onchocerca volvulus

Summary

Summary: A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.

Top Publications

  1. ncbi Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria
    Eric Pearlman
    Center for Global Health and Diseases, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Med Microbiol Immunol 192:57-60. 2003
  2. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
  3. doi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
  4. pmc Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 5:e998. 2011
  5. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
  6. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
  7. pmc Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
    Clin Microbiol Rev 24:459-68. 2011
  8. doi Onchocerca-Simulium interactions and the population and evolutionary biology of Onchocerca volvulus
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    Adv Parasitol 68:263-313. 2009
  9. pmc Identifying sub-optimal responses to ivermectin in the treatment of River Blindness
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
    Proc Natl Acad Sci U S A 106:16716-21. 2009
  10. ncbi Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet Infect Dis 8:310-22. 2008

Detail Information

Publications220 found, 100 shown here

  1. ncbi Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria
    Eric Pearlman
    Center for Global Health and Diseases, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Med Microbiol Immunol 192:57-60. 2003
    ..These observations have led to a new understanding of the pathogenesis of this disease..
  2. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
    ....
  3. doi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
    ....
  4. pmc Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 5:e998. 2011
    ..a reexamination of its microfilaricidal and suppressive effects on reproduction in the adult female Onchocerca volvulus. In an initial study, we demonstrated the continued potent microfilaricidal effect of IVM...
  5. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
    In 1995, the World Bank launched an African Programme for Onchocerciasis Control to eliminate Onchocerca volvulus disease from 19 African countries by means of community-based ivermectin treatment (CBIT)...
  6. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
    To eliminate transmission of Onchocerca volvulus, semiannual mass treatment with ivermectin (Mectizan; donated by Merck & Co) has been underway in Guatemala since 2000...
  7. pmc Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
    Clin Microbiol Rev 24:459-68. 2011
    The discovery of Wolbachia intracellular bacteria within filarial nematodes, including Onchocerca volvulus, the causative agent of onchocerciasis or "river blindness," has delivered a paradigm shift in our understanding of the parasite's ..
  8. doi Onchocerca-Simulium interactions and the population and evolutionary biology of Onchocerca volvulus
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    Adv Parasitol 68:263-313. 2009
    ..A wide range of simuliid species may act as vectors of Onchocerca volvulus, each exerting their own influence over the local epidemiology and the feasibility of controlling/..
  9. pmc Identifying sub-optimal responses to ivermectin in the treatment of River Blindness
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
    Proc Natl Acad Sci U S A 106:16716-21. 2009
    ..The variability in the rate at which Onchocerca volvulus microfilariae repopulate host's skin following ivermectin treatment is quantified using an individual-based ..
  10. ncbi Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet Infect Dis 8:310-22. 2008
    ..in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and inhibition of microfilarial release by female worms remain largely unknown...
  11. ncbi Diagnostic value of nodule palpation in onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Trans R Soc Trop Med Hyg 102:148-54. 2008
    ..Its diagnostic precision is poor because of large intra- and inter-individual variability. The findings underline the need for further development of available diagnostics that allow long-term monitoring when endemicity declines...
  12. pmc Rapid suppression of Onchocerca volvulus transmission in two communities of the Southern Chiapas focus, Mexico, achieved by quarterly treatments with Mectizan
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Blvd Del Maestro esq Elias Piña, Cd Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 79:239-44. 2008
    ..The data suggest that Onchocerca volvulus transmission has been suppressed after elimination of microfiladermia in these two communities...
  13. ncbi Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Boulevard del Maestro Esquina Elías Piña, Col Narciso Mendoza, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 78:147-52. 2008
    ..in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to Onchocerca volvulus. All communities have been receiving ivermectin mass treatment twice per year since 1997...
  14. ncbi Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study
    M P Little
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Lancet 363:1514-21. 2004
    Infection with the parasitic filarial nematode Onchocerca volvulus can lead to severe visual impairment and ultimately blindness...
  15. ncbi Polymerase chain reaction monitoring of transmission of Onchocerca volvulus in two endemic states in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 70:38-45. 2004
    To investigate the impact of mass ivermectin treatments in Mexico on Onchocerca volvulus transmission, entomologic surveys were carried out in the two endemic states of Oaxaca and Chiapas...
  16. ncbi The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Int J Parasitol 34:463-73. 2004
    We investigate the relationship between the microfilarial density in the skin and the burden of adult female Onchocerca volvulus by analysing pre-control nodulectomy data which allow for a direct approach, independent of exposure...
  17. ncbi Models for the population biology and control of human onchocerciasis
    M G Basáñez
    Dept of Infectious Disease Epidemiology, Imperial College School of Medicine St Mary s Campus, Norfolk Place, W2 1PG, London, UK
    Trends Parasitol 17:430-8. 2001
    The absence of animal models in which to reproduce successfully the complete life cycle of Onchocerca volvulus has hindered progress towards unravelling the processes involved in the regulation of parasite abundance in the vertebrate ..
