onchocerca volvulus

Summary

Summary: A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.

Top Publications

  1. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
  2. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
  3. pmc Can ivermectin mass treatments eliminate onchocerciasis in Africa?
    M Winnen
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Bull World Health Organ 80:384-91. 2002
  4. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
  5. ncbi Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet Infect Dis 8:310-22. 2008
  6. ncbi The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania
    Rebekka König
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Parasitology 137:1559-68. 2010
  7. pmc Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
    Clin Microbiol Rev 24:459-68. 2011
  8. ncbi Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan(®)) monotherapy
    E W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA
    Acta Trop 120:S100-8. 2011
  9. ncbi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
  10. pmc Identifying sub-optimal responses to ivermectin in the treatment of River Blindness
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
    Proc Natl Acad Sci U S A 106:16716-21. 2009

Detail Information

Publications243 found, 100 shown here

  1. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
    ....
  2. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
    To eliminate transmission of Onchocerca volvulus, semiannual mass treatment with ivermectin (Mectizan; donated by Merck & Co) has been underway in Guatemala since 2000...
  3. pmc Can ivermectin mass treatments eliminate onchocerciasis in Africa?
    M Winnen
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Bull World Health Organ 80:384-91. 2002
    To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community.
  4. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
    In 1995, the World Bank launched an African Programme for Onchocerciasis Control to eliminate Onchocerca volvulus disease from 19 African countries by means of community-based ivermectin treatment (CBIT)...
  5. ncbi Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet Infect Dis 8:310-22. 2008
    ..in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and inhibition of microfilarial release by female worms remain largely unknown...
  6. ncbi The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania
    Rebekka König
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Parasitology 137:1559-68. 2010
    ..This raises the question of whether these diseases are associated. We therefore investigated people with epilepsy and/or onchocerciasis living in an area in Tanzania endemic for Onchocerca volvulus (O. volvulus).
  7. pmc Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
    Clin Microbiol Rev 24:459-68. 2011
    The discovery of Wolbachia intracellular bacteria within filarial nematodes, including Onchocerca volvulus, the causative agent of onchocerciasis or "river blindness," has delivered a paradigm shift in our understanding of the parasite's ..
  8. ncbi Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan(®)) monotherapy
    E W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA
    Acta Trop 120:S100-8. 2011
    ..Ivermectin has proven exceedingly effective because it is highly efficacious against Onchocerca volvulus microfilariae, the etiological agent of onchocercal skin and ocular disease and the infective stage for the ..
  9. ncbi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
    ....
  10. pmc Identifying sub-optimal responses to ivermectin in the treatment of River Blindness
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
    Proc Natl Acad Sci U S A 106:16716-21. 2009
    ..The variability in the rate at which Onchocerca volvulus microfilariae repopulate host's skin following ivermectin treatment is quantified using an individual-based ..
  11. pmc Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 5:e998. 2011
    ..a reexamination of its microfilaricidal and suppressive effects on reproduction in the adult female Onchocerca volvulus. In an initial study, we demonstrated the continued potent microfilaricidal effect of IVM...
  12. pmc Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply treated population from Cameroon
    Sebastien D S Pion
    UMI 233, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    PLoS Negl Trop Dis 7:e2084. 2013
    ..We assessed, in two Cameroonian foci, whether the microfilaricidal and/or embryostatic effects of ivermectin on Onchocerca volvulus have been altered after several years of drug pressure.
  13. ncbi Onchocerca-Simulium interactions and the population and evolutionary biology of Onchocerca volvulus
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    Adv Parasitol 68:263-313. 2009
    ..A wide range of simuliid species may act as vectors of Onchocerca volvulus, each exerting their own influence over the local epidemiology and the feasibility of controlling/..
  14. ncbi Diagnostic value of nodule palpation in onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Trans R Soc Trop Med Hyg 102:148-54. 2008
    ..Its diagnostic precision is poor because of large intra- and inter-individual variability. The findings underline the need for further development of available diagnostics that allow long-term monitoring when endemicity declines...
  15. pmc Human infection patterns and heterogeneous exposure in river blindness
    Joao A N Filipe
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 102:15265-70. 2005
    Here we analyze patterns of human infection with Onchocerca volvulus (the cause of river blindness) in different continents and ecologies...
  16. ncbi The Ov20 protein of the parasitic nematode Onchocerca volvulus. A structurally novel class of small helix-rich retinol-binding proteins
    M W Kennedy
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 272:29442-8. 1997
    Ov20 is a major antigen of the parasitic nematode Onchocerca volvulus, the causative agent of river blindness in humans, and the protein is secreted into the tissue occupied by the parasite...
