA
    Science 327:466-9. 2010
    ..However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages ..
  22. ncbi Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas
    D M Bouley
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Infect Immun 69:7820-31. 2001
    b>Mycobacterium marinum causes long-term subclinical granulomatous infection in immunocompetent leopard frogs (Rana pipiens)...
  23. ncbi Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Comp Immunol 32:36-49. 2008
    ..Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation.
  24. ncbi Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis
    Michael G Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    FEMS Microbiol Lett 225:177-82. 2003
    We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish (Danio rerio) for the study of mycobacterial disease...
  25. ncbi Role of the WASP family proteins for Mycobacterium marinum actin tail formation
    Luisa M Stamm
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:14837-42. 2005
    b>Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread...
  26. ncbi Experimental exposure of zebrafish, Danio rerio (Hamilton), to Mycobacterium marinum and Mycobacterium peregrinum reveals the gastrointestinal tract as the primary route of infection: a potential model for environmental mycobacterial infection
    M J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Fish Dis 30:587-600. 2007
    ..Danio rerio (Hamilton) were exposed by bath immersion and intubation to Mycobacterium marinum and Mycobacterium peregrinum isolates obtained from diseased zebrafish...
  27. ncbi Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
    Timothy P Stinear
    Department of Microbiology, Monash University, Clayton 3800, Australia
    Genome Res 18:729-41. 2008
    b>Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M...
  28. ncbi Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR_2343) protein
    Yoann Rombouts
    Universite de Lille 1, Unite de Glycobiologie Structurale et Fonctionnelle, F 59650 Villeneuve d Ascq, France
    J Biol Chem 286:33678-88. 2011
    ..the fine structure of the glycan backbone of lipooligosaccharides (LOS-I to LOS-IV) isolated from Mycobacterium marinum, a close relative of Mycobacterium tuberculosis...
  29. ncbi Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab
    J C Fallon
    Department of Dermatology, Beaumont Hospital, Dublin, Ireland
    Clin Exp Dermatol 33:43-5. 2008
    ..We report sporotrichoid spread of Mycobacterium marinum in a 37-year-old woman with Crohn's disease, who had been receiving infliximab infusions for 2 years...
  30. ncbi The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species
    Selvakumar Subbian
    Dept, Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center College of Medicine, College Station, TX 77843 1114, USA
    BMC Microbiol 7:4. 2007
    ..We recently identified a locus in Mycobacterium marinum, mel2, that plays a role during infection of macrophages...
  31. ncbi Mycobacterium marinum infections of the distal upper extremities: clinical course and imaging findings in two cases with delayed diagnosis
    Kimberly K Amrami
    Department of Radiology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Skeletal Radiol 32:546-9. 2003
    b>Mycobacterium marinum infections cause tenosynovitis of the distal upper extremities and develop as a consequence of skin abrasions acquired in contaminated water...
  32. ncbi Transposition of Tn5367 in Mycobacterium marinum, using a conditionally recombinant mycobacteriophage
    Jan Rybniker
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    J Bacteriol 185:1745-8. 2003
    b>Mycobacterium marinum is a close relative of the obligate human pathogen Mycobacterium tuberculosis. As with M. tuberculosis, M. marinum causes intracellular infection of poikilothermic vertebrates and skin infection in humans...
  33. ncbi Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan
    Nicole N Driessen
    Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Microbiology 156:3492-502. 2010
    ..Here, we report that a third gene is involved, MMAR_2380, which is the Mycobacterium marinum orthologue of Rv1565c. MMAR_2380 encodes a predicted transmembrane acyltransferase. In M...
  34. ncbi A prolonged case of Mycobacterium marinum flexor tenosynovitis: radiographic and histological correlation, and review of the literature
    M D Wongworawat
    USC University Hospital, 1500 San Pablo Street, Los Angeles, CA 90033, USA
    Skeletal Radiol 32:542-5. 2003
    We report on a 30-year-old man with prolonged Mycobacterium marinum flexor tenosynovitis. Due to low clinical suspicion, diagnosis was not made until 8 years after initial presentation...
