clostridium tetani

Summary

Summary: The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.

Top Publications

  1. ncbi Tetanus IgG antibody levels in children aged 12 to 47 months in Turkey
    R C Yildirim
    Kirikkale University Medical School, Public Health Department, Ankara, Turkey
    Am J Infect Control 29:120-3. 2001
  2. ncbi Current concepts in the management of Clostridium tetani infection
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 6:327-36. 2008
  3. ncbi BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani
    Stephanie Raffestin
    Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 25 28 rue du Dr Roux 75724, Paris Cedex 15, France
    Mol Microbiol 55:235-49. 2005
  4. pmc TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR
    J C Marvaud
    Unité des Toxines Microbiennes, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 66:5698-702. 1998
  5. ncbi Microbiologic characterization and antimicrobial susceptibility of Clostridium tetani isolated from wounds of patients with clinically diagnosed tetanus
    James I Campbell
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Am J Trop Med Hyg 80:827-31. 2009
  6. pmc Tetanus in injecting drug users, United Kingdom
    Susan J M Hahné
    Emerg Infect Dis 12:709-10. 2006
  7. pmc A decade of spore-forming bacterial infections among European injecting drug users: pronounced regional variation
    Vivian D Hope
    Health Protection Services, Health Protection Agency, London, UK
    Am J Public Health 102:122-5. 2012
  8. ncbi Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes
    Ruth E Soria-Guerra
    División de Biologia Molecular, IPICYT, Camino a la Presa San Jose 2055, 78216 San Luis Potosi, Mexico
    Plant Cell Rep 30:417-24. 2011
  9. ncbi Characterization of a heme oxygenase of Clostridium tetani and its possible role in oxygen tolerance
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Arch Microbiol 182:259-63. 2004
  10. pmc Immunization against Clostridium perfringens cells elicits protection against Clostridium tetani in mouse model: identification of cross-reactive proteins using proteomic methodologies
    Syed Imteyaz Alam
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, India
    BMC Microbiol 8:194. 2008

Detail Information

Publications160 found, 100 shown here

  1. ncbi Tetanus IgG antibody levels in children aged 12 to 47 months in Turkey
    R C Yildirim
    Kirikkale University Medical School, Public Health Department, Ankara, Turkey
    Am J Infect Control 29:120-3. 2001
    ..Further, it is a must in developing countries where vaccination efforts are hindered by cold-chain problems, underoptimum application practice, and high prevalence of concomitant infections...
  2. ncbi Current concepts in the management of Clostridium tetani infection
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 6:327-36. 2008
    ..Tetanus is an acute toxemic illness caused by Clostridium tetani infection at a laceration or break in the skin...
  3. ncbi BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani
    Stephanie Raffestin
    Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 25 28 rue du Dr Roux 75724, Paris Cedex 15, France
    Mol Microbiol 55:235-49. 2005
    Clostridium botulinum and Clostridium tetani, respectively, produce potent toxins, botulinum neurotoxin (BoNT) and tetanus neurotoxin (TeTx), which are responsible for severe diseases, botulism and tetanus...
  4. pmc TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR
    J C Marvaud
    Unité des Toxines Microbiennes, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 66:5698-702. 1998
    ..This supports that TetR positively regulates the TeTx gene in C. tetani and that a conserved mechanism of regulation of the neurotoxin genes is involved in C. tetani and C. botulinum...
  5. ncbi Microbiologic characterization and antimicrobial susceptibility of Clostridium tetani isolated from wounds of patients with clinically diagnosed tetanus
    James I Campbell
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Am J Trop Med Hyg 80:827-31. 2009
    b>Clostridium tetani is the etiologic agent of the muscle-spasming disease tetanus. Despite an effective vaccine, tetanus is an ongoing problem in some developing countries...
  6. pmc Tetanus in injecting drug users, United Kingdom
    Susan J M Hahné
    Emerg Infect Dis 12:709-10. 2006
  7. pmc A decade of spore-forming bacterial infections among European injecting drug users: pronounced regional variation
    Vivian D Hope
    Health Protection Services, Health Protection Agency, London, UK
    Am J Public Health 102:122-5. 2012
    ..Six countries reported 367 cases; rates varied from 0.03 to 7.54 per million people. Most cases (92%) were reported from 3 neighboring countries: Ireland, Norway, and the United Kingdom. This geographic variation needs investigation...
  8. ncbi Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes
    Ruth E Soria-Guerra
    División de Biologia Molecular, IPICYT, Camino a la Presa San Jose 2055, 78216 San Luis Potosi, Mexico
    Plant Cell Rep 30:417-24. 2011
    ..These findings support the concept of using transgenic tomatoes expressing sDPT polypeptide as model for edible vaccine against diphtheria, pertussis, and tetanus...
  9. ncbi Characterization of a heme oxygenase of Clostridium tetani and its possible role in oxygen tolerance
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Arch Microbiol 182:259-63. 2004
    In order to colonize mammalian wounds, the anaerobic bacterium Clostridium tetani must presumably cope with temporary oxic conditions...
