fusobacterium necrophorum

Summary

Summary: A species of gram-negative, non-spore-forming bacteria isolated from the natural cavities of man and other animals and from necrotic lesions, abscesses, and blood.

Top Publications

  1. ncbi [Lemierre's syndrome: literature review]
    C A Righini
    Service d ORL et de Chirurgie Cervico faciale
    Ann Otolaryngol Chir Cervicofac 123:179-88. 2006
  2. ncbi The evolution of Lemierre syndrome: report of 2 cases and review of the literature
    Julio A Chirinos
    Department of Medicine, University of Miami School of Medicine, FL, USA
    Medicine (Baltimore) 81:458-65. 2002
  3. ncbi Lemierre's syndrome
    David Kirsch
    Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, USA
    Ear Nose Throat J 83:806. 2004
  4. pmc Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome
    Terry Riordan
    Microbiology Department, Royal Devon and Exeter Foundation Trust, Exeter, United Kingdom
    Clin Microbiol Rev 20:622-59. 2007
  5. pmc Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemièrre's syndrome
    Karin Holm
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Infect Immun 79:3284-90. 2011
  6. ncbi Similar recovery rates of Fusobacterium necrophorum from recurrently infected and non-infected tonsils
    Tejs Ehlers Klug
    Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Dan Med Bull 58:A4295. 2011
  7. ncbi Immunogenicity and protective effects of truncated recombinant leukotoxin proteins of Fusobacterium necrophorum in mice
    Sanjeev Kumar Narayanan
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 305 Coles Hall, Manhattan, KS 66506 5606, USA
    Vet Microbiol 93:335-47. 2003
  8. doi Variation in Fusobacterium necrophorum strains present on the hooves of footrot infected sheep, goats and cattle
    Huitong Zhou
    Agriculture and Life Sciences Division, PO Box 84, Lincoln University, Lincoln 7647, New Zealand
    Vet Microbiol 135:363-7. 2009
  9. doi An indirect ELISA for serodiagnosis of cattle footrot caused by Fusobacterium necrophorum
    D H Guo
    College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing High tech Industrial Development Zone, Daqing, PR China
    Anaerobe 16:317-20. 2010
  10. doi Frequency, microbial interactions, and antimicrobial susceptibility of Fusobacterium nucleatum and Fusobacterium necrophorum isolated from primary endodontic infections
    Rogerio C Jacinto
    Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental School, University of Campinas, UNICAMP, Piracicaba, SP, Brazil
    J Endod 34:1451-6. 2008

Research Grants

  1. CHARACTERIZATION OF VIRULENCE FACTORS OF F. NECROPHORUM
    HENRY BJORNSON; Fiscal Year: 1980
  2. Measuring Quality - The Impact of Patient Complexity
    Robert Centor; Fiscal Year: 2007
  3. Clinical Investigation in Pediatric Thrombosis
    Neil Goldenberg; Fiscal Year: 2007
  4. Clinical Investigation in Pediatric Thrombosis
    Neil Goldenberg; Fiscal Year: 2008

Detail Information

Publications191 found, 100 shown here

  1. ncbi [Lemierre's syndrome: literature review]
    C A Righini
    Service d ORL et de Chirurgie Cervico faciale
    Ann Otolaryngol Chir Cervicofac 123:179-88. 2006
    ..Our aim was to recall the pathogenesis, clinic aspects and therapeutic options for Lemierre's syndrome...
  2. ncbi The evolution of Lemierre syndrome: report of 2 cases and review of the literature
    Julio A Chirinos
    Department of Medicine, University of Miami School of Medicine, FL, USA
    Medicine (Baltimore) 81:458-65. 2002
    ..A high degree of clinical suspicion is necessary for diagnosis. Fusobacterium necrophorum is the usual etiologic agent. The disease progresses in several steps...
  3. ncbi Lemierre's syndrome
    David Kirsch
    Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, USA
    Ear Nose Throat J 83:806. 2004
  4. pmc Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome
    Terry Riordan
    Microbiology Department, Royal Devon and Exeter Foundation Trust, Exeter, United Kingdom
    Clin Microbiol Rev 20:622-59. 2007
    Human infection with Fusobacterium necrophorum usually involves F. necrophorum subsp. funduliforme rather than F. necrophorum subsp. necrophorum, which is a common pathogen in animals...
  5. pmc Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemièrre's syndrome
    Karin Holm
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Infect Immun 79:3284-90. 2011
    b>Fusobacterium necrophorum causes Lemièrre's syndrome, a serious disease with septic thrombophlebitis of the internal jugular vein, pulmonary involvement, and systemic inflammation...
  6. ncbi Similar recovery rates of Fusobacterium necrophorum from recurrently infected and non-infected tonsils
    Tejs Ehlers Klug
    Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Dan Med Bull 58:A4295. 2011
    Recent studies implicate the presence of Fusobacterium necrophorum (FN) in recurrent tonsillitis (RT), acute tonsillitis and peritonsillar abscess...
  7. ncbi Immunogenicity and protective effects of truncated recombinant leukotoxin proteins of Fusobacterium necrophorum in mice
    Sanjeev Kumar Narayanan
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 305 Coles Hall, Manhattan, KS 66506 5606, USA
    Vet Microbiol 93:335-47. 2003
    b>Fusobacterium necrophorum, a gram-negative, anaerobic and rod-shaped bacterium, is generally an opportunistic pathogen and causes a wide variety of necrotic infections in animals and humans...
