holothuria

Summary

Summary: A genus of large SEA CUCUMBERS in the family Holothuriidae possessing thick body walls, a warty body surface, and microscopic ossicles.

Top Publications

  1. ncbi Echinoderms: their culture and bioactive compounds
    M S Kelly
    Scottish Association for Marine Science, Oban, Argyll, Scotland, PA37 IQA, UK
    Prog Mol Subcell Biol 39:139-65. 2005
  2. doi Phylogeography of the Atlanto-Mediterranean sea cucumber Holothuria (Holothuria) mammata: the combined effects of historical processes and current oceanographical pattern
    G H Borrero-Pérez
    Departamento de Ecología e Hidrología, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Mol Ecol 20:1964-75. 2011
  3. ncbi Transdifferentiation in holothurian gut regeneration
    Vladimir S Mashanov
    Institute of Marine Biology FEB RAS, Palchevsky 17, 690041 Vladivostok, Russia
    Biol Bull 209:184-93. 2005
  4. doi T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): possible involvement in differential recognition of bacteria
    Nagaraj M Gowda
    Gene Lab, National Institute of Oceanography, Goa 403 004, India Division of Biochemical Sciences, National Chemical Laboratory, Pune 411 008, India
    J Invertebr Pathol 99:141-5. 2008
  5. ncbi Tensilin-like stiffening protein from Holothuria leucospilota does not induce the stiffest state of catch connective tissue
    Masaki Tamori
    W3 42, Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, O okayama 2 12 1, Tokyo 152 8551, Japan
    J Exp Biol 209:1594-602. 2006
  6. doi Two new cytotoxic triterpene glycosides from the sea cucumber Holothuria scabra
    Hua Han
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Planta Med 75:1608-12. 2009
  7. ncbi Nobilisides A - C, three new triterpene glycosides from the sea cucumber Holothuria nobilis
    Jun Wu
    Research Center for Marine Drugs, College of Pharmacy, Second Military Medical University, Shanghai, PR China
    Planta Med 72:932-5. 2006
  8. doi A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota
    Hua Han
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai 200433, P R China
    Chem Biodivers 7:1764-9. 2010
  9. ncbi A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens
    Peng Sun
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China
    Chem Biodivers 4:450-7. 2007
  10. doi Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra)
    Nagaraj M Gowda
    Gene Laboratory, National Institute of Oceanography, Dona Paula, Goa 403 004, India
    Fish Shellfish Immunol 24:450-8. 2008

Scientific Experts

Detail Information

Publications97

  1. ncbi Echinoderms: their culture and bioactive compounds
    M S Kelly
    Scottish Association for Marine Science, Oban, Argyll, Scotland, PA37 IQA, UK
    Prog Mol Subcell Biol 39:139-65. 2005
    ..Methods for mass cultivation of the tropical Holothuria scabra are now well established and practised in India, Australia, Indonesia, the Maldives and the Solomon ..
  2. doi Phylogeography of the Atlanto-Mediterranean sea cucumber Holothuria (Holothuria) mammata: the combined effects of historical processes and current oceanographical pattern
    G H Borrero-Pérez
    Departamento de Ecología e Hidrología, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Mol Ecol 20:1964-75. 2011
    We assessed the genetic structure of populations of the widely distributed sea cucumber Holothuria (Holothuria) mammata Grube, 1840, and investigated the effects of marine barriers to gene flow and historical processes...
  3. ncbi Transdifferentiation in holothurian gut regeneration
    Vladimir S Mashanov
    Institute of Marine Biology FEB RAS, Palchevsky 17, 690041 Vladivostok, Russia
    Biol Bull 209:184-93. 2005
    ..from the mesodermally derived mesothelium and the endodermally derived epithelium of the cloacal lining, respectively. Our data suggest that differentiated cells of echinoderms are capable of transdifferentiation into other cell types...
  4. doi T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): possible involvement in differential recognition of bacteria
    Nagaraj M Gowda
    Gene Lab, National Institute of Oceanography, Goa 403 004, India Division of Biochemical Sciences, National Chemical Laboratory, Pune 411 008, India
    J Invertebr Pathol 99:141-5. 2008
    ..this article, we report a study of a lectin (HSL) involved in immune response in the echinoderm, sea cucumber (Holothuria scabra)...
  5. ncbi Tensilin-like stiffening protein from Holothuria leucospilota does not induce the stiffest state of catch connective tissue
    Masaki Tamori
    W3 42, Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, O okayama 2 12 1, Tokyo 152 8551, Japan
    J Exp Biol 209:1594-602. 2006
    ..We purified a similar protein, H-tensilin, from Holothuria leucospilota, which belongs to a different family to C. frondosa...
  6. doi Two new cytotoxic triterpene glycosides from the sea cucumber Holothuria scabra
    Hua Han
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Planta Med 75:1608-12. 2009
    ..scabraside A (1) and B (2), and a structurally known compound (3), were isolated from the sea cucumber Holothuria scabra (Holothuriidae) collected from the South China Sea...
  7. ncbi Nobilisides A - C, three new triterpene glycosides from the sea cucumber Holothuria nobilis
    Jun Wu
    Research Center for Marine Drugs, College of Pharmacy, Second Military Medical University, Shanghai, PR China
    Planta Med 72:932-5. 2006
    Three new triterpene glycosides, named nobilisides A ( 1), B ( 2) and C ( 3), were isolated from the sea cucumber Holothuria nobilis Selenka. Their structures were deduced by extensive spectral analysis and chemical evidence...
