Genomes and Genes
Summary: A large order of insects comprising the butterflies and moths.
Publications301 found, 100 shown here
- Toward reconstructing the evolution of advanced moths and butterflies (Lepidoptera: Ditrysia): an initial molecular studyJerome C Regier
Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
BMC Evol Biol 9:280. 2009In the mega-diverse insect order Lepidoptera (butterflies and moths; 165,000 described species), deeper relationships are little understood within the clade Ditrysia, to which 98% of the species belong...
- Extreme diversity of tropical parasitoid wasps exposed by iterative integration of natural history, DNA barcoding, morphology, and collectionsM Alex Smith
The Biodiversity Institute of Ontario, University of Guelph, Guelph Ontario, N1G 2W1 Canada
Proc Natl Acad Sci U S A 105:12359-64. 2008....
- Candidate chemosensory ionotropic receptors in a LepidopteraV Olivier
INRA, UMR 1272 INRA UPMC PISC Physiologie de l Insecte Signalisation et Communication, Route de Saint Cyr, Versailles, France
Insect Mol Biol 20:189-99. 2011..Our data suggest that we identified members of the insect IR chemosensory receptor family in S. littoralis and we report here the first demonstration of IR expression in Lepidoptera.
- RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental designOlle Terenius
Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden
J Insect Physiol 57:231-45. 2011..However, in Lepidoptera (moths and butterflies) RNAi has many times proven to be difficult to achieve...
- Mitochondrial genome sequence and expression profiling for the legume pod borer Maruca vitrata (Lepidoptera: Crambidae)Venu M Margam
Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America
PLoS ONE 6:e16444. 2011..14,054 bp near complete sequencing of the mitochondrial genome of the legume pod borer (LPB), Maruca vitrata (Lepidoptera: Crambidae), which we subsequently used to estimate divergence and relationships within the lepidopteran ..
- Can deliberately incomplete gene sample augmentation improve a phylogeny estimate for the advanced moths and butterflies (Hexapoda: Lepidoptera)?Soowon Cho
Department of Entomology, University of Maryland, College Park, MD 20742, USA
Syst Biol 60:782-96. 2011..poorly understood deeper relationships in the large clade Ditrysia ( > 150,000 species) of the insect order Lepidoptera (butterflies and moths)...
- DNA barcodes for 1/1000 of the animal kingdomPaul D N Hebert
Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
Biol Lett 6:359-62. 2010This study reports DNA barcodes for more than 1300 Lepidoptera species from the eastern half of North America, establishing that 99.3 per cent of these species possess diagnostic barcode sequences...
- Structural characteristics and phylogenetic analysis of the mitochondrial genome of the sugarcane borer, Diatraea saccharalis (Lepidoptera: Crambidae)Weiwei Li
Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu, PR China
DNA Cell Biol 30:3-8. 2011..The complete mitochondrial sequences of D. saccharalis reported in this study can provide useful data in analyzing divergence of lepidopteran insects and in developing DNA-based diagnoses and genetic makers...
- The complete mitochondrial genome of Spilonota lechriaspis Meyrick (Lepidoptera: Tortricidae)Jin Liang Zhao
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210046, China
Mol Biol Rep 38:3757-64. 2011We determined the nucleotide sequence of the mitochondrial genome (mtgenome) of Spilonota lechriaspis Meyrick (Lepidoptera: Tortricidae)...
- A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensisXuebin Zhang
Biological Targets Inc, Dallas, TX 75235, USA
Proc Natl Acad Sci U S A 103:9897-902. 2006..The discovery of a toxin-induced cell death pathway specifically linked to BT-R(1) in insect cells should provide insights into how insects evolve resistance to Bt and into the development of new, safer insecticides...
- Identification of receptors of main sex-pheromone components of three Lepidopteran speciesHidefumi Mitsuno
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Eur J Neurosci 28:893-902. 2008....
- The complete mitochondrial genome of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae)Fang Liao
1 College of Life Sciences, Nankai University, Tianjin 300071, China
Int J Biol Sci 6:172-86. 2010The complete mitochondrial genome (mitogenome) of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae) was determined. The genome is a circular molecule 15 481 bp long...
- DNA barcoding the geometrid fauna of Bavaria (Lepidoptera): successes, surprises, and questionsAxel Hausmann
Entomology Department, Zoological Collection of the State of Bavaria, Munich, Germany
PLoS ONE 6:e17134. 2011..The present study provides a comprehensive DNA barcode library for the Geometridae, one of the most diverse of insect families...
- Parallel evolution of Bacillus thuringiensis toxin resistance in lepidopteraSimon W Baxter
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Genetics 189:675-9. 2011..Here we report genetic mapping of a membrane transporter (ABCC2) to a locus controlling Bt Cry1Ac toxin resistance in two lepidopterans, implying that this protein plays a critical role in Bt function...
- The complete mitochondrial genome of the yellow coaster, Acraea issoria (Lepidoptera: Nymphalidae: Heliconiinae: Acraeini): sequence, gene organization and a unique tRNA translocation eventJing Hu
College of Life Sciences, Anhui Normal University, Wuhu, 241000, China
Mol Biol Rep 37:3431-8. 2010In this paper, the complete mitochondrial genome of Acraea issoria (Lepidoptera: Nymphalidae: Heliconiinae: Acraeini) is reported; a circular molecule of 15,245 bp in size. For A...
- DNA barcodes distinguish species of tropical LepidopteraMehrdad Hajibabaei
Department of Integrative Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
Proc Natl Acad Sci U S A 103:968-71. 2006..Here we show that cytochrome c oxidase I DNA barcodes effectively discriminate among species in three Lepidoptera families from Area de Conservación Guanacaste in northwestern Costa Rica. We found that 97...
