cryptosporidium parvum

Summary

Summary: A species of parasitic protozoa that infects humans and most domestic mammals. Its oocysts measure five microns in diameter. These organisms exhibit alternating cycles of sexual and asexual reproduction.

Top Publications

  1. pmc A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    Xian Ming Chen
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 282:28929-38. 2007
  2. pmc NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS Pathog 5:e1000681. 2009
  3. pmc MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    J Infect Dis 202:125-35. 2010
  4. ncbi Seven years' experience with Cryptosporidium parvum in Guinea-Bissau, West Africa
    M Perch
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Denmark
    Ann Trop Paediatr 21:313-8. 2001
  5. ncbi Cryptosporidium hominis: experimental challenge of healthy adults
    Cynthia L Chappell
    The University of Texas Health Science Center at Houston, School of Public Health and Medical School, Houston, Texas 77030, USA
    Am J Trop Med Hyg 75:851-7. 2006
  6. pmc MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    Int J Parasitol 41:397-403. 2011
  7. pmc Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR
    Jaco J Verweij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1220-3. 2004
  8. pmc NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection
    STEVEN P O'HARA
    Division of Gastroenterology and Hepatology, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 285:216-25. 2010
  9. ncbi Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB
    Xian Ming Chen
    The Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 175:7447-56. 2005
  10. ncbi Host immune response to Cryptosporidium parvum infection
    Franz Petry
    Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, D 55131 Mainz, Germany
    Exp Parasitol 126:304-9. 2010

Detail Information

Publications304 found, 100 shown here

  1. pmc A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    Xian Ming Chen
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 282:28929-38. 2007
    ..Infection of cultured human cholangiocytes with Cryptosporidium parvum, a parasite that causes intestinal and biliary disease, results in decreased expression of primary let-7i ..
  2. pmc NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS Pathog 5:e1000681. 2009
    b>Cryptosporidium parvum is a protozoan parasite that infects the gastrointestinal epithelium and causes diarrheal disease worldwide. Innate epithelial immune responses are key mediators of the host's defense to C. parvum...
  3. pmc MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    J Infect Dis 202:125-35. 2010
    ..We have demonstrated previously that Cryptosporidium parvum infection down-regulates microRNA-98 (miR-98) and let-7 to induce CIS expression in biliary epithelial ..
  4. ncbi Seven years' experience with Cryptosporidium parvum in Guinea-Bissau, West Africa
    M Perch
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Denmark
    Ann Trop Paediatr 21:313-8. 2001
    ..b>Cryptosporidium parvum, found in 7...
  5. ncbi Cryptosporidium hominis: experimental challenge of healthy adults
    Cynthia L Chappell
    The University of Texas Health Science Center at Houston, School of Public Health and Medical School, Houston, Texas 77030, USA
    Am J Trop Med Hyg 75:851-7. 2006
    ..Cryptosporidium hominis 10 oocysts) and is clinically is infectious for healthy adults (ID(50) = similar to C. parvum-induced illness. In contrast to C. parvum, C. hominis elicted a serum IgG response in most infected persons...
  6. pmc MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    Int J Parasitol 41:397-403. 2011
    b>Cryptosporidium parvum is a protozoan parasite that infects gastrointestinal epithelial cells and causes diarrhoeal disease in humans and animals globally. Pathological changes following C...
  7. pmc Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR
    Jaco J Verweij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1220-3. 2004
    ..The use of this assay in a diagnostic laboratory would provide sensitive and specific diagnosis of the main parasitic diarrheal infections and could improve patient management and infection control...
  8. pmc NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection
    STEVEN P O'HARA
    Division of Gastroenterology and Hepatology, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 285:216-25. 2010
    ..Here, we identify a novel transcriptional mechanism induced by the protozoan parasite Cryptosporidium parvum and Gram(-) bacteria-derived lipopolysaccharide (LPS) mediating let-7i promoter silencing in human biliary ..
  9. ncbi Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB
    Xian Ming Chen
    The Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 175:7447-56. 2005
    Infection of epithelial cells by Cryptosporidium parvum triggers a variety of host-cell innate and adaptive immune responses including release of cytokines/chemokines and up-regulation of antimicrobial peptides...
  10. ncbi Host immune response to Cryptosporidium parvum infection
    Franz Petry
    Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, D 55131 Mainz, Germany
    Exp Parasitol 126:304-9. 2010
    ..Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis...
  11. pmc Evaluation of the Triage Micro Parasite Panel for detection of Giardia lamblia, Entamoeba histolytica/Entamoeba dispar, and Cryptosporidium parvum in patient stool specimens
    S E Sharp
    Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Clin Microbiol 39:332-4. 2001
    ..dispar, and three were positive for Cryptosporidium parvum as determined by both methods. There was one false positive by Triage (C...
  12. pmc Cryptosporidium parvum genes containing thrombospondin type 1 domains
    Mingqi Deng
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Infect Immun 70:6987-95. 2002
    b>Cryptosporidium parvum is recognized as an enteropathogen of great worldwide medical and veterinary importance, yet understanding of its pathogenesis has been hampered in part by limited knowledge of the invasion machinery of this ..
  13. pmc TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis
    STEVEN P O'HARA
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, and Mayo Clinic Center for Cell Signaling, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Parasitol 97:813-21. 2011
    ..by gram-negative lipopolysaccharide (LPS), is upregulated in cholangiocytes in response to infection with Cryptosporidium parvum in vitro and contributes to nuclear factor-kappaB (NF-kB) activation...
  14. ncbi Proteomes and transcriptomes of the Apicomplexa--where's the message?
    J M Wastling
    Department of Pre clinical Veterinary Science, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    Int J Parasitol 39:135-43. 2009
    ..Toxoplasma gondii, Cryptosporidium parvum, Neospora caninum and Theileria spp...
  15. pmc Cryptosporidium species and subtypes and clinical manifestations in children, Peru
    Vitaliano A Cama
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Emerg Infect Dis 14:1567-74. 2008
    ..genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children...
  16. pmc Genotype analysis of Cryptosporidium spp. prevalent in a rural village in Hwasun-gun, Republic of Korea
    Jae Hwan Park
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
    Korean J Parasitol 44:27-33. 2006
    ..hominis is a new and unique finding in the present study. It is suggested that human cryptosporidiosis in the studied area is caused by mixtures of C. hominis and C. parvum oocysts originating from both inhabitants and domestic animals...
  17. ncbi Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplication
    Dominique Madern
    Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale CEA CNRS UJF, Grenoble, France
    Mol Biol Evol 21:489-97. 2004
    ..expressed the L-lactate dehydrogenase (LDH) and L-malate dehydrogenase (malDH) genes from the apicomplexan Cryptosporidium parvum (CpLDH1 and CpMalDH1) as maltose-binding protein (MBP) fusion proteins in Escherichia coli...
  18. pmc Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection
    Tarek K Zaalouk
    Department of Adult and Paediatric Gastroenterology, Barts and the London School of Medicine, London, United Kingdom
    Infect Immun 72:2772-9. 2004
    ..In this study, the interplay between the enteric protozoan parasite Cryptosporidium parvum and host epithelial beta-defensin expression was investigated...
  19. ncbi Risk factors associated with Cryptosporidium parvum infection in dairy cattle in southeastern New York State
    H O Mohammed
    Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Parasitol 83:1-13. 1999
    ..epidemiologic study was carried out to identify factors associated with the risk of infection with Cryptosporidium parvum in dairy herds in southeastern New York state...