  8. doi Variation in Fusobacterium necrophorum strains present on the hooves of footrot infected sheep, goats and cattle
    Huitong Zhou
    Agriculture and Life Sciences Division, PO Box 84, Lincoln University, Lincoln 7647, New Zealand
    Vet Microbiol 135:363-7. 2009
    ..nodosus) and Fusobacterium necrophorum (F. necrophorum) are thought to be involved in the etiology of this disease...
  9. doi An indirect ELISA for serodiagnosis of cattle footrot caused by Fusobacterium necrophorum
    D H Guo
    College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing High tech Industrial Development Zone, Daqing, PR China
    Anaerobe 16:317-20. 2010
    A serodiagnostic ELISA (rL-ELISA) using recombinant truncated leukotoxin protein PL2 (aa 311-644) of Fusobacterium necrophorum as antigen was developed for detection of antibodies against F. necrophorum from cattle footrot...
  10. doi Frequency, microbial interactions, and antimicrobial susceptibility of Fusobacterium nucleatum and Fusobacterium necrophorum isolated from primary endodontic infections
    Rogerio C Jacinto
    Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental School, University of Campinas, UNICAMP, Piracicaba, SP, Brazil
    J Endod 34:1451-6. 2008
    This study assessed the prevalence and microbial interactions of Fusobacterium nucleatum and Fusobacterium necrophorum in primary endodontic infections from a Brazilian population and their antimicrobial susceptibility to some ..
  11. ncbi A 21-year-old man with fever and sore throat rapidly progressive to hemoptysis and respiratory failure. Diagnosis: Lemierre syndrome with Fusobacterium necrophorum sepsis
    Matthew Jankowich
    Division of Pulmonary, Critical Care and Sleep Medicine, Rhode Island Hospital, Brown Medical School, Department of Pulmonary, Critical Care and Sleep Medicine, Providence, RI 02903, USA
    Chest 132:1706-9. 2007
  12. ncbi Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCR
    A Jensen
    Department of Clinical Microbiology, Viborg Hospital, Viborg, Denmark
    Clin Microbiol Infect 13:695-701. 2007
    ..with non-streptococcal tonsillitis (NST) and 92 healthy controls were examined for the presence of Fusobacterium necrophorum DNA using a novel TaqMan-based real-time quantitative PCR assay for F. necrophorum subspecies...
  13. ncbi Fusobacterium necrophorum- detection and identification on a selective agar
    Steffen Bank
    Department of Clinical Microbiology, Viborg Hospital, Denmark
    APMIS 118:994-9. 2010
    Within the last decade, Fusobacterium necrophorum subsp. funduliforme has been considered a clinically important pathogen causing pharyngitis especially in adolescents and young adults. F...
  14. ncbi Lemierre's syndrome and other disseminated Fusobacterium necrophorum infections in Denmark: a prospective epidemiological and clinical survey
    L Hagelskjaer Kristensen
    Department of Clinical Microbiology, Viborg Hospital, Heibergs Alle 4, Viborg, Denmark
    Eur J Clin Microbiol Infect Dis 27:779-89. 2008
    In a 3-year prospective study, all cases of disseminated Fusobacterium necrophorum infections found in Denmark from 1998 to 2001 were analysed, with the aim of describing the epidemiology and clinical features of the variants of Lemierre'..
  15. ncbi Human infections with Fusobacterium necrophorum
    Jon S Brazier
    Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK
    Anaerobe 12:165-72. 2006
    b>Fusobacterium necrophorum is a Gram-negative anaerobic bacillus that can be a primary pathogen causing either localised abscesses and throat infections or systemic life-threatening disease. Systemic infections due to F...
  16. doi Acute phase response in lame cattle with interdigital dermatitis
    S Nazifi
    Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    World J Microbiol Biotechnol 28:1791-6. 2012
    ..None of the colonies on enriched blood agar was identified as Fusobacterium necrophorum. Four (26...
  17. ncbi Prevalence of Fusobacterium necrophorum and other upper respiratory tract pathogens isolated from throat swabs
    A Batty
    Department of Clinical Microbiology, University College London Hospitals, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T 4JF
    Br J Biomed Sci 62:66-70. 2005
    b>Fusobacterium necrophorum, an anaerobic, Gram-negative rod, has been identified recently as a significant cause of persistent sore throat syndrome (PSTS)...
  18. ncbi Respiratory failure and hypercoagulability in a toddler with Lemierre's syndrome
    Tal Schmid
    Pediatric Intensive Care Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatrics 115:e620-2. 2005
    ..Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and ..
  19. ncbi Detection of antibodies against Fusobacterium necrophorum and Porphyromonas levii-like species in dairy cattle with papillomatous digital dermatitis
    Kyaw Kyaw Moe
    Laboratory of Veterinary Public Health, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    Microbiol Immunol 54:338-46. 2010
    ..Moreover, 16S rRNA genes of Fusobacterium necrophorum and Porphyromonas levii-like species were detected in the lesions...
