Genomes and Genes
Summary: A large order of insects comprising the butterflies and moths.
Publications258 found, 100 shown here
- RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental designOlle Terenius
Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden
J Insect Physiol 57:231-45. 2011..However, in Lepidoptera (moths and butterflies) RNAi has many times proven to be difficult to achieve...
- Toward reconstructing the evolution of advanced moths and butterflies (Lepidoptera: Ditrysia): an initial molecular studyJerome C Regier
Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
BMC Evol Biol 9:280. 2009In the mega-diverse insect order Lepidoptera (butterflies and moths; 165,000 described species), deeper relationships are little understood within the clade Ditrysia, to which 98% of the species belong...
- Genomic outposts serve the phylogenomic pioneers: designing novel nuclear markers for genomic DNA extractions of lepidopteraNiklas Wahlberg
Department of Zoology, Stockholm University, Stockholm, Sweden
Syst Biol 57:231-42. 2008..We test this approach on Lepidoptera, searching the draft genomic sequence of the silk moth Bombyx mori, for exons > 500 bp in length, removing ..
- Repetitive genome elements in a European corn borer, Ostrinia nubilalis, bacterial artificial chromosome library were indicated by bacterial artificial chromosome end sequencing and development of sequence tag site markers: implications for lepidopteran gBrad S Coates
USDA ARS, Corn Insects and Crop Genetics Research Unit, Genetics Laboratory, Iowa State University, Ames, IA 50011, USA
Genome 52:57-67. 2009..Single-locus sequence tag site markers described here have downstream application for integration within linkage maps and comparative genomic studies...
- Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypolYing Bo Mao
National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, P R China
Nat Biotechnol 25:1307-13. 2007....
- A gene-based linkage map for Bicyclus anynana butterflies allows for a comprehensive analysis of synteny with the lepidopteran reference genomePatricia Beldade
Institute of Biology, Leiden University, Leiden, The Netherlands
PLoS Genet 5:e1000366. 2009..This is discussed in relation to the identification of the loci contributing to color pattern evolution in butterflies...
- Biological identifications through DNA barcodesPaul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Proc Biol Sci 270:313-21. 2003..Its assembly will also generate important new insights into the diversification of life and the rules of molecular evolution...
- The complete nucleotide sequence of the mitochondrial genome of the cabbage butterfly, Artogeia melete (Lepidoptera: Pieridae)Guiyun Hong
Department of Biotechnology, Hefei University of Technology, Hefei 230009, China
Acta Biochim Biophys Sin (Shanghai) 41:446-55. 2009..The gene order of A. melete mitogenome is typical of Lepidoptera and differs from the insect ancestral type in the location of trnM. The A...
- Developmental and hormonal regulation of midgut remodeling in a lepidopteran insect, Heliothis virescensR Parthasarathy
Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
Mech Dev 124:23-34. 2007Midgut tissue undergoes remodeling during metamorphosis in insects belonging to orders Lepidoptera and Diptera...
- Mitochondrial and microsatellite DNA markers reveal a Balkan origin for the highly invasive horse-chestnut leaf miner Cameraria ohridella (Lepidoptera, Gracillariidae)R Valade
INRA, UR0633 Zoologie Forestière, Orleans, France
Mol Ecol 18:3458-70. 2009..ohridella sampled in natural stands of horse-chestnuts in the southern Balkans. These findings suggest that European populations of C. ohridella may indeed derive from the southern Balkans...
- A helitron-like transposon superfamily from lepidoptera disrupts (GAAA)(n) microsatellites and is responsible for flanking sequence similarity within a microsatellite familyBrad S Coates
USDA ARS, Iowa State University, Ames, 50011, USA
J Mol Evol 70:275-88. 2010..Transposition of MINE-1 members in Lepidoptera has resulted in the disruption of (GAAA)(n) microsatellite loci, has impacted the application of microsatellite-..
- Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollwormShai Morin
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:5004-9. 2003..Together with previous evidence, the results reported here identify the cadherin gene as a leading target for DNA-based screening of resistance to Bt crops in lepidopteran pests...
- Immunity or digestion: glucanase activity in a glucan-binding protein family from LepidopteraYannick Pauchet
Department of Entomology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoell Str 8, 07745 Jena, Germany
J Biol Chem 284:2214-24. 2009..Homologs of this predominantly midgut-expressed gene from many Lepidoptera possess key residues shown to be part of the active site of other glucanases, and form a cluster that is ..
- Identification of novel Bacillus thuringiensis Cry1Ac binding proteins in Manduca sexta midgut through proteomic analysisRebecca J McNall
Department of Biochemistry and Molecular Biology, University of Georgia, 413 Biological Sciences Building, 120 Cedar Street, Athens, GA 30602, USA
Insect Biochem Mol Biol 33:999-1010. 2003..Results generally did not produce matches to M. sexta proteins, but did match proteins of other Lepidoptera. Actin and alkaline phosphatase were identified as novel proteins that bind Cry1Ac in addition to the ..
- Expressed sequence tags from larval gut of the European corn borer (Ostrinia nubilalis): exploring candidate genes potentially involved in Bacillus thuringiensis toxicity and resistanceChitvan Khajuria
Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506, USA
BMC Genomics 10:286. 2009b>Lepidoptera represents more than 160,000 insect species which include some of the most devastating pests of crops, forests, and stored products. However, the genomic information on lepidopteran insects is very limited...
- Effect of pre-incubation temperature on susceptibility of Galleria mellonella larvae to infection by Candida albicansPeter Mowlds
Medical Mycology Unit, NICB, Department of Biology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
Mycopathologia 165:5-12. 2008..These results indicate that exposure of larvae to mild thermal shock conditions induces a protective cellular and humoral immune response mediated by increased numbers of haemocytes and elevated expression of antimicrobial peptides...
- Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXRFrançois Bonneton
UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
Mol Biol Evol 20:541-53. 2003..structural comparisons reveal high divergence rates, for both ECR and USP-RXR, specifically among Diptera and Lepidoptera. The most impressive differences affect the ligand-binding domain of USP-RXR...
