Genomes and Genes
Summary: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Publications287 found, 100 shown here
- FlyBase: enhancing Drosophila Gene Ontology annotationsSusan Tweedie
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Nucleic Acids Res 37:D555-9. 2009FlyBase (http://flybase.org) is a database of Drosophila genetic and genomic information...
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunityR Medzhitov
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Nature 388:394-7. 1997..We report here the cloning and characterization of a human homologue of the Drosophila toll protein (Toll) which has been shown to induce the innate immune response in adult Drosophila...
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypesA H Brand
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Development 118:401-15. 1993..The gene encoding the yeast transcriptional activator GAL4 is inserted randomly into the Drosophila genome to drive GAL4 expression from one of a diverse array of genomic enhancers...
- The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adultsB Lemaitre
Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
Cell 86:973-83. 1996The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB)...
- The PINK1/Parkin pathway regulates mitochondrial morphologyAngela C Poole
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:1638-43. 2008..Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a ..
- Regulatory divergence in Drosophila revealed by mRNA-seqC Joel McManus
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Genome Res 20:816-25. 2010..sequencing, we quantified total and allele-specific mRNA expression levels genome-wide in two closely related Drosophila species (D. melanogaster and D. sechellia) and their F(1) hybrids...
- A Drosophila model for TDP-43 proteinopathyYan Li
Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 107:3169-74. 2010....
- Elucidation of a universal size-control mechanism in Drosophila and mammalsJixin Dong
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 130:1120-33. 2007..In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately ..
- Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsJessica C Greene
Department of Genome Sciences, University of Washington, P O Box 357730, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:4078-83. 2003..To gain insight into the molecular mechanism responsible for selective cell death in AR-JP, we have created a Drosophila model of this disorder...
- Adaptive protein evolution at the Adh locus in DrosophilaJ H McDonald
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
Nature 351:652-4. 1991..DNA sequence data on the Adh locus (encoding alcohol dehydrogenase, EC 220.127.116.11) in three species in the Drosophila melanogaster species subgroup do not fit this expectation; instead, there are more fixed replacement differences ..
- Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila speciesRobert K Bradley
Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
PLoS Biol 8:e1000343. 2010..factors that initiate segmentation along the anterior-posterior axis in embryos of two closely related species: Drosophila melanogaster and Drosophila yakuba...
- Molecular mechanisms of metabolic regulation by insulin in DrosophilaAurelio A Teleman
German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Biochem J 425:13-26. 2010The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and ..
- Drosophila dosage compensation: a complex voyage to the X chromosomeMarnie E Gelbart
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Development 136:1399-410. 2009..In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating ..
- A comprehensive map of insulator elements for the Drosophila genomeNicolas Negre
Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
PLoS Genet 6:e1000814. 2010..CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila embryos. We identify over 14,000 putative insulators, including all classically defined insulators...
- The birth and death of microRNA genes in DrosophilaJian Lu
Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
Nat Genet 40:351-5. 2008..We carried out deep sequencing of miRNAs from three species of Drosophila, and obtained 107,000 sequences that map to no fewer than 300 loci that were not previously known...
- Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 22:451-61. 1999We describe a genetic mosaic system in Drosophila, in which a dominant repressor of a cell marker is placed in trans to a mutant gene of interest...
- Shadow enhancers foster robustness of Drosophila gastrulationMichael W Perry
Department of Integrative Biology, University of California Berkeley, CA 94720, USA
Curr Biol 20:1562-7. 2010..These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-result regardless of minor variations in conditions" ...
- The role of site accessibility in microRNA target recognitionMichael Kertesz
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Genet 39:1278-84. 2007..Our study thus demonstrates that target accessibility is a critical factor in microRNA function...
- RNA toxicity is a component of ataxin-3 degeneration in DrosophilaLing Bo Li
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
Nature 453:1107-11. 2008..Here we provide evidence for a pathogenic role of the CAG repeat RNA in polyQ toxicity using Drosophila. In a Drosophila screen for modifiers of polyQ degeneration induced by the spinocerebellar ataxia type 3 (SCA3) ..
- Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferationNicolas Buchon
Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Cell Host Microbe 5:200-11. 2009Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection...
- Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndromeH Hahn
Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
Cell 85:841-51. 1996..A human sequence (PTC) with strong homology to the Drosophila segment polarity gene, patched, was isolated from a YAC and cosmid contig of the NBCCS region...
- Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservationEmily E Hare
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
PLoS Genet 4:e1000106. 2008..locus from six species of scavenger flies (Sepsidae) that are highly diverged from the model species Drosophila melanogaster, but share its basic patterns of developmental gene expression...
- Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndromeSean M J McBride
Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuron 45:753-64. 2005..A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to ..
- Spatiotemporal rescue of memory dysfunction in DrosophilaSean E McGuire
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 302:1765-8. 2003We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect...
- Evolution in the fast lane: rapidly evolving sex-related genes in DrosophilaWilfried Haerty
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 177:1321-35. 2007A large portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome...
- Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolutionAnn Shyn Chiang
Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
Curr Biol 21:1-11. 2011..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
- Molecular evolution and functional characterization of Drosophila insulin-like peptidesSebastian Gronke
Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000857. 2010..Invertebrate genomes often contain multiple genes encoding insulin-like ligands, including seven Drosophila insulin-like peptides (DILPs)...
- Variant ionotropic glutamate receptors as chemosensory receptors in DrosophilaRichard Benton
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
Cell 136:149-62. 2009..We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs)...
- Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathwayMegha Ghildiyal
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
RNA 16:43-56. 2010..Here, we show that while most Drosophila miRNAs are bound to Ago1, miRNA* strands accumulate bound to Ago2...
- Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRsMichael Schnall-Levin
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, 02139, USA
Proc Natl Acad Sci U S A 107:15751-6. 2010..We show that, in Drosophila, preferentially conserved miRNA targeting in ORFs is as widespread as it is in 3'UTRs and that, while far less ..
- Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size changeAdam Eyre-Walker
Centre for the Study of Evolution and School of Life Sciences, University of Sussex, Brighton, United Kingdom
Mol Biol Evol 26:2097-108. 2009..We analyze several data sets of protein-coding genes and noncoding regions from hominids and Drosophila. In Drosophila genes, we estimate that approximately 50% of amino acid substitutions and approximately 20% of ..
- On the utility of short intron sequences as a reference for the detection of positive and negative selection in DrosophilaJohn Parsch
Department of Biology II, University of Munich, Planegg Martinsried, Germany
Mol Biol Evol 27:1226-34. 2010..In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding ..
- Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila hostZhiyong Xi
Department of Entomology University of Kentucky Lexington, KY 40546, USA
BMC Genomics 9:1. 2008..Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown...
- Gene regulatory networks in the evolution and development of the heartEric N Olson
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Science 313:1922-7. 2006..The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity...
- Ablation of insulin-producing neurons in flies: growth and diabetic phenotypesEric J Rulifson
Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
Science 296:1118-20. 2002In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain...
- The carnegie protein trap library: a versatile tool for Drosophila developmental studiesMichael Buszczak
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
Genetics 175:1505-31. 2007..Using transposon mutagenesis in Drosophila, we constructed a library of 7404 protein trap and enhancer trap lines, the Carnegie collection, to facilitate ..
- Role for a bidentate ribonuclease in the initiation step of RNA interferenceE Bernstein
Cold Spring Harbor Laboratory, New York 11724, USA
Nature 409:363-6. 2001..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
- Pervasive natural selection in the Drosophila genome?Guy Sella
Department of Evolution, Systematics and Ecology, The Hebrew University, Jerusalem, Israel
PLoS Genet 5:e1000495. 2009..Recent evidence from Drosophila, reviewed here, suggests that this view may be invalid...
- Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in DrosophilaTomoatsu Ikeya
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Biol 12:1293-300. 2002The insulin/IGF-1 signaling pathway controls cellular and organismal growth in many multicellular organisms. In Drosophila, genetic defects in components of the insulin signaling pathway produce small flies that are delayed in development ..
- Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomesArjun Bhutkar
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 179:1657-80. 2008The availability of 12 complete genomes of various species of genus Drosophila provides a unique opportunity to analyze genome-scale chromosomal rearrangements among a group of closely related species...
- TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97Gillian P Ritson
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:7729-39. 2010..VCP (p97 in mouse, TER94 in Drosophila melanogaster, and CDC48 in Saccharomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with ..