- The genome sequence and evolution of baculovirusesElisabeth A Herniou
Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
Annu Rev Entomol 48:211-34. 2003..Examination of gene order conservation revealed a core gene cluster of four genes, helicase, lef-5, ac96, and 38K(ac98), whose relative positions are conserved in all baculovirus genomes...
- Genomic outposts serve the phylogenomic pioneers: designing novel nuclear markers for genomic DNA extractions of lepidopteraNiklas Wahlberg
Department of Zoology, Stockholm University, Stockholm, Sweden
Syst Biol 57:231-42. 2008..We test this approach on Lepidoptera, searching the draft genomic sequence of the silk moth Bombyx mori, for exons > 500 bp in length, removing ..
- Biochemistry and genetics of insect resistance to Bacillus thuringiensisJuan Ferré
Department of Genetics, University of Valencia, 46110 Burjassot Valencia, Spain
Annu Rev Entomol 47:501-33. 2002..The understanding of the biochemical and genetic basis of resistance to Bt can help design appropriate management tactics to delay or reduce the evolution of resistance in insect populations...
- Barcoding lepidoptera: current situation and perspectives on the usefulness of a contentious techniqueKarina L Silva-Brandão
Depto de Entomologia e Acarologia, Escola Superior de Agricultura Luiz de Queiroz, Univ de São Paulo, Piracicaba, SP
Neotrop Entomol 38:441-51. 2009..For insects of the order Lepidoptera neither side seems totally correct or wrong, and although many groups of lepidopterans have been taxonomically ..
- Sex chromosomes and sex determination in LepidopteraW Traut
Universitat Lubeck, Zentrum fur Medizinische Strukturbiologie, Institut fur Biologie, Lubeck, Germany
Sex Dev 1:332-46. 2007The speciose insect order Lepidoptera (moths and butterflies) and their closest relatives, Trichoptera (caddis flies), share a female-heterogametic sex chromosome system...
- The complete nucleotide sequence of the mitochondrial genome of the cabbage butterfly, Artogeia melete (Lepidoptera: Pieridae)Guiyun Hong
Department of Biotechnology, Hefei University of Technology, Hefei 230009, China
Acta Biochim Biophys Sin (Shanghai) 41:446-55. 2009..The gene order of A. melete mitogenome is typical of Lepidoptera and differs from the insect ancestral type in the location of trnM. The A...
- Survey of a salivary effector in caterpillars: glucose oxidase variation and correlation with host rangeHerb Eichenseer
Pioneeer Hi Bred International Crop Genetics Research and Development, Johnston, IA 50131, USA
J Chem Ecol 36:885-97. 2010..In this study, we examined the labial gland GOX activities in 23 families of Lepidoptera (85 species) and two families of plant-feeding Hymenoptera (three species)...
- Transcriptomic profiling of Microplitis demolitor bracovirus reveals host, tissue and stage-specific patterns of activityKavita Bitra
Department of Entomology, University of Georgia, Athens, GA 30602, USA
J Gen Virol 92:2060-71. 2011..demolitor, albeit at much lower levels than in P. includens. However, another encapsidated gene (orph-B1) was expressed in adult M. demolitor at similar levels to those detected in P. includens...
- Development, survival and fitness performance of Helicoverpa zea (Lepidoptera: Noctuidae) in MON810 Bt field cornT A Horner
USDA, APHIS, PPQ, 4700 River Road, Unit 133, Riverdale, MD 20737, USA
J Econ Entomol 96:914-24. 2003..zea populations. Implications of localized population suppression are discussed...
- The differential effects of herbivory by first and fourth instars of Trichoplusia ni (Lepidoptera: Noctuidae) on photosynthesis in Arabidopsis thalianaJennie Y Tang
Department of Plant Biology, University of Illinois at Urbana Champaign, 265 Morrill Hall, 505 S Goodwin Ave, Urbana, IL 61801 3707, USA
J Exp Bot 57:527-36. 2006..The mode of feeding by different instars of T. ni determined the photosynthetic response to herbivory, which appeared to be mediated by the level of water stress associated with herbivore damage...
- Mitochondrial genome of the cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) and comparison with other LepidopteransJiao Yin
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, People s Republic of China
Mitochondrial DNA 21:160-9. 2010..The H. armigera A+T-rich region contains a conserved structure combining the motif ATAGA and a 19-bp poly-T stretch, but absence of the 9-bp poly-A element upstream of trnM...
- Physiological significance of alternatively spliced exon combinations of the single-copy gene class A chitin synthase in the insect Ostrinia furnacalis (Lepidoptera)M Qu
School of Bioscience and Biotechnology, Dalian University of Technology, Dalian, China
Insect Mol Biol 21:395-404. 2012..Spliced exons 2a and 2b have also been observed in Bombyx mori; therefore, this work provides new insights into the regulation of insect chitin synthase, particularly in lepidopteran insects...
- Towards a global barcode library for Lymantria (Lepidoptera: Lymantriinae) tussock moths of biosecurity concernJeremy R deWaard
Forest Sciences, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 5:e14280. 2010....
- Major putative pesticide receptors, detoxification enzymes, and transcriptional profile of the midgut of the tobacco budworm, Heliothis virescens (Lepidoptera: Noctuidae)Yu Cheng Zhu
USDA ARS JWDSRC, Stoneville, MS 38776, USA
J Invertebr Pathol 106:296-307. 2011..Future development resistance management strategies could benefit from this study and help continue research to identify key genes targetable by classic and novel approaches...
