drosophila

Summary

Summary: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

Top Publications

  1. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
  3. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
  4. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
  5. pmc Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
    Cell 136:149-62. 2009
  6. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
  7. pmc Regulated functional alternative splicing in Drosophila
    Julian P Venables
    Universite Montpellier 2, UMR 5535, Institut de Genetique Moleculaire de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
    Nucleic Acids Res 40:1-10. 2012
  8. ncbi Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    Birgit Czermin
    Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Cell 111:185-96. 2002
  9. ncbi Role for a bidentate ribonuclease in the initiation step of RNA interference
    E Bernstein
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 409:363-6. 2001
  10. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998

Research Grants

  1. Massively Parallel Brain Imaging
    MARK SCHNITZER; Fiscal Year: 2009
  2. 2007 NIH Director's Pioneer Award Program (DP1)
    Rustem Ismagilov; Fiscal Year: 2009
  3. Tissue Culture Laboratory
    Joseph Goldstein; Fiscal Year: 2009
  4. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN FRYE; Fiscal Year: 2009
  5. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
  6. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
  7. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2010
  8. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
  9. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert Weiss; Fiscal Year: 2009
  10. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010

Detail Information

Publications328 found, 100 shown here

  1. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
    FlyBase (http://flybase.org) is a database of Drosophila genetic and genomic information...
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..The gene encoding the yeast transcriptional activator GAL4 is inserted randomly into the Drosophila genome to drive GAL4 expression from one of a diverse array of genomic enhancers...
  3. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..We report here the cloning and characterization of a human homologue of the Drosophila toll protein (Toll) which has been shown to induce the innate immune response in adult Drosophila...
  4. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB)...
  5. pmc Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
    Cell 136:149-62. 2009
    ..We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs)...
  6. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately ..
  7. pmc Regulated functional alternative splicing in Drosophila
    Julian P Venables
    Universite Montpellier 2, UMR 5535, Institut de Genetique Moleculaire de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
    Nucleic Acids Res 40:1-10. 2012
    ..splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-..
  8. ncbi Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    Birgit Czermin
    Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Cell 111:185-96. 2002
    ..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
  9. ncbi Role for a bidentate ribonuclease in the initiation step of RNA interference
    E Bernstein
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 409:363-6. 2001
    ..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
  10. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998
    ..We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is ..
  11. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
    ..DNA sequence data on the Adh locus (encoding alcohol dehydrogenase, EC 1.1.1.1) in three species in the Drosophila melanogaster species subgroup do not fit this expectation; instead, there are more fixed replacement differences ..
  12. doi Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy
    Jiyong Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China
    J Genet Genomics 39:209-15. 2012
    ..have, step by step, developed powerful genetic tools for manipulating and functionally dissecting the Drosophila genome, but room for improving these technologies and developing new techniques is still large, especially today ..
  13. doi A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43
    Nicholas A Lanson
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Hum Mol Genet 20:2510-23. 2011
    ..Ectopic expression of human ALS-causing FUS/TLS mutations in Drosophila caused an accumulation of ubiquitinated proteins, neurodegeneration, larval-crawling defect and early lethality...
  14. doi Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
    Frédéric Bantignies
    Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
    Cell 144:214-26. 2011
    In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA...
  15. pmc Traces of Drosophila memory
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 70:8-19. 2011
    ....
  16. ncbi Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
    We describe a genetic mosaic system in Drosophila, in which a dominant repressor of a cell marker is placed in trans to a mutant gene of interest...
  17. doi Drosophila CENH3 is sufficient for centromere formation
    María José Mendiburo
    Max Planck Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Science 334:686-90. 2011
    ..To address this question, we artificially targeted Drosophila CENH3 (CENP-A/CID) as a CID-GFP-LacI fusion protein to stably integrated lac operator (lacO) arrays...
  18. pmc The PINK1/Parkin pathway regulates mitochondrial morphology
    Angela C Poole
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:1638-43. 2008
    ..Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a ..
  19. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain...
  20. pmc Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
    Jessica C Greene
    Department of Genome Sciences, University of Washington, P O Box 357730, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:4078-83. 2003
    ..To gain insight into the molecular mechanism responsible for selective cell death in AR-JP, we have created a Drosophila model of this disorder...
  21. doi New genes in Drosophila quickly become essential
    Sidi Chen
    Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Science 330:1682-5. 2010
    ..we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for ..
  22. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
    ..The Drosophila protein DSas-4 is related to the human microcephaly protein CenpJ and the C. elegans centriolar protein Sas-4...