  10. pmc Immunization against Clostridium perfringens cells elicits protection against Clostridium tetani in mouse model: identification of cross-reactive proteins using proteomic methodologies
    Syed Imteyaz Alam
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, India
    BMC Microbiol 8:194. 2008
    b>Clostridium tetani and Clostridium perfringens are among the medically important clostridial pathogens causing diseases in man and animals...
  11. ncbi Management and prevention of tetanus
    Richard F Edlich
    Plastic Surgical Research Program, University of Virginia Health System, Charlottesville, Virginia, USA
    J Long Term Eff Med Implants 13:139-54. 2003
    ..Because there is essentially no immunity to tetanus toxoid, the only effective way to control tetanus is by prophylactic immunization...
  12. ncbi Community-based seroepidemiology of tetanus in three selected provinces in Turkey
    Demet Kurtoglu
    Communicable Diseases Research Directorate, Refik Saydam National Hygiene Center, Ankara 06100, Turkey
    Jpn J Infect Dis 57:10-6. 2004
    ....
  13. pmc The genome sequence of Clostridium tetani, the causative agent of tetanus disease
    Holger Bruggemann
    Göttingen Genomics Laboratory and Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 100:1316-21. 2003
    ..The causative agent of tetanus disease is Clostridium tetani, an anaerobic spore-forming bacterium, whose natural habitat is soil, dust, and intestinal tracts of various ..
  14. ncbi Biochemical characterization of the catalytic domains of three different Clostridial collagenases
    Ulrich Eckhard
    Division of Structural Biology, Department of Molecular Biology, University of Salzburg, Billrothstrasse 11, A 5020 Salzburg, Austria
    Biol Chem 390:11-8. 2009
    ..These observations have consequences with respect to the topology of the N-terminus relative to the active site as well as possible activation mechanisms...
  15. ncbi Tetanus antitoxin levels among adults over 40 years of age in Central Anatolia, Turkey
    A Ozturk
    Erciyes Universitesi Tip, Fakültesi Halk Sagligi Anabilim Dali, Kayseri, Turkey
    Clin Microbiol Infect 9:33-8. 2003
    ..To determine tetanus antitoxin levels in adults and the aged...
  16. ncbi [Generalized tetanus in a teenager]
    F V Valla
    Service de Réanimation Pédiatrique, Hopital Debrousse, CHU de Lyon, 29 rue Soeur Bouvier, 69005 Lyon, France
    Arch Pediatr 14:362-4. 2007
    ..Tetanus has become an exceptional disease in industrialized countries since vaccination...
  17. ncbi Analysis of the case fatality rate of tetanus among adults in a tertiary hospital in Turkey
    O Ergonul
    Ankara Numune Training and Research Hospital, Infectious Diseases and Clinical Microbiology Clinic, Ankara, Turkey
    Eur J Clin Microbiol Infect Dis 22:188-90. 2003
    ..This suggests a need for adult vaccination programs and/or a plan to educate the public to recognize symptoms early and then rapidly seek medical care...
  18. ncbi Tetanus seroprevalence among farmers: a preliminary study
    Mary S Hayney
    Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison 53705, USA
    J Rural Health 19:109-12. 2003
    ..We hypothesized that tetanus antibody concentrations would be lower in farmers than in nonfarmers within the rural population...
  19. ncbi By the way, doctor. My doctor told me I'm overdue for a tetanus booster. I'm 60, and I wonder if it's really necessary at my age. Can't I just get one if I get a deep cut?
    Celeste Robb-Nicholson
    Harvard Medical School
    Harv Womens Health Watch 11:8. 2004
  20. ncbi Critical prevalence of antibodies minimizing vaccination costs for hepatitis A, hepatitis B, varicella, measles and tetanus in adults and adolescents in Catalonia, Spain
    Pedro Plans-Rubió
    Department of Health, General Direction of Public Health, Travessera de les Corts 131 159, 08028 Barcelona, Spain
    Vaccine 22:4002-13. 2004
    ..Vaccination strategies based on the critical prevalence of antibodies could maximize the immunity level in the community from available resources...
  21. ncbi Determination of tetanus antibodies by a double-antigen enzyme-linked immunosorbent assay in individuals of various age groups
    K Caglar
    Department of Medical Microbiology, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    Eur J Clin Microbiol Infect Dis 24:523-8. 2005
    ..Preventive measures against tetanus should therefore focus on scheduled booster immunization for adults as well as children...
  22. ncbi [Immunologic tests: Clostridium tetani]
    Motohide Takahashi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases
    Nihon Rinsho 63:206-9. 2005
  23. ncbi Immunity to tetanus of a rural population in a Greek county
    E Mendrinou
    Department of Microbiology, St Andrew Hospital
    New Microbiol 27:187-9. 2004
    ..In each sample, we estimated IgG antibodies against Clostridium tetani toxin. A protection level of 0.1 IU/ml was set. 15...
  24. ncbi Ulcerated rhabdomyosarcoma as portal of entry for tetanus in a previously nonimmunized child
    Vicente Odone-Filho
    Instituto de Tratamento do Câncer Infantil, Instituto da Criança, Departamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo, 05403 900 Sao Paulo, Brazil
    J Pediatr Hematol Oncol 27:227-8. 2005
    ..Due to an unfavorable evolution, the child underwent a hip disarticulation to provide tetanus control. The ulterior tumor management was successful: the child has been off therapy for more than 108 months with no evidence of disease...
