streptomyces

Summary

Summary: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.

Top Publications

  1. ncbi Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    S D Bentley
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 417:141-7. 2002
  2. pmc PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
    Bertolt Gust
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 100:1541-6. 2003
  3. doi The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
    Gilles P van Wezel
    Leiden University, Leiden Institute of Chemistry, Netherlands
    Nat Prod Rep 28:1311-33. 2011
  4. pmc The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways
    Marnix H Medema
    Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    Genome Biol Evol 2:212-24. 2010
  5. pmc Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    Yasuo Ohnishi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Bacteriol 190:4050-60. 2008
  6. pmc Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
    Luisa Laureti
    Unité Mixte de Recherche1128 Génétique et Microbiologie, Universite Henri Poincare, Institut Fédératif de Recherche 110 EFABA, F 54506 Vandœuvre lès Nancy, France
    Proc Natl Acad Sci U S A 108:6258-63. 2011
  7. pmc Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
    Mamoru Komatsu
    Laboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato University, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 107:2646-51. 2010
  8. pmc Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites
    Ju Yeon Song
    Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea
    J Bacteriol 192:6317-8. 2010
  9. doi Widespread homologous recombination within and between Streptomyces species
    James R Doroghazi
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    ISME J 4:1136-43. 2010
  10. doi Streptomyces as symbionts: an emerging and widespread theme?
    Ryan F Seipke
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK
    FEMS Microbiol Rev 36:862-76. 2012

Research Grants

Detail Information

Publications302 found, 100 shown here

  1. ncbi Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    S D Bentley
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 417:141-7. 2002
    b>Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine...
  2. pmc PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
    Bertolt Gust
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 100:1541-6. 2003
    Streptomycetes are high G+C Gram-positive, antibiotic-producing, mycelial soil bacteria. The 8.7-Mb Streptomyces coelicolor genome was previously sequenced by using an ordered library of Supercos-1 clones...
  3. doi The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
    Gilles P van Wezel
    Leiden University, Leiden Institute of Chemistry, Netherlands
    Nat Prod Rep 28:1311-33. 2011
    ..New technologies are also described that have potential to greatly further our understanding of gene regulation in what is an area fertile for discovery and exploitation..
  4. pmc The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways
    Marnix H Medema
    Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    Genome Biol Evol 2:212-24. 2010
    ..Genome sequencing of Streptomyces clavuligerus ATCC 27064, a Gram-positive soil bacterium known for its production of a diverse array of ..
  5. pmc Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    Yasuo Ohnishi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Bacteriol 190:4050-60. 2008
    We determined the complete genome sequence of Streptomyces griseus IFO 13350, a soil bacterium producing an antituberculosis agent, streptomycin, which is the first aminoglycoside antibiotic, discovered more than 60 years ago...
  6. pmc Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
    Luisa Laureti
    Unité Mixte de Recherche1128 Génétique et Microbiologie, Universite Henri Poincare, Institut Fédératif de Recherche 110 EFABA, F 54506 Vandœuvre lès Nancy, France
    Proc Natl Acad Sci U S A 108:6258-63. 2011
    ..Genome sequence analysis of Streptomyces ambofaciens ATCC23877 has revealed numerous secondary metabolite biosynthetic gene clusters, including a giant ..
  7. pmc Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
    Mamoru Komatsu
    Laboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato University, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 107:2646-51. 2010
    ..expression of genes encoding secondary metabolite biosynthesis, the genome of the industrial microorganism Streptomyces avermitilis was systematically deleted to remove nonessential genes. A region of more than 1...
  8. pmc Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites
    Ju Yeon Song
    Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea
    J Bacteriol 192:6317-8. 2010
    b>Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S...
  9. doi Widespread homologous recombination within and between Streptomyces species
    James R Doroghazi
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    ISME J 4:1136-43. 2010
    ..Intraspecies recombination was examined using strains of Streptomyces flavogriseus isolated from soils at five locations spanning 1000 km. The strains had >99...
  10. doi Streptomyces as symbionts: an emerging and widespread theme?
    Ryan F Seipke
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK
    FEMS Microbiol Rev 36:862-76. 2012
    b>Streptomyces bacteria are ubiquitous in soil, conferring the characteristic earthy smell, and they have an important ecological role in the turnover of organic material...
  11. ncbi The complex extracellular biology of Streptomyces
    Keith F Chater
    John Innes Centre, Norwich Research Park, Colney, Norwich, UK
    FEMS Microbiol Rev 34:171-98. 2010
    ..The rare codon TTA, which is present in the key pleiotropic regulatory gene adpA and many pathway-specific regulatory genes for antibiotic production, has a particular influence on extracellular biology...
  12. pmc SMC protein-dependent chromosome condensation during aerial hyphal development in Streptomyces
    Agnieszka Kois
    Faculty of Biotechnology, University of Wrocław, Tamka 2, 50 137 Wrocław, Poland
    J Bacteriol 191:310-9. 2009
    ..The conversion of multigenomic aerial hyphae of the mycelial organism Streptomyces coelicolor into chains of unigenomic spores requires the synchronous segregation of multiple chromosomes...
  13. pmc Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis
    Xiang Jing Wang
    School of Life Science, Northeast Agricultural University, Harbin, China
    J Bacteriol 192:4526-7. 2010
    b>Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins...
  14. doi Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
    Klas Flärdh
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Nat Rev Microbiol 7:36-49. 2009
    During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves ..
  15. pmc Linear Streptomyces plasmids form superhelical circles through interactions between their terminal proteins
    Hsiu Hui Tsai
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
    Nucleic Acids Res 39:2165-74. 2011
    Linear chromosomes and linear plasmids of Streptomyces possess covalently bound terminal proteins (TPs) at the 5' ends of their telomeres...
  16. doi Biodegradation of deltamethrin and its hydrolysis product 3-phenoxybenzaldehyde by a newly isolated Streptomyces aureus strain HP-S-01
    Shaohua Chen
    Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou, People s Republic of China
    Appl Microbiol Biotechnol 90:1471-83. 2011
    ..cultural, physio-biochemical characteristics, and 16S rDNA sequence analysis, strain HP-S-01 was identified as Streptomyces aureus...
  17. ncbi The ParB protein of Streptomyces coelicolor A3(2) recognizes a cluster of parS sequences within the origin-proximal region of the linear chromosome
    Dagmara Jakimowicz
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Mol Microbiol 45:1365-77. 2002
    The mycelial prokaryote Streptomyces coelicolor A3(2) possesses a large linear chromosome (8.67 Mb) with a centrally located origin of replication (oriC)...