  23. pmc The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span
    Ji Wu Wang
    Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 121:4118-26. 2011
    ..Here, we report that Drosophila mutants in which the homolog of FUS is disrupted exhibit decreased adult viability, diminished locomotor speed, ..
  24. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2010
    The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and ..
  25. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
    ..factors that initiate segmentation along the anterior-posterior axis in embryos of two closely related species: Drosophila melanogaster and Drosophila yakuba...
  26. ncbi A direct role for dual oxidase in Drosophila gut immunity
    Eun Mi Ha
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman s University, Seoul 120 750, South Korea
    Science 310:847-50. 2005
    ..Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for ..
  27. pmc The role of anorexia in resistance and tolerance to infections in Drosophila
    Janelle S Ayres
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Biol 7:e1000150. 2009
    ..This suggests that attempts to extend lifespan through diet restriction or the manipulation of pathways mimicking this process will have complicated effects on a host's ability to fight infections...
  28. pmc DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila
    Thilakam Murali
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nucleic Acids Res 39:D736-43. 2011
    DroID (http://droidb.org/), the Drosophila Interactions Database, is a comprehensive public resource for Drosophila gene and protein interactions...
  29. doi Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution
    Ann Shyn Chiang
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
    Curr Biol 21:1-11. 2011
    ..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
  30. pmc Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation
    Colin D Meiklejohn
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Biol 9:e1001126. 2011
    ..How the X chromosome is regulated in the Drosophila melanogaster male germline is unclear...
  31. pmc Bacterial communities of diverse Drosophila species: ecological context of a host-microbe model system
    James Angus Chandler
    Center for Population Biology, Department of Evolution and Ecology, University of California Davis, Davis, California, USA
    PLoS Genet 7:e1002272. 2011
    b>Drosophila melanogaster is emerging as an important model of non-pathogenic host-microbe interactions. The genetic and experimental tractability of Drosophila has led to significant gains in our understanding of animal-microbial symbiosis...
  32. ncbi The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    ..In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family ..
  33. ncbi The birth and death of microRNA genes in Drosophila
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
    Nat Genet 40:351-5. 2008
    ..We carried out deep sequencing of miRNAs from three species of Drosophila, and obtained 107,000 sequences that map to no fewer than 300 loci that were not previously known...
  34. ncbi The role of site accessibility in microRNA target recognition
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 39:1278-84. 2007
    ..Our study thus demonstrates that target accessibility is a critical factor in microRNA function...
  35. ncbi Shadow enhancers foster robustness of Drosophila gastrulation
    Michael W Perry
    Department of Integrative Biology, University of California Berkeley, CA 94720, USA
    Curr Biol 20:1562-7. 2010
    ..These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-result regardless of minor variations in conditions" [6]...
  36. pmc Pervasive natural selection in the Drosophila genome?
    Guy Sella
    Department of Evolution, Systematics and Ecology, The Hebrew University, Jerusalem, Israel
    PLoS Genet 5:e1000495. 2009
    ..Recent evidence from Drosophila, reviewed here, suggests that this view may be invalid...
  37. pmc High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    Ryan T Birse
    NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Metab 12:533-44. 2010
    ..Here, we use Drosophila to test the hypothesis that HFD-induced obesity and associated cardiac complications have early evolutionary ..
  38. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004
    ..to repair an embryonic epithelial wound as is involved during the morphogenetic episodes of dorsal closure in Drosophila and eyelid fusion in the mouse foetus...
  39. pmc A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    D N Cox
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 12:3715-27. 1998
    ..We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter ..
  40. pmc Regulatory divergence in Drosophila revealed by mRNA-seq
    C Joel McManus
    Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genome Res 20:816-25. 2010
    ..sequencing, we quantified total and allele-specific mRNA expression levels genome-wide in two closely related Drosophila species (D. melanogaster and D. sechellia) and their F(1) hybrids...
  41. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
    ..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
  42. ncbi Regulatory changes underlying expression differences within and between Drosophila species
    Patricia J Wittkopp
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nat Genet 40:346-50. 2008
    ..of cis- and trans-regulatory changes to variable intra- and interspecific gene expression using four strains of Drosophila melanogaster, three strains of D. simulans and a total of 78 genes...
  43. pmc RNA toxicity is a component of ataxin-3 degeneration in Drosophila
    Ling Bo Li
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Nature 453:1107-11. 2008
    ..Here we provide evidence for a pathogenic role of the CAG repeat RNA in polyQ toxicity using Drosophila. In a Drosophila screen for modifiers of polyQ degeneration induced by the spinocerebellar ataxia type 3 (SCA3) ..