  17. ncbi The Onchocerciasis Elimination Program for the Americas (OEPA)
    M Sauerbrey
    Onchocerciasis Elimination Program for the Americas OEPA, 14 Calle 3 51 Zona 10, Edificio Murano Center, Oficina 1401, Guatemala City, Guatemala
    Ann Trop Med Parasitol 102:25-9. 2008
    ..communities that are distributed within the 13 regional foci); (2) eliminate new morbidity caused by Onchocerca volvulus infection by 2007; and (3) eliminate transmission of the parasite wherever feasible...
  18. ncbi Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Boulevard del Maestro Esquina Elías Piña, Col Narciso Mendoza, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 78:147-52. 2008
    ..in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to Onchocerca volvulus. All communities have been receiving ivermectin mass treatment twice per year since 1997...
  19. ncbi Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study
    M P Little
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Lancet 363:1514-21. 2004
    Infection with the parasitic filarial nematode Onchocerca volvulus can lead to severe visual impairment and ultimately blindness...
  20. ncbi The elimination of the vector Simulium neavei from the Itwara onchocerciasis focus in Uganda by ground larviciding
    R Garms
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Acta Trop 111:203-10. 2009
    ..S. neavei was found to be a very efficient vector with 40% of parous flies harbouring developing larvae of Onchocerca volvulus. After 4 years of community-based distribution of ivermectin transmission was still considerable and in ..
  21. ncbi Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments
    Christian Bottomley
    Department of Primary Care and Population Sciences, Royal Free Hospital, Rowland Hill Street, London NW3 2PF
    Parasitology 135:1571-81. 2008
    ..Estimates of the effect of repeated drug treatments on the production of microfilariae by adult Onchocerca volvulus were obtained by developing a model that was fitted to data collected from three hyperendemic communities ..
  22. pmc Lack of active Onchocerca volvulus transmission in the northern Chiapas focus of Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:15-20. 2010
    ..assumed to be representative of the focus as a whole, suggest that there is no ongoing transmission of Onchocerca volvulus in the northern Chiapas focus...
  23. pmc Interruption of Onchocerca volvulus transmission in the Abu Hamed focus, Sudan
    Tarig B Higazi
    Department of Biological Sciences, Ohio University, Zanesville, OH, USA
    Am J Trop Med Hyg 89:51-7. 2013
    ..Similarly, no evidence of Onchocerca volvulus Ov16 antibodies was found in 6,756 school children ≤ 10 years (95% CI UL = 0.03%)...
  24. ncbi Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial
    Jacques Gardon
    Institut Pasteur de la Guyane, Cayenne Cedex, Guyane Francaise, France
    Lancet 360:203-10. 2002
    ..We aimed to compare the effect of higher doses, more frequent doses, or both with the standard regimen on adult Onchocerca volvulus.
  25. ncbi Single nucleotide polymorphisms in β-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: possible indication of resistance selection
    Hugues Nana-Djeunga
    General Biology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
    Mol Biochem Parasitol 185:10-8. 2012
    ..Sub-optimal responses and genetic changes have been reported in Onchocerca volvulus populations under high IVM pressure but more work is needed to determine whether resistance is developing...
  26. pmc Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus
    A Sommer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 69:7718-28. 2001
    b>Onchocerca volvulus is a human pathogenic filarial parasite which, like other parasitic nematodes, is capable of surviving in an immunologically competent host by employing a variety of immune evasion strategies and defense mechanisms ..
  27. ncbi Models for the population biology and control of human onchocerciasis
    M G Basáñez
    Dept of Infectious Disease Epidemiology, Imperial College School of Medicine St Mary s Campus, Norfolk Place, W2 1PG, London, UK
    Trends Parasitol 17:430-8. 2001
    The absence of animal models in which to reproduce successfully the complete life cycle of Onchocerca volvulus has hindered progress towards unravelling the processes involved in the regulation of parasite abundance in the vertebrate ..
  28. ncbi The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Int J Parasitol 34:463-73. 2004
    We investigate the relationship between the microfilarial density in the skin and the burden of adult female Onchocerca volvulus by analysing pre-control nodulectomy data which allow for a direct approach, independent of exposure...
  29. ncbi Polymerase chain reaction monitoring of transmission of Onchocerca volvulus in two endemic states in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 70:38-45. 2004
    To investigate the impact of mass ivermectin treatments in Mexico on Onchocerca volvulus transmission, entomologic surveys were carried out in the two endemic states of Oaxaca and Chiapas...