  35. ncbi The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    J Immunol 181:7166-75. 2008
    ..To better understand the role of ESX-5 effector proteins in virulence, we analyzed the interactions of Mycobacterium marinum ESX-5 mutant with human macrophages (Mphi)...
  36. ncbi MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish
    Jia Yu
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Medical Microbiology, Fudan University, 138 Yi Xue Yuan Road, Shanghai, China
    Microbes Infect 13:33-41. 2011
    ..In this study, we isolated a mutant of Mycobacterium marinum in which MMAR_2770, a previously uncharacterized gene encoding a predicted short-chain dehydrogenase/..
  37. ncbi Disseminated Mycobacterium marinum infection with extensive cutaneous eruption and bacteremia in an immunocompromised patient
    Markus Streit
    Department of Dermatology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Eur J Dermatol 16:79-83. 2006
    b>Mycobacterium marinum can cause fish tank granuloma (or swimming pool or aquarium granuloma) in immunocompetent patients...
  38. ncbi Polar localization of virulence-related Esx-1 secretion in mycobacteria
    Fredric Carlsson
    Department of Microbial Pathogenesis, Genentech Inc, South San Francisco, California, United States of America
    PLoS Pathog 5:e1000285. 2009
    The Esx-1 (type VII) secretion system is critical for virulence of both Mycobacterium tuberculosis and Mycobacterium marinum, and is highly conserved between the two species...
  39. ncbi Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence
    Astrid M van der Sar
    Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Infect Immun 72:6306-12. 2004
    b>Mycobacterium marinum causes a systemic tuberculosis-like disease in a large number of poikilothermic animals and is used as a model for mycobacterial pathogenesis...
  40. ncbi Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection
    Monica Hagedorn
    Department de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Cell Microbiol 9:2716-33. 2007
    b>Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, provides a useful model to study the pathogenesis of tuberculosis in genetically tractable model organisms...
  41. ncbi Superinfecting mycobacteria home to established tuberculous granulomas
    Christine L Cosma
    Department of Microbiology, University of Washington School of Medicine, Box 357242, Seattle, Washington 98195, USA
    Nat Immunol 5:828-35. 2004
    ..We show here that superinfecting Mycobacterium marinum traffic rapidly into preexisting granulomas, including their caseous (necrotic) centers, through specific ..
  42. ncbi Identification of Mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis
    Kristin M Ruley
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 232:75-81. 2004
    b>Mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related Mycobacterium species (outside the M. tuberculosis complex) to M. tuberculosis, the etiologic agent of human tuberculosis...
  43. ncbi Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
    Timothy P Stinear
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75725 Paris Cedex 15, France
    Genome Res 17:192-200. 2007
    ..Comparisons with the recently completed 6.6-Mb genome of Mycobacterium marinum revealed >98% nucleotide sequence identity and genome-wide synteny. However, as well as the plasmid, M...
  44. ncbi Mycobacterium marinum infections of the upper extremity
    Christopher L Hess
    Division of Plastic Surgery, Medstar Georgetown University Hospital, Washington, DC 20007, USA
    Plast Reconstr Surg 115:55e-59e. 2005
    A significant number of patients infected with Mycobacterium marinum have been treated at the Curtis National Hand Center in Baltimore, Maryland. The purpose of this study was to review the authors' experience with M...
  45. ncbi Genotyping Mycobacterium ulcerans and Mycobacterium marinum by using mycobacterial interspersed repetitive units
    Pieter Stragier
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium
    J Bacteriol 187:1639-47. 2005
    ..MIRU typing has significant potential value for discriminating between reoccurrence and reinfection for M. ulcerans disease...
  46. ncbi Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium
    Luisa M Stamm
    Program in Host-Pathogen Interactions, 600 16th Street, Genentech Hall N212, University of California, San Francisco, CA 94158, USA
    Microbes Infect 6:1418-28. 2004
    b>Mycobacterium marinum is being used increasingly as a model for understanding pathogenic mycobacteria. However, recently discovered differences between M. marinum and M...
  47. ncbi A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species
    Selvakumar Subbian
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center, 471 Reynolds Medical Building, College Station, TX 77843, USA
    Infect Immun 75:127-34. 2007
    ..We recently constructed a Mycobacterium marinum mel2 locus mutant, which is known to affect macrophage infection...