- Evolutionary changes in cis and trans gene regulationPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 430:85-8. 2004..the distribution of cis- and trans-regulatory changes underlying expression differences between closely related Drosophila species, D. melanogaster and D...
- CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in DrosophilaChristiane Zweier
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
Am J Hum Genet 85:655-66. 2009..Using Drosophila as a model, we now show that, as known for fly Nrx-I, the CASPR2 ortholog Nrx-IV might also localize to synapses...
- Positive selection differs between protein secondary structure elements in DrosophilaKate E Ridout
Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
Genome Biol Evol 2:166-79. 2010..we have examined the relationship between protein secondary structure and selection across six species of Drosophila. We find that amino acids that form disordered regions, such as random coils, are far more likely to be under ..
- Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviorFabian Feiguin
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
FEBS Lett 583:1586-92. 2009..Here, we report that flies lacking Drosophila TDP-43 appeared externally normal but presented deficient locomotive behaviors, reduced life span and anatomical ..
- Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modulesBin Z He
Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, USA
PLoS Genet 7:e1002053. 2011..patterns of single nucleotide polymorphism in the TFBS of well-characterized CRM in two closely related Drosophila species, Drosophila melanogaster and Drosophila simulans...
- Role of G-proteins in odor-sensing and CO2-sensing neurons in DrosophilaC Andrea Yao
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520 8074, USA
J Neurosci 30:4562-72. 2010..chemoreceptors, the odor (Or) and gustatory receptor (Gr) families, have been identified in Drosophila (Clyne et al., 1999, 2000; Vosshall et al., 1999)...
- The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPJianbin Huang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Cell 122:421-34. 2005..In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family ..
- New genes in Drosophila quickly become essentialSidi Chen
Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
Science 330:1682-5. 2010..we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for ..
- Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouseMiriam R Kantorovitz
Department of Mathematics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Dev Cell 17:568-79. 2009..We cross-validate our predictions on 31 regulatory networks in Drosophila and through correlations with gene expression data...
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsS M Elbashir
Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, , Germany
Nature 411:494-8. 2001..Therefore, 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics...
- Quantifying adaptive evolution in the Drosophila immune systemDarren J Obbard
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
PLoS Genet 5:e1000698. 2009It is estimated that a large proportion of amino acid substitutions in Drosophila have been fixed by natural selection, and as organisms are faced with an ever-changing array of pathogens and parasites to which they must adapt, we have ..
- Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in DrosophilaLeah R Sabin
Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell 138:340-51. 2009..To identify additional genes involved in intrinsic antiviral immunity, we screened Drosophila cells for modulators of viral infection using an RNAi library...
- Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in DrosophilaChristine Kocks
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cell 123:335-46. 2005..We have identified a predicted transmembrane protein, Eater, which is involved in phagocytosis in Drosophila. Transcriptional silencing of the eater gene in a macrophage cell line led to a significant reduction in the ..
- FlyMine: an integrated database for Drosophila and Anopheles genomicsRachel Lyne
Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
Genome Biol 8:R129. 2007..Its main focus is genomic and proteomics data for Drosophila and other insects...
- COPI complex is a regulator of lipid homeostasisMathias Beller
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Biol 6:e292. 2008..We identified key Drosophila candidate genes for lipid droplet regulation by RNA interference (RNAi) screening with an image segmentation-..
- A single gene causes both male sterility and segregation distortion in Drosophila hybridsNitin Phadnis
Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
Science 323:376-9. 2009..S. subspecies of Drosophila pseudoobscura...
- Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in DrosophilaJ S Steffan
Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
Nature 413:739-43. 2001..progressive neuronal degeneration induced by polyglutamine repeat expansion, and they reduce lethality in two Drosophila models of polyglutamine disease...
- Expression in aneuploid Drosophila S2 cellsYu Zhang
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Biol 8:e1000320. 2010..We determined copy number and transcript abundance (expression) genome-wide in Drosophila S2 cells by DNA-Seq and RNA-Seq...
- Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virusSpencer Shelly
Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Immunity 30:588-98. 2009..antiviral role against the mammalian viral pathogen vesicular stomatitis virus (VSV) in the model organism Drosophila. We found that the surface glycoprotein, VSV-G, was likely the pathogen-associated molecular pattern (PAMP) that ..