- The complete nucleotide sequence of the mitochondrial genome of Phthonandria atrilineata (Lepidoptera: Geometridae)Ling Yang
School of Life Sciences, University of Science and Technology of China, Hefei, 230027, People s Republic of China
Mol Biol Rep 36:1441-9. 2009..The phylogenetic relationships were reconstructed with the concatenated sequences of the 13 PCGs of the mitochondrial genome, which confirmed that P. atrilineata is most closely related to the superfamily Bombycoidea...
- Comparative study on characteristics of lysozymes from the hemolymph of three lepidopteran larvae, Galleria mellonella, Bombyx mori, Agrius convolvuliKyung Hyun Yu
Department of Life Science, Hoseo University, 29-1 Sechuli, Baebang-Myun, Asan City Choongnam-Do 336-795, South Korea
Dev Comp Immunol 26:707-13. 2002..Taken together, we conclude three Lepidopteran lysozymes have a common distinct structure and have an antibacterial activity, which is absent in chicken lysozyme, against Gram-negative bacteria...
- Genome sequence and organization of a nucleopolyhedrovirus that infects the tea looper caterpillar, Ectropis obliquaXiu Cui Ma
Institute of Insect Science, Zhejiang University, 268 Kaixuan Road, Hangzhou, 310029, China
Virology 360:235-46. 2007..Gene parity plot analysis and percent identity of gene homologues suggested that EcobNPV is a Group II NPV, although its genomic organization was highly distinct...
- Effects of cotton cultivar on fitness costs associated with resistance of pink bollworm (Lepidoptera: Gelechiidae) to Bt cottonYves Carriere
Department of Entomology, 410 Forbes Building, Tucson, AZ 85721, USA
J Econ Entomol 98:947-54. 2005..Thus, knowledge of the interaction between host plants and fitness costs associated with resistance to Bt crops could be helpful in guiding the choice of refuge cultivars...
- Population genetic structure of Chilo suppressalis (Walker) (Lepidoptera: Crambidae): strong subdivision in China inferred from microsatellite markers and mtDNA gene sequencesXiang Feng Meng
State Key Laboratory of Rice Biology, Institute of Insect Sciences, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China
Mol Ecol 17:2880-97. 2008..g. the last glacial maximum) and subsequently strengthened by the domestication of rice...
- DNA-based detection of Bt resistance alleles in pink bollwormShai Morin
Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Insect Biochem Mol Biol 34:1225-33. 2004..The results suggest that the DNA-based detection method described here could greatly increase the efficiency of monitoring for resistance to Cry1Ac compared to bioassays that detect rare individuals with homozygous resistance...
- Selection and heritability of resistance to Bacillus thuringiensis subsp kurstaki and transgenic cotton in Helicoverpa armigera (Lepidoptera: Noctuidae)Mei guang Lu
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China
Pest Manag Sci 60:887-93. 2004....
- Gelechioidea (Insecta: Lepidoptera) systematics: a reexamination using combined morphology and mitochondrial DNA dataSibyl Rae Bucheli
Department of Entomology, The Ohio State University, 1315 Kinnear Road, Columbus, OH 43212 1157, USA
Mol Phylogenet Evol 35:380-94. 2005Phylogenies of Gelechioidea (Insecta: Lepidoptera) historically have been in disagreement and definitions vary at the family and subfamily levels...
- Identification, cloning and expression of a Cry1Ab cadherin receptor from European corn borer, Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae)Ronald D Flannagan
Pioneer Hi-Bred International Inc, 7301 NW 62nd Avenue, P.O. Box 85, Johnston, IA 50131-0085, USA
Insect Biochem Mol Biol 35:33-40. 2005..1 microg/ml. These results in combination suggest strongly that a cadherin-like protein acts as receptor and is involved with Cry1Ab toxicity in O. nubilalis...
- Susceptibility of dipel-resistant and -susceptible Ostrinia nubilalis (Lepidoptera: Crambidae) to individual Bacillus thuringiensis protoxinsHuarong Li
Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
J Econ Entomol 98:1333-40. 2005..054 and 0.162 microg/ml. However, growth inhibition with Cry2Aa was not significant at either dose. These data provide information on the spectrum of resistance and cross-resistance to individual Cry protoxins in this strain...
- Rapid responses to high temperature and desiccation but not to low temperature in the freeze tolerant sub-Antarctic caterpillar Pringleophaga marioni (Lepidoptera, Tineidae)Brent J Sinclair
Spatial, Physiological and Conservation Ecology Group, Department of Zoology, University of Stellenbosch, Private Bag X1, Matieland 7002, South Africa
J Insect Physiol 49:45-52. 2003..9 degrees C were investigated in the freeze tolerant sub-Antarctic caterpillar Pringleophaga marioni (Lepidoptera: Tineidae), the first time RCH has been investigated in a freeze tolerant arthropod...
- Inheritance of resistance to Bacillus thuringiensis Cry1Ac toxin in a greenhouse-derived strain of cabbage looper (Lepidoptera: Noctuidae)Wendy C Kain
Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
J Econ Entomol 97:2073-8. 2004..Therefore, we conclude that the inheritance of the resistance to Cry1Ac in the T. ni larvae is monogenic...
- Relationship between maize stem structural characteristics and resistance to pink stem borer (Lepidoptera: Noctuidae) attackR Santiago
E U E T Forestal, Universidad de Vigo, Campus Universitario Pontevedra, E 36005, Pontevedra, Spain
J Econ Entomol 96:1563-70. 2003..Among the traits considered, the LMA was the most promising as an indicator of resistance to pink stem borer, although further experimentation is necessary...
- Comparative susceptibility of European corn borer, southwestern corn borer, and sugarcane borer (Lepidoptera: Crambidae) to Cry1Ab protein in a commercial Bacillus thuringiensis corn hybridFangneng Huang
Department of Entomology, Louisiana State University AgCenter, Baton Rouge, LA 70803, USA
J Econ Entomol 99:194-202. 2006..saccharalis. The lower susceptibility of D. saccharalis to Cry1Ab protein suggests that it is necessary to verify if a high-dose Bt corn for O. nubilalis and D. grandiosella is also a high dose for D. saccharalis...