  30. ncbi P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X3V9
    Mol Biochem Parasitol 158:101-11. 2008
    ..A reduction in response to IVM in Onchocerca volvulus could have significant consequences for the onchocerciasis control programs...
  31. ncbi Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Canada
    Lancet 369:2021-9. 2007
    ..of the long-term use of this drug and the development of resistance in other nematodes, we have assessed Onchocerca volvulus burdens, effectiveness of ivermectin as a microfilaricide, and its effect on adult female worm reproduction.
  32. ncbi A rapid-format antibody card test for diagnosis of onchocerciasis
    G J Weil
    Infectious Diseases Division, Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Infect Dis 182:1796-9. 2000
    ..A rapid-format card test was evaluated that detects IgG4 antibodies to recombinant Onchocerca volvulus antigen Ov16 with serum samples from patients with onchocerciasis and with various types of control serum ..
  33. pmc Population biology of human onchocerciasis
    M G Basáñez
    Wellcome Trust Centre for Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 354:809-26. 1999
    Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector...
  34. ncbi Eliminating onchocerciasis after 14 years of vector control: a proved strategy
    J M Hougard
    Institut de Recherche pour le Developpement, Département Société et Santé, 911 Av Agropolis, BP 5045, 34032 Montpellier Cedex 1, France
    J Infect Dis 184:497-503. 2001
    ....
  35. ncbi The co-administration of ivermectin and albendazole--safety, pharmacokinetics and efficacy against Onchocerca volvulus
    K Awadzi
    Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, P O Box 144, Hohoe, Ghana
    Ann Trop Med Parasitol 97:165-78. 2003
    ..determine whether the co-administration of ivermectin with albendazole is safe and more effective against Onchocerca volvulus than ivermectin alone, and whether a significant pharmacokinetic interaction occurs...
  36. ncbi Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution
    Angel G Guevara
    Laboratory of Clinical Investigation, Community Services Vozandes, Quito, Ecuador
    Am J Trop Med Hyg 68:222-7. 2003
    ..exiguum is a more-competent vector for Onchocerca volvulus than S. quadrivittatum...
  37. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Charles D Mackenzie
    Lancet 370:1123; author reply 1124-5. 2007
  38. ncbi The morphological discrimination of microfilariae of Onchocerca volvulus from Mansonella ozzardi
    R J Post
    Department of Entomology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Parasitology 127:21-7. 2003
    There is no published account which allows the morphological discrimination of microfilariae of Onchocerca volvulus and M. ozzardi from each other...
  39. pmc Rapid suppression of Onchocerca volvulus transmission in two communities of the Southern Chiapas focus, Mexico, achieved by quarterly treatments with Mectizan
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Blvd Del Maestro esq Elias Piña, Cd Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 79:239-44. 2008
    ..The data suggest that Onchocerca volvulus transmission has been suppressed after elimination of microfiladermia in these two communities...
  40. ncbi The Onchocerciasis Control Programme in West Africa (OCP)
    B Boatin
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Ann Trop Med Parasitol 102:13-7. 2008
    ..was initially based successfully interrupted the transmission of the parasite causing human onchocerciasis, Onchocerca volvulus, in many areas...
  41. ncbi Nested PCR to detect and distinguish the sympatric filarial species Onchocerca volvulus, Mansonella ozzardi and Mansonella perstans in the Amazon Region
    Thuy Huong Ta Tang
    Malaria y Protozoos Emergentes, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo Km 2, Majadahonda, Madrid, Spain
    Mem Inst Oswaldo Cruz 105:823-8. 2010
    ..on amplification of first internal transcribed spacer rDNA to distinguish three parasitic filarial species (Onchocerca volvulus, Mansonella ozzardi and Mansonella perstans) that can be found in the Amazon Region...
  42. ncbi Individual host factors associated with Onchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectin
    Sebastien D S Pion
    Unité Mixte de Recherche 145, Institut de Recherche pour le Développement and University of Montpellier 1, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Acta Trop 120:S91-9. 2011
    Reduction in Onchocerca volvulus skin microfilarial densities after treatment with ivermectin shows wide between-host variation...
  43. ncbi Structure of the major cytosolic glutathione S-transferase from the parasitic nematode Onchocerca volvulus
    Markus Perbandt
    Institute of Biochemistry and Foodchemistry, Department of Biochemistry and MolecularBiology, University of Hamburg, Martin Luther King Platz 6, 20146 Hamburg, Germany
    J Biol Chem 280:12630-6. 2005
    Onchocerciasis is a debilitating parasitic disease caused by the filarial worm Onchocerca volvulus. Similar to other helminth parasites, O...