  48. ncbi Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Mol Immunol 42:1185-203. 2005
    The Mycobacterium marinum-zebrafish infection model was used in this study for analysis of a host transcriptome response to mycobacterium infection at the organismal level...
  49. ncbi Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum
    Huiping Ren
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Microbiol 63:1345-59. 2007
    ..This is an important step in assessing the differential distribution of LOSs among Mycobacterium species and understanding the role of LOSs in mycobacterial virulence...
  50. ncbi New models for the study of Mycobacterium-host interactions
    Tamara C Pozos
    Department of Microbiology, Box 357242, 1959 Pacific Street, University of Washington Medical School, Seattle, Washington 98195, USA
    Curr Opin Immunol 16:499-505. 2004
    ....
  51. ncbi Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila
    Marc S Dionne
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA
    Curr Biol 16:1977-85. 2006
    ..Here, we examine the pathogenesis associated with Mycobacterium marinum infection in the fly. M. marinum is closely related to M...
  52. ncbi LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum
    Adeline Burguière
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT
    J Biol Chem 280:42124-33. 2005
    ..Previous studies have shown that Mycobacterium marinum produces large amounts of a diacylglycosylphenolphthiocerol, "phenolic" glycolipid...
  53. ncbi Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor
    Marcus J Yip
    Department of Microbiology, Monash University, Wellington Road, Clayton 3800, Australia
    J Bacteriol 189:2021-9. 2007
    ..ulcerans and Mycobacterium marinum. Here, we show by multiple genetic methods, including multilocus sequence analysis and DNA-DNA ..
  54. ncbi Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility
    Luisa M Stamm
    Program in Host-Pathogen Interactions, University of California San Francisco, San Francisco, CA 94158, USA
    J Exp Med 198:1361-8. 2003
    ..Here we show that Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of actively ..
  55. ncbi A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages
    Lian-Yong Gao
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, 600 16th St, Campus Box 2140, San Francisco, CA 94143-2140, USA
    Infect Immun 74:1757-67. 2006
    ..We have found a Mycobacterium marinum locus of two genes that is required for both invasion and intracellular survival in macrophages...
  56. ncbi Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones
    Martin Bråbäck
    Department of Medical Microbiology, Lund University, University Hospital, S 205 02 Malmo, Sweden
    Antimicrob Agents Chemother 46:1114-6. 2002
    The susceptibility pattern of Mycobacterium marinum was determined. Quinupristin-dalfopristin and telithromycin were less active than clarithromycin. Linezolid showed good antimicrobial activity at clinically achievable concentrations...
  57. ncbi Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection
    Kaman Chan
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:3920-5. 2002
    ..We analyzed the gene expression profile of Mycobacterium marinum, the cause of fish and amphibian tuberculosis, during its persistence in granulomas...
  58. ncbi The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation
    Tracy Tan
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada
    Cell Microbiol 8:1417-29. 2006
    ..In this study, we isolated a mutant of Mycobacterium marinum defective in the secretion of ESAT-6 and CFP-10...
  59. ncbi Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence
    T P Stinear
    Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Bacteriol 182:6322-30. 2000
    Previous studies of the 16S rRNA genes from Mycobacterium ulcerans and Mycobacterium marinum have suggested a very close genetic relationship between these species (99.6% identity)...
  60. ncbi Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family
    L Ramakrishnan
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 288:1436-9. 2000
    ..We identified several genes preferentially expressed when Mycobacterium marinum, the cause of fish and amphibian tuberculosis, resides in host granulomas and/or macrophages...
  61. ncbi Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum
    Jessica L Porter
    Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia
    Microbiology 155:1923-33. 2009
    ..of these two constructs permitted the two-step transfer of the entire 174 kb pMUM001 plasmid to Mycobacterium marinum, a rapidly growing non-mycolactone-producing mycobacterium that is a close genetic relative of M. ulcerans...
  62. ncbi Interleukin-8 is differentially expressed by human-derived monocytic cell line U937 infected with Mycobacterium tuberculosis H37Rv and Mycobacterium marinum
    Chang Hwa Song
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Mun hwa dong, Jung ku, Daejeon 301 747, Republic of Korea
    Infect Immun 71:5480-7. 2003
    Although Mycobacterium marinum is closely related to Mycobacterium tuberculosis H37Rv genomically, the clinical outcome in humans is quite different for M. marinum and M. tuberculosis infections...