  44. pmc A comprehensive map of insulator elements for the Drosophila genome
    Nicolas Negre
    Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
    PLoS Genet 6:e1000814. 2010
    ..CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila embryos. We identify over 14,000 putative insulators, including all classically defined insulators...
  45. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    ..Using Drosophila as a model, we now show that, as known for fly Nrx-I, the CASPR2 ortholog Nrx-IV might also localize to synapses...
  46. ncbi Drosophila innate immunity: an evolutionary perspective
    Jules A Hoffmann
    CNRS, Institute of Molecular and Cellular Biology, 15 rue Descartes, 67000 Strasbourg, France
    Nat Immunol 3:121-6. 2002
    In response to microbial infections, Drosophila mounts a multifaceted immune response involving humoral reactions that culminate in the destruction of invading organisms by lytic peptides...
  47. ncbi Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
    Sean M J McBride
    Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 45:753-64. 2005
    ..A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to ..
  48. ncbi Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    H Hahn
    Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
    Cell 85:841-51. 1996
    ..A human sequence (PTC) with strong homology to the Drosophila segment polarity gene, patched, was isolated from a YAC and cosmid contig of the NBCCS region...
  49. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect...
  50. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..locus from six species of scavenger flies (Sepsidae) that are highly diverged from the model species Drosophila melanogaster, but share its basic patterns of developmental gene expression...
  51. doi Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling
    Seung Chul Shin
    School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151 742, South Korea
    Science 334:670-4. 2011
    ..of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and ..
  52. doi Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems
    Ana F Silbering
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Neurosci 31:13357-75. 2011
    ..We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs)...
  53. pmc Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi
    Ralph A Neumüller
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell Stem Cell 8:580-93. 2011
    ..we use genome-wide transgenic RNAi to identify 620 genes potentially involved in controlling this balance in Drosophila neuroblasts...
  54. pmc Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS
    Patricia S Estes
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Hum Mol Genet 20:2308-21. 2011
    ..within TDP-43, efforts have been directed towards generating animal models of ALS in mouse, zebrafish, Drosophila and worms...
  55. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    A large portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome...
  56. doi Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change
    Adam Eyre-Walker
    Centre for the Study of Evolution and School of Life Sciences, University of Sussex, Brighton, United Kingdom
    Mol Biol Evol 26:2097-108. 2009
    ..We analyze several data sets of protein-coding genes and noncoding regions from hominids and Drosophila. In Drosophila genes, we estimate that approximately 50% of amino acid substitutions and approximately 20% of ..
  57. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Invertebrate genomes often contain multiple genes encoding insulin-like ligands, including seven Drosophila insulin-like peptides (DILPs)...
  58. pmc Drosophila dosage compensation: a complex voyage to the X chromosome
    Marnie E Gelbart
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Development 136:1399-410. 2009
    ..In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating ..
  59. pmc Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
    Megha Ghildiyal
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 16:43-56. 2010
    ..Here, we show that while most Drosophila miRNAs are bound to Ago1, miRNA* strands accumulate bound to Ago2...
  60. pmc puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    E Martin-Blanco
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Genes Dev 12:557-70. 1998
    ..Here, we describe a new member of this family encoded by the puckered gene of Drosophila. Mutations in this gene lead to cytoskeletal defects that result in a failure in dorsal closure related to those ..
  61. pmc A Drosophila model for TDP-43 proteinopathy
    Yan Li
    Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:3169-74. 2010
    ....
  62. pmc Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host
    Zhiyong Xi
    Department of Entomology University of Kentucky Lexington, KY 40546, USA
    BMC Genomics 9:1. 2008
    ..Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown...
  63. pmc The carnegie protein trap library: a versatile tool for Drosophila developmental studies
    Michael Buszczak
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    Genetics 175:1505-31. 2007
    ..Using transposon mutagenesis in Drosophila, we constructed a library of 7404 protein trap and enhancer trap lines, the Carnegie collection, to facilitate ..
  64. ncbi Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
    ..The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity...
  65. pmc Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs
    Michael Schnall-Levin
    Department of Mathematics, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Proc Natl Acad Sci U S A 107:15751-6. 2010
    ..We show that, in Drosophila, preferentially conserved miRNA targeting in ORFs is as widespread as it is in 3'UTRs and that, while far less ..
  66. pmc An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila
    Daniel Olivieri
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Vienna, Austria
    EMBO J 29:3301-17. 2010
    In Drosophila, PIWI proteins and bound PIWI-interacting RNAs (piRNAs) form the core of a small RNA-mediated defense system against selfish genetic elements...