  25. pmc Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments
    D Akbulut
    Food Safety Microbiology Laboratory, Health Protection Agency Centre for Infections, London, UK
    J Clin Microbiol 43:4342-8. 2005
    An upsurge in wound infections due to Clostridium botulinum and Clostridium tetani among users of illegal injected drugs (IDUs) occurred in the United Kingdom during 2003 and 2004...
  26. ncbi Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease
    Michael J Robinson
    Neonatal Department, Hope Hospital, Salford, United Kingdom
    Pediatrics 113:733-7. 2004
    ..To study the effect of dexamethasone in preterm infants with chronic lung disease (CLD) on antibody response to routine immunization against diphtheria, tetanus, and pertussis (DTP)...
  27. ncbi Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection
    Howard M Rosenblatt
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Allergy Clin Immunol 116:698-703. 2005
    ..HIV infection often impairs the immune response to childhood vaccines...
  28. ncbi Impaired immunity against tetanus in type 2 diabetes
    Ali Tamer
    Department of Internal Medicine, Izzet Baysal Medical School, Bolu, Turkey
    Med Sci Monit 11:CR580-4. 2005
    ..The aim of this study was to compare serum levels of tetanus antibody in diabetic patients over 50 years of age with those of age- and sex-matched non-diabetic controls...
  29. ncbi Protection against tetanus in the aged people in the Czech Republic--cross-sectional study
    Vladimir Janout
    Department of Preventive Medicine, Faculty of Medicine, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic
    Arch Gerontol Geriatr 40:123-8. 2005
    ....
  30. ncbi Tetanus complicating snakebite in northern Nigeria: clinical presentation and public health implications
    A G Habib
    Ahmadu Bello University Hospital, Zaria, Nigeria
    Acta Trop 85:87-91. 2003
    ..Snakebite is not uncommon and partly because of lack of effective antivenom, management in inaccessible areas could be complicated with tetanus in unimmunized victims...
  31. ncbi What is your diagnosis? Localised tetanus in a cat
    R M Baral
    Paddington Cat Hospital, 183 Glenmore Road, Paddington, NSW, 2021, Australia
    J Feline Med Surg 4:221-4. 2002
  32. ncbi The seroepidemiology of tetanus in Catalonia, Spain
    A Dominguez
    General Directorate of Public Health, Generalitat of Catalonia, Barcelona, Spain
    Med Microbiol Immunol 196:115-9. 2007
    ..9%) (P < 0.001). These results show that routine vaccination of children is successful. In adults aged > or = 45 years, the prevalence is inadequate and efforts should be made to increase vaccination...
  33. ncbi Coxofemoral luxation in a border collie as a complication of a Clostridium tetani infection
    M A Goldhammer
    Royal Dick School of Veterinary Studies, University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    J Small Anim Pract 49:159-62. 2008
    ..Coxofemoral luxation resulted as a complication of the tetanus and was successfully managed by performing a femoral head and neck excision. This is the first report of joint luxation associated with Clostridium tetani infection in a dog.
  34. ncbi Insufficient tetanus vaccination status in patients with chronic leg ulcers. Results of a prospective investigation in 100 patients
    A Korber
    Dermatology Clinic and Outpatient Clinic, University Duisburg Essen, Essen, Germany
    Dermatology 217:69-73. 2008
    Tetanus disease is caused by Clostridium tetani and is one of the most common infectious diseases worldwide...
  35. ncbi Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil
    K G Divino-Goes
    Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 40:1681-7. 2007
    ..8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood...
  36. ncbi Dysphagia in elderly women: consider tetanus
    A Rauch
    Clinic and Policlinic for Infectious Diseases, University Hospital, Inselspital, Bern, Switzerland
    Infection 34:35-8. 2006
    ..In Switzerland, the most recently reported tetanus cases occurred in elderly women with insufficient seroprotection...
  37. doi Video NeuroImage: Generalized tetanus in a 70-year-old woman
    G M De Marchis
    Ospedale Regionale di Locarno La Carità, 6600 Locarno, Switzerland
    Neurology 70:e70. 2008
  38. ncbi Antitetanus toxoid antibody titer of chronic hemodialysis patients in Iran
    Mohammad Mahdi Sagheb
    Department of Internal Medicine, Shiraz University of Medical Science, Shiraz, Iran
    Iran J Immunol 5:45-50. 2008
    ..Patients with end stage renal disease have higher incidence of infection diseases that is thought to be related to impaired immune system...
  39. pmc Protection against tetanus by needle-free inoculation of adenovirus-vectored nasal and epicutaneous vaccines
    Z Shi
    Vaxin, Inc, USA
    J Virol 75:11474-82. 2001
    ..Here we show that a protective immune response against live Clostridium tetani infection in mice can be elicited by an adenovirus vector encoding the tetanus toxin C fragment when ..
  40. ncbi The role of cell population kinetics in the efficacy of penicillin--an experimental analysis and stochastic modeling of the tumour tetanus and wound tetanus of the mouse
    U Schneeweiss
    Central Institute of Cancer Research, Academy of Sciences of the GDR
    Zentralbl Bakteriol Mikrobiol Hyg A 266:506-21. 1987
    ....