  18. doi Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan(®)) monotherapy
    E W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA
    Acta Trop 120:S100-8. 2011
    ..Ivermectin has proven exceedingly effective because it is highly efficacious against Onchocerca volvulus microfilariae, the etiological agent of onchocercal skin and ocular disease and the infective stage for the ..
  19. pmc Interruption of transmission of Onchocerca volvulus in the Oaxaca focus, Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:21-7. 2010
    ..09%). These meet the criteria for absence of morbidity and parasite transmission in the Oaxaca focus. As a result mass treatments with ivermectin were halted in 2009...
  20. pmc Population biology of human onchocerciasis
    M G Basáñez
    Wellcome Trust Centre for Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 354:809-26. 1999
    Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector...
  21. ncbi The Onchocerciasis Control Programme in West Africa (OCP)
    B Boatin
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Ann Trop Med Parasitol 102:13-7. 2008
    ..was initially based successfully interrupted the transmission of the parasite causing human onchocerciasis, Onchocerca volvulus, in many areas...
  22. ncbi Eliminating onchocerciasis after 14 years of vector control: a proved strategy
    J M Hougard
    Institut de Recherche pour le Developpement, Département Société et Santé, 911 Av Agropolis, BP 5045, 34032 Montpellier Cedex 1, France
    J Infect Dis 184:497-503. 2001
    ....
  23. ncbi The Onchocerciasis Elimination Program for the Americas (OEPA)
    M Sauerbrey
    Onchocerciasis Elimination Program for the Americas OEPA, 14 Calle 3 51 Zona 10, Edificio Murano Center, Oficina 1401, Guatemala City, Guatemala
    Ann Trop Med Parasitol 102:25-9. 2008
    ..communities that are distributed within the 13 regional foci); (2) eliminate new morbidity caused by Onchocerca volvulus infection by 2007; and (3) eliminate transmission of the parasite wherever feasible...
  24. ncbi Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin
    B F Ardelli
    Institute of Parasitology, Macdonald Campus, McGill University, 21 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Trans R Soc Trop Med Hyg 101:1223-32. 2007
    ..Genetic variation of an Onchocerca volvulus ABC transporter homologue (OvABC-3) from several populations in Africa was examined to determine whether an ..
  25. ncbi The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania
    Rebekka König
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Parasitology 137:1559-68. 2010
    ..This raises the question of whether these diseases are associated. We therefore investigated people with epilepsy and/or onchocerciasis living in an area in Tanzania endemic for Onchocerca volvulus (O. volvulus).
  26. ncbi Impact of parental onchocerciasis and intensity of transmission on development and persistence of Onchocerca volvulus infection in offspring: an 18 year follow-up study
    A K Kirch
    Institute for Tropical Medicine, University of Tubingen, Germany
    Parasitology 127:327-35. 2003
    This study analysed the impact and the extent by which parental Onchocerca volvulus infection, intensity of transmission of O...
  27. pmc Lack of active Onchocerca volvulus transmission in the northern Chiapas focus of Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:15-20. 2010
    ..assumed to be representative of the focus as a whole, suggest that there is no ongoing transmission of Onchocerca volvulus in the northern Chiapas focus...
  28. ncbi The genomes of Onchocerca volvulus
    T R Unnasch
    Division of Geographic Medicine, University of Alabama at Birmingham, 35294, USA
    Int J Parasitol 30:543-52. 2000
    b>Onchocerca volvulus, the filarial parasite that causes onchocerciasis or river blindness, contains three distinct genomes...
  29. pmc Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event
    Catherine Bourguinat
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    Am J Trop Med Hyg 83:28-32. 2010
    ..An association of high Loa mf load and a genetic predisposition to altered IVM distribution could be involved in IVM SAEs...
  30. ncbi Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2
    Achim Hoerauf
    Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Trends Parasitol 18:25-31. 2002
    ....
  31. ncbi Whither onchocerciasis control in Africa?
    D R Hopkins
    Am J Trop Med Hyg 72:1-2. 2005
  32. pmc Successful interruption of transmission of Onchocerca volvulus in the Escuintla-Guatemala focus, Guatemala
    Rodrigo J Gonzalez
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala
    PLoS Negl Trop Dis 3:e404. 2009
    ..We evaluated whether transmission of onchocerciasis has been interrupted in the endemic focus of Escuintla-Guatemala in Guatemala, based on World Health Organization criteria for the certification of elimination of onchocerciasis...
  33. ncbi Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Canada
    Lancet 369:2021-9. 2007
    ..of the long-term use of this drug and the development of resistance in other nematodes, we have assessed Onchocerca volvulus burdens, effectiveness of ivermectin as a microfilaricide, and its effect on adult female worm reproduction.