  18. doi Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters
    Richard H Baltz
    CognoGen Biotechnology Consulting, 6438 North Olney Street, Indianapolis, IN 46220, USA
    J Ind Microbiol Biotechnol 37:759-72. 2010
    ..This review discusses the results of these studies, and the pros and cons of using various Streptomyces and one Saccharopolyspora strain for heterologous expression...
  19. ncbi The twin arginine protein transport pathway exports multiple virulence proteins in the plant pathogen Streptomyces scabies
    Madhumita V Joshi
    Department of Plant Pathology and Plant Microbe Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Microbiol 77:252-71. 2010
    Summary Streptomyces scabies is one of a group of organisms that causes the economically important disease potato scab. Analysis of the S...
  20. ncbi Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    Haruo Ikeda
    Kitasato Institute for Life Sciences, Kitasato University, Kanagawa 228 8555, Japan
    Nat Biotechnol 21:526-31. 2003
    Species of the genus Streptomyces are of major pharmaceutical interest because they synthesize a variety of bioactive secondary metabolites...
  21. pmc An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
    K Kaneda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 98:932-7. 2001
    A gene cluster encoding five enzymes of the mevalonate pathway had been cloned from Streptomyces sp. strain CL190...
  22. ncbi FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content
    J Ishikawa
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 174:251-3. 1999
    ..is a web-based tool for predicting protein-coding regions in bacterial DNA with a high G + C content, such as Streptomyces. The graphical output provides for easy distinction of protein-coding regions from non-coding regions...
  23. pmc Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights
    Yuki Goto
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS Biol 8:e1000339. 2010
    ..consist of three distinct catalytic domains and demonstrate in vitro enzyme activity of a family member from Streptomyces venezuelae...
  24. pmc Origin of the allyl group in FK506 biosynthesis
    Dusan Goranovic
    Acies Bio d o o, Tehnoloski Park 21, SI 1000 Ljubljana, Slovenia
    J Biol Chem 285:14292-300. 2010
    ..The entire gene cluster for biosynthesis of FK520 from Streptomyces hygroscopicus var. ascomyceticus has been cloned and sequenced...
  25. pmc Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase
    Wenjun Zhang
    Department of Chemical and Biomolecular Engineering, University of California Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095
    Appl Environ Microbiol 72:2573-80. 2006
    ..To this end, we have sequenced the gene cluster of oxytetracycline (oxy and otc genes) PKS genes from Streptomyces rimosus. Sequence analysis revealed a total of 21 genes between the otrA and otrB resistance genes...
  26. ncbi Effect of liquid culture requirements on antifungal antibiotic production by Streptomyces rimosus MY02
    Jicheng Yu
    Department of Bioengineering, Dalian Nationalities University, Dalian, PR China
    Bioresour Technol 99:2087-91. 2008
    b>Streptomyces rimosus MY02 was isolated from a soil sample which was collected from the northeast of China. The effect of medium components (i.e. carbon and nitrogen sources) and other culture requirements (i.e...
  27. ncbi The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
    K Wu
    Kosan Biosciences Inc, Hayward, CA 94545, USA
    Gene 251:81-90. 2000
    FK520 (ascomycin) is a macrolide produced by Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) that has immunosuppressive, neurotrophic and antifungal activities...
  28. doi Protein kinase inhibition of clinically important staurosporine analogues
    Osman A B S M Gani
    The Norwegian Structural Biology Center, Institute of Chemistry, University of Tromsø, 9037, Tromsø, Norway
    Nat Prod Rep 27:489-98. 2010
    ..Further, the mix of purely natural, biosynthetically and chemically modified compounds described here offer insights into prospects and strategies for drug discovery via bioprospecting...
  29. pmc Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues
    Sangjoon Mo
    Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120 750, Republic of Korea
    J Am Chem Soc 133:976-85. 2011
    ....
  30. pmc Characterization of Streptomyces padanus JAU4234, a producer of actinomycin X₂, fungichromin, and a new polyene macrolide antibiotic
    Zhi Qiang Xiong
    Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Appl Environ Microbiol 78:589-92. 2012
    Strain JAU4234, identified as Streptomyces padanus, was isolated from soil collected in Jiangxi Province, China. It produced actinomycin X2, fungichromin, and a new polyene macrolide compound with antifungal activity, antifungalmycin 702...
  31. pmc Genetics of Streptomyces rimosus, the oxytetracycline producer
    Hrvoje Petkovic
    Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Microbiol Mol Biol Rev 70:704-28. 2006
    From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics...
  32. pmc Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
    J Shima
    National Food Research Institute, Tsukuba, Ibaraki, Japan
    J Bacteriol 178:7276-84. 1996
    A strain of Streptomyces lividans, TK24, was found to produce a pigmented antibiotic, actinorhodin, although S. lividans normally does not produce this antibiotic...
  33. ncbi Streptomyces lunalinharesii sp. nov., a chitinolytic streptomycete isolated from cerrado soil in Brazil
    Rodrigo Fonseca de Souza
    Instituto de Microbiologia Prof Paulo de Goes, Universidade do Brasil, UFRJ, CCS, Bloco I, Ilha do Fundao, Rio de Janeiro, Brazil
    Int J Syst Evol Microbiol 58:2774-8. 2008
    ..actinomycete isolated from a Brazilian cerrado soil, designated strain RCQ1071(T), was assigned to the genus Streptomyces on the basis of chemical and morphological characteristics...
  34. doi Regulation of apical growth and hyphal branching in Streptomyces
    Klas Flärdh
    Department of Biology, Lund University, 223 62 Lund, Sweden
    Curr Opin Microbiol 15:737-43. 2012
    The filamentous bacteria Streptomyces grow by tip extension and through the initiation of new branches, and this apical growth is directed by a polarisome-like complex involving the essential polarity protein DivIVA...
  35. pmc Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae
    D J Wilson
    Department of Microbiology and Biological Process Technology Institute, University of Minnesota, 420 Delaware Street S.E, Minneapolis, MN 55455, USA
    J Bacteriol 183:3468-75. 2001
    The Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was analyzed, and its deduced product (PikD) was found to have amino acid sequence homology with a small family of bacterial regulatory proteins...
  36. pmc Novel pathway of salicylate degradation by Streptomyces sp. strain WA46
    Daisuke Ishiyama
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Appl Environ Microbiol 70:1297-306. 2004
    A novel salicylate-degrading Streptomyces sp...