  8. doi A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota
    Hua Han
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai 200433, P R China
    Chem Biodivers 7:1764-9. 2010
    ..related structurally known compounds holothurin B(2) (2) and holothurin B (3), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea...
  9. ncbi A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens
    Peng Sun
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China
    Chem Biodivers 4:450-7. 2007
    A new lanostane-type triterpene glycoside, impatienside A (1), was isolated from the sea cucumber Holothuria impatiens, together with a structurally related, known compound, bivittoside D (2)...
  10. doi Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra)
    Nagaraj M Gowda
    Gene Laboratory, National Institute of Oceanography, Dona Paula, Goa 403 004, India
    Fish Shellfish Immunol 24:450-8. 2008
    A novel lectin was purified from the coelomic fluid of the sea cucumber Holothuria scabra (HSL), subjected to bacterial challenge. HSL is a monomeric glycoprotein of molecular mass 182 kDa...
  11. pmc Common cellular events occur during wound healing and organ regeneration in the sea cucumber Holothuria glaberrima
    José E San Miguel-Ruiz
    Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico
    BMC Dev Biol 7:115. 2007
    ..We have now used the sea cucumber Holothuria glaberrima to address this question.
  12. ncbi Identification of nerve plexi in connective tissues of the sea cucumber Holothuria glaberrima by using a novel nerve-specific antibody
    Carlos A Díaz-Balzac
    Biology Department, University of Puerto Rico, Rio Piedras Campus, Rio Piedras, Puerto Rico 00931
    Biol Bull 213:28-42. 2007
    ..We have now produced a monoclonal antibody (RN1) that labels a nervous system component of the sea cucumber Holothuria glaberrima. Western blots show that our antibody recognizes a major band of 66 kDa and a minor band of 53 kDa...
  13. pmc Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima
    José E San Miguel-Ruiz
    Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico
    BMC Dev Biol 9:3. 2009
    ..Echinoderms, with their amazing regenerative capacities could serve as model systems; however, very few studies have been done to study the regeneration of their nervous system...
  14. ncbi Immune-related genes associated with intestinal tissue in the sea cucumber Holothuria glaberrima
    Francisco Ramírez-Gómez
    Department of Biology, University of Puerto Rico, P O Box 23360, UPR Station, Rio Piedras, San Juan, PR 00931 3360
    Immunogenetics 60:57-71. 2008
    ..sequence tags (ESTs) from three cDNA libraries of normal and regenerating intestinal tissue of the sea cucumber Holothuria glaberrima and found 22 putative immune-related genes...
  15. ncbi Spherulocytes in the echinoderm Holothuria glaberrima and their involvement in intestinal regeneration
    JOSE E GARCIA-ARRARAS
    Biology Department, University of Puerto Rico, Rio Piedras, Puerto Rico
    Dev Dyn 235:3259-67. 2006
    The holothuroid echinoderm Holothuria glaberrima can regenerate its intestine after a process of evisceration. Spherule-containing cells, the spherulocytes, appear to be associated with intestinal regeneration...
  16. ncbi Myogenesis during holothurian intestinal regeneration
    Gisela Murray
    Biology Department, University of Puerto Rico, 00931, Rio Piedras, PR, 00931, Puerto Rico
    Cell Tissue Res 318:515-24. 2004
    ..We are interested in intestinal regeneration in the sea cucumber, Holothuria glaberrima, and focus here on the regeneration of intestinal muscle components...
  17. pmc Distinct profiles of expressed sequence tags during intestinal regeneration in the sea cucumber Holothuria glaberrima
    Carmencita Rojas-Cartagena
    Department of Biology, Rio Piedras Campus, San Juan, Puerto Rico
    Physiol Genomics 31:203-15. 2007
    ..The sea cucumber Holothuria glaberrima represents an excellent model to dissect and characterize the molecular events during intestinal ..
  18. pmc LPS-induced genes in intestinal tissue of the sea cucumber Holothuria glaberrima
    Francisco Ramírez-Gómez
    Department of Biology, University of Puerto Rico, Rio Piedras, San Juan, Puerto Rico
    PLoS ONE 4:e6178. 2009
    ..Our study employs a non-conventional model, the echinoderm Holothuria glaberrima, to identify intestinal molecules expressed after an immune challenge presented by an intra-coelomic ..
  19. doi Iamia majanohamensis gen. nov., sp. nov., an actinobacterium isolated from sea cucumber Holothuria edulis, and proposal of Iamiaceae fam. nov
    Midori Kurahashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Int J Syst Evol Microbiol 59:869-73. 2009
    A novel, Gram-positive bacterial strain, F12(T), was isolated from the abdominal epidermis of a sea cucumber, Holothuria edulis, collected from seawater off the coast of Japan...
  20. doi A novel stiffening factor inducing the stiffest state of holothurian catch connective tissue
    Akira Yamada
    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, Hyogo 651 2492, Japan
    J Exp Biol 213:3416-22. 2010
    ..A stiffening protein, tensilin, has been isolated from some sea cucumbers (Cucumaria frondosa and Holothuria leucospilota)...
