dictyostelium

Summary

Summary: A genus of protozoa, formerly also considered a fungus. Its natural habitat is decaying forest leaves, where it feeds on bacteria. D. discoideum is the best-known species and is widely used in biomedical research.

Top Publications

  1. pmc Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
    Stefan Pukatzki
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:1528-33. 2006
  2. pmc dictyBase update 2011: web 2.0 functionality and the initial steps towards a genome portal for the Amoebozoa
    Pascale Gaudet
    dictyBase, Northwestern University Biomedical Informatics Center and Center for Genetic Medicine, 420 E Superior St, Chicago, IL 60611, USA
    Nucleic Acids Res 39:D620-4. 2011
  3. pmc Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication
    Andrew J Heidel
    Leibniz Institute for Age Research Fritz Lipmann Institute, D 07745 Jena, Germany
    Genome Res 21:1882-91. 2011
  4. pmc Legionella eukaryotic-like type IV substrates interfere with organelle trafficking
    Karim Suwwan de Felipe
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University Medical Center, New York, New York, United States of America
    PLoS Pathog 4:e1000117. 2008
  5. doi Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
    Kristen F Swaney
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biophys 39:265-89. 2010
  6. pmc The ordered extension of pseudopodia by amoeboid cells in the absence of external cues
    Leonard Bosgraaf
    Department of Cell Biochemistry, University of Groningen, Haren, The Netherlands
    PLoS ONE 4:e5253. 2009
  7. pmc Conserved developmental transcriptomes in evolutionarily divergent species
    Anup Parikh
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genome Biol 11:R35. 2010
  8. pmc Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
    Richard Sucgang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genome Biol 12:R20. 2011
  9. pmc Transient localized patterns in noise-driven reaction-diffusion systems
    Inbal Hecht
    Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California 92093 0319, USA
    Phys Rev Lett 104:158301. 2010
  10. pmc Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid
    Xuehua Xu
    School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom
    Eukaryot Cell 6:899-906. 2007

Research Grants

Detail Information

Publications334 found, 100 shown here

  1. pmc Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
    Stefan Pukatzki
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:1528-33. 2006
    ..Using Dictyostelium discoideum as a model host, we have identified a virulence mechanism in a non-O1/non-O139 V...
  2. pmc dictyBase update 2011: web 2.0 functionality and the initial steps towards a genome portal for the Amoebozoa
    Pascale Gaudet
    dictyBase, Northwestern University Biomedical Informatics Center and Center for Genetic Medicine, 420 E Superior St, Chicago, IL 60611, USA
    Nucleic Acids Res 39:D620-4. 2011
    dictyBase (http://www.dictybase.org), the model organism database for Dictyostelium, aims to provide the broad biomedical research community with well integrated, high quality data and tools for Dictyostelium discoideum and related ..
  3. pmc Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication
    Andrew J Heidel
    Leibniz Institute for Age Research Fritz Lipmann Institute, D 07745 Jena, Germany
    Genome Res 21:1882-91. 2011
    b>Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas, a clade of altruistic multicellular organisms...
  4. pmc Legionella eukaryotic-like type IV substrates interfere with organelle trafficking
    Karim Suwwan de Felipe
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University Medical Center, New York, New York, United States of America
    PLoS Pathog 4:e1000117. 2008
    ..of many endosome-like structures containing undigested material when expressed in the protozoan host Dictyostelium discoideum...
  5. doi Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
    Kristen F Swaney
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biophys 39:265-89. 2010
    ..By exploiting the genetic advantages of Dictyostelium, investigators are working out the complex network of interactions between the proteins that have been ..
  6. pmc The ordered extension of pseudopodia by amoeboid cells in the absence of external cues
    Leonard Bosgraaf
    Department of Cell Biochemistry, University of Groningen, Haren, The Netherlands
    PLoS ONE 4:e5253. 2009
    ..movement by analyzing the direction, size and timing of approximately 2000 pseudopodia that are extended by Dictyostelium cells...
  7. pmc Conserved developmental transcriptomes in evolutionarily divergent species
    Anup Parikh
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genome Biol 11:R35. 2010
    ..The social amoebae Dictyostelium discoideum and Dictyostelium purpureum have similar developmental morphologies although their genomes are as ..
  8. pmc Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
    Richard Sucgang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genome Biol 12:R20. 2011
    ..There are four groups of dictyostelids, with the most derived being a group that contains the model species Dictyostelium discoideum.
  9. pmc Transient localized patterns in noise-driven reaction-diffusion systems
    Inbal Hecht
    Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California 92093 0319, USA
    Phys Rev Lett 104:158301. 2010
    ..Our work is motivated by a recent biological example showing transiently excited cell membrane regions...
  10. pmc Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid
    Xuehua Xu
    School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom
    Eukaryot Cell 6:899-906. 2007
    ..Using the social amoeba Dictyostelium discoideum, we show that an acute effect of VPA is the inhibition of chemotactic cell movement, a process ..