  41. ncbi Prevalence of tetanus immunity in the Egyptian population
    el Rashdy M Redwan
    Protein Research Department, GEBRI, Mubarak City for Scientific Research and Biotechnology Application, New Borg EL Arab, Alexandria, Egypt
    Hum Antibodies 11:55-9. 2002
    ..3% Significantly, more males (23.7%) unprotected against tetanus. Our results suggest that monitoring immunization status and administering the tetanus vaccine as required are essential to insure adequate and long-lasting antibody levels...
  42. ncbi [Tetanus immunity in the elderly in the Czech Republic]
    I Matouskova
    Epidemiol Mikrobiol Imunol 56:10-3. 2007
    ..The sporadic incidence of tetanus cases in the Czech Republic over the last 15 years indirectly indicates the efficacy of the immunization strategy used...
  43. ncbi Pharmacotherapy of tetanus--a review
    Venu Gopal Reddy
    Department of Anaesthesia and ICU, College of Medicine, Sultan Qaboos University, P O Box 35, PC 123 SQU, Muscat, Sultanate of Oman
    Middle East J Anaesthesiol 16:419-42. 2002
    With adequate immunization, tetanus caused by the gram-positive anaerobic cocci, clostridium tetani, is a preventable disease. In treating C...
  44. ncbi Neonatal tetanus--report of a case
    Milena Ilic
    Department of Epidemiology, University of Kragujevac Faculty of Medicine, Serbia
    Turk J Pediatr 52:404-8. 2010
    Neonatal tetanus is a severe, often fatal disease caused by the toxin Clostridium tetani. Neonatal tetanus is a generalized tetanus, which occurs in a neonate between 3-28 days of life...
  45. ncbi The genome BLASTatlas-a GeneWiz extension for visualization of whole-genome homology
    Peter F Hallin
    Center for Biological Sequence Analysis, Department of Systems Biology, The Technical University of Denmark, Lyngby, Denmark
    Mol Biosyst 4:363-71. 2008
    ..We provide examples of BLASTatlases, including the Clostridium tetani plasmid p88, where homologues for toxin genes can be easily visualized in other sequenced Clostridium ..
  46. pmc Cephalic tetanus from penetrating orbital wound
    Eloïse Guyennet
    Department of Ophthalmology, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, France
    Case Report Med 2009:548343. 2009
    Tetanus is a neurologic disorder caused by tetanospasmin, a protein toxin elaborated by Clostridium tetani. Cephalic tetanus is a localized form of the disease causing trismus and dysfunction of cranial nerves...
  47. ncbi Preliminary study of mucosal IgA in the equine small intestine: specific IgA in cases of acute grass sickness and controls
    F G Nunn
    Medical Microbiology, Centre for Infectious Diseases, University of Edinburgh College of Medicine and Veterinary Medicine, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UAE
    Equine Vet J 39:457-60. 2007
    ..Specific mucosal antibodies in the gastrointestinal (GI) tract are likely to be important in protection, and this study was performed to ascertain if such antibodies could be detected and if their levels were related to disease state...
  48. pmc Tetanus in a parenteral drug abuser: report of a case
    M P Francois
    Department of Medicine, Harlem Hospital Center, Columbia University College of Physicians and Surgeons, New York
    J Natl Med Assoc 86:223-5. 1994
    Tetanus is an infection caused by Clostridium tetani. In the United States, tetanus remains a significant problem primarily among nonimmunized or inadequately immunized individuals...
  49. ncbi Outbreak of necrotizing fasciitis due to Clostridium sordellii among black-tar heroin users
    Akiko C Kimura
    Division of Communicable Disease Control, California Department of Health Services, Gardena, California 90248, USA
    Clin Infect Dis 38:e87-91. 2004
    ..has resulted in an increased number of cases of wound botulism due to Clostridium botulinum, tetanus due to Clostridium tetani, and necrotizing soft-tissue infections due to a variety of clostridia...
  50. ncbi Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene
    Ruth Elena Soria-Guerra
    División de Biologia Molecular, Instituto Potosino de Investigacion Cientifica y Tecnologica, Camino a la Presa San Jose 2055, 78216 San Luis Potosi, S L P, Mexico
    Plant Cell Rep 26:961-8. 2007
    ..often fatal diseases due to the exotoxins produced by Corynebacterium diphteriae, Bordetella pertussis and Clostridium tetani. We are attempting to develop an edible DPT multicomponent vaccine in plants, based on the fusion of ..
  51. pmc Recently occurring adult tetanus in Korea: emphasis on immunization and awareness of tetanus
    Dong Hyeon Shin
    Department of Internal Medicine, Chonnam National University, Medical School, 8 Hak Dong, Dong Gu, Gwangju 501 757, Korea
    J Korean Med Sci 18:11-6. 2003
    ..the female who may have a lower immunity against tetanus, and the farmers who are likely to be exposed to Clostridium tetani. In addition, diagnosis of tetanus is often delayed in area where cases are seen infrequently...