  34. doi The elimination of the vector Simulium neavei from the Itwara onchocerciasis focus in Uganda by ground larviciding
    R Garms
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Acta Trop 111:203-10. 2009
    ..S. neavei was found to be a very efficient vector with 40% of parous flies harbouring developing larvae of Onchocerca volvulus. After 4 years of community-based distribution of ivermectin transmission was still considerable and in ..
  35. ncbi Large-scale entomologic assessment of Onchocerca volvulus transmission by poolscreen PCR in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Cd Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 74:1026-33. 2006
    To study the impact of mass Mectizan treatment on Onchocerca volvulus transmission in Mexico, entomological surveys were carried out in the endemic foci of Oaxaca, Southern Chiapas, and Northern Chiapas...
  36. ncbi Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial
    Jacques Gardon
    Institut Pasteur de la Guyane, Cayenne Cedex, Guyane Francaise, France
    Lancet 360:203-10. 2002
    ..We aimed to compare the effect of higher doses, more frequent doses, or both with the standard regimen on adult Onchocerca volvulus.
  37. doi Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments
    Christian Bottomley
    Department of Primary Care and Population Sciences, Royal Free Hospital, Rowland Hill Street, London NW3 2PF
    Parasitology 135:1571-81. 2008
    ..Estimates of the effect of repeated drug treatments on the production of microfilariae by adult Onchocerca volvulus were obtained by developing a model that was fitted to data collected from three hyperendemic communities ..
  38. pmc A four-antigen mixture for rapid assessment of Onchocerca volvulus infection
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Negl Trop Dis 3:e438. 2009
    Onchocerciasis, an infection caused by the filarial nematode Onchocerca volvulus, is a major public health concern...
  39. ncbi The Ov20 protein of the parasitic nematode Onchocerca volvulus. A structurally novel class of small helix-rich retinol-binding proteins
    M W Kennedy
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 272:29442-8. 1997
    Ov20 is a major antigen of the parasitic nematode Onchocerca volvulus, the causative agent of river blindness in humans, and the protein is secreted into the tissue occupied by the parasite...
  40. ncbi The effects of long-term community level treatment with ivermectin (Mectizan) on adult Onchocerca volvulus in Latin America
    Eddie W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849 5413, USA
    Am J Trop Med Hyg 71:602-7. 2004
    ..collected over a one-year period (2001) to determine the effects of semi-annual ivermectin treatments on Onchocerca volvulus macrofilarial populations...
  41. ncbi The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...
  42. ncbi Transmission intensity and the patterns of Onchocerca volvulus infection in human communities
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St Mary s Campus, London, United Kingdom
    Am J Trop Med Hyg 67:669-79. 2002
    We focus on possible constraints upon Onchocerca volvulus establishment in humans in relation to exposure rates to infective larvae (L3) as measured by the annual transmission potential (ATP)...
  43. ncbi Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution
    Angel G Guevara
    Laboratory of Clinical Investigation, Community Services Vozandes, Quito, Ecuador
    Am J Trop Med Hyg 68:222-7. 2003
    ..exiguum is a more-competent vector for Onchocerca volvulus than S. quadrivittatum...
  44. doi Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant
    Guangyu Zhao
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Vaccine 28:7233-40. 2010
    Our previous studies have shown the adjuvanticity of an Onchocerca volvulus recombinant protein, Ov-ASP-1 (ASP-1), when administered in an aqueous formulation with bystander vaccine antigens or commercial vaccines...
  45. ncbi Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response
    P J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 183:1662-8. 2001
    The immune response after early exposure to or infection with Onchocerca volvulus was investigated in an autochthonous focus caused by the migration of infected persons to a previously unaffected area in Ecuador...
  46. pmc Can ivermectin mass treatments eliminate onchocerciasis in Africa?
    M Winnen
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Bull World Health Organ 80:384-91. 2002
    To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community.
  47. ncbi Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect Dis 185:1148-54. 2002
    The cellular immune response to Onchocerca volvulus antigen (OvAg) was studied in 551 persons exposed to O. volvulus transmission in a hyperendemic area of Ghana, West Africa. A whole-blood assay showed that, in response to a soluble O...
  48. pmc Modeling targeted ivermectin treatment for controlling river blindness
    Eric M Poolman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Am J Trop Med Hyg 75:921-7. 2006
    ..Targeted allocation therefore poses significantly lower risk of adverse effects, while potentially delaying the emergence and spread of ivermectin resistance, relative to untargeted allocation...
  49. ncbi The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta)
    Simone Korten
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359, Hamburg, Germany
    Parasitol Res 105:731-41. 2009
    ..Adult Onchocerca volvulus, Onchocerca gibsoni, Onchocerca ochengi, Onchocerca armillata, Onchocerca fasciata, Onchocerca flexuosa, ..
  50. ncbi Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter analysis in transgenic Caenorhabditis elegans
    S Krause
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany
    Mol Biochem Parasitol 117:145-54. 2001
    ..unique extracellular, glycosylated glutathione S-transferases (GSTs) of the human-pathogenic nematode, Onchocerca volvulus (Ov-GST1a and Ov-GST1b), have been isolated and characterised...