  63. ncbi The Mycobacterium marinum G13 promoter is a strong sigma 70-like promoter that is expressed in Escherichia coli and mycobacteria species
    L P Barker
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Microscopy Branch, Hamilton, MT 59840, USA
    FEMS Microbiol Lett 175:79-85. 1999
    A Mycobacterium marinum promoter, designated G13, was isolated from a promoter-trap library as a constitutive producer of the mutant green fluorescent protein...
  64. ncbi Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis
    T Tønjum
    Section of Molecular Microbiology, Institute of Microbiology, University of Oslo, National Hospital, Norway
    J Clin Microbiol 36:918-25. 1998
    ..tuberculosis. M. marinum may be particularly useful in this regard since strains of this species grow much more rapidly than M. tuberculosis and yet can cause systemic disease in immunocompromised hosts...
  65. ncbi Mycobacterial phenolic glycolipid inhibits phagosome maturation and subverts the pro-inflammatory cytokine response
    Nirmal Robinson
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    Traffic 9:1936-47. 2008
    ..We in this study characterize a glycolipid of Mycobacterium marinum identified through a screen of mutants disabled in inhibiting phagosome maturation to be phenolphthiocerol ..
  66. ncbi Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulcerans
    K Chemlal
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    J Clin Microbiol 40:2370-80. 2002
    ..a previous study with a set of temporally and geographically diverse Mycobacterium ulcerans (n = 29) and Mycobacterium marinum (n = 29) isolates (K. Chemlal, G. Huys, P.-A. Fonteyne, V. Vincent, A. G. Lopez, L. Rigouts, J. Swings, W...
  67. ncbi Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates
    Alexandra Aubry
    , , Paris, France
    Arch Intern Med 162:1746-52. 2002
    BACKGROUND: Mycobacterium marinum is a nontuberculous mycobacterium responsible for skin infections...
  68. ncbi In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures
    Michael L Kent
    Department of Microbiology, Center for Fish Disease Research, Oregon State University, Corvallis, OR 97331 3804, USA
    FEMS Microbiol Lett 257:69-75. 2006
    b>Mycobacterium marinum can cause systemic infection in fishes and skin infection in humans. Most strains grow better at <37 degrees C, which can explain the rarity of infections in humans...
  69. ncbi Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity
    Laura E Swaim
    Department of Microbiology, Box 357242, University of Washington, Seattle, WA 98195, USA
    Infect Immun 74:6108-17. 2006
    The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to tuberculosis caused by Mycobacterium marinum, a close genetic relative of the causative agent of human tuberculosis, Mycobacterium tuberculosis...
  70. ncbi Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Infect Immun 74:3125-33. 2006
    ..understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. tuberculosis. erp-deficient M...
  71. ncbi The identification of Mycobacterium marinum genes differentially expressed in macrophage phagosomes using promoter fusions to green fluorescent protein
    L P Barker
    Microscopy Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Mol Microbiol 29:1167-77. 1998
    b>Mycobacterium marinum, like Mycobacterium tuberculosis, is a slow-growing pathogenic mycobacteria that is able to survive and replicate in macrophages...
  72. ncbi Mycobacterium marinum: ubiquitous agent of waterborne granulomatous skin infections
    B Petrini
    Department of Clinical Microbiology, Karolinska University Hospital Solna and Karolinska Institutet, 17176, Stockholm, Sweden
    Eur J Clin Microbiol Infect Dis 25:609-13. 2006
    b>Mycobacterium marinum is a waterborne mycobacterium that commonly infects fish and amphibians worldwide...
  73. ncbi Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 186:1797-807. 2002
    ..ELISA and ELISPOT yielded comparable results, as did whole antigen and peptides (P<.0001). These results may be relevant for the development of novel assays for diagnosis of tuberculosis...