  20. ncbi Distribution of Cryptosporidium parvum subtypes in calves in eastern United States
    Lihua Xiao
    Division of Parasitic Diseases, Center for Disease Control and Prevention, Atlanta, GA 30341, USA
    Parasitol Res 100:701-6. 2007
    b>Cryptosporidium parvum DNA from 175 neonatal calves on 16 farms in eight eastern states in the United States was subtyped by sequence analysis of the 60-kDa glycoprotein gene to determinate the parasite genetic diversity...
  21. pmc Development of Cryptosporidium parvum-induced gastrointestinal neoplasia in severe combined immunodeficiency (SCID) mice: severity of lesions is correlated with infection intensity
    Gabriela Certad
    Ecologie du Parasitisme EA3609 Université de Lille 2, IFR 142, Institut Pasteur de Lille, Lille, France
    Am J Trop Med Hyg 82:257-65. 2010
    We reported previously that Cryptosporidium parvum was able to induce intestinal tumors in severe combined immunodeficiency (SCID) mice treated with corticoids...
  22. pmc Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, USA
    J Infect Dis 201:160-9. 2010
    ..We report here that the protozoan parasite Cryptosporidium parvum induced B7-H1 expression in cultured human cholangiocytes...
  23. ncbi Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain
    Gabriela Certad
    Laboratoire Biologie et Diversité des Pathogènes Eucaryotes Emergents BDEEP, Institut Pasteur de Lille IFR 142 Université Lille Nord de France EA4547, Lille, France
    Int J Parasitol 40:1469-75. 2010
    We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C...
  24. ncbi The thrombospondin-related protein CpMIC1 (CpTSP8) belongs to the repertoire of micronemal proteins of Cryptosporidium parvum
    Lorenza Putignani
    Unit of Microbiology and Virology, Children s Hospital and Research Institute Bambino Gesu, Piazza S Onofrio 4, 00165 Rome, Italy
    Mol Biochem Parasitol 157:98-101. 2008
    Bioinformatic data show that, in addition to TRAP-C1, Cryptosporidium parvum encodes 11 thrombospondin-related proteins (CpTSP2 through CpTSP12), none of which has been characterized yet...
  25. pmc Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum
    Alan T Bankier
    Medical Research Council MRC Laboratory of Molecular Biology, Cambridge CB 2 2QH, UK
    Genome Res 13:1787-99. 2003
    The apicomplexan Cryptosporidium parvum is one of the most prevalent protozoan parasites of humans. We report the physical mapping of the genome of the Iowa isolate, sequencing and analysis of chromosome 6, and approximately 0...
  26. pmc Genetic analysis of a Cryptosporidium parvum human genotype 1 isolate passaged through different host species
    D E Akiyoshi
    Division of Infectious Diseases, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA
    Infect Immun 70:5670-5. 2002
    b>Cryptosporidium parvum TU502, a genotype 1 isolate of human origin, was passaged through three different mammalian hosts, including humans, pigs, and calves...
  27. pmc Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model
    Gabriela Certad
    Centre d Infection et d Immunité de Lille CIIL, Institut Pasteur de Lille, Inserm U1019, CNRS UMR 8402, Universite Lille Nord de France, Lille, France
    Appl Environ Microbiol 78:1746-51. 2012
    In the present work, we report the characterization of a Cryptosporidium parvum strain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone ..
  28. ncbi Host intestinal epithelial response to Cryptosporidium parvum
    Mingqi Deng
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Adv Drug Deliv Rev 56:869-84. 2004
    b>Cryptosporidium parvum is an obligate intracellular protozoan parasite that is a well-recognized cause of diarrhea in humans and animals throughout the world, and is associated with a substantial degree of morbidity and mortality in ..
  29. ncbi Study of 18S rRNA and rDNA stability by real-time RT-PCR in heat-inactivated Cryptosporidium parvum oocysts
    Melanie Fontaine
    Suez Environnement Local Services, CIRSEE, 38 Avenue du President Wilson, 78230 Le Pecq, France
    FEMS Microbiol Lett 226:237-43. 2003
    The public health problem posed by Cryptosporidium parvum has led the water supply industry to develop analytical tools for detecting viable oocysts in water...
  30. pmc The Cryptosporidium parvum transcriptome during in vitro development
    Mary J Mauzy
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 7:e31715. 2012
    ..The transcript abundance for 3,302 genes (87%) of the Cryptosporidium parvum protein coding genome was elucidated over a 72 hr infection within HCT8 cells using Real Time-PCR...
  31. pmc Mediation of Cryptosporidium parvum infection in vitro by mucin-like glycoproteins defined by a neutralizing monoclonal antibody
    A M Cevallos
    Division of Geographic Medicine and Infectious Diseases, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 68:5167-75. 2000
    The protozoan parasite Cryptosporidium parvum is a significant cause of diarrheal disease worldwide. Attachment to and invasion of host intestinal epithelial cells by C...
  32. ncbi Construction and analysis of full-length cDNA library of Cryptosporidium parvum
    Junya Yamagishi
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Parasitol Int 60:199-202. 2011
    A full-length cDNA library was constructed from the sporozoite of Cryptosporidium parvum. Normalized clones were subjected to Solexa shotgun sequencing, and then complete sequences for 1066 clones were reconfigured...
  33. pmc Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum
    Sulagna Banerjee
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Glycobiology 19:331-6. 2009
    ..These results suggest the possibility that O-GlcNAc modification of nucleocytosolic proteins also has function(s) in simple eukaryotes...
  34. ncbi Glycoprotein 60 diversity in C. hominis and C. parvum causing human cryptosporidiosis in NSW, Australia
    L S Waldron
    Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Exp Parasitol 122:124-7. 2009
    ..The subtypes identified have global distributions and indicate that anthroponotic and zoonotic transmission routes contribute to sporadic human cryptosporidiosis in NSW...
  35. ncbi Impact of bathers on levels of Cryptosporidium parvum oocysts and Giardia lamblia cysts in recreational beach waters
    Deirdre Sunderland
    Department of Environmental Health Sciences, Division of Environmental Health Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Water Res 41:3483-9. 2007
    ..collected on weekends and weekdays during 11 consecutive summer weeks were tested for potentially viable Cryptosporidium parvum oocysts and Giardia lamblia cysts using the multiplexed fluorescence in situ hybridization (FISH) method...
  36. ncbi Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src
    Xian Ming Chen
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 125:216-28. 2003
    b>Cryptosporidium parvum invasion of epithelia requires polymerization of host cell actin at the attachment site. We analyzed the role of host cell c-Src, a cytoskeleton-associated protein tyrosine kinase, in C...
  37. ncbi Distribution of Cryptosporidium subtypes in humans and domestic and wild ruminants in Portugal
    Margarida Alves
    Unidade de Protozoários Oportunistas VIH e Outras Protozooses, Unidade de Parasitologia e Microbiologia Médicas UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 96, 1349 008, Lisboa, Portugal
    Parasitol Res 99:287-92. 2006
    To investigate the transmission of cryptosporidiosis in Portugal, Cryptosporidium hominis and Cryptosporidium parvum from HIV-infected patients, cattle, and wild ruminants were characterized by sequence analysis of the 60-kDa glycoprotein ..
  38. ncbi Complete genome sequence of the apicomplexan, Cryptosporidium parvum
    Mitchell S Abrahamsen
    Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Science 304:441-5. 2004
    The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients...