  11. pmc Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa
    Christopher T Price
    Department of Microbiology and Immunology, College of Medicine, University of Louisville, Kentucky, USA
    PLoS Pathog 5:e1000704. 2009
    ..rapid acquisition of polyubiquitinated proteins by the Legionella-containing vacuole (LCV) within macrophages, Dictyostelium discoideum, and Acanthamoeba...
  12. ncbi Chemotaxis in the absence of PIP3 gradients
    Oliver Hoeller
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 17:813-7. 2007
    Chemotaxing neutrophils and Dictyostelium amoebae produce in their plasma membranes the signaling lipid PI(3,4,5)P3 (PIP3) in gradients, which are orientated with the external chemotactic gradient and have been proposed to act as an ..
  13. pmc Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry
    Juan C Del Alamo
    Department of Mechanical and Aerospace Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:13343-8. 2007
    ..method and apply it to the analysis of the dynamics of the chemotactic migration of the amoeboid form of Dictyostelium discoideum...
  14. pmc External and internal constraints on eukaryotic chemotaxis
    Danny Fuller
    Cell and Developmental Biology, Division of Biological Sciences, Department of Physics, and Center for Theoretical Biological Physics, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:9656-9. 2010
    ..Here we determine the chemotactic response of Dictyostelium cells to exponential gradients of varying steepness and local concentration of the chemoattractant cAMP...
  15. ncbi Tumor suppressor PTEN mediates sensing of chemoattractant gradients
    Miho Iijima
    Department of Cell Biology, Johns Hopkins University, School of Medicine, 21205, Baltimore, MD, USA
    Cell 109:599-610. 2002
    ..Disruption of the PI 3-phosphatase, PTEN, in Dictyostelium discoideum dramatically prolonged and broadened the PH domain relocation and actin polymerization responses, ..
  16. pmc Persistent cell motion in the absence of external signals: a search strategy for eukaryotic cells
    Liang Li
    Department of Physics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 3:e2093. 2008
    ..cells have a search strategy when they are beyond the range of the signal they would otherwise move toward? Here we ask if single, isolated, Dictyostelium and Polysphondylium amoebae bias their motion in the absence of external cues.
  17. pmc Cells navigate with a local-excitation, global-inhibition-biased excitable network
    Yuan Xiong
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 107:17079-86. 2010
    ..Our study brings together heretofore diverse observations on spontaneous cytoskeletal activity, signaling responses to temporal stimuli, and spatial gradient sensing into a unified scheme...
  18. ncbi Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
    Natalie Andrew
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Nat Cell Biol 9:193-200. 2007
    ..multiple cell types are usually generated when existing ones bifurcate and are rarely made de novo; second, in Dictyostelium cells in shallow chemoattractant gradients, pseudopods are made at the same rate whether cells are moving up ..
  19. pmc Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts
    Monica Hagedorn
    Departement de Biochimie, Faculte des Sciences, Universite de Geneve, Sciences II, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Science 323:1729-33. 2009
    ..Using the social amoeba Dictyostelium as a genetically tractable host for pathogenic mycobacteria, we discovered that M. tuberculosis and M...
  20. ncbi Single-gene greenbeard effects in the social amoeba Dictyostelium discoideum
    David C Queller
    Department of Ecology and Evolution, MS 170, Rice University, Post Office Box 1892, Houston, TX 77251 1892, USA
    Science 299:105-6. 2003
    ..The csA gene in Dictyostelium discoideum acts as a single-gene greenbeard...
  21. pmc Dictyostelium finds new roles to model
    Jeffrey G Williams
    College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Genetics 185:717-26. 2010
    ..made using the model be of wider relevance? This review addresses these issues for the social amoeba Dictyostelium and highlights some of the organisms more recent applications...
  22. ncbi The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum
    Katrina Boeckeler
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Eur J Cell Biol 85:1047-57. 2006
    ..To investigate the molecular basis of this effect, we have used the biomedical model system Dictyostelium discoideum to dissect this signalling pathway...
  23. doi Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium
    Barbara Peracino
    Department of Clinical and Biological Sciences, University of Turin, AOU S Luigi, Reg Gonzole 10, 10043 Orbassano, Torino, Italy
    J Cell Sci 123:4039-51. 2010
    ..of PI3K, PTEN or PLC on Escherichia coli and Legionella pneumophila uptake by the professional phagocyte Dictyostelium discoideum. We show that L...
  24. ncbi Dictyostelium discoideum chemotaxis: threshold for directed motion
    Loling Song
    Laboratory of Atomic and Solid State Physics, Department of Physics, Cornell University, Ithaca, NY 14853, USA
    Eur J Cell Biol 85:981-9. 2006
    The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3',5'-monophosphate (cAMP) was studied using microfluidic devices...
  25. pmc Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes
    Jason King
    School of Biosciences, Cardiff University, Cardiff, UK
    PLoS ONE 5:e11151. 2010
    ..An alternative approach is to investigate the genetics of Li(+) sensitivity. Using the social amoeba Dictyostelium, we previously identified prolyl oligopeptidase (PO) as a modulator of Li(+) sensitivity...