- Interaction of the bacteria Xenorhabdus nematophila (Enterobactericeae) and Bacillus subtilis (Bacillaceae) with the hemocytes of larval Malacosoma disstria (Insecta: Lepidoptera: Lasiocampidae)Paschalis Giannoulis
Department of Natural Resource Sciences, Macdonald Campus of McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Que, Canada H9X 3V9
J Invertebr Pathol 94:20-30. 2007..nematophila emerged into the hemolymph. Apolipophorin-III-like protein once bound to the bacteria slowed their removal from the hemolymph...
- Long-term selection for resistance to transgenic cotton expressing Bacillus thuringiensis toxin in Helicoverpa armigera (HÃ¼bner) (Lepidoptera: Noctuidae)Fengxia Meng
Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, China National Centre for Monitoring Pesticide Resistance, Department of Pesticide Science, Nanjing Agricultural University, Nanjing 210095, China
Pest Manag Sci 60:167-72. 2004..The results indicated that it is very important to develop and implement effective resistance-management strategies and to detect early resistance to Bt cotton in field populations...
- Common genomic structure for the Lepidoptera cadherin-like genesYolanda Bel
Genetics Department, University of Valencia, Dr Moliner, 50, 46100, Burjassot, Valencia, Spain
Gene 381:71-80. 2006A cadherin-like protein present in the midgut epithelial cells of Lepidoptera is associated with insect resistance to Bacillus thuringiensis Cry toxins...
- Structure-based analysis of the ultraspiracle protein and docking studies of putative ligandsSouphatta Sasorith
, , 1, rue Laurent Fries, 67404 Illkirch, France
J Insect Sci 2:25. 2002..The interaction between the ligand and the receptor are examined in terms of the pocket shape as well as in terms of the chemical nature of the residues lining the ligand binding cavity...
- Food consumption by Chilo partellus (Lepidoptera: Pyralidae) larvae infected with Beauveria bassiana and Metarhizium anisopliae and effects of feeding natural versus artificial diets on mortality and mycosisTadele Tefera
Department of Entomology and Nematology, Private Bag X1, Matieland 7602, South Africa
J Invertebr Pathol 84:220-5. 2003..Larvae provided with artificial diet suffered little mortality and mycoses than larvae provided with maize leaves. The LT(50) was longer for larvae provided with artificial diet...
- The evolutionary origin of signa in female Lepidoptera: natural and sexual selection hypothesesCarlos Cordero
Departamento de Ecologia Evolutiva, Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Apdo Post 70 275, Coyoacan 04510, DF, Mexico
J Theor Biol 232:443-9. 2005..wall of the female corpus bursae (structure where males deposit a spermatophore during copulation) of many Lepidoptera that assist in tearing open spermatophores...
- Differential introgression causes genealogical discordance in host races of Acrocercops transecta (Insecta: Lepidoptera)Issei Ohshima
Systematic Entomology, Department of Ecology and Systematics, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
Mol Ecol 19:2106-19. 2010..Thus, the results show that a low level of gene flow coupled with the inflexible female host preference differentiates histories of divergence between maternally and biparentally inherited genes in this host race system...
- The complete mitochondrial genome of the yellow coaster, Acraea issoria (Lepidoptera: Nymphalidae: Heliconiinae: Acraeini): sequence, gene organization and a unique tRNA translocation eventJing Hu
College of Life Sciences, Anhui Normal University, Wuhu, 241000, China
Mol Biol Rep 37:3431-8. 2010In this paper, the complete mitochondrial genome of Acraea issoria (Lepidoptera: Nymphalidae: Heliconiinae: Acraeini) is reported; a circular molecule of 15,245 bp in size. For A...
- Assessing the value of DNA barcodes and other priority gene regions for molecular phylogenetics of LepidopteraJohn James Wilson
Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 5:e10525. 2010Despite apparently abundant amounts of observable variation and species diversity, the order Lepidoptera exhibits a morphological homogeneity that has provided only a limited number of taxonomic characters and led to widespread use of ..
- Feeding mechanisms of adult Lepidoptera: structure, function, and evolution of the mouthpartsHarald W Krenn
Department of Evolutionary Biology, University of Vienna, Vienna, Austria
Annu Rev Entomol 55:307-27. 2010The form and function of the mouthparts in adult Lepidoptera and their feeding behavior are reviewed from evolutionary and ecological points of view...
- Comprehensive gene and taxon coverage elucidates radiation patterns in moths and butterfliesMarko Mutanen
Zoological Museum, Department of Biology, University of Oulu, PO Box 3000, Oulu 90014, Finland
Proc Biol Sci 277:2839-48. 2010b>Lepidoptera (butterflies and moths) represent one of the most diverse animals groups. Yet, the phylogeny of advanced ditrysian Lepidoptera, accounting for about 99 per cent of lepidopteran species, has remained largely unresolved...
- The complete mitochondrial genome of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae)Fang Liao
1 College of Life Sciences, Nankai University, Tianjin 300071, China
Int J Biol Sci 6:172-86. 2010The complete mitochondrial genome (mitogenome) of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae) was determined. The genome is a circular molecule 15 481 bp long...
- Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insectsI M Billas
Genomics and Structural Biology Laboratory, UPR 9004, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, Cité Universitaire de Strasbourg, France
J Biol Chem 276:7465-74. 2001..The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides...
- Population genetics of ecological communities with DNA barcodes: an example from New Guinea LepidopteraKathleen J Craft
Department of Plant Biology, University of Minnesota, Saint Paul, MN 55108, USA
Proc Natl Acad Sci U S A 107:5041-6. 2010..Contradictory estimates of host specificity and beta diversity in tropical Lepidoptera (moths and butterflies) from New Guinea and the Americas have sparked debate on the role of host-associated ..
- Molecular characterization of a defensin in the IZD-MB-0503 cell line derived from immunocytes of the insect Mamestra brassicae (Lepidoptera)Mauro Mandrioli
Department of Animal Biology, Via Campi 213/D, 41100 Modena, Italy
Biol Cell 95:53-7. 2003..of a defensin-like molecule active against Gram positive bacteria is described for the first time in Lepidoptera. This molecule shows between 43% and 59% homology with group A defensins from other dipteran and hymenopteran ..
