mycobacterium marinum

Summary

Summary: A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)

Top Publications

  1. ncbi Multicenter study of incidence of Mycobacterium marinum in humans in Spain
    M Casal
    Mycobacteria Reference Center, Faculty of Medicine, Cordoba University, Spain
    Int J Tuberc Lung Dis 5:197-9. 2001
  2. pmc Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 2:29-39. 2007
  3. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
  4. pmc Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA
    Science 327:466-9. 2010
  5. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
  6. pmc Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
  7. doi PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 73:329-40. 2009
  8. pmc Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
    Esther J M Stoop
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Dis Model Mech 4:526-36. 2011
  9. doi Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
    David M Tobin
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Cell Microbiol 10:1027-39. 2008
  10. pmc Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
    Timothy P Stinear
    Department of Microbiology, Monash University, Clayton 3800, Australia
    Genome Res 18:729-41. 2008

Research Grants

  1. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2005
  2. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2002
  3. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2001
  4. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2004
  5. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
  6. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2003
  7. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2002
  8. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2006
  9. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2003
  10. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2004

Detail Information

Publications221 found, 100 shown here

  1. ncbi Multicenter study of incidence of Mycobacterium marinum in humans in Spain
    M Casal
    Mycobacteria Reference Center, Faculty of Medicine, Cordoba University, Spain
    Int J Tuberc Lung Dis 5:197-9. 2001
    A retrospective survey was carried out on the epidemiological monitoring of the isolation incidence of Mycobacterium marinum in 21 laboratories, in an attempt to gain an insight into the frequency of its isolation in Spain...
  2. pmc Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 2:29-39. 2007
    ..Using the optically transparent and genetically tractable zebrafish embryo-Mycobacterium marinum model of tuberculosis, we have directly examined early infection in the presence and absence of ..
  3. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
    ..However, work in zebrafish infected with Mycobacterium marinum suggests that granulomas contribute to early bacterial growth...
  4. pmc Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA
    Science 327:466-9. 2010
    ..However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages ..
  5. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
    ..Adult zebrafish are naturally susceptible to tuberculosis caused by Mycobacterium marinum. Here, we exploit the optical transparency of zebrafish embryos to image the events of M...
  6. pmc Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
    ..We monitored transparent Mycobacterium marinum-infected zebrafish live to conduct a stepwise dissection of how TNF signaling operates in mycobacterial ..
  7. doi PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 73:329-40. 2009
    ..Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants showed that a number of ..
  8. pmc Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
    Esther J M Stoop
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Dis Model Mech 4:526-36. 2011
    ..We exploited the zebrafish embryo Mycobacterium marinum infection model to study initiation of granuloma formation and developed an in vivo screen to select for ..
  9. doi Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
    David M Tobin
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Cell Microbiol 10:1027-39. 2008
    ..b>Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms...
  10. pmc Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
    Timothy P Stinear
    Department of Microbiology, Monash University, Clayton 3800, Australia
    Genome Res 18:729-41. 2008
    b>Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M...
  11. ncbi Identification of Mycobacterium marinum 65 kD heat shock protein gene by polymerase chain reaction restriction analysis from lesions of swimming pool granuloma
    Lin Cai
    Department of Dermatology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 119:43-8. 2006
    ..Among NTM infections, Mycobacterium marinum (M. marinum) are mostly seen to cause skin infection...
  12. pmc PPE38 modulates the innate immune response and is required for Mycobacterium marinum virulence
    Dandan Dong
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai, China
    Infect Immun 80:43-54. 2012
    ..In this study, we isolated a transposon-inactivated PPE38 mutant of Mycobacterium marinum and characterized its phenotype...
  13. doi Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation
    Abdallah M Abdallah
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    J Immunol 187:4744-53. 2011
    ..proteins secreted by ESX-5 are not required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells. However, the M...
  14. pmc A mycobacterium ESX-1-secreted virulence factor with unique requirements for export
    Bryant McLaughlin
    Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e105. 2007
    ..Both the Mycobacterium marinum and the Mycobacterium tuberculosis genomes contain an extended region of difference 1 (extRD1) locus that ..
  15. pmc Polar localization of virulence-related Esx-1 secretion in mycobacteria
    Fredric Carlsson
    Department of Microbial Pathogenesis, Genentech Inc, South San Francisco, California, United States of America
    PLoS Pathog 5:e1000285. 2009
    The Esx-1 (type VII) secretion system is critical for virulence of both Mycobacterium tuberculosis and Mycobacterium marinum, and is highly conserved between the two species...
  16. pmc ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection
    Ingrid C Koo
    Program in Microbial Pathogenesis and Host Defense, University of California, San Fancisco, CA, USA
    Cell Microbiol 10:1866-78. 2008
    ..a virulence factor necessary for phagosome escape and host cell lysis by a contact-dependent haemolysin in Mycobacterium marinum. Here we show that ESX-1 from M. marinum and M...