  67. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
    ..b>Drosophila proteins that confer apical membrane identity have been found, but the mechanisms that restrict these ..
  68. pmc On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila
    John Parsch
    Department of Biology II, University of Munich, Planegg Martinsried, Germany
    Mol Biol Evol 27:1226-34. 2010
    ..In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding ..
  69. ncbi Functional siRNAs and miRNAs exhibit strand bias
    Anastasia Khvorova
    Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Cell 115:209-16. 2003
    ..Together, these results suggest that the thermodynamic properties of siRNA play a critical role in determining the molecule's function and longevity, possibly biasing the steps involved in duplex unwinding and strand retention by RISC...
  70. pmc Origins and evolution of microRNA genes in Drosophila species
    Masafumi Nozawa
    Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, University Park, USA
    Genome Biol Evol 2:180-9. 2010
    ..into the origins and evolutionary patterns of miR genes, we have identified miR genes in the genomes of 12 Drosophila species by bioinformatics approaches and examined their evolutionary changes...
  71. doi Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins
    Renee Smart
    School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia
    Insect Biochem Mol Biol 38:770-80. 2008
    Olfaction in Drosophila is mediated by a large family of membrane-bound odorant receptor proteins (Ors)...
  72. doi Neuronal control of Drosophila courtship song
    Anne C von Philipsborn
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Neuron 69:509-22. 2011
    The courtship song of the Drosophila male serves as a genetically tractable model for the investigation of the neural mechanisms of decision-making, action selection, and motor pattern generation...
  73. ncbi Evolutionary changes in cis and trans gene regulation
    Patricia J Wittkopp
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 430:85-8. 2004
    ..the distribution of cis- and trans-regulatory changes underlying expression differences between closely related Drosophila species, D. melanogaster and D...
  74. ncbi Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    Tomoatsu Ikeya
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 12:1293-300. 2002
    The insulin/IGF-1 signaling pathway controls cellular and organismal growth in many multicellular organisms. In Drosophila, genetic defects in components of the insulin signaling pathway produce small flies that are delayed in development ..
  75. pmc TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97
    Gillian P Ritson
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:7729-39. 2010
    ..VCP (p97 in mouse, TER94 in Drosophila melanogaster, and CDC48 in Saccharomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with ..
  76. pmc Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes
    Arjun Bhutkar
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 179:1657-80. 2008
    The availability of 12 complete genomes of various species of genus Drosophila provides a unique opportunity to analyze genome-scale chromosomal rearrangements among a group of closely related species...
  77. doi Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Cell Host Microbe 5:200-11. 2009
    Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection...
  78. ncbi A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    D Tautz
    Institut fur Genetik, Mikrobiologie der Universität München, Federal Republic of Germany
    Chromosoma 98:81-5. 1989
    We have developed a non-radioactive in situ hybridization technique for the localization of RNA in whole mount Drosophila embryos...
  79. pmc Defining the computational structure of the motion detector in Drosophila
    Damon A Clark
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Neuron 70:1165-77. 2011
    ..Thus, this computational architecture may be widely used to achieve edge selectivity in motion detection...
  80. pmc Hierarchical chemosensory regulation of male-male social interactions in Drosophila
    Liming Wang
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:757-62. 2011
    Pheromones regulate male social behaviors in Drosophila, but the identities and behavioral role(s) of these chemosensory signals, and how they interact, are incompletely understood...
  81. pmc Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila
    Kasper Daniel Hansen
    Division of Biostatistics, School of Public Health, University of California Berkeley, Berkeley, CA, USA
    PLoS Genet 5:e1000525. 2009
    Alternative mRNA splicing adds a layer of regulation to the expression of thousands of genes in Drosophila melanogaster...
  82. pmc Inducing sleep by remote control facilitates memory consolidation in Drosophila
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    Science 332:1571-6. 2011
    ..Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training...
  83. pmc The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells
    Yingyue Yang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS Genet 5:e1000444. 2009
    ..We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays a role in the proper maintenance of germline stem ..
  84. pmc Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome
    Michaela Schwaiger
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Genome Res 20:771-80. 2010
    ..At the same time, HP1-mediated repression at constitutive heterochromatin is required to ensure replication of centromeric repeats at the end of S phase...
  85. pmc Pattern, growth, and control
    Arthur D Lander
    Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697 2300, USA
    Cell 144:955-69. 2011
    ..By illuminating such principles, systems biology is helping to create a functional framework within which to make sense of the mechanistic complexity of organismal development...