- Anopheles gambiae alkaline phosphatase is a functional receptor of Bacillus thuringiensis jegathesan Cry11Ba toxinGang Hua
Department of Entomology, University of Georgia, Athens, Georgia 30602 2603, USA
Biochemistry 48:9785-93. 2009..In bioassays against An. gambiae larvae, the presence of AgALP1(t) reduced larval mortality from 78 to 8%. We conclude that AgALP1 is a binding protein and a functional receptor for Cry11Ba toxin...
- Barcoding lepidoptera: current situation and perspectives on the usefulness of a contentious techniqueKarina L Silva-Brandão
Depto de Entomologia e Acarologia, Escola Superior de Agricultura Luiz de Queiroz, Univ de São Paulo, Piracicaba, SP
Neotrop Entomol 38:441-51. 2009..For insects of the order Lepidoptera neither side seems totally correct or wrong, and although many groups of lepidopterans have been taxonomically ..
- [Molecular and morphological differentiation of Oleria makrena (Hewitson) and Oleria fumata (Haensch) (Lepidoptera: Ithomiinae)]Luz M Gómez-P
Grupo Sistemática Molecular, Univ Nacional de Colombia, Antioquia, Colombia
Neotrop Entomol 38:616-23. 2009..The analysis of 579 base pairs (bp) indicated 46 nucleotide differences between both species...
- The evolution of female flightlessness among Ennominae of the Holarctic forest zone (Lepidoptera, Geometridae)Niklas Wahlberg
Laboratory of Genetics, Department of Biology, University of Turku, FIN 20014 Turku, Finland
Mol Phylogenet Evol 55:929-38. 2010..to facilitate the study of the evolution of female flightlessness among the geometrid subfamily Ennominae (Lepidoptera, Geometridae), we carried out a phylogenetic analysis based on a morphological data matrix, and DNA sequences...
- Venom of Pteromalus puparum (Hymenoptera: Pteromalidae) induced endocrine changes in the hemolymph of its host, Pieris rapae (Lepidoptera: Pieridae)Jia Ying Zhu
State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Arch Insect Biochem Physiol 71:45-53. 2009..The results demonstrate that venom alone of this parasitoid wasp can disrupt its host's endocrine system...
- Mannose-binding lectin from yam (Dioscorea batatas) tubers with insecticidal properties against Helicoverpa armigera (Lepidoptera: Noctuidae)Yuki Ohizumi
Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 981 8555, Japan
J Agric Food Chem 57:2896-902. 2009..DB1 was examined for insecticidal activity against Helicoverpa armigera (Lepidoptera: Noctuidae) larvae at different stages of development...
- DNA barcoding the geometrid fauna of Bavaria (Lepidoptera): successes, surprises, and questionsAxel Hausmann
Entomology Department, Zoological Collection of the State of Bavaria, Munich, Germany
PLoS ONE 6:e17134. 2011..The present study provides a comprehensive DNA barcode library for the Geometridae, one of the most diverse of insect families...
- Insecticidal action of Bauhinia monandra leaf lectin (BmoLL) against Anagasta kuehniella (Lepidoptera: Pyralidae), Zabrotes subfasciatus and Callosobruchus maculatus (Coleoptera: Bruchidae)Maria Ligia Rodrigues Macedo
Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Ciencias Naturais, CPTL, Universidade Federal do Mato Grosso do Sul UFMS, Avenida Capitão Olinto Mancini, Tres Lagoas, MS, Brazil
Comp Biochem Physiol A Mol Integr Physiol 146:486-98. 2007..maculatus larvae increased the digestion of potato starch by 25% compared with the control. The transformation of the genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops...
- Coevolution between pathogen-derived proteinases and proteinase inhibitors of host insectsAndreas Vilcinskas
Justus Liebig University of Giessen, Institute of Phytopathology and Applied Zoology at the Interdisciplinary Research Center, Giessen, Germany
Virulence 1:206-14. 2010....
- Candidate chemosensory ionotropic receptors in a LepidopteraV Olivier
INRA, UMR 1272 INRA UPMC PISC Physiologie de l Insecte Signalisation et Communication, Route de Saint Cyr, Versailles, France
Insect Mol Biol 20:189-99. 2011..Our data suggest that we identified members of the insect IR chemosensory receptor family in S. littoralis and we report here the first demonstration of IR expression in Lepidoptera.
- Assessing diversity of diurnal lepidoptera in habitat fragments: testing the efficiency of strip transectsMatthew R Williams
Centre for Ecosystem Diversity and Dynamics, Department of Environmental Biology, Curtin University, PO Box U1987, Perth, Western Australia 6845, Australia
Environ Entomol 37:1313-22. 2008..The abundance of diurnal lepidoptera showed large temporal variation over the flight season and varied to a lesser extent with time of day and ..
- Genome sequence and organization of a nucleopolyhedrovirus isolated from the smaller tea tortrix, Adoxophyes honmaiMadoka Nakai
Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
Virology 316:171-83. 2003..Although gene content analysis failed to support the group II NPVs, phylogenetic trees based on gene sequence and gene order showed AdhoNPV to be closely related to the group II NPVs...
- Identification of receptors of main sex-pheromone components of three Lepidopteran speciesHidefumi Mitsuno
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Eur J Neurosci 28:893-902. 2008....
- Conserved synteny of genes between chromosome 15 of Bombyx mori and a chromosome of Manduca sexta shown by five-color BAC-FISHKen Sahara
Laboratory of Applied Molecular Entomology, Research Institute of Agriculture, Hokkaido University, N9, W9, Kita ku, Sapporo 060 8589, Japan
Genome 50:1061-5. 2007..To achieve higher-throughput comparative mapping using BAC-FISH in Lepidoptera, we developed a protocol for five-color BAC-FISH, which allowed us to map simultaneously 6 different BAC probes ..