  17. ncbi The complex relationship between mycobacteria and macrophages: it's not all bliss
    Sarah M Fortune
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 2:5-6. 2007
    ..show in a recent issue of Cell, there are both benefits and drawbacks for the pathogen in adopting this strategy, and some of our fundamental assumptions about how the host cell and bacterium interact might need to be reexamined...
  18. pmc Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas
    D M Bouley
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Infect Immun 69:7820-31. 2001
    b>Mycobacterium marinum causes long-term subclinical granulomatous infection in immunocompetent leopard frogs (Rana pipiens)...
  19. pmc Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin
    Jonathan M Solomon
    Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 71:3578-86. 2003
    b>Mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial ..
  20. pmc Role of the WASP family proteins for Mycobacterium marinum actin tail formation
    Luisa M Stamm
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:14837-42. 2005
    b>Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread...
  21. pmc Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts
    Monica Hagedorn
    Departement de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Science 323:1729-33. 2009
    ..This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells...
  22. ncbi Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Comp Immunol 32:36-49. 2008
    ..Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation.
  23. pmc Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole
    Jennifer Smith
    Department of Cell Biology and Molecular Genetics and Maryland Pathogens Research Institute, University of Maryland, College Park, Maryland 20742, USA
    Infect Immun 76:5478-87. 2008
    ..marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection...
  24. ncbi Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila
    Marc S Dionne
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Curr Biol 16:1977-85. 2006
    ..Here, we examine the pathogenesis associated with Mycobacterium marinum infection in the fly. M. marinum is closely related to M. tuberculosis, which causes tuberculosis in people...
  25. ncbi The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    J Immunol 181:7166-75. 2008
    ..To better understand the role of ESX-5 effector proteins in virulence, we analyzed the interactions of Mycobacterium marinum ESX-5 mutant with human macrophages (Mphi)...
  26. ncbi Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis
    Michael G Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    FEMS Microbiol Lett 225:177-82. 2003
    We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish (Danio rerio) for the study of mycobacterial disease...
  27. doi Mycobacterium marinum infections in transplant recipients: case report and review of the literature
    T K Pandian
    Mayo Medical School, Rochester, Minnesota 55905, USA
    Transpl Infect Dis 10:358-63. 2008
    Infections due to Mycobacterium marinum are rarely encountered following organ and tissue transplantation. Herein, we report a case of M...
  28. ncbi Mycobacterium marinum with different responses to second-generation tetracyclines
    Deborah L Cummins
    Department of Dermatology, Johns Hopkins, Baltimore, Maryland 21287 0900, USA
    Int J Dermatol 44:518-20. 2005
    Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials...
  29. ncbi Recurrent Mycobacterium marinum tenosynovitis of the wrist mimicking extraarticular synovial chondromatosis on MR images
    Edward Y Lee
    Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, MO, USA
    Skeletal Radiol 33:405-8. 2004
    ..We report a case of recurrent M. marinum infection involving the flexor tendons within the carpal tunnel in which the rice bodies were mistaken for synovial chondromatosis on MR images...
  30. ncbi A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion
    Lian Yong Gao
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Mol Microbiol 53:1677-93. 2004
    ..A screen of Mycobacterium marinum transposon mutant library led to isolation of eight mutants that failed to cause haemolysis, all of which ..
  31. ncbi Pulmonary infection due to Mycobacterium marinum in an immunocompetent patient
    Chih Cheng Lai
    Clin Infect Dis 40:206-8. 2005
  32. ncbi Pathogenesis of Mycobacterium spp. in zebrafish (Danio rerio) from research facilities
    Virginia Watral
    Center for Fish Disease Research, Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
    Comp Biochem Physiol C Toxicol Pharmacol 145:55-60. 2007
    ..United States: Mycobacterium abscessus, Mycobacterium peregrinum, Mycobacterium chelonae (2 isolates), and Mycobacterium marinum. We also included two isolates of M. marinum from other fishes...
  33. ncbi Identification of Mycobacterium marinum macrophage infection mutants
    Parmod K Mehta
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center, 471 Reynolds Medical Building, College Station, TX 77843, USA
    Microb Pathog 40:139-51. 2006
    b>Mycobacterium marinum is an important pathogen of humans, amphibians and fish. Most pathogenic mycobacteria, including M. marinum, infect, survive and replicate primarily intracellularly within macrophages...
  34. ncbi Treatment of Mycobacterium marinum cutaneous infections
    Efstathios Rallis
    Army General Hospital, Department of Dermatology, 11 Pafsaniou street, 11635, Athens, Greece
    Expert Opin Pharmacother 8:2965-78. 2007
    b>Mycobacterium marinum is a non-tuberculous mycobacterium found in non-chlorinated water, with worldwide prevalence. It is the most common atypical Mycobacterium that causes opportunistic infection in humans...