  26. ncbi Adenylyl cyclase localization regulates streaming during chemotaxis
    Paul W Kriebel
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37 Room 1E24, Bethesda, MD 20892, USA
    Cell 112:549-60. 2003
    We studied the role of the adenylyl cyclase ACA in Dictyostelium discoideum chemotaxis and streaming. In this process, cells orient themselves in a head to tail fashion as they are migrating to form aggregates...
  27. ncbi An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    Satoshi Sawai
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 433:323-6. 2005
    Nutrient-deprived Dictyostelium amoebae aggregate to form a multicellular structure by chemotaxis, moving towards propagating waves of cyclic AMP that are relayed from cell to cell...
  28. pmc The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium
    Angelika A Noegel
    Center for Biochemistry, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    Mol Biol Cell 15:934-45. 2004
    ..We show that cell polarization, F-actin organization, and phototaxis are altered in a Dictyostelium CAP knockout mutant...
  29. pmc Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG
    Elisa Alvarez-Curto
    School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Biochem J 401:309-16. 2007
    ..crucial roles in controlling cell movement and gene regulation throughout development of the social amoeba Dictyostelium discoideum...
  30. pmc Vibrio cholerae requires the type VI secretion system virulence factor VasX to kill Dictyostelium discoideum
    Sarah T Miyata
    Department of Medical Microbiology and Immunology, 1 63 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Infect Immun 79:2941-9. 2011
    ..We present VasX as a novel virulence factor of the T6SS, as a V. cholerae mutant lacking vasX exhibits a phenotype of attenuated virulence toward Dictyostelium discoideum.
  31. doi Quantifying in vivo phosphoinositide turnover in chemotactically competent Dictyostelium cells
    Nadine Pawolleck
    Bourne Laboratory, Biomedical Sciences Division, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK
    Methods Mol Biol 571:283-90. 2009
    Phosphoinositide (PI) signalling is one of multiple signalling cascades involved in chemotaxis in Dictyostelium discoideum...
  32. doi Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila
    Sze Man Tung
    Zentrum für Biochemie, Universitat zu Koln, Germany
    Cell Microbiol 12:765-80. 2010
    Infection of Dictyostelium discoideum with Legionella pneumophila resulted in a large number of differentially regulated genes among them three core autophagy genes, ATG8, ATG9 and ATG16...
  33. doi Chemotaxis: finding the way forward with Dictyostelium
    Jason S King
    CRUK Beatson Institute, Bearsden, Glasgow, UK
    Trends Cell Biol 19:523-30. 2009
    ..This has led to the popularity of Dictyostelium discoideum, with its experimentally-friendly lifestyle and small, haploid genome, as a tool to dissect the ..
  34. ncbi Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum
    Grant P Otto
    Department of Anatomy and Cell Biology, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Mol Microbiol 51:63-72. 2004
    ..pneumophila infection requires macroautophagy. As L. pneumophila replicates in Dictyostelium discoideum, and macroautophagy genes have been identified and mutated in D...
  35. pmc Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the alpha-kinase domain
    Scott W Crawley
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 286:2607-16. 2011
    b>Dictyostelium discoideum myosin II heavy chain kinase A (MHCK A), a member of the atypical α-kinase family, phosphorylates sites in the myosin II tail that block filament assembly...
  36. pmc WASP family proteins: their evolution and its physiological implications
    Douwe M Veltman
    Beatson Institute for Cancer Research, Glasgow, United Kingdom
    Mol Biol Cell 21:2880-93. 2010
    ..An unusual Dictyostelium WASP homologue that has lost the WH1 domain has retained its function in clathrin-mediated endocytosis, ..
  37. ncbi Orientation of chemotactic cells and growth cones: models and mechanisms
    H Meinhardt
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35, D 72076 Tubingen, Germany
    J Cell Sci 112:2867-74. 1999
    ..Travelling waves or oscillations in counter phase can emerge on the cell cortex, in agreement with observations reported in the literature. In other ranges of parameters, the model accounts for the generation of a stable cell polarity...
  38. pmc Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells
    Lan Ma
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 87:3764-74. 2004
    Chemotaxing cells, such as Dictyostelium and mammalian neutrophils, sense shallow chemoattractant gradients and respond with highly polarized changes in cell morphology and motility...
  39. pmc Exploring the control circuit of cell migration by mathematical modeling
    Javier Satulovsky
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 94:3671-83. 2008
    ..we show that the mechanism of local stimulation global inhibition can readily account for the behavior of Dictyostelium under a large collection of conditions...
  40. pmc Navigation of chemotactic cells by parallel signaling to pseudopod persistence and orientation
    Leonard Bosgraaf
    Department of Cell Biochemistry, University of Groningen, Haren, The Netherlands
    PLoS ONE 4:e6842. 2009
    ..Here we use a new computational algorithm to analyze the extension of pseudopods by Dictyostelium cells...