  51. pmc Criteria for the differentiation between young and old Onchocerca volvulus filariae
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53105, Bonn, Germany
    Parasitol Res 105:1531-8. 2009
    ..long-lasting inhibition of embryogenesis and microfilaria production or macrofilaricidal activity against Onchocerca volvulus. Therefore, the patients have to be followed-up for several years...
  52. doi Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Acta Trop 112:231-5. 2009
    ..We identified PGE(2) in host immune cells adjacent to Onchocerca volvulus in subcutaneous onchocercomas and the affected skin...
  53. ncbi Antigenic mimicry: Onchocerca volvulus antigen-specific T cells and ocular inflammation
    Nicol M McKechnie
    University of Bristol, Department of Pathology and Microbiology, School of Medical Sciences, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 43:411-8. 2002
    Molecular mimicry has been suggested to play a role in the development of ocular onchocerciasis. The Onchocerca volvulus antigen Ov39 is cross-reactive with the retinal antigen hr44 and induces ocular inflammation in rats after ..
  54. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Gilbert Burnham
    Lancet 370:1125. 2007
  55. ncbi An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana
    K Awadzi
    Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, P O Box 144, Hohoe, Ghana
    Ann Trop Med Parasitol 98:231-49. 2004
    ..In an open, case-control study, an attempt was made to determine if the persistent, significant, Onchocerca volvulus microfilaridermias seen in some individuals who had received at least nine treatments with ivermectin were ..
  56. pmc A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2
    Alexandra Sommer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 71:3603-6. 2003
    The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase...
  57. ncbi Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum
    Lars Kocherscheidt
    Institute for Tropical Medicine, University Clinics of Tübingen, Wilhelmstr, Tubingen, Germany
    Pediatr Allergy Immunol 21:e756-63. 2010
    ..All study groups were repeatedly exposed to Entamoeba histolytica, Onchocerca volvulus and Plasmodium falciparum infections as indicated by their Immunoglobulin (IgG) responses to parasite-..
  58. pmc Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 4:e660. 2010
    ..could be used without subsequent ivermectin administration to effectively deliver sustained effects on Onchocerca volvulus microfilaridermia and adult viability...
  59. pmc Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines
    Wenjun Xiao
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Vaccine 26:5022-9. 2008
    ..We previously showed that activation-associated protein-1 (ASP-1) derived from Onchocerca volvulus has potent adjuvant activity...
  60. ncbi Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness)
    E Pearlman
    Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH, USA
    Parasite Immunol 22:625-31. 2000
    Infection with the parasitic nematode Onchocerca volvulus can lead to severe visual impairment and blindness...
  61. ncbi Vector competence for Onchocerca volvulus in the Simulium (Notolepria) exiguum complex: cytoforms or density-dependence?
    Sally Wetten
    Department of Infectious Disease Epidemiology, Imperial College London, Faculty of Medicine St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Acta Trop 103:58-68. 2007
    ..This variable vectorial role has been attributed to sibling forms that differ in their ability to allow Onchocerca volvulus larval development and their preferred bloodmeal hosts...
  62. ncbi Studies on the macrofilarial population of Onchocerca volvulus in hyper-endemic villages of the Central province of Cameroon
    M Boussinesq
    Laboratoire mixte IRD CPC d Epidémiologie et de Santé publique, Centre Pasteur du Cameroun, B P 1274, Yaounde, Cameroon
    Ann Trop Med Parasitol 95:379-88. 2001
    The population structure of Onchocerca volvulus macrofilariae was studied in villages of central Cameroon where onchocerciasis is hyper-endemic...
  63. ncbi Exposure of seasonal migrant workers to Onchocerca volvulus on coffee plantations in Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 81:438-42. 2009
    ..studies undertaken to measure the exposure to onchocerciasis (presence of IgG4 antibodies to a recombinant Onchocerca volvulus antigen, OV-16) among migrant workers...
  64. ncbi Human infection with Onchocerca volvulus in Asir District (Saudi Arabia)
    Moshira M F Helmy
    Department of Parasitology, Faculty of Medicine, Misr University for Science and Technology, 6th October City, Egypt
    J Egypt Soc Parasitol 33:385-90. 2003
    ..On the other hand, the urine sample of one patient was positive. Six months after the onset of treatment by the clinicians in the Specialized Hospital, skin snips and urine samples were negative...
  65. ncbi Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness)
    J T Kaifi
    Departments of Medicine, Ophthalmology, and Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 41:3856-61. 2000
    ..The purpose of this study was to determine the relative contribution of P- and E-selectin in recruitment of these inflammatory cells from limbal vessels to the corneal stroma...