  20. ncbi Dichelobacter nodosus, Fusobacterium necrophorum and the epidemiology of footrot
    Grant Bennett
    Agriculture and Life Sciences Division, P O Box 84, Lincoln University, Lincoln 7647, New Zealand
    Anaerobe 15:173-6. 2009
    ..nodosus) or Fusobacterium necrophorum (F. necrophorum) species were present on each swab...
  21. ncbi Increased diagnosis of Lemierre syndrome and other Fusobacterium necrophorum infections at a Children's Hospital
    Susan Ramirez
    Department of Internal Medicine, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Pediatrics 112:e380. 2003
    To assess the apparent increase in the diagnosis of Lemierre syndrome (LS) and other Fusobacterium necrophorum infections at a large children's hospital...
  22. ncbi Complicated otitis media caused by Fusobacterium necrophorum
    W Giridharan
    Department of Otolaryngology, Alder Hey Children s Hospital, Liverpool, UK
    J Laryngol Otol 118:50-3. 2004
    b>Fusobacterium necrophorum is implicated as an aetiological agent in a variety of necrotic diseases, such as Lemièrre's syndrome (LS) in humans...
  23. ncbi Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice
    S H Aliyu
    Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 53:1029-35. 2004
    b>Fusobacterium necrophorum is recognized as the cause of a severe life-threatening illness characterized by bacteraemia with metastatic abscesses following an acute sore throat (Lemierre's disease). However, the importance of F...
  24. ncbi Fusobacterium necrophorum infection associated with portal vein thrombosis
    Michelle R Redford
    Department of Medicine, South Tyneside NHS Foundation Trust, South Tyneside District Hospital, Harton Lane, South Shields, Tyne and Wear NE34 0PL, UK
    J Med Microbiol 54:993-5. 2005
    ..upper respiratory tract or gastrointestinal infection who developed portal vein thrombosis secondary to Fusobacterium necrophorum septicaemia. The patient responded well to systemic antibiotic therapy. The implications of F...
  25. ncbi Factor H binding as a complement evasion mechanism for an anaerobic pathogen, Fusobacterium necrophorum
    Nathalie Friberg
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Immunol 181:8624-32. 2008
    b>Fusobacterium necrophorum subspecies funduliforme is an obligate anaerobic Gram-negative rod causing invasive infections such as the life-threatening Lemierre's syndrome (sore throat, septicemia, jugular vein thrombosis, and disseminated ..
  26. ncbi Fusobacterium necrophorum-induced sepsis: an unusual case of Lemierre's syndrome
    P M Kuduvalli
    Department of Anaesthesia and Intensive Care Medicine, Royal Liverpool University Hospital, Liverpool, UK
    Acta Anaesthesiol Scand 49:572-5. 2005
    ..The causative organisms are the anaerobic fusobacteria, most commonly Fusobacterium necrophorum. We describe the evaluation, therapeutic interventions and management of a patient with Lemierre's ..
  27. ncbi Update on the taxonomy and clinical aspects of the genus fusobacterium
    Diane M Citron
    R M Alden Research Laboratory, Santa Monica, CA, 90404, USA
    Clin Infect Dis 35:S22-7. 2002
    ..Two subspecies have been described for Fusobacterium necrophorum, and a new species, Fusobacterium equinum, which is related to F...
  28. ncbi A six-month audit of the isolation of Fusobacterium necrophorum from patients with sore throat in a district general hospital
    J A Amess
    Department of Medical Microbiology, District General Hospital, Eastbourne, East Sussex, UK
    Br J Biomed Sci 64:63-5. 2007
    b>Fusobacterium necrophorum is an obligate anaerobe believed to be a member of the normal flora of the human oropharangeal and urogenital tract...
  29. ncbi Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre's disease
    Antonia Batty
    Department of Clinical Microbiology, University College London Hospitals, Windeyer Building of Medical Sciences, 46, Cleveland St, London W1T 4JF, UK
    J Infect 51:299-306. 2005
    b>Fusobacterium necrophorum is a well established cause of Lemierre's disease (LD); a syndrome characterised by severe sore throat, septicaemia, multiple abscesses and jugular vein thrombosis...
  30. ncbi Fusobacterium necrophorum infections in England and Wales 1990-2000
    J S Brazier
    Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff
    J Med Microbiol 51:269-72. 2002
    In response to a marked increase in both the number of Fusobacterium necrophorum bacteraemia reports to the PHLS Communicable Disease Surveillance Centre and the number of F...
  31. pmc A 12-year-old girl with pharyngitis, meningitis and sinovenous thrombosis
    Jacob L Jaremko
    University of Alberta, Edmonton, Alta
    CMAJ 169:811-2. 2003
  32. ncbi [Septic thrombophlebitis of the internal jugular vein due to Fusobacterium necrophorum (Lemierre's syndrome): case report and review of literature]
    F Ianniello
    , Presidio Ospedaliero di Dolo VE, Azienda Sanitaria Locale n 13, Riviera del Brenta
    Acta Otorhinolaryngol Ital 18:332-7. 1998
    ..It is usually due to Fusobacterium necrophorum. Although Lemierre's syndrome is rare, it is potentially fatal...