  41. doi Collective cell migration in development
    Cornelis J Weijer
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Cell Sci 122:3215-23. 2009
    ....
  42. ncbi Towards a molecular understanding of human diseases using Dictyostelium discoideum
    Robin S B Williams
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK
    Trends Mol Med 12:415-24. 2006
    The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health...
  43. pmc Self-organization of the phosphatidylinositol lipids signaling system for random cell migration
    Yoshiyuki Arai
    Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:12399-404. 2010
    ..waves of PtdIns 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] are generated spontaneously on the membrane of Dictyostelium cells in the absence of a chemoattractant...
  44. pmc The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells
    Jason S King
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Dis Model Mech 2:306-12. 2009
    ..By using the genetically tractable organism Dictyostelium, we show that lithium suppresses PIP(3)-mediated signalling...
  45. ncbi The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
    L Kim
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 99:399-408. 1999
    ..Inhibition of GSK3 by 7-TM Wnt/wg receptor signaling is critical for specifying embryonic cell fate patterns. In Dictyostelium, the 7-TM cAMP receptors regulate GSK3 by parallel, antagonistic pathways to establish a developmental body ..
  46. pmc Ordered patterns of cell shape and orientational correlation during spontaneous cell migration
    Yusuke T Maeda
    Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 3:e3734. 2008
    ..Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using computational analyses...
  47. doi How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA
    Immunol Res 43:118-27. 2009
    ..Interestingly, a soil amoeba, Dictyostelium discoideum, uses these same behaviors to pursue and injest its bacterial food source and to organize its multi-..
  48. pmc Functional analysis of spontaneous cell movement under different physiological conditions
    Hiroaki Takagi
    Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    PLoS ONE 3:e2648. 2008
    ..For that purpose, we observed a series of spontaneous movements by Dictyostelium cells at different developmental periods by using a single cell tracking system...
  49. ncbi Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum
    Grant P Otto
    Department of Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:17636-45. 2003
    ..In Dictyostelium, development is induced by starvation, conditions under which autophagy is required for survival in yeast and ..
  50. doi An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis
    Nilgun Isik
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA
    Dev Cell 15:590-602. 2008
    ..We identified an Elmo-like protein, ElmoA, in Dictyostelium discoideum that unexpectedly functions as a negative regulator of actin polymerization...
  51. pmc Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases
    Hui Li
    Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, TX 78712, USA
    Eukaryot Cell 7:894-905. 2008
    ..We show that Dictyostelium discoideum contains a single Aurora kinase, DdAurora, that displays characteristics of both Aurora A and B...
  52. pmc Overlapping functions of the two talin homologues in Dictyostelium
    Masatsune Tsujioka
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 4, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8562, Japan
    Eukaryot Cell 7:906-16. 2008
    ..The cellular slime mold Dictyostelium discoideum has two talin homologues, talA and talB, and earlier studies have characterized the single knockout ..
  53. ncbi Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs
    D Dormann
    School of Life Sciences, Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    Development 128:4535-43. 2001
    Migration and behaviour of Dictyostelium slugs results from coordinated movement of its constituent cells. It has been proposed that cell movement is controlled by propagating waves of cAMP as during aggregation and in the mound...
  54. ncbi Regulation of PTEN by Rho small GTPases
    Zhong Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Cell Biol 7:399-404. 2005
    ..PTEN's intracellular localization and presumably activity are regulated by chemoattractants in Dictyostelium and mouse neutrophils. However, the mechanisms for its regulation remain elusive...
  55. ncbi Gene discovery in the Acanthamoeba castellanii genome
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Protist 156:203-14. 2005
    ..The data predict that A. castellanii exhibits a greater biosynthetic capacity than the free-living Dictyostelium discoideum and the parasite Entamoeba histolytica, providing an explanation for the ability of A...
  56. ncbi Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
    C Y Chung
    Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634, USA
    Mol Cell 7:937-47. 2001
    ..Addition of the PI3K inhibitor LY294002 results in a rapid loss of cell polarity and the axial distribution of actin, myosin, and PAKa. These results provide a mechanism by which PI3K regulates chemotaxis...
  57. pmc A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]
    Arjan Kortholt
    Department of Molecular Cell Biology, University of Groningen, 9751 NN Haren, The Netherlands
    Mol Biol Cell 21:936-45. 2010
    GbpD, a Dictyostelium discoideum guanine exchange factor specific for Rap1, has been implicated in adhesion, cell polarity, and chemotaxis...
  58. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    ..Moreover, the development of Dictyostelium is sensitive to lithium and to valproic acid, but resistance to both is conferred by deletion of the gene that ..
  59. doi Primitive agriculture in a social amoeba
    Debra A Brock
    Department of Ecology and Evolutionary Biology, Rice University, 6100 Main Street, Houston, Texas 77005, USA
    Nature 469:393-6. 2011
    ..Here we show that the social amoeba Dictyostelium discoideum has a primitive farming symbiosis that includes dispersal and prudent harvesting of the crop...