  52. ncbi Phylogenetic positions of Clostridium chauvoei and Clostridium septicum based on 16S rRNA gene sequences
    P Kuhnert
    Institute of Veterinary Bacteriology, University of Bern, Switzerland
    Int J Syst Bacteriol 46:1174-6. 1996
    ..Bacteriol. 44:812-826, 1994), which includes Clostridium carnis, Clostridium perfringens, Clostridium botulinum, and Clostridium tetani. We found that 99.3% of the nucleotides in the genes of C. chauvoei and C. septicum are identical.
  53. ncbi Generation of plant-derived recombinant DTP subunit vaccine
    R Brodzik
    Biotechnology Foundation Laboratories at Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Vaccine 27:3730-4. 2009
    ..DTP) pediatric vaccine is produced from the corresponding pathogenic bacteria Corynebacterium diphtheriae, Clostridium tetani and Bordetella pertussis; five injected doses of DTaP (acellular) vaccine are required for every child in ..
  54. ncbi Comparative genomic analysis of a neurotoxigenic Clostridium species using partial genome sequence: Phylogenetic analysis of a few conserved proteins involved in cellular processes and metabolism
    Syed Imteyaz Alam
    Biotechnology Division, Defence Research and Development Establishment, Gwalior 474002, India
    Anaerobe 16:147-54. 2010
    ..b>Clostridium tetani produces tetanus neurotoxin and is responsible for the fatal tetanus disease...
  55. pmc Treatment principles in the management of open fractures
    William W Cross
    Department of Orthopaedic Surgery, University of Minnesota Medical School, 2450 Riverside Ave, Ste R 200, Minneapolis, MN 55454, USA
    Indian J Orthop 42:377-86. 2008
    ..All open fractures should be addressed for the risk of contamination from Clostridium tetani. When possible, early closure of open fracture wounds, either by primary means or by flaps, can also ..
  56. ncbi [Tetanus in the geriatric population: is it a collective health problem?]
    L M Pagliuca
    Universidade Federal do Ceara
    Rev Lat Am Enfermagem 9:69-75. 2001
    Tetanus is an infectious non-contagious disease caused by the bacillus Clostridium tetani, which penetrates in the organism through wounds...
  57. ncbi Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel sigma factor
    Bruno Dupuy
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Mol Microbiol 55:1196-206. 2005
    ..UviA is related to a special class of sigma factors found to date only in Clostridium species and responsible for activating transcription of toxin genes in Clostridium difficile, Clostridium tetani, and Clostridium botulinum.
  58. ncbi A case of clinical tetanus in a patient with protective antitetanus antibody level
    Alvaro Beltran
    South Med J 100:83. 2007
  59. ncbi Persistence of antibodies against tetanus upon revaccination
    I Matouskova
    Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Cent Eur J Public Health 13:99-102. 2005
    ..This finding together with a favorable epidemiological situation as regards the occurrence of tetanus could eventually enable to prolong the interval for revaccinating adults in the Czech Republic...
  60. ncbi [Inclusion of a rapid test in the current Health Ministry Guidelines with the purpose of improving anti-tetanus prophylaxis prescribed to wounded patients presenting at French Emergency Departments]
    D Elkharrat
    Service SAU adultes, Hopital Ambroise Pare, 9 avenue Charles de Gaulle, 92100 Boulogne Billancourt, France
    Med Mal Infect 35:323-8. 2005
  61. ncbi Phylogenomic analyses of clostridia and identification of novel protein signatures that are specific to the genus Clostridium sensu stricto (cluster I)
    Radhey S Gupta
    Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Int J Syst Evol Microbiol 59:285-94. 2009
    ..blastp searches on various proteins in the genomes of Clostridium tetani E88 and Clostridium perfringens SM101 have also identified more than 10 proteins that are found uniquely in ..
  62. ncbi A case of neonatal tetanus presented within 24 hours of life
    Sayan Chatterjee
    Medinipur Medical College and Hospital, Medinipur, West Bengal, India
    Trop Doct 43:43-5. 2013
    ..An ulcer gradually enlarged to 5 × 4 cm and a swab from ulcer showed Clostridium tetani (both on Gram staining and culture)...
  63. ncbi Tetanus prophylaxis for diabetic foot ulcers
    Lee C Rogers
    Saint Vincent Catholic Medical Centers, 152 11 89 th Avenue, New York, NY 11432, USA
    Clin Podiatr Med Surg 23:769-75, vii-i. 2006
    The infected or ulcerated diabetic foot is a suitable environment for Clostridium tetani. Tetanus intoxication as a result of foot ulcer has been described in the literature...
  64. ncbi [Immunoenzimatic detection of the Clostridium tetani bacterial toxin: an alternative to mice bioassays]
    Fernando Chaves
    Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Rev Biol Trop 54:253-6. 2006
    Cell-free extracts from 20 strains of Clostridium tetani isolated from soil samples, were tested for tetanus toxin production using an enzyme immunoassay...
  65. ncbi Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors
    Bruno Dupuy
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Mol Microbiol 60:1044-57. 2006
    The production of major extracellular toxins by pathogenic strains of Clostridium botulinum, Clostridium tetani and Clostridium difficile, and a bacteriocin by Clostridium perfringens is dependent on a related group of RNA polymerase ..