  35. pmc Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum
    Jia Yu
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Medical Microbiology, Fudan University, Shanghai, China
    Infect Immun 80:1381-9. 2012
    ..tuberculosis strains. In this study, we isolated seven mutants of Mycobacterium marinum deficient in PDIMs and/or PGLs in which multiple genes of the PDIM/PGL biosynthetic locus were disrupted ..
  36. pmc PPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics
    Hui Wang
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Proteome Res 12:2055-66. 2013
    ..The results of our systems investigation now indicate that there is cross-talk involving a broad range of diverse biological pathways/processes that coordinate the host response to M. marinum PPE38...
  37. doi Outbreak of a cutaneous Mycobacterium marinum infection in Jiangsu Haian, China
    Yumiao Feng
    Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing City, Jiangsu Province 210042, China
    Diagn Microbiol Infect Dis 71:267-72. 2011
    b>Mycobacterium marinum is a slow-growing mycobacterium. In November 2008, we diagnosed a patient with M. marinum infection who worked at a fish farm in Jiangsu Haian, China...
  38. pmc Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry as an alternative proteomics platform to ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry for samples of intermediate complexity
    Yihan Li
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Anal Chem 84:1617-22. 2012
    ..of a tryptic digest of a sample of intermediate protein complexity, the secreted protein fraction of Mycobacterium marinum. For electrophoretic analysis, 11 fractions were generated from the sample using reverse-phase liquid ..
  39. doi EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis
    Shilpa A Joshi
    Department of Microbial Pathogenesis, Genentech, South San Francisco, CA 94080, USA
    Chem Biol 19:372-80. 2012
    ..Key ESX-1 components include three ATPases, and EccA1 (Mycobacterium marinum MMAR_5443; M. tuberculosis Rv3868) is the least characterized. Here we show that M...
  40. ncbi Review article: Mycobacterium marinum infection of the hand and wrist
    Jason Pui yin Cheung
    Department of Orthopaedics and Traumatology, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    J Orthop Surg (Hong Kong) 18:98-103. 2010
    Misdiagnosis and delayed treatment of Mycobacterium marinum infection is common because of its diverse manifestations...
  41. doi Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components
    Astrid M van der Sar
    Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 46:2317-32. 2009
    ..outcomes: an acute disease with early lethality or a chronic disease with granuloma formation, caused by Mycobacterium marinum strains Mma20 and E11, respectively...
  42. ncbi Subcutaneous nodules with sporotrichoid spread
    Mark N Schwendiman
    Des Moines University College of Osteopathic Medicine and Surgery, Des Moines, Iowa, USA
    Dermatol Online J 15:11. 2009
    b>Mycobacterium marinum is an atypical mycobacterium found worldwide and associated with swimming pools and aquariums. Infections typically present with subcutaneous nodules and lymphangitis.
  43. pmc Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins
    Musa Sani
    Division of Cell Biology B6, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital NKI AVL, Amsterdam, The Netherlands
    PLoS Pathog 6:e1000794. 2010
    ..Further immunogenic and proteomic analyses revealed that Mycobacterium marinum capsule contains high amounts of proteins that are secreted via the ESX-1 pathway...
  44. ncbi Mycobacterium marinum skin infection with tenosynovitis successfully treated with doxycycline
    Filipa Osorio
    Hospital de Sao Joao E P E, Porto, Portugal
    Dermatol Online J 16:7. 2010
    Skin infection with Mycobacterium marinum can rarely spread to deeper structures, making it more difficult to treat. We report a case of a M...
  45. pmc Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum
    Peter Ankomah
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002487. 2012
    ..In this report, mathematical models and in vitro experiments with Mycobacterium marinum and five antimycobacterial drugs are used to quantitatively evaluate the pharmaco-, population and ..
  46. doi A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos
    Laeticia Alibaud
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS UMR 5235, Case 107, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    Mol Microbiol 80:919-34. 2011
    Infection of the zebrafish with Mycobacterium marinum is regarded as a well-established experimental model to study the pathogenicity of Mycobacterium tuberculosis. Herein, a M...
  47. doi Disseminated Mycobacterium marinum infection in a patient with rheumatoid arthritis receiving infliximab therapy
    Janine R Danko
    Infectious Diseases Directorate, Viral Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave, Room 3N25, Silver Spring, MD 20910, USA
    Scand J Infect Dis 41:252-5. 2009
    ..We present a case of a woman with severe rheumatoid arthritis on infliximab who developed multiple nodular skin lesions. Biopsies grew Mycobacterium marinum. New lesions developed through therapy, necessitating surgical debulking.
  48. ncbi Mycobacterium marinum infection in Taiwan
    Ting Shu Wu
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC
    J Microbiol Immunol Infect 35:42-6. 2002
    b>Mycobacterium marinum often causes skin infections, tenosynovitis, arthritis, and osteomyelitis, and occasionally results in severe disseminated infections in immunocompromised patients...