  60. pmc Automated characterization of cell shape changes during amoeboid motility by skeletonization
    Yuan Xiong
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Syst Biol 4:33. 2010
    ....
  61. pmc The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium
    Pishan Chang
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK
    Dis Model Mech 5:115-24. 2012
    ..work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of data to a mammalian synaptic release model...
  62. doi C-sequence of the Dictyostelium cytoplasmic dynein participates in processivity modulation
    Naoki Numata
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo, Japan
    FEBS Lett 585:1185-90. 2011
    We examined the functional roles of C-sequence, a 47-kDa non-AAA+ module at the C-terminal end of the 380-kDa Dictyostelium dynein motor domain...
  63. doi MidA is a putative methyltransferase that is required for mitochondrial complex I function
    Sergio Carilla-Latorre
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Cell Sci 123:1674-83. 2010
    b>Dictyostelium and human MidA are homologous proteins that belong to a family of proteins of unknown function called DUF185...
  64. ncbi The in vivo role of annexin VII (synexin): characterization of an annexin VII-deficient Dictyostelium mutant indicates an involvement in Ca(2+)-regulated processes
    V Doring
    Max Planck Institut fur Biochemie, Martinsried, FRG
    J Cell Sci 108:2065-76. 1995
    b>Dictyostelium discoideum cells harbor two annexin VII isoforms of 47 and 51 kDa which are present throughout development...
  65. doi Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium
    Xuehua Xu
    Chemotaxis Signal Section, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 3:ra71. 2010
    ..We suggest that chemoattractant receptors use a ligand-induced coupling rather than a precoupled mechanism to control the activation of G proteins during chemotaxis...
  66. pmc Use of a Dictyostelium model for isolation of genetic loci associated with phagocytosis and virulence in Klebsiella pneumoniae
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, 1, Sec 1, Jen Ai Rd, Taipei 10051, Taiwan
    Infect Immun 79:997-1006. 2011
    Phagocytosis resistance is an important virulence factor in Klebsiella pneumoniae. Dictyostelium has been used to study the interaction between phagocytes and bacteria because of its similarity to mammalian macrophages...
  67. ncbi Proteasomes from Dictyostelium discoideum: characterization of structure and function
    T M Schauer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    J Struct Biol 111:135-47. 1993
    We have isolated and purified 20 S proteasomes from Dictyostelium discoideum and characterized their proteolytic activities. Two-dimensional electrophoresis revealed 13 distinct spots...
  68. pmc SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods
    Douwe M Veltman
    Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 198:501-8. 2012
    ..We show that, unexpectedly, Dictyostelium discoideum SCAR knockouts could still spread, migrate, and chemotax using pseudopods driven by the Arp2/3 ..
  69. pmc Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis
    Hidekazu Kuwayama
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
    PLoS ONE 4:e6658. 2009
    In the early stages of development of the cellular slime mold Dictyostelium discoideum, chemotaxis toward cAMP plays a pivotal role in organizing discrete cells into a multicellular structure...
  70. pmc Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification
    Arjan Kortholt
    Department of Cell Biochemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands
    EMBO Rep 12:1273-9. 2011
    ..We used Dictyostelium mutants to investigate the minimal requirements for chemotaxis, and identified a basal signalling module ..
  71. pmc The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation
    Gene L Garcia
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 20:3295-304. 2009
    Starvation of Dictyostelium induces a developmental program in which cells form an aggregate that eventually differentiates into a multicellular structure...
  72. ncbi Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum
    D Warnecke
    Universitat Hamburg, Institut fur Allgemeine Botanik, 22609 Hamburg, Germany
    J Biol Chem 274:13048-59. 1999
    ..4.1.173). We cloned genes from three different yeasts and from Dictyostelium discoideum, the deduced amino acid sequences of which all showed similarities with plant sterol ..
  73. doi A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis
    Jianshe Yan
    Chemotaxis Signal Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Dev Cell 22:92-103. 2012
    ..Here, we identified a Gβγ effector, ElmoE in Dictyostelium, and demonstrated that it is required for GPCR-mediated chemotaxis...
  74. pmc A role for tRNA(His) guanylyltransferase (Thg1)-like proteins from Dictyostelium discoideum in mitochondrial 5'-tRNA editing
    Maria G Abad
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    RNA 17:613-23. 2011
    ..Here we investigate the activities of four Thg1-like proteins (TLPs) encoded by the genome of the slime mold, Dictyostelium discoideum (a member of the eukaryotic supergroup Amoebozoa)...
  75. ncbi Formation of Hirano bodies in Dictyostelium and mammalian cells induced by expression of a modified form of an actin-crosslinking protein
    Andrew G Maselli
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Cell Sci 115:1939-49. 2002
    ..activated actin binding and calcium-insensitive actin filament crosslinking activity were expressed in Dictyostelium and mammalian cells to assess the behavior of these modified forms in vivo...
  76. ncbi Functional plasticity of CH domains
    Mario Gimona
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    FEBS Lett 513:98-106. 2002
    ....