  44. ncbi Impact of parental onchocerciasis and intensity of transmission on development and persistence of Onchocerca volvulus infection in offspring: an 18 year follow-up study
    A K Kirch
    Institute for Tropical Medicine, University of Tubingen, Germany
    Parasitology 127:327-35. 2003
    This study analysed the impact and the extent by which parental Onchocerca volvulus infection, intensity of transmission of O...
  45. ncbi Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2
    Achim Hoerauf
    Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Trends Parasitol 18:25-31. 2002
    ....
  46. ncbi The genomes of Onchocerca volvulus
    T R Unnasch
    Division of Geographic Medicine, University of Alabama at Birmingham, 35294, USA
    Int J Parasitol 30:543-52. 2000
    b>Onchocerca volvulus, the filarial parasite that causes onchocerciasis or river blindness, contains three distinct genomes...
  47. pmc Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event
    Catherine Bourguinat
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    Am J Trop Med Hyg 83:28-32. 2010
    ..An association of high Loa mf load and a genetic predisposition to altered IVM distribution could be involved in IVM SAEs...
  48. pmc Interruption of transmission of Onchocerca volvulus in the Oaxaca focus, Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:21-7. 2010
    ..09%). These meet the criteria for absence of morbidity and parasite transmission in the Oaxaca focus. As a result mass treatments with ivermectin were halted in 2009...
  49. ncbi The effects of long-term community level treatment with ivermectin (Mectizan) on adult Onchocerca volvulus in Latin America
    Eddie W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849 5413, USA
    Am J Trop Med Hyg 71:602-7. 2004
    ..collected over a one-year period (2001) to determine the effects of semi-annual ivermectin treatments on Onchocerca volvulus macrofilarial populations...
  50. ncbi The secretory omega-class glutathione transferase OvGST3 from the human pathogenic parasite Onchocerca volvulus
    Eva Liebau
    Institute of Animal Physiology, University of Munster, Munster, Germany
    FEBS J 275:3438-53. 2008
    Onchocerciasis or river blindness, caused by the filarial nematode Onchocerca volvulus, is the second leading cause of blindness due to infectious diseases. The protective role of the omega-class glutathione transferase 3 from O...
  51. ncbi A comparison of genetic polymorphism in populations of Onchocerca volvulus from untreated- and ivermectin-treated patients
    J K L Eng
    Institute of Parasitology, McGill University, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, Que, Canada H9X 3V9
    Mol Biochem Parasitol 142:193-202. 2005
    An analysis of the polymorphism of 16 genes from Onchocerca volvulus was undertaken, in two populations of worms from either ivermectin-naïve patients or patients who had been repeatedly treated with ivermectin, in Ghana...
  52. ncbi Large-scale entomologic assessment of Onchocerca volvulus transmission by poolscreen PCR in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Cd Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 74:1026-33. 2006
    To study the impact of mass Mectizan treatment on Onchocerca volvulus transmission in Mexico, entomological surveys were carried out in the endemic foci of Oaxaca, Southern Chiapas, and Northern Chiapas...
  53. pmc A four-antigen mixture for rapid assessment of Onchocerca volvulus infection
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Negl Trop Dis 3:e438. 2009
    Onchocerciasis, an infection caused by the filarial nematode Onchocerca volvulus, is a major public health concern...
  54. pmc Successful interruption of transmission of Onchocerca volvulus in the Escuintla-Guatemala focus, Guatemala
    Rodrigo J Gonzalez
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala
    PLoS Negl Trop Dis 3:e404. 2009
    ..We evaluated whether transmission of onchocerciasis has been interrupted in the endemic focus of Escuintla-Guatemala in Guatemala, based on World Health Organization criteria for the certification of elimination of onchocerciasis...
  55. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Ed Cupp
    Lancet 370:1123; author reply 1124-5. 2007
  56. pmc Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
    D Abraham
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 69:262-70. 2001
    Efforts to control Onchocerca volvulus, the etiologic agent of river blindness, have been limited to vector control and drug treatment to eliminate microfilariae, with no means available to prevent infection...
  57. ncbi Control of onchocerciasis
    Boakye A Boatin
    TDR, World Health Organization, CH 1211 Geneva 27, Switzerland
    Adv Parasitol 61:349-94. 2006
    ..A search for a second-line treatment or as an additional drug to ivermectin as well as a search for a macrofilaricide are issues that need to be addressed in the future...