  39. ncbi Occurrence of Cryptosporidium parvum and Giardia duodenalis in healthy adult domestic ruminants
    José Antonio Castro-Hermida
    Laboratorio de Parasitologia, Centro de Investigaciones Agrarias de Mabegondo Xunta de Galicia, Carretera C 542 de Betanzos a Mesón do Vento, Km 7, 5 CP 15318, Abegondo A Coruña, Galicia, Spain
    Parasitol Res 101:1443-8. 2007
    ..Assemblage B of G. duodenalis was also detected in one sheep sample. These animals should be considered as a possible source of cryptosporidiosis and giardiosis, thereby maintaining the infections on farms and in herds...
  40. ncbi Proteomics analysis and protein expression during sporozoite excystation of Cryptosporidium parvum (Coccidia, Apicomplexa)
    William J Snelling
    Centre for Molecular Biosciences, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, Northern Ireland
    Mol Cell Proteomics 6:346-55. 2007
    ..This study examined the zoonotic species Cryptosporidium parvum at two important stages of its life cycle: the non-excysted (transmissive) and excysted (infective) forms...
  41. ncbi Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis
    X M Chen
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 120:1774-83. 2001
    BACKGROUND & AIMS: Our previous studies have shown that Cryptosporidium parvum induces biliary epithelial cell apoptosis in vivo and causes apoptosis in bystander uninfected biliary epithelia in vitro. We analyzed C...
  42. pmc Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall
    Anirban Chatterjee
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Eukaryot Cell 9:84-96. 2010
    b>Cryptosporidium parvum oocysts, which are spread by the fecal-oral route, have a single, multilayered wall that surrounds four sporozoites, the invasive form. The C...
  43. pmc Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model
    Autumn S Downey
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Antimicrob Agents Chemother 52:3106-12. 2008
    ..anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% growth inhibition in human enterocytic HCT-8 cells by a ..
  44. pmc A survey of cryptosporidiosis among 2,541 residents of 25 coastal islands in Jeollanam-Do (Province), Republic of Korea
    Jae Hwan Park
    Department of Parasitology and Tropical Medicine, Seoul Nationla University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
    Korean J Parasitol 44:367-72. 2006
    ..2%). The results of the present survey indicate that human Cryptosporidium infections (due to Cryptosporidium hominis and/or C. parvum) are maintained at a relatively low prevalence on coastal islands of Jeollanam-do, Republic of Korea...
  45. ncbi Community cohort study of Cryptosporidium parvum infections: sex-differential incidences associated with BCG and diphtheria-tetanus-pertussis vaccinations
    Palle Valentiner-Branth
    Bandim Health Project, Danish Epidemiology Science Centre, Statens Serum Institut, Apartado 861, Bissau, Guinea Bissau, Denmark
    Vaccine 25:2733-41. 2007
    ..Using an existing data set, we examined whether vaccinations were associated with gender-differential incidences of Cryptosporidium parvum infection.
  46. ncbi Cryptosporidium parvum regulation of human epithelial cell gene expression
    Mingqi Deng
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Int J Parasitol 34:73-82. 2004
    b>Cryptosporidium parvum is an obligate intracellular protozoan capable of causing life-threatening diarrhoeal disease in immunocompromised individuals...
  47. pmc Comparison of PCR and microscopy for detection of Cryptosporidium parvum in human fecal specimens: clinical trial
    U M Morgan
    World Health Organisation Collaborating Center for the Molecular Epidemiology of Infectious Diseases, Division of Veterinary and Biomedical Sciences, Murdoch University, WA, Australia
    J Clin Microbiol 36:995-8. 1998
    ..Sensitivity, specificity, ability to genotype, ease of use, and adaptability to batch testing make PCR a useful tool for future diagnosis and studies on the molecular epidemiology of Cryptosporidium infections...
  48. pmc Detection of Giardia lamblia, Entamoeba histolytica/Entamoeba dispar, and Cryptosporidium parvum antigens in human fecal specimens using the triage parasite panel enzyme immunoassay
    L S Garcia
    LSG and Associates, Diagnostic Medical Parasitology Consulting Training Services, Santa Monica, California 90402, USA
    J Clin Microbiol 38:3337-40. 2000
    ..dispar, and Cryptosporidium parvum in fresh or fresh, frozen, unfixed human fecal specimens...
  49. ncbi Cryptosporidium parvum: identification of a new surface adhesion protein on sporozoite and oocyst by screening of a phage-display cDNA library
    Longquan Yao
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun, PR China
    Exp Parasitol 115:333-8. 2007
    b>Cryptosporidium parvum is a significant cause of diarrheal disease worldwide. The specific molecules that mediate C. parvum-host interaction and the molecular mechanisms involved in the pathogenesis are unknown...
  50. ncbi Genetic classification of Cryptosporidium isolates from humans and calves in Slovenia
    B Soba
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Parasitology 135:1263-70. 2008
    ..In humans, C. hominis Ia (subtype IaA17R3) and Ib (IbA10G2) and Cryptosporidium parvum IIa (IIaA9G1R1, IIaA11G2R1, IIaA13R1, IIaA14G1R1, IIaA15G1R1, IIaA15G2R1, IIaA16G1R1, IIaA17G1R1 and ..
  51. ncbi Cryptosporidium parvum appears to lack a plastid genome
    G Zhu
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Microbiology 146:315-21. 2000
    Surprisingly, unlike most Apicomplexa, Cryptosporidium parvum appears to lack a plastid genome...
  52. ncbi Cryptosporidium infections in inbred strains of mice
    F J Enriquez
    Division of Biotechnology, Arizona Health Sciences Center, University of Arizona, Tucson 85724
    J Protozool 38:100S-102S. 1991
    ..The numbers of parasites harbored in these NK cell-deficient beige mice were, however, considerably lower than those seen in neonatal mice. Adult inbred mouse strains susceptible to Cryptosporidium infections are discussed...
  53. pmc Involvement of host calpain in the invasion of Cryptosporidium parvum
    Gregorio Perez-Cordon
    Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA
    Microbes Infect 13:103-7. 2011
    b>Cryptosporidium parvum induces the formation of an actin-dense plaque which is essential for the successful invasion of epithelial cells. Host molecules that are involved in the regulation of this cytoskeleton reorganization are unknown...
  54. ncbi Low prevalence of Cryptosporidium parvum in hospitalized children in Kota Bharu, Malaysia
    B S Menon
    Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian
    Southeast Asian J Trop Med Public Health 32:319-22. 2001
    The aim of this prospective study was to determine the prevalence of Cryptosporidium parvum in hospitalized children in Kota Bharu, Malaysia...
  55. pmc Infection with Cryptosporidium hominis provides incomplete protection of the host against Cryptosporidium parvum
    Abhineet Sheoran
    Department of Biomedical Sciences, Tufts University, North Grafton, MA, USA
    J Infect Dis 205:1019-23. 2012
    Cryptosporidium hominis and Cryptosporidium parvum, which infect humans equally, are genetically/antigenically almost identical. It remains unclear, however, whether infection with C. hominis protects against C. parvum...
  56. ncbi Prevalence and analysis of potential risk factors for Cryptosporidium parvum infection in lambs in Zaragoza (northeastern Spain)
    A C Causape
    Departamento de Patologia Animal, Parasitologia y Enfermedades Parasitarias, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain
    Vet Parasitol 104:287-98. 2002
    ..Additionally, lambs 8-14 days of age were less likely to be infected at the first lambing period and in spring/autumn. Cryptosporidial infection was also detected in 16 ewes (7.8%) which excreted few oocysts and without diarrhoea...