  77. pmc Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium
    Nicole Terbach
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW200EX, UK
    J Cell Sci 124:2267-76. 2011
    ..of cellular, molecular and genetic approaches to characterize VPA uptake using a simple biomedical model, Dictyostelium discoideum. We show that VPA is taken up against an electrochemical gradient in a dose-dependent manner...
  78. pmc Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum
    Xiao Yin Zhang
    Medical Research Council, Laboratory for Molecular Biology, Cambridge, United Kingdom
    PLoS Genet 5:e1000645. 2009
    Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents...
  79. doi Molecular dynamics and forces of a motile cell simultaneously visualized by TIRF and force microscopies
    Yoshiaki Iwadate
    Department of Functional Molecular Biology, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Biotechniques 44:739-50. 2008
    ..detection of the spatiotemporal distribution of traction forces produced by individual filopodia in migrating Dictyostelium cells, as well as simultaneous visualization of these traction forces and the dynamics of filamentous myosin II...
  80. doi Changing directions in the study of chemotaxis
    Robert R Kay
    MRC Laboratory of Molecular Biology, Hill Road, Cambridge CB2 0QH, UK
    Nat Rev Mol Cell Biol 9:455-63. 2008
    ....
  81. pmc Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells
    Masamitsu Kanada
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Mol Biol Cell 16:3865-72. 2005
    ..Nonetheless, myosin II-null cells of the cellular slime mold Dictyostelium divide efficiently when adhering to substrates by making use of polar traction forces...
  82. ncbi Myosin II-independent cytokinesis in Dictyostelium: its mechanism and implications
    T Q Uyeda
    Biomolecular Research Group, National Institute for Advanced Interdisciplinary Research, Tsukuba, Ibaraki, Japan
    Cell Struct Funct 25:1-10. 2000
    Similar to higher animal cells, ameba cells of the cellular slime mold Dictyostelium discoideum form contractile rings containing filaments of myosin II during mitosis, and it is generally believed that contraction of these rings bisects ..
  83. pmc The role of cell contraction and adhesion in dictyostelium motility
    Mathias Buenemann
    Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California, USA
    Biophys J 99:50-8. 2010
    The crawling motion of Dictyostelium discoideum on substrata involves a number of coordinated events including cell contractions and cell protrusions...
  84. ncbi Glycogen synthase kinase 3 regulates cell fate in Dictyostelium
    A J Harwood
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
    Cell 80:139-48. 1995
    Extracellular cyclic AMP (cAMP) induces the formation of prespore cells in Dictyostelium but inhibits stalk cell formation...
  85. pmc Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling
    Paul B Bokko
    Department of Microbiology, La Trobe University, Melbourne, Victoria 3086, Australia
    Mol Biol Cell 18:1874-86. 2007
    ..a pharmacological AMPK activator in mammalian cells, mimics mitochondrial disease in impairing Dictyostelium phototaxis and that AMPKalpha antisense-inhibited cells were resistant to this effect...
  86. ncbi Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice
    Leung Kim
    Laboratory of Cellular and Developmental Biology, Building 50 3351, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 3:523-32. 2002
    Asymmetric body axis formation is central to metazoan development. Dictyostelium establishes an anterior/posterior axis utilizing seven-transmembrane cAMP morphogen receptors (CARs) and GSK3-mediated signal transductions that has a ..
  87. ncbi Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
    Ulrike Dürrwang
    Abteilung Biophysik, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    J Cell Sci 119:550-8. 2006
    ..A complete analysis of the kinetic and motor properties of Dictyostelium discoideum myosin-IE was achieved by the use of motor domain constructs with artificial lever arms...
  88. pmc Cell speed, persistence and information transmission during signal relay and collective migration
    Colin P McCann
    Department of Physics, University of Maryland College Park, College Park, MD 20742 4111, USA
    J Cell Sci 123:1724-31. 2010
    Collective migration is a key feature of the social amoebae Dictyostelium discoideum, where the binding of chemoattractants leads to the production and secretion of additional chemoattractant and the relay of the signal to neighboring ..
  89. pmc Directional sensing in eukaryotic chemotaxis: a balanced inactivation model
    Herbert Levine
    Center for Theoretical Biological Physics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:9761-6. 2006
    Many eukaryotic cells, including Dictyostelium discoideum amoebae, fibroblasts, and neutrophils, are able to respond to chemoattractant gradients with high sensitivity...
  90. pmc Myosin II is essential for the spatiotemporal organization of traction forces during cell motility
    Ruedi Meili
    Section of Cell and Developmental Biology, Division of Biological Sciences, Department of Mechanical and Aerospace Engineering, and Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 21:405-17. 2010
    ..However, it does not reduce significantly the magnitude of the traction forces, uncovering a non-MyoII-mediated mechanism for the contractility of the cell...
  91. pmc General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se
    Yan Zhang
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:3393-405. 2010
    ..examples of increased utilization of proteins that use copper in land plants, cobalt in Dehalococcoides and Dictyostelium, and selenium in fish and algae, whereas nematodes were found to have great diversity of copper transporters...