  33. ncbi Cerebral infarct and meningitis secondary to Lemierre's syndrome
    Jamie R Bentham
    Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
    Pediatr Neurol 30:281-3. 2004
    The case is reported of a young man with Fusobacterium necrophorum septicemia who developed cavernous sinus thrombosis, meningitis, carotid artery stenosis and stroke...
  34. ncbi Lemierre's syndrome associated with consumption coagulopathy and acute renal failure: a case report
    S Georgopoulos
    ENT Department, Elpis General Hospital, Athens, Greece
    J Laryngol Otol 122:527-30. 2008
    ..Respiratory deficiency and renal impairment are often reported in patients suffering from Lemierre's syndrome...
  35. ncbi Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infections
    Roberto Manfredi
    Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
    Scand J Infect Dis 36:523-4. 2004
    Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency...
  36. ncbi A case of the otogenic variant of Lemierre's syndrome with atypical sequelae and a review of pediatric literature
    Tami Masterson
    Department of Pediatrics, The Stollery Children s Hospital, Edmonton, Alta, Canada
    Int J Pediatr Otorhinolaryngol 69:117-22. 2005
    ..The literature indicates that pediatric cases are a minority and enforces that successful management rests on awareness of the condition, vigil and promptness of communication of a multidisciplinary pediatric team...
  37. ncbi Lemierre syndrome: two cases and a review
    Mohammed Iqbal Syed
    Department of Otolaryngology, Royal Alexandra Hospital, Paisley, United Kingdom
    Laryngoscope 117:1605-10. 2007
    ..The usual organism is Fusobacterium necrophorum. Lemierre syndrome, not so long ago labeled as the "forgotten disease," is on the rise...
  38. ncbi Lemierre's syndrome: three cases and a review
    Hans Dool
    Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur Arch Otorhinolaryngol 262:651-4. 2005
    ..The causative microorganism is most often Fusobacterium necrophorum. We present three patients with Lemierre's syndrome who presented to the Leiden University Medical ..
  39. ncbi Lemierre's syndrome: how a sore throat can end in disaster
    Petros D Karkos
    Department of Otolaryngology and Head and Neck Surgery, Leighton Hospital, Crewe, UK
    Eur J Emerg Med 11:228-30. 2004
    ..We present a case report and review the literature...
  40. ncbi Cerebral infarctions and brain abscess due to Lemierre syndrome
    Yoko Shibasaki Warabi
    Department of Neurology, Niigata City General Hospital
    Intern Med 44:653-6. 2005
    ....
  41. ncbi [Sepsis caused by Fusobacterium necrophorum (Lemierre syndrome): a rare complication of acute pharyngotonsilitis]
    Marta Perović
    Klinika za infektivne bolesti Dr Fran Mihaljević, Zagreb, Hrvatska
    Acta Med Croatica 60:509-12. 2006
    ..The patient was treated with clindamycin for five weeks and recovered completely...
  42. ncbi Lemierre syndrome complicated by cavernous sinus thrombosis, the development of subdural empyemas, and internal carotid artery narrowing without cerebral infarction. Case report
    Franklin Westhout
    Department of Neurosurgery, School of Medicine, University of California, Irvine, USA
    J Neurosurg 106:53-6. 2007
    ..Cultures of samples from the blood proved positive for the presence of Fusobacterium necrophorum. The patient underwent unilateral tonsillectomy, drainage of the peritonsillar abscess, and a ..
  43. pmc Lemierre's syndrome and genetic polymorphisms: a case report
    Jean Michel Constantin
    Adult Intensive Care Unit, Department of Anesthesiology and Intensive Care, University Hospital of Clermont Ferrand, Hotel Dieu Hospital, F 63058 Clermont Ferrand, France
    BMC Infect Dis 6:115. 2006
    ..Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host detection of pathogen or the resultant systemic reaction...
  44. ncbi Outcome of pulmonary function in Lemierre's disease-associated acute respiratory distress syndrome
    Jill M Cholette
    University of Rochester, Rochester, New York, USA
    Pediatr Pulmonol 42:389-92. 2007
    ..We describe convalescent pulmonary function in two survivors of Lemierre's disease-associated ARDS, suggesting that the subset of Lemierre's syndrome induced ARDS survivors have an excellent long-term pulmonary prognosis...
  45. ncbi Lemierre's--the sinister sore throat
    L M Brown
    Department of ENT Surgery, Princess Alexandra Hospital, Brisbane, Australia
    J Laryngol Otol 121:692-4. 2007
    ..Discussed are aspects of clinical presentation, diagnosis and management issues...
  46. ncbi [Lemierre's syndrome and Mycoplasma pneumoniae]
    M Rivero Marcotegui
    Servicio de Medicina Interna, Clinica Ubarmin, Elcano
    An Med Interna 22:541-3. 2005
    ..A 16-year-old girl with trombophlebitis of the left jugular vein, Fusobacterium necrophorum bacteremia and septic emboli in the lung requiring mechanical ventilation due to severe respiratory ..
  47. ncbi Lemierre's syndrome: an unusual manifestation of spinal infection
    D Park
    The Royal Hospital, Brockley Hill, London, England
    J Bone Joint Surg Br 88:261-2. 2006
    ..We report a case of Lemierre's syndrome complicated by an epidural abscess. This manifestation of Lemierre's syndrome has not been described previously...