  49. doi Mycobacterium marinum infection complicated by anti-tumour necrosis factor therapy
    Jose M Ramos
    Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Alicante, Spain
    J Med Microbiol 59:617-21. 2010
    ..We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab...
  50. ncbi Mycobacterium marinum osteomyelitis of a long bone
    Manoj Sivan
    Department of Orthopaedics, Nuffield Orthopaedic Centre, Oxford, England, UK
    Joint Bone Spine 75:600-2. 2008
    b>Mycobacterium marinum can uncommonly cause osteomyelitis of small bones of extremities. The reported cases in literature are reviewed...
  51. doi Mycobacterium marinum infections in humans and tracing of its possible environmental sources
    Michal Slany
    Veterinary Research Institute, O I E Reference laboratories for Paratuberculosis and Avian Tuberculosis, Brno, Czech Republic
    Can J Microbiol 58:39-44. 2012
    ..Mycobacterium fortuitum , Mycobacterium gordonae , Mycobacterium kansasii , Mycobacterium mantenii , Mycobacterium marinum , and Mycobacterium peregrinum . The presence of M...
  52. pmc Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish
    Mataleena Parikka
    BioMediTech, University of Tampere, Tampere, Finland
    PLoS Pathog 8:e1002944. 2012
    ..zebrafish, we show that an experimental intraperitoneal infection with a low dose (≈ 35 bacteria) of Mycobacterium marinum, results in the development of a latent disease in most individuals...
  53. ncbi ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish
    Eveline M Weerdenburg
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands
    Cell Microbiol 14:728-39. 2012
    ..In this work, we studied the effects of ESX-5 in embryonic and adult zebrafish using Mycobacterium marinum. We found that ESX-5-deficient M. marinum was slightly attenuated in zebrafish embryos...
  54. pmc Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR_2343) protein
    Yoann Rombouts
    Universite de Lille 1, Unite de Glycobiologie Structurale et Fonctionnelle, F 59650 Villeneuve d Ascq, France
    J Biol Chem 286:33678-88. 2011
    ..the fine structure of the glycan backbone of lipooligosaccharides (LOS-I to LOS-IV) isolated from Mycobacterium marinum, a close relative of Mycobacterium tuberculosis...
  55. ncbi Experimental exposure of zebrafish, Danio rerio (Hamilton), to Mycobacterium marinum and Mycobacterium peregrinum reveals the gastrointestinal tract as the primary route of infection: a potential model for environmental mycobacterial infection
    M J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Fish Dis 30:587-600. 2007
    ..Danio rerio (Hamilton) were exposed by bath immersion and intubation to Mycobacterium marinum and Mycobacterium peregrinum isolates obtained from diseased zebrafish...
  56. pmc Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan
    Nicole N Driessen
    Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Microbiology 156:3492-502. 2010
    ..Here, we report that a third gene is involved, MMAR_2380, which is the Mycobacterium marinum orthologue of Rv1565c. MMAR_2380 encodes a predicted transmembrane acyltransferase. In M...
  57. pmc The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species
    Selvakumar Subbian
    Dept, Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center College of Medicine, College Station, TX 77843 1114, USA
    BMC Microbiol 7:4. 2007
    ..We recently identified a locus in Mycobacterium marinum, mel2, that plays a role during infection of macrophages...
  58. ncbi Mycobacterium marinum infections of the distal upper extremities: clinical course and imaging findings in two cases with delayed diagnosis
    Kimberly K Amrami
    Department of Radiology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Skeletal Radiol 32:546-9. 2003
    b>Mycobacterium marinum infections cause tenosynovitis of the distal upper extremities and develop as a consequence of skin abrasions acquired in contaminated water...
  59. ncbi Disseminated Mycobacterium marinum infection with extensive cutaneous eruption and bacteremia in an immunocompromised patient
    Markus Streit
    Department of Dermatology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Eur J Dermatol 16:79-83. 2006
    b>Mycobacterium marinum can cause fish tank granuloma (or swimming pool or aquarium granuloma) in immunocompetent patients...
  60. ncbi The secret lives of the pathogenic mycobacteria
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 57:641-76. 2003
    ..In addition, we highlight current controversies and unanswered questions in these areas...
  61. pmc Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival
    Lian Yong Gao
    Program in Host Pathogen Interactions, University of California, San Francisco, 94143, USA
    Infect Immun 71:922-9. 2003
    ..b>Mycobacterium marinum has recently been used as a model for aspects of the pathogenesis of tuberculosis because of its close ..
  62. ncbi Mycobacterium marinum biofilm formation reveals cording morphology
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Microbiol Lett 257:43-9. 2006
    ..We assayed the NTM bacterium Mycobacterium marinum strain 1218R, a fish outbreak isolate, for biofilm formation on different surfaces over time using three ..