  66. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Charles D Mackenzie
    Lancet 370:1123; author reply 1124-5. 2007
  67. pmc Comparative analysis of glycosylated and nonglycosylated filarial homologues of the 20-kilodalton retinol binding protein from Onchocerca volvulus (Ov20)
    N Nirmalan
    Department of Biological Sciences, University of Salford, Salford M5 4WT, United Kingdom
    Infect Immun 67:6329-34. 1999
    Ov20 is a structurally novel 20-kDa retinol binding protein secreted by Onchocerca volvulus. Immunological and biological investigation of this protein has been hampered by the inability to maintain O. volvulus in a laboratory setting...
  68. ncbi Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode Onchocerca volvulus
    Birgit Drabner
    Department of Biology, Humboldt University Berlin, Philippstr 13, 10115, Berlin, Germany
    Vaccine 20:3685-94. 2002
    T helper cell-recognized epitopes were determined in chitinase of Onchocerca volvulus, a vaccine candidate protein...
  69. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Jan H F Remme
    Lancet 370:1123-4; author reply 1124-5. 2007
  70. doi Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 198:427-33. 2008
    Human infections with the tissue nematode Onchocerca volvulus show strong interindividual variation in intensity, which cannot be explained by differences in exposure alone...
  71. ncbi The peroxidoxin 2 protein of the human parasite Onchocerca volvulus: recombinant expression, immunolocalization, and demonstration of homologous molecules in other species
    P F Zipfel
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Parasitol Res 84:623-31. 1998
    The peroxidoxin protein of the filarial parasite Onchocerca volvulus (OvPXN-2) belongs to a group of highly conserved antioxidant molecules...
  72. ncbi The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)
    Achim Hoerauf
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Microbes Infect 4:37-42. 2002
    b>Onchocerca volvulus infection usually results in a predominantly immunopermissive reaction called generalized onchocerciasis and characterized by high microfilarial burden and immunological tolerance to the worms...
  73. pmc Impact of combined large-scale ivermectin distribution and vector control on transmission of Onchocerca volvulus in the Niger basin, Guinea
    P Guillet
    Centre ORSTOM, Montpellier, France
    Bull World Health Organ 73:199-205. 1995
    ..The combined use of ivermectin and vector control has opened up new prospects for carrying out OCP operations with, notably, the possibility of reducing larviciding operations...
  74. ncbi Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo
    S K Tagboto
    International Institute of Parasitology, St Albans
    Ann Trop Med Parasitol 90:497-505. 1996
    The activity of the veterinary drug moxidectin against Onchocerca volvulus and On. lienalis microfilariae (mf), both in vitro and in experimentally infected CBA/Ca mice, was compared with that of ivermectin...
  75. ncbi Wolbachia endosymbiont levels in severe and mild strains of Onchocerca volvulus
    Tarig B Higazi
    Division of Geographic Medicine, University of Alabama at Birmingham, BBRB 203, 1530 3rd Avenue South, Birmingham, AL 35294 2170, USA
    Mol Biochem Parasitol 141:109-12. 2005
    Epidemiological, clinical and genetic data have all suggested that the filarial parasite Onchocerca volvulus, the causative agent of onchocerciasis (or river blindness) exists as two strains in West Africa...
  76. pmc Molecular and immunological characterization of hr44, a human ocular component immunologically cross-reactive with antigen Ov39 of Onchocerca volvulus
    G Braun
    Department of Pathology, University of Cambridge, United Kingdom
    J Exp Med 182:1121-31. 1995
    ..The unique eye pathology associated with Onchocerca volvulus infection, particularly the development of posterior segment lesions, may be promoted by such autoreactive ..
  77. pmc The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age
    Fidelis Cho-Ngwa
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, United States of America
    PLoS Negl Trop Dis 4:e800. 2010
    Despite considerable efforts, a suitable vaccine against Onchocerca volvulus infection has remained elusive. Herein, we report on the use of molecular tools to identify and characterize O...
  78. ncbi Efficacy of ivermectin against Onchocerca volvulus in Ghana
    Ed Cupp
    Lancet 370:1123; author reply 1124-5. 2007
  79. pmc Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells
    N W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Parasitology 137:841-54. 2010
    Up to 5% of untreated female Onchocerca volvulus filariae develop potentially fatal pleomorphic neoplasms, whose incidence is increased following ivermectin treatment...
  80. ncbi Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms
    Achim Hoerauf
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Microbes Infect 5:261-73. 2003
    ..Extension of the existing registration will not require much time or high cost. Treatment of individual patients can be considered immediately...
  81. doi Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia
    Simone Korten
    Institute of Medical Microbiology, Immunology and Parasitology IMMIP, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Microbes Infect 12:555-64. 2010
    ..in subcutaneous nodules from highly infected, hyporeactive onchocerciasis patients, harbouring adult Onchocerca volvulus. Since many cell types produce TGF-beta, we elucidated the cellular source, distribution and dependency on ..
  82. doi Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Parasitol Res 103:1303-9. 2008
    ..The loss of Wolbachia results in sterilization of Onchocerca volvulus and macrofilaricidal effects...