- Neural stem cells: balancing self-renewal with differentiationChris Q Doe
Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
Development 135:1575-87. 2008..Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation ..
- Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutHuaqi Jiang
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cell 137:1343-55. 2009..We show here that when enterocytes (ECs) in the Drosophila midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines (..
- A rapidly evolving homeobox at the site of a hybrid sterility geneC T Ting
Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
Science 282:1501-4. 1998..The exact site of the Odysseus (Ods) locus of hybrid male sterility in Drosophila contains such a homeobox gene...
- decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovaryT Xie
Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Cell 94:251-60. 1998..Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express ..
- The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packingReza Farhadifar
Max Planck Institute for the Physics of Complex Systems, Nothnitzer Strasse 38, 01187 Dresden, Germany
Curr Biol 17:2095-104. 2007..The development of specific packing geometries is tightly controlled; in the Drosophila wing epithelium, cells convert from an irregular to a hexagonal array shortly before hair formation...
- Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemiaTeresa Palomero
Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
Nat Med 13:1203-10. 2007..Notch signaling and the PI3K-AKT pathway synergize in vivo in a Drosophila melanogaster model of Notch-induced tumorigenesis, and mutational loss of PTEN is associated with human T-ALL ..
- Codon usage in twelve species of DrosophilaSaverio Vicario
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8105, USA
BMC Evol Biol 7:226. 2007..g., bacteria, yeast, and Drosophila. Several explanations for CUB have been offered and some have been supported by observations and experiments, ..
- Evolutionary constraint and adaptation in the metabolic network of DrosophilaAnthony J Greenberg
Department of Molecular Biology and Genetics, Cornell University, USA
Mol Biol Evol 25:2537-46. 2008..Taking advantage of the newly available whole-genome sequences of 12 Drosophila species, we examined how protein function and metabolic network architecture influence rates of enzyme evolution...
- Cell death: critical control pointsNika N Danial
Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 116:205-19. 2004..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics...
- Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activationScott J Nowak
Department of Biology, The Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
Trends Genet 20:214-20. 2004..3 variant, which has a conserved N-terminal tail, can replace histone H3 at sites of active transcription, adds a new layer of complexity and possibilities to the regulation of transcription through changes in chromatin structure...
- The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulansLisa Klasson
Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
Proc Natl Acad Sci U S A 106:5725-30. 2009..pipientis strain wRi that induces very strong cytoplasmic incompatibility in its natural host Drosophila simulans. A comparison with the previously sequenced genome of W...
- The molecular basis of CO2 reception in DrosophilaJae Young Kwon
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
Proc Natl Acad Sci U S A 104:3574-8. 2007..Here we show that Gr21a and Gr63a, members of a large family of Drosophila seven-transmembrane-domain chemoreceptor genes, are coexpressed in chemosensory neurons of both the larva and ..
- Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsA Wodarz
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
Nature 402:544-7. 1999..In Drosophila neuroblasts, inscuteable controls both spindle orientation and the asymmetric localization of the cell-fate ..
- Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eyeM Freeman
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Cell 87:651-60. 1996The Drosophila eye has contributed much to our knowledge of cell differentiation...
- Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in DrosophilaChee Hoe Ng
National Neuroscience Institute, Singapore
J Neurosci 29:11257-62. 2009..understand the contribution of different LRRK2 variants toward disease pathogenesis, we generated transgenic Drosophila over-expressing various human LRRK2 alleles, including wild type, G2019S, Y1699C, and G2385R LRRK2...
- Altered localization of Drosophila Smoothened protein activates Hedgehog signal transductionAlan Jian Zhu
Departments of Developmental Biology and Genetics, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
Genes Dev 17:1240-52. 2003..The reception of a Hh signal overcomes Ptc inhibition of Smo, activating transcription of target genes. Using Drosophila salivary gland cells in vivo and in vitro as a new assay for Hh signal transduction, we investigated the ..
- Genome-wide patterns of adaptation to temperate environments associated with transposable elements in DrosophilaJosefa González
Department of Biology, Stanford University, Stanford, California, United States of America
PLoS Genet 6:e1000905. 2010..b>Drosophila is a particularly good model to study adaptation to environmental heterogeneity since it is a tropical species ..