  92. pmc Transcriptional regulation of Dictyostelium pattern formation
    Jeffrey G Williams
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO Rep 7:694-8. 2006
    On starvation, Dictyostelium cells form a terminally differentiated structure, known as the fruiting body, which comprises stalk and spore cells...
  93. ncbi Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches
    Marten Postma
    Department of Biochemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Cell Sci 117:2925-35. 2004
    The leading edge of Dictyostelium cells in chemoattractant gradients can be visualized using green fluorescent protein (GFP) tagged to the pleckstrin-homology (PH) domain of cytosolic regulator of adenylyl cyclase (CRAC), which ..
  94. pmc Chemotaxis, chemokine receptors and human disease
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Cytokine 44:1-8. 2008
    ..In this review, we wish to mention landmark discoveries in the chemotaxis research field that shaped our current understanding of this fundamental cell behavior and lay out key questions that remain to be addressed in the future...
  95. pmc Functional characterization of intracellular Dictyostelium discoideum P2X receptors
    Melanie J Ludlow
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 284:35227-39. 2009
    ..ion channel activation, extracellular ATP evokes a rapid and transient calcium influx in the model eukaryote Dictyostelium discoideum. Five P2X-like proteins (dP2XA-E) are present in this organism...
  96. doi Dictyostelium discoideum--a model for many reasons
    Sarah J Annesley
    Department of Microbiology, La Trobe University, Bundoora, VIC 3086, Australia
    Mol Cell Biochem 329:73-91. 2009
    The social amoeba or cellular slime mould Dictyostelium discoideum is a "professional" phagocyte that has long been recognized for its value as a biomedical model organism, particularly in studying the actomyosin cytoskeleton and ..
  97. doi Eat, kill or die: when amoeba meets bacteria
    Pierre Cosson
    University of Geneva, Faculty of Medicine, Centre Medical Universitaire, Dpt de Physiologie Cellulaire et Métabolisme, 1 rue Michel Servet, CH1211 Geneva 4, Switzerland
    Curr Opin Microbiol 11:271-6. 2008
    ..b>Dictyostelium discoideum is by far the most studied amoeba, and it is proving useful to analyze phagocytosis and ..
  98. pmc Dictyostelium discoideum as a model system for identification of Burkholderia pseudomallei virulence factors
    Benjamin M Hasselbring
    Department of Microbiology, 210 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
    Infect Immun 79:2079-88. 2011
    ..the closely related nearly avirulent species Burkholderia thailandensis to predation by the phagocytic amoeba Dictyostelium discoideum...
  99. ncbi A coat of filamentous actin prevents clustering of late-endosomal vacuoles in vivo
    Anja Drengk
    Abteilung Zellbiologie and Center for Interdisciplinary Nanostructure Science and Technology CINSaT, Universitat Kassel, Heinrich Plett Str 40, 34132, Kassel, Germany
    Curr Biol 13:1814-9. 2003
    ..Here, we investigate the function of the actin coat that surrounds late endosomes in Dictyostelium. Latrunculin treatment leads to aggregation of these endosomes into grape-like clusters and completely blocks ..
  100. ncbi Infection in a dish: high-throughput analyses of bacterial pathogenesis
    C Leopold Kurz
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Curr Opin Microbiol 10:10-6. 2007
    Diverse aspects of host-pathogen interactions have been studied using non-mammalian hosts such as Dictyostelium discoideum, Caenorhabditis elegans, Drosophila melanogaster and Danio rerio for more than 20 years...
  101. ncbi Cross-induction of cell types in Dictyostelium: evidence that DIF-1 is made by prespore cells
    R R Kay
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:4959-66. 2001
    To investigate how cell type proportions are regulated during Dictyostelium development, we have attempted to find out which cell type produces DIF-1, a diffusible signal molecule inducing the differentiation of prestalk-O cells...

Research Grants88

  1. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    ..We are using the simple amoeba Dictyostelium discoideum as a model system for identifying signaling pathways that regulate myosin assembly...
  2. Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    Diane L Barber; Fiscal Year: 2010
    ..We showed a leading-edge H+ efflux by NHE1 in mammalian fibroblasts and in Dictyostelium cells is necessary for three stages in cell migration: polarity, actin filament assembly driving membrane ..
  3. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS contact LASHERAS; Fiscal Year: 2010
    ..b>Dictyostelium discoideum has proven to be an excellent model for the chemotactic migration of amoeboid cells such as ..
  4. CYTOPLASMIC FUCOSYLATION
    Christopher West; Fiscal Year: 1993
    ..migration, spore coat formation, spore germination, and protein transport rate, in the cellular slime mold Dictyostelium discoideum...
  5. INTRACELLULAR ROLE OF CLATHRIN AND ITS REGULATION
    THERESA O HALLORAN; Fiscal Year: 2007
    ..Our experimental strategy is to use Dictyostelium as a model system...