  48. ncbi Lemierre's syndrome
    Ming Yieh Peng
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Formos Med Assoc 104:764-7. 2005
    ..Intravenous ceftriaxone and metronidazole were given empirically. Fusobacterium necrophorum was isolated from the blood culture with susceptibility to metronidazole...
  49. ncbi [The Lemierre syndrome: a complicated oropharyngeal infection]
    C Libeer
    Acta Clin Belg 60:173-9. 2005
    ..This syndrome is caused by the strictly anaerobic gram-negative pathogen Fusobacterium necrophorum, sometimes in combination with other pathogens...
  50. ncbi Lemierre syndrome: presentation of three cases
    Paul Hong
    Faculty of Medicine, The University of Ottawa, Ottawa, Ontario
    J Otolaryngol 34:352-8. 2005
  51. ncbi [Lemierre's syndrome. An unusual variant]
    Lina Rosique López
    Servicio de Otorrinolaringologia, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Espana
    Acta Otorrinolaringol Esp 58:217-8. 2007
    ..In most cases the syndrome is caused by Fusobacterium necrophorum. This disease usually occurs in young healthy individuals with an oropharyngeal infection, implying high ..
  52. ncbi Lemierre's and Lemierre's-like syndromes in children: survival and thromboembolic outcomes
    Neil A Goldenberg
    Department of Pediatrics, University of Colorado Health Sciences Center, The Children s Hospital, Denver, Colorado, USA
    Pediatrics 116:e543-8. 2005
    ....
  53. ncbi Lemierre syndrome with jugular thrombophlebitis and cavitary pneumonia
    F Deridder
    Department of Radiology, Leiden University Hospital, Leiden, The Netherlands
    JBR-BTR 88:128-9. 2005
  54. ncbi Lemierre syndrome: an all-but-forgotten disease
    William T O'Brien
    David Grant U S Air Force Medical Center Travis AFB, CA 94535, USA
    AJR Am J Roentgenol 187:W324. 2006
  55. ncbi Lemierre's syndrome: a forgotten complication of oropharyngeal infection
    Shahid Ali Shah
    Department of ENT, Head and Neck Surgery, Ayub Medical College, Abbottabad
    J Ayub Med Coll Abbottabad 17:30-3. 2005
    ..b>Fusobacterium necrophorum is the usual etiologic agent. Lemierre's syndrome is not widely known by clinicians...
  56. ncbi Lemierre's syndrome: the controversy of anticoagulation
    K Sarah Hoehn
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 115:1415-6. 2005
  57. ncbi [Sore throat and a swollen neck: Lemierre's syndrome until proven otherwise]
    A J H M Fleskens
    afd Chirurgie, Maxima Medisch Centrum, locatie Veldhoven, Postbus 7777, 5500 MB Veldhoven
    Ned Tijdschr Geneeskd 150:2461-6. 2006
    ..Spread of organisms may lead to sepsis and organ failure. The main pathogen is Fusobacterium necrophorum. Early recognition is essential, since prompt antibiotic treatment is usually effective...
  58. ncbi Images in clinical medicine. Lemierre's Syndrome
    Clinton Lai
    Cannock Chase Hospital, Cannock WS11 2XY, United Kingdom
    N Engl J Med 350:e14. 2004
  59. doi Lemierre's syndrome following infectious mononucleosis
    Katja Garimorth
    Abteilung für Allgemeine Innere Medizin, Universitatsklinik fur Innere Medizin, Innsbruck, Austria
    Wien Klin Wochenschr 120:181-3. 2008
    ..Cultures of pleural fluids were positive for Fusobacterium necrophorum. In addition to multiple organ dysfunction syndrome (acute lung injury, acute renal failure, ..
  60. ncbi A case of Lemierre's syndrome
    Marek Ma
    University Hospital, Cincinnati, Ohio 45267 0769, USA
    Eur J Emerg Med 10:139-42. 2003
    ..Its incidence appears to be increasing. We present a case of Lemierre's syndrome, most notable for the patient's essentially benign physical examination and lack of clinical improvement with penicillin...
  61. ncbi [Diagnostic image (111). A dyspnoeic man with fever and a sore throat. Lemierre's syndrome]
    P L van Haelst
    Academisch Ziekenhuis, afd Interne Geneeskunde, Intensive Care Beademing, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 146:2027. 2002
    ..An 18-year-old man was admitted because of high fever, a sore throat and dyspnoea. Additional investigations revealed tonsillitis, lung abscesses and thrombophlebitis of the internal jugular vein. Lemierre's syndrome was diagnosed...
  62. ncbi [A throat infection with rapid deterioration]
    Ulf K Zätterstrøm
    Øre nese hals avdelingen, Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 122:1896-9. 2002
  63. ncbi Lemierre's syndrome: an unusual cause of sepsis and abdominal pain
    Sarah Hoehn
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, and the University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    Crit Care Med 30:1644-7. 2002
    ..To describe a patient with Lemierre's syndrome who presented with acute abdominal findings and to describe the evaluation and treatment of this syndrome...
  64. ncbi A critically ill young man with septic emboli to the lungs
    Steven T Dorsey
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Emerg Med 22:415-7. 2002
  65. ncbi Necrobacillosis--a resurgence?