  37. pmc Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems
    Dandan Chen
    Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
    Appl Environ Microbiol 78:5093-103. 2012
    ..In this study, we report the improvement of FK506 yield in the producing strain Streptomyces tsukubaensis by the duplication of two sets of pathway-specific genes individually encoding the biosyntheses of ..
  38. doi Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies
    David A Widdick
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
    Mol Microbiol 80:1395-412. 2011
    ..b>Streptomyces are unusual amongst Gram-positive bacteria because they export large numbers of lipoproteins via the twin ..
  39. doi Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32
    Hongbo Huang
    Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People s Republic of China
    J Nat Prod 75:202-8. 2012
    ..named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin...
  40. doi Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA
    Peng Fu
    Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China
    Org Lett 14:2422-5. 2012
    ..indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA...
  41. pmc A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus
    Ryan F Seipke
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
    PLoS ONE 6:e22028. 2011
    ..Actinobacterial species belonging to the genera Pseudonocardia, Streptomyces and Amycolatopsis have been isolated from attine ant nests and shown to confer protection against a range of ..
  42. doi Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
    Qunfei Zhao
    State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    Chem Biol 15:693-705. 2008
    ....
  43. doi Strain improvement in actinomycetes in the postgenomic era
    Richard H Baltz
    CognoGen Biotechnology Consulting, 6438 North Olney Street, Indianapolis, IN 46220, USA
    J Ind Microbiol Biotechnol 38:657-66. 2011
    ..An important observation that emerged from early Streptomyces genome sequencing projects was that each strain contains genes that encode 20 or more potential secondary ..
  44. pmc Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp
    Dong Chan Oh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Org Lett 11:633-6. 2009
    ..Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively...
  45. ncbi Coevolution of antibiotic production and counter-resistance in soil bacteria
    Paris Laskaris
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Environ Microbiol 12:783-96. 2010
    ..The distribution of the streptomycin (strA) and viomycin (vph) resistance genes was examined in Streptomyces isolates. strA and vph were found either within a biosynthetic gene cluster or independently...
  46. pmc Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus
    Bo Li
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:19731-5. 2010
    b>Streptomyces clavuligerus, an industrially important producer of clavulanate as well as cephem antibiotics, also produces the N-acylated dithiolopyrrolone antibiotic holomycin, a reported inhibitor of RNA synthesis...
  47. pmc Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes
    Javier Santos-Aberturas
    Institute of Biotechnology INBIOTEC, 24006 Leon, Spain
    J Biol Chem 286:9150-61. 2011
    Control of polyene macrolide production in Streptomyces natalensis is mediated by the transcriptional activator PimM...
  48. pmc Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp
    Dong Chan Oh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Org Lett 13:752-5. 2011
    ..unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium...
  49. doi Phenotypic variation in Streptomyces sp. DSM 40537, a lipoteichoic acid producing actinomycete
    O Rahman
    School of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK
    Lett Appl Microbiol 48:226-9. 2009
    To reinvestigate the production of lipoteichoic acid (LTA) by the actinomycete strain Streptomyces sp. DSM 40537 (=ATCC 3351).
  50. pmc Identification and characterization of a pSLA2 plasmid locus required for linear DNA replication and circular plasmid stable inheritance in Streptomyces lividans
    Zhongjun Qin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    J Bacteriol 185:6575-82. 2003
    b>Streptomyces linear plasmids and linear chromosomes can replicate also in a circular form when their telomeres are deleted. The 17-kb linear plasmid pSLA2 has been a useful model in studies of such replicons...
  51. pmc Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges
    Sheila Marie Pimentel-Elardo
    Julius von Sachs Institute for Biological Sciences, University of Wurzburg, Wurzburg, Germany
    Mar Drugs 8:373-80. 2010
    ..In this study, we report on the isolation of Streptomyces sp...
  52. pmc Identification of extracellular N-acylhomoserine lactone acylase from a Streptomyces sp. and its application to quorum quenching
    Sun Yang Park
    R and D Center, inBioNET Corporation, Daejeon 305 390, Korea
    Appl Environ Microbiol 71:2632-41. 2005
    ..In this study, strain M664, identified as a Streptomyces sp., was found to secrete an AHL-degrading enzyme into a culture medium...
  53. ncbi Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis
    Lily L Remsing
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, Kentucky 40536 0082, USA
    J Am Chem Soc 125:5745-53. 2003
    ..MTM), we focused on a post-polyketide synthase (post-PKS) tailoring step of the MTM biosynthesis by Streptomyces argillaceus ATCC 12956, which was proposed to be catalyzed by ketoreductase (KR) MtmW...
  54. pmc Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    R McDaniel
    Kosan Biosciences, Inc, 1450 Rollins Road, Burlingame, CA 94010, USA
    Proc Natl Acad Sci U S A 96:1846-51. 1999
    ..The manipulation of multiple biosynthetic steps in a PKS is an important milestone toward the goal of producing large libraries of unnatural natural products for biological and pharmaceutical applications...
  55. pmc Evidence that the extracytoplasmic function sigma factor sigmaE is required for normal cell wall structure in Streptomyces coelicolor A3(2)
    M S Paget
    John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    J Bacteriol 181:204-11. 1999
    The sigE gene of Streptomyces coelicolor A3(2) encodes an RNA polymerase sigma factor belonging to the extracytoplasmic function (ECF) subfamily...
  56. ncbi Mycobacterial linear plasmids have an invertron-like structure related to other linear replicons in actinomycetes
    M Picardeau
    Laboratoire de Référence des Mycobactéries, Institut Pasteur, Paris, France
    Microbiology 144:1981-8. 1998
    ..existed in the structure and terminal nucleotide sequence of pCLP and the termini of linear replicons of Streptomyces and Rhodococcus species, indicating a conservation of these linear extrachromosomal elements within the ..
  57. pmc Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production
    Amy Bishop
    School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Genome Res 14:893-900. 2004
    The model organism Streptomyces coelicolor represents a genus that produces a vast range of bioactive secondary metabolites. We describe a versatile procedure for systematic and comprehensive mutagenesis of the S. coelicolor genome...
  58. ncbi Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506
    H Motamedi
    Dept of Natural Products Drug Discovery, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Eur J Biochem 244:74-80. 1997
    The immunosuppressant FK506 is a 23-membered macrocyclic polyketide produced by several Streptomyces species. Sequencing of a 19.5-kb contiguous segment of DNA from the FK506 gene cluster of Streptomyces sp...