  63. ncbi Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab
    J C Fallon
    Department of Dermatology, Beaumont Hospital, Dublin, Ireland
    Clin Exp Dermatol 33:43-5. 2008
    ..We report sporotrichoid spread of Mycobacterium marinum in a 37-year-old woman with Crohn's disease, who had been receiving infliximab infusions for 2 years...
  64. ncbi A prolonged case of Mycobacterium marinum flexor tenosynovitis: radiographic and histological correlation, and review of the literature
    M D Wongworawat
    USC University Hospital, 1500 San Pablo Street, Los Angeles, CA 90033, USA
    Skeletal Radiol 32:542-5. 2003
    We report on a 30-year-old man with prolonged Mycobacterium marinum flexor tenosynovitis. Due to low clinical suspicion, diagnosis was not made until 8 years after initial presentation...
  65. doi MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish
    Jia Yu
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Medical Microbiology, Fudan University, 138 Yi Xue Yuan Road, Shanghai, China
    Microbes Infect 13:33-41. 2011
    ..In this study, we isolated a mutant of Mycobacterium marinum in which MMAR_2770, a previously uncharacterized gene encoding a predicted short-chain dehydrogenase/..
  66. pmc Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
    E Pagan-Ramos
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    J Bacteriol 180:4856-64. 1998
    ..In this work, we characterized the oxyR-ahpC and furA-katG loci in the nontuberculous pathogen Mycobacterium marinum. In contrast to Mycobacterium smegmatis and like Mycobacterium tuberculosis and Mycobacterium leprae, M...
  67. pmc Transposition of Tn5367 in Mycobacterium marinum, using a conditionally recombinant mycobacteriophage
    Jan Rybniker
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    J Bacteriol 185:1745-8. 2003
    b>Mycobacterium marinum is a close relative of the obligate human pathogen Mycobacterium tuberculosis. As with M. tuberculosis, M. marinum causes intracellular infection of poikilothermic vertebrates and skin infection in humans...
  68. pmc Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence
    Astrid M van der Sar
    Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Infect Immun 72:6306-12. 2004
    b>Mycobacterium marinum causes a systemic tuberculosis-like disease in a large number of poikilothermic animals and is used as a model for mycobacterial pathogenesis...
  69. ncbi Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection
    Monica Hagedorn
    Department de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Cell Microbiol 9:2716-33. 2007
    b>Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, provides a useful model to study the pathogenesis of tuberculosis in genetically tractable model organisms...
  70. doi Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum
    Jessica L Porter
    Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia
    Microbiology 155:1923-33. 2009
    ..of these two constructs permitted the two-step transfer of the entire 174 kb pMUM001 plasmid to Mycobacterium marinum, a rapidly growing non-mycolactone-producing mycobacterium that is a close genetic relative of M. ulcerans...
  71. ncbi LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum
    Adeline Burguière
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT
    J Biol Chem 280:42124-33. 2005
    ..Previous studies have shown that Mycobacterium marinum produces large amounts of a diacylglycosylphenolphthiocerol, "phenolic" glycolipid...
  72. ncbi Mycobacterial phenolic glycolipid inhibits phagosome maturation and subverts the pro-inflammatory cytokine response
    Nirmal Robinson
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    Traffic 9:1936-47. 2008
    ..We in this study characterize a glycolipid of Mycobacterium marinum identified through a screen of mutants disabled in inhibiting phagosome maturation to be phenolphthiocerol ..
  73. ncbi The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation
    Tracy Tan
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Cell Microbiol 8:1417-29. 2006
    ..In this study, we isolated a mutant of Mycobacterium marinum defective in the secretion of ESAT-6 and CFP-10...
  74. pmc Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor
    Marcus J Yip
    Department of Microbiology, Monash University, Wellington Road, Clayton 3800, Australia
    J Bacteriol 189:2021-9. 2007
    ..ulcerans and Mycobacterium marinum. Here, we show by multiple genetic methods, including multilocus sequence analysis and DNA-DNA ..
  75. pmc A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages
    Lian Yong Gao
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, 600 16th St, Campus Box 2140, San Francisco, CA 94143 2140, USA
    Infect Immun 74:1757-67. 2006
    ..We have found a Mycobacterium marinum locus of two genes that is required for both invasion and intracellular survival in macrophages...
  76. ncbi In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures
    Michael L Kent
    Department of Microbiology, Center for Fish Disease Research, Oregon State University, Corvallis, OR 97331 3804, USA
    FEMS Microbiol Lett 257:69-75. 2006
    b>Mycobacterium marinum can cause systemic infection in fishes and skin infection in humans. Most strains grow better at <37 degrees C, which can explain the rarity of infections in humans...
  77. pmc Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Infect Immun 74:3125-33. 2006
    ..understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. tuberculosis. erp-deficient M...
  78. pmc A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species
    Selvakumar Subbian
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center, 471 Reynolds Medical Building, College Station, TX 77843, USA
    Infect Immun 75:127-34. 2007
    ..We recently constructed a Mycobacterium marinum mel2 locus mutant, which is known to affect macrophage infection...