  83. pmc Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae
    David Abraham
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 72:810-7. 2004
    Mice immunized with irradiated Onchocerca volvulus third-stage larvae developed protective immunity...
  84. pmc Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:2442-5. 2006
    Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness...
  85. ncbi Short report: impact of ivermectin community-level treatments on elimination of adult Onchocerca volvulus when individuals receive multiple treatments per year
    Eddie W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama 36849 5413, USA
    Am J Trop Med Hyg 73:1159-61. 2005
    ..The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment...
  86. ncbi Co-infection with Onchocerca volvulus and Loa loa microfilariae in central Cameroon: are these two species interacting?
    S D S Pion
    Laboratoire mixte IRD, Institut de Recherche pour le Developpement, CPC, Centre Pasteur du Cameroun d Epidémiologie et de Santé publique, Centre Pasteur du Cameroun, BP 1274, Yaounde, Cameroun
    Parasitology 132:843-54. 2006
    ..This hampers the implementation of mass ivermectin treatment against onchocerciasis in areas where Onchocerca volvulus and L. loa are co-endemic...
  87. ncbi Antibody detection tests for Onchocerca volvulus: comparison of the sensitivity of a cocktail of recombinant antigens used in the indirect enzyme-linked immunosorbent assay with a rapid-format antibody card test
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Boulevard del Maestro Esquina Elías Piña, Reynosa, Tamaulipas, Mexico
    Trans R Soc Trop Med Hyg 97:539-41. 2003
    ..The sensitivity of the ELISA and ICT was 97% and 86%, respectively...
  88. ncbi Ivermectin selection on beta-tubulin: evidence in Onchocerca volvulus and Haemonchus contortus
    J K L Eng
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    Mol Biochem Parasitol 150:229-35. 2006
    ..the only drug approved for mass administration to control onchocerciasis caused by the nematode parasite, Onchocerca volvulus. In parts of West Africa up to 18 rounds of ivermectin treatment have been administered to communities and ..
  89. ncbi Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunity
    A J MacDonald
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Parasite Immunol 26:53-62. 2004
    Vaccination of mice with a recombinant protein, Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted gene family stimulated very high titres of both IgG1 and IgG2a without adjuvant...
  90. ncbi Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis
    H P Duerr
    Department of Medical Biometry, Institute of Tropical Medicine, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Trans R Soc Trop Med Hyg 97:242-50. 2003
    ..We address the unresolved question of acquisition, establishment and accumulation of Onchocerca volvulus by using a modelling approach that relates computer simulations to cross-sectional data concerning parasite ..
  91. ncbi The safety, tolerability and pharmacokinetics of levamisole alone, levamisole plus ivermectin, and levamisole plus albendazole, and their efficacy against Onchocerca volvulus
    K Awadzi
    Onchocerciasis Chemotherapy Research Centre OCRC, Hohoe Hospital, P O Box 144, Hohoe, Ghana
    Ann Trop Med Parasitol 98:595-614. 2004
    ..the safety of the same treatment regimens and their efficacy against the adult worms and microfilariae of Onchocerca volvulus were investigated in 66 infected subjects of both sexes...
  92. ncbi Successful vaccination against Onchocerca ochengi infestation in cattle using live Onchocerca volvulus infective larvae
    M D Achukwi
    Institute of Agricultural Research for Development, Wakwa Regional Centre, PO Box 65, Ngaoundere, Cameroon
    Parasite Immunol 29:113-6. 2007
    ..l. in sub-Saharan Africa could lead to the protection of humans against onchocerciasis caused by Onchocerca volvulus (zooprophylaxis). To gain support for this hypothesis, we investigated whether exposure to O...
  93. pmc Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic, Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:295-311. 2008
    ..Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections...
  94. ncbi Mast cell distribution in nodules of Onchocerca volvulus from untreated patients with generalized onchocerciasis
    G Wildenburg
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Parasitology 116:257-68. 1998
    ..appeared singly or in diffuse accumulations perivascularly and in inflammatory infiltrates between adult Onchocerca volvulus and in the capsular area. No mast cells were detected in cystic parts...
  95. ncbi Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment
    A Hoerauf
    Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany
    Lancet 357:1415-6. 2001
    ....
  96. ncbi Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria
    N W Brattig
    Department of Clinical Chemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Microbes Infect 3:439-46. 2001
    ..treatment) are direct and indirect sources of signals accounting for neutrophil accumulation around adult Onchocerca volvulus filariae...
  97. pmc Onchocerca volvulus: comparison of field collection methods for the preservation of parasite and vector samples for PCR analysis
    L Toe
    Onchocerciasis Control Programme, Bouake, Cote d Ivoire
    Bull World Health Organ 75:443-7. 1997
    In recent years, methods for the identification of the filarial worm Onchocerca volvulus and its vector, blackflies of the Simulium damnosum complex (S. damnosum sensu lato (s.l...