  21. doi Effect of diel activity patterns and harvesting pressure on the diversity and biomass of sea cucumbers in Marovo Lagoon, Solomon Islands
    Christine Buckius
    Centre for Water Studies, University of Queensland, St Lucia, QLD, Australia
    Environ Manage 45:963-73. 2010
    ..Day time and nocturnal transects revealed a mean abundance of 32.4 (SD = 5.3) low value species per ha (e.g. Holothuria atra, H. edulis, H. coluber and Thelenota anax) and 15.2 (SD = 2.7) high value species per ha (e.g. H...
  22. doi AChE and EROD activities in two echinoderms, Holothuria leucospilota and Holoturia atra (Holothuroidea), in a coral reef (Reunion Island, South-western Indian Ocean)
    Joanna Kolasinski
    Laboratoire d Ecologie Marine, Universite de la Reunion, La Reunion, France
    J Environ Sci Health A Tox Hazard Subst Environ Eng 45:699-708. 2010
    AChE and EROD activities were investigated in two holothurian species, Holothuria leucospilota and Holoturia atra, from a tropical coral reef...
  23. ncbi Molecular phylogeny of coral-reef sea cucumbers (Holothuriidae: Aspidochirotida) based on 16S mitochondrial ribosomal DNA sequence
    Alexander M Kerr
    Department of Ecology and Evolutionary Biology, Osborn Zoölogical Laboratories, Yale University, New Haven, CT 06520, U S A
    Mar Biotechnol (NY) 7:53-60. 2005
    ..Most notably, the genus Holothuria appears paraphyletic...
  24. doi Molecular systematics of the genus Holothuria in the Mediterranean and Northeastern Atlantic and a molecular clock for the diversification of the Holothuriidae (Echinodermata: Holothuroidea)
    Giomar Helena Borrero-Pérez
    Departamento de Ecología e Hidrología, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Mol Phylogenet Evol 57:899-906. 2010
    This work investigates the systematics of the genus Holothuria in the Mediterranean Sea and Northeastern Atlantic in the light of a wider molecular phylogenetic hypothesis of Holothuriidae, and it also provides a time-scale for the family ..
  25. ncbi [The echinoderms (Echinodermata) from El Salvador]
    José Enrique Barraza
    Ministerio de Medio Ambiente y Recursos Naturales, Dirección de Patrimonio Natural Col y Calle Las Mercedes, Plantel ISTA, San Salvador, El Salvador
    Rev Biol Trop 53:139-46. 2005
    ..A total of 37 species and six genera are reported. The most abundant echinoderms in rocky shores were: Phataria unifascialis, Echinometra vanbrunti, Holothuria kefersteini, as well as Astropecten armatus in soft bottoms.
  26. ncbi [Antithrombotic mechanisms of holothurian glycosaminoglycan extracted from sea cucumber]
    Wei zhang Shen
    Shanghai Institute of Haematology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China
    Zhonghua Xue Ye Xue Za Zhi 27:579-83. 2006
    ..To investigate the antithrombotic mechanisms of holothurian glycosaminoglycan (GAG) extracted from sea cucumber...
  27. ncbi Engagement of the periesophageal ring during Holothuria polii response to erythrocyte injection
    G D'Ancona Lunetta
    Istituto di Istologia ed Embrologia, Facolta di Scienze, MM FF NN, Universita di Palermo, Italy
    Eur J Histochem 46:185-94. 2002
    In Holothuria polii, the periesophageal ring is an important organ supplying spherule cells after stimulation with foreign material...
  28. ncbi Destruction of a Holothuria scabra population by overfishing at Abu Rhamada Island in the Red Sea
    Mohamed Hamza Hasan
    National Institute of Oceanography and Fisheries, Red Sea and Gulfs of Suez and Aqaba Branch, P O Box 182 Suez, Egypt
    Mar Environ Res 60:489-511. 2005
    Populations of Holothuria scabra at Abu Rhamada Island were investigated during 52 months, from July 1999 to October 2003...
  29. ncbi Diversity and function of aerobic culturable bacteria in the intestine of the sea cucumber Holothuria leucospilota
    Xiaochi Zhang
    Graduate School of Science and Technology, Nagasaki University, Nagasaki 852 8521, Japan
    J Gen Appl Microbiol 58:447-56. 2012
    ..Here, we isolated 141 bacterial strains under aerobic conditions using various media from the intestine of Holothuria leucospilota, a common sea cucumber in Japanese warm waters...
  30. ncbi Extracellular matrix remodeling and metalloproteinase involvement during intestine regeneration in the sea cucumber Holothuria glaberrima
    José L Quiñones
    Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico 00931, USA
    Dev Biol 250:181-97. 2002
    The sea cucumber, Holothuria glaberrima, has the capacity to regenerate its internal organs...
  31. pmc Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers
    Lan Luo
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
    Mar Drugs 11:399-417. 2013
    ..activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis...
  32. pmc High-value components and bioactives from sea cucumbers for functional foods--a review
    Sara Bordbar
    Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
    Mar Drugs 9:1761-805. 2011
    ....
  33. doi Kinetics and thermodynamics of glycans and glycoproteins binding to Holothuria scabra lectin: a fluorescence and surface plasmon resonance spectroscopic study
    Nagaraj M Gowda
    Department of Anesthesiology and Critical Care Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Fluoresc 23:1147-55. 2013
    b>Holothuria scabra produces a monomeric lectin (HSL) of 182 kDa. HSL showed strong antibacterial activity and induced bacterial agglutination under in vitro conditions, indicating its role in animals' innate immune responses...