- Complete nucleotide sequence and organization of the mitogenome of the red-spotted apollo butterfly, Parnassius bremeri (Lepidoptera: Papilionidae) and comparison with other lepidopteran insectsMan Il Kim
College of Agriculture and Life Sciences, Chonnam National University, Gwangju 500 757, Korea
Mol Cells 28:347-63. 2009The 15,389-bp long complete mitogenome of the endangered red-spotted apollo butterfly, Parnassius bremeri (Lepidoptera: Papilionidae) was determined in this study...
- Simultaneous feeding by aboveground and belowground herbivores attenuates plant-mediated attraction of their respective natural enemiesSergio Rasmann
Evolutionary Entomology, Institute of Zoology, University of Neuchatel, Rue Emile Argand 11, CP 158, CH 2009 Neuchatel, Switzerland
Ecol Lett 10:926-36. 2007..This first study to measure effects of belowground herbivory on aboveground tritrophic signalling and vice-versa reemphasizes the important role of plants in bridging interactions between spatially distinct components of the ecosystem...
- Repetitive genome elements in a European corn borer, Ostrinia nubilalis, bacterial artificial chromosome library were indicated by bacterial artificial chromosome end sequencing and development of sequence tag site markers: implications for lepidopteran gBrad S Coates
USDA ARS, Corn Insects and Crop Genetics Research Unit, Genetics Laboratory, Iowa State University, Ames, IA 50011, USA
Genome 52:57-67. 2009..Single-locus sequence tag site markers described here have downstream application for integration within linkage maps and comparative genomic studies...
- The complete nucleotide sequence of the mitochondrial genome of Phthonandria atrilineata (Lepidoptera: Geometridae)Ling Yang
School of Life Sciences, University of Science and Technology of China, Hefei, 230027, People s Republic of China
Mol Biol Rep 36:1441-9. 2009..The phylogenetic relationships were reconstructed with the concatenated sequences of the 13 PCGs of the mitochondrial genome, which confirmed that P. atrilineata is most closely related to the superfamily Bombycoidea...
- A helitron-like transposon superfamily from lepidoptera disrupts (GAAA)(n) microsatellites and is responsible for flanking sequence similarity within a microsatellite familyBrad S Coates
USDA ARS, Iowa State University, Ames, 50011, USA
J Mol Evol 70:275-88. 2010..Transposition of MINE-1 members in Lepidoptera has resulted in the disruption of (GAAA)(n) microsatellite loci, has impacted the application of microsatellite-..
- Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strainGeorge Aperis
Division of Infectious Diseases, Massachusetts General Hospital, Gray Jackson 504, 55 Fruit Street, Boston, MA 02114, USA
Microbes Infect 9:729-34. 2007We used the killing of Galleria mellonella (Lepidoptera: Pyralidae; the greater wax moth) caterpillar by the live vaccine strain (LVS) of Francisella tularensis to develop an invertebrate host system that can be used to study F...
- Evidence that the caterpillar salivary enzyme glucose oxidase provides herbivore offense in solanaceous plantsRichard O Musser
Department of Biological Sciences, Western Illinois University, Macomb, Illinois, USA
Arch Insect Biochem Physiol 58:128-37. 2005..Glucose oxidase is the first insect salivary enzyme shown to suppress wound-inducible herbivore defenses of plants...
- Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a unique family of invertebrate CD36-like proteinsM E Rogers
Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
J Neurobiol 49:47-61. 2001..The SNMPs are the only identified neuronal members of the CD36 family, and as such expand the activities of this gene family into roles influencing brain function and behavioral action...
- Mapping the larval midgut lumen proteome of Helicoverpa armigera, a generalist herbivorous insectYannick Pauchet
Department of Entomology and Mass Spectrometry Research Group, Max Planck Institute for Chemical Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
J Proteome Res 7:1629-39. 2008..Identification of the set of proteins that are secreted into the lumen will enable us to further characterize the nutritional and defensive functions of this important intraorganismal space...
- Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypolYing Bo Mao
National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, P R China
Nat Biotechnol 25:1307-13. 2007....
- Sequestration of defensive substances from plants by LepidopteraRitsuo Nishida
Laboratory of Chemical Ecology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
Annu Rev Entomol 47:57-92. 2002..This review illustrates the biochemical, physiological, and ecological characteristics of phytochemical-based defense systems that can shed light on the evolution of the widely developed sequestering lifestyles among the Lepidoptera.
- A gene-based linkage map for Bicyclus anynana butterflies allows for a comprehensive analysis of synteny with the lepidopteran reference genomePatricia Beldade
Institute of Biology, Leiden University, Leiden, The Netherlands
PLoS Genet 5:e1000366. 2009..This is discussed in relation to the identification of the loci contributing to color pattern evolution in butterflies...
- Biological identifications through DNA barcodesPaul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Proc Biol Sci 270:313-21. 2003..Its assembly will also generate important new insights into the diversification of life and the rules of molecular evolution...
- Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestionElaine Fitches
Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
J Insect Physiol 50:61-71. 2004..SFI1/GNA and similar fusion proteins offer a novel and effective approach for delivering haemolymph active toxins by oral administration, which could be used in crop protection by expression in transgenic plants...
- Assessing the value of DNA barcodes for molecular phylogenetics: effect of increased taxon sampling in lepidopteraJohn James Wilson
Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 6:e24769. 2011..Here I test this hypothesis using a large dataset of macrolepidopteran DNA barcodes...
- Purification and characterization of an N-acetylglucosamine-binding lectin from Koelreuteria paniculata seeds and its effect on the larval development of Callosobruchus maculatus (Coleoptera: Bruchidae) and Anagasta kuehniella (Lepidoptera: Pyralidae)Maria Ligia Rodrigues Macedo
Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Ciencias Naturais, Universidade Federal de Mato Grosso do Sul UFMS, Avenida Olinto Mancini 1662, Colinos, CP 210, CEP 79603 011 Três Lagoas, MS, Brazil
J Agric Food Chem 51:2980-6. 2003..65% KpLec produced an LD(50), whereas 0.2% KpLec produced an ED(50). The transformation of genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops...