  58. ncbi Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo
    S K Tagboto
    International Institute of Parasitology, St Albans
    Ann Trop Med Parasitol 90:497-505. 1996
    The activity of the veterinary drug moxidectin against Onchocerca volvulus and On. lienalis microfilariae (mf), both in vitro and in experimentally infected CBA/Ca mice, was compared with that of ivermectin...
  59. ncbi Density-dependent host choice by disease vectors: epidemiological implications of the ideal free distribution
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Faculty of Medicine St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Trans R Soc Trop Med Hyg 101:256-69. 2007
    ..Density dependence in the contact rate of infectious diseases transmitted by insects may be an important non-linear process with implications for their epidemiology and control...
  60. ncbi The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...
  61. ncbi Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant
    Guangyu Zhao
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Vaccine 28:7233-40. 2010
    Our previous studies have shown the adjuvanticity of an Onchocerca volvulus recombinant protein, Ov-ASP-1 (ASP-1), when administered in an aqueous formulation with bystander vaccine antigens or commercial vaccines...
  62. ncbi Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect Dis 185:1148-54. 2002
    The cellular immune response to Onchocerca volvulus antigen (OvAg) was studied in 551 persons exposed to O. volvulus transmission in a hyperendemic area of Ghana, West Africa. A whole-blood assay showed that, in response to a soluble O...
  63. ncbi Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response
    P J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 183:1662-8. 2001
    The immune response after early exposure to or infection with Onchocerca volvulus was investigated in an autochthonous focus caused by the migration of infected persons to a previously unaffected area in Ecuador...
  64. pmc Modeling targeted ivermectin treatment for controlling river blindness
    Eric M Poolman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Am J Trop Med Hyg 75:921-7. 2006
    ..Targeted allocation therefore poses significantly lower risk of adverse effects, while potentially delaying the emergence and spread of ivermectin resistance, relative to untargeted allocation...
  65. ncbi Transmission intensity and the patterns of Onchocerca volvulus infection in human communities
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St Mary s Campus, London, United Kingdom
    Am J Trop Med Hyg 67:669-79. 2002
    We focus on possible constraints upon Onchocerca volvulus establishment in humans in relation to exposure rates to infective larvae (L3) as measured by the annual transmission potential (ATP)...
  66. ncbi Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter analysis in transgenic Caenorhabditis elegans
    S Krause
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany
    Mol Biochem Parasitol 117:145-54. 2001
    ..unique extracellular, glycosylated glutathione S-transferases (GSTs) of the human-pathogenic nematode, Onchocerca volvulus (Ov-GST1a and Ov-GST1b), have been isolated and characterised...
  67. pmc Criteria for the differentiation between young and old Onchocerca volvulus filariae
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53105, Bonn, Germany
    Parasitol Res 105:1531-8. 2009
    ..long-lasting inhibition of embryogenesis and microfilaria production or macrofilaricidal activity against Onchocerca volvulus. Therefore, the patients have to be followed-up for several years...
  68. ncbi Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Acta Trop 112:231-5. 2009
    ..We identified PGE(2) in host immune cells adjacent to Onchocerca volvulus in subcutaneous onchocercomas and the affected skin...
  69. ncbi The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta)
    Simone Korten
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359, Hamburg, Germany
    Parasitol Res 105:731-41. 2009
    ..Adult Onchocerca volvulus, Onchocerca gibsoni, Onchocerca ochengi, Onchocerca armillata, Onchocerca fasciata, Onchocerca flexuosa, ..
  70. ncbi Onchocerciasis-related epilepsy? Prospects at a time of uncertainty
    Benoit Marin
    Institut de Neuroépidémiologie et de Neurologie Tropicale EA 3174, Faculte de Medecine, 2 rue de Docteur Marcland, 87025 Limoges Cedex, France
    Trends Parasitol 22:17-20. 2006
    ..are four main mechanisms that might explain a relationship between these two diseases: (i) the presence of Onchocerca volvulus in the central nervous system; (ii) the pathogenicity of various O...
  71. ncbi Analysis of Wuchereria bancrofti infections in a village community in northern Nigeria: increased prevalence in individuals infected with Onchocerca volvulus
    Fred Engelbrecht
    Department of Parasitology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Parasitol Int 52:13-20. 2003
    ..Antibody levels also increased very significantly with age. A further analysis measuring Onchocerca volvulus-specific IgG4 antibodies showed a very significant association between infections with O...
  72. ncbi An internal control for the detection of Onchocerca volvulus DNA by PCR-ELISA and rapid detection of specific PCR products by DNA Detection Test Strips
    S Pischke
    Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trop Med Int Health 7:526-31. 2002
    We developed a polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA) for the detection of Onchocerca volvulus DNA...