  34. ncbi Telomeric localization of the vertebrate-type hexamer repeat, (TTAGGG)n, in the wedgeshell clam Donax trunculus and other marine invertebrate genomes
    Miroslav Plohl
    Department of Molecular and Cell Biology, Institut de Biologia Molecular de Barcelona, CSIC, E 08034 Barcelona, Spain
    J Biol Chem 277:19839-46. 2002
    ..and other marine invertebrates, genomic DNA from the mussel Mytilus galloprovincialis and the echinoderm Holothuria tubulosa was also analyzed...
  35. pmc Proteases from the regenerating gut of the holothurian Eupentacta fraudatrix
    Nina E Lamash
    A V Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
    PLoS ONE 8:e58433. 2013
    ..The role of the detected proteases in the regeneration processes of holothurians is discussed...
  36. doi Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract
    W A J P Wijesinghe
    School of Marine Biomedical Sciences, Jeju National University, Jeju 690 756, Republic of Korea
    Food Chem 139:326-31. 2013
    ..In this study, edible sea cucumber Holothuria edulis was evaluated for its in vitro anticancer potential...
  37. doi Antioxidant and cytotoxic properties of two sea cucumbers, Holothuria edulis lesson and Stichopus horrens Selenka
    O Y Althunibat
    Department of Biomedical Science, International Islamic University, Kuantan, Pahang, Malaysia
    Acta Biol Hung 64:10-20. 2013
    ..the antioxidant and cytotoxic properties of aqueous and organic extracts from two sea cucumber species, Holothuria edulis Lesson (Holothuriidae) and Stichopus horrens Selenka (Stichopodidae)...
  38. doi Discovery and widespread occurrence of polyhalogenated 1,1'-dimethyl-2,2'-bipyrroles (PDBPs) in marine biota
    Carolin Hauler
    University of Hohenheim, Institute of Food Chemistry, Garbenstraße 28, 70599 Stuttgart, Germany
    Environ Pollut 178:329-35. 2013
    ..Thirteen of these new PDBPs were also detected in an Australian sea cucumber (Holothuria sp.)...
  39. ncbi Lipopolysaccharides induce intestinal serum amyloid A expression in the sea cucumber Holothuria glaberrima
    Pedro G Santiago-Cardona
    Department of Biology, University of Puerto Rico, UPR Station, PR 00931 3360, Rio Piedras, Puerto Rico
    Dev Comp Immunol 27:105-10. 2003
    ..previously characterized the first invertebrate homolog of serum amyloid A (SAA) proteins in the sea cucumber Holothuria glaberrima, where its expression is associated with intestinal regeneration, suggesting a possible involvement ..
  40. ncbi Characterization of the adhesive from cuvierian tubules of the sea cucumber Holothuria forskali (Echinodermata, Holothuroidea)
    Sonia DeMoor
    Marine Biology Laboratory, University of Mons Hainaut, 6 Avenue du Champ de Mars, B 7000 Mons, Belgium
    Mar Biotechnol (NY) 5:45-57. 2003
    ..The cellular origin and composition of the Cuvierian tubule adhesive were investigated in the species Holothuria forskali by studying prints left on the substratum after mechanical detachment of the tubule...
  41. doi Screening of microbial contamination and antimicrobial activity of sea cucumber Holothuria polii
    Nahla E E Omran
    1Invertebrate Unit, Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
    Toxicol Ind Health 29:944-54. 2013
    Microbiological studies were carried out on microbial contamination and antimicrobial activity of sea cucumber Holothuria polii collected from Mediterranean Sea at Abu-kir shore of Alexandria, Egypt...
  42. ncbi The spherule cells of Holothuria polii Delle Chiaie, 1823 (Aspidochirota, Holothuroidea) during brown body formation: an ultrastructural study
    P Pagliara
    Department of Biology, University of Lecce, Italy
    J Submicrosc Cytol Pathol 35:295-301. 2003
    ..Morphological modifications of spherule cells were studied in Holothuria polii following the induction of brown body formation by intracoelomic injection of sheep erythrocytes...
  43. doi The morphology of the digestive tract and respiratory organs of the holothurian Cladolabes schmeltzii (Holothuroidea, Dendrochirotida)
    Ya O Kamenev
    AV Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
    Tissue Cell 45:126-39. 2013
    ..The coelomic epithelium of the intestine and the respiratory trees consists of peritoneal and myoepithelial cells...
  44. doi Bioactive compounds, antioxidant potential, and hepatoprotective activity of sea cucumber (Holothuria atra) against thioacetamide intoxication in rats
    Amr Y Esmat
    Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
    Nutrition 29:258-67. 2013
    The identification of the active phenolic compounds in the mixed extract of sea cucumber (Holothuria atra) body wall by high-performance liquid chromatography and an assessment of its hepatoprotective activity against thioacetamide-..
  45. pmc Gene expression profiling of intestinal regeneration in the sea cucumber
    Pablo A Ortiz-Pineda
    University of Puerto Rico, Rio Piedras, Department of Biology, San Juan, PR, USA
    BMC Genomics 10:262. 2009
    ..For the last decade, our laboratory has been using the sea cucumber Holothuria glaberrima to dissect the cellular and molecular events that allow for such amazing regenerative processes...