- Insecticide resistance in populations of the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), from the state of Pernambuco, BrazilV C Santos
Depto de Agronomia Entomologia, Univ Federal Rural de Pernambuco, Recife, PE, Brasil
Neotrop Entomol 40:264-70. 2011..These results indicated that control failures were associated with resistance by some of the evaluated insecticides, reinforcing the need for resistance management in areas of the state of Pernambuco...
- Population genetics of ecological communities with DNA barcodes: an example from New Guinea LepidopteraKathleen J Craft
Department of Plant Biology, University of Minnesota, Saint Paul, MN 55108, USA
Proc Natl Acad Sci U S A 107:5041-6. 2010..Contradictory estimates of host specificity and beta diversity in tropical Lepidoptera (moths and butterflies) from New Guinea and the Americas have sparked debate on the role of host-associated ..
- Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera)Sven Sehlmeyer
Institute for Pharmaceutical Biology, TU Braunschweig, Braunschweig, Germany
PLoS ONE 5:e10435. 2010..However, the previously identified senecionine N-oxygenase of the arctiid moth Tyria jacobaeae (Lepidoptera) indicates that FMOs have been recruited during the adaptation of this insect to plants that accumulate toxic ..
- Reduced levels of membrane-bound alkaline phosphatase are common to lepidopteran strains resistant to Cry toxins from Bacillus thuringiensisJuan Luis Jurat-Fuentes
Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, Tennessee, United States of America
PLoS ONE 6:e17606. 2011....
- Coevolution between pathogen-derived proteinases and proteinase inhibitors of host insectsAndreas Vilcinskas
Justus Liebig University of Giessen, Institute of Phytopathology and Applied Zoology at the Interdisciplinary Research Center, Giessen, Germany
Virulence 1:206-14. 2010....
- Baculovirus per os infectivity factors form a complex on the surface of occlusion-derived virusKe Peng
Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
J Virol 84:9497-504. 2010..We propose that PIF1, PIF2, PIF3, and P74 form an evolutionarily conserved complex on the ODV surface, which has an essential function in the initial stages of baculovirus oral infection...
- Physiology and glomerular projections of olfactory receptor neurons on the antenna of female Heliothis virescens (Lepidoptera: Noctuidae) responsive to behaviorally relevant odorsN K Hillier
Department of Biology, University of Utah, Room 201 South Biology, Salt Lake City, UT 84112, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:199-219. 2006..Noctuidae: Lepidoptera) were investigated using a combination of cut-sensillum recording and cobalt-lysine staining techniques...
- Salivary glucose oxidase from caterpillars mediates the induction of rapid and delayed-induced defenses in the tomato plantDonglan Tian
Department of Entomology, Center for Chemical Ecology, Penn State University, University Park, Pennsylvania, USA
PLoS ONE 7:e36168. 2012..Examination of saliva from other caterpillar species indicates that saliva from the noctuids Spodoptera exigua and Heliothis virescens also induced Pin2 transcripts...
- Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from ChinaHaonan Zhang
Key Laboratory of Integrated Management of Crop Diseases and Pests Ministry of Education, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Proc Natl Acad Sci U S A 109:10275-80. 2012..The results suggest that resistance management strategies must account for diverse resistance alleles in field-selected populations, including nonrecessive alleles...
- Laboratory and field evaluations of transgenic soybean exhibiting high-dose expression of a synthetic Bacillus thuringiensis cry1A gene for control of LepidopteraTed C MacRae
Monsanto Company, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
J Econ Entomol 98:577-87. 2005..These results demonstrate that expression of TIC107 in soybean can not only achieve highly efficacious control of several lepidopterans under field conditions but also provide a high dose for effective insect resistance management...
- Characterization of the complete mitochondrial genomes of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae)Huan Na Chai
Institute of Applied Entomology, Yangzhou University, Yangzhou 225009, China
Int J Biol Sci 8:561-79. 2012The complete mitochondrial genomes (mitogenomes) of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae) were determined and analyzed. The circular genomes were 15,388 bp long for C. medinalis and 15,395 bp long for C...
- Adenanthera pavonina trypsin inhibitor retard growth of Anagasta kuehniella (Lepidoptera: Pyralidae)Maria Ligia Rodrigues Macedo
Laboratório de Purificação de Proteínas e suas Funções Biológicas, Depto De Tecnologia de Alimentos e Saúde Pública, CCBS, Universidade Federal de Mato Grosso do Sul, CP 549, CEP 79070 900, Brazil
Arch Insect Biochem Physiol 73:213-31. 2010..In addition, the tryptic activity in ApTI -fed larvae was sensitive to ApTI. These results suggest that ApTI have a potential antimetabolic effect when ingested by A. kuehniella...
- Large-scale evolutionary patterns of host plant associations in the LepidopteraSteph B J Menken
Institute for Biodiversity and Ecosystem Dynamics, Section Evolutionary Biology, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands
Evolution 64:1098-119. 2010We characterized evolutionary patterns of host plant use across about 2500 species of British Lepidoptera, using character optimization and independent phylogenetic contrasts among 95 operational taxa, and evaluated the extent to which ..
- Molecular phylogeny of the small ermine moth genus Yponomeuta (Lepidoptera, Yponomeutidae) in the palaearcticHubert Turner
Evolutionary Biology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 5:e9933. 2010The small ermine moth genus Yponomeuta (Lepidoptera, Yponomeutidae) contains 76 species that are specialist feeders on hosts from Celastraceae, Rosaceae, Salicaceae, and several other plant families...