- Molecular genetics and evolution of pheromone biosynthesis in LepidopteraWendell L Roelofs
New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
Proc Natl Acad Sci U S A 100:9179-84. 2003A great diversity of pheromone structures are used by moth species (Insecta: Lepidoptera) for long-distance mating signals...
- High-efficiency transformation of Plasmodium falciparum by the lepidopteran transposable element piggyBacBharath Balu
Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
Proc Natl Acad Sci U S A 102:16391-6. 2005..The availability of such an adaptable genetic tool opens the way for much needed forward genetic approaches to study this lethal human parasite...
- Broadening the insecticidal spectrum of Lepidoptera-specific Bacillus thuringiensis strains by chromosomal integration of cry3AChaoyin Yue
Biotechnology Research Center, China Three Gorges University, Yichang, 443002 Hubei, People's Republic of China
Biotechnol Bioeng 91:296-303. 2005..an integrative vector, pBMB-R14E, was constructed, by which the cry3A delta-endotoxin gene highly toxic to Lepidoptera was delivered into a wildtype B. thuringiensis subsp. kurstaki strain YBT1520...
- Association analysis between serotype, cry gene content, and toxicity to Helicoverpa armigera larvae among Bacillus thuringiensis isolates native to SpainClara Martinez
Laboratorio de Entomología Agrícola y Patología de Insectos, Departamento de Producción Agraria, Universidad Publica de Navarra, 31006 Pamplona, Spain
J Invertebr Pathol 90:91-7. 2005..Bioassays against H. armigera larvae showed a wide variation in the insecticidal potency, even among strains sharing the same set of cry genes and within the same serotype...
- Toxicity and mode of action of Bacillus thuringiensis Cry proteins in the Mediterranean corn borer, Sesamia nonagrioides (Lefebvre)Joel González-Cabrera
Departamento de Genetica, Facultad de CC Biológicas, Dr Moliner 50, 46100 Burjassot, Valencia, Spain
Appl Environ Microbiol 72:2594-600. 2006..In terms of resistance management, based on our results and the fact that Cry1Ca is not toxic to Ostrinia nubilalis, we recommend pyramiding of Cry1Ab with Cry1Fa in the same Bt corn plant for better long-term control of corn borers...
- Laboratory and field evaluations of rhodojaponin-III against the imported cabbage worm Pieris rapae (L.) (Lepidoptera: Pieridae)Guohua Zhong
Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou 510642, China
Pest Manag Sci 62:976-81. 2006..5 and 625 mL ha(-1). These results suggest that further research to develop R-III, and extracts from R. molle, as biorational pesticides or as lead compounds for integrated pest management deserve consideration...
- Cry toxin mode of action in susceptible and resistant Heliothis virescens larvaeJuan Luis Jurat-Fuentes
Department of Entomology, University of Georgia, Athens, GA 30602-2603, USA
J Invertebr Pathol 92:166-71. 2006..virescens encodes a cadherin-like protein, a functional Cry1A receptor in Lepidoptera. This manuscript discusses the most updated information on the mode of action of Cry1A toxins obtained from the ..
- Toxicity of Bacillus thuringiensis delta-endotoxins against bean shoot borer (Epinotia aporema Wals.) larvae, a major soybean pest in ArgentinaDiego H Sauka
Bioinsumos Microbianos, Instituto de Microbiología y Zoología Agrícola, INTA, CC No 25 1712 Castelar, Buenos Aires, Argentina
J Invertebr Pathol 94:125-9. 2007..In addition the heterologous competition experiments showed that Cry1Ab and Cry1Ac toxins share a common binding site. Based on these data, we propose that Cry1Ab and Cry1Ac toxins could be used in the biological control of E. aporema...
- Use of Bacillus thuringiensis toxins for control of the cotton pest Earias insulana (Boisd.) (Lepidoptera: Noctuidae)María A Ibargutxi
Laboratorio de Entomología Agrícola y Patología de Insectos, Departamento de Producción Agraria, Universidad Publica de Navarra, 31006 Pamplona, Spain
Appl Environ Microbiol 72:437-42. 2006....
- Larvicidal activities against agricultural pests of transgenic Escherichia coli expressing combinations of four genes from Bacillus thuringiensisVadim Khasdan
Department of Life Sciences, Ben Gurion University of the Negev, PO Box 653, Be er Sheva 84105, Israel
Arch Microbiol 188:643-53. 2007..5- to 140-fold) than their counterparts with P A1 alone, reducing the LC50 values to below 10(7) cells ml(-1)...
- [Insecticide proteic crystals from a native isolate of Bacillus thuringiensis]D H Sauka
Area Bioinsumos Microbianos, IMYZA-INTA, , Castelar, Buenos Aires, Argentina
Rev Argent Microbiol 39:225. 2007
- Baseline susceptibility of tobacco budworm (Lepidoptera: Noctuidae) to Cry1F toxin from Bacillus thuringiensisCarlos A Blanco
USDA ARS, Southern Insect Management Research Unit, Stoneville, MS 38776, USA
J Econ Entomol 101:168-73. 2008....
- Prediction-based protein engineering of domain I of Cry2A entomocidal toxin of Bacillus thuringiensis for the enhancement of toxicity against lepidopteran insectsChandi C Mandal
IIT BREF Biotek, Indian Institute of Technology, Kharagpur 721 302, India
Protein Eng Des Sel 20:599-606. 2007..1-6.6-fold increase in the toxicity of the peptide against three major lepidopteran insect pests of crop plants...
- Comparative study of Bacillus thuringiensis Cry1Aa and Cry1Ac delta-endotoxin activation, inactivation and in situ histopathological effect in Ephestia kuehniella (Lepidoptera: Pyralidae)Souad Rouis
Laboratory of Biopesticides, Centre of Biotechnology of Sfax, P O Box K 3038, Sfax, Tunisia
Mol Biotechnol 38:233-9. 2008..kuehniella tolerance to Cry1Aa toxin. The latter was slightly bound to apical membranes of epithelial cells that remained intact, whereas Cry1Ac was tightly bound to completely damaged cells basal membranes...