  74. ncbi Biofilm formation and biocide susceptibility testing of Mycobacterium fortuitum and Mycobacterium marinum
    Elias Bardouniotis
    Department of Biological Sciences, University of Calgary, 2500 University Drive N.W, Calgary, Alberta T2N 1N4, Canada
    Curr Microbiol 46:28-32. 2003
    ..This study examines the biofilm growth of Mycobacterium fortuitum and Mycobacterium marinum, using the MBEC trade mark assay system, and compares the susceptibility of planktonic and biofilm cells ..
  75. ncbi Amputation of a Mycobacterium marinum-infected hindlimb in an African bullfrog (Pyxicephalus adspersus)
    R Pizzi
    Mere Road Veterinary Surgery, 24 Mere Road, Blackpool, Lancashire
    Vet Rec 156:747-8. 2005
  76. ncbi Sporotrichoid presentation of Mycobacterium marinum infection of the upper extremity. A case report
    Mirjam Belić
    Department of Dermatology and Venereology, Maribor General Hospital, Ljubljanska 5, SI 2000 Maribor, Slovenia
    Acta Dermatovenerol Alp Panonica Adriat 15:135-9. 2006
    b>Mycobacterium marinum is a human opportunistic pathogen that is known to inhabit swimming pools, home aquariums, and natural bodies of salt and fresh water...
  77. ncbi Mycobacterium marinum tenosynovitis: three case reports and review of the literature
    Hung-Chin Tsai
    Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    Jpn J Infect Dis 59:337-40. 2006
    b>Mycobacterium marinum is one of the nontuberculosis mycobacteria responsible for skin infections. There have been very few case series of M. marinum infections reported in the English literature. Herein, we describe three patients with M...
  78. ncbi Mycobacterium marinum as a cause of chronic granulomatous tenosynovitis in the hand
    Hee Nee Pang
    Department of Hand Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    J Infect 54:584-8. 2007
    b>Mycobacterium marinum is an uncommon cause of chronic granulomatous flexor tenosynovitis and leads to significant morbidity in the hand. This paper aims to review our treatment of this infection and its clinical outcomes.
  79. ncbi Mycobacterium marinum infection: a case report and review of the literature
    Ryan P Johnson
    Brooke Army Medical Center, San Antonio, Texas, USA
    Cutis 79:33-6. 2007
    b>Mycobacterium marinum is a nontuberculous mycobacteria that is often acquired via contact with contaminated salt or fresh water...
  80. ncbi Immune and histopathologic responses of DNA-vaccinated hybrid striped bass Morone saxatilis x M. chrysops after acute Mycobacterium marinum infection
    David J Pasnik
    Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM, Virginia-Polytechnic Institute and State University (VPI and SU, Duck Pond Drive, Blacksburg, Virginia 24061, USA
    Dis Aquat Organ 73:33-41. 2006
    ..immune and histopathologic responses of hybrid striped bass vaccinated with a DNA vaccine encoding the Mycobacterium marinum Ag85A gene and subsequently challenged with M. marinum were investigated...
  81. ncbi Laboratory maintenance of Mycobacterium marinum
    Lian-Yong Gao
    University of Maryland, College Park, Maryland, USA
    Curr Protoc Microbiol . 2005
    ..marinum and the methods for processing M. marinum for infection assays. Important parameters for culturing and maintaining M. marinum and its processing for infection assays are discussed in detail...
  82. ncbi Illuminating the black box of TNF action in tuberculous granulomas
    Elizabeth A Miller
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:175-7. 2008
    ..In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis...
  83. ncbi First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium
    Pieter Stragier
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium
    FEMS Microbiol Lett 286:93-5. 2008
    In the past few years, a mycolactone-producing subgroup of the Mycobacterium marinum complex has been identified and analyzed. These IS2404-positive species cause pathology in frogs and fish...
  84. ncbi Biochemical, molecular, and virulence characteristics of select Mycobacterium marinum isolates in hybrid striped bass Morone chrysops x M. saxatilis and zebrafish Danio rerio
    V E Ostland
    Kent SeaTech Corporation, 11125 Flintkote Ave, Suite J, San Diego, California 92121, USA
    Dis Aquat Organ 79:107-18. 2008
    A panel of 15 Mycobacterium marinum isolates was characterized by biochemical tests, sequencing the ribosomal DNA intergenic spacer (ITS) region and the heat shock protein 65 gene (hsp65) and pulsed-field gel electrophoresis (PFGE)...