  79. pmc Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
    Timothy P Stinear
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75725 Paris Cedex 15, France
    Genome Res 17:192-200. 2007
    ..Comparisons with the recently completed 6.6-Mb genome of Mycobacterium marinum revealed >98% nucleotide sequence identity and genome-wide synteny. However, as well as the plasmid, M...
  80. ncbi Mycobacterium marinum: ubiquitous agent of waterborne granulomatous skin infections
    B Petrini
    Department of Clinical Microbiology, Karolinska University Hospital Solna and Karolinska Institutet, 17176, Stockholm, Sweden
    Eur J Clin Microbiol Infect Dis 25:609-13. 2006
    b>Mycobacterium marinum is a waterborne mycobacterium that commonly infects fish and amphibians worldwide...
  81. ncbi Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum
    Huiping Ren
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Microbiol 63:1345-59. 2007
    ..This is an important step in assessing the differential distribution of LOSs among Mycobacterium species and understanding the role of LOSs in mycobacterial virulence...
  82. pmc Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity
    Laura E Swaim
    Department of Microbiology, Box 357242, University of Washington, Seattle, WA 98195, USA
    Infect Immun 74:6108-17. 2006
    The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to tuberculosis caused by Mycobacterium marinum, a close genetic relative of the causative agent of human tuberculosis, Mycobacterium tuberculosis...
  83. pmc Interleukin-8 is differentially expressed by human-derived monocytic cell line U937 infected with Mycobacterium tuberculosis H37Rv and Mycobacterium marinum
    Chang Hwa Song
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Mun hwa dong, Jung ku, Daejeon 301 747, Republic of Korea
    Infect Immun 71:5480-7. 2003
    Although Mycobacterium marinum is closely related to Mycobacterium tuberculosis H37Rv genomically, the clinical outcome in humans is quite different for M. marinum and M. tuberculosis infections...
  84. pmc Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulcerans
    K Chemlal
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    J Clin Microbiol 40:2370-80. 2002
    ..a previous study with a set of temporally and geographically diverse Mycobacterium ulcerans (n = 29) and Mycobacterium marinum (n = 29) isolates (K. Chemlal, G. Huys, P.-A. Fonteyne, V. Vincent, A. G. Lopez, L. Rigouts, J. Swings, W...
  85. pmc Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection
    Kaman Chan
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:3920-5. 2002
    ..We analyzed the gene expression profile of Mycobacterium marinum, the cause of fish and amphibian tuberculosis, during its persistence in granulomas...
  86. ncbi Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium
    Luisa M Stamm
    Program in Host Pathogen Interactions, 600 16th Street, Genentech Hall N212, University of California, San Francisco, CA 94158, USA
    Microbes Infect 6:1418-28. 2004
    b>Mycobacterium marinum is being used increasingly as a model for understanding pathogenic mycobacteria. However, recently discovered differences between M. marinum and M...
  87. pmc Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis
    T Tønjum
    Section of Molecular Microbiology, Institute of Microbiology, University of Oslo, National Hospital, Norway
    J Clin Microbiol 36:918-25. 1998
    ..tuberculosis. M. marinum may be particularly useful in this regard since strains of this species grow much more rapidly than M. tuberculosis and yet can cause systemic disease in immunocompromised hosts...
  88. ncbi Superinfecting mycobacteria home to established tuberculous granulomas
    Christine L Cosma
    Department of Microbiology, University of Washington School of Medicine, Box 357242, Seattle, Washington 98195, USA
    Nat Immunol 5:828-35. 2004
    ..We show here that superinfecting Mycobacterium marinum traffic rapidly into preexisting granulomas, including their caseous (necrotic) centers, through specific ..
  89. ncbi Identification of Mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis
    Kristin M Ruley
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 232:75-81. 2004
    b>Mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related Mycobacterium species (outside the M. tuberculosis complex) to M. tuberculosis, the etiologic agent of human tuberculosis...
  90. ncbi The identification of Mycobacterium marinum genes differentially expressed in macrophage phagosomes using promoter fusions to green fluorescent protein
    L P Barker
    Microscopy Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Mol Microbiol 29:1167-77. 1998
    b>Mycobacterium marinum, like Mycobacterium tuberculosis, is a slow-growing pathogenic mycobacteria that is able to survive and replicate in macrophages...
  91. ncbi Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family
    L Ramakrishnan
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 288:1436-9. 2000
    ..We identified several genes preferentially expressed when Mycobacterium marinum, the cause of fish and amphibian tuberculosis, resides in host granulomas and/or macrophages...
  92. ncbi The Mycobacterium marinum G13 promoter is a strong sigma 70-like promoter that is expressed in Escherichia coli and mycobacteria species
    L P Barker
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Microscopy Branch, Hamilton, MT 59840, USA
    FEMS Microbiol Lett 175:79-85. 1999
    A Mycobacterium marinum promoter, designated G13, was isolated from a promoter-trap library as a constitutive producer of the mutant green fluorescent protein...