  73. ncbi Whither onchocerciasis control in Africa?
    D R Hopkins
    Am J Trop Med Hyg 72:1-2. 2005
  74. ncbi Incidence of blindness during the Onchocerciasis control programme in western Africa, 1971-2002
    Mark P Little
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, St Mary s Campus, London, United Kingdom
    J Infect Dis 189:1932-41. 2004
    Infection with Onchocerca volvulus is associated with the prevalence of severe visual impairment and blindness. However, longitudinal studies of the incidence of blindness caused by onchocerciasis are scarce.
  75. pmc Onchocerca volvulus-specific antibody and cytokine responses in onchocerciasis patients after 16 years of repeated ivermectin therapy
    C S Mai
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Clin Exp Immunol 147:504-12. 2007
    ..for decades, and it remains unknown how repeated ivermectin therapy might affect immunity against Onchocerca volvulus in the long term. O...
  76. ncbi Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin
    B F Ardelli
    Institute of Parasitology, Macdonald Campus, McGill University, 21 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Trans R Soc Trop Med Hyg 101:1223-32. 2007
    ..Genetic variation of an Onchocerca volvulus ABC transporter homologue (OvABC-3) from several populations in Africa was examined to determine whether an ..
  77. ncbi Detection of Onchocerca volvulus in Latin American black flies for pool screening PCR using high-throughput automated DNA isolation for transmission surveillance
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Blvd del Maestro esquina Elías Piña S N, Colonia Narciso Mendoza, 88710, Cd Reynosa, Tamaulipas, Mexico
    Parasitol Res 112:3925-31. 2013
    ..Here, we report a high-throughput automated DNA isolation of Onchocerca volvulus for PCR using a major Latin American black fly vector of onchocerciasis...
  78. ncbi Characterization of a putative nuclear receptor from Onchocerca volvulus
    T R Unnasch
    University of Alabama at Birmingham, Division of Geographic Medicine, 35294 2170, USA
    Mol Biochem Parasitol 104:259-69. 1999
    ..Previous studies have demonstrated that the genome of Onchocerca volvulus encodes at least three members of the nuclear receptor family...
  79. ncbi Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus
    Markus Perbandt
    Institute of Biochemistry, Center for Structural and Cell Biology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Mol Biol 377:501-11. 2008
    Onchocerciasis or river blindness, caused by the filarial worm Onchocerca volvulus, is the world's second leading infectious cause of blindness. In order to chronically infect the host, O...
  80. ncbi Onchocerca volvulus: genetic diversity of parasite isolates from Sudan
    T B Higazi
    Division of Geographic Medicine, BBRB 203, University of Alabama at Birmingham, 35294, USA
    Exp Parasitol 97:24-34. 2001
    ..The significance of these data are discussed in light of knowledge of the biogeography and biology of transmission of O. volvulus in Africa...
  81. pmc Extended result reading window in lateral flow tests detecting exposure to Onchocerca volvulus: a new technology to improve epidemiological surveillance tools
    Allison Golden
    Diagnostics Group, PATH, Seattle, Washington, United States of America
    PLoS ONE 8:e69231. 2013
    Onchocerciasis is a neglected tropical disease caused by infection with the parasite Onchocerca volvulus (Ov). An estimated 180 million people are at risk for Ov infection, and 37 million people are infected, mostly in Africa...
  82. ncbi Molecular characterization and evaluation of Onchocerca volvulus-secreted larval acidic protein 1 (SLAP1) as a putative vaccine candidate on endemic population of lymphatic filariasis
    Natarajan Mahalakshmi
    Centre for Biotechnology, Anna University, Guindy, Chennai, 600025, Tamilnadu, India
    Parasitol Res 112:3203-11. 2013
    ..expression of secreted larval acidic protein 1 (SLAP1) was identified; an ALT orthologue from Onchocerca volvulus was cloned, expressed, and purified as a recombinant protein...
  83. ncbi Antigenic mimicry: Onchocerca volvulus antigen-specific T cells and ocular inflammation
    Nicol M McKechnie
    University of Bristol, Department of Pathology and Microbiology, School of Medical Sciences, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 43:411-8. 2002
    Molecular mimicry has been suggested to play a role in the development of ocular onchocerciasis. The Onchocerca volvulus antigen Ov39 is cross-reactive with the retinal antigen hr44 and induces ocular inflammation in rats after ..