  59. ncbi PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi
    Rui Li
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Mol Microbiol 75:349-64. 2010
    polY, a transcriptional regulatory gene in the polyoxin biosynthetic cluster of Streptomyces cacaoi, was analysed, and its deduced product (PolY) showed amino acid sequence homology to AfsR from Streptomyces coelicolor A3(2)...
  60. doi Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring
    Johannes Kroiss
    Research Group Mass Spectrometry, Max Planck Institute for Chemical Ecology, Jena, Germany
    Nat Chem Biol 6:261-3. 2010
    Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens...
  61. ncbi Phenazine natural products: biosynthesis, synthetic analogues, and biological activity
    Jane Buus Laursen
    Department of Chemistry, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK 1871 Frederiksberg C, Denmark
    Chem Rev 104:1663-86. 2004
  62. pmc A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils
    Dennis Claessen
    Groningen Biomolecular Sciences and Biotechnology Institute GBB, Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Genes Dev 17:1714-26. 2003
    ..A class of eight hydrophobic secreted proteins, ChpA-H, was shown to be instrumental in the development of Streptomyces coelicolor...
  63. pmc The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor
    Marie A Elliot
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, UK
    Genes Dev 17:1727-40. 2003
    The filamentous bacterium Streptomyces coelicolor differentiates by forming specialized, spore-bearing aerial hyphae that grow into the air...
  64. ncbi Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2)
    Lautaro Diacovich
    Instituto de Biología Molecular y Celular de Rosario IBR Consejo Nacional de Investigaciones Científicas y Técnicas and Departamento de Microbiología, Universidad Nacional de Rosario, Suipaccha 531, 2000 Rosario, Argentina
    J Biol Chem 277:31228-36. 2002
    Two acyl-CoA carboxylases from Streptomyces coelicolor have been successfully reconstituted from their purified components. Both complexes shared the same biotinylated alpha subunit, AccA2...
  65. ncbi An engineered Streptomyces hygroscopicus aph 7" gene mediates dominant resistance against hygromycin B in Chlamydomonas reinhardtii
    Peter Berthold
    Lehrstuhl fur Genetik, Universitat Regensburg, NWFIII, Universitatsstrasse 31, D 93040 Regensburg, Germany
    Protist 153:401-12. 2002
    We have developed a positively selectable marker for the green alga Chlamydomonas reinhardtii using the Streptomyces hygroscopicus aminoglycoside phosphotransferase gene (aph7"). Its expression is controlled by C...
  66. pmc Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis
    Ying Zhuo
    Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
    Proc Natl Acad Sci U S A 107:11250-4. 2010
    Avermectin and its analogues are produced by the actinomycete Streptomyces avermitilis and are widely used in the field of animal health, agriculture, and human health...
  67. ncbi Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces
    Juan Francisco Martín
    Area de Microbiologia, Department of Molecular Biology, University of Leon, Leon, Spain
    Curr Opin Microbiol 13:263-73. 2010
    ..Two types of regulatory mechanisms have been studied in Streptomyces species: (1) pyramidal cascades of regulation that usually involve a butyrolactone and its receptor protein ..
  68. pmc Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans
    Haifeng Hu
    National Food Research Institute, Tsukuba, Ibaraki 305 8642, Japan
    J Bacteriol 184:3984-91. 2002
    ..activated by introducing certain mutations into the rpoB gene that confer resistance to rifampin to Streptomyces lividans 66, which produces less or no antibiotics under normal growth conditions...
  69. pmc Evolutionary relationships among diverse bacteriophages and prophages: all the world's a phage
    R W Hendrix
    Pittsburgh Bacteriophage Institute, Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 96:2192-7. 1999
    ..genetic connections, not always direct, among the lambdoid phages of Escherichia coli, phage phiC31 of Streptomyces, phages of Mycobacterium, a previously unrecognized cryptic prophage, phiflu, in the Haemophilus influenzae ..
  70. ncbi The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis
    Marta V Mendes
    Institute of Biotechnology INBIOTEC, Parque Cientifico de Leon, Av del Real no 1, 24006 Leon, Spain
    Metab Eng 9:217-27. 2007
    The biosynthesis of the antifungal pimaricin in Streptomyces natalensis is very sensitive to phosphate regulation. Concentrations of inorganic phosphate above 1mM drastically reduced pimaricin production...
  71. ncbi An efficient gene transfer system for the pimaricin producer Streptomyces natalensis
    Lorena L Enríquez
    Instituto de Biotecnologia INBIOTEC, Parque Cientifico de Leon, Leon, Spain
    FEMS Microbiol Lett 257:312-8. 2006
    b>Streptomyces natalensis produces the antifungal polyene macrolide pimaricin. Genetic manipulation of its biosynthetic genes has been hampered by the lack of efficient gene transfer systems...
  72. ncbi Co-production of caffeic acid and p-hydroxybenzoic acid from p-coumaric acid by Streptomyces caeruleus MTCC 6638
    Ashish Sachan
    Natural Product Biotechnology Group, Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, India
    Appl Microbiol Biotechnol 71:720-7. 2006
    In a culture medium of Streptomyces caeruleus MTCC 6638 grown with p-coumaric acid (5 mM) as the sole source of carbon, co-production of caffeic acid and p-hydroxybenzoic acid was observed...
  73. pmc Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination
    Lin Zhang
    Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Sci Rep 1:141. 2011
    ..The system was catalyzed by Streptomyces phage φBT1 integrase, which belongs to the large serine recombinase subfamily...
  74. doi Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor
    Sangjoon Mo
    Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea
    J Ind Microbiol Biotechnol 36:1473-82. 2009
    FK506 is a 23-membered polyketide macrolide with immunosuppressant activity produced by Streptomyces species. The production of FK506 in S...
  75. pmc Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A
    Linquan Bai
    Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China
    Chem Biol 13:387-97. 2006
    A 45 kb DNA sequencing analysis from Streptomyces hygroscopicus 5008 involved in validamycin A (VAL-A) biosynthesis revealed 16 structural genes, 2 regulatory genes, 5 genes related transport, transposition/integration or tellurium ..
  76. pmc Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis
    Lina Zheng
    Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e32033. 2012
    ..In the Val-A biosynthetic gene cluster in Streptomyces hygroscopicus 5008, the ORF valL was initially annotated as a validoxylamine A 7'-phosphate(V7P) synthase, ..