  57. ncbi Cryptosporidium p30, a galactose/N-acetylgalactosamine-specific lectin, mediates infection in vitro
    Najma Bhat
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 282:34877-87. 2007
    ..Previously, we described a surface-associated Gal/GalNAc-specific lectin activity in sporozoites of Cryptosporidium parvum. Here we describe p30, a 30-kDa Gal/GalNAc-specific lectin isolated from C...
  58. ncbi Single-chain variable fragment antibodies selected by phage display against the sporozoite surface antigen P23 Of Cryptosporidium parvum
    Jeanine I Boulter-Bitzer
    Department of Environmental Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Parasitol 95:75-81. 2009
    b>Cryptosporidium parvum, an apicomplexan parasite transmitted via animal fecal wastes, is the causative agent of cryptosporidiosis...
  59. ncbi Prevalences of Giardia lamblia and Cryptosporidium parvum infection in adults presenting with chronic diarrhoea
    J Yakoob
    Department of Medicine, Aga Khan University, Karachi B, Pakistan
    Ann Trop Med Parasitol 104:505-10. 2010
    Giardia lamblia and Cryptosporidium parvum are both waterborne pathogens associated with diarrhoea in developing countries...
  60. ncbi Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infection
    Tesfaye Sisay Tessema
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Immunobiology 214:454-66. 2009
    b>Cryptosporidium parvum is an intracellular parasite causing enteritis which can become life-threatening in the immunocompromised host. CD4+ T cells and interferon (IFN)-gamma play dominant roles in host immune response to infection...
  61. pmc Recovery and enumeration of Cryptosporidium parvum from animal fecal matrices
    Cheryl M Davies
    Centre for Water and Waste Technology, School of Civil and Environmental Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 69:2842-7. 2003
    Accurate quantification of Cryptosporidium parvum oocysts in animal fecal deposits on land is an essential starting point for estimating watershed C. parvum loads...
  62. ncbi Quantitative comparison of different purification and detection methods for Cryptosporidium parvum oocysts
    Sirri Kar
    Department of Biology, Namik Kemal University, 59030 Tekirdag, Turkey
    Vet Parasitol 177:366-70. 2011
    b>Cryptosporidium parvum (C. parvum) is the causal agent of cryptosporidiosis in many animals, mainly cattle, and possesses a high zoonotic potential. It occurs worldwide and ubiquitously. Detection of C...
  63. ncbi Cryptosporidium parvum infection rapidly induces a protective innate immune response involving type I interferon
    Farah M Barakat
    Queen Mary University of London, Institute of Cell and Molecular Science, Centre for Gastroenterology, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London, United Kingdom
    J Infect Dis 200:1548-55. 2009
    ..Treatment with anti-IFN-alpha/beta, however, did not reduce early expression of IFN-gamma. These findings identify a novel early innate host response against Cryptosporidium parvum involving IFN-alpha/beta.
  64. ncbi Cryptosporidium parvum: identification and characterization of an acid phosphatase
    María Magdalena Aguirre-García
    Department of Experimental Medicine, School of Medicine, UNAM, Dr Balmis 148, Colonia Doctores, Mexico City, DF 06726, Mexico
    Parasitol Res 101:85-9. 2007
    ..Acid phosphatases can also inhibit the respiratory burst of human neutrophils. In Cryptosporidium parvum, a protozoan parasitic, the study of enzymes is limited...
  65. ncbi Comparison of fluorescence, antigen and PCR assays to detect Cryptosporidium parvum in fecal specimens
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Tubingen, Germany
    Diagn Microbiol Infect Dis 43:283-8. 2002
    ..None was obtained from 60 samples negative in the three other assays. PCR assays did not increase the detection rate. Antigen EIA or DFA appear sufficient for routine Cryptosporidium screening of fecal samples...
  66. ncbi Biology of Cryptosporidium parvum in pigs: from weaning to market
    N J Guselle
    Gastrointestinal Research Group, University of Calgary, AB, Canada T2N 4N1
    Vet Parasitol 113:7-18. 2003
    b>Cryptosporidium parvum is commonly identified as infecting domestic livestock and humans. Prevalence of C...
  67. ncbi Identification of genotypically mixed Cryptosporidium parvum populations in humans and calves
    Sultan Tanriverdi
    Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey
    Mol Biochem Parasitol 130:13-22. 2003
    Genotypic analyses of Cryptosporidium parvum oocysts have divided the species into two genotypes, referred to as type 1 and type 2. Although humans are susceptible to both types, mixed type 1/type 2 infections have rarely been identified...
  68. ncbi Prophylactic use of decoquinate for infections with Cryptosporidium parvum in experimentally challenged neonatal calves
    Dale A Moore
    Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 223:839-45. 2003
    To evaluate the effect of daily oral administration of decoquinate to neonatal calves experimentally challenged with various numbers of Cryptosporidium parvum oocysts.
  69. ncbi The occurrence of Cryptosporidium parvum and C. muris in wild rodents and insectivores in Spain
    J Torres
    Departament de Microbiologia i Parasitologia Sanitaries, Facultat de Farmacia, Universitat de Barcelona, Avda Joan XXIII Sn, 08028, Barcelona, Spain
    Vet Parasitol 92:253-60. 2000
    ..This is the first study to report the infection of M. spretus and C. russula by C. parvum and the first finding of C. muris in M. spretus...
  70. ncbi Synonymous codon usage in Cryptosporidium parvum: identification of two distinct trends among genes
    R J Grocock
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Int J Parasitol 31:402-12. 2001
    The usage of alternative synonymous codons in the apicomplexan Cryptosporidium parvum has been investigated. A data set of 54 genes was analysed. Overall, A- and U-ending codons predominate, as expected in an A+T-rich genome...
  71. pmc Spinacia oleracea L. leaf stomata harboring Cryptosporidium parvum oocysts: a potential threat to food safety
    Dumitru Macarisin
    United States Department of Agriculture Agricultural Research Service USDA ARS, Beltsville Agricultural Research Center BARC, Environmental Microbial and Food Safety Laboratory, 10300 Baltimore Avenue, Bldg 173, BARC East, Beltsville, MD 20705, USA
    Appl Environ Microbiol 76:555-9. 2010
    b>Cryptosporidium parvum is a cosmopolitan microscopic protozoan parasite that causes severe diarrheal disease (cryptosporidiosis) in mammals, including humans and livestock...
  72. pmc Comparative sensitivity of PCR primer sets for detection of Cryptosporidium parvum
    Jae Ran Yu
    Department of Environmental and Tropical Medicine, Konkuk University, School of Medicine, Seoul, Korea
    Korean J Parasitol 47:293-7. 2009
    ..We compared the sensitivity of 7 PCR primer sets for detection of Cryptosporidium parvum. Each target gene was amplified by PCR or nested PCR with serially diluted DNA extracted from purified C...
  73. ncbi The role of free-ranging, captive, and domestic birds of Western Poland in environmental contamination with Cryptosporidium parvum oocysts and Giardia lamblia cysts
    Anna C Majewska
    Department of Biology and Medical Parasitology, Faculty Medicine I, Poznan University of Medical Sciences, Poznan, Poland
    Parasitol Res 104:1093-9. 2009
    As Cryptosporidium parvum and Giardia lamblia can be disseminated in the environment by avian hosts, a total of 499 fecal dropping from 308 free-ranging, 90 captive, and 101 domestic birds were tested by conventional, immunological, and ..