    Andrea C Y Liu
    Department of Paediatric Radiology, Southampton General Hospital, Southampton, UK
    Clin Radiol 57:332-8. 2002
    Necrobacillosis is a rare life threatening illness caused by Fusobacterium necrophorum. It usually affects previously healthy adolescents and presents as symptomatic pharyngeal infection followed by bacteraemia and metastatic abscesses...
  66. ncbi Clinical problem solving: radiology. Radiology quiz case 2: Lemierre syndrome
    Mark A Zacharek
    Wayne State University, Detroit, MI, USA
    Arch Otolaryngol Head Neck Surg 128:597-9. 2002
  67. doi A previously healthy 15-year-old girl with high fever and progressive dyspnoea
    Eveline van Delft
    Paediatrics, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Eur J Pediatr 167:711-3. 2008
    ..Computed tomography (CT) scan showed progressive infiltrates in both lungs and pleural effusion. Blood culture led to the diagnosis. After changing antibiotics the patient slowly improved. Antibiotics were continued for several weeks...
  68. ncbi Lemierre's syndrome
    A Singhal
    Department of Surgery, Mount Sinai Medical Center, New York, NY 10029-6574, USA
    South Med J 94:886-7. 2001
    ..7 degrees F to 104.0 degrees F. She had an upper respiratory infection and swelling of the left side of the neck. She was diagnosed with Lemierre's syndrome...
  69. ncbi [Lemierre syndrome: unusual, but still possible]
    Matthieu Monge
    Service de Pneumologie et Unité de Réanimation Respiratoire, Centre Hospitalier Universitaire, Amiens
    Ann Med Interne (Paris) 154:263-6. 2003
    ..The most frequent causal germ on blood cultures is Fusobacterium necrophorum but other anaerobial bacteries can be found...
  70. doi Lemierre's syndrome: a forgotten disease
    Michael Joseph Monteiro
    Br J Oral Maxillofac Surg 46:324. 2008
  71. pmc Serious consequences of a sore throat
    M G Clarke
    Department of Intensive Care, Taunton and Somerset Hospital, Taunton, Somerset, UK
    Ann R Coll Surg Engl 85:242-4. 2003
    Lemierre's syndrome, caused by Fusobacterium necrophorum, is a potentially fatal sequelae of a sore throat characterised by septicaemia, internal jugular vein thrombophlebitis and metastatic abscesses...
  72. ncbi Lemierre's syndrome: a case report
    Martin R Velez
    Oral and Maxilofacial Surgery, Dwight D Eisenhower Army Medical Center, US Army DETAC, Fort Gordon, GA, USA
    J Oral Maxillofac Surg 61:968-71. 2003
  73. ncbi Hyperbaric oxygen (HBO2) in the treatment of Lemierre syndrome
    R Hodgson
    Spectrum Health Wound Healing Program, Spectrum Health, Grand Rapids, MI, USA
    Undersea Hyperb Med 30:87-91. 2003
    ..Subsequent to invasion and thrombophlebitis of the internal jugular vein, Fusobacterium necrophorum septicemia occurs, with rigors, high fever, and septic thromboembolism to peripheral sites, especially ..
  74. doi [Lemierre's syndrome from necrotizing pneumonia treated with extracorporeal CO2 removal]
    V Blasco
    Département d anesthésie et de réanimation, CHU de Nord, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 27:244-8. 2008
    ..An extracorporeal CO(2) removal was then carried out for 34-days duration. The patient was weaned from mechanical ventilation on day 68. He was then transferred to the chest surgery unit on day 83...
  75. ncbi Critical care nurses be aware: Lemierre's syndrome is on the rise
    Roseanne Jane
    Clinical Educator ICU, Gold Coast Hospital, QLD
    Aust Crit Care 16:126-32. 2003
    ..A case study of a young woman is presented to illustrate the complexity of the condition, and highlight how early diagnosis and prompt initiation of appropriate intravenous antibiotic therapy ensured a favourable clinical outcome...
  76. ncbi Lemierre's syndrome with septic shock caused by Fusobacterium necrophorum
    D Wang
    Children s Hospital of Western Ontario, University of Western Ontario, Schulich School of Medicine, London, Ontario, Canada
    Anaesth Intensive Care 35:796-801. 2007
    b>Fusobacterium necrophorum infections are rare. We report a 15-year-old male who presented with tachycardia, nausea, vomiting, diarrhoea and ankle pain. He rapidly deteriorated requiring ventilation and vasopressors...
  77. ncbi Internal jugular vein thrombophlebitis secondary to oropharyngeal infection with Fusobacterium necrophorum
    M B Khakhar
    Anaesthesia 59:302-3. 2004
  78. ncbi Lemierre's syndrome
    John Venglarcik
    Northeastern Ohio Universities, College of Medicine and Tod Children s Hospital, Youngstown, Ohio, USA
    Pediatr Infect Dis J 22:921-3. 2003
  79. ncbi [A case of Lemierre syndrome]
    Mitsutoshi Hayashi
    Department of Internal Medicine, Tokyo Women s Medical University, Daini Hospital, 2 1 10 Nishiogu, Arakawa ku, Tokyo, Japan, 116 8567
    Nihon Kokyuki Gakkai Zasshi 41:651-4. 2003
    ..Although Lemierre syndrome is a relatively uncommon disease with the potentially life-threatening complication of acute pharyngotonsillitis, this syndrome should be considered in cases of severe tonsillitis or pharyngitis...