  77. ncbi Optimization of extracellular endoxylanase, endoglucanase and peroxidase production by Streptomyces sp. F2621 isolated in Turkey
    M Tuncer
    Biyoloji Bolumu, Fen Edebiyat Fakultesi, Mersin Universitesi, Ciftlikkoy, Mersin, Turkey
    J Appl Microbiol 97:783-91. 2004
    ..To determine the effect of environmental conditions on the production of extracellular lignocellulose-degrading enzymes by Streptomyces sp. F2621 and to assess the potential use of these enzymes in the hydrolysis of lignocellulose material.
  78. ncbi High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding
    Valerie Notenboom
    Protein Engineering Networks of Centres of Excellence and Department of Microbiology and Immunology and Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada
    Biochemistry 41:4246-54. 2002
    ..The C-terminal CBM, CBM13, of xylanase 10A from Streptomyces lividans is a family 13 CBM that is not only structurally similar to the "R-type" lectins but also somewhat ..
  79. pmc The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892
    Ute Galm
    Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, 777 Highland Ave, Madison, Wisconsin 53705, USA
    Mol Biosyst 5:77-90. 2009
    ..for the glycopeptide-derived antitumor antibiotic zorbamycin (ZBM) was cloned by screening a cosmid library of Streptomyces flavoviridis ATCC 21892. Sequence analysis revealed 40 ORFs belonging to the ZBM biosynthetic gene cluster...
  80. pmc Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis
    Lian Hua Xu
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 285:16844-53. 2010
    ..CYP105P1 and CYP105D6 from Streptomyces avermitilis, despite their high sequence similarities, catalyze filipin hydroxylation at different positions, ..
  81. doi Bioremediation of β-cypermethrin and 3-phenoxybenzaldehyde contaminated soils using Streptomyces aureus HP-S-01
    Shaohua Chen
    Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou, People s Republic of China
    Appl Microbiol Biotechnol 94:505-15. 2012
    Using laboratory and field experiments, the ability of Streptomyces aureus HP-S-01 to eliminate β-cypermethrin (β-CP) and its metabolite 3-phenoxybenzaldehyde (3-PBA) in soils was investigated. In the laboratory, 80.5% and 73...
  82. pmc DNA polymerase I is not required for replication of linear chromosomes in streptomyces
    Tzu Wen Huang
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
    J Bacteriol 190:755-8. 2008
    Both polA (encoding DNA polymerase I; Pol I) and a paralog were deleted from Streptomyces strains. Despite the UV sensitivity and slow growth caused by the DeltapolA mutation, the double mutant was viable...
  83. ncbi Studies on a new marine streptomycete BT-408 producing polyketide antibiotic SBR-22 effective against methicillin resistant Staphylococcus aureus
    P Sujatha
    Department of Biotechnology, Andhra University, Visakhapatnam 530003, India
    Microbiol Res 160:119-26. 2005
    ..against methicillin resistant Staphylococcus aureus has been characterized and found to be a novel strain of Streptomyces psammoticus...
  84. ncbi Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques
    Maria Carmody
    Department of Industrial Microbiology, Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Gene 343:107-15. 2004
    Amphotericin B is a medically important antifungal antibiotic that is produced by Streptomyces nodosus. Genetic manipulation of this organism has led to production of the first amphotericin analogues by engineered biosynthesis...
  85. ncbi Soil to genomics: the Streptomyces chromosome
    David A Hopwood
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich, NR4 7UH, United Kingdom
    Annu Rev Genet 40:1-23. 2006
    The 8-9-Mb Streptomyces chromosome is linear, with a "core" containing essential genes and "arms" carrying conditionally adaptive genes that can sustain large deletions in the laboratory...
  86. ncbi Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455
    S Zotchev
    UNIGEN Center for Molecular Biology and Department of Biotechnology, NTNU, Trondheim, Norway
    Microbiology 146:611-9. 2000
    b>Streptomyces noursei ATCC 11455 produces the antifungal polyene antibiotic nystatin containing the deoxysugar moiety mycosamine...
  87. ncbi Secretory production of recombinant proteins by Streptomyces
    Kristof Vrancken
    Rega Institute, Laboratory of Bacteriology, KU Leuven, Minderbroedersstraat 10, Leuven, B 3000, Belgium
    Future Microbiol 4:181-8. 2009
    ..origin, are currently only poorly secreted by this host, indicating the need for further optimization of Streptomyces as a production host...
  88. pmc Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis
    Jin Hee Lee
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 107:17557-62. 2010
    ..Interestingly, the enzyme has low substrate specificity and was used to methylate the clinical antibiotic fosfomycin and the antimalaria clinical candidate fosmidomycin, showing its promise for applications in bioengineering...
  89. doi SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN-sanO intergenic region in Streptomyces ansochromogenes
    Xihong He
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Microbiology 156:828-37. 2010
    b>Streptomyces ansochromogenes SanG is a pathway-specific regulator that mainly controls the transcription of two transcriptional units involved in nikkomycin biosynthesis...
  90. ncbi A putative two-component signal transduction system regulates sigmaE, a sigma factor required for normal cell wall integrity in Streptomyces coelicolor A3(2)
    M S Paget
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Mol Microbiol 33:97-107. 1999
    The extracytoplasmic function (ECF) sigma factor, sigmaE, is required for normal cell wall integrity in Streptomyces coelicolor...
  91. ncbi Genetic and physiological determinants of Streptomyces scabies pathogenicity
    Sylvain Lerat
    Centre SEVE, Departement de Biologie, Universite de Sherbrooke, Sherbrooke, QC, Canada, J1K 2R1
    Mol Plant Pathol 10:579-85. 2009
    ..It is caused by soil-borne filamentous bacteria belonging to the genus Streptomyces. Streptomycetes usually are saprophytic microorganisms, but a few species have acquired the ability to infect ..
  92. pmc Draft genome sequence of the marine Streptomyces sp. strain PP-C42, isolated from the Baltic Sea
    Longjiang Fan
    James D Watson Institute of Genome Sciences and Institute of Crop Science, Zhejiang University, Hangzhou 310029, China
    J Bacteriol 193:3691-2. 2011
    b>Streptomyces, a branch of aerobic Gram-positive bacteria, represents the largest genus of actinobacteria...
  93. ncbi Streptomyces sudanensis sp. nov., a new pathogen isolated from patients with actinomycetoma
    Erika T Quintana
    School of Biology, University of Newcastle, Newcastle upon Tyne, UK
    Antonie Van Leeuwenhoek 93:305-13. 2008
    Nine strains isolated from mycetoma patients and received as Streptomyces somaliensis were the subject of a polyphasic taxonomic study...