- Bacillus thuringiensis in caterpillars and associated materials collected from protected tropical forests in northwestern Costa RicaCésar Rodriguez-Sanchez
Centro de Investigacion en Biologia Celular y Molecular, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, San Jose, Costa Rica
Rev Biol Trop 54:265-71. 2006Bacillus thuringiensis (Bt) synthesizes crystalline inclusions that are toxic to caterpillars (Lepidoptera) and other orders of invertebrates...
- Changes of inheritance mode and fitness in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) along with its resistance evolution to Cry1Ac toxinGe Mei Liang
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China
J Invertebr Pathol 97:142-9. 2008..79, 0.64 and 0.59 in their respective BtR-F(16), BtR-F(34) and BtR-F(87) strains...
- A highly pathogenic strain of Bacillus thuringiensis serovar kurstaki in lepidopteran pestsHatice Kati
Department of Biology, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey
J Microbiol 45:553-7. 2007..Our results show that the B. thuringiensis isolate (Bn1) may prove valuable as a significant microbial control agent against lepidopteran pests...
- Impact of single-gene and dual-gene Bt broccoli on the herbivore Pieris rapae (Lepidoptera: Pieridae) and its pupal endoparasitoid Pteromalus puparum (Hymenoptera: Pteromalidae)Mao Chen
Department of Entomology, NYSAES, Cornell University, Geneva, NY 14456, USA
Transgenic Res 17:545-55. 2008..puparum. Our data suggest that the effects on P. puparum developing in Bt plant-fed P. rapae are mediated by host quality rather than by direct toxicity...
- Leucine transport is affected by Bacillus thuringiensis Cry1 toxins in brush border membrane vesicles from Ostrinia nubilalis Hb (Lepidoptera: Pyralidae) and Sesamia nonagrioides Lefebvre (Lepidoptera: Noctuidae) midgutM Giovanna Leonardi
Dipartimento di Biologia, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
J Membr Biol 214:157-64. 2006..In both species, as in other Lepidoptera, leucine uptake by BBMVs can take place in the absence of cations, but it can also be driven by a K(+) gradient...
- Characterization of a Cry1Ac-receptor alkaline phosphatase in susceptible and resistant Heliothis virescens larvaeJuan L Jurat-Fuentes
Department of Entomology, University of Georgia, Athens, GA 30602-2603, USA
Eur J Biochem 271:3127-35. 2004..virescens larvae confirmed the observation of reduced HvALP levels. We propose HvALP as a Cry1Ac binding protein that is present at reduced levels in brush border membrane vesicles from YHD2 larvae...
- Tolerance to Bacillus thuringiensis endotoxin in immune-suppressed larvae of the flour moth Ephestia kuehniellaM Mahbubur Rahman
Insect Molecular Biology Laboratory, School of Agriculture and Wine, University of Adelaide, Glen Osmond, SA 5064, Australia
J Invertebr Pathol 96:125-32. 2007..Here we show that the lipid carrier lipophorin represents a major component in the gut lumen and interacts with mature Bt-toxin to form a complex...
- The diversity of Bt resistance genes in species of LepidopteraDavid G Heckel
CESAR, Department of Genetics, University of Melbourne, Parkville, VIC 3010, Australia
J Invertebr Pathol 95:192-7. 2007..Thus, resistance to Cry1A toxins in species of Lepidoptera has a complex genetic basis, with at least four distinct, major resistance genes of which three are mapped in ..
- A proteomic approach to study Cry1Ac binding proteins and their alterations in resistant Heliothis virescens larvaeJuan L Jurat-Fuentes
Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN 37996 4560, USA
J Invertebr Pathol 95:187-91. 2007..Our results validate the use of proteomic approaches to identify toxin binding proteins and proteome alterations in resistant insects...
- Knockdown of aminopeptidase-N from Helicoverpa armigera larvae and in transfected Sf21 cells by RNA interference reveals its functional interaction with Bacillus thuringiensis insecticidal protein Cry1AcSwaminathan Sivakumar
International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India
J Biol Chem 282:7312-9. 2007..BIAcore analysis of HaAPN1/Cry1Ac interaction further established HaAPN1 as a ligand for Cry1Ac. This is the first functional demonstration of insect aminopeptidase-N of H. armigera being a receptor of Cry1Ac protein of B. thuringiensis...
- Diversity of Colombian strains of Bacillus thuringiensis with insecticidal activity against dipteran and lepidopteran insectsG Armengol
Biotechnology and Biological Control Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
J Appl Microbiol 102:77-88. 2007..To evaluate the genetic and molecular diversity and insecticidal activity of Bacillus thuringiensis isolates from all the natural regions of Colombia...
- Toxicity and characterization of cotton expressing Bacillus thuringiensis Cry1Ac and Cry2Ab2 proteins for control of lepidopteran pestsS Sivasupramaniam
Monsanto Company, 700 Chesterfield Parkway West, Saint Louis, MO 63017, USA
J Econ Entomol 101:546-54. 2008....
- Expression and characterization of a recombinant Cry1Ac crystal protein with enhanced green fluorescent protein in acrystalliferous Bacillus thuringiensisJ Y Roh
School of Agricultural Biotechnology, Seoul National University, Seoul, Korea
Lett Appl Microbiol 38:393-9. 2004..SIGNIFICANCE AND IMPACT OF THE STUDY: Through the N-terminal fusion expression of EGFP and Cry1Ac, expression and crystallization between the B. thuringiensis crystal protein and a foreign protein were validated...
- Effect of MON810 Bt field corn on Helicoverpa zea (Lepidoptera: Noctuidae) cannibalism and its implications to resistance developmentT A Horner
USDA, APHIS, PPQ, 4700 River Road, Unit 133, Riverdale, MD 20737, USA
J Econ Entomol 96:931-4. 2003..These behavior alterations could increase the selective differential between susceptible individuals and those carrying resistance genes...
- Degradation of the Cry1Ab protein within transgenic Bacillus thuringiensis corn tissue in the fieldC Zwahlen
Zoological Institute, University of Bern, Bern, Switzerland
Mol Ecol 12:765-75. 2003..3% of the initial amount of Cry1Ab toxin was detected. Our results suggest that extended pre- and post-commercial monitoring are necessary to assess the long-term impact of Bt toxin in transgenic plant residues on soil organisms...