  85. ncbi [Aquarium granuloma]
    C Mühlhoff
    Klinik für Allergologie und Dermatologie, Universitatsklinikum Aachen, Pauwelsstrabe 30, 52074, Aachen, Deutschland
    Hautarzt 59:460-3. 2008
  86. ncbi Rapid resolution of Mycobacterium marinum chronic skin infection during lenalidomide therapy for chronic lymphocytic leukemia
    Ahmed Awais
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, USA
    Clin Infect Dis 46:e69-71. 2008
    ..We report the rapid resolution of chronic Mycobacterium marinum infection in a patient following initiation of lenalidomide therapy for chronic lymphocytic leukemia.
  87. ncbi Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci
    Bonggoo Park
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Sciences Center, 467 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Infect Immun 76:3100-15. 2008
    We recently identified two loci, mel1 and mel2, that affect macrophage infection by Mycobacterium marinum. The ability of these loci to confer enhanced infection in trans is presumably due to gene dosage effects since their presence on ..
  88. ncbi The arthritic fisherman
    Kristina Roddy
    Department of Medicine, University of Maryland Medical Center and Baltimore Veterans Administration Hospital, Baltimore, MD 21201, USA
    Am J Med 121:287-9. 2008
  89. ncbi Severe sporotrichoid fish tank granuloma following infliximab therapy
    Efstathios Rallis
    Department of Dermatology, Army General Hospital, Athens
    Am J Clin Dermatol 8:385-8. 2007
    b>Mycobacterium marinum is an atypical mycobacterium usually found in non-chlorinated water. It rarely disseminates, except in the setting of a severely immunosuppressed patient, and usually follows a sporotrichotic type of distribution...
  90. ncbi Treatment of Mycobacterium marinum cutaneous infections
    Efstathios Rallis
    Army General Hospital, Department of Dermatology, 11 Pafsaniou street, 11635, Athens, Greece
    Expert Opin Pharmacother 8:2965-78. 2007
    b>Mycobacterium marinum is a non-tuberculous mycobacterium found in non-chlorinated water, with worldwide prevalence. It is the most common atypical Mycobacterium that causes opportunistic infection in humans...
  91. ncbi Local and disseminated infections caused by Mycobacterium marinum: an unusual cause of subcutaneous nodules
    Leena G Adhikesavan
    Department of Rheumatology, Geisinger Health System, Danville, PA 17822, USA
    J Clin Rheumatol 14:156-60. 2008
    b>Mycobacterium marinum is a free-living, nontuberculous, photochromogenic mycobacterium, which can cause opportunistic infections in humans...
  92. ncbi Don't forget the pets!
    Shaun W Smale
    Department of Rheumatology, Princess of Wales Hospital, Bridgend, South Wales, United Kingdom
    J Clin Rheumatol 13:100-1. 2007
  93. ncbi [Skin nodules and ulcers of the limbs in a patient with rheumatoid arthritis]
    W Bocher
    I Medizinische Klinik und Poliklinik der Johannes Gutenberg Universität Mainz, Germany
    Dtsch Med Wochenschr 127:735-8. 2002
    ....
  94. ncbi Mycobacterium marinum infection cured by photodynamic therapy
    Stine Regin Wiegell
    Arch Dermatol 142:1241-2. 2006
  95. ncbi The evolving story of Mycobacterium tuberculosis clade members detected in fish
    I M Kaattari
    Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
    J Fish Dis 29:509-20. 2006
    ..Thus, researchers must be aware of the variety of piscine isolates within the M. tuberculosis clade. This review summarizes the methods of detection and differentiation for this important group of mycobacteria...
  96. ncbi Immunogenic and protective effects of a DNA vaccine for Mycobacterium marinum in fish
    David J Pasnik
    Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM, Virginia-Polytechnic Institute and State University (VPI and SU, Duck Pond Drive, Blacksburg, VA 24061-0442, USA
    Vet Immunol Immunopathol 103:195-206. 2005
    ..Thus, a DNA vaccine was constructed using the Mycobacterium marinum Ag85A gene that encodes one of the major secreted fibronectin-binding proteins of Mycobacterium spp...