  86. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
    In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor...
  87. pmc Positive selection differs between protein secondary structure elements in Drosophila
    Kate E Ridout
    Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
    Genome Biol Evol 2:166-79. 2010
    ..we have examined the relationship between protein secondary structure and selection across six species of Drosophila. We find that amino acids that form disordered regions, such as random coils, are far more likely to be under ..
  88. doi Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
    Fabian Feiguin
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    FEBS Lett 583:1586-92. 2009
    ..Here, we report that flies lacking Drosophila TDP-43 appeared externally normal but presented deficient locomotive behaviors, reduced life span and anatomical ..
  89. pmc Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila
    C Andrea Yao
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520 8074, USA
    J Neurosci 30:4562-72. 2010
    ..chemoreceptors, the odor (Or) and gustatory receptor (Gr) families, have been identified in Drosophila (Clyne et al., 1999, 2000; Vosshall et al., 1999)...
  90. pmc Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse
    Miriam R Kantorovitz
    Department of Mathematics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dev Cell 17:568-79. 2009
    ..We cross-validate our predictions on 31 regulatory networks in Drosophila and through correlations with gene expression data...
  91. pmc Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules
    Bin Z He
    Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, USA
    PLoS Genet 7:e1002053. 2011
    ..patterns of single nucleotide polymorphism in the TFBS of well-characterized CRM in two closely related Drosophila species, Drosophila melanogaster and Drosophila simulans...
  92. ncbi Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    S M Elbashir
    Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, , Germany
    Nature 411:494-8. 2001
    ..Therefore, 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics...
  93. pmc Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 137:1343-55. 2009
    ..We show here that when enterocytes (ECs) in the Drosophila midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines (..
  94. pmc Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila
    Leah R Sabin
    Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 138:340-51. 2009
    ..To identify additional genes involved in intrinsic antiviral immunity, we screened Drosophila cells for modulators of viral infection using an RNAi library...
  95. pmc Quantifying adaptive evolution in the Drosophila immune system
    Darren J Obbard
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    PLoS Genet 5:e1000698. 2009
    It is estimated that a large proportion of amino acid substitutions in Drosophila have been fixed by natural selection, and as organisms are faced with an ever-changing array of pathogens and parasites to which they must adapt, we have ..
  96. pmc Expression in aneuploid Drosophila S2 cells
    Yu Zhang
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 8:e1000320. 2010
    ..We determined copy number and transcript abundance (expression) genome-wide in Drosophila S2 cells by DNA-Seq and RNA-Seq...
  97. ncbi Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    J S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
    Nature 413:739-43. 2001
    ..progressive neuronal degeneration induced by polyglutamine repeat expansion, and they reduce lethality in two Drosophila models of polyglutamine disease...
  98. doi Neural stem cells: balancing self-renewal with differentiation
    Chris Q Doe
    Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
    Development 135:1575-87. 2008
    ..Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation ..
  99. pmc COPI complex is a regulator of lipid homeostasis
    Mathias Beller
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 6:e292. 2008
    ..We identified key Drosophila candidate genes for lipid droplet regulation by RNA interference (RNAi) screening with an image segmentation-..
  100. pmc A single gene causes both male sterility and segregation distortion in Drosophila hybrids
    Nitin Phadnis
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
    Science 323:376-9. 2009
    ..S. subspecies of Drosophila pseudoobscura...
  101. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..We have identified a predicted transmembrane protein, Eater, which is involved in phagocytosis in Drosophila. Transcriptional silencing of the eater gene in a macrophage cell line led to a significant reduction in the ..

Research Grants146 found, 100 shown here

  1. Massively Parallel Brain Imaging
    MARK SCHNITZER; Fiscal Year: 2009
    ..I have chosen the fruit fly, Drosophila melanogaster, because of its small brain, its sophisticated behavioral repertoire, the large number of strains ..
  2. 2007 NIH Director's Pioneer Award Program (DP1)
    Rustem Ismagilov; Fiscal Year: 2009
    ..These two technologies will be used together to understand protein aggregation and aging, and may lead to new hypothesis and molecules for controlling these processes. ..
  3. Tissue Culture Laboratory
    Joseph Goldstein; Fiscal Year: 2009
    ..Huh-7 hepatoma cells, SV-40 transformed fibroblasts (SV-589), Sf9 insect cells, High Five insect cells, and Drosophila S2 cells...