  93. pmc Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence
    T P Stinear
    Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Bacteriol 182:6322-30. 2000
    Previous studies of the 16S rRNA genes from Mycobacterium ulcerans and Mycobacterium marinum have suggested a very close genetic relationship between these species (99.6% identity)...
  94. pmc Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility
    Luisa M Stamm
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94158, USA
    J Exp Med 198:1361-8. 2003
    ..Here we show that Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of actively ..
  95. pmc Genotyping Mycobacterium ulcerans and Mycobacterium marinum by using mycobacterial interspersed repetitive units
    Pieter Stragier
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Bacteriol 187:1639-47. 2005
    ..MIRU typing has significant potential value for discriminating between reoccurrence and reinfection for M. ulcerans disease...
  96. ncbi Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Mol Immunol 42:1185-203. 2005
    The Mycobacterium marinum-zebrafish infection model was used in this study for analysis of a host transcriptome response to mycobacterium infection at the organismal level...
  97. ncbi Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates
    Alexandra Aubry
    Laboratorie de Bactériologie, Centre National de Référence pour la Surveillance des Infections à Myocobactéries et de leur Resistance aux Antituerculeux, Paris, France
    Arch Intern Med 162:1746-52. 2002
    b>Mycobacterium marinum is a nontuberculous mycobacterium responsible for skin infections. Although cases have been seldom reported, no series of M marinum infection has been recently reported and the treatment is not standardized.
  98. ncbi Biofilm formation and biocide susceptibility testing of Mycobacterium fortuitum and Mycobacterium marinum
    Elias Bardouniotis
    Department of Biological Sciences, University of Calgary, 2500 University Drive N W, Calgary, Alberta T2N 1N4, Canada
    Curr Microbiol 46:28-32. 2003
    ..This study examines the biofilm growth of Mycobacterium fortuitum and Mycobacterium marinum, using the MBEC trade mark assay system, and compares the susceptibility of planktonic and biofilm cells ..
  99. pmc Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones
    Martin Bråbäck
    Department of Medical Microbiology, Lund University, University Hospital, S 205 02 Malmo, Sweden
    Antimicrob Agents Chemother 46:1114-6. 2002
    The susceptibility pattern of Mycobacterium marinum was determined. Quinupristin-dalfopristin and telithromycin were less active than clarithromycin. Linezolid showed good antimicrobial activity at clinically achievable concentrations...
  100. ncbi Mycobacterium marinum infections of the upper extremity
    Christopher L Hess
    Division of Plastic Surgery, Medstar Georgetown University Hospital, Washington, DC 20007, USA
    Plast Reconstr Surg 115:55e-59e. 2005
    A significant number of patients infected with Mycobacterium marinum have been treated at the Curtis National Hand Center in Baltimore, Maryland. The purpose of this study was to review the authors' experience with M...
  101. ncbi New models for the study of Mycobacterium-host interactions
    Tamara C Pozos
    Department of Microbiology, Box 357242, 1959 Pacific Street, University of Washington Medical School, Seattle, Washington 98195, USA
    Curr Opin Immunol 16:499-505. 2004
    ....

Research Grants68

  1. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2005
    The mycobacterial species, Mycobacterium marinum, is a marine pathogen that infects poikilothermic animals such as fish and frogs and will also infect humans. M...
  2. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2002
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  3. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2001
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  4. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2004
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  5. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  6. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2003
    ..shown to be in specifically induced in macrophages in vitro and during granuloma formation in vivo in the Mycobacterium marinum-frog model...
  7. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  8. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  9. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  10. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  11. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  12. Entry Mechanisms of Mycobacterium marinum
    Jeffrey Cirillo; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Mycobacterium marinum is the causative agent of localized lesions in the extremities, commonly called swimming pool or aquarium granuloma...
  13. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2010
    ..between pathogenic mycobacteria and host immunity, we will use a closely related pathogenic species Mycobacterium marinum. M...
  14. The role of Mycobacterium marinum protein ESAT-6 in promoting granuloma formation
    Frances Chu; Fiscal Year: 2010
    ..Although traditionally thought to be a host-protective structure, recent evidence from the Mycobacterium marinum- zebrafish model of infection has demonstrated that mycobacteria exploit the developing granuloma as a ..
  15. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2004
    The mycobacterial species, Mycobacterium marinum, is a marine pathogen that infects poikilothermic animals such as fish and frogs and will also infect humans. M...
  16. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2007
    ..of tuberculosis in the context of host immunity, we will use a closely related pathogenic species Mycobacterium marinum, the agent of a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease ..
  17. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2005
    ..of tuberculosis in the context of host immunity, we will use a closely related pathogenic species Mycobacterium marinum, the agent of a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease ..
