Genomes and Genes
Summary: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Publications327 found, 100 shown here
- FlyBase: enhancing Drosophila Gene Ontology annotationsSusan Tweedie
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Nucleic Acids Res 37:D555-9. 2009FlyBase (http://flybase.org) is a database of Drosophila genetic and genomic information...
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypesA H Brand
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Development 118:401-15. 1993..The gene encoding the yeast transcriptional activator GAL4 is inserted randomly into the Drosophila genome to drive GAL4 expression from one of a diverse array of genomic enhancers...
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunityR Medzhitov
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Nature 388:394-7. 1997..We report here the cloning and characterization of a human homologue of the Drosophila toll protein (Toll) which has been shown to induce the innate immune response in adult Drosophila...
- The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adultsB Lemaitre
Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
Cell 86:973-83. 1996The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB)...
- Variant ionotropic glutamate receptors as chemosensory receptors in DrosophilaRichard Benton
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
Cell 136:149-62. 2009..We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs)...
- Elucidation of a universal size-control mechanism in Drosophila and mammalsJixin Dong
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 130:1120-33. 2007..In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately ..
- Regulated functional alternative splicing in DrosophilaJulian P Venables
Universite Montpellier 2, UMR 5535, Institut de Genetique Moleculaire de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
Nucleic Acids Res 40:1-10. 2012..splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-..
- Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sitesBirgit Czermin
Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
Cell 111:185-96. 2002..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
- Hsp90 as a capacitor for morphological evolutionS L Rutherford
Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Nature 396:336-42. 1998..We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is ..
- Role for a bidentate ribonuclease in the initiation step of RNA interferenceE Bernstein
Cold Spring Harbor Laboratory, New York 11724, USA
Nature 409:363-6. 2001..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
- A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43Nicholas A Lanson
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Hum Mol Genet 20:2510-23. 2011..Ectopic expression of human ALS-causing FUS/TLS mutations in Drosophila caused an accumulation of ubiquitinated proteins, neurodegeneration, larval-crawling defect and early lethality...
- Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategyJiyong Liu
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China
J Genet Genomics 39:209-15. 2012..have, step by step, developed powerful genetic tools for manipulating and functionally dissecting the Drosophila genome, but room for improving these technologies and developing new techniques is still large, especially today ..
- Adaptive protein evolution at the Adh locus in DrosophilaJ H McDonald
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
Nature 351:652-4. 1991..DNA sequence data on the Adh locus (encoding alcohol dehydrogenase, EC 18.104.22.168) in three species in the Drosophila melanogaster species subgroup do not fit this expectation; instead, there are more fixed replacement differences ..
- Traces of Drosophila memoryRonald L Davis
Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
Neuron 70:8-19. 2011....
- Polycomb-dependent regulatory contacts between distant Hox loci in DrosophilaFrédéric Bantignies
Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
Cell 144:214-26. 2011In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA...
- Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 22:451-61. 1999We describe a genetic mosaic system in Drosophila, in which a dominant repressor of a cell marker is placed in trans to a mutant gene of interest...
- Drosophila CENH3 is sufficient for centromere formationMaría José Mendiburo
Max Planck Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
Science 334:686-90. 2011..To address this question, we artificially targeted Drosophila CENH3 (CENP-A/CID) as a CID-GFP-LacI fusion protein to stably integrated lac operator (lacO) arrays...
- The PINK1/Parkin pathway regulates mitochondrial morphologyAngela C Poole
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:1638-43. 2008..Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a ..
- Ablation of insulin-producing neurons in flies: growth and diabetic phenotypesEric J Rulifson
Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
Science 296:1118-20. 2002In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain...
- Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsJessica C Greene
Department of Genome Sciences, University of Washington, P O Box 357730, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:4078-83. 2003..To gain insight into the molecular mechanism responsible for selective cell death in AR-JP, we have created a Drosophila model of this disorder...