  74. pmc Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model
    Lourrany B Costa
    Center for Global Health, University of Virginia, Charlottesville, Virginia 22908, USA
    J Parasitol 97:1113-20. 2011
    ..Depressed TLR2 and 4 signaling and Th1 cytokine response may be important in the mechanisms underlying the vicious cycle of malnutrition and enteric infection...
  75. pmc Significance of wall structure, macromolecular composition, and surface polymers to the survival and transport of Cryptosporidium parvum oocysts
    Michael B Jenkins
    Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York 14853, USA
    Appl Environ Microbiol 76:1926-34. 2010
    ..composition of the oocyst wall are primary factors determining the survival and hydrologic transport of Cryptosporidium parvum oocysts outside the host...
  76. ncbi Incidence of Cryptosporidium parvum in the dairy cattle population in a New York City Watershed
    Simon R Starkey
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Parasitol 131:197-205. 2005
    ..study of 2-year duration was conducted to determine the risk, as measured by incidence rate, of Cryptosporidium parvum infection among dairy cattle in the Catskill/Delaware Watershed of New York City (NYC), and the factors ..
  77. ncbi Epidemiologic and environmental investigation of a recreational water outbreak caused by two genotypes of Cryptosporidium parvum in Ohio in 2000
    Els Mathieu
    Epidemic Intelligence Service, Division of Parasitic Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341 3724, USA
    Am J Trop Med Hyg 71:582-9. 2004
    ..chain reaction (PCR) analysis, which showed the presence of both the human and bovine genotypes of Cryptosporidium parvum in case-patients and samples from the filter of pool A...
  78. ncbi Equine Cryptosporidium parvum infections in western Poland
    Anna C Majewska
    Department of Biology and Medical Parasitology, Poznan University of Medical Sciences, 61 701, Poznan, Poland
    Parasitol Res 93:274-8. 2004
    ..hippotherapy, and racing at ten commercial and government-run stables in western Poland were tested for Cryptosporidium parvum oocysts by microscopic examination of Ziehl-Neelsen stained smears, enzyme immunoassay, and combined ..
  79. ncbi Prevalence and abundance of Cryptosporidium parvum and giardia spp. in wild rural rodents from the Mazury Lake District region of Poland
    A Bajer
    Department of Parasitology, Institute of Zoology, University of Warszawa, Poland
    Parasitology 125:21-34. 2002
    ..Quantitative associations were confined to the 2 vole species in the study. These results are discussed in relation to the importance of wild rodents as reservoir hosts and sources of infection for local human communities...
  80. pmc The terminal sialic acid of glycoconjugates on the surface of intestinal epithelial cells activates excystation of Cryptosporidium parvum
    Naheed Choudhry
    Centre for Gastroenterology, Institute for Cell and Molecular Science, Barts and the London School of Medicine, Newark Street, University of London, London E1 2AD, United Kingdom
    Infect Immun 76:3735-41. 2008
    The apicomplexan Cryptosporidium parvum reproduces in the intestinal epithelial cells of many mammalian species and is an agent of the important diarrheal disease cryptosporidiosis...
  81. ncbi Efficacy of vegetated buffer strips for retaining Cryptosporidium parvum
    Kenneth W Tate
    Department of Agronomy and Range Science, One Shields Avenue, University of California, Davis, CA 95616 8515, USA
    J Environ Qual 33:2243-51. 2004
    Overland and shallow subsurface hydrologic transport of pathogenic Cryptosporidium parvum oocysts from cattle feces into surface drinking water supplies is a major concern on annual grasslands in California's central and southern Sierra ..
  82. pmc A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases
    Thomas V Riera
    Departments of Biochemistry and Chemistry, Brandeis University, Waltham, Massachusetts 02454, USA
    Biochemistry 47:8689-96. 2008
    ..catalytic cycle, we have delineated the kinetic mechanism of IMPDH from the pathogenic protozoan parasite Cryptosporidium parvum ( CpIMPDH), which was obtained from a bacterial source through horizontal gene transfer, and its host ..
  83. pmc Charting the proteome of Cryptosporidium parvum sporozoites using sequence similarity-based BLAST searching
    A M A M Z Siddiki
    Department of Preclinical Veterinary Sciences, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    J Vet Sci 10:203-10. 2009
    ..The MS BLAST approach was found to be useful during the study and could provide valuable information towards a complete understanding of the unique biology of Cryptosporidium...
  84. ncbi Supplementation with Lactobacillus reuteri or L. acidophilus reduced intestinal shedding of cryptosporidium parvum oocysts in immunodeficient C57BL/6 mice
    J I Alak
    Department of Biology, Tuskegee University, Alabama 36088, USA
    Cell Mol Biol (Noisy-le-grand) 45:855-63. 1999
    The effect of L. acidophilus supplementation to reduce fecal shedding of Cryptosporidium parvum oocysts was compared to L. reuteri using C57BL/6 female mice immunosuppressed by murine leukemia virus (strain LP-BM5) inoculation...
  85. ncbi Subgenotype analysis of Cryptosporidium parvum isolates from humans and animals in Japan using the 60-kDa glycoprotein gene sequences
    Niichiro Abe
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Tennoji ku, Osaka, 543 0026, Japan
    Parasitol Res 99:303-5. 2006
    b>Cryptosporidium parvum is a well-known intestinal parasite which is associated with severe acute diarrhea in humans and animals. This parasite is composed of morphologically identical but genetically different multiple genotypes...
  86. pmc Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum
    Xiaomin Cai
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, 4467 TAMU, College Station, TX 77843 4467, USA
    Eukaryot Cell 4:1211-20. 2005
    ..carrier protein (ACP) from three apicomplexan parasites: surfactin production element (SFP) type in Cryptosporidium parvum (CpSFP-PPT), holo-ACP synthase (ACPS)-type in Plasmodium falciparum (PfACPS-PPT), and both SFP and ACPS ..
  87. ncbi Reducing stunting among children: the potential contribution of diagnostics
    Karen A Ricci
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407 2138, USA
    Nature 444:29-38. 2006
  88. pmc Quantitative evaluation of infectivity change of Cryptosporidium parvum after gamma irradiation
    Soo Ung Lee
    Department of Environmental and Tropical Medicine, Konkuk University School of Medicine, Seoul, Korea
    Korean J Parasitol 47:7-11. 2009
    b>Cryptosporidium parvum is a well-known waterborne and opportunistic intracellular protozoan parasite that causes diarrheal illness. In this study, we quantitatively investigated reduction of the infectivity of C...
  89. ncbi NF-kappaB-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets
    Jody L Gookin
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 290:G164-74. 2006
    ..Using an in vivo model of Cryptosporidium parvum infection, we have examined the location, mechanism of induction, specificity, and consequence of iNOS ..
  90. ncbi The effect of gamma-irradiation on the viability of Cryptosporidium parvum
    J R Yu
    Department of Parasitology, College of Medicine, Konkuk University, Chungju 380 701, South Korea
    J Parasitol 89:639-42. 2003
    b>Cryptosporidium parvum is 1 of the major causative organisms in waterborne diarrheal illness. Not only does C. parvum spread ubiquitously in our environment, it is also highly resistant to harsh environmental conditions and disinfectants...
  91. ncbi Characterization of a Cryptosporidium parvum gene encoding a protein with homology to long chain fatty acid synthetase
    Leonardo Camero
    Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
    J Eukaryot Microbiol 50:534-8. 2003
    We describe here the cloning, sequencing, and characterization of a novel Cryptosporidium parvum gene, encoding a protein with significant homology to the long-chain fatty acyl-CoA synthetase (LCFA, EC 6.2.1.3)...