  18. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2004
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  19. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2010
    ..To better understand the host responses to tuberculous infections, we will take advantage of the fact that Mycobacterium marinum, a close relative of M...
  20. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2005
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  21. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2009
    ..To better understand the host responses to tuberculous infections, we will take advantage of the fact that Mycobacterium marinum, a close relative of M...
  22. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2003
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  23. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2005
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  24. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2006
    ..To better understand the host responses to tuberculous infections, we will exploit the fact that Mycobacterium marinum, a close relative of M...
  25. Host Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2007
    ..To better understand the host responses to tuberculous infections, we will take advantage of the fact that Mycobacterium marinum, a close relative of M...
  26. Linking the behavior of individual host cells to their transcriptional signatures
    Lalita Ramakrishnan; Fiscal Year: 2010
    ..My laboratory has developed zebrafish infection by Mycobacterium marinum as a powerful surrogate model for exploring tuberculosis pathogenesis...
  27. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2009
    ..of tuberculosis in the context of host immunity, we will use a closely related pathogenic species Mycobacterium marinum, the agent of a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease ..
  28. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2006
    ..of tuberculosis in the context of host immunity, we will use a closely related pathogenic species Mycobacterium marinum, the agent of a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease ..
  29. Biofilm formation in mycobacterial persistence and drug tolerance in vivo
    Lynn E Connolly; Fiscal Year: 2010
    ..Using a Mycobacterium marinum (MM)-zebrafish model of TB that mimics human disease, I propose to identify non-replicating subpopulations ..
  30. Biofilm formation in mycobacterial persistence and drug tolerance in vivo
    Lynn Connolly; Fiscal Year: 2009
    ..Using a Mycobacterium marinum (MM)-zebrafish model of TB that mimics human disease, I propose to identify non-replicating subpopulations ..
  31. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2006
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  32. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2007
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  33. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2003
    ..and location will be measured for several bacteria that cause infections of Drosophila macrophages (Mycobacterium marinum, Salmonella typhimurium, Listeria monocytogenes)...
  34. Antibacterial activities of natural minerals and alternative treatment for infect
    SHELLEY HAYDEL; Fiscal Year: 2009
    ....
  35. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1990
    ..These studies are again expected to stimulate the progress in medicine...
  36. Control of Diseases in Zebrafish Research Facilities
    MICHAEL LAWRENCE KENT; Fiscal Year: 2010
    ..PCR tests will be made for the virulent strains. Results will be quickly distributed to the zebrafish community through ZFIN, peer reviewed publications, and our web based manual on zebrafish diseases ..
  37. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1992
    ..These studies are again expected to stimulate the progress in medicine...
  38. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1993
    ..These studies are again expected to stimulate the progress in medicine...
  39. Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction
    Brian P Lazzaro; Fiscal Year: 2010
    ..REVISED PUBLIC HEALTH RELEVANCE STATEMENT SECTION Program Director/Principal Investigator (Last, First, Middle): Swain, Susan L. 1R01 AI076534-01A1 NO text ..
  40. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2005
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  41. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2009
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  42. Control of Diseases in Zebrafish Research Facilities
    Michael Kent; Fiscal Year: 2009
    ..PCR tests will be made for the virulent strains. Results will be quickly distributed to the zebrafish community through ZFIN, peer reviewed publications, and our web based manual on zebrafish diseases ..
  43. Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction
    BRIAN LAZZARO; Fiscal Year: 2009
    ..REVISED PUBLIC HEALTH RELEVANCE STATEMENT SECTION Program Director/Principal Investigator (Last, First, Middle): Swain, Susan L. 1R01 AI076534-01A1 NO text ..
  44. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1980
    ....
  45. Antibacterial activities of natural minerals and alternative treatment for infect
    Shelley E Haydel; Fiscal Year: 2010
    ....
  46. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  47. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2004
    ..These studies will provide clues for developing better antitumor drugs and/or will help to deliver a new anticancer drug to patients at an acceptable cost. ..
  48. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2003
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  49. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2001
    ..These studies are again expected to stimulate progress in medicine. ..
  50. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2006
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  51. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 1999
    ..He expects that these studies are to stimulate progress in medicine. ..
  52. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2006
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  53. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2004
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  54. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2007
    ..These studies will provide clues for developing better antitumor drugs and/or will help to deliver a new anticancer drug to patients at an acceptable cost. [unreadable] [unreadable]..
  55. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2007
    ..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  56. CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIES
    Michael Kent; Fiscal Year: 2008
    ..In addition, we have developed a web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
  57. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2008
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  58. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2007
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  59. Control of Diseases in Zebrafish Research Facilities
    Michael Kent; Fiscal Year: 2008
    ..PCR tests will be made for the virulent strains. Results will be quickly distributed to the zebrafish community through ZFIN, peer reviewed publications, and our web based manual on zebrafish diseases ..