  94. doi Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway
    Miho Izumikawa
    Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2 4 7 Aomi, Koto ku, Tokyo 135 0064, Japan
    J Nat Prod 73:208-12. 2010
    ..As a result, Streptomyces sp. SpC080624SC-11 isolated from a marine sponge, Cinachyra sp...
  95. doi A bacterial glycosyltransferase gene toolbox: generation and applications
    Annette Erb
    Albert Ludwigs Universitat, Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie, Freiburg, Germany
    Phytochemistry 70:1812-21. 2009
    ..Investigations of the function, specificity and structure of these glycosyltransferases help to understand the great potential of these enzymes for natural product biosynthesis...
  96. ncbi Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Nicotiana tabacum
    W Wohlleben
    Lehrstuhl fur Genetik, Fakultat fur Biologie, Universitat Bielefeld, F R G
    Gene 70:25-37. 1988
    The phosphinothricin (Pt) N-acetyltransferase gene (pat) of Streptomyces viridochromogenes Tü494 is located on a 0.8-kb BglII fragment [Strauch et al., Gene 63 (1988) 65-74]. By sequencing a 1...
  97. ncbi Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel ins
    Lily L Remsing
    Department of Pharmaceutical Sciences, College of Pharmacy, Medical University of South Carolina, 280 Calhoun Street, P O Box 250140, Charleston, South Carolina 29425, USA
    J Am Chem Soc 124:1606-14. 2002
    Mithramycin is an aureolic acid-type antimicrobial and antitumor agent produced by Streptomyces argillaceus...
  98. ncbi The transglutaminase activating metalloprotease inhibitor from Streptomyces mobaraensis is a glutamine and lysine donor substrate of the intrinsic transglutaminase
    Susan Schmidt
    Department of Chemical Engineering and Biotechnology, University for Applied Sciences of Darmstadt, Schnittspahnstrasse 12, D 64287 Darmstadt, Germany
    FEBS Lett 582:3132-8. 2008
    Transglutaminase (TGase) from Streptomyces mobaraensis is an extra-cellular enzyme that cross-links proteins to high molecular weight aggregates...
  99. ncbi Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2)
    Ryo Natsume
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 8657, Tokyo, Japan
    J Mol Biol 336:409-19. 2004
    The gamma-butyrolactone-type autoregulator/receptor systems in the Gram-positive bacterial genus Streptomyces regulate morphological differentiation or antibiotic production, or both...
  100. ncbi The novel extracellular Streptomyces reticuli haem-binding protein HbpS influences the production of the catalase-peroxidase CpeB
    Darío Ortiz de Orué Lucana
    Universitat Osnabruck, FB Biologie Chemie, Barbarastrasse 11, D 49069 Osnabruck, Germany
    Microbiology 150:2575-85. 2004
    The Gram-positive soil bacterium and cellulose degrader Streptomyces reticuli synthesizes the mycelium-associated enzyme CpeB, which displays haem-dependent catalase and peroxidase activity, as well as haem-independent manganese-..
  101. ncbi Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces
    Bertolt Gust
    Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, Norwich, NR4 7UH, United Kingdom
    Adv Appl Microbiol 54:107-28. 2004

Research Grants76

  1. ENGINEERING PRECURSOR SUPPLY FOR POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2003
    ..Using the monensin producer Streptomyces cinnamononensis as a host the role of propionyl CoA carboxylase, crotonyl CoA reductase, isobutyryl CoA mutase, ..
  2. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 1999
    ..The applicants have found a novel compound, fostriecin, which has been purified from the fermentation broth of Streptomyces pulveraceus, and which has a pronounced cardioprotective effect in ischemic rabbit hearts...
  3. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2001
    ..The applicants have found a novel compound, fostriecin, which has been purified from the fermentation broth of Streptomyces pulveraceus, and which has a pronounced cardioprotective effect in ischemic rabbit hearts...
  4. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2002
    ..The applicants have found a novel compound, fostriecin, which has been purified from the fermentation broth of Streptomyces pulveraceus, and which has a pronounced cardioprotective effect in ischemic rabbit hearts...
  5. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2000
    ..The applicants have found a novel compound, fostriecin, which has been purified from the fermentation broth of Streptomyces pulveraceus, and which has a pronounced cardioprotective effect in ischemic rabbit hearts...
  6. Biosynthesis of Microbial Isoprenoids
    DAVID CANE; Fiscal Year: 2009
    ..such as the antibiotic pentalenolactone or the volatile organic geosmin, the odoriferous constituent of Streptomyces and of blue-green algae that is responsible for the characteristic earthy smell of freshly turned soil as well ..
  7. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2010
    ..such as the antibiotic pentalenolactone or the volatile organic geosmin, the odoriferous constituent of Streptomyces and of blue-green algae that is responsible for the characteristic earthy smell of freshly turned soil as well ..
  8. Characterization and Engineering of Fused Chorismate-Utilizing Enzymes
    WALTON BYRNES; Fiscal Year: 2009
    ..One such enzyme is from Streptomyces venezuelae (Sv), a chloramphenicol-producing Gram positive bacterium...
  9. Characterization and Engineering of Fused Chorismate-Utilizing Enzymes
    WALTON BYRNES; Fiscal Year: 2009
    ..One such enzyme is from Streptomyces venezuelae (Sv), a chloramphenicol-producing Gram positive bacterium...
  10. Characterization and Engineering of Fused Chorismate-Utilizing Enzymes
    WALTON MALCOLM BYRNES; Fiscal Year: 2010
    ..One such enzyme is from Streptomyces venezuelae (Sv), a chloramphenicol-producing Gram positive bacterium...
  11. BIOCHEMISTRY OF NATURAL PRODUCTS
    Pappachan Kolattukudy; Fiscal Year: 1990
    ..relevant enzymes from meibomian glands, harderian glands, uropygial glands, Mycobacterium tuberculosis bovis, Streptomyces erythreus, Euglena gracilis and Pisum sativum...
  12. Mechanistic X-Ray Crystallography of Mononuclear Iron Enzymes, TauD and HppE
    Danny Yun; Fiscal Year: 2007
    ..dioxygenase (TauD)from Escherichia coli and S-(2)-hydroxypropylphosphonic acid epoxidase (HppE)from Streptomyces wedmorensis...
  13. DOXORUBICIN BIOSYNTHESIS AND RESISTANCE
    Charles Hutchinson; Fiscal Year: 1999
    ..application proposes to investigate the genetic and biochemical regulation of doxorubicin (DXR) production in Streptomyces peucetius. DXR is an important cancer chemotherapy drug produced commercially by fermentation...