  80. ncbi Clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis
    K Konigsson
    Department of Obstetrics and Gynaecology, Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SLU
    Reprod Domest Anim 36:247-56. 2001
    ..The predominant bacteria were Escherichia coli alpha-haemolytic streptococci, Fusobacterium necrophorum, Arcanobacterium (Actinomyces) pyogenes, Bacteroides spp., Pasteurella spp. and Proteus spp...
  81. pmc In vitro activity of gemifloxacin (SB 265805) against anaerobes
    E J Goldstein
    R M Alden Research Laboratory, Santa Monica University of California at Los Angeles Medical Center, Santa Monica, California 90404, USA
    Antimicrob Agents Chemother 43:2231-5. 1999
    ..06; for Clostridium ramosum (14), 0.25 and 8; for Fusobacterium nucleatum (12), 0.125 and 0.25; for Fusobacterium necrophorum (11), 0.25 and 0.5; for Fusobacterium varium (13), 0.5 and 1; for Fusobacterium spp...
  82. pmc Activities of gemifloxacin (SB 265805, LB20304) compared to those of other oral antimicrobial agents against unusual anaerobes
    E J Goldstein
    The R M Alden Research Laboratory, Santa Monica UCLA Medical Center, Santa Monica, California 90404, USA
    Antimicrob Agents Chemother 43:2726-30. 1999
    ..Fusobacterium naviforme and Fusobacterium necrophorum were also susceptible to </=2 microgram of gemifloxacin per ml, while Fusobacterium varium strains ..
  83. doi Effects of adding polyclonal antibody preparations on ruminal fermentation patterns and digestibility of cows fed different energy sources
    C T Marino
    Department of Animal Breeding and Nutrition, São Paulo State University FMVZ UNESP, Botucatu, Sao Paulo, Brazil
    J Anim Sci 89:3228-35. 2011
    ..polyclonal antibody preparation (PAP-MV) against the specific ruminal bacteria Streptococcus bovis, Fusobacterium necrophorum, Clostridium aminophilum, Peptostreptococcus anaerobius, and Clostridium sticklandii and monensin (MON) ..
  84. ncbi Rapid identification of non-sporing anaerobes using nuclear magnetic resonance spectroscopy and an identification strategy
    S Menon
    Department of Microbiology, Grant Medical College and Sir J J Hospital, Mumbai 400 008, Maharashatra, India
    Indian J Med Microbiol 25:330-5. 2007
    ....
  85. pmc Ammonia-hyperproducing bacteria from New Zealand ruminants
    G T Attwood
    AgResearch, Grasslands Research Centre, Palmerston North, New Zealand
    Appl Environ Microbiol 64:1796-804. 1998
    ..genus Peptostreptococcus, that D4 and D5 belonged to the family Bacteroidaceae, where D4 was similar to Fusobacterium necrophorum; and that C2 was most similar to an unidentified species from the genus Eubacterium...
  86. ncbi Effects of supplemental fat source on nutrient digestion and ruminal fermentation in steers
    S P Montgomery
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 1600, USA
    J Anim Sci 86:640-50. 2008
    ..Fat supplementation increased (P < 0.09) ruminal concentrations of Fusobacterium necrophorum. Duodenal flow of C18:3n-3 was greater (P < 0...
  87. ncbi Bacterial isolates associated with dystocia and retained placenta in iraqi buffaloes
    O I Azawi
    Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
    Reprod Domest Anim 43:286-92. 2008
    ..Among the isolates, Archanobacterium pyogenes, Fusobacterium necrophorum, Prevotella melaninogenicus and Staphylococcus aureus were the most prevalent isolates after 48 h of RP ..
  88. ncbi Fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis
    Xiang Y Han
    Department of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosurg 99:693-700. 2003
    ..The cases of five patients with fusobacterial brain abscess are presented. The authors discuss their attempt to determine the pathogenesis...
  89. ncbi [Clinical evaluation of lung abscess diagnosed by transtracheal aspiration]
    M Konishi
    Second Department of Internal Medicine, Nara Medical University
    Kansenshogaku Zasshi 72:1193-6. 1998
    ..Streptococcus pneumoniae, Streptococcus intermedius and other in aerobes, and Peptostreptococcus micros, Fusobacterium necrophorum, Prevotella melaninogenica and others in anaerobes...
  90. pmc Susceptibilities of bovine summer mastitis bacteria to antimicrobial agents
    H Jousimies-Somer
    Anaerobe Reference Laboratory, National Public Health Institute, Helsinki, Finland
    Antimicrob Agents Chemother 40:157-60. 1996
    ..acidominimus isolates, 2 Streptococcus spp., 15 Peptostreptococcus indolicus isolates, 10 Fusobacterium necrophorum isolates, and 12 isolates of anaerobic gram-negative rods) was determined by the agar dilution method...
  91. pmc Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells
    Veli Jukka Uitto
    University of Helsinki, Institute of Dentistry, PL 41, FIN 00014 University of Helsinki, Finland
    Infect Immun 73:1171-9. 2005
    ..Of the 13 anaerobic oral bacterial species, F. nucleatum and Fusobacterium necrophorum were among the best inducers of collagenase 3 mRNA levels, a powerful matrix metalloproteinase...