  46. doi Bioactivity as an options value of sea cucumbers in the Egyptian Red Sea
    A J Lawrence
    Department of Life Sciences, University of the West Indies, St Augustine, Trinidad and Tobago
    Conserv Biol 24:217-25. 2010
    ..All habitat types were surveyed within these regions. We found 22 species of sea cucumber of which two, Holothuria fuscogilva and Holothuria flavomaculata, were recorded in Egypt for the first time...
  47. doi Spermatogenesis and chromatin condensation in male germ cells of sea cucumber Holothuria leucospilota (Clark, 1920)
    A Thongkukiatkul
    Department of Biology, Faculty of Science, Burapha University, Chonburi 20131, Thailand
    Tissue Cell 40:167-75. 2008
    Male germ cells in the testis of Holothuria leucospilota can be divided into 12 stages based on ultrastructure and patterns of chromatin condensation. The spermatogonium (Sg) is a spherical-shaped cell with a diameter of about 6.5-7microm...
  48. pmc Qualitative and quantitative saponin contents in five sea cucumbers from the Indian ocean
    Séverine Van Dyck
    Marine Biology Laboratory, University of Mons, 20 Place du Parc, B 7000 Mons, Belgium
    Mar Drugs 8:173-89. 2010
    ..The smallest number of saponins was observed in Holothuria atra, which contained a total of four congeners, followed by Holothuria leucospilota, Pearsonothuria graeffei ..
  49. ncbi Antifungal active triterpene glycosides from sea cucumber Holothuria scabra
    Hua Han
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    Yao Xue Xue Bao 44:620-4. 2009
    To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra...
  50. doi Euzebya tangerina gen. nov., sp. nov., a deeply branching marine actinobacterium isolated from the sea cucumber Holothuria edulis, and proposal of Euzebyaceae fam. nov., Euzebyales ord. nov. and Nitriliruptoridae subclassis nov
    Midori Kurahashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Int J Syst Evol Microbiol 60:2314-9. 2010
    ..actinobacterial strain, designated F10(T), was isolated from the abdominal epidermis of a sea cucumber, Holothuria edulis, collected in seawater off the coast of Japan...
  51. pmc Changes in holothurian coelomocyte populations following immune stimulation with different molecular patterns
    Francisco Ramírez-Gómez
    Department of Biology, University of Puerto Rico, P O Box 23360, UPR Station, Rio Piedras, San Juan, PR 00931 3360, USA
    Fish Shellfish Immunol 29:175-85. 2010
    ..In the sea cucumber Holothuria glaberrima, four different coelomocyte types were readily distinguished using morphological, histochemical and ..
  52. pmc Cell dedifferentiation and epithelial to mesenchymal transitions during intestinal regeneration in H. glaberrima
    JOSE E GARCIA-ARRARAS
    Biology Department, University of Puerto Rico, Rio Piedras 00931, Puerto Rico
    BMC Dev Biol 11:61. 2011
    ..We have previously used several cellular markers to characterize the cells involved in the regeneration of the intestine in the sea cucumber Holothuria glaberrima.
  53. doi Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue
    Yuki Iwayama
    Department of Applied Bioorganic Chemistry, Gifu University, 1 1 Yanagido, Gifu shi, Gifu 501 1193, Japan
    Chem Commun (Camb) 47:9726-8. 2011
    The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time...
  54. doi Genetic barcoding of commercial Bêche-de-mer species (Echinodermata: Holothuroidea)
    Sven Uthicke
    Australian Institute of Marine Science, PMB No 3, Townsville, Qld 4810, Australia Department of Anatomy and Histology, F13, University of Sydney, Sydney, NSW 2006, Australia Ecomar Laboratory, Universite de la Reunion, Saint Denis 97715, Reunion, France
    Mol Ecol Resour 10:634-46. 2010
    ..Sequence data showed that large (deep) and small (shallow) morphotypes of Holothuria atra are the same species, but suggested potential cryptic species within this taxon...
  55. doi The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish
    Séverine Van Dyck
    University of Mons UMONS, Marine Biology Laboratory, 6 Avenue du Champs de Mars, B 7000 Mons, Belgium
    J Exp Biol 214:1347-56. 2011
    ..In particular, Holothuria forskali contains 26 saponins in its Cuvierian tubules and 12 in its body wall...
  56. pmc Localization of secondary metabolites in marine invertebrates: contribution of MALDI MSI for the study of saponins in Cuvierian tubules of H. forskali
    Séverine Van Dyck
    Laboratoire de Biologie Marine, Universite de Mons, Mons, Belgium
    PLoS ONE 5:e13923. 2010
    ..In the present study, the precise localization of saponins in the Ct of Holothuria forskali is investigated...
  57. doi Chemical composition and nutritional quality of sea cucumbers
    Jing Wen
    Key Laboratory of Marine Bio resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
    J Sci Food Agric 90:2469-74. 2010
    ..and nutritional quality of eight common sea cucumbers (Stichopus herrmanni, Thelenota ananas, Thelenota anax, Holothuria fuscogilva, Holothuria fuscopunctata, Actinopyga mauritiana, Actinopyga caerulea and Bohadschia argus) were ..