- A comprehensive characterization of the caspase gene family in insects from the order LepidopteraJuliette Courtiade
Department of Entomology, Max Planck Institute for Chemical Ecology, Jena, Germany
BMC Genomics 12:357. 2011..In Lepidoptera, apoptosis is crucial in processes such as metamorphosis or defending against baculovirus infection...
- Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo suppressalis (Lepidoptera: Pyralidae)Xiaojing Jiang
Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing Agricultural University, Weigang No 1, Nanjing 210095, China
Biochem Biophys Res Commun 378:269-72. 2009..The assay offers a prospect for rapid monitoring of resistance and assisting with the appropriate choice of insecticide for combating damage caused by C. suppressalis...
- PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cellsAndrea J Pruijssers
Department of Entomology and Center for Emerging and Tropical Diseases, University of Georgia, Athens, Georgia 30602, USA
J Virol 81:1209-19. 2007..PTP-H2 and -H3 localized to focal adhesions in S2 cells, and coexpression with another MdBV gene product, Glc1.8, resulted in complete inhibition of phagocytosis...
- Jasmonate in lepidopteran eggs and neonatesJohn F Tooker
Department of Entomology, The Pennsylvania State University, University Park, PA 16802, USA
J Chem Ecol 31:2753-9. 2005..of all nine lepidopteran species that we screened, representing four superfamilies and five families of Lepidoptera. Concentrations of JA in some lepidopteran species far exceeded those found in most plant species...
- Expressed sequence tags from larval gut of the European corn borer (Ostrinia nubilalis): exploring candidate genes potentially involved in Bacillus thuringiensis toxicity and resistanceChitvan Khajuria
Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506, USA
BMC Genomics 10:286. 2009b>Lepidoptera represents more than 160,000 insect species which include some of the most devastating pests of crops, forests, and stored products. However, the genomic information on lepidopteran insects is very limited...
- Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollwormShai Morin
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:5004-9. 2003..Together with previous evidence, the results reported here identify the cadherin gene as a leading target for DNA-based screening of resistance to Bt crops in lepidopteran pests...
- Mitochondrial and microsatellite DNA markers reveal a Balkan origin for the highly invasive horse-chestnut leaf miner Cameraria ohridella (Lepidoptera, Gracillariidae)R Valade
INRA, UR0633 Zoologie Forestière, Orleans, France
Mol Ecol 18:3458-70. 2009..ohridella sampled in natural stands of horse-chestnuts in the southern Balkans. These findings suggest that European populations of C. ohridella may indeed derive from the southern Balkans...
- Immunity or digestion: glucanase activity in a glucan-binding protein family from LepidopteraYannick Pauchet
Department of Entomology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoell Str 8, 07745 Jena, Germany
J Biol Chem 284:2214-24. 2009..Homologs of this predominantly midgut-expressed gene from many Lepidoptera possess key residues shown to be part of the active site of other glucanases, and form a cluster that is ..
- Identification of novel Bacillus thuringiensis Cry1Ac binding proteins in Manduca sexta midgut through proteomic analysisRebecca J McNall
Department of Biochemistry and Molecular Biology, University of Georgia, 413 Biological Sciences Building, 120 Cedar Street, Athens, GA 30602, USA
Insect Biochem Mol Biol 33:999-1010. 2003..Results generally did not produce matches to M. sexta proteins, but did match proteins of other Lepidoptera. Actin and alkaline phosphatase were identified as novel proteins that bind Cry1Ac in addition to the ..
- Developmental and hormonal regulation of midgut remodeling in a lepidopteran insect, Heliothis virescensR Parthasarathy
Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
Mech Dev 124:23-34. 2007Midgut tissue undergoes remodeling during metamorphosis in insects belonging to orders Lepidoptera and Diptera...
- Relative fitness of Cry1A-resistant and -susceptible Helicoverpa armigera (Lepidoptera: Noctuidae) on conventional and transgenic cottonLisa J Bird
CSIRO Entomology, GPO Box 1700, Canberra ACT 2601, Australia
J Econ Entomol 97:1699-709. 2004..There was a significant reduction in the survival of postdiapausal adults from the resistant strain and the F1 strains, indicating that there is a nonrecessive overwintering cost associated with Cry1A resistance in H. armigera...
- Jasmonate and salicylate induce expression of herbivore cytochrome P450 genesXianchun Li
Department of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Nature 419:712-5. 2002..This ability to 'eavesdrop' on plant defence signals protects H. zea against toxins produced by host plants...
- Effect of pre-incubation temperature on susceptibility of Galleria mellonella larvae to infection by Candida albicansPeter Mowlds
Medical Mycology Unit, NICB, Department of Biology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
Mycopathologia 165:5-12. 2008..These results indicate that exposure of larvae to mild thermal shock conditions induces a protective cellular and humoral immune response mediated by increased numbers of haemocytes and elevated expression of antimicrobial peptides...
- DNA-based detection of Bt resistance alleles in pink bollwormShai Morin
Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Insect Biochem Mol Biol 34:1225-33. 2004..The results suggest that the DNA-based detection method described here could greatly increase the efficiency of monitoring for resistance to Cry1Ac compared to bioassays that detect rare individuals with homozygous resistance...
- Genome sequence and organization of a nucleopolyhedrovirus that infects the tea looper caterpillar, Ectropis obliquaXiu Cui Ma
Institute of Insect Science, Zhejiang University, 268 Kaixuan Road, Hangzhou, 310029, China
Virology 360:235-46. 2007..Gene parity plot analysis and percent identity of gene homologues suggested that EcobNPV is a Group II NPV, although its genomic organization was highly distinct...
- Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXRFrançois Bonneton
UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
Mol Biol Evol 20:541-53. 2003..structural comparisons reveal high divergence rates, for both ECR and USP-RXR, specifically among Diptera and Lepidoptera. The most impressive differences affect the ligand-binding domain of USP-RXR...
- Population genetic structure of Chilo suppressalis (Walker) (Lepidoptera: Crambidae): strong subdivision in China inferred from microsatellite markers and mtDNA gene sequencesXiang Feng Meng
State Key Laboratory of Rice Biology, Institute of Insect Sciences, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China
Mol Ecol 17:2880-97. 2008..g. the last glacial maximum) and subsequently strengthened by the domestication of rice...
- Comparative study on characteristics of lysozymes from the hemolymph of three lepidopteran larvae, Galleria mellonella, Bombyx mori, Agrius convolvuliKyung Hyun Yu
Department of Life Science, Hoseo University, 29 1 Sechuli, Baebang myun, Asan City Choongnam Do 336 795, South Korea
Dev Comp Immunol 26:707-13. 2002..Taken together, we conclude three Lepidopteran lysozymes have a common distinct structure and have an antibacterial activity, which is absent in chicken lysozyme, against Gram-negative bacteria...
- Effects of cotton cultivar on fitness costs associated with resistance of pink bollworm (Lepidoptera: Gelechiidae) to Bt cottonYves Carriere
Department of Entomology, 410 Forbes Building, Tucson, AZ 85721, USA
J Econ Entomol 98:947-54. 2005..Thus, knowledge of the interaction between host plants and fitness costs associated with resistance to Bt crops could be helpful in guiding the choice of refuge cultivars...
- Insecticidal action of Bauhinia monandra leaf lectin (BmoLL) against Anagasta kuehniella (Lepidoptera: Pyralidae), Zabrotes subfasciatus and Callosobruchus maculatus (Coleoptera: Bruchidae)Maria Ligia Rodrigues Macedo
Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Ciencias Naturais, CPTL, Universidade Federal do Mato Grosso do Sul UFMS, Avenida Capitão Olinto Mancini, Tres Lagoas, MS, Brazil
Comp Biochem Physiol A Mol Integr Physiol 146:486-98. 2007..maculatus larvae increased the digestion of potato starch by 25% compared with the control. The transformation of the genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops...
- The evolution of female flightlessness among Ennominae of the Holarctic forest zone (Lepidoptera, Geometridae)Niklas Wahlberg
Laboratory of Genetics, Department of Biology, University of Turku, FIN 20014 Turku, Finland
Mol Phylogenet Evol 55:929-38. 2010..to facilitate the study of the evolution of female flightlessness among the geometrid subfamily Ennominae (Lepidoptera, Geometridae), we carried out a phylogenetic analysis based on a morphological data matrix, and DNA sequences...
- Comprehensive gene and taxon coverage elucidates radiation patterns in moths and butterfliesMarko Mutanen
Zoological Museum, Department of Biology, University of Oulu, PO Box 3000, Oulu 90014, Finland
Proc Biol Sci 277:2839-48. 2010b>Lepidoptera (butterflies and moths) represent one of the most diverse animals groups. Yet, the phylogeny of advanced ditrysian Lepidoptera, accounting for about 99 per cent of lepidopteran species, has remained largely unresolved...
- Selection and heritability of resistance to Bacillus thuringiensis subsp kurstaki and transgenic cotton in Helicoverpa armigera (Lepidoptera: Noctuidae)Mei guang Lu
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China
Pest Manag Sci 60:887-93. 2004....
- Assessing the value of DNA barcodes and other priority gene regions for molecular phylogenetics of LepidopteraJohn James Wilson
Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 5:e10525. 2010Despite apparently abundant amounts of observable variation and species diversity, the order Lepidoptera exhibits a morphological homogeneity that has provided only a limited number of taxonomic characters and led to widespread use of ..
- Susceptibility of dipel-resistant and -susceptible Ostrinia nubilalis (Lepidoptera: Crambidae) to individual Bacillus thuringiensis protoxinsHuarong Li
Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
J Econ Entomol 98:1333-40. 2005..054 and 0.162 microg/ml. However, growth inhibition with Cry2Aa was not significant at either dose. These data provide information on the spectrum of resistance and cross-resistance to individual Cry protoxins in this strain...
- Feeding mechanisms of adult Lepidoptera: structure, function, and evolution of the mouthpartsHarald W Krenn
Department of Evolutionary Biology, University of Vienna, Vienna, Austria
Annu Rev Entomol 55:307-27. 2010The form and function of the mouthparts in adult Lepidoptera and their feeding behavior are reviewed from evolutionary and ecological points of view...
- Comparative susceptibility of European corn borer, southwestern corn borer, and sugarcane borer (Lepidoptera: Crambidae) to Cry1Ab protein in a commercial Bacillus thuringiensis corn hybridFangneng Huang
Department of Entomology, Louisiana State University AgCenter, Baton Rouge, LA 70803, USA
J Econ Entomol 99:194-202. 2006..saccharalis. The lower susceptibility of D. saccharalis to Cry1Ab protein suggests that it is necessary to verify if a high-dose Bt corn for O. nubilalis and D. grandiosella is also a high dose for D. saccharalis...
- Differential introgression causes genealogical discordance in host races of Acrocercops transecta (Insecta: Lepidoptera)Issei Ohshima
Systematic Entomology, Department of Ecology and Systematics, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
Mol Ecol 19:2106-19. 2010..Thus, the results show that a low level of gene flow coupled with the inflexible female host preference differentiates histories of divergence between maternally and biparentally inherited genes in this host race system...