  66. ncbi Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen
    R M Thomas
    Intensive Care Unit, St James s University Hospital, Leeds, United Kingdom
    Anaesth Intensive Care 34:811-5. 2006
    ..The current strategies involved in treating tetanus are discussed...
  67. ncbi [Serological study carried out in Cambodia during a tetanus vaccination in adults]
    M Schlumberger
    Unit4 INSERM U618 protéases et vectorisation pulmonaires, Equipe vecteurs, virus et vaccins, Faculté de pharmacie Philippe Maupas, 31 avenue Gaspard Monge, 37200 Tours, France
    Bull Soc Pathol Exot 101:36-42. 2008
    ..Excluding vaccination in at-risk population for such a study would be however ethically unacceptable...
  68. ncbi Therapy and epidemiology of autism--clostridial spores as key elements
    Sydney M Finegold
    Infectious Diseases Section 111 F, VA Medical Center West Los Angeles, Los Angeles, CA 90073, United States
    Med Hypotheses 70:508-11. 2008
    ..These latter two hypotheses have major implications with regard to the epidemiology of this important and distressing disease and would encourage research into methods to eliminate clostridial spores from the home and other environments...
  69. ncbi An immunohistochemical study on a tetanus fatal case using toxin fragment C (TTC). Should it be a useful diagnostic tool?
    Emanuela Turillazzi
    Department of Forensic Pathology, University of Foggia, Italy
    Neuropathology 29:68-71. 2009
    ..Cultures from the wound were negative for Clostridium tetani; the CSF analysis was negative. On the 9th day after admission, the man died...
  70. pmc Molecular characterization of Clostridium tetani strains by pulsed-field gel electrophoresis and colony PCR
    Lucile Plourde-Owobi
    Research Department, Aventis Pasteur SA, Av Marcel Mérieux, Marcy L Etoile 69280, France
    Appl Environ Microbiol 71:5604-6. 2005
    Pulsed-field gel electrophoresis and PCR were applied for the first time to the molecular characterization of Clostridium tetani. Among five strains tested, one (CN1339) turned out to contain a mixture of two genetically different clones ..
  71. ncbi Immune responses of Asian elephants (Elephas maximus) to commercial tetanus toxoid vaccine
    William A Lindsay
    Ringling Bros and Barnum and Bailey Center for Elephant Conservation, 12850 Old Grade Road, Polk City, FL 33868, USA
    Vet Immunol Immunopathol 133:287-9. 2010
    ..Surprisingly older animals mounted a significantly higher response to revaccination than did younger animals...
  72. ncbi Post-traumatic endophthalmitis involving Clostridium tetani and Bacillus spp
    M N Iyer
    Department of Internal Medicine, The Christ Hospital, Cincinnati, Ohio 45219, USA
    Am J Ophthalmol 132:116-7. 2001
    PURPOSE: To report a case of post-traumatic infectious endophthalmitis caused by Clostridium tetani and Bacillus spp. METHODS: Case report...
  73. ncbi Influence of placental malaria infection and maternal hypergammaglobulinaemia on materno-foetal transfer of measles and tetanus antibodies in a rural west African population
    B J Okoko
    Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia, West Africa
    J Health Popul Nutr 19:59-65. 2001
    ..It is concluded that the combined influence of placental malaria infection and maternal hypergammaglobulinaemia is significantly associated with the transfer of impaired measles antibody in this population...
  74. ncbi Synthesis and antimicrobial activity of some new N-substituted quinoline derivatives of 1H-pyrazole
    Nilesh J Thumar
    Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India
    Arch Pharm (Weinheim) 344:91-101. 2011
    ..All the synthesized compounds were screened, against six bacterial pathogens, namely Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae, Salmonella typhi, Vibrio cholerae, Escherichia coli, and antifungal activity, ..
  75. ncbi Oncolysis by Clostridium oncolyticum M55 and subsequent enzymatic determination of sialic acid in serum
    E Marth
    Institute of Hygiene, University, Graz
    Zentralbl Bakteriol Mikrobiol Hyg A 265:33-44. 1987
    Since the discovery of the "Clostridium tetani phenomenon", various apathogenic clostridia have been used for tumour lysis. Experiments have been conducted to achieve a tumour diagnosis using radiolabelled antibodies to clostridia...
  76. ncbi Narrative review: tetanus-a health threat after natural disasters in developing countries
    Majid Afshar
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Ann Intern Med 154:329-35. 2011
    ..Collapsing structures and swirling debris inflict numerous crush injuries, fractures, and serious wounds. Clostridium tetani infects wounds contaminated with dirt, feces, or saliva and releases neurotoxins that may cause fatal ..
  77. pmc Tetanus: pathophysiology, treatment, and the possibility of using botulinum toxin against tetanus-induced rigidity and spasms
    Bjørnar Hassel
    Norwegian Defense Research Establishment, N 2027 Kjeller, Norway
    Toxins (Basel) 5:73-83. 2013
    Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem...
  78. ncbi Urocanate reductase: identification of a novel anaerobic respiratory pathway in Shewanella oneidensis MR-1
    Alexander V Bogachev
    Department of Molecular Energetics of Microorganisms, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
    Mol Microbiol 86:1452-63. 2012
    ..bacterial genera, such as Shewanella, Fusobacterium and Clostridium, the latter including the human pathogen Clostridium tetani. The UrdA activity in S...