  98. ncbi Regional genetic variation in the major sperm protein genes of Onchocerca volvulus and Mansonella ozzardi (Nematoda: Filarioidea)
    R M Hojas
    Department of Entomology, The Natural History Museum, London, UK
    Int J Parasitol 30:1459-65. 2000
    b>Onchocerca volvulus and Mansonella ozzardi are two human filarial parasites present in South and Central America...
  99. doi P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X3V9
    Mol Biochem Parasitol 158:101-11. 2008
    ..A reduction in response to IVM in Onchocerca volvulus could have significant consequences for the onchocerciasis control programs...
  100. ncbi Cloning, characterization and DNA immunization of an Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH)
    Klaus D Erttmann
    Bernhard Nocht Institute for Tropical Medecine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Biochim Biophys Acta 1741:85-94. 2005
    In the search for Onchocerca volvulus antigens possibly involved in protection against human onchocerciasis, partial amino acid sequence analysis of one of the O...
  101. ncbi Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus
    Y Wu
    Liverpool School of Tropical Medicine, UK
    Mol Biochem Parasitol 75:207-19. 1996
    ..Primers based on the A. viteae sequence were used to amplify a related sequence from a cDNA library of Onchocerca volvulus infective larvae. The O...

Research Grants75

  1. BLACK FLY IMMUNITY TO ONCHOCERCA SPP
    EDDIE CUPP; Fiscal Year: 1991
    b>Onchocerca volvulus, is the second leading cause of infectious blindness in the world, infecting an estimated 24,878,200 persons living in 32 countries...
  2. BLACK FLY IMMUNITY TO ONCHOCERCA SPP
    EDDIE CUPP; Fiscal Year: 1993
    b>Onchocerca volvulus, is the second leading cause of infectious blindness in the world, infecting an estimated 24,878,200 persons living in 32 countries...
  3. THE ROLE OF BLACK FLY SALIVA IN PARASITE TRANSMISSION
    EDDIE CUPP; Fiscal Year: 1991
    ..the chemical composition of saliva in relation to its possible contribution to successful transmission of Onchocerca volvulus, a major human filarial parasite...
  4. THE ROLE OF BLACK FLY SALIVA IN PARASITE TRANSMISSION
    EDDIE CUPP; Fiscal Year: 1993
    ..the chemical composition of saliva in relation to its possible contribution to successful transmission of Onchocerca volvulus, a major human filarial parasite...
  5. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2005
    ..are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the Onchocerca volvulus, which causes river blindness...
  6. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2006
    ..are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the Onchocerca volvulus, which causes river blindness...
  7. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2007
    ..are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the Onchocerca volvulus, which causes river blindness...
  8. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2007
    ..are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the Onchocerca volvulus, which causes river blindness...
  9. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2004
    ..are essential symbionts of the major pathogenic filarial nematode parasites of humans, including the Onchocerca volvulus, which causes river blindness...
  10. IMMUNE RESPONSES TO ONCHOCERCA VOLVULUS IN ECUADOR
    Michael Kron; Fiscal Year: 1991
    Human infection with the filarial parasite Onchocerca volvulus, onchocerciasis, or river blindness, is a chronic disease which affects an estimated 20 million humans throughout Africa, Mexico, Central and South America...
  11. ONCHOCERCIASIS: IMMUNE-MEDIATED EYE DISEASE
    BRUCE GREENE; Fiscal Year: 1990
    ..it is caused by infection with filarial parasite Onchocerca volvulus. The major cause of blindness in onchocerciasis is sclerosing keratitis, but its pathogenesis is unclear...
  12. The molecular basis of bacteria-host interaction Drosophila melanogaster
    LAURA SERBUS; Fiscal Year: 2007
    ..Wolbachia have recently been shown cause blindness in humans upon release from their nematode host Onchocerca volvulus. Wolbachia have also been shown to infect the well-established model organism Drosophila melanogaster...
  13. MOLECULAR PARASITOLOGY AND PARASITIC DISEASE
    BRUCE GREENE; Fiscal Year: 1991
    The long-term objective of this Program is to define antigens of Onchocerca volvulus that are related to development of ocular and skin disease and to improve our understanding of molecular pathogenesis...
  14. EOSINOPHILS IN ONCHOCERCA VOLVULUS-MEDIATED KERATITIS
    Eric Pearlman; Fiscal Year: 1999
    ..These studies are intended to enhance the understanding of the immunopathology of onchocercal keratitis and other eosinophil mediated forms of keratitis. ..
  15. EOSINOPHILS IN ONCHOCERCA VOLVULUS-MEDIATED KERATITIS
    Eric Pearlman; Fiscal Year: 2000
    ..These studies are intended to enhance the understanding of the immunopathology of onchocercal keratitis and other eosinophil mediated forms of keratitis. ..
  16. IDENTIFICATION--ONCHOCERCA VOLVULUS PROTECTIVE EPITOPES
    THOMAS UNNASCH; Fiscal Year: 1990
    ..Eventually, the epitopes defined by this study may be used to test for the induction of a protective immune response in animal models of Onchocercal infection...