- Tumor suppressor CYLD regulates JNK-induced cell death in DrosophilaLei Xue
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06536, USA
Dev Cell 13:446-54. 2007..To address these questions, we generated Drosophila CYLD (dCYLD) mutant and transgenic flies expressing wild-type and mutant dCYLD proteins...
- Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell lineNelson C Lau
Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
Genome Res 19:1776-85. 2009..We analyzed the Drosophila ovary somatic sheet (OSS) cell line and found that it expresses miRNAs, endogenous small interfering RNAs (endo-..
- Synchronous and stochastic patterns of gene activation in the Drosophila embryoAlistair N Boettiger
Biophysics Program, University of California, Berkeley, CA 94720, USA
Science 325:471-3. 2009b>Drosophila embryogenesis is characterized by rapid transitions in gene activity, whereby crudely distributed gradients of regulatory proteins give way to precise on/off patterns of gene expression...
- Proteomic discovery of previously unannotated, rapidly evolving seminal fluid genes in DrosophilaGeoffrey D Findlay
Department of Genome Sciences, University of Washington, Seattle, WA 98195 5065, USA
Genome Res 19:886-96. 2009..genes encoding seminal fluid proteins (Sfps) that are transferred from males to females during mating in Drosophila. Using bioinformatics, we detected putative orthologs of these genes, as well as 19 others detected by the same ..
- The genomics of speciation in Drosophila: diversity, divergence, and introgression estimated using low-coverage genome sequencingRob J Kulathinal
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
PLoS Genet 5:e1000550. 2009..Here, we examine genomic sequences from closely related fruit fly taxa of the Drosophila pseudoobscura subgroup to reconstruct their evolutionary histories and past patterns of genic exchange...
- HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent mannerGuanjun Gao
LBMB, NCI, NIH, Bethesda, MD 20892, USA
EMBO J 29:819-29. 2010Telomeres prevent chromosome ends from being repaired as double-strand breaks (DSBs). Telomere identity in Drosophila is determined epigenetically with no sequence either necessary or sufficient...
- Multiscale modeling of diffusion in the early Drosophila embryoChristine Sample
Department of Chemical Engineering and Lewis Sigler Institute for Integrative Genomics, Princeton University, Washington Road, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 107:10092-6. 2010..a multiscale approach for the computationally efficient modeling of morphogen gradients in the syncytial Drosophila embryo, a single cell with multiple dividing nuclei...
- Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling speciesJoshua J Bayes
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98185, USA
Science 326:1538-41. 2009..In Drosophila mauritiana x Drosophila simulans male hybrids, OdsH from D...
- The role of the TRP channel NompC in Drosophila larval and adult locomotionLi E Cheng
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 67:373-80. 2010..Taken together, our findings suggest that NompC mediates proprioception in locomotion and support its role as a mechanosensitive channel...
- Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosisG T Lam
Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
Development 124:1757-69. 1997The DHR3 orphan receptor gene is induced directly by the steroid hormone ecdysone at the onset of Drosophila metamorphosis. DHR3 expression peaks in early prepupae, as the early puff genes are repressed and betaFTZ-F1 is induced...
- Requirements for the cytoplasmic domain of the alphaPS1, alphaPS2 and betaPS integrin subunits during Drosophila developmentX Li
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Development 125:701-11. 1998..the functional significance of the cytoplasmic domains of the alphaPS1, alphaPS2 and betaPS subunits of the Drosophila Position Specific (PS) integrin family by analyzing the relationship between cytoplasmic domain structure and ..
- A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wingM Strigini
European Molecular Biology Laboratory, Heidelberg, Germany
Development 124:4697-705. 1997..In Drosophila, Hh has been thought to act primarily to induce localized expression of Decapentaplegic and Wingless which in ..
- Integration of the head and trunk segmentation systems controls cephalic furrow formation in DrosophilaA Vincent
Department of Molecular Biology, Princeton University, New Jersey 08540, USA
Development 124:3747-54. 1997Genetic and molecular analyses of patterning of the Drosophila embryo have shown that the process of segmentation of the head is fundamentally different from the process of segmentation of the trunk...