  92. ncbi Role of Cryptosporidium parvum as a pathogen in neonatal diarrhoea complex in suckling and dairy calves in France
    M Naciri
    INRA, Unité de Pathologie Aviaire et de Parasitologie, Nouzilly, France
    Vet Parasitol 85:245-57. 1999
    This study was carried out to find the importance of Cryptosporidium parvum in diarrhoea of neonatal calves in two types of breeding - suckling and dairy calves - in France. Different agents causing neonatal diarrhoea, E...
  93. ncbi Cryptosporidium parvum infection in bovine neonates: dynamic clinical, parasitic and immunologic patterns
    R Fayer
    United States Department of Agriculture, Agricultural Research Service, Immunology and Disease Resistance Laboratory, Beltsville, MD 20705, USA
    Int J Parasitol 28:49-56. 1998
    ..No differences were detected in mRNA levels for cytokines from lymph node lymphocytes...
  94. ncbi Genetic crosses in the apicomplexan parasite Cryptosporidium parvum define recombination parameters
    Sultan Tanriverdi
    Tufts Cummings School of Veterinary Medicine, Division of Infectious Diseases, North Grafton, MA, USA
    Mol Microbiol 63:1432-9. 2007
    Recombinant progeny lines of Cryptosporidium parvum were generated by coinfecting immunosuppressed mice with two genetically distinct isolates of C. parvum...
  95. ncbi Chronic diarrhea
    James P Keating
    Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO, USA
    Pediatr Rev 26:5-14. 2005
  96. ncbi Molecular analysis of Cryptosporidium parvum HNJ-1 isolated in Japan
    Said Amer
    Laboratory of Sustainable Environmental Biology, Tohoku University, Miyagi, Japan
    J Vet Med Sci 72:1647-9. 2010
    b>Cryptosporidium parvum HNJ-1 is widely used as a reference strain in Japan...
  97. ncbi Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum
    Louisa M MacDonald
    Division of Health Sciences, Murdoch University, Perth, WA, Australia
    Mol Biochem Parasitol 138:89-96. 2004
    ..for the parasitic protozoa Giardia duodenalis and Encephalitozoon intestinalis, and low efficacy with Cryptosporidium parvum. Direct kinetic analysis of the benzimidazole-beta-tubulin interaction was performed using a fluorescence-..
  98. ncbi Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and evaluation of its protective effects
    Hiroaki Shirafuji
    National Research Center for Protozoan Disease, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokaido, Japan
    J Parasitol 91:476-9. 2005
    In this study, P23 of Cryptosporidium parvum sporozoites, an immunodominant surface protein, was stably expressed in Toxoplasma gondii (Tg/P23) and its protective effects were evaluated in a mouse model...
  99. ncbi Genotyping of Cryptosporidium parvum with microsatellite markers
    Giovanni Widmer
    Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    Methods Mol Biol 268:177-87. 2004
    Recent outbreaks of cryptosporidiosis caused by Cryptosporidium parvum in the United States and other countries, as well as the emergence of cryptosporidiosis as a frequent cause of morbidity and mortality in immunodeficient individuals, ..
  100. ncbi Reduction and compaction in the genome of the apicomplexan parasite Cryptosporidium parvum
    Patrick J Keeling
    Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, 3529 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada
    Dev Cell 6:614-6. 2004
    The complete genome of the apicomplexan parasite Cryptosporidium parvum reveals many new insights into apicomplexan biology and evolution, as well as the general process of genome reduction in parasites...
  101. pmc Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro
    Vlasta Ctrnacta
    Charles University in Prague and University Hospital Bulovka, First Faculty of Medicine, Department of Infectious and Tropical Diseases, Prague, Czech Republic
    Exp Parasitol 126:113-6. 2010
    ..that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro...

Research Grants62

  1. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..g. E. Coli, Enterococcus Faecalis, MS2 bacteriophage Poliovirus, Cryptosporidium parvum, Legionelle pneumophila, and Salmonella enterica plus specific chemicals, phenol, and humic acid), ..
  2. The development of probiotic yeast as an inexpensive vaccine delivery platform
    TRACEY JANE LAMB; Fiscal Year: 2013
    ..nature of the immune responses generated will be demonstrated using a mouse model of diarrheal infection, Cryptosporidium parvum. Defined vaccine targets against C. parvum will be expressed by S...
  3. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..PCR/LDR and RT-PCR/LDR will be used to detect the Category B food and water-borne protozoa (Cryptosporidium parvum, Cyclospora cayatanensis, Entamoeba histolytica, Giardia lamblia and Microsporidia) and viruses (..
  4. Purine Salvage Pathway of Cryptosporidium Parvum
    Buddy Ullman; Fiscal Year: 2012
    ..and pharmacology, this proposal offers an interdisciplinary dissection of the purine salvage pathway of Cryptosporidium parvum, a protozoan parasite that is an opportunistic pathogen of people with AIDS and an NIAID Biodefense ..
  5. Partnership for Detection of Infection by Category B Pathogens
    Frances S Ligler; Fiscal Year: 2011
    ..coli, Shigella, Listeria, Cryptosporidium parvum, Giardia lamblia, and VEE...
  6. Pathophysiology of cholangiocyte responses to microbial pathogens
    STEVEN P O'HARA; Fiscal Year: 2013
    ..g. lipopolysaccharide) or colonized by pathogenic microorganisms (e.g. Cryptosporidium parvum, a parasitic protozoon and Category B Biodefense pathogen that causes intestinal and biliary ..
  7. IMPDH-targeted antibiotics for select agents
    LIZBETH K HEDSTROM; Fiscal Year: 2013
    ..in a medicinal chemistry program to develop IMPDH-targeted drugs for treating the category B parasite Cryptosporidium parvum. We have 'in hand'low nanomolar inhibitors of C...
  8. Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvum
    ARTHUR CLINTON WHITE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): New therapeutics are needed for infections caused by Cryptosporidium parvum and Toxoplasma gondii. Calcium dependent protein kinase 1 (CDPK1) of T...
  9. Mucosal Immunity and the Role of TH1 Cytokines in a Model of Cryptosporidiosis
    Jan R Mead; Fiscal Year: 2013
    ..are available for cryptosporidiosis among immunocompromised patients, which is an important concern since Cryptosporidium parvum infections in immunocompromised individuals often develop into chronic, severe cryptosporidiosis that can ..
  10. Novel approaches to develop a treatment for cryptosporidiosis
    Christopher D Huston; Fiscal Year: 2013
    ..provided by applicant): Cryptosporidiosis, due to intestinal infection with the intracellular parasites Cryptosporidium parvum or C...
  11. Targeting Host and Apicomplexan Isoprenoid Pathways
    Silvia N Moreno; Fiscal Year: 2013
    ..b>Cryptosporidium parvum is responsible for significant disease burden among children in developing countries and it can result in ..
  12. DESIGNING SELECTIVE INHIBITORS OF CALCIUM-DEPENDENT KINASES IN PARASITES
    L David Sibley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii and Cryptosporidium parvum are important opportunistic pathogens that cause devastating disease in immunocompromised humans...
  13. Apicomplexan Drug Target Discovery
    Ira J Blader; Fiscal Year: 2013
    ..Toxoplasma gondii, and Cryptosporidium parvum. Due to a lack of vaccines as well as continuously developing resistance and severe side-effects to ..
  14. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    Sherwood Gorbach; Fiscal Year: 2005
    ..and uninfected children living in rural South Africa, with a particular focus on infection with Cryptosporidium parvum and other protozoan pathogens...
  15. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    MICHAEL BENNISH; Fiscal Year: 2002
    ..and uninfected children living in rural South Africa, with a particular focus on infection with Cryptosporidium parvum and other protozoan pathogens...
  16. Mechanisms of Dinitroaniline Action, Selectivity and Resistance
    Naomi S Morrissette; Fiscal Year: 2010
    ..Leishmania spp., Entamoeba spp.,Plasmodium falcipamm, Cryptosporidium parvum and Toxoplasma gondii)...
  17. Evaluation of marketed drugs for rapid development as anti-cryptosporidal agents
    Guan Zhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cryptosporidium parvum is an AIDS-OI pathogen and Category B agent that can cause severe watery diarrhea in humans and animals...
  18. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2004
    ..of new drugs against Pneumocystis carinii (Pc), Toxoplasma gondii (Tg), Mycobacterium avium (My), and Cryptosporidium parvum (Cp), four opportunistic pathogens known to cause morbidity and mortality in AIDS patients...
  19. DICATIONIC DRUGS--TREATMENT FOR AIDS-RELATED INFECTIONS
    Richard Tidwell; Fiscal Year: 1999
    ..agents are needed for several other important AIDS related pathogens including: Cryptococcus neoformans, Cryptosporidium parvum, Mycobacterium avium, Toxoplasma gondii, Mycobacterium tuberculosis, and Candida albicans. Together with P...
  20. DRUG DISCOVERY AGAINST CRYPTOSPORIDIUM PARVUM
    JANET KEITHLY; Fiscal Year: 2003
    DESCRIPTION Cryptosporidium parvum causes one of the opportunistic infections (0I) in AIDS patients for which no treatment is yet known. Although many drugs have been tested against this 0I...
  21. PATHOGENESIS OF INTESTINAL CRYPTOSPORIDIOSIS IN AIDS
    Gerald Keusch; Fiscal Year: 1990
    b>Cryptosporidium parvum is the most common single infectious cause of diarrhea in AIDS patients (AIDS-associated diarrhea)...
  22. Cytoskeletal organization in apicomplexan parasites
    Heide Schatten; Fiscal Year: 2005
    ..Toxoplasma gondii, a model for harmful apicomplexan parasites that include Plasmodium falciparum and Cryptosporidium parvum. Despite the importance of the cytoskeleton for cell division in these unicellular organisms the ..
  23. INTESTINAL CYTOKINES IN CRYPTOSPORIDIOSIS
    A White; Fiscal Year: 2005
    DESCRIPTION (Provided by the applicant): Cryptosporidium parvum is a major cause of diarrhea worldwide, for which there is no reliable antiparasitic therapy. In immunocompetent individuals, C...
  24. DICATIONIC DRUGS--METABOLISM AND TOXICITY
    Richard Tidwell; Fiscal Year: 1993
    ..demonstrated activity against two other AIDS-related opportunistic pathogens; Toxoplasma gondii, and Cryptosporidium parvum. Although dicationic agents are accepted as important in the clinical management of the AIDS patient, this ..
  25. An Ecological Analysis of Cryptosporidium in Kenya
    Jeffrey Griffiths; Fiscal Year: 2004
    ..The WEDDS study is being conducted in Massachusetts, where exposure to Cryptosporidium parvum (CP) is moderate compared to developing world environments...
  26. In vitro refinements for Cryptosporidium parvum
    STEVE UPTON; Fiscal Year: 2003
    Over the last decade, our ability to cultivate the intestinal protozoan, Cryptosporidium parvum, in cell culture has increased by >500x...
  27. Development of a nucleic acid biosensor for Cryptosporidium Parvum
    GILLIAN VIMBAI KUPAKUWANA; Fiscal Year: 2010
    ..Development of a high throughput screening method that is much faster and more versatile than the existing methods, coupled with novel pyrosequencing technology will be key in the excution of the proposal's main objectives. ..
  28. POLYCLONAL ANTIBODY LIBRARIES FOR C PARVUM THERAPY
    Jacqueline Sharon; Fiscal Year: 1999
    ..a safe and effective drug for the treatment or prevention of opportunistic infection with the parasite Cryptosporidium parvum (C. parvum)...
  29. PRECLIN EVAL OF THERAPIES FOR CRYPTOSPORIDIUM PARVUM INF
    Saul Tzipori; Fiscal Year: 2000
    ..There is no reliable therapy or preventive agent for cryptosporidium parvum infection, regardless of immune status...
  30. CONTROL OF CRYPTOSPORIDIOSIS BY NEUTRALIZING ANTIBODIES
    LANCE PERRYMAN; Fiscal Year: 1992
    Cryptosporidiosis is a devastating disease in immunodeficient hosts caused by Cryptosporidium parvum, a sporozoan parasite that replicates in the epithelial cells of the intestinal and/or respiratory tract of man and other mammals...
  31. ANTIADHESIVE RECEPTOR MIMETICS FOR CRYPTOSPORIDIOSIS
    Mark Kuhlenschmidt; Fiscal Year: 2000
    b>Cryptosporidium parvum is a ubiquitous protozoan parasite that causes severe diarrheal disease in both humans and animals. This organism was recently responsible for the largest outbreak of waterborne disease in U. S. history...
  32. CARBOHYDRATE-BASED THERAPY FOR CRYPTOSPORIDIOSIS
    Honorine Ward; Fiscal Year: 1999
    b>Cryptosporidium parvum is a significant cause of diarrheal disease of human and veterinary importance worldwide. There is currently no effective, specific therapy approved for cryptosporidiosis...
  33. MODULATION OF IN VITRO CRYPTOSPORIDIUM PARVUM INFECTION
    Timothy Flanigan; Fiscal Year: 1993
    b>Cryptosporidium parvum is a coccidian parasite which causes severe diarrhea and malabsorption in patients with AIDS for which there is no effective therapy...
  34. DRUG DISCOVERY--POLYAMINE METABOLISM OF CRYPTOSPORIDIUM
    JANET KEITHLY; Fiscal Year: 1999
    There are many O1s in AIDS patients which cause debilitating diarrhea. Cryptosporidium parvum is one of these. The purpose of this application is to explore the polyamine pathway of C. parvum for its potential as a chemotherapeutic target...
  35. Host cell proteins that interact with Cryptosporidium
    Guan Zhu; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cryptosporidium parvum is a zoonotic pathogen and can cause one of the opportunistic infections in AIDS patients (AIDS-OI)...
  36. GENETIC DIVERSITY AND VIRULENCE OF CRYPTOSPORIDIUM
    Douglas Clark; Fiscal Year: 2001
    DESCRIPTION: (Adapted from Applicant's Abstract) Cryptosporidium parvum is an important, poorly-understood protozoan parasite that causes refractory intestinal infection in HIV-infected persons...
  37. Studies on Cryptosporidium parvum Type 1
    Saul Tzipori; Fiscal Year: 2006
    ..The goal of this project is a comprehensive characterization of Cryptosporidium parvum type 1, the most common agent of human cryptosporidiosis in the general population and in people with AIDS...
  38. Sequence variability of Cryptosporidium parvum virulence genes
    John McEvoy; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Cryptosporidium parvum is a primary cause of cryptosporidiosis, an infectious disease affecting humans, which can become chronic and life threatening in immunocompromised individuals...
  39. Localized Water Influx During Cryptosporidium Invasion
    STEVEN O HARA; Fiscal Year: 2009
    ..The current proposal focuses on the interactions between cholangiocytes and Cryptosporidium parvum, a coccidian parasite in the phylum Apicomplexathat has been associatedwith infection of the ..
  40. Carbohydrate-Based Therapy of Cryptosporidiosis
    Honorine Ward; Fiscal Year: 2002
    b>Cryptosporidium parvum is a significant cause of diarrheal disease of human and veterinary importance worldwide. There is currently no effective, specific therapy approved for cryptosporidiosis...
  41. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2001
    b>Cryptosporidium parvum (CP) causes prolonged and severe infections in humans with AIDS or mutated CD154 genes (X linked immunodeficiency with hyper IgM, or XHIM) with the development of sclerosing cholangitis and a need for liver ..
  42. STRAIN SPECIFICITY OF ANTI-CRYPTOSPORIDIUM IGG
    JOSEPH CRABB; Fiscal Year: 1992
    DESCRIPTION: (Adapted from the applicant's abstract) Cryptosporidium parvum is a significant human pathogen for which no chemotherapy has been shown to be efficacious...
  43. NEW BROAD SPECTRUM DRUGS FOR OPPORTUNISTIC INFECTIONS
    Lawrence Potempa; Fiscal Year: 2000
    ..to treat important AIDS-associated opportunistic pathogens, including the intestinal protozoan parasite Cryptosporidium parvum and the fungal pathogens Pneumocystis carinii, Candida albicans and Cryptococcus neoformans...
  44. IDENTIFYING CRYPTOSPORIDIUM PROTECTIVE ANTIGEN GENES
    JOSEPH CRABB; Fiscal Year: 1992
    b>Cryptosporidium parvum is a significant human pathogen whose incidence has increased dramatically in the last decade and that currently infects approximately 10% of the AIDS patients in the U.S...
  45. Innate Immune Recognition of Cryptosporidium parvum
    Honorine Ward; Fiscal Year: 2007
    ..The long-term goal is to determine whether specific molecules or pathways can be targeted to enhance innate immunity to the parasite or to prevent immunopathology induced by dysregulated innate immune responses. [unreadable] [unreadable]..
  46. Elucidation of Cryptosporidium virulence mechanisms using Toxoplasma gondii
    LAURA KNOLL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Toxoplasma gondii and Cryptosporidium parvum cause fatal infections in persons immune compromised by AIDS. For AIDS patients, there is essentially no effective therapy against C...
  47. Characterization of an AIDS-related Ol receptor, CSL-R
    REBECCA LANGER; Fiscal Year: 2005
    b>Cryptosporidium parvum, an opportunistic infection of AIDS patients, has become well recognized as a causative agent of persistent and life-threatening diarrhea for these individuals. Additionally, C...
  48. DSRNAS OF CRYPTOSPORIDIUM PARVUM
    STEVE UPTON; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Cryptosporidium parvum is a gastrointestinal parasite capable of causing moderate to severe diarrheal disease in both humans and animals...
  49. CRYPTOSPORIDIUM PARVUM GENOME SEQUENCING PROJECT
    Gregory Buck; Fiscal Year: 2003
    Description (Adapted from Applicant's abstract): Cryptosporidium parvum is an important causative agent of diarrhea in humans and animals worldwide...
  50. Dinitroaniline Specificity for Tubulin
    Naomi Morrissette; Fiscal Year: 2005
    ..Leishmania spp., Entamoeba spp., Plasmodium falciparum, Cryptosporidium parvum and Toxoplasma gondii...
  51. New Sensitive Detection of Food and Water Borne Pathogens
    JAY GEORGE; Fiscal Year: 2005
    ..E. coli O157:H7, Listeria monocytogenes, Salmonella enterica and Cryptosporidium parvum food and water borne pathogens are accountable for 1 million infections annually [1]...
  52. PATHOGENESIS OF HUMAN CRYTOSPORIDIOSIS
    CYNTHIA SEARS; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Cryptosporidium parvum is one of the leading parasitic causes of diarrhea in the United States and abroad...
  53. Molecular Basis of Cryptosporidium-Host cell Interaction
    Honorine Ward; Fiscal Year: 2007
    ..of this project is to further our understanding of the molecular basis of host-parasite interactions of Cryptosporidium parvum in order to develop specific preventive and therapeutic strategies for cryptosporidiosis. C...
  54. IMMUNOTHERAPY FOR CRYPTOSPORIDIUM INFECTIONS
    JOSEPH CRABB; Fiscal Year: 1990
    DESCRIPTION: (Adapted from the Applicant's Abstract) The number of cases of human diarrhea attributed to Cryptosporidium parvum has increased dramatically in the last decade...
  55. TRANSPORT PROPERTIES OF CRYPTOSPORIDIUM PARVUM CPABC
    SYLVIA LEBLANCQ; Fiscal Year: 2000
    b>Cryptosporidium parvum is an important opportunistic infection in persons with the acquired immunodeficiency syndrome (AIDS). C...
  56. IN VITRO STUDIES ON CRYPTOSPORIDIUM, AN OI OF AIDS
    STEVE UPTON; Fiscal Year: 1993
    b>Cryptosporidium parvum (Apicomplexa) has emerged as an important opportunistic pathogen of patients suffering from the Acquired Immunodeficiency Syndrome (AIDS)...
  57. IMMUNITY TO CRYPTOSPORIDIOSIS IN SIV INFECTED MACAQUES
    Saul Tzipori; Fiscal Year: 2002
    ..2A of this proposal will examine the T and B lymphocyte responses associate with resolution of an acute Cryptosporidium parvum infection in normal, immunocompetent macaques...
  58. MUCOSAL IMMUNE RESPONSES DURING CRYPTOSPORIDIOSIS
    CAROL WYATT; Fiscal Year: 2001
    b>Cryptosporidium parvum is a coccidian parasite that infects intestinal and extraintestinal mucosal epithelial cells in humans, cattle and other mammals. C...
  59. MUCOSAL IMMUNE RESPONSES IN CRYPTOSPORIDIOSIS
    F Enriquez; Fiscal Year: 1999
    b>Cryptosporidium parvum is an important gastrointestinal pathogen around the world. C. parvum causes severe diarrhea and not infrequently death among the immunologically naive and the immunocompromised, particularly AIDS patients...
  60. PROTEIN TARGETING TO THE TOXOPLASMA GONDII PLASTID
    Marilyn Parsons; Fiscal Year: 2000
    ..opportunistic infections in AIDS patients are those caused by two related parasites: Toxoplasma gondii and Cryptosporidium parvum. Both organisms belong to the phylum Apicomplexa, whose members (including the causative agent of malaria) ..
  61. INTERFERON GAMMA AND THE IMMUNE RESPONSE TO C PARVUM
    Cynthia Theodos; Fiscal Year: 2000
    ..Interferon gamma functions in the establishment of an acquired immune response to the coccidian parasite Cryptosporidium parvum. The hypotheses to be tested are that production of IFN-gamma during an immune response to C...
  62. C. PARVUM GLYCOPROTEINS: POTENTIAL TARGETS FOR THERAPY
    Honorine Ward; Fiscal Year: 2002
    ..and safe strategies for the treatment and prevention of opportunistic infection with the parasite Cryptosporidium parvum. This parasite is a significant cause of human gastrointestinal disease worldwide...