  6. MYOSIN MOVEMENT IN VITRO--MOLECULAR CHARACTERIZATION
    James Spudich; Fiscal Year: 1999
    ..Our demonstrations that we can use Dictyostelium to express large amounts of functional myosin and soluble fragments that contain the motor domain allow us to ..
  7. Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    DIANE BARBER; Fiscal Year: 2007
    ..A novel DNHE1 in Drosophila that binds an ERM ortholog, and a novel DdNHE1 in Dictyostelium discoideum that is necessary for cell polarity and chemotaxis were identified, suggesting that actin anchoring ..
  8. ROLE OF MDR-RELATED GENES IN DICTYOSTELIUM DEVELOPMENT
    Adam Kuspa; Fiscal Year: 1999
    ..While the development of Dictyostelium is simpler than that of metazoans, resulting in a ball of spores held on a cellular stalk, proportioning of ..
  9. Spatial regulation of cytoskeleton during chemotaxis
    Chang Y Chung; Fiscal Year: 2010
    ..is necessary for many biological functions, including wound healing, axonal guidance, and the aggregation of Dictyostelium cells. Chemotaxis also plays a role in disease states such as arthritis, cancer, and multiple sclerosis...
  10. Spatial regulation of cytoskeleton during chemotaxis
    Chang Y Chung; Fiscal Year: 2010
    ..is necessary for many biological functions, including wound healing, axonal guidance, and the aggregation of Dictyostelium cells. Chemotaxis also plays a role in disease states such as arthritis, cancer, and multiple sclerosis...
  11. SEQUENCING THE DICTYOSTELIUM GENOME
    Adam Kuspa; Fiscal Year: 2004
    ..b>Dictyostelium is a social amoeba whose study has contributed to our understanding of diverse biological processes common to ..
  12. MESSENGER RNA METABOLISM IN DICTYOSTELIUM AND YEAST
    Allan Jacobson; Fiscal Year: 1992
    ..Therefore, we propose to address the possibility that specific elements (sequences or structures) of unstable Dictyostelium and yeast mRNAs are responsible for the instability of those mRNAs...
  13. MOLECULAR GENETIC ANALYSIS OF MOTILITY: MYOSIN CHAINS
    Rex Chisholm; Fiscal Year: 1990
    ..cDNA clones which encode the Dictyostelium MLCs have recently been isolated...
  14. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    ..We are using the simple amoeba Dictyostelium discoideum as a model system for identifying signaling pathways that regulate myosin assembly...
  15. Molecular Basis for Protein-Phospholipid Interaction
    Jon Lomasney; Fiscal Year: 2005
    ..C (PLC), and the small G protein ARF; as a regulator of the actin cytoskeleton directing cytokinesis in Dictyostelium, and acting as a regulator of endo and exocytosis...
  16. Spatial regulation of cytoskeleton during chemotaxis
    CHANG CHUNG; Fiscal Year: 2007
    ..neutrophils during wound healing, homing of thymocytes, migration of neural crest cells, and aggregation of Dictyostelium. The first step of chemotactic movement is a chemoattractant mediated increase in F-actin polymerization at ..
  17. MOLECULAR ANALYSIS OF CYTOKINESIS IN DICTYOSTELIUM
    Arturo De Lozanne; Fiscal Year: 2003
    ..Toward that goal, three proteins required for cytokinesis in Dictyostelium have been identified...
  18. MOLECULAR ANALYSIS OF CYTOKINESIS IN DICTYOSTELIUM
    Arturo De Lozanne; Fiscal Year: 2006
    ..Toward that goal, three proteins required for cytokinesis in Dictyostelium have been identified...
  19. ROLE OF SIGNAL TRANSDUCTION IN DICTYOSTELIUM DEVELOPMENT
    Peter Devreotes; Fiscal Year: 1992
    ..Recent observations demonstrate that G protein-linked signaling systems are present in microorganisms such as Dictyostelium. Dictyostelium is uniquely suited for studies of chemotaxis in eucaryotic cells and the role of signal ..
  20. CYTOKINESIS IN DICTYOSTELIUM--A MOLECULAR ANALYSIS
    James Spudich; Fiscal Year: 2001
    ..Key to a long term undertaking to solve this problem is the judicious choice of a model system. Dictyostelium discoideum is a model of choice because it's behavioral characteristics during mitosis and cytokinesis are ..
  21. TARGETING OF LYSOSOMAL ENZYMES IN DICTYOSTELIUM
    James Cardelli; Fiscal Year: 1993
    ..transport, modification and proteolytic processing of 3 lysosomal enzymes in the simple eukaryote Dictyostelium discoideum, an organism amenable to these studies because of the ease in which it can be manipulated ..
  22. SIGNAL TRANSDUCTION AND DICTYOSTELIUM DEVELOPMENT
    Peter Devreotes; Fiscal Year: 1993
    ..pathways play an fundamental role in chemotaxis, cell-cell signaling, and ligand-induced gene expression in Dictyostelium. In the course of its developmental program, this simple metazoan expresses a family of four cell surface cAMP ..