- Activity of Bacillus thuringiensis toxins against cocoa pod borer larvaeDjoko Santoso
Biotechnology Research Institute for Estate Crops, Taman Kencana, Bogor, Indonesia
Pest Manag Sci 60:735-8. 2004..Three Cryl proteins with relatively little homology were all found to be toxic, opening perspectives for controlling cocoa pod borer by expression of Cry proteins in transgenic plants...
- Effect of maysin on wild-type, deltamethrin-resistant, and Bt-resistant Helicoverpa armigera (Lepidoptera: Noctuidae)Brian G Rector
USDA ARS, Crop Genetics and Breeding Research Unit, Tifton, GA 31794, USA
J Econ Entomol 96:909-13. 2003..The toxic effect of maysin on the Bt-R and Del-R colonies suggests that physiological mechanisms of H. armigera resistance to Cry1Ac and deltamethrin do not confer cross-resistance to maysin...
- Competition of Bacillus thuringiensis Cry1 toxins for midgut binding sites: a basis for the development and management of transgenic tropical maize resistant to several stemborersCécile Rang
CIRAD, TA40 PS1, Boulevard de la Lironde, 34398, Montpellier 05, France
Curr Microbiol 49:22-7. 2004..Cry1Ea does not recognize any binding site on Diatraea species. Combinations of toxins are proposed to develop transgenic maize resistant to the three stemborers while allowing resistance management...
- Comparative analysis of proteinase activities of Bacillus thuringiensis-resistant and -susceptible Ostrinia nubilalis (Lepidoptera: Crambidae)Huarong Li
Department of Entomology, Kansas State University, Manhattan 66506, USA
Insect Biochem Mol Biol 34:753-62. 2004..Reduced protoxin processing due to decreased activities of Bt protoxin activation proteinases may be associated with resistance to Bt toxin in this resistant strain of O. nubilalis...
- Dual resistance to Bacillus thuringiensis Cry1Ac and Cry2Aa toxins in Heliothis virescens suggests multiple mechanisms of resistanceJuan Luis Jurat-Fuentes
Department of Entomology, University of Georgia, Athens, Georgia 30602-2603, USA
Appl Environ Microbiol 69:5898-906. 2003..These results highlight the genetic potential of H. virescens to become resistant to distinct Cry toxins simultaneously and may question the effectiveness of gene stacking in delaying evolution of resistance...
- Role of Bacillus thuringiensis Cry1 delta endotoxin binding in determining potency during lepidopteran larval developmentAndroulla Gilliland
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
Appl Environ Microbiol 68:1509-15. 2002..The correlation between binding and potency was inconsistent for the species-instar-toxin combinations used in this study, reaffirming the complex mode of action of Cry1 toxins...
- Reconstruction of Bacillus thuringiensis ssp. israelensis Cry11A endotoxin from fragments corresponding to its N- and C-moieties restores its original biological activityL P Revina
Scientific Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow 117545, Russia
Biochemistry (Mosc) 69:181-7. 2004..Thermitase (a serine protease from Thermoactinomyces vulgaris) and insect gut proteases from Diptera and Lepidoptera exhibit the same hydrolytic effect on Cry11A...
- Interaction of Bacillus thuringiensis toxins with larval midgut binding sites of Helicoverpa armigera (Lepidoptera: Noctuidae)Anna Estela
, , , , Spain
Appl Environ Microbiol 70:1378-84. 2004..In contrast, (125)I-Cry1Ab binding was only significantly inhibited by concanavalin A. These results show that Cry1Ac and Cry1Ab use different epitopes for binding to BBMV...
- Development, survival and fitness performance of Helicoverpa zea (Lepidoptera: Noctuidae) in MON810 Bt field cornT A Horner
USDA, APHIS, PPQ, 4700 River Road, Unit 133, Riverdale, MD 20737, USA
J Econ Entomol 96:914-24. 2003..zea populations. Implications of localized population suppression are discussed...
- Bacillus thuringiensis delta-endotoxin binding to brush border membrane vesicles of rice stem borersEdwin P Alcantara
National Institute of Molecular Biology and Biotechnology, University of the Philippines, , Laguna, Philippines
Arch Insect Biochem Physiol 55:169-77. 2004..stem borer (SSB) Chilo suppressalis (Walker) and yellow stem borer (YSB) Scirpophaga incertulas (Walker) (Lepidoptera: Pyralidae)...
- Mutations at the arginine residues in alpha8 loop of Bacillus thuringiensis delta-endotoxin Cry1Ac affect toxicity and binding to Manduca sexta and Lymantria dispar aminopeptidase NM K Lee
Department of Biochemistry, The Ohio State University, Columbus, OH 43210, USA
FEBS Lett 497:108-12. 2001..These data suggest that the two arginine residues in the alpha8 loop region are important in toxicity and APN binding in L. dispar and M. sexta...
- Assessment of experimental Bt events against fall armyworm and corn earworm in field cornG David Buntin
Entomology Department, University of Georgia, Georgia Experiment Station, Griffin, GA 30223, USA
J Econ Entomol 97:259-64. 2004..zea and S. frugiperda would increase the flexibility of planting corn, Zea mays L., and permit double cropping of corn in areas where these pests perennially reach damaging levels...
Research Grants103 found, 100 shown here
- Functional Domains of Bacillus thuringiensis EndotoxinsDONALD DEAN; Fiscal Year: 2007..these toxins bind to specific receptors on the mosquito midgut as recognized in model insect-toxin studies (the Lepidoptera-toxin paradigm); i.e...
- High-throughput Screens for P. falciparum Malaria (RMI)Jon Clardy; Fiscal Year: 2004..Multi-component screens, based on the GFP-assay, will also be developed, identifying chemotypes that reverse drug resistance to previously effective agents. ..
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald Jarvis; Fiscal Year: 2009....
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald L Jarvis; Fiscal Year: 2010....
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED A contact NOOR; Fiscal Year: 2010....