  14. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2007
    ..We have selected two enzymes, Streptomyces olivochromogenes xylose isomerase (Xyl) and Aeromonas proteolytica aminopeptidase (AAP), as primary model ..
  15. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    ..We have selected two enzymes, Streptomyces olivochromogenes xylose isomerase (Xyl) and Aeromonas proteolytica aminopeptidase (AAP), as primary model ..
  16. DOXORUBICIN BIOSYNTHESIS AND RESISTANCE
    CHARLES SIH; Fiscal Year: 2000
    ..application proposes to investigate the genetic and biochemical regulation of doxorubicin (DXR) production in Streptomyces peucetius. DXR is an important cancer chemotherapy drug produced commercially by fermentation...
  17. Dissecting the substrate specificity of acyl-CoA carboxylase
    Shiou Chuan Tsai; Fiscal Year: 2010
    ..toward our long-term goal, is to determine the molecular basis of substrate specificity of ACC and PCC from Streptomyces coelicolor. The S...
  18. Ecological triggers to exploit antibiotic and virulence factor regulation
    JASON MICHAEL CRAWFORD; Fiscal Year: 2012
    ..These Gram-negative Gammaproteobacteria rival Streptomyces, the most studied antibiotic producing genus, in terms of their secondary metabolic potential...
  19. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2001
    ..regulatory genes led to the isolation of the Mycobacterium smegmatis whmD gene which encodes a homologue of the Streptomyces coelicolor WhiB protein required for early sporulation control. Unlike its Streptomyces homologue, M...
  20. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
    ..regulatory genes led to the isolation of the Mycobacterium smegmatis whmD gene which encodes a homologue of the Streptomyces coelicolor WhiB protein required for early sporulation control. Unlike its Streptomyces homologue, M...
  21. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2002
    ..regulatory genes led to the isolation of the Mycobacterium smegmatis whmD gene which encodes a homologue of the Streptomyces coelicolor WhiB protein required for early sporulation control. Unlike its Streptomyces homologue, M...
  22. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2003
    ..regulatory genes led to the isolation of the Mycobacterium smegmatis whmD gene which encodes a homologue of the Streptomyces coelicolor WhiB protein required for early sporulation control. Unlike its Streptomyces homologue, M...
  23. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2004
    ..regulatory genes led to the isolation of the Mycobacterium smegmatis whmD gene which encodes a homologue of the Streptomyces coelicolor WhiB protein required for early sporulation control. Unlike its Streptomyces homologue, M...
  24. BIOSYNTHESIS OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 1992
    ..The first is the nucleoside antibiotic aristeromycin, a cyclopentyl analog of adenosine produced by Streptomyces citricolor and accompanied by the closely related antitumor and antiviral agent neplanocin A...
  25. BIOSYNTHESIS OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 1993
    ..The first is the nucleoside antibiotic aristeromycin, a cyclopentyl analog of adenosine produced by Streptomyces citricolor and accompanied by the closely related antitumor and antiviral agent neplanocin A...
  26. 2nd ASM Conference on Cell-Cell Communication
    Bonnie Bassler; Fiscal Year: 2004
    ..and Vibrio harveyi, the conjugal transfer system of Enterococcus faecatis, the production of antibiotics by Streptomyces spp., and the development of multicellular fruiting bodies of Myxococcus xanthus...
  27. PHASE I TRIAL OF FK317 IN PATIENTS WITH SOLID TUMORS
    George Wilding; Fiscal Year: 2000
    ..chemotherapeutic agents, Fujisawa Pharmaceuticals discovered a novel compound produced by an actinomycete, Streptomyces sandaensis, isolated from soil in Japan...
  28. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2004
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  29. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2005
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  30. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2003
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  31. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2005
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  32. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2002
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  33. Structural Basis for Bridged Bimetallic Enzyme Cataysis
    Dagmar Ringe; Fiscal Year: 2006
    ..We have selected two enzymes, Streptomyces olivochromogenes xylose isomerase (Xyl) and Aeromonas proteolytica aminopeptidase (AAP), as primary model ..
  34. CYCLOHEXANECARBOXYLIC ACID AND POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2006
    ..Combining five CHC-CoA biosynthetic genes from the ansatrienin biosynthesis gene cluster of Streptomyces collznus with the avermectin biosynthetic genes in an Streptomyces a vermitilis host, has resulted in an ..
  35. BIOSYNTHESIS AND METABOLISM OF NUCLEOSIDES
    Ronald Parry; Fiscal Year: 1993
    ..The first nucleoside whose biosynthesis will be investigated is sinefungin, which is produced by Streptomyces griseolus and S. incarnatus...
  36. ENGINEERING PRECURSOR SUPPLY FOR POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2000
    ..Using the monensin producer Streptomyces cinnamononensis as a host the role of propionyl CoA carboxylase, crotonyl CoA reductase, isobutyryl CoA mutase, ..
  37. ENGINEERING PRECURSOR SUPPLY FOR POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2002
    ..Using the monensin producer Streptomyces cinnamononensis as a host the role of propionyl CoA carboxylase, crotonyl CoA reductase, isobutyryl CoA mutase, ..
  38. ENGINEERING PRECURSOR SUPPLY FOR POLYKETIDE BIOSYNTHESIS
    Kevin Reynolds; Fiscal Year: 2001
    ..Using the monensin producer Streptomyces cinnamononensis as a host the role of propionyl CoA carboxylase, crotonyl CoA reductase, isobutyryl CoA mutase, ..
  39. Biosynthesis of hypermodified guanosines
    Valerie De Crecy Lagard; Fiscal Year: 2006
    ..a variety of natural products such as the antitumor antibiotics toyocamycin, sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  40. Biosynthesis of hypermodified gaunosines.
    Valerie De Crecy Lagard; Fiscal Year: 2009
    ..a variety of natural products such as the antitumor antibiotics toyocamycin,sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  41. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2005
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  42. ALTERNATIVE SIGMA FACTORS AND ANTIBIOTIC SYNTHESIS
    GEORGE JONES; Fiscal Year: 1999
    ..alternative sigma factor, sigmaE, in the regulation of actinomycin biosynthesis in the Gram-positive bacterium, Streptomyces antibioticus...
  43. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND JOSEPH BERGERON; Fiscal Year: 2010
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  44. Biosynthesis of hypermodified gaunosines.