  84. ncbi An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana
    K Awadzi
    Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, P O Box 144, Hohoe, Ghana
    Ann Trop Med Parasitol 98:231-49. 2004
    ..In an open, case-control study, an attempt was made to determine if the persistent, significant, Onchocerca volvulus microfilaridermias seen in some individuals who had received at least nine treatments with ivermectin were ..
  85. pmc Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 4:e660. 2010
    ..could be used without subsequent ivermectin administration to effectively deliver sustained effects on Onchocerca volvulus microfilaridermia and adult viability...
  86. pmc A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2
    Alexandra Sommer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 71:3603-6. 2003
    The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase...
  87. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Gilbert Burnham
    Lancet 370:1125. 2007
  88. ncbi Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum
    Lars Kocherscheidt
    Institute for Tropical Medicine, University Clinics of Tübingen, Wilhelmstr, Tubingen, Germany
    Pediatr Allergy Immunol 21:e756-63. 2010
    ..All study groups were repeatedly exposed to Entamoeba histolytica, Onchocerca volvulus and Plasmodium falciparum infections as indicated by their Immunoglobulin (IgG) responses to parasite-..
  89. pmc Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines
    Wenjun Xiao
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Vaccine 26:5022-9. 2008
    ..We previously showed that activation-associated protein-1 (ASP-1) derived from Onchocerca volvulus has potent adjuvant activity...
  90. ncbi Human infection with Onchocerca volvulus in Asir District (Saudi Arabia)
    Moshira M F Helmy
    Department of Parasitology, Faculty of Medicine, Misr University for Science and Technology, 6th October City, Egypt
    J Egypt Soc Parasitol 33:385-90. 2003
    ..On the other hand, the urine sample of one patient was positive. Six months after the onset of treatment by the clinicians in the Specialized Hospital, skin snips and urine samples were negative...
  91. ncbi Exposure of seasonal migrant workers to Onchocerca volvulus on coffee plantations in Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 81:438-42. 2009
    ..studies undertaken to measure the exposure to onchocerciasis (presence of IgG4 antibodies to a recombinant Onchocerca volvulus antigen, OV-16) among migrant workers...
  92. ncbi Studies on the macrofilarial population of Onchocerca volvulus in hyper-endemic villages of the Central province of Cameroon
    M Boussinesq
    Laboratoire mixte IRD CPC d Epidémiologie et de Santé publique, Centre Pasteur du Cameroun, B P 1274, Yaounde, Cameroon
    Ann Trop Med Parasitol 95:379-88. 2001
    The population structure of Onchocerca volvulus macrofilariae was studied in villages of central Cameroon where onchocerciasis is hyper-endemic...
  93. ncbi Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness)
    E Pearlman
    Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH, USA
    Parasite Immunol 22:625-31. 2000
    Infection with the parasitic nematode Onchocerca volvulus can lead to severe visual impairment and blindness...
  94. ncbi Vector competence for Onchocerca volvulus in the Simulium (Notolepria) exiguum complex: cytoforms or density-dependence?
    Sally Wetten
    Department of Infectious Disease Epidemiology, Imperial College London, Faculty of Medicine St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Acta Trop 103:58-68. 2007
    ..This variable vectorial role has been attributed to sibling forms that differ in their ability to allow Onchocerca volvulus larval development and their preferred bloodmeal hosts...
  95. ncbi Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness)
    J T Kaifi
    Departments of Medicine, Ophthalmology, and Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 41:3856-61. 2000
    ..The purpose of this study was to determine the relative contribution of P- and E-selectin in recruitment of these inflammatory cells from limbal vessels to the corneal stroma...
  96. pmc Comparative analysis of glycosylated and nonglycosylated filarial homologues of the 20-kilodalton retinol binding protein from Onchocerca volvulus (Ov20)
    N Nirmalan
    Department of Biological Sciences, University of Salford, Salford M5 4WT, United Kingdom
    Infect Immun 67:6329-34. 1999
    Ov20 is a structurally novel 20-kDa retinol binding protein secreted by Onchocerca volvulus. Immunological and biological investigation of this protein has been hampered by the inability to maintain O. volvulus in a laboratory setting...
  97. ncbi Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode Onchocerca volvulus
    Birgit Drabner
    Department of Biology, Humboldt University Berlin, Philippstr 13, 10115, Berlin, Germany
    Vaccine 20:3685-94. 2002
    T helper cell-recognized epitopes were determined in chitinase of Onchocerca volvulus, a vaccine candidate protein...