  17. VECTOR-PARASITE COMPLEXES IN ONCHOCERCIASIS
    THOMAS UNNASCH; Fiscal Year: 1993
    The filarial parasite Onchocerca volvulus is endemic throughout sub-Saharan Africa. Several lines of evidence suggest that different strains of the parasite exist in the forest and savannah bioclimes...
  18. Spacial modeling of onchocerciasis foci in Africa by remote sensing
    THOMAS UNNASCH; Fiscal Year: 2009
    Onchocerciasis is a debilitating disease caused by infection with the parasite Onchocerca volvulus. The public health importance of onchocerciasis has been recognized by the international community, which has sponsored several programs ..
  19. Spacial modeling of onchocerciasis foci in Africa by remote sensing
    Thomas R Unnasch; Fiscal Year: 2010
    Onchocerciasis is a debilitating disease caused by infection with the parasite Onchocerca volvulus. The public health importance of onchocerciasis has been recognized by the international community, which has sponsored several programs ..
  20. IN VITRO CULTIVATION OF ONCHOCERCA VOLVULUS
    EVERETT SCHILLER; Fiscal Year: 1980
    Techniques developed in this laboratory for the cryopreservation and in vitro cultivation of larval Onchocerca volvulus are being employed in a series of morphogenetic, physiologic, chemotherapeutic and immunologic investigations of this ..
  21. NEUTROPHILS AND EOSINOPHILS IN ONCHOCERCA KERATITIS
    Eric Pearlman; Fiscal Year: 2001
    ..for immune-complex mediated recruitment of neutrophils and eosinophils to the cornea in a murine model for Onchocerca volvulus keratitis (river blindness). The proposed studies will assess the role of C5a, and...
  22. NEUTROPHILS AND EOSINOPHILS IN ONCHOCERCA KERATITIS
    Eric Pearlman; Fiscal Year: 2003
    ..for immune-complex mediated recruitment of neutrophils and eosinophils to the cornea in a murine model for Onchocerca volvulus keratitis (river blindness). The proposed studies will assess the role of C5a, and...
  23. NEUTROPHILS AND EOSINOPHILS IN ONCHOCERCA KERATITIS
    Eric Pearlman; Fiscal Year: 2002
    ..for immune-complex mediated recruitment of neutrophils and eosinophils to the cornea in a murine model for Onchocerca volvulus keratitis (river blindness). The proposed studies will assess the role of C5a, and...
  24. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2005
    ..immune mechanisms initiated in mice by a strongly immunostimulant protein cloned from the human parasite, Onchocerca volvulus. In our proof-of-principle studies, the LPS-free recombinant O...
  25. Novel Protein Adjuvant for Flu Vaccines
    Jiu Jiang; Fiscal Year: 2010
    ..We have identified a protein from the helminth parasite Onchocerca volvulus, named O...
  26. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  27. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world...
  28. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..immune mechanisms initiated in mice by a strongly immunostimulant protein cloned from the human parasite, Onchocerca volvulus. In our proof-of-principle studies, the LPS-free recombinant O...
  29. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Human onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world...
  30. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    An estimated 18 millions are infected with Onchocerca volvulus which will result in visual impairment in one million and blindness in more than 400,000...
  31. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2004
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  32. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2001
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  33. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2002
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  34. Malaria in Brazil: RBC variants & parasite invasion
    Sara Lustigman; Fiscal Year: 2008
    ..Our studies could also impact development of global vaccines against P. falciparum malaria that target multiple determinants of merozoite invasion. ..
  35. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2003
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  36. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2000
    An estimated 18 millions are infected with Onchocerca volvulus which will result in visual impairment in one million and blindness in more than 400,000...
  37. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 1999
    An estimated 18 millions are infected with Onchocerca volvulus which will result in visual impairment in one million and blindness in more than 400,000...
  38. Host Defense in Oral Candidiasis
    Amy G Hise; Fiscal Year: 2010
    ....
  39. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  40. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2007
    ....
  41. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2001
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  42. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  43. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  44. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2001
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  45. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2009
    ..abstract_text> ..
  46. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2009
    ....
  47. Research for the Elimination of Lymphatic Filariasis
    Gary Weil; Fiscal Year: 2008
    ..Lessons learned in Egypt will benefit PELFs around the world. ..
  48. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2004
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  49. Research for the Elimination of Lymphatic Filariasis
    Gary Weil; Fiscal Year: 2005
    ..Lessons learned in Egypt will benefit PELFs around the world. ..
  50. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2003
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  51. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2002
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  52. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2000
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  53. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2005
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  54. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2008
    ....
  55. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2004
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  56. Research for the Elimination of Lymphatic Filariasis
    Gary Weil; Fiscal Year: 2007
    ..Lessons learned in Egypt will benefit PELFs around the world. ..