  58. ncbi [Distribution and density of two holothurian species in Cubagua Island, Venezuela]
    Alejandro Tagliafico
    Escuela de Ciencias Aplicadas del Mar, Núcleo de Nueva Esparta, Universidad de Oriente, Boca de Rio, Isla de Margarita, Venezuela
    Rev Biol Trop 59:843-52. 2011
    ..the distribution, abundance and population structure of two commercial holothurians Isostichopus badionotus and Holothuria mexicana in Cubagua Island shores. A total of 52 stations were studied around the island during the year 2008...
  59. doi Genetic diversity and connectivity remain high in Holothuria polii (Delle Chiaje 1823) across a coastal lagoon-open sea environmental gradient
    Carlos Vergara-Chen
    Departamento de Ecología e Hidrología, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Genetica 138:895-906. 2010
    ..This study investigates the genetic structure of Holothuria polii at a micro-geographic scale across the Mar Menor coastal lagoon and nearby marine areas, estimating the ..
  60. doi Organization of glial cells in the adult sea cucumber central nervous system
    Vladimir S Mashanov
    Department of Biology, University of Puerto Rico, Rio Piedras, PR 00936 8377, Puerto Rico
    Glia 58:1581-93. 2010
    ..confocal, and electron microscopy, we demonstrate here that the central nervous system of the sea cucumber Holothuria glaberrima possesses a major non-neuronal cell type, which shares striking similarities with the radial glia of ..
  61. doi A new endosymbiotic bivalve (Heterodonta: Galeommatoidea), from Pacific holothurians
    G A Bristow
    Department of Biology, University of Bergen, N 5020 Bergen, Norway
    J Parasitol 96:532-4. 2010
    A fourth known species of Entovalva (Mollusca: Galeommatoidea), found in the esophagus of Holothuria spinifera and Holothuria leucospilota from Nha Trang Bay, Viet Nam, is described...
  62. doi A first total synthesis of ganglioside HLG-2
    Yuki Iwayama
    Department of Applied Bioorganic Chemistry, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu shi, Gifu, Japan
    Chemistry 15:4637-48. 2009
    ..A first synthesis of the neuritegenic ganglioside HLG-2, which was identified in extracts of the sea cucumber Holothuria leucospilota, is described...
  63. ncbi Constituents of Holothuroidea, 18. Isolation and structure of biologically active disialo- and trisialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:1293-8. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  64. ncbi Constituents of holothuroidea, 16. Determination of Absolute configuration of the branched methyl group in ante-iso type side chain moiety on long chain base of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:1333-4. 2005
    ..side chain moiety on the long chain base of glucocerebroside, HLC-2-A, which was isolated from the sea cucumber Holothuria leucospilota was determined...
  65. ncbi In vitro decondensation of the sperm chromatin in Holothuria tubulosa (sea cucumber) not affecting proteolysis of basic nuclear proteins
    Luis J Del Valle
    Center de Biotecnología Molecular, Departament d Enginyeria Quimica, EUETIB, Consorci Escola Industrial de Barcelona, Universitat Politecnica de Catalunya, 08036 Barcelona, Spain
    Dev Growth Differ 47:333-42. 2005
    ..We have studied the presence of this proteolytic activity in Holothuria tubulosa (sea cucumber) and its possible relationship with sperm nuclei decondensation...
  66. ncbi Symbionts of holothurians from south Vietnam: intra- and interspecific interactions
    S A Lyskin
    Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr 33, Moscow, 119071, Russia
    Dokl Biol Sci 401:116-9. 2005
  67. ncbi Constituents of Holothuroidea, 15. Isolation of ante-iso type regio-isomer on long chain base moiety of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:788-91. 2005
    ..and ante-iso isomers, from the less polar lipid fraction of a chloroform/methanol extract of the sea cucumber Holothuria leucospilota...
  68. ncbi A simple enzymatic method for examining calcite ossicles of Echinodermata
    C G Tiago
    Centro de Biologia Marinha, Universidade de Sao Paulo, São Sebastião, Brazil
    J Microsc 218:240-6. 2005
    ..method was tested on fragments of body tissues from three species in three different orders of holothurians: Holothuria grisea Selenka, 1867 (Aspidochirotida), Duasmodactyla seguroensis (Deichmann, 1930) (Dendrochirotida) and ..
  69. ncbi Holothurins B(2), B(3), and B(4), new triterpene glycosides from mediterranean sea cucumbers of the genus holothuria
    Alexandra S Silchenko
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russian Federation
    J Nat Prod 68:564-7. 2005
    Triterpene glycosides of three species of the Mediterranean sea cucumbers Holothuria polii, Holothuria tubulosa, and Holothuria sp. were studied...
  70. ncbi [Clinical study on the antithrombotic effects of Holothuria ldeucospilota acidic mucopolysaccharide]
    X Wang
    Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025
    Zhonghua Xue Ye Xue Za Zhi 18:457-9. 1997
    To study the antithrombotic effects of Holothuria Ldeucospilota Acidic Mucopolysaccharide (HLAM).
  71. ncbi DNA integrity determination in marine invertebrates by Fast Micromethod
    Zeljko Jaksić
    Laboratory for Marine Molecular Toxicology, Center for Marine Research, Ruder Boskovic Institute, G Paliage 5, HR 52210 Rovinj, Croatia
    Aquat Toxicol 65:361-76. 2003
    ..5. The induction of DNA damage and loss of DNA integrity was measured in native DNA isolated from cotton-spinner Holothuria tubulosa, marine sponge Suberites domuncula cells and mussel M. galloprovincialis gills homogenate...