  92. ncbi The effect of statherin and its shortened analogues on anaerobic bacteria isolated from the oral cavity
    B Kochanska
    Department of Conservative Dentistry, Medical University of Gdansk, Poland
    Acta Microbiol Pol 49:243-51. 2000
    ..5 mg/ml), whereas the most susceptible to the peptides investigated were Fusobacterium necrogenes and Fusobacterium necrophorum strains: QYQQYTF, YQQYTF, QQYTF, QYTF (MIC < or = 12.5 microg/ml)...
  93. doi Severe musculoskeletal infection variant in Lemierre's syndrome
    Joshua D Harris
    Ohio State University Medical Center Department of Orthopedics, Division of Sports Medicine, Columbus, OH 43221 3502, USA joshua harris osumc edu
    Orthopedics 33:774. 2010
    Lemierre's syndrome is a severe complication of Fusobacterium necrophorum oropharyngeal infection associated with metastatic foci of infection, internal jugular vein thrombosis, and septicemia...
  94. ncbi Infection by Panton-Valentine leukocidin-producing Staphylococcus aureus clinically mimicking Lemierre's syndrome
    Girish H Shivashankar
    Erne Hospital, Enniskillen, Fermanagh BT74 6AY, UK
    J Med Microbiol 57:118-20. 2008
    ..It is usually caused by Fusobacterium necrophorum, a Gram-negative obligate anaerobe...
  95. doi Necrobacillosis in humans
    Gunnar Dahlen
    Department of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy at University of Gothenburg, PO Box 450, SE 405 30 Gothenburg, Sweden
    Expert Rev Anti Infect Ther 9:227-36. 2011
    ..in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seeded out in the ..
  96. ncbi Clinical, bacteriological, and histopathological study of toxic puerperal metritis in Iraqi buffalo
    O I Azawi
    Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
    J Dairy Sci 90:4654-60. 2007
    ..bacteria in uterine lumen were Escherichia coli, Arcanobacterium pyogenes, Staphylococcus aureus, and Fusobacterium necrophorum (18.5, 16.7, 13.0, and 9.3%, respectively)...
  97. ncbi Review of the in vitro activity of gemifloxacin against gram-positive and gram-negative anaerobic pathogens
    E J Goldstein
    R M Alden Research Laboratory, Santa Monica UCLA Medical Center, Santa Monica, CA 90494, USA
    J Antimicrob Chemother 45:55-65. 2000
    ..and fusobacteria (Fusobacterium nucleatum, Fusobacterium necrophorum) and moderate but variable potency against Gram-negative anaerobes...
  98. doi Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT
    Débora Heller
    Division of Graduate Periodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro RJ, Brazil
    J Clin Periodontol 38:355-64. 2011
    ..To compare the effects of systemic amoxicillin (AMX) plus metronidazole (MET) or placebos combined with anti-infective mechanical debridement on the sub-gingival microbiota of generalized aggressive periodontitis (GAP)...
  99. ncbi Some morphological, biochemical and immunological blood parameters in European bison with or without lesions in the digestive, respiratory, urinary and reproductive tracts
    K Anusz
    Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
    Pol J Vet Sci 10:137-42. 2007
    ..Bacillus spp., Fusobacterium necrophorum, Staphylococcus spp. (coagulase negative) and Staphylococcus hyicus)...
  100. doi Clinical spectrum of bacteraemic Fusobacterium infections: from septic shock to nosocomial bacteraemia
    Elina Nohrström
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
    Scand J Infect Dis 43:463-70. 2011
    ..Fusobacterium species are anaerobic bacteria that relatively rarely cause sepsis with a variable clinical presentation...
  101. doi Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum
    Masato Yoneda
    Division of Gastroenterology Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama Department of Pharmacology, Osaka University, Graduate School of Dentistry, Suita, Osaka, Japan
    Hepatol Res 41:194-6. 2011
    ..Here, we report a case of liver abscess associated with periodontal bacterial infection by Fusobacterium necrophorum, which is commonly found in the oropharyngeal flora...

Research Grants4

  1. CHARACTERIZATION OF VIRULENCE FACTORS OF F. NECROPHORUM
    HENRY BJORNSON; Fiscal Year: 1980
    ..To isolate and chemically characterize the hemolytic, leukocidal, and lethal factor or factors from Fusobacterium necrophorum K4 culture supernatants. 2. To determine if the hemolytic, leukocidal, and lethal factors in the F...
  2. Measuring Quality - The Impact of Patient Complexity
    Robert Centor; Fiscal Year: 2007
    ..Finally, we hope to present an economical research agenda to the research community and AHRQ at the national meeting. [unreadable] [unreadable] [unreadable]..
  3. Clinical Investigation in Pediatric Thrombosis
    Neil Goldenberg; Fiscal Year: 2007
    ..Additionally, translational studies will seek to identify novel candidate protein risk factors and prognostic markers for venous thrombosis in children. ..
  4. Clinical Investigation in Pediatric Thrombosis
    Neil Goldenberg; Fiscal Year: 2008
    ..Additionally, translational studies will seek to identify novel candidate protein risk factors and prognostic markers for venous thrombosis in children. ..