  4. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN FRYE; Fiscal Year: 2009
    ..This proposal specifically aims to develop potent antagonists of methyl-lysine recognition by human and Drosophila MBT domain containing proteins in order to permit exploration of the biological consequences of blocking this ..
  5. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster...
  6. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..This proposal specifically aims to develop potent antagonists of methyl-lysine recognition by human and Drosophila MBT domain containing proteins in order to permit exploration of the biological consequences of blocking this ..
  7. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2010
    ..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster...
  8. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..and Kim Woodrow of the Yale University Department of Bioengineering, we have shown that antennapedia (AP), a Drosophila transcription factor that facilitates uptake of peptides and oligonucleotides into mammalian cells, when ..
  9. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert Weiss; Fiscal Year: 2009
    ..and Kim Woodrow of the Yale University Department of Bioengineering, we have shown that antennapedia (AP), a Drosophila transcription factor that facilitates uptake of peptides and oligonucleotides into mammalian cells, when ..
  10. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
  11. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..D., and fellowship studies, and in particular previous experience studying Drosophila melanogaster, by developing new scientific skills in physiology and biochemistry...
  12. ANALYSIS OF DROSOPHILA Hsp27 IN DEVELOPMENTALLY REGULATED APOPTOSIS
    Jonathan S Minden; Fiscal Year: 2010
    ..research is to understand the early protein changes that occur during developmentally regulated apoptosis in Drosophila embryos...
  13. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..findings that enzymes of the sphingolipid biosynthetic pathway and their metabolites are important regulators of Drosophila photoreceptor structure, function, and modulation of this pathway can suppress retinal degeneration in a set of ..
  14. Genetic control of limb development by Pbx
    Licia Selleri; Fiscal Year: 2010
    ..The Pbx1 TALE homeodomain protein is a homolog of Drosophila extradenticle (Exd), which has critical roles in patterning of the fly body...
  15. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..The respiratory (tracheal) system of the Drosophila larva has provided a useful genetic model for the study of the development of complex branched tubular networks...
  16. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2010
    ..RIC8 is required for asymmetric cell division in both Caenorhabditis elegans and Drosophila. Loss of ric8 leads to reduced levels of G proteins in Drosophila, suggesting a chaperone function in addition ..
  17. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2010
    ..A search of the CRISP database for the words "Drosophila" and "sleep" lists 38 NIH programs...
  18. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2010
    ..The VRK1 orthologs in Drosophila and C. elegans are essential proteins whose disruption causes sterility associated with meiotic defects...
  19. BMP signaling in vertebrate development
    Ken W Y Cho; Fiscal Year: 2013
    ..We have recently provided evidence that the evolutionarily conserved orthologs of the Drosophila gene schnurri encode a common partner that may be used more widely to promote BMP target gene recognition...
  20. CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITY
    Tej K Pandita; Fiscal Year: 2009
    ..Recently, we have identified a chromatin-modifying factor "hMOF" the human ortholog of Drosophila MOF gene (males absent on the first) that is essential for early embryonic survival in mice...
  21. CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITY
    Tej K Pandita; Fiscal Year: 2010
    ..Recently, we have identified a chromatin-modifying factor "hMOF" the human ortholog of Drosophila MOF gene (males absent on the first) that is essential for early embryonic survival in mice...
  22. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..The results guide which putative epilepsy genes have priority for studies of functions and disease mechanisms in Drosophila melanogaster (Aim 3), mice (Aim 2) and humans (Aim 1)...
  23. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..Sasanka Ramanadham, WU);(3) Using Drosophila to identify candidate modifiers of glucose toxicity (Dr...
  24. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2010
    ..We have found that ROR?t has transcriptional activity in Drosophila S2 cells, and have exploited this observation to perform a genome-wide RNA interference screen...
  25. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..We have found that ROR?t has transcriptional activity in Drosophila S2 cells, and have exploited this observation to perform a genome-wide RNA interference screen...
  26. Phosphorylation & Function of Inhibitor-2
    DAVID BRAUTIGAN; Fiscal Year: 2009
    ..The phenotype is rescued by co-expression of Inh2 that avoids the RNAi knockdown. In Drosophila there is a single Inh2 gene that is maternally expressed in oocytes and embryos during early stages of ..
  27. Phosphorylation & Function of Inhibitor-2
    David L Brautigan; Fiscal Year: 2010
    ..The phenotype is rescued by co-expression of Inh2 that avoids the RNAi knockdown. In Drosophila there is a single Inh2 gene that is maternally expressed in oocytes and embryos during early stages of ..
  28. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..b>Drosophila melanogaster provides a genetically tractable model system, because the genetic background and environmental ..