- Interaction of the bacteria Xenorhabdus nematophila (Enterobactericeae) and Bacillus subtilis (Bacillaceae) with the hemocytes of larval Malacosoma disstria (Insecta: Lepidoptera: Lasiocampidae)Paschalis Giannoulis
Department of Natural Resource Sciences, Macdonald Campus of McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Que, Canada H9X 3V9
J Invertebr Pathol 94:20-30. 2007..nematophila emerged into the hemolymph. Apolipophorin-III-like protein once bound to the bacteria slowed their removal from the hemolymph...
- [Molecular and morphological differentiation of Oleria makrena (Hewitson) and Oleria fumata (Haensch) (Lepidoptera: Ithomiinae)]Luz M Gómez-P
Grupo Sistemática Molecular, Univ Nacional de Colombia, Antioquia, Colombia
Neotrop Entomol 38:616-23. 2009..The analysis of 579 base pairs (bp) indicated 46 nucleotide differences between both species...
- Anopheles gambiae alkaline phosphatase is a functional receptor of Bacillus thuringiensis jegathesan Cry11Ba toxinGang Hua
Department of Entomology, University of Georgia, Athens, Georgia 30602 2603, USA
Biochemistry 48:9785-93. 2009..In bioassays against An. gambiae larvae, the presence of AgALP1(t) reduced larval mortality from 78 to 8%. We conclude that AgALP1 is a binding protein and a functional receptor for Cry11Ba toxin...
- Venom of Pteromalus puparum (Hymenoptera: Pteromalidae) induced endocrine changes in the hemolymph of its host, Pieris rapae (Lepidoptera: Pieridae)Jia Ying Zhu
State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Arch Insect Biochem Physiol 71:45-53. 2009..The results demonstrate that venom alone of this parasitoid wasp can disrupt its host's endocrine system...
- Mannose-binding lectin from yam (Dioscorea batatas) tubers with insecticidal properties against Helicoverpa armigera (Lepidoptera: Noctuidae)Yuki Ohizumi
Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 981 8555, Japan
J Agric Food Chem 57:2896-902. 2009..DB1 was examined for insecticidal activity against Helicoverpa armigera (Lepidoptera: Noctuidae) larvae at different stages of development...
- Assessing diversity of diurnal lepidoptera in habitat fragments: testing the efficiency of strip transectsMatthew R Williams
Centre for Ecosystem Diversity and Dynamics, Department of Environmental Biology, Curtin University, PO Box U1987, Perth, Western Australia 6845, Australia
Environ Entomol 37:1313-22. 2008..The abundance of diurnal lepidoptera showed large temporal variation over the flight season and varied to a lesser extent with time of day and ..
- Common genomic structure for the Lepidoptera cadherin-like genesYolanda Bel
Genetics Department, University of Valencia, Dr Moliner, 50, 46100, Burjassot, Valencia, Spain
Gene 381:71-80. 2006A cadherin-like protein present in the midgut epithelial cells of Lepidoptera is associated with insect resistance to Bacillus thuringiensis Cry toxins...
- Identification, cloning and expression of a Cry1Ab cadherin receptor from European corn borer, Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae)Ronald D Flannagan
Pioneer Hi Bred International Inc, 7301 NW 62nd Avenue, P O Box 85, Johnston, IA 50131 0085, USA
Insect Biochem Mol Biol 35:33-40. 2005..1 microg/ml. These results in combination suggest strongly that a cadherin-like protein acts as receptor and is involved with Cry1Ab toxicity in O. nubilalis...
- The evolutionary origin of signa in female Lepidoptera: natural and sexual selection hypothesesCarlos Cordero
Departamento de Ecologia Evolutiva, Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Apdo Post 70 275, Coyoacan 04510, DF, Mexico
J Theor Biol 232:443-9. 2005..wall of the female corpus bursae (structure where males deposit a spermatophore during copulation) of many Lepidoptera that assist in tearing open spermatophores...
- Long-term selection for resistance to transgenic cotton expressing Bacillus thuringiensis toxin in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)Fengxia Meng
Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, China National Centre for Monitoring Pesticide Resistance, Department of Pesticide Science, Nanjing Agricultural University, Nanjing 210095, China
Pest Manag Sci 60:167-72. 2004..The results indicated that it is very important to develop and implement effective resistance-management strategies and to detect early resistance to Bt cotton in field populations...
- Relationship between maize stem structural characteristics and resistance to pink stem borer (Lepidoptera: Noctuidae) attackR Santiago
E U E T Forestal, Universidad de Vigo, Campus Universitario Pontevedra, E 36005, Pontevedra, Spain
J Econ Entomol 96:1563-70. 2003..Among the traits considered, the LMA was the most promising as an indicator of resistance to pink stem borer, although further experimentation is necessary...
- Structure-based analysis of the ultraspiracle protein and docking studies of putative ligandsSouphatta Sasorith
Département de Génomique et de Biologie Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, France
J Insect Sci 2:25. 2002..The interaction between the ligand and the receptor are examined in terms of the pocket shape as well as in terms of the chemical nature of the residues lining the ligand binding cavity...
- Inheritance of resistance to Bacillus thuringiensis Cry1Ac toxin in a greenhouse-derived strain of cabbage looper (Lepidoptera: Noctuidae)Wendy C Kain
Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
J Econ Entomol 97:2073-8. 2004..Therefore, we conclude that the inheritance of the resistance to Cry1Ac in the T. ni larvae is monogenic...
Research Grants110 found, 100 shown here
- Functional Domains of Bacillus thuringiensis EndotoxinsDONALD DEAN; Fiscal Year: 2007..these toxins bind to specific receptors on the mosquito midgut as recognized in model insect-toxin studies (the Lepidoptera-toxin paradigm); i.e...
- FUNCTION OF THE BACULOVIRUS MEMBRANE FUSION PROTEINGARY BLISSARD; Fiscal Year: 2003..abstract_text> ..