    Valerie De Crecy Lagard; Fiscal Year: 2010
    ..a variety of natural products such as the antitumor antibiotics toyocamycin,sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  45. Biosynthesis of hypermodified guanosines
    Valerie De Crecy Lagard; Fiscal Year: 2007
    ..a variety of natural products such as the antitumor antibiotics toyocamycin, sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  46. Biosynthesis of hypermodified gaunosines.
    Valerie De Crecy Lagard; Fiscal Year: 2009
    ..a variety of natural products such as the antitumor antibiotics toyocamycin,sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  47. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2009
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  48. Biosynthesis of hypermodified gaunosines.
    Valerie De Crecy Lagard; Fiscal Year: 2007
    ..a variety of natural products such as the antitumor antibiotics toyocamycin,sangivamycin, and tubercidin from Streptomyces. The biosynthetic pathways to these deazapurines are poorly understood, a fact that has stymied functional ..
  49. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2006
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  50. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2007
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  51. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2005
    ..Desferrithiocin (DFT), a natural product iron chelator (siderophore) isolated from Streptomyces antibioticus, is one of the most orally effective iron chelating agents yet identified but renal toxicity ..
  52. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2005
    ..by applicant):Mithramycin (MTM) is an aureolic acid antimicrobial and antitumor agent produced by various Streptomyces species including S. argillaceus, which has been used, e.g., for the treatment of testicular carcinoma...
  53. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2004
    ..by applicant):Mithramycin (MTM) is an aureolic acid antimicrobial and antitumor agent produced by various Streptomyces species including S. argillaceus, which has been used, e.g., for the treatment of testicular carcinoma...
  54. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2002
    ..by applicant):Mithramycin (MTM) is an aureolic acid antimicrobial and antitumor agent produced by various Streptomyces species including S. argillaceus, which has been used, e.g., for the treatment of testicular carcinoma...
  55. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2001
    ..by applicant):Mithramycin (MTM) is an aureolic acid antimicrobial and antitumor agent produced by various Streptomyces species including S. argillaceus, which has been used, e.g., for the treatment of testicular carcinoma...
  56. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2002
    ..by applicant):Mithramycin (MTM) is an aureolic acid antimicrobial and antitumor agent produced by various Streptomyces species including S. argillaceus, which has been used, e.g., for the treatment of testicular carcinoma...
  57. DAUNORUBICIN DPSH GENE ON CYCLIZATION PATTERN FOR TYPE II POLYKETIDE SYNTHASE
    Charles Hutchinson; Fiscal Year: 2001
    Production of aklanoic acid, an early intermediate of daunorubicin (dnr) biosynthesis in Streptomyces peucetius, by hybrid type II polyletide synthase (PKS) genes was studied as a function of the order and type of genes cloned in a ..
  58. EXPLANATION OF WHY STREPTOMYCES PRODUCE ANTIBIOTICS
    JERALD ENSIGN; Fiscal Year: 1980
    ..The goal of this project is to define the role that antibodies play in the life cycle of the producing organisms. Streptomyces viridochromogenes excretes during spore germination an antibiotic which is also a germination inhibitor of ..
  59. DAUNORUBICIN DPSH GENE ON CYCLIZATION PATTERN FOR TYPE II POLYKETIDE SYNTHASE
    Charles Hutchinson; Fiscal Year: 2002
    Production of aklanoic acid, an early intermediate of daunorubicin (dnr) biosynthesis in Streptomyces peucetius, by hybrid type II polyletide synthase (PKS) genes was studied as a function of the order and type of genes cloned in a ..
  60. DAUNORUBICIN DPSH GENE ON CYCLIZATION PATTERN FOR TYPE II POLYKETIDE SYNTHASE
    Charles Hutchinson; Fiscal Year: 2000
    Production of aklanoic acid, an early intermediate of daunorubicin (dnr) biosynthesis in Streptomyces peucetius, by hybrid type II polyletide synthase (PKS) genes was studied as a function of the order and type of genes cloned in a ..
  61. DAUNORUBICIN DPSH GENE ON CYCLIZATION PATTERN FOR TYPE II POLYKETIDE SYNTHASE
    Charles Hutchinson; Fiscal Year: 1999
    Production of aklanoic acid, an early intermediate of daunorubicin (dnr) biosynthesis in Streptomyces peucetius, by hybrid type II polyletide synthase (PKS) genes was studied as a function of the order and type of genes cloned in a ..
  62. BIOSYNTHESIS OF MICROBIAL NATURAL PRODUCTS
    DAVID CANE; Fiscal Year: 1993
    ..2) The structural gene for the sesquiterpene cyclase, pentalenene synthase, a Streptomyces enzyme which catalyzes the cyclization of farnesyl diphosphate (8) to pentalenene (5), the parent hydrocarbon ..
  63. ASM Conference on Cell-Cell Communication in Bacteria
    STEPHEN WINANS; Fiscal Year: 2001
    ..and Vibrio harveyi, the conjugal transfer system of Enterococcus faecalis, the production of antibiotics by Streptomyces spp., and the development of multicellular fruiting bodies of Myxococcus xanthus...
  64. S. coelicolor P450s: Structure/Function/Engineering
    Michael Waterman; Fiscal Year: 2009
    b>Streptomyces coelicolor is the prototypic Streptomycete spp. Its physiological and genetic properties have been studied extensively...
  65. RAPAMYCIN ANALOGS FROM GENETICALLY ALTERED BACTERIA
    Leonard Katz; Fiscal Year: 1992
    ..of the proposed work is the biosynthesis of analogs of rapamycin in specifically constructed mutants of Streptomyces hygroscopicus ATCC 29253, the rapamycin producer...
  66. S. coelicolor P450s: Structure/Function/Engineering
    MICHAEL R contact WATERMAN; Fiscal Year: 2010
    b>Streptomyces coelicolor is the prototypic Streptomycete spp. Its physiological and genetic properties have been studied extensively...
  67. Regulation of Streptomyces differentiation and antibiotic production by SoxR
    Monica Chander; Fiscal Year: 2010
    ..examine the function and redox-sensing properties of SoxR in the evolutionarily divergent antibiotic producer Streptomyces coelicolor. S...
  68. Regulation of Streptomyces coelicolor Development-AREA
    AMY GEHRING; Fiscal Year: 2006
    ..of this application is to understand the molecular events that occur during development of the model bacterium Streptomyces coelicolor...
  69. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2007
    ..The goal of this project is to assess the utility of another such SSR, the integrase encoded by the Streptomyces bacteriophage phiC31, for manipulation of the zebrafish genome...