- Mapping Adeno-associated Virus Capsid Structural and Dynamic TransitionsBrian P Bothner; Fiscal Year: 2010..The availability of this information will be valuable for the development of next generation recombinant vectors with improved efficacy. This project aims to fill this dearth in our knowledge base of basic AAV biology. ..
- Molecular Improvement of Bacterial Mosquito LarvicidesBrian A Federici; Fiscal Year: 2010..This is unlikely to be true for any of the other molecular technologies for vector control and disease reduction under development. ..
- PROTEINASE SYSTEMS IN INSECT HEMOLYMPHMichael Kanost; Fiscal Year: 2003..4. Analyze the regulation of plasma proteinases by M. sexta serine protease inhibitors (serpins). ..
- Apoptosis as an anti-viral response in mosquito midgutROLLIE CLEM; Fiscal Year: 2007....
- Genetics and evolution of gene copy number polymorphismErik Dopman; Fiscal Year: 2007..These long-term objectives have been formulated to test specific predictions for genes with variable copies. ..
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2007....
- Structural and Functional Studies on ProteinsJon Clardy; Fiscal Year: 2007..This scan, if successful, would provide functional annotation for the endogenous function of previously characterized small molecules. Finally, some polypeptides with antibiotic activity will be investigated. ..
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2009....
- Molecule-to-gene approaches to new natural productsJon Clardy; Fiscal Year: 2009..This project describes two approaches, which minimize some of the liabilities of traditional natural products discovery techniques that could lead to an important small molecule stream for HTS. ..
- INTERACTIONS BETWEEN PATHOGENS AND ARTHROPOD MIDGUT EPITHELIAL CELLSROLLIE CLEM; Fiscal Year: 2002..The proposed project thus addresses two key aspects of pathogen-arthropod host interactions that are fundamental to the pathogen survival and transmission. ..
- STRUCTURAL STUDIES ON BIOACTIVE NATURAL PRODUCTSJon Clardy; Fiscal Year: 1993..The molecular structure information obtained from this research will be of direct benefit to chemistry, biochemistry and pharmacology. Several of the research targets could become useful drugs for the treatment of human diseases...
- STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXESJon Clardy; Fiscal Year: 1993..The structures of the complexes would be important for basic science and would provide much needed information on the pathway of cytoplasmic signal transduction...
- N-GLYCOSYLATION MECHANISM IN INSECT CELLSDonald Jarvis; Fiscal Year: 2001..This could lead to more effective ways to control medically and agriculturally significant insects and/or the diseases they help to spread, which would have a major impact on worldwide public health. ..
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2001....
- Highly Improved Bacterial Larvicides for Vector ControlBrian Federici; Fiscal Year: 2007..This collaboration has the common goal of having new products based on these recombinant bacteria on the market within five years, sooner if possible. ..
- Target-Based High-Throughput Screens for Plasmodium falciparum MalariaJon Clardy; Fiscal Year: 2007..Here we will develop a new target-based assay to screen structurally diverse small molecule libraries to identify new antimalarial agents to kill the parasite. ..
- STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXESJon Clardy; Fiscal Year: 1999..Structures of both FKBP12-FK506 and cyclophilin A-Cyclphilin A complexes will be studied to design two distinctly different families of dimerizing agents with no affinity for wild type immunophilins. ..
- Molecule-to-gene approaches to new natural productsJon Clardy; Fiscal Year: 2010..This project describes two approaches, which minimize some of the liabilities of traditional natural products discovery techniques that could lead to an important small molecule stream for HTS. ..
- Genetics of speciation in Drosophila pseudoobscuraMOHAMED A NOOR; Fiscal Year: 2010..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- STRUCTURAL STUDIES OF IMMUNOPHILINS AND RELATED PROTEINSJon Clardy; Fiscal Year: 2003..Structures such as fyn SH2-pYEEI/FK506-FKBP52 that illustrate the concept of using borrowed endogenous proteins to moderate the binding of hybrid small molecules. ..
- STRUCTURAL STUDIES OF BIOACTIVE NATURAL PRODUCTSJon Clardy; Fiscal Year: 1980..Activity in an anticancer screen is the most important criterion but other activities such as antibiotic or CNS are also considered. ..
- Genetics of mate discrimination in Drosophila pseudoobscuraMOHAMED NOOR; Fiscal Year: 2007..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- Molecular mechanisms of X. nematophila-nematode interactionHeidi Goodrich Blair; Fiscal Year: 2007..nematophila during colonization, further define a colonization-specific regulon, and expand our knowledge of the role of a ubiquitous transcription factor in the natural ecology of a bacterium. ..
- INTERACTION BETWEEN X NEMATOPHILUS AND ITS HOSTSHeidi Goodrich Blair; Fiscal Year: 2003..This work will provide insight into the genes and gene products that are essential for symbiosis and will aid in the elucidation of the regulation of host interactions in X. nematophilus and other bacteria. ..
- FUNCTIONAL ANALYSIS OF ANTIAPOPTOTIC IAP PROTEINSROLLIE CLEM; Fiscal Year: 2002....
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED NOOR; Fiscal Year: 2009....
- Molecular Improvement of Bacterial Mosquito LarvicidesBrian Federici; Fiscal Year: 2004....
- APPLICATIONS OF NATURAL PRODUCTS TO CHEMICAL BIOLOGYJon Clardy; Fiscal Year: 2005..Approaches to accessing and screening these natural products by heterologously expressing DNA obtained directly from the environment, eDNA, will be developed. ..
- Molecular Improvement of Bacterial Mosquito LarvicidesBrian Federici; Fiscal Year: 2009..abstract_text> ..
- Phenotypic-based high throughput screens-Plasmodium(RMI)Jon Clardy; Fiscal Year: 2005..Identification of cellular factors involved in parasitic invasion and transmission at the host cell erythrocyte is critical for understanding parasitic pathogenesis and should aid in the development of effective chemotherapeutics. ..
- Molecular Improvement of Bacterial Mosquito LarvicidesBrian Federici; Fiscal Year: 2007..abstract_text> ..