  29. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry L Orr Weaver; Fiscal Year: 2010
    ..b>Drosophila is an ideal model organism in which to identify the key regulatory mechanisms and genes that govern ..
  30. Oxidative stress and neurogenetic networks in Drosophila
    ROBERT ANHOLT; Fiscal Year: 2009
    ..b>Drosophila melanogaster provides a genetically tractable model system, because the genetic background and environmental ..
  31. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..Recent studies conducted in human embryonic stem cells and Drosophila melanogaster embryos have identified transcriptional elongation as a widely used alternative control mechanism ..
  32. Interplay between the Endocrine and Innate Systems of Drosphila
    Neal Silverman; Fiscal Year: 2012
    ..This proposal uses the fruit fly Drosophila melanogaster as a model for the study of these interactions...
  33. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..The fruit fly, Drosophila, provides an ideal model for genetic analysis of dorsoventral (DV) patterning and growth of the eye primordium...
  34. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..As MCH is not found in non-vertebrate models like Drosophila and C...
  35. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    ..platform optimized for high-throughput drug screening in situ by generating human diseases in the fruit fly Drosophila. Our whole-organism approach holds the promise of producing better safety and efficacy data than traditional pre-..
  36. Epigenetic mechanisms of TDP43-mediated neurodegeneration
    Amit Berson; Fiscal Year: 2013
    ..question, we recently performed an in-vivo RNAi screen for epigenetic modifiers of neurodegeneration in Drosophila, a powerful genetically amendable animal model...
  37. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey A Simon; Fiscal Year: 2010
    ..genetic and biochemical methods will be used to study the Polycomb group (PcG) transcriptional repressors of Drosophila, which provide one of the premier models for deciphering chromatin mechanisms in development...
  38. A Resource for magnetic resonance and optical imaging
    Ravinder Reddy; Fiscal Year: 2009
    ..SELECTED REFERENCES: Cirelli C, Bushey D, Hill SL, Huber R, Kreber R, Ganetzky B, Tononi G. Reduced sleep in Drosophila Shaker mutants, Nature, in press Tononi G and Cirelli C. Sleep and synaptic homeostasis...
  39. GENETIC ANALYSIS OF POLARITY
    Ruth Steward; Fiscal Year: 2009
    Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
  40. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 1999
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  41. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2002
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  42. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2001
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  43. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2001
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  44. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2000
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  45. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2002
    ..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
  46. A GENETIC ANALYSIS OF TASTE IN DROSOPHILA
    Beth Gordesky Gold; Fiscal Year: 2007
    ..by applicant): The overall goal of this program is to investigate the genetic basis of taste-guided behavior in Drosophila melanogaster. We are broadly interested in genes that can directly impact complex behaviors...
  47. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2010
    ..of an effective therapeutic agent for optic atrophies, recently we have generated an Opa1 knockout model in Drosophila. By analyzing phenotypes in the developing and adult Drosophila eyes, we found that the heterozygous mutation of ..
  48. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2009
    ..of an effective therapeutic agent for optic atrophies, recently we have generated an Opa1 knockout model in Drosophila. By analyzing phenotypes in the developing and adult Drosophila eyes, we found that the heterozygous mutation of ..
  49. Expression control in Drosophila splicing assembly factor RNP-4F
    JACK VAUGHN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Drosophila RNP-4F is an ortholog to human p110, which functions with the pre-mRNA processing (PRP) protein class as a recycling factor to carry U4- and U6-snRNPs to the assembling spliceosome...
  50. DOSAGE COMPENSATION IN DROSOPHILA
    Bruce Baker; Fiscal Year: 1999
    ..clear that the mechanisms of dosage compensation are quite distinct in the three most studied eukaryotic system, Drosophila C. elegans, and man. Drosophila dosage compensates by hyperactivation of the single male X chromosome, C...
  51. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 1999
    ..is to understand how complex patterns of cell differentiation are established in epithelial cells during Drosophila embryonic development...
  52. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2000
    ..is to understand how complex patterns of cell differentiation are established in epithelial cells during Drosophila embryonic development...
  53. Regulation of Drosophila arrestins in light adaptation
    Bih Hwa Shieh; Fiscal Year: 2010
    ..modulates arrestin activity to control the output of rhodopsin thereby fine tuning the visual signaling, using Drosophila eye as a model system...
  54. Regulation of Drosophila arrestins in light adaptation
    Bih Hwa Shieh; Fiscal Year: 2009
    ..modulates arrestin activity to control the output of rhodopsin thereby fine tuning the visual signaling, using Drosophila eye as a model system...