  79. ncbi [Gene cloning, optimized expression and immunogenicity evaluation of tetanus toxin fragment C]
    Ming yong Wang
    Department of Immunology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:731-5. 2008
    ..To obtain highly purified tetanus toxin fragment C (TTC) with good immunogenicity...
  80. ncbi Antitetanus and antidiphtheria immunity in newborns
    S Durbaca
    Cantacuzino Institute, Bucharest, Romania
    Roum Arch Microbiol Immunol 58:267-72. 1999
    ....
  81. pmc Squeezing at entrance of proton transport pathway in proton-translocating pyrophosphatase upon substrate binding
    Yun Tzu Huang
    Department of Life Science and Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu 30013, Taiwan
    J Biol Chem 288:19312-20. 2013
    ..investigation single molecule FRET was employed to dissect the action at the pathway entrance in homodimeric Clostridium tetani H(+)-PPase upon ligand binding...
  82. ncbi Bacterial inhibition of phagocytosis
    J D Ernst
    San Francisco General Hospital, and Department of Medicine, University of California, 94143 0860, USA
    Cell Microbiol 2:379-86. 2000
    ..Clostridium species, for example, make a number of exotoxins of interest. Clostridium botulinum and Clostridium tetani neurotoxins inactivate the regulated secretory machinery by proteolytic cleavage of SNARE proteins, and ..
  83. ncbi Phage display of a human antibody against Clostridium tetani toxin
    G Esposito
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Pomezia Roma, Italy
    Gene 148:167-8. 1994
    ..The nucleotide sequence for the variable domain of both chains has been determined and compared to germline sequences...
  84. ncbi Differential antibody responses to Plasmodium falciparum-derived B-cell epitopes induced by diepitope multiple antigen peptides (MAP) containing different T-cell epitopes
    Nina Maria Vasconcelos
    Department of Immunology, Wenner Gren Institute, Stockholm University, SE 10691, Stockholm, Sweden
    Vaccine 23:343-52. 2004
    ..T-epitopes employed were from P. falciparum antigens (CS.T3, [T(*)]4 and EBP3) or from the Clostridium tetani toxin (P2)...
  85. pmc Clostridial neurotoxins
    A Goonetilleke
    Department of Neurology, Newcastle General Hospital, Regional Neurosciences Centre, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 75:iii35-9. 2004
  86. pmc Distance variations between active sites of H(+)-pyrophosphatase determined by fluorescence resonance energy transfer
    Yun Tzu Huang
    Department of Life Science and Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Hsin Chu 30013, Taiwan
    J Biol Chem 285:23655-64. 2010
    ..A working model is accordingly proposed elucidating the distance variations of dimeric H(+)-PPase upon substrate binding...
  87. ncbi Tetanus in pregnancy
    Jeanne S Sheffield
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Am J Perinatol 21:173-82. 2004
    ..It is caused by the release of two toxins produced by Clostridium tetani, a noninvasive gram-positive anaerobic bacillus...
  88. pmc Use of intrathecal and intravenous clonidine in a case of severe tetanus with acute renal failure
    Alok Kumar
    Senior Resident, Department of Anaesthesiology and Intensive Care Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110002, 3 B S A Hospital, Delhi
    Indian J Anaesth 53:204-8. 2009
    SUMMARY: Tetanus is an acute often fatal disease produced by the Gram-positive, obligate anaerobic bacterium Clostridium tetani. Prolonged intensive care is required in severe tetanus, with the associated complications including ..
  89. ncbi Clostridium novyi, sordellii, and tetani: mechanisms of disease
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan Health System, Ann Arbor, MI 48109, United States Department of Microbiology and Immunology, The University of Michigan Health System, Ann Arbor, MI 48109, United States Reproductive Sciences Program, The University of Michigan Health System, Ann Arbor, MI 48109, United States Electronic address
    Anaerobe 24:98-101. 2013
    ..A primary purpose of this manuscript is to provide a succinct review on the mechanisms of disease caused by intoxication by the pathogens Clostridium tetani, Clostridium novyi, and Clostridium sordellii.
  90. ncbi Display of heterologous antigens on the Bacillus subtilis spore coat using CotC as a fusion partner
    Emilia M F Mauriello
    Dipartimento di Fisiologia Generale ed Ambientale, Sezione di Microbiologia, Universita Federico II, Napoli, Italy
    Vaccine 22:1177-87. 2004
    ..Recombinant spores expressing tetanus toxin fragment C (TTFC) of Clostridium tetani or the B subunit of the heat-labile toxin of Escherichia coli (LTB) were used for oral dosing and shown to ..
  91. pmc Equivalent T cell epitope promiscuity in ecologically diverse human pathogens
    Kirsten E Wiens
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    PLoS ONE 8:e73124. 2013
    ..To address this question, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with distinct infection strategies and outcomes of human exposure...
  92. ncbi Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain
    Mutsuya Yamamoto
    Mitsubishi Pharma Corporation, Discovery Technology Laboratory, Yokohama, 227 0033, Japan
    J Neurosci 23:6759-67. 2003
    ..These transgenic mice will serve as an animal model to study the cerebellar function in motor coordination and learning...