- Dynamical analysis of the regulatory network defining the dorsal-ventral boundary of the Drosophila wing imaginal discAitor Gonzalez
Developmental Biology Institute of Marseille Luminy, 13288 Marseille, France
Genetics 174:1625-34. 2006The larval development of the Drosophila melanogaster wings is organized by the protein Wingless, which is secreted by cells adjacent to the dorsal-ventral (DV) boundary...
- CNS midline to mesoderm signaling in DrosophilaL Zhou
Program for Neuroscience and Behavior, University of Massachusetts at Amherst, 01003, USA
Mech Dev 67:59-68. 1997The dorsal median cells are unique mesodermal cells that reside on the surface of the ventral nerve cord in the Drosophila embryo...
- The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryoErica Moran
Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, Barcelona 08028, Spain
Mol Cell Biol 26:3446-54. 2006Tailless is an orphan nuclear receptor that controls terminal body patterning in Drosophila. Genetic analyses have revealed both positive and negative regulatory interactions of Tailless with various target genes, leading to the idea that,..
- In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elementsLeonie U Hempel
Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Strasse 8, 35043 Marburg, Germany
Dev Dyn 235:1053-64. 2006..Translational repression elements for both mRNAs are localized in the 5' UTR and are capable to form distinct secondary structures in close proximity to the translational initiation codon...
- Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midlineDavid S Garbe
Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
Development 134:4325-34. 2007..Here, we demonstrate that Drosophila fra mutant embryos exhibit guidance defects in a specific subset of commissural axons and these defects can be ..
- Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in DrosophilaAllison J Bardin
CNRS UMR 8542, Ecole Normale Superieure, 46, rue d Ulm, 75230 Paris Cedex, France
Dev Cell 10:245-55. 2006Endocytosis of Notch receptor ligands in signaling cells is essential for Notch receptor activation. In Drosophila, the E3 ubiquitin ligase Neuralized (Neur) promotes the endocytosis and signaling activity of the ligand Delta (Dl)...
- Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbJ Jiang
Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nature 391:493-6. 1998....
- Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responsesR G Wisotzkey
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Development 125:1433-45. 1998Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD-related protein that functions in DPP signaling...
- Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgutM C Steitz
Department of Biology and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
Dev Biol 197:218-33. 1998..Genetic studies of the signaling pathway of the Drosophila Wnt homologue, Wingless, have identified a number of genes, including zeste white 3, which function to transduce ..
- Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eyeJessica Reynolds-Kenneally
Brookdale Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Dev Biol 285:38-48. 2005During Drosophila eye development, localized Notch signaling at the dorsal ventral (DV)-midline promotes growth of the entire eye field...
- DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discsJoogyung Hyun
Department of Biomedical Genetics, The Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
Mol Cell Biol 25:5590-8. 2005..factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila melanogaster...
- GENETIC ANALYSIS OF POLARITYRuth Steward; Fiscal Year: 2009Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010Abstract: The developmental mechanisms of human and Drosophila blood systems show remarkable parallels...
- PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILAKENT GOLIC; Fiscal Year: 2002..The fourth specific aim will aim to adapt for Drosophila the "cassette exchange" method of FLP-mediated DNA integration developed by Schlake and Bode...
- A GENETIC ANALYSIS OF TASTE IN DROSOPHILABeth Gordesky Gold; Fiscal Year: 2007The overall goal of this program is to investigate the genetic basis of taste-guided behavior in Drosophila melanogaster. We are broadly interested in genes that can directly impact complex behaviors...
- Genetic Studies of Optic AtrophyTaosheng Huang; Fiscal Year: 2010..of an effective therapeutic agent for optic atrophies, recently we have generated an Opa1 knockout model in Drosophila. By analyzing phenotypes in the developing and adult Drosophila eyes, we found that the heterozygous mutation of ..
- Regulation of Drosophila arrestins in light adaptationBih Hwa Shieh; Fiscal Year: 2010..modulates arrestin activity to control the output of rhodopsin thereby fine tuning the visual signaling, using Drosophila eye as a model system...
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and invertebrate systems...
- Developmental Regulation of the Cell Cycle in DrosophilaLAURA ANNE LEE; Fiscal Year: 2010..of functional conservation of genes involved in the cell cycle combined with the superb genetics and cytology of Drosophila melanogaster make it an ideal model organism for studying cell-cycle regulation in a developmental context...
- GENETIC DISSECTION OF PHOTOTRANSDUