biomphalaria

Summary

Summary: A genus of planorbid freshwater snails, species of which are intermediate hosts of Schistosoma mansoni.

Top Publications

  1. ncbi An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions
    Yves Mone
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, 52 Ave Paul Alduy, 66860 Perpignan Cedex, France
    Int J Parasitol 41:721-30. 2011
  2. pmc The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011
  3. pmc Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei
    Patrick C Hanington
    Center for Theoretical and Evolutionary Immunology CETI, Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Int J Parasitol 40:819-31. 2010
  4. pmc Larval excretory-secretory products from the parasite Schistosoma mansoni modulate HSP70 protein expression in defence cells of its snail host, Biomphalaria glabrata
    Zahida Zahoor
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Cell Stress Chaperones 15:639-50. 2010
  5. pmc Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni
    Timothy P Yoshino
    Department of Pathobiological Sciences, School of Veterinary Medicine University, of Wisconsin, Madison, WI 53706, USA
    Gene 411:46-58. 2008
  6. pmc Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 107:21087-92. 2010
  7. pmc Successful parasitism of vector snail Biomphalaria glabrata by the human blood fluke (trematode) Schistosoma mansoni: a 2009 assessment
    Christopher J Bayne
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Mol Biochem Parasitol 165:8-18. 2009
  8. ncbi Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of adhesion genes
    A Bouchut
    Parasitologie Fonctionnelle et Evolutive, UMR 5555, CNRS Université de Perpignan, 52 Ave Paul Alduy, Perpignan Cedex 66860, France
    Int J Parasitol 36:175-84. 2006
  9. ncbi Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke, Schistosoma mansoni
    R J DeJong
    Department of Biology, University of New Mexico, Albuquerque 87131, USA
    Mol Biol Evol 18:2225-39. 2001
  10. pmc Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes)
    Coen M Adema
    Center for Evolutionary and Theoretical Immunology, Biology MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Mol Immunol 47:849-60. 2010

Detail Information

Publications286 found, 100 shown here

  1. ncbi An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions
    Yves Mone
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, 52 Ave Paul Alduy, 66860 Perpignan Cedex, France
    Int J Parasitol 41:721-30. 2011
    ..host-parasite model that allows co-evolution to be monitored in the field: the interaction between the mollusc, Biomphalaria glabrata, and its trematode parasite, Schistosoma mansoni...
  2. pmc The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011
    ..specific FReDs called fibrinogen-related proteins (FREPs) identified from the schistosome-transmitting mollusc Biomphalaria glabrata...
  3. pmc Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei
    Patrick C Hanington
    Center for Theoretical and Evolutionary Immunology CETI, Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Int J Parasitol 40:819-31. 2010
    ..a microarray designed to monitor the internal defense and stress-related responses of the freshwater snail Biomphalaria glabrata, we have undertaken a time course study to monitor snail responses following exposure to two different ..
  4. pmc Larval excretory-secretory products from the parasite Schistosoma mansoni modulate HSP70 protein expression in defence cells of its snail host, Biomphalaria glabrata
    Zahida Zahoor
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Cell Stress Chaperones 15:639-50. 2010
    ..mansoni on HSP70 protein expression levels in haemocytes (defence cells) from its snail intermediate host Biomphalaria glabrata. S. mansoni larval stage ESPs are known to interfere with haemocyte physiology and behaviour...
  5. pmc Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni
    Timothy P Yoshino
    Department of Pathobiological Sciences, School of Veterinary Medicine University, of Wisconsin, Madison, WI 53706, USA
    Gene 411:46-58. 2008
    ..type galectin was characterized from an embryonic cell line (Bge) and circulating hemocytes of the snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni. The predicted B...
  6. pmc Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 107:21087-92. 2010
    ..We have previously noted that the snail Biomphalaria glabrata produces a secreted lectin, fibrinogen-related protein 3 (FREP3), unusual among invertebrate defense ..
  7. pmc Successful parasitism of vector snail Biomphalaria glabrata by the human blood fluke (trematode) Schistosoma mansoni: a 2009 assessment
    Christopher J Bayne
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Mol Biochem Parasitol 165:8-18. 2009
    ..For one intermediate host snail (Biomphalaria glabrata) and trematodes for which it serves as vector, molecular genetic and proteomic surveys for genes and ..
  8. ncbi Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of adhesion genes
    A Bouchut
    Parasitologie Fonctionnelle et Evolutive, UMR 5555, CNRS Université de Perpignan, 52 Ave Paul Alduy, Perpignan Cedex 66860, France
    Int J Parasitol 36:175-84. 2006
    Because susceptibility or resistance of Biomphalaria glabrata to the trematode Echinostoma caproni correlates with differential hemocytic adhesive properties, we compared the expression of genes involved in adhesion processes between ..
  9. ncbi Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke, Schistosoma mansoni
    R J DeJong
    Department of Biology, University of New Mexico, Albuquerque 87131, USA
    Mol Biol Evol 18:2225-39. 2001
    ..parasite of humans, is determined by the occurrence of its intermediate hosts, freshwater snails of the genus Biomphalaria (Preston 1910)...
  10. pmc Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes)
    Coen M Adema
    Center for Evolutionary and Theoretical Immunology, Biology MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Mol Immunol 47:849-60. 2010
    ..emphasizes stress and immune responses factors was constructed to study transcriptomic responses of the snail Biomphalaria glabrata to different immune challenges...
  11. pmc Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni
    Anne E Lockyer
    Institute of Biological and Environmental Sciences, School of Biological Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen AB242TZ, UK
    BMC Genomics 9:634. 2008
    b>Biomphalaria glabrata is an intermediate snail host for Schistosoma mansoni, one of the important schistosomes infecting man. B. glabrata/S...
  12. ncbi Localization of carbohydrate determinants common to Biomphalaria glabrata as well as to sporocysts and miracidia of Schistosoma mansoni
    T Lehr
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Germany
    Parasitology 135:931-42. 2008
    The presence of antigenic carbohydrate epitopes shared by Biomphalaria glabrata as well as by the sporocysts and miracidia representing snail-pathogenic larval stages of Schistosoma mansoni was assayed by immunohistochemical staining of ..
  13. ncbi Schistosoma mansoni: In vitro schistosomicidal activity of piplartine
    Josué de Moraes
    Laboratorio de Parasitologia, Instituto Butantan, Sao Paulo, Brazil
    Exp Parasitol 127:357-64. 2011
    ..8-630.2 μM. At doses higher than 157.6 μM, piplartine induced morphological changes in the oral and ventral sucker regions of the worms. It is the first time that the schistosomicidal activity has been reported for piplartine...
  14. ncbi Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
    ..The next generation of schistosomiasis control can be optimized using new monitoring tools and effective transmission containment...
  15. ncbi Biomphalaria tenagophila: dominant character of the resistance to Schistosoma mansoni in descendants of crossbreedings between resistant (Taim, RS) and susceptible (Joinville, SC) strains
    Florence Mara Rosa
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 100:19-23. 2005
    ..parasitological, molecular, and genetic aspects in descendants of crossbreedings between a totally resistant Biomphalaria tenagophila strain (Taim, RS) and another one highly susceptible (Joinville, SC) to Schistosoma mansoni...
  16. ncbi Structural characterization of N-glycans from the freshwater snail Biomphalaria glabrata cross-reacting with Schistosoma mansoni glycoconjugates
    Tobias Lehr
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    Glycobiology 17:82-103. 2007
    The human parasitic trematode Schistosoma mansoni has a complex life cycle that includes the freshwater snail Biomphalaria glabrata as intermediate host...
  17. ncbi Comparative gene analysis of Biomphalaria glabrata hemocytes pre- and post-exposure to miracidia of Schistosoma mansoni
    Nithya Raghavan
    Biomedical Research Institute, Rockville, MD 20852, USA
    Mol Biochem Parasitol 126:181-91. 2003
    The internal defense mechanism of the snail Biomphalaria glabrata during a schistosome infection is activated and mediated via the immune effector cells known as hemocytes...
  18. ncbi Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite
    Ana Carolina Alves de Mattos
    Laboratorio de Esquistossomose, Instituto de Pesquisa René Rachou Fiocruz, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 106:424-32. 2011
    The outcome of the interaction between Biomphalaria and Schistosoma mansoni depends on the response of the host internal defence system (IDS) and the escape mechanisms of the parasite...
  19. pmc Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, MD 20852, USA
    Exp Parasitol 123:203-11. 2009
    ..RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse ..
  20. pmc Compatibility polymorphism in snail/schistosome interactions: From field to theory to molecular mechanisms
    G Mitta
    Universite de Perpignan Via Domitia, Perpignan F 66860, France
    Dev Comp Immunol 37:1-8. 2012
    ..The mechanisms underlying compatibility have remained largely unknown in the interactions between the snail Biomphalaria glabrata and Schistosoma mansoni, one of the agents of human schistosomiasis...
  21. pmc Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, MD 20852, USA
    Mol Biochem Parasitol 169:27-39. 2010
    Resistance or susceptibility of the snail host Biomphalaria glabrata to Schistosoma mansoni is determined by the genetics of both the snail and parasite...
  22. ncbi Differential expression of LacdiNAc, fucosylated LacdiNAc, and Lewis x glycan antigens in intramolluscan stages of Schistosoma mansoni
    A Kwame Nyame
    Department of Biochemistry and Molecular Biology, The Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Parasitol 88:890-7. 2002
    ..mansoni, these results show that LDN and LDNF glycans are conserved during schistosome development. The study further extends the evidence that Le(x) is a developmentally regulated antigen in schistosomes...
  23. ncbi Transmission control of schistosomiasis mansoni by introduction of a resistant strain of Biomphalaria tenagophila in areas where transmission is maintained by this species
    Paulo Marcos Zech Coelho
    Centro de Pesquisas René Rachou CPqRR FIOCRUZ, Avenue Augusto de Lima1 1715, 31190 002 Belo Horizonte, Minas Gerais, Brazil
    Acta Trop 108:245-8. 2008
    b>Biomphalaria tenagophila Taim lineage has proved to be consistently resistant to Schistosoma mansoni...
  24. pmc Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata
    Matty Knight
    Biomedical Research Institute, Rockville, Maryland, USA
    PLoS Negl Trop Dis 5:e1212. 2011
    An in vivo, non-invasive technique for gene silencing by RNA interference (RNAi) in the snail, Biomphalaria glabrata, has been developed using cationic polymer polyethyleneimine (PEI) mediated delivery of long double-stranded (ds) and ..
  25. ncbi Effect of Angiostrongylus vasorum infection on Biomphalaria tenagophila susceptibility to Schistosoma mansoni
    C A J Pereira
    Departamento de Parasitologia, Instituto de Ciencias Biologicas ICB, Universidade Federal de Minas Gerais UFMG, Av Presidente Antônio Carlos 6627, Campus Pampulha, 31270 901 Belo Horizonte MG, Brazil
    Acta Trop 98:224-33. 2006
    ..However, when S. mansoni infection occurred after A. vasorum larvae are completely encapsulated, the response against S. mansoni was not altered, and therefore there were no differences in the susceptibility level...
  26. ncbi N-Glycosylation patterns of hemolymph glycoproteins from Biomphalaria glabrata strains expressing different susceptibility to Schistosoma mansoni infection
    Tobias Lehr
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Giessen, Germany
    Exp Parasitol 126:592-602. 2010
    Comparative analyses of the N-glycosylation pattern of hemolymph glycoproteins from Biomphalaria glabrata strains Puerto Rico (BgPR) and Salvador (BgBS-90), differing in their susceptibility towards Schistosoma mansoni infection, were ..
  27. ncbi Adaptive responses and latent costs of multigeneration cadmium exposure in parasite resistant and susceptible strains of a freshwater snail
    Christopher J Salice
    The Institute of Environmental and Human Health, Texas Tech University, Box 41163, Lubbock, TX 79409 1163, USA
    Ecotoxicology 19:1466-75. 2010
    ..We tested how parasite-resistant and -susceptible strains of the freshwater snail, Biomphalaria glabrata, responded to cadmium and elevated temperature challenges after having been exposed to low-level ..
  28. ncbi Biomphalaria tenagophila/Schistosoma mansoni interaction: premises for a new approach to biological control of schistosomiasis
    P M Z Coelho
    Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715, 30190 002 Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 99:109-11. 2004
    b>Biomphalaria tenagophila is very important for schistosomiasis transmission in Brazil. However its mechanisms of interaction with Schistosoma mansoni are still scantly studied...
  29. pmc Nimbus (BgI): an active non-LTR retrotransposon of the Schistosoma mansoni snail host Biomphalaria glabrata
    Nithya Raghavan
    Biomedical Research Institute BRI, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Int J Parasitol 37:1307-18. 2007
    The freshwater snail Biomphalaria glabrata is closely associated with the transmission of human schistosomiasis...
  30. ncbi Resistance to Schistosoma mansoni by transplantation of APO Biomphalaria tenagophila
    L Barbosa
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Parasite Immunol 28:209-12. 2006
    Transplantation of the haematopoietic organ from Biomphalaria tenagophila (Taim strain, RS, Brazil), resistant to Schistosoma mansoni, to a highly susceptible strain (Cabo Frio, RJ, Brazil) of the same species, showed in the recipient ..
  31. pmc Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study
    Emeline Deleury
    INRA CNRS UNS, Institut Sophia Agrobiotech, Sophia Antipolis, France
    PLoS ONE 7:e32512. 2012
    ..To investigate the global specificity of the immune response in the fresh-water snail Biomphalaria glabrata, we used massive Illumina sequencing of 5'-end cDNAs to compare expression profiles after challenge by ..
  32. ncbi Occurrence of Biomphalaria cousini (Mollusca: Gastropoda) in Brazil and its susceptibility to Schistosoma mansoni (Platyhelminths: Trematoda)
    Tatiana Maria Teodoro
    Laboratório de Helmintologia e Malacologia Médica, Centro de Pesquisas Rene Rachou Fiocruz, Belo Horizonte, Minas Gerais, Brazil
    Mol Phylogenet Evol 57:144-51. 2010
    ..cousini. Furthermore, B. cousini showed to be susceptible to S. mansoni. These results confirm the occurrence of B. cousini in Brazil and points to the risk of introduction of schistosomiasis mansoni into new areas...
  33. pmc Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation
    Matty Knight
    Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Mol Biochem Parasitol 167:20-31. 2009
    To identify gene(s) that may be associated with resistance/susceptibility in the intermediate snail host Biomphalaria glabrata to Schistosoma mansoni infection, a snail albumen gland cDNA library was differentially screened and a partial ..
  34. ncbi Participation of cell-free haemolymph of Biomphalaria tenagophila in the defence mechanism against Schistosoma mansoni sporocysts
    C A J Pereira
    Departamento de Parasitologia, ICB, UFMG, Belo Horizonte, MG, Brazil
    Parasite Immunol 30:610-9. 2008
    b>Biomphalaria tenagophila of Taim strain is able to completely destroy Schistosoma mansoni sporocyst few hours after parasite penetration, although the mechanism is still not well known...
  35. ncbi Molluscicidal and ovicidal activities of plant extracts of the Piperaceae on Biomphalaria glabrata (Say, 1818)
    L N Rapado
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    J Helminthol 85:66-72. 2011
    ..disease is application of molluscicides to eliminate or to reduce the population of the intermediate host snail Biomphalaria glabrata...
  36. ncbi Parasite-susceptibility phenotypes of F1 Biomphalaria glabrataprogeny derived from interbreeding Schistosoma mansoni-resistant and -susceptible snails
    Fred A Lewis
    Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Parasitol Res 89:98-101. 2003
    ..Five parental populations of Biomphalaria glabrata were used to generate the progeny snails...
  37. pmc Effects of intermediate host genetic background on parasite transmission dynamics: a case study using Schistosoma mansoni
    Monika Zavodna
    Department of Biological Sciences, Purdue University, West Lafayette, IN, USA
    Exp Parasitol 120:57-61. 2008
    ..We performed experimental Schistosoma mansoni infections utilizing two allopatric populations of Biomphalaria glabrata snails and assessed intensities and sex ratios of adult parasites in mouse definitive hosts...
  38. pmc Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni
    Matty Knight
    Biomedical Research Institute, 12111 Parklawn Dr Rockville, MD 20852, USA
    Int J Parasitol 41:61-70. 2011
    b>Biomphalaria glabrata is a major intermediate host for the parasitic trematode Schistosoma mansoni, a causative agent of human schistosomiasis...
  39. pmc Expression profiling and binding properties of fibrinogen-related proteins (FREPs), plasma proteins from the schistosome snail host Biomphalaria glabrata
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, New Mexico 97131, USA
    Innate Immun 14:175-89. 2008
    ..It has been shown that fibrinogen-related proteins (FREPs), plasma proteins present in the freshwater snail Biomphalaria glabrata, the intermediate host for the human blood fluke Schistosoma mansoni, are diverse and involved in ..
  40. pmc Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata)
    Emmanuel Roger
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, Perpignan, France
    PLoS Negl Trop Dis 2:e330. 2008
    ..g. in echinoderms, insects and mollusks (Biomphalaria glabrata))...
  41. pmc Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobin
    Bernhard Lieb
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    Proc Natl Acad Sci U S A 103:12011-6. 2006
    ..here the complete cDNA and predicted amino acid sequence of two hemoglobin polypeptides from the planorbid Biomphalaria glabrata (intermediate host snail for the human parasite Schistosoma mansoni)...
  42. ncbi Larval Schistosoma mansoni excretory-secretory glycoproteins (ESPs) bind to hemocytes of Biomphalaria glabrata (Gastropoda) via surface carbohydrate binding receptors
    L A Johnston
    Department of Pathobiological Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 53706, USA
    J Parasitol 87:786-93. 2001
    Flow cytometric analysis of circulating blood cells (hemocytes) of Biomphalaria glabrata, molluscan intermediate host of Schistosoma mansoni, revealed the presence of 2 overlapping hemocyte subpopulations, designated R1 and R2...
  43. ncbi Identification and expression of gene transcripts generated during an anti-parasitic response in Biomphalaria glabrata
    François Guillou
    Parasitologie Fonctionnelle et Evolutive, UMR 5555, CNRS Université de Perpignan, Perpignan, France
    Dev Comp Immunol 31:657-71. 2007
    ..insights into the molecular basis of gastropod anti-parasite immune responses, we investigated transcripts of Biomphalaria glabrata regulated during hemocytic encapsulation...
  44. ncbi Schistosoma mansoni and Echinostoma caproni excretory-secretory products differentially affect gene expression in Biomphalaria glabrata embryonic cells
    C Coustau
    Parasitologie Fonctionnelle et Evolutive, UMR CNRS 5555, 52 Avenue Paul Alduy, Universite de Perpignan, 66860 Perpignan Cedex, France
    Parasitology 127:533-42. 2003
    b>Biomphalaria glabrata embryonic (Bge) cells have been shown to be a valuable in vitro cellular model for the study of snail host-parasite interactions...
  45. ncbi Diversification of Ig superfamily genes in an invertebrate
    Si Ming Zhang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Science 305:251-4. 2004
    The freshwater snail Biomphalaria glabrata possesses a diverse family of fibrinogen-related proteins (FREPs), hemolymph polypeptides that consist of one or two amino-terminal immunoglobulin superfamily (IgSF) domains and a carboxyl-..
  46. pmc Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni
    Alvaro Baeza Garcia
    Institut Pasteur de Lille, CIIL, Lille, France INSERM, U 1019, Lille, France Univ Lille Nord de France, Lille, France CNRS, UMR 8204, Lille, France
    PLoS Pathog 6:e1001115. 2010
    ..characterized a Macrophage Migration Inhibitory Factor (MIF) family member in the Lophotrochozoan invertebrate, Biomphalaria glabrata, the snail intermediate host of the human blood fluke Schistosoma mansoni...
  47. ncbi The major soluble 19.6 kDa protein of the organic shell matrix of the freshwater snail Biomphalaria glabrata is an N-glycosylated dermatopontin
    Julia C Marxen
    Zoologisches Institut und Museum der Universität Hamburg, D 20146 Hamburg, Germany
    Biochim Biophys Acta 1650:92-8. 2003
    The major Biomphalaria glabrata shell matrix protein of 19.6 kDa was isolated by preparative electrophoresis and sequenced...
  48. ncbi Characterisation of proteins differentially present in the plasma of Biomphalaria glabrata susceptible or resistant to Echinostoma caproni
    D Vergote
    Neuro immunologie des Annélides, UMR 8017, CNRS Université des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Int J Parasitol 35:215-24. 2005
    ..As an approach to further investigate the suspected involvement of plasmatic factors in Biomphalaria glabrata resistance/susceptibility to Echinostoma caproni, we compared protein patterns of plasma collected ..
  49. ncbi Surface membrane proteins of Biomphalaria glabrata embryonic cells bind fucosyl determinants on the tegumental surface of Schistosoma mansoni primary sporocysts
    Maria G Castillo
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2115 Observatory Drive, Madison, Wisconsin, USA
    J Parasitol 93:832-40. 2007
    Previous observations that in vitro adherence of Biomphalaria glabrata embryonic (Bge) cells to sporocyst larval stages of Schistosoma mansoni was strongly inhibited by fucoidan, a sulfated polymer of L-fucose, suggested a role for ..
  50. ncbi Manganese superoxide dismutase from Biomphalaria glabrata
    Younghun Jung
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Invertebr Pathol 90:59-63. 2005
    The investigation of the response of Biomphalaria glabrata snails to Echinostoma paraensei (digenea) at 2 days post-exposure by suppression subtractive hybridization yielded a partial sequence of the anti-oxidant enzyme manganese ..
  51. ncbi Recombinant functional multidomain hemoglobin from the gastropod Biomphalaria glabrata
    Vanessa Moeller
    Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
    IUBMB Life 63:323-8. 2011
    The extracellular hemoglobin multimer of the planorbid snail Biomphalaria glabrata, intermediate host of the human parasite Schistosoma mansoni, is presumed to be a 1...
  52. ncbi The compatibiuty polymorphism in invertebrate host/trematodes interactions: research of molecular determinants
    A Bouchut
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, France
    Parasite 15:304-9. 2008
    ..These comparisons led to the identification of numerous candidate genes listed and discussed (some of them) in the present review...
  53. ncbi Altered behavior of the snail Biomphalaria glabrata as a result of infection with Schistosoma mansoni
    Jérôme Boissier
    Centre de Biologie et d Ecologie Tropicale et Mediterraneenne, UMR 5555 CNRS UP, Universite de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France
    J Parasitol 89:429-33. 2003
    ..comparative behavioral study, the effect of infection with Schistosoma mansoni on its snail intermediate host Biomphalaria glabrata was investigated...
  54. ncbi Differential expression of FREP genes in two strains of Biomphalaria glabrata following exposure to the digenetic trematodes Schistosoma mansoni and Echinostoma paraensei
    Lynn A Hertel
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Dev Comp Immunol 29:295-303. 2005
    Fibrinogen-related proteins (FREPs) are hypothesized to function in non-self-recognition in the snail Biomphalaria glabrata...
  55. ncbi A molecular survey of biomphalaria in Egypt: is B. glabrata present?
    Wael M Lotfy
    Parasitology Department, Medical Research Institute, El Hadara, Alexandria, Egypt
    Am J Trop Med Hyg 73:131-9. 2005
    Two species of Biomphalaria are reported from Egypt, the indigenous Biomphalaria alexandrina and Biomphalaria glabrata, the latter believed to be introduced during the past few decades...
  56. ncbi Effect of crude lipopolysaccharide from Escherichia coli O127:B8 on the amebocyte-producing organ of Biomphalaria glabrata (Mollusca)
    John T Sullivan
    Department of Biology, University of San Francisco, San Francisco, CA 94117, USA
    Dev Comp Immunol 35:1182-5. 2011
    ..We measured the mitotic response of the hematopoietic tissue of the schistosome-transmitting snail, Biomphalaria glabrata, to crude LPS from Escherichia coli 0127:B8...
  57. ncbi A comparative parasitologic study on Biomphalaria glabrata snail and C3H/He mice infected with human and murine isolates of Schistosoma mansoni derived from Sumidouro, Rio de Janeiro, Brazil
    Nilcéa Freire
    Laboratório de Helmintologia Romero Lascasas Porto, Departamento de Patologia e Laboratorios, Faculdade de Ciencias Medicas, UERJ, 20550 031 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 98:783-7. 2003
    ..Sympatric reared-laboratory Biomphalaria glabrata and C3H/He mice were used as experimental hosts...
  58. ncbi Inheritance of Schistosoma mansoni infection incompatibility in Biomphalaria alexandrina snails
    Iman F Abou El Naga
    Department of Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Mem Inst Oswaldo Cruz 105:149-54. 2010
    ..of susceptibility and resistance to Schistosoma mansoni infection in the first generation of crossbred Biomphalaria alexandrina snails...
  59. ncbi Distribution and habitat preferences of the genus Biomphalaria (Gastropoda: Planorbidae) in Cuba
    Antonio Alejandro Vázquez Perera
    Laboratory of Malacology, Institute Pedro Kouri, Havana, Cuba
    Mem Inst Oswaldo Cruz 105:41-4. 2010
    A study was carried out to determine the distribution and habitat preferences of several species of the genus Biomphalaria. Samples were taken at 350 freshwater locations in Cuba...
  60. ncbi Differential lectin labelling of circulating hemocytes from Biomphalaria glabrata and Biomphalaria tenagophila resistant or susceptible to Schistosoma mansoni infection
    R L Martins-Souza
    Departamento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horzonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:185-92. 2006
    Lectins/carbohydrate binding can be involved in the Schistosoma mansoni recognition and activation of the Biomphalaria hemocytes...
  61. ncbi Primary culture of the region of the amebocyte-producing organ of the snail Biomphalaria glabrata, the intermediate host of Schistosoma mansoni
    L Barbosa
    Departmento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:639-43. 2006
    b>Biomphalaria glabrata snails are major hosts for the digenetic trematoda Schistosoma mansoni, the causative agent of human schistosomiasis...
  62. ncbi Influence of Echinostoma paraensei (Lie and Basch, 1967) infection on the calcium content in Biomphalaria glabrata (Say, 1818)
    Victor Menezes Tunholi
    Curso de Pós Graduação em Ciências Veterinárias, Departamento de Parasitologia Animal, Instituto de Veterinaria, Universidade Federal Rural do Rio de Janeiro, km7, BR 465, Antiga estrada Rio São Paulo, 23890 000 Seropédica, RJ, Brazil
    Exp Parasitol 129:266-9. 2011
    The calcium content in the hemolymph and shell of Biomphalaria glabrata (Say, 1818) was determined after exposure to different parasite burdens (5 and 50 miracidia) of Echinostoma paraensei (Lie and Basch, 1967)...
  63. ncbi Genetic differences between strains of Biomphalaria glabrata (Planorbidae) that are susceptible and unsusceptible to schistosomiasis
    A L D Oliveira
    Interunidades em Biotecnologia, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Genet Mol Res 9:1450-9. 2010
    ..Within this context, analysis of the genetic variability of intermediate host snails (Biomphalaria spp) is important because it allows identification of specific sequences of the genome of this mollusk related ..
  64. ncbi Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system
    Carine Machado Azevedo
    Laboratorio de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz FIOCRUZ, Rua Valdemar Falcão 121, 40295 001 Salvador, BA, Brazil
    Mem Inst Oswaldo Cruz 101:199-203. 2006
    b>Biomphalaria glabrata can react through different pathways to Schistosoma mansoni miracidium penetration, according to the degree of resistance/susceptibility presented by different snail strains, which is a genetically determined ..
  65. ncbi Involvement of protein kinase C signalling and mitogen-activated protein kinase in the amebocyte-producing organ of Biomphalaria glabrata (Mollusca)
    Zahra Salamat
    Department of Biology, University of San Francisco, San Francisco, CA 94117, USA
    Dev Comp Immunol 33:725-7. 2009
    ..study, 24-h saline cultures of the amebocyte-producing organ (APO) of the schistosome-transmitting snail Biomphalaria glabrata were used to test for the potential involvement of protein kinase C (PKC) signalling in hematopoiesis...
  66. pmc Reversing the resistance phenotype of the Biomphalaria glabrata snail host Schistosoma mansoni infection by temperature modulation
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, Maryland, United States of America
    PLoS Pathog 8:e1002677. 2012
    b>Biomphalaria glabrata snails that display either resistant or susceptible phenotypes to the parasitic trematode, Schistosoma mansoni provide an invaluable resource towards elucidating the molecular basis of the snail-host/schistosome ..
  67. ncbi Dominant character of the molecular marker of a Biomphalaria tenagophila strain (Mollusca: Planorbidae) resistant to Schistosoma mansoni
    Florence Mara Rosa
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, UFMG, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 99:85-7. 2004
    b>Biomphalaria tenagophila population from Taim (state of Rio Grande do Sul, Brazil) is totally resistant to Schistosoma mansoni, and presents a molecular marker of 350 bp by polymerase chain reaction and restriction fragment length ..
  68. ncbi Biomphalaria species in Alexandria water channels
    Iman F Abou-El-Naga
    Medical Parasitology Department, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
    Parasitol Int 60:247-54. 2011
    Of the several species of Biomphalaria snails worldwide that serve as the intermediate host for Schistosoma mansoni, Biomphalaria alexandrina is a species that is indigenous to Egypt...
  69. pmc Fibrinogen-bearing protein genes in the snail Biomphalaria glabrata: characterization of two novel genes and expression studies during ontogenesis and trematode infection
    Si Ming Zhang
    Department of Biology, University of New Mexico, MSC03 2020, Albuquerque, NM 87131, USA
    Dev Comp Immunol 32:1119-30. 2008
    All fibrinogen (FBG)-bearing proteins documented to date in the freshwater snail Biomphalaria glabrata, the intermediate host of the human blood fluke Schistosoma mansoni, possess the same molecular structure; one or two immunoglobin ..
  70. ncbi Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos
    Eduardo C Oliveira-Filho
    Laboratory of Environmental Toxicology, Department of Biological Sciences, National School of Public Health, FIOCRUZ, Rio de Janeiro, RJ 21040 361, Brazil
    Chemosphere 81:218-27. 2010
    ..b>Biomphalaria glabrata egg masses (0-15 h after spawning) were exposed to molluscicides for 96 h and thereafter examined up ..
  71. ncbi Compatibility of Biomphalaria tenagophila with Schistosoma mansoni: a study of homologous plasma transference
    João R Coelho
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Odontologia e Enfermagem, Universidade Federal do Ceara, 60430 370 Fortaleza, CE, Brazil
    Mem Inst Oswaldo Cruz 101:111-2. 2006
    This study aims to investigate the importance of the serum factors present in the plasma of resistant Biomphalaria tenagophila snails, when transferred to susceptible conspecific. Susceptible B...
  72. ncbi Fingerprint of Biomphalaria arabica, the intermediate host of Schistosoma mansoni in Saudi Arabia, using RAPD-PCR
    Saad M Bin Dajem
    Biology Department, Faculty of Science, King Khaled University, Abha, P O Box 9004, Saudi Arabia
    Gene 485:69-72. 2011
    ..We investigated Biomphalaria arabica, which is found in Saudi Arabia, the intermediate host of Schistosoma mansoni infection...
  73. ncbi Defense response of susceptible and resistant Biomphalaria alexandrina snails against Schistosoma mansoni infection
    Iman F Abou-El-Naga
    Medical Parasitology Department, Faculty of Medicine, Alexandria University, Egypt
    Rev Biol Trop 60:1195-204. 2012
    In Egypt, Biomphalaria alexandrina is the intermediate host for Schistosoma mansoni. The fates of Schistosoma miracidia in the snails varies between different species of Biomphalaria...
  74. ncbi High performance column liquid chromatographic analysis of selected carboxylic acids in Biomphalaria glabrata patently infected with Schistosoma mansoni
    Daniel R Massa
    Department of Chemistry, Lafayette College, Easton, PA 18042, USA
    Parasitol Res 101:925-8. 2007
    ..mansoni infection on certain carboxylic acids in the digestive gland gonad complex (DGG) and hemolymph of Biomphalaria glabrata...
  75. ncbi Laboratory assessment of the molluscicidal activity of Commiphora molmol (Myrrh) on Biomphalaria alexandrina, Bulinus truncatus and Lymnaea cailliaudi
    A F Allam
    Department of Parasitology, Medical Research Institute, Alexandria University, Egypt
    J Egypt Soc Parasitol 31:683-90. 2001
    ..properties of the oil extract of Commiphora molmol (Myrrh) were tested against Egyptian snail species: Biomphalaria alexandrina, Bulinus truncatus and Limnaea cailliaudi. The impact of the extract on the egg cluches of B...
  76. ncbi Spatial distribution of Biomphalaria mollusks at São Francisco River Basin, Minas Gerais, Brazil, using geostatistical procedures
    Ricardo J P S Guimarães
    Centro de Pesquisas René Rachou FIOCRUZ MG, Av Augusto de Lima 1715, Barro Preto, Belo Horizonte MG, Brazil
    Acta Trop 109:181-6. 2009
    Geostatistics is used in this work to make inferences about the presence of the species of Biomphalaria (B. glabrata, B. tenagophila and/or B...
  77. ncbi Geographical distribution of Biomphalaria snails in the State of Minas Gerais, Brazil
    C P Souza
    Laboratorio de Malacologia, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
    Mem Inst Oswaldo Cruz 96:293-302. 2001
    Published and unpublished observations on geographical distribution of Biomphalaria snails in the State of Minas Gerais, Brazil, were compiled...
  78. ncbi Resistance to cadmium and parasite infection are inversely related in two strains of a freshwater gastropod
    Christopher J Salice
    University of Maryland Center for Environmental Science, Chesapeake Biological Laboratory, Solomons 20688, USA
    Environ Toxicol Chem 21:1398-403. 2002
    ..susceptible to infection by the trematode parasite Schistosoma mansoni exist in the tropical freshwater snail Biomphalaria glabrata. We tested the hypothesis that a cost of parasite resistance in B...
  79. ncbi Seasonality in the transmission of schistosomiasis and in populations of its snail intermediate hosts in and around a sugar irrigation scheme at Richard Toll, Senegal
    R F Sturrock
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Parasitology 123:S77-89. 2001
    ..Populations of both Biomphalaria pfeifferi (the intermediate host of S. mansoni) and Bulinus spp. (mainly B. truncatus, the local host of S...
  80. ncbi Male-female larval interactions in Schistosoma mansoni-infected Biomphalaria glabrata
    J Boissier
    , , 52 Avenue de Villeneuve, 66860 Perpignan Cedex, France
    Int J Parasitol 31:352-8. 2001
    This paper investigates Schistosoma mansoni male-female larval interactions in simultaneous bi-miracidial Biomphalaria glabrata infections...
  81. pmc Characterization of immune genes from the schistosome host snail Biomphalaria glabrata that encode peptidoglycan recognition proteins and gram-negative bacteria binding protein
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131, USA
    Immunogenetics 59:883-98. 2007
    ..In this paper, we report four full-length PGRP cDNAs and one full-length GNBP cDNA cloned from the snail Biomphalaria glabrata, the intermediate host of the human blood fluke Schistosoma mansoni, designated as BgPGRPs and BgGNBP, ..
  82. ncbi Use of individual polymorphism to validate potential functional markers: case of a candidate lectin (BgSel) differentially expressed in susceptible and resistant strains of Biomphalaria glabrata
    F Guillou
    Parasitologie Fonctionnelle et Evolutive, UMR CNRS 5555, 52 Avenue Paul Alduy, Universite de Perpignan, 66860 Perpignan Cedex, France
    Comp Biochem Physiol B Biochem Mol Biol 138:175-81. 2004
    BgSel has been identified in Biomphalaria glabrata as a candidate adhesion molecule exhibiting both an Ig-like domain and a carbohydrate recognition domain showing similarities with the l domain of C-type lectins...
  83. ncbi Characterization of the mannose 6-phosphate receptor (Mr 300 kDa) protein dependent pathway of lysosomal enzyme targeting in Biomphalaria glabrata mollusc cells
    Praveen Kumar Amancha
    Department of Biochemistry, University of Hyderabad, India
    Biochimie 91:982-8. 2009
    ..The present study describes for the first time the MPR 300 dependent pathway of lysosomal enzyme sorting in the Biomphalaria glabrata embryonic (Bge) cells...
  84. pmc Carboxylic acids as biomarkers of Biomphalaria alexandrina snails infected with Schistosoma mansoni
    Salwa M F Abou Elseoud
    Parasitology Department, Ain Shams University, Cairo, Egypt
    Korean J Parasitol 48:127-32. 2010
    b>Biomphalaria alexandrina snails play an indispensable role in transmission of schistosomiasis...
  85. ncbi Biomphalaria tenagophila: dynamics of populations of resistant and susceptible strains to Schistosoma mansoni, with or without pressure of the parasite
    Florence Mara Rosa
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horzonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:247-51. 2006
    Resistant (Taim, RS) and susceptible albino (Joinville, SC) Biomphalaria tenagophila populations were kept together, at different proportions, throughout a 18-month-period...
  86. ncbi Evolutionary history and phylogeography of the schistosome-vector freshwater snail Biomphalaria glabrata based on nuclear and mitochondrial DNA sequences
    J Mavarez
    Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
    Heredity (Edinb) 89:266-72. 2002
    The phylogeography of the freshwater snail Biomphalaria glabrata remains poorly known, although this species is the major vector of schistosomiasis in the New World...
  87. ncbi Analysis of the first and second internal transcribed spacer sequences of the ribosomal DNA in Biomphalaria tenagophila complex (Mollusca: Planorbidae)
    Teofânia H D A Vidigal
    Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima, 1715, 30190 002 Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 99:153-8. 2004
    The first and second internal transcribed spacer regions (ITS1 and ITS2) of the ribosomal DNA of Biomphalaria tenagophila complex (B. tenagophila, B. occidentalis, and B. t. guaibensis) were sequenced and compared...
  88. ncbi Population-level responses to long-term cadmium exposure in two strains of the freshwater gastropod Biomphalaria glabrata: results from a life-table response experiment
    Christopher J Salice
    University of Maryland Center for Environmental Science, Chesapeake Biological Laboratory, P O Box 38, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 22:678-88. 2003
    ..demographic effects of low-level cadmium exposure on two strains, BS90 and NMRI, of the freshwater gastropod Biomphalaria glabrata. Snails were exposed to cadmium continuously from the embryonic stage through adulthood...
  89. ncbi Molecular characterisation of intermediate snail hosts and the search for resistance genes
    D Rollinson
    Natural History Museum, London, UK
    Mem Inst Oswaldo Cruz 93:111-6. 1998
    ..Snails resistant to infection occur naturally and there is a genetic basis for this resistance. In Biomphalaria glabrata resistance to Schistosoma mansoni is known to be a polygenic trait and we have initiated a preliminary ..
  90. ncbi Energy allocation patterns in Biomphalaria alexandrina snails in response to cadmium exposure and Schistosoma mansoni infection
    Mohamed Moussa Ibrahim
    Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
    Exp Parasitol 112:31-6. 2006
    ..the effects of both parasitism and environmental stress on the growth, reproduction, and survival of Biomphalaria alexandrina snails. Resource allocation strategies may be influenced by both biotic and abiotic factors...
  91. ncbi The relationship between Schistosoma mansoni and Biomphalaria glabrata: genetic and molecular approaches
    F A Lewis
    Biomedical Research Institute, Rockville, MD 20852, USA
    Parasitology 123:S169-79. 2001
    b>Biomphalaria glabrata is a major intermediate host for the helminth parasite Schistosoma mansoni...
  92. ncbi Alterations in hemolymph components in Biomphalaria glabrata during long-term infection with Schistosoma mansoni
    H Rupprecht
    Zoologisches Institut, , Federal Republic of Germany
    Parasitol Res 75:233-7. 1989
    Total protein, hemoglobin, glucose, and urea concentrations in hemolymph of Biomphalaria glabrata were studied during a 12-week infection of the snails with Schistosoma mansoni...
  93. ncbi Characterization of surface lectins binding and SDS-PAGE protein patterns of Biomphalaria alexandrina haemocytes infected with Schistosoma mansoni
    Azza H Mohamed
    Department of Zoology, Faculty of Science, Menoufia University, Shebin El Kom, Egypt
    J Egypt Soc Parasitol 35:615-30. 2005
    ..were tested with fluorescein labeled Avidin D for binding to haemocyte surfaces of non-inflected and infected Biomphalaria alexandrina snails with Schistosoma mansoi at 24 to 72 hours post infection (PI)...
  94. ncbi Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni
    Karlos A L Ribeiro
    Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Alagoas, Brazil
    Acta Trop 111:44-50. 2009
    Larvicidal (against Aedes aegypti Linnaeus, 1762) and molluscicidal (against Biomphalaria glabrata Say, 1818) activities of several natural and synthetic naphthoquinones were measured, with significant results...
  95. ncbi Thin layer chromatographic analysis of glucose and maltose in estivated Biomphalaria glabrata snails and those infected with Schistosoma mansoni
    Jamie A Jarusiewicz
    Department of Chemistry, Lafayette College, Easton, PA 18042, USA
    Comp Biochem Physiol B Biochem Mol Biol 145:346-9. 2006
    ..the glucose and maltose concentrations of the digestive gland-gonad complex (DGG) of uninfected-estivated Biomphalaria glabrata snails and estivated B. glabrata patently infected with Schistosoma mansoni...
  96. pmc Glycotope analysis in miracidia and primary sporocysts of Schistosoma mansoni: differential expression during the miracidium-to-sporocyst transformation
    Nathan A Peterson
    Department of Pathobiological Sciences, University of Wisconsin Madison, School of Veterinary Medicine, 2115 Observatory Drive, Madison, WI 53706, USA
    Int J Parasitol 39:1331-44. 2009
    ..Additionally, sharing of specific larval glycotopes with Biomphalaria glabrata suggests an evolutionary convergence of carbohydrate expression between schistosomes and their snail ..
  97. ncbi Anesthesia of Biomphalaria spp. (Mollusca, Gastropoda): sodium pentobarbital is the drug of choice
    R Martins-Sousa
    Departamento de Parasitologia, , Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brasil
    Mem Inst Oswaldo Cruz 96:391-2. 2001
    ..effect of some water-soluble anesthesic or narcotic drugs currently used in mice was tested in molluscs of the Biomphalaria genus...
  98. ncbi Transmission studies of intestinal schistosomiasis in Lake Albert, Uganda and experimental compatibility of local Biomphalaria spp
    F Kazibwe
    Ministry of Health, Vector Control Division, P O Box 1661, Kampala, Uganda
    Parasitol Int 59:49-53. 2010
    ..Cercarial shedding patterns of field-caught Biomphalaria spp...
  99. ncbi A Mathematical model of Schistosoma mansoni in Biomphalaria glabrata with control strategies
    Ruijun Zhao
    Department of Mathematics, Purdue University, West Lafayette, IN 47907 2067, USA
    Bull Math Biol 70:1886-905. 2008
    ..Finally, we obtain a critical value for r that indicates the minimum treatment effort needed in order to clear out the disease from the population...
  100. ncbi Microhabitat preferences of Biomphalaria pfeifferi and Lymnaea natalensis in a natural and a man-made habitat in southeastern Tanzania
    J Utzinger
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    Mem Inst Oswaldo Cruz 95:287-94. 2000
    Schistosoma mansoni is an important human parasitic disease which is widespread throughout Africa. As Biomphalaria pfeifferi snails act as intermediate host, knowledge of their population ecology is an essential prerequisite towards ..
  101. ncbi Effect of gamma radiation on the activity of hemocytes and on the course of Schistosoma mansoni infection in resistant Biomphalaria tenagophila snails
    Fernando Schemelzer de Moraes Bezerra
    Faculdade de Farmacia, Odontologia e Enfermagem, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Mem Inst Oswaldo Cruz 98:73-5. 2003
    High doses of gamma radiation (10 Krad) in Biomphalaria tenagophila snails (Taim strain), which have been found to be resistant to Schistosoma mansoni, were not sufficient to impair their resistance to the parasite...

Research Grants32

  1. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2013
    ..and characterize the molecular basis for innate resistance and susceptibility of inbred strains of the snail Biomphalaria glabrata to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic ..
  2. Genetic Analysis of Host Specificity in Schistosoma mansoni
    Tim J Anderson; Fiscal Year: 2013
    ..While Egyptian parasites show strong chemical recognition of the sympatric snail Biomphalaria alexandrina, Brazilian parasites show no specificity and are attracted to even non-vector snail hosts...
  3. UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITY
    CHRISTOPHER JEFFREY BAYNE; Fiscal Year: 2012
    ..Experimental materials include individual Biomphalaria glabrata snails with known susceptible or resistant phenotypes to a standard strain (Oregon PR1) of Schistosoma ..
  4. Innate immune response to microbial PAMPs in the schistosome-transmitting snail,
    John T Sullivan; Fiscal Year: 2012
    ..As in other innate immune systems, the IDS of the vector snail Biomphalaria glabrata is thought to rely on recognition of pathogen-associated molecular patterns (PAMPs) by pattern ..
  5. Snail-Related Studies of Transmission and Control of Schistosomiasis in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2013
    ..This proposal focuses on the interactions between S. mansoni and its most common African snail host, Biomphalaria pfeifferi, as they co-occur in Kenya...
  6. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..innate resistance and susceptibility of inbred strains of the snail Biomphalaria glabrat.;9a to infection by larvae 3N...
  7. PARASITIC CASTRATION IN SNAILS--ROLE OF BIOGENIC AMINES
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..Preliminary findings show that Schistosoma mansoni infection of the snail Biomphalaria glabrata leads to a depression in oviposition and concurrently in the levels of several host biogenic amines in ..
  8. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..The recent characterization of allelic microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides us with an opportunity to study population structure of both parasite and host on a local ..
  9. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2003
    ..The recent characterization of microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides an opportunity to study population structure of both host and parasite on a local spatial ..
  10. DESIGN OF CHEMOTHERAPEUTIC AGENTS
    Paul Talalay; Fiscal Year: 1980
    ..Snails of the species Biomphalaria glabrata refractory to schistosomal infections will be studied in an effort to uncover the mechanisms of this ..
  11. SCHISTOSOME-SNAIL COMPATIBILITY: UNDERLYING MECHANISMS
    Christopher Bayne; Fiscal Year: 1991
    ..which result in transmission of the human blood fluke Schistosoma mansoni in certain individual host snails (Biomphalaria glabrata), and the failure of transmission in others...
  12. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 2002
    ..We propose to use a number of methods in molecular analysis to identify the relevant Biomphalaria glabrata snail genes involved in resistance/susceptibility to Schistosoma mansoni, to determine their ..
  13. ELECTRON MICROSCOPE
    WILLARD GRANATH; Fiscal Year: 1991
    ..Schistosoma mansoni, and one of its' major intermediate hosts. Biomphalaria glabrata. 2...
  14. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 1991
    ..This research will use genetically well- characterized Biomphalaria glabrata stocks and Schistosoma mansoni strains...
  15. Plasma resistance factors in Biomphalaria glabrata
    John Sullivan; Fiscal Year: 2002
    DESCRIPTION: Mechanisms responsible for no susceptibility to infection with Schistosoma mansoni in Biomphalaria glabrata snails are not well understood...
  16. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2010
    ..Understanding the fundamental mechanisms of internal defense in the snail Biomphalaria glabrata may lead to new methods for blocking the transmission of schistosomiasis, a snail-borne disease that ..
  17. IMMUNE PEPTIDES IN AEDES AEGYPTI
    TIMOTHY YOSHINO; Fiscal Year: 2002
    ....
  18. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  19. A gene map for Biomphalaria glabrata, a S. mansoni host
    Matty Knight; Fiscal Year: 2009
    ..Preceding groundwork clearly showed that genetic variations in the snail Biomphalaria glabrata play a major role in the intramolluscan development of the parasitic helminth Schistosoma mansoni...
  20. Anti-pathogen responses in Biomphalaria glabrata
    COENRAAD M ADEMA; Fiscal Year: 2010
    ..Schistosomiasis is transmitted by snail intennediate hosts (such as Biomphalaria glabrata) in which the parasites undergo obligatory development...
  21. BIOLOGY OF TREMATODE-SNAIL ASSOCIATIONS
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..Also, the tools generated will be useful for future studies of schistosome-snail interactions in the field. Our studies will also provide a valuable complement to the upcoming genome sequencing project for B. glabrata. ..
  22. Anti-pathogen responses in Biomphalaria glabrata
    COENRAAD ADEMA; Fiscal Year: 2008
    ..Schistosomiasis is transmitted by snail intermediate hosts such as Biomphalaria glabrata in which the parasites undergo obligatory development...
  23. Evo-epidemiology of Schistosoma mansoni in western Kenya
    ERIC LOKER; Fiscal Year: 2008
    ..mansoni will respond to the vast environmental changes underway in Africa today. ..
  24. Mechanisms of anti-schistosome artemisinin chemotherapy
    David Williams; Fiscal Year: 2006
    ..mansoni translationally controlled tumor protein. The critical conclusions of this study will direct subsequent future experiments into the molecular mechanism of artemisinin's anti-parasitic activity. ..
  25. High Throughput Proteome Analysis of Schistosoma mansoni
    David Williams; Fiscal Year: 2005
    ..Completion of this project will provide information on significant protein complements of S. mansoni and also validate the use of MudPIT in future proteomic studies to define a comprehensive view of the S. mansoni proteomes. ..
  26. Disulfide redox balance in Schistosoma mansoni
    David Williams; Fiscal Year: 2003
    ..Because disulfide redox balance in schistosomes is centered on a single, key enzyme and is fundamentally different from host mechanisms we propose that this pathway is a promising target for novel, rational drug design. ..
  27. Tissue-specific Overexpression of IKKbeta in mice
    PETER MELENDEZ; Fiscal Year: 2003
    ..These studies will determine whether tissue-specific increases in lKKb activity cause whole body insulin resistance and further ask whether lKKb activation in one tissue influences insulin sensitivity in others. ..
  28. URINARY SCHISTOSOMIASIS: INFECTION AND DISEASE
    Charles King; Fiscal Year: 2004
    ..This information, combined with epidemiological modeling of control strategies, will allow accelerated synthesis of the next generation of control programs. ..
  29. Developmental Gene Regulation in Schistosoma mansoni
    David Williams; Fiscal Year: 2006
    ..mansoni genome and studies using DNA micro arrays. Furthermore, we will validate the use of SAGE technology to study differential global gene expression in S. mansoni. ..
  30. HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUM
    Charles King; Fiscal Year: 2005
    ....
  31. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..This will be the first step in the development of novel antischistosome chemotherapies, which are essential for continued public health measures. ..