- Baculovirus envelope proteins and insect cellsGARY BLISSARD; Fiscal Year: 2007..In addition, results of many of these studies will be directly applicable to new and exciting biotechnological applications of baculoviruses in mammalian cells. ..
- PROTEINASE SYSTEMS IN INSECT HEMOLYMPHMichael Kanost; Fiscal Year: 2003..4. Analyze the regulation of plasma proteinases by M. sexta serine protease inhibitors (serpins). ..
- Apoptosis as an anti-viral response in mosquito midgutROLLIE CLEM; Fiscal Year: 2007....
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2007....
- Molecular Improvement of Bacterial Mosquito LarvicidesBrian A Federici; Fiscal Year: 2010..This is unlikely to be true for any of the other molecular technologies for vector control and disease reduction under development. ..
- INTERACTIONS BETWEEN PATHOGENS AND ARTHROPOD MIDGUT EPITHELIAL CELLSROLLIE CLEM; Fiscal Year: 2002..The proposed project thus addresses two key aspects of pathogen-arthropod host interactions that are fundamental to the pathogen survival and transmission. ..
- Genetics and evolution of gene copy number polymorphismErik Dopman; Fiscal Year: 2007..These long-term objectives have been formulated to test specific predictions for genes with variable copies. ..
- High-throughput Screens for P. falciparum Malaria (RMI)Jon Clardy; Fiscal Year: 2004..Multi-component screens, based on the GFP-assay, will also be developed, identifying chemotypes that reverse drug resistance to previously effective agents. ..
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald Jarvis; Fiscal Year: 2009....
- Structural and Functional Studies on ProteinsJon Clardy; Fiscal Year: 2007..This scan, if successful, would provide functional annotation for the endogenous function of previously characterized small molecules. Finally, some polypeptides with antibiotic activity will be investigated. ..
- Molecule-to-gene approaches to new natural productsJon Clardy; Fiscal Year: 2009..This project describes two approaches, which minimize some of the liabilities of traditional natural products discovery techniques that could lead to an important small molecule stream for HTS. ..
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED A contact NOOR; Fiscal Year: 2010....
- STRUCTURAL STUDIES ON BIOACTIVE NATURAL PRODUCTSJon Clardy; Fiscal Year: 1993..The molecular structure information obtained from this research will be of direct benefit to chemistry, biochemistry and pharmacology. Several of the research targets could become useful drugs for the treatment of human diseases...
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald L Jarvis; Fiscal Year: 2010....
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald Jarvis; Fiscal Year: 2001..This could lead to more effective ways to control medically and agriculturally significant insects and/or the diseases they help to spread, which would have a major impact on worldwide public health. ..
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2001....
- STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXESJon Clardy; Fiscal Year: 1993..The structures of the complexes would be important for basic science and would provide much needed information on the pathway of cytoplasmic signal transduction...
- Mapping Adeno-associated Virus Capsid Structural and Dynamic TransitionsBrian P Bothner; Fiscal Year: 2010..The availability of this information will be valuable for the development of next generation recombinant vectors with improved efficacy. This project aims to fill this dearth in our knowledge base of basic AAV biology. ..
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2009....
- Molecule-to-gene approaches to new natural productsJon Clardy; Fiscal Year: 2010..This project describes two approaches, which minimize some of the liabilities of traditional natural products discovery techniques that could lead to an important small molecule stream for HTS. ..
- Genetics of speciation in Drosophila pseudoobscuraMOHAMED A NOOR; Fiscal Year: 2010..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- Highly Improved Bacterial Larvicides for Vector ControlBrian Federici; Fiscal Year: 2007..This collaboration has the common goal of having new products based on these recombinant bacteria on the market within five years, sooner if possible. ..
- Target-Based High-Throughput Screens for Plasmodium falciparum MalariaJon Clardy; Fiscal Year: 2007..Here we will develop a new target-based assay to screen structurally diverse small molecule libraries to identify new antimalarial agents to kill the parasite. ..
- STRUCTURAL STUDIES OF BIOACTIVE NATURAL PRODUCTSJon Clardy; Fiscal Year: 1980..Activity in an anticancer screen is the most important criterion but other activities such as antibiotic or CNS are also considered. ..
- STRUCTURAL STUDIES OF IMMUNOPHILINS AND RELATED PROTEINSJon Clardy; Fiscal Year: 2003..Structures such as fyn SH2-pYEEI/FK506-FKBP52 that illustrate the concept of using borrowed endogenous proteins to moderate the binding of hybrid small molecules. ..
- STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXESJon Clardy; Fiscal Year: 1999..Structures of both FKBP12-FK506 and cyclophilin A-Cyclphilin A complexes will be studied to design two distinctly different families of dimerizing agents with no affinity for wild type immunophilins. ..
- Genetics of mate discrimination in Drosophila pseudoobscuraMOHAMED NOOR; Fiscal Year: 2007..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- Molecular mechanisms of X. nematophila-nematode interactionHeidi Goodrich Blair; Fiscal Year: 2007..nematophila during colonization, further define a colonization-specific regulon, and expand our knowledge of the role of a ubiquitous transcription factor in the natural ecology of a bacterium. ..
- INTERACTION BETWEEN X NEMATOPHILUS AND ITS HOSTSHeidi Goodrich Blair; Fiscal Year: 2003..This work will provide insight into the genes and gene products that are essential for symbiosis and will aid in the elucidation of the regulation of host interactions in X. nematophilus and other bacteria. ..
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED NOOR; Fiscal Year: 2009....
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2005..Approaches to accessing and screening these natural products by heterologously expressing DNA obtained directly from the environment, eDNA, will be developed. ..