  72. ncbi An annotated description of shallow water holothurians (Echinodermata: Holothuroidea) from Cayos Cochinos, Honduras
    Carlos Roberto Hasbún
    Dept of Biological Sciences, University of Hull, Kingston upon Hull, HU6 7RX, UK
    Rev Biol Trop 50:669-78. 2002
    ..to a single order (Aspidochirotida) and two families: Stichopodidae (Isostichopus badionotus) and Holothuriidae (Holothuria mexicana, H. thomasi, H. arenicola and Actinopyga agassizi)...
  73. pmc A comparison between two brine shrimp assays to detect in vitro cytotoxicity in marine natural products
    José Luis Carballo
    Instituto de Ciencias del Mar y Limnologia, UNAM, Estación Mazatlán, Apartado Postal 811, Mazatlan 82000, Mexico
    BMC Biotechnol 2:17. 2002
    ..However, we think that it is necessary to evaluate the suitability of the brine shrimp methods before they are used as a general bio-assay to test natural marine products for pharmacological activity...
  74. ncbi Regeneration of the enteric nervous system in the sea cucumber Holothuria glaberrima
    J E Garcia-Arraras
    Department of Biology, University of Puerto Rico, Rio Piedras Campus, 00931, USA
    J Comp Neurol 406:461-75. 1999
    ..and ultrastructural studies to describe the regeneration of the enteric nervous system in the sea cucumber Holothuria glaberrima...
  75. ncbi Identification of the novel 7-methyl-6-octadecenoic acid in Holothuria mexicana
    N M Carballeira
    Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico 00931
    J Nat Prod 59:1076-8. 1996
    The phospholipid fatty acid composition of Holothuria mexicana was investigated, and the novel 7-methyl-6-octadecenoic acid was identified...
  76. ncbi Galanin-like immunoreactivity in the sea cucumber Holothuria glaberrima
    L Díaz-Miranda
    Department of Biology, University of Puerto Rico, Rio Piedras Campus, Rio Piedras, P R 00931, Puerto Rico
    Cell Tissue Res 286:385-91. 1996
    ..In this study, galanin-like immunoreactivity was detected in an invertebrate, the sea cucumber Holothuria glaberrima...
  77. ncbi Indigenous community-based fisheries in Australia
    Jennifer Carter
    Department of Environmental and Planning Studies, Faculty of Arts and Social Sciences, University of the Sunshine Coast, Maroochydore DC, 4556 QLD, Australia
    J Environ Manage 85:866-75. 2007
    The commercial sea cucumber species known as Sandfish (Holothuria scabra) occurs intertidally and subtidally in the Northern Territory of Australia, on or adjacent to Aboriginal land...
  78. ncbi Structure and cytotoxicity of a new lanostane-type triterpene glycoside from the sea cucumber Holothuria hilla
    Jun Wu
    Research Center for Marine Drugs, College of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai, 200433, P R China
    Chem Biodivers 3:1249-54. 2006
    A new triterpene glycoside, hillaside C (1), was isolated from the sea cucumber Holothuria hilla Lesson, which is found in the South China Sea, and its structure has been elucidated by spectral analysis (ESI-MS and NMR) and chemical ..
  79. doi Regulation of sperm flagellar motility activation and chemotaxis caused by egg-derived substance(s) in sea cucumber
    Masaya Morita
    Tropical Biosphere Research Center, Sesoko Station, University of the Ryukyus, Sesoko, Motobu, Okinawa, Japan
    Cell Motil Cytoskeleton 66:202-14. 2009
    The sea cucumber Holothuria atra is a broadcast spawner. Among broadcast spawners, fertilization occurs by means of an egg-derived substance(s) that induces sperm flagellar motility activation and chemotaxis...
  80. doi Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga
    Wei Hua Yuan
    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Planta Med 75:647-53. 2009
    ..2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark...
  81. ncbi The effect of sea cucumber Holothuria tubulosa (G., 1788) on nutrient and sediment of Aegean Sea shores
    Dilek Işgören Emiroğlu
    Department of Aquaculture, Faculty of Fisheries, Ege University, 35100 Bornova, Izmir, Turkiye
    Pak J Biol Sci 10:586-9. 2007
    The effects of sea cucumber, Holothuria tubulosa, on sediment of hypereutrophic conditions were investigated. Research was designed as two groups with 3 replicates...
  82. doi Elucidation of molecular diversity and body distribution of saponins in the sea cucumber Holothuria forskali (Echinodermata) by mass spectrometry
    Séverine Van Dyck
    Marine Biology Laboratory, University of Mons Hainaut, Mons, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 152:124-34. 2009
    ..We investigated the complex saponin mixture extracted from the common Mediterranean species Holothuria forskali...
  83. ncbi [Complexation between triterpene glycosides of holothurians and cholesterol is the basis of lipid-saponin carriers of subunit protein antigens]
    A N Mazeĭka
    Biofizika 53:826-35. 2008
    ..Thus, the possibility of the formation of a new type of antigen carries on the basis of marine triterpene glycosides was proved...
  84. doi The plutonium isotopic composition of marine biota on Enewetak Atoll: a preliminary assessment
    Terry F Hamilton
    Center for Accelerator Mass Spectrometry, CMELS, Lawrence Livermore National Laboratory, P O Box 808, Livermore, CA 94551 0808, USA
    J Environ Monit 10:1134-8. 2008
    ..samples of giant clam (Tridacna gigas and Hippopus hippopus), a top snail (Trochus nilaticas) and sea cucumber (Holothuria atra) collected from different locations around Enewetak Atoll...