  97. ncbi [Skin infection caused by Mycobacterium marinum]
    Yvona Loveckova
    Institute of Microbiology, Faculty of Medicine UP Olomouc, 77515 Czech Republic
    Klin Mikrobiol Infekc Lek 10:30-2. 2004
    ..The authors describe a case of skin infection caused by M. marinum in a female patient with an appropriate case history. They emphasize the need of close cooperation of the clinician with a microbiologist when establishing the diagnosis...
  98. ncbi Mycobacterium marinum infection in a lung transplant recipient
    F Torres
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Heart Lung Transplant 20:486-9. 2001
    We report a case of Mycobacterium marinum infection in a lung transplant recipient who presented with nodules on the hand and forearm following exposure to fish-tank water of a superficial hand burn...
  99. ncbi [Sporotrichoid atypical mycobacterial infections. Antibiotic monotherapy]
    G Bormann
    Universitätsklinik und Poliklinik für Dermatologie und Venerologie der Martin Luther Universität Halle Wittenberg, Halle Saale
    Hautarzt 55:292-5. 2004
    ..If pathogen proof is obtained by PCR, antibiotic therapy should be based on the known sensitivity of the pathogen in question...
  100. ncbi Disseminated cutaneous Mycobacterium marinum infection in a patient with non-Hodgkin's lymphoma
    R Enzensberger
    Dept of Medical Microbiology, Johann Wolfgang Goethe University of Frankfurt am Main, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
    Infection 30:393-5. 2002
    ..After repeated investigations, the diagnosis of Mycobacterium marinum was established from skin biopsy by PCR and culture...
  101. ncbi [Cutaneous infection with Mycobacterium marinum. successful therapy with rifampicin and clarithromycin]
    R Brans
    , , Aachen
    Hautarzt 55:76-9. 2004
    We report on two male patients with cutaneous Mycobacterium marinum infection. After the diagnosis was established by culture, therapy with rifampicin and clarithromycin over a period of three months led to remarkable improvement.

Research Grants67

  1. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2005
    The mycobacterial species, Mycobacterium marinum, is a marine pathogen that infects poikilothermic animals such as fish and frogs and will also infect humans. M...
  2. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  3. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  4. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2010
    ..between pathogenic mycobacteria and host immunity, we will use a closely related pathogenic species Mycobacterium marinum. M...
  5. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2006
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  6. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2007
    ..To better understand the host responses to tuberculous infections, we will take advantage of the fact that Mycobacterium marinum, a close relative of M...
  7. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2009
    ..of tuberculosis in the context of host immunity, we will use a closely related pathogenic species Mycobacterium marinum, the agent of a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease ..
  8. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2010
    ..To better understand the host responses to tuberculous infections, we will take advantage of the fact that Mycobacterium marinum, a close relative of M...
  9. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2003
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  10. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2006
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  11. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2007
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  12. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1999
    ..He expects that these studies are to stimulate progress in medicine. ..
  13. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1980
    ....
  14. Antibacterial activities of natural minerals and alternative treatment for infect
    Shelley E Haydel; Fiscal Year: 2010
    ....
  15. Control of Diseases in Zebrafish Research Facilities
    MICHAEL LAWRENCE KENT; Fiscal Year: 2010
    ..PCR tests will be made for the virulent strains. Results will be quickly distributed to the zebrafish community through ZFIN, peer reviewed publications, and our web based manual on zebrafish diseases ..
  16. Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction
    Brian P Lazzaro; Fiscal Year: 2010
    ..REVISED PUBLIC HEALTH RELEVANCE STATEMENT SECTION Program Director/Principal Investigator (Last, First, Middle): Swain, Susan L. 1R01 AI076534-01A1 NO text ..
  17. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  18. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2007
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  19. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1993
    ..These studies are again expected to stimulate the progress in medicine...
  20. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2007
    ..These studies will provide clues for developing better antitumor drugs and/or will help to deliver a new anticancer drug to patients at an acceptable cost. ..
  21. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2007
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..