  98. pmc Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells
    N W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Parasitology 137:841-54. 2010
    Up to 5% of untreated female Onchocerca volvulus filariae develop potentially fatal pleomorphic neoplasms, whose incidence is increased following ivermectin treatment...
  99. pmc Molecular and immunological characterization of hr44, a human ocular component immunologically cross-reactive with antigen Ov39 of Onchocerca volvulus
    G Braun
    Department of Pathology, University of Cambridge, United Kingdom
    J Exp Med 182:1121-31. 1995
    ..The unique eye pathology associated with Onchocerca volvulus infection, particularly the development of posterior segment lesions, may be promoted by such autoreactive ..
  100. pmc The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age
    Fidelis Cho-Ngwa
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, United States of America
    PLoS Negl Trop Dis 4:e800. 2010
    Despite considerable efforts, a suitable vaccine against Onchocerca volvulus infection has remained elusive. Herein, we report on the use of molecular tools to identify and characterize O...
  101. pmc Impact of combined large-scale ivermectin distribution and vector control on transmission of Onchocerca volvulus in the Niger basin, Guinea
    P Guillet
    Centre ORSTOM, Montpellier, France
    Bull World Health Organ 73:199-205. 1995
    ..The combined use of ivermectin and vector control has opened up new prospects for carrying out OCP operations with, notably, the possibility of reducing larviciding operations...

Research Grants20

  1. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    Human onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world...
  2. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..Preliminary studies show that Nodding Syndrome is associated with skin infection with the nematode worm Onchocerca volvulus, the cause of onchocerciasis (River Blindness), but additional local environmental factors must participate ..
  3. Development of a novel adjuvant for vaccine sparing
    Hao Shen; Fiscal Year: 2013
    ..We have identified a naturally occurring secreted protein with intrinsic immunostimulatory properties from Onchocerca volvulus (rASP-1) and showed that it is a powerful immunostimulatory adjuvant;it promotes a balanced Th1/Th2 ..
  4. Exploration of Chitinase Inhibitors for Human Health
    Kim D Janda; Fiscal Year: 2013
    ..The infection is caused by the parasitic nematode Onchocerca volvulus, which is transmitted to humans by the blackfly...
  5. Humoral immune profiles at progressive time-points before and after cessation of
    Nidia Rizzo; Fiscal Year: 2013
    ..Levels of IgG4, IgG3 and IgE immunoglobulins directed against different Onchocerca volvulus antigens will be assessed by ELISA, as well as levels of Th type 1 and type 2 immune response related ..
  6. Novel Formulation of Flu Vaccine for the Aged
    Jiu Jiang; Fiscal Year: 2012
    ..Recently, we found that a protein from the helminth parasite Onchocerca volvulus, named O...
  7. BLACK FLY IMMUNITY TO ONCHOCERCA SPP
    EDDIE CUPP; Fiscal Year: 1993
    b>Onchocerca volvulus, is the second leading cause of infectious blindness in the world, infecting an estimated 24,878,200 persons living in 32 countries...
  8. THE ROLE OF BLACK FLY SALIVA IN PARASITE TRANSMISSION
    EDDIE CUPP; Fiscal Year: 1993
    ..the chemical composition of saliva in relation to its possible contribution to successful transmission of Onchocerca volvulus, a major human filarial parasite...
  9. ONCHOCERCIASIS: IMMUNE-MEDIATED EYE DISEASE
    Bulbul Chakravarti; Fiscal Year: 1992
    ..it is caused by infection with filarial parasite Onchocerca volvulus. The major cause of blindness in onchocerciasis is sclerosing keratitis, but its pathogenesis is unclear...
  10. Spatial modeling of onchocerciasis foci in Africa by remote sensing
    Thomas R Unnasch; Fiscal Year: 2013
    Onchocerciasis is a debilitating disease caused by infection with the parasite Onchocerca volvulus. The public health importance of onchocerciasis has been recognized by the international community, which has sponsored several programs ..
  11. IDENTIFICATION--ONCHOCERCA VOLVULUS PROTECTIVE EPITOPES
    THOMAS UNNASCH; Fiscal Year: 1993
    ..Eventually, the epitopes defined by this study may be used to test for the induction of a protective immune response in animal models of Onchocercal infection...
  12. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..immune mechanisms initiated in mice by a strongly immunostimulant protein cloned from the human parasite, Onchocerca volvulus. In our proof-of-principle studies, the LPS-free recombinant O...
  13. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    An estimated 18 millions are infected with Onchocerca volvulus which will result in visual impairment in one million and blindness in more than 400,000...
  14. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  15. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  16. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  17. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2005
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..