  55. Synaptic target selection in Drosophila
    Kai Zinn; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and invertebrate ..
  56. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and invertebrate ..
  57. Establishing Drosophila as a Model to Study Hutchinson-Gilford Progeria Syndrome
    Sandra Schulze; Fiscal Year: 2009
    ..The experiments described in this proposal will establish the fruit fly Drosophila as a model to study human Lamin A processing...
  58. FUNCTIONAL ANALYSIS OF NOVEL GABA RECEPTOR IN DROSOPHILA
    Richard ffrench Constant; Fiscal Year: 1999
    ..recently identified a novel GABA receptor subunit gene Rdl (Resistance to dieldrin) that was cloned from a Drosophila mutant resistant to PTX and cyclodiene insecticides...
  59. SYSTEMIC AND EPITHELIAL INSECT IMMUNITY
    JULES HOFFMAN; Fiscal Year: 2000
    ..Our work concentrates on two model dipteran insects, the fruitfly Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae...
  60. SYSTEMIC AND EPITHELIAL INSECT IMMUNITY
    JULES HOFFMAN; Fiscal Year: 2002
    ..Our work concentrates on two model dipteran insects, the fruitfly Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae...
  61. SYSTEMIC AND EPITHELIAL INSECT IMMUNITY
    JULES HOFFMAN; Fiscal Year: 1999
    ..Our work concentrates on two model dipteran insects, the fruitfly Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae...
  62. Developmental Regulation of the Cell Cycle in Drosophila
    LAURA ANNE LEE; Fiscal Year: 2010
    ..of functional conservation of genes involved in the cell cycle combined with the superb genetics and cytology of Drosophila melanogaster make it an ideal model organism for studying cell-cycle regulation in a developmental context...
  63. SYSTEMIC AND EPITHELIAL INSECT IMMUNITY
    JULES HOFFMAN; Fiscal Year: 2001
    ..Our work concentrates on two model dipteran insects, the fruitfly Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae...
  64. GENETIC DISSECTION OF PHOTOTRANSDUCTION
    Baruch Minke; Fiscal Year: 1993
    ..Transgenic Drosophila flies transformed by epitope-tagged and site- directed modified trp gene in a null trp background will be used ..
  65. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul MacDonald; Fiscal Year: 2003
    The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
  66. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul MacDonald; Fiscal Year: 2001
    The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
  67. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul MacDonald; Fiscal Year: 2000
    The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
  68. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul MacDonald; Fiscal Year: 2002
    The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
  69. Generation of Wunen/LPP3-based therapy for muscular dystrophy
    Hannele Ruohola Baker; Fiscal Year: 2009
    ..reduction of LPP3 that reduces the level of active second messenger, S1P can suppress dystrophic phenotypes in Drosophila melanogaster...
  70. Generation of Wunen/LPP3-based therapy for muscular dystrophy
    Hannele Ruohola Baker; Fiscal Year: 2010
    ..reduction of LPP3 that reduces the level of active second messenger, S1P can suppress dystrophic phenotypes in Drosophila melanogaster...
  71. Regulators of tracheal morphogenesis in Drosophila
    Lizabeth Perkins; Fiscal Year: 2001
    ..In vertebrates, the tracheal system of Drosophila is a branching tubular organ conserved at the molecular level; e.g...
  72. Immune Response of Drosophila Against Spiroplasma
    Mariana Mateos; Fiscal Year: 2009
    ..The fruitfly Drosophila melanogaster has provided an unbiased and powerful tool for examination of innate response against many types of ..
  73. A Drosophila Model for Genetic Studies of Metabolism
    CARL THUMMEL; Fiscal Year: 2009
    ..The goal of our research is to use the fruit fly, Drosophila melanogaster, as a simple model system to define the central regulatory pathways that control metabolism and ..
  74. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..The goal of our research is to use the fruit fly, Drosophila melanogaster, as a simple model system to define the central regulatory pathways that control metabolism and ..
  75. Characterizing the R8 cell subtype fate in Drosophila
    Brent S Wells; Fiscal Year: 2012
    ..The compound eye of Drosophila is made up of approximately 800 repeating units called ommatidia and each ommatidia is sub-divided into 20 ..
  76. Characterization of a novel Drosophila disease model for CHARGE Syndrome
    Daniel R Marenda; Fiscal Year: 2010
    ..understanding of the mechanism(s) of pathogenesis of CS through characterization and application of a novel Drosophila model of the disease...