  85. ncbi Gene flow and population history in high dispersal marine invertebrates: mitochondrial DNA analysis of Holothuria nobilis (Echinodermata: Holothuroidea) populations from the Indo-Pacific
    S Uthicke
    Australian Institute of Marine Science, PMB No 3, Townsville, Queensland 4810, Australia
    Mol Ecol 12:2635-48. 2003
    The sea cucumber, Holothuria nobilis, has a long-lived planktotrophic larvae, and previous allozyme surveys have suggested that high dispersal is realized. In contrast, recent ecological studies indicate that dispersal is low...
  86. ncbi Two new triterpene glycosides from the Vietnamese sea cucumber Holothuria scabra
    Nguyen Hai Dang
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 30:1387-91. 2007
    ..glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS)...
  87. ncbi Ontogeny of the holothurian larval nervous system: evolution of larval forms
    Cory D Bishop
    Kewalo Marine Laboratory, University of Hawaii, Honolulu, HI, USA
    Dev Genes Evol 217:585-92. 2007
    ..apomorphic features, we have examined the ontogeny of the dipleurula-like auricularia larva of the sea cucumber, Holothuria atra...
  88. ncbi Pharmacological action of the heptapeptide GFSKLYFamide in the muscle of the sea cucumber Holothuria glaberrima (Echinodermata)
    L Díaz-Miranda
    Department of Biology, University of Puerto Rico, Rio Piedras 00931
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 110:171-6. 1995
    ..Our investigation provides additional evidence indicating that GFSKLYFa might be a neurotransmitter acting at the neuromuscular junctions of the sea cucumber Holothuria glaberrima.
  89. ncbi Hillasides A and B, two new cytotoxic triterpene glycosides from the sea cucumber Holothuria hilla Lesson
    Jun Wu
    College of Pharmacy, Research Center for Marine Drugs, Second Military Medical University, Shanghai, China
    J Asian Nat Prod Res 9:609-15. 2007
    ..hilla Lesson, together with one known glycoside holothuria B (3). Their structures were deduced by extensive spectral analysis and chemical evidences...
  90. ncbi Interspecies differences in DNA single strand breaks caused by benzo(a)pyrene and marine environment
    Nevenka Bihari
    Institute Ruder Boskovic, Center for Marine Research, G Paliaga 5, Rovinj HR, 52210 Rovinj, Croatia
    Mutat Res 552:209-17. 2004
    ..painted comber Serranus scriba, blue mussel Mytilus galloprovincialis, spiny crab Maja crispata and sea cucumber Holothuria tubulosa as well as in 10 microg/g benzo(a)pyrene (BaP) treated mosquito fish, blue mussel and spiny crab was ..
  91. ncbi [Screening of bioactive constituents from sea cucumber Holothuria nobilis using conidia of Pyricularia oryzae]
    Jia Jia Zhang
    Zhejiang Pharmaceutical College, Ningbo 315200, China
    Zhong Yao Cai 31:1001-3. 2008
    To study the bioactive triterpene glycosides from sea cucumber Holothuria nobilis.
  92. ncbi Cellular mechanisms of intestine regeneration in the sea cucumber, Holothuria glaberrima Selenka (Holothuroidea:Echinodermata)
    J E Garcia-Arraras
    Department of Biology, University of Puerto Rico, Rio Piedras 00931
    J Exp Zool 281:288-304. 1998
    ..We have studied this process in the sea cucumber Holothuria glabberrima by describing the spatial and temporal pattern of cellular events that occur during intestine ..
  93. ncbi Exogonadal oogenesis in a temperate holothurian
    Jean François Hamel
    Society for the Exploration and Valuing of the Environment SEVE, 21 Phils Hill Road, Portugal Cove St Philips, Newfoundland A1M 2B7, Canada
    Biol Bull 213:101-9. 2007
    ..The possibility that exogonadal oogenesis is attributable to anthropogenic disturbances should be investigated even though some of the affected specimens originate from presumably pristine locations...
  94. ncbi Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro
    Weiwei Zhang
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    Cancer Biol Ther 8:1489-99. 2009
    Acidic mucopolysaccharide from Holothuria Leucospilota (HS) may affect some steps in metastasis cascade...
  95. ncbi [Chemical constituents from sea cucumber Holothuria nobilis]
    Jia Jia Zhang
    Zhejiang Pharmaceutical College, Ningbo 315200, China
    Zhong Yao Cai 31:538-9. 2008
    To study the chemical constituents of sea cucumber Holothuria hilla L..
  96. ncbi Constituents of Holothuroidea, 17. Isolation and structure of biologically active monosialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:982-7. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  97. ncbi Determination of steryl sulphates in invertebrate tissue by liquid chromatography-tandem mass spectrometry
    Renato R Neto
    Organic Biogeochemistry Group, Oceanography Laboratories, Department of Earth and Ocean Sciences, University of Liverpool, Liverpool, L69 3GP, UK
    Anal Bioanal Chem 383:938-46. 2005
    ..98). It is suggested that the structure elucidation of steryl sulphates is best achieved in CID positive APCI mode, whereas their quantification should be carried out using negative APCI...