- Flies without centriolesRenata Basto
The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
Cell 125:1375-86. 2006..The Drosophila protein DSas-4 is related to the human microcephaly protein CenpJ and the C. elegans centriolar protein Sas-4...
- New genes in Drosophila quickly become essentialSidi Chen
Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
Science 330:1682-5. 2010..we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for ..
- The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life spanJi Wu Wang
Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
J Clin Invest 121:4118-26. 2011..Here, we report that Drosophila mutants in which the homolog of FUS is disrupted exhibit decreased adult viability, diminished locomotor speed, ..
- Molecular mechanisms of metabolic regulation by insulin in DrosophilaAurelio A Teleman
German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Biochem J 425:13-26. 2010The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and ..
- Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila speciesRobert K Bradley
Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
PLoS Biol 8:e1000343. 2010..factors that initiate segmentation along the anterior-posterior axis in embryos of two closely related species: Drosophila melanogaster and Drosophila yakuba...
- DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for DrosophilaThilakam Murali
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
Nucleic Acids Res 39:D736-43. 2011DroID (http://droidb.org/), the Drosophila Interactions Database, is a comprehensive public resource for Drosophila gene and protein interactions...
- Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivationColin D Meiklejohn
Department of Biology, University of Rochester, Rochester, New York, United States of America
PLoS Biol 9:e1001126. 2011..How the X chromosome is regulated in the Drosophila melanogaster male germline is unclear...
- Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolutionAnn Shyn Chiang
Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
Curr Biol 21:1-11. 2011..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
- The role of anorexia in resistance and tolerance to infections in DrosophilaJanelle S Ayres
Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
PLoS Biol 7:e1000150. 2009..This suggests that attempts to extend lifespan through diet restriction or the manipulation of pathways mimicking this process will have complicated effects on a host's ability to fight infections...
- A direct role for dual oxidase in Drosophila gut immunityEun Mi Ha
Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman s University, Seoul 120 750, South Korea
Science 310:847-50. 2005..Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for ..
- Pervasive natural selection in the Drosophila genome?Guy Sella
Department of Evolution, Systematics and Ecology, The Hebrew University, Jerusalem, Israel
PLoS Genet 5:e1000495. 2009..Recent evidence from Drosophila, reviewed here, suggests that this view may be invalid...
- Bacterial communities of diverse Drosophila species: ecological context of a host-microbe model systemJames Angus Chandler
Center for Population Biology, Department of Evolution and Ecology, University of California Davis, Davis, California, USA
PLoS Genet 7:e1002272. 2011b>Drosophila melanogaster is emerging as an important model of non-pathogenic host-microbe interactions. The genetic and experimental tractability of Drosophila has led to significant gains in our understanding of animal-microbial symbiosis...
- The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPJianbin Huang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Cell 122:421-34. 2005..In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family ..
- The birth and death of microRNA genes in DrosophilaJian Lu
Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
Nat Genet 40:351-5. 2008..We carried out deep sequencing of miRNAs from three species of Drosophila, and obtained 107,000 sequences that map to no fewer than 300 loci that were not previously known...
- The role of site accessibility in microRNA target recognitionMichael Kertesz
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Genet 39:1278-84. 2007..Our study thus demonstrates that target accessibility is a critical factor in microRNA function...
- Shadow enhancers foster robustness of Drosophila gastrulationMichael W Perry
Department of Integrative Biology, University of California Berkeley, CA 94720, USA
Curr Biol 20:1562-7. 2010..These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-result regardless of minor variations in conditions" ...
- Regulatory divergence in Drosophila revealed by mRNA-seqC Joel McManus
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Genome Res 20:816-25. 2010..sequencing, we quantified total and allele-specific mRNA expression levels genome-wide in two closely related Drosophila species (D. melanogaster and D. sechellia) and their F(1) hybrids...
- Regulatory changes underlying expression differences within and between Drosophila speciesPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nat Genet 40:346-50. 2008..of cis- and trans-regulatory changes to variable intra- and interspecific gene expression using four strains of Drosophila melanogaster, three strains of D. simulans and a total of 78 genes...
- A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewalD N Cox
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
Genes Dev 12:3715-27. 1998..We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter ..
- High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in DrosophilaRyan T Birse
NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Cell Metab 12:533-44. 2010..Here, we use Drosophila to test the hypothesis that HFD-induced obesity and associated cardiac complications have early evolutionary ..
- Molecular, anatomical, and functional organization of the Drosophila olfactory systemAfrica Couto
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
Curr Biol 15:1535-47. 2005..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
- Parallels between tissue repair and embryo morphogenesisPaul Martin
Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Development 131:3021-34. 2004..to repair an embryonic epithelial wound as is involved during the morphogenetic episodes of dorsal closure in Drosophila and eyelid fusion in the mouse foetus...
- RNA toxicity is a component of ataxin-3 degeneration in DrosophilaLing Bo Li
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
Nature 453:1107-11. 2008..Here we provide evidence for a pathogenic role of the CAG repeat RNA in polyQ toxicity using Drosophila. In a Drosophila screen for modifiers of polyQ degeneration induced by the spinocerebellar ataxia type 3 (SCA3) ..
- CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in DrosophilaChristiane Zweier
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
Am J Hum Genet 85:655-66. 2009..Using Drosophila as a model, we now show that, as known for fly Nrx-I, the CASPR2 ortholog Nrx-IV might also localize to synapses...
- A comprehensive map of insulator elements for the Drosophila genomeNicolas Negre
Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
PLoS Genet 6:e1000814. 2010..CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila embryos. We identify over 14,000 putative insulators, including all classically defined insulators...
- Drosophila innate immunity: an evolutionary perspectiveJules A Hoffmann
CNRS, Institute of Molecular and Cellular Biology, 15 rue Descartes, 67000 Strasbourg, France
Nat Immunol 3:121-6. 2002In response to microbial infections, Drosophila mounts a multifaceted immune response involving humoral reactions that culminate in the destruction of invading organisms by lytic peptides...
- Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndromeSean M J McBride
Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuron 45:753-64. 2005..A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to ..
- Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservationEmily E Hare
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
PLoS Genet 4:e1000106. 2008..locus from six species of scavenger flies (Sepsidae) that are highly diverged from the model species Drosophila melanogaster, but share its basic patterns of developmental gene expression...
- Spatiotemporal rescue of memory dysfunction in DrosophilaSean E McGuire
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 302:1765-8. 2003We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect...
- Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndromeH Hahn
Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
Cell 85:841-51. 1996..A human sequence (PTC) with strong homology to the Drosophila segment polarity gene, patched, was isolated from a YAC and cosmid contig of the NBCCS region...
- Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAiRalph A Neumüller
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
Cell Stem Cell 8:580-93. 2011..we use genome-wide transgenic RNAi to identify 620 genes potentially involved in controlling this balance in Drosophila neuroblasts...
- Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALSPatricia S Estes
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
Hum Mol Genet 20:2308-21. 2011..within TDP-43, efforts have been directed towards generating animal models of ALS in mouse, zebrafish, Drosophila and worms...
- Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signalingSeung Chul Shin
School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151 742, South Korea
Science 334:670-4. 2011..of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and ..
- Drosophila dosage compensation: a complex voyage to the X chromosomeMarnie E Gelbart
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Development 136:1399-410. 2009..In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating ..
- Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystemsAna F Silbering
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
J Neurosci 31:13357-75. 2011..We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs)...
- Evolution in the fast lane: rapidly evolving sex-related genes in DrosophilaWilfried Haerty
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 177:1321-35. 2007A large portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome...
- Molecular evolution and functional characterization of Drosophila insulin-like peptidesSebastian Gronke
Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000857. 2010..Invertebrate genomes often contain multiple genes encoding insulin-like ligands, including seven Drosophila insulin-like peptides (DILPs)...
- Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size changeAdam Eyre-Walker
Centre for the Study of Evolution and School of Life Sciences, University of Sussex, Brighton, United Kingdom
Mol Biol Evol 26:2097-108. 2009..We analyze several data sets of protein-coding genes and noncoding regions from hominids and Drosophila. In Drosophila genes, we estimate that approximately 50% of amino acid substitutions and approximately 20% of ..
- Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathwayMegha Ghildiyal
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
RNA 16:43-56. 2010..Here, we show that while most Drosophila miRNAs are bound to Ago1, miRNA* strands accumulate bound to Ago2...
- A Drosophila model for TDP-43 proteinopathyYan Li
Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 107:3169-74. 2010....
- puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaE Martin-Blanco
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
Genes Dev 12:557-70. 1998..Here, we describe a new member of this family encoded by the puckered gene of Drosophila. Mutations in this gene lead to cytoskeletal defects that result in a failure in dorsal closure related to those ..
- Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila hostZhiyong Xi
Department of Entomology University of Kentucky Lexington, KY 40546, USA
BMC Genomics 9:1. 2008..Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown...
- The carnegie protein trap library: a versatile tool for Drosophila developmental studiesMichael Buszczak
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
Genetics 175:1505-31. 2007..Using transposon mutagenesis in Drosophila, we constructed a library of 7404 protein trap and enhancer trap lines, the Carnegie collection, to facilitate ..
- Gene regulatory networks in the evolution and development of the heartEric N Olson
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Science 313:1922-7. 2006..The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity...
- An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in DrosophilaDaniel Olivieri
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Vienna, Austria
EMBO J 29:3301-17. 2010In Drosophila, PIWI proteins and bound PIWI-interacting RNAs (piRNAs) form the core of a small RNA-mediated defense system against selfish genetic elements...
- Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferationNicolas Buchon
Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Cell Host Microbe 5:200-11. 2009Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection...
- On the utility of short intron sequences as a reference for the detection of positive and negative selection in DrosophilaJohn Parsch
Department of Biology II, University of Munich, Planegg Martinsried, Germany
Mol Biol Evol 27:1226-34. 2010..In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding ..
- Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRsMichael Schnall-Levin
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, 02139, USA
Proc Natl Acad Sci U S A 107:15751-6. 2010..We show that, in Drosophila, preferentially conserved miRNA targeting in ORFs is as widespread as it is in 3'UTRs and that, while far less ..
- Localization of apical epithelial determinants by the basolateral PDZ protein ScribbleD Bilder
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 403:676-80. 2000..b>Drosophila proteins that confer apical membrane identity have been found, but the mechanisms that restrict these ..
- Neuronal control of Drosophila courtship songAnne C von Philipsborn
Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
Neuron 69:509-22. 2011The courtship song of the Drosophila male serves as a genetically tractable model for the investigation of the neural mechanisms of decision-making, action selection, and motor pattern generation...
- Functional siRNAs and miRNAs exhibit strand biasAnastasia Khvorova
Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
Cell 115:209-16. 2003..Together, these results suggest that the thermodynamic properties of siRNA play a critical role in determining the molecule's function and longevity, possibly biasing the steps involved in duplex unwinding and strand retention by RISC...
- Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteinsRenee Smart
School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia
Insect Biochem Mol Biol 38:770-80. 2008Olfaction in Drosophila is mediated by a large family of membrane-bound odorant receptor proteins (Ors)...
- Origins and evolution of microRNA genes in Drosophila speciesMasafumi Nozawa
Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, University Park, USA
Genome Biol Evol 2:180-9. 2010..into the origins and evolutionary patterns of miR genes, we have identified miR genes in the genomes of 12 Drosophila species by bioinformatics approaches and examined their evolutionary changes...
- Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in DrosophilaTomoatsu Ikeya
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Biol 12:1293-300. 2002The insulin/IGF-1 signaling pathway controls cellular and organismal growth in many multicellular organisms. In Drosophila, genetic defects in components of the insulin signaling pathway produce small flies that are delayed in development ..
- Evolutionary changes in cis and trans gene regulationPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 430:85-8. 2004..the distribution of cis- and trans-regulatory changes underlying expression differences between closely related Drosophila species, D. melanogaster and D...
- TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97Gillian P Ritson
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:7729-39. 2010..VCP (p97 in mouse, TER94 in Drosophila melanogaster, and CDC48 in Saccharomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with ..
- Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomesArjun Bhutkar
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 179:1657-80. 2008The availability of 12 complete genomes of various species of genus Drosophila provides a unique opportunity to analyze genome-scale chromosomal rearrangements among a group of closely related species...
- Defining the computational structure of the motion detector in DrosophilaDamon A Clark
Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
Neuron 70:1165-77. 2011..Thus, this computational architecture may be widely used to achieve edge selectivity in motion detection...
- Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in DrosophilaKasper Daniel Hansen
Division of Biostatistics, School of Public Health, University of California Berkeley, Berkeley, CA, USA
PLoS Genet 5:e1000525. 2009Alternative mRNA splicing adds a layer of regulation to the expression of thousands of genes in Drosophila melanogaster...
- The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cellsYingyue Yang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People s Republic of China
PLoS Genet 5:e1000444. 2009..We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays a role in the proper maintenance of germline stem ..
- Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genomeMichaela Schwaiger
Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
Genome Res 20:771-80. 2010..At the same time, HP1-mediated repression at constitutive heterochromatin is required to ensure replication of centromeric repeats at the end of S phase...
- Inducing sleep by remote control facilitates memory consolidation in DrosophilaJeffrey M Donlea
Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
Science 332:1571-6. 2011..Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training...
- Hierarchical chemosensory regulation of male-male social interactions in DrosophilaLiming Wang
Division of Biology, California Institute of Technology, Pasadena, California, USA
Nat Neurosci 14:757-62. 2011Pheromones regulate male social behaviors in Drosophila, but the identities and behavioral role(s) of these chemosensory signals, and how they interact, are incompletely understood...
- Pattern, growth, and controlArthur D Lander
Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697 2300, USA
Cell 144:955-69. 2011..By illuminating such principles, systems biology is helping to create a functional framework within which to make sense of the mechanistic complexity of organismal development...
- Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysJ D Axelrod
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 12:2610-22. 1998In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor...
- Role of G-proteins in odor-sensing and CO2-sensing neurons in DrosophilaC Andrea Yao
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520 8074, USA
J Neurosci 30:4562-72. 2010..chemoreceptors, the odor (Or) and gustatory receptor (Gr) families, have been identified in Drosophila (Clyne et al., 1999, 2000; Vosshall et al., 1999)...
- Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviorFabian Feiguin
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
FEBS Lett 583:1586-92. 2009..Here, we report that flies lacking Drosophila TDP-43 appeared externally normal but presented deficient locomotive behaviors, reduced life span and anatomical ..
- Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouseMiriam R Kantorovitz
Department of Mathematics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Dev Cell 17:568-79. 2009..We cross-validate our predictions on 31 regulatory networks in Drosophila and through correlations with gene expression data...
- Positive selection differs between protein secondary structure elements in DrosophilaKate E Ridout
Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
Genome Biol Evol 2:166-79. 2010..we have examined the relationship between protein secondary structure and selection across six species of Drosophila. We find that amino acids that form disordered regions, such as random coils, are far more likely to be under ..
- Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modulesBin Z He
Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, USA
PLoS Genet 7:e1002053. 2011..patterns of single nucleotide polymorphism in the TFBS of well-characterized CRM in two closely related Drosophila species, Drosophila melanogaster and Drosophila simulans...
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsS M Elbashir
Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, , Germany
Nature 411:494-8. 2001..Therefore, 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics...
- FlyMine: an integrated database for Drosophila and Anopheles genomicsRachel Lyne
Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
Genome Biol 8:R129. 2007..Its main focus is genomic and proteomics data for Drosophila and other insects...
- Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in DrosophilaLeah R Sabin
Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell 138:340-51. 2009..To identify additional genes involved in intrinsic antiviral immunity, we screened Drosophila cells for modulators of viral infection using an RNAi library...
- Neural stem cells: balancing self-renewal with differentiationChris Q Doe
Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
Development 135:1575-87. 2008..Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation ..
- Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in DrosophilaJ S Steffan
Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
Nature 413:739-43. 2001..progressive neuronal degeneration induced by polyglutamine repeat expansion, and they reduce lethality in two Drosophila models of polyglutamine disease...
- A single gene causes both male sterility and segregation distortion in Drosophila hybridsNitin Phadnis
Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
Science 323:376-9. 2009..S. subspecies of Drosophila pseudoobscura...
- Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutHuaqi Jiang
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cell 137:1343-55. 2009..We show here that when enterocytes (ECs) in the Drosophila midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines (..
- Expression in aneuploid Drosophila S2 cellsYu Zhang
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Biol 8:e1000320. 2010..We determined copy number and transcript abundance (expression) genome-wide in Drosophila S2 cells by DNA-Seq and RNA-Seq...
- Quantifying adaptive evolution in the Drosophila immune systemDarren J Obbard
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
PLoS Genet 5:e1000698. 2009It is estimated that a large proportion of amino acid substitutions in Drosophila have been fixed by natural selection, and as organisms are faced with an ever-changing array of pathogens and parasites to which they must adapt, we have ..
- COPI complex is a regulator of lipid homeostasisMathias Beller
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Biol 6:e292. 2008..We identified key Drosophila candidate genes for lipid droplet regulation by RNA interference (RNAi) screening with an image segmentation-..
- Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in DrosophilaChristine Kocks
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cell 123:335-46. 2005..We have identified a predicted transmembrane protein, Eater, which is involved in phagocytosis in Drosophila. Transcriptional silencing of the eater gene in a macrophage cell line led to a significant reduction in the ..
- GENETIC ANALYSIS OF POLARITYRuth Steward; Fiscal Year: 2009Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
- PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILAKENT GOLIC; Fiscal Year: 2002..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
- A GENETIC ANALYSIS OF TASTE IN DROSOPHILABeth Gordesky Gold; Fiscal Year: 2007The overall goal of this program is to investigate the genetic basis of taste-guided behavior in Drosophila melanogaster. We are broadly interested in genes that can directly impact complex behaviors...
- Genetic Studies of Optic AtrophyTaosheng Huang; Fiscal Year: 2010..of an effective therapeutic agent for optic atrophies, recently we have generated an Opa1 knockout model in Drosophila. By analyzing phenotypes in the developing and adult Drosophila eyes, we found that the heterozygous mutation of ..
- Regulation of Drosophila arrestins in light adaptationBih Hwa Shieh; Fiscal Year: 2010..modulates arrestin activity to control the output of rhodopsin thereby fine tuning the visual signaling, using Drosophila eye as a model system...
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and invertebrate systems...
- Developmental Regulation of the Cell Cycle in DrosophilaLAURA ANNE LEE; Fiscal Year: 2010..of functional conservation of genes involved in the cell cycle combined with the superb genetics and cytology of Drosophila melanogaster make it an ideal model organism for studying cell-cycle regulation in a developmental context...
- GENETIC DISSECTION OF PHOTOTRANSDUCTIONBaruch Minke; Fiscal Year: 1993..Transgenic Drosophila flies transformed by epitope-tagged and site- directed modified trp gene in a null trp background will be used ..
- REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNINGPaul MacDonald; Fiscal Year: 2003The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
- ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALESMARIANA FEDERICA WOLFNER; Fiscal Year: 2010..Despite their importance, the functions of these proteins are not well understood. We use Drosophila's "Acp" seminal proteins as a model to investigate the mechanisms by which seminal proteins affect females...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2010..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster...
- EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTERMATTHEW WALLENFANG; Fiscal Year: 2007..The research proposed examines the effect of aging on stem cells in the Drosophila testis, which presents 3 major advantages for this type of study...
- Aging specific gene expression in DrosophilaJOHN GERARD TOWER; Fiscal Year: 2010..goal of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster...
- Aging specific gene expression in DrosophilaJohn Tower; Fiscal Year: 2009..goal of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster...
- Mechanisms of receptor protein tyrosine phosphatase signaling in Drosophila develJessica E Treisman; Fiscal Year: 2010..The fruit fly Drosophila offers an attractive model system in which to address the mechanisms of RPTP function in vivo...
- QTLs in DrosophilaEric A Stone; Fiscal Year: 2010..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- QTLs in DrosophilaTrudy Mackay; Fiscal Year: 2009..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- QTLs in DrosophilaTrudy Mackay; Fiscal Year: 2009..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- Translational regulation of cellular morphogenesis in early Drosophila embryosPaul M Macdonald; Fiscal Year: 2010..to elucidate the mRNA translational regulatory mechanisms that control cellular morphogenesis in cleavage stage Drosophila embryos...
- Somatic stem cells in the Drosophila ovaryDANIEL D KALDERON; Fiscal Year: 2010..Most stem cell niches are hard to access or define. The Drosophila ovary, in which germline and somatic stem cell progeny collaborate to produce eggs, provides an exception that ..
- MOLECULAR GENETICS OF PHOTOTRANSDUCTIONBih Hwa Shieh; Fiscal Year: 2000DESCRIPTION: The investigator will use phototransduction in Drosophila as a model system to understand the coordination of the activation and deactivation processes of signal transduction...
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010Synaptic target selection in Drosophila Abstract: Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and ..
- MOLECULAR GENETICS OF AXON GUIDANCE IN THE DROSOPHILAKai Zinn; Fiscal Year: 1993..suitable for cell biology studies, such as the grasshopper, and species with well-developed genetics, such as Drosophila. A variety of data suggest that individual axons or axon bundles in insect segmental ganglia are differentially ..
- Drosophila as a model genetic system to study neuropsychiatric disordersCharles Nichols; Fiscal Year: 2007..hypothesis of our research is that molecular events initiated by agents acting at serotonin receptors in Drosophila, and other animal models, represent potential candidates for involvement in the development and etiology of ..
- HCO3-transporters in Drosophila and MosquitoesMICHAEL ROMERO; Fiscal Year: 2003..Recently we have cloned a Na+-driven anion exchangers (NDAE1) from Drosophila and immunolocalized NDAE1 to epithelia (gut, Malpighian tubules and salivary glands) as well as the central and ..
- Identifying Cardiomyopathy Genes in Mice and DrosophilaHoward Rockman; Fiscal Year: 2009..that the powerful mutagen, N-ethyl-N- nitrosourea (ENU), mutagenesis in mice, and gene-deletion screens in Drosophila, will lead to the discovery of novel disease-causing and disease-modifying genes for human heart failure...
- Identifying Cardiomyopathy Genes in Mice and DrosophilaHoward Rockman; Fiscal Year: 2007..that the powerful mutagen, N-ethyl-N- nitrosourea (ENU), mutagenesis in mice, and gene-deletion screens in Drosophila, will lead to the discovery of novel disease-causing and disease-modifying genes for human heart failure...
- CELLULAR COMMUNICATION IN MORPHOGENESISMark Krasnow; Fiscal Year: 2003This is a proposal to identify and characterize response pathways in Drosophila cells that are triggered by lack of oxygen (hypoxia). During the previous funding period, Dr...