  93. ncbi [Development studies of lyophilized standard diphtheria-tetanus-pertussis vaccines]
    Erkan Ozcengiz
    Mikrobiyol Bul 41:165-73. 2007
    ..It was concluded that the formulations prepared in this study can be used as standard vaccines after being calibrated against World Health Organization standards...
  94. ncbi Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells
    Junbao Yang
    Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
    J Clin Immunol 25:428-36. 2005
    ..the influenza A Puerto Rico/8/34 matrix protein (MP) derived peptide MP(41-60) VLMEWLKTRPILSPLTKGIL and the Clostridium tetani Tetanus Toxin (TT) derived peptide TT(634-653) DKISDVSTIVPYIGPALNIV were identified as the DP0401 restricted ..
  95. pmc Tetanus as cause of mass die-off of captive Japanese macaques, Japan, 2008
    Tomomi Nakano
    Azabu University, Kanagawa, Japan
    Emerg Infect Dis 18:1633-5. 2012
    In 2008 in Japan, 15/60 captive Japanese macaques died. Clostridium tetani was isolated from 1 monkey, and 11 had tetanus-specific symptoms. We conclude the outbreak resulted from severe environmental C. tetani contamination...
  96. pmc India is on the way forward to maternal and neonatal tetanus elimination!
    Mohan Bairwa
    PGIMS, Community Medicine, PGIMS, Medical Mod, Rohtak, Haryana 124001, India
    Hum Vaccin Immunother 8:1129-31. 2012
    Tetanus is an acute, potentially fatal disease, caused by a bacterium, Clostridium tetani. The disease usually occurs in newborns through infection of the unhealed umbilical stump, particularly when the stump is cut with a non-sterile ..
  97. ncbi [Tetanus prophylaxis after an injury; check the need for vaccination and immunoglobulin]
    Margreet J M Te Wierik
    GGD Midden Nederland, afd AGZ, Zeist
    Ned Tijdschr Geneeskd 157:A5906. 2013
    Tetanus can occur after an injury and is caused by the exotoxin of Clostridium tetani. Characteristics of generalised tetanus include spasms in the back and other muscles, trismus, risus sardonicus and difficulty in breathing caused by ..
  98. ncbi Serological survey of immunity to tetanus in adult population of Northern Halkidiki, Greece
    Nikolaos Symeonidis
    Paleohori Health Center, G M H Halkidiki, Thessaloniki, Greece
    Eur J Epidemiol 18:1147-52. 2003
    ..Because of the increased possibility of Clostridium tetani infection of the Northern Halkidiki population--like any other rural population the evaluation of the ..
  99. ncbi Evaluation of CP Chromo Select Agar for the enumeration of Clostridium perfringens from water
    Mammad Manafi
    The Institute for Hygiene and Applied Immunology, Medical University of Vienna, Austria Electronic address
    Int J Food Microbiol 167:92-5. 2013
    ..1%) were indole positive and were identified as Clostridium sordellii, Clostridium bifermentans or Clostridium tetani. Only 3 strains (0...
  100. ncbi Postoperative tetanus after laparoscopic obturator hernia repair for strangulated ileus: report of a case
    Mitsuo Mori
    Shirane Tokushukai Hospital, 2294 2 Nishino, Minami Alps, Yamanashi, 400 0213, Japan
    Surg Today 42:470-4. 2012
    ..b>Clostridium tetani organisms residing in the gastrointestinal tract were presumed to have been endogenously inoculated into the ..
  101. ncbi An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
    Narsidas J Parmar
    Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, District Anand, Gujarat, India
    Bioorg Med Chem Lett 22:3816-21. 2012
    ..antimicrobial activity studies it revealed all are active against Gram positive (Streptococcus pneumoniae, Clostridium tetani, and Bacillus subtilis), Gram negative (Salmonella typhi, Vibrio chlolerae and Escherichia coli), M...

Research Grants5

  1. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani. A thorough understanding of the CRISPR immunity has important implications in studies of bacterial pathogen ..
  2. GENE EXPRESSION DURING SPORULATION
    Patrick J Piggot; Fiscal Year: 2012
    ..anthracis, Clostridium tetani, C. perfringens, C. botulinum and C...
  3. Direct gas sensing and repellent response to toxic gases in anaerobic pathogens
    Charles W Hespen; Fiscal Year: 2013
    ..were identified through genomic analyses of the obligate anaerobic pathogens Clostridium botulinum and Clostridium tetani. Ubiquitous in biology, H-NOX domains are found in organisms from bacteria to mammals...
  4. NON-INVASIVE DELIVERY OF SKIN-TARGETED TETANUS VACCINES
    DE CHU TANG; Fiscal Year: 2002
    ..We have demonstrated that a protective immune response against live Clostridium tetani infection could be elicited in mice by a single topical application of a patch containing an adenovirus ..
  5. SPRINT- Randomized Trial of Tibial Fracture Fixation
    Marc Swiontkowski; Fiscal Year: 2006
    ..The large size of the trial will reveal a more reliable and precise estimate of the true effect of both treatments. The results from this trial will be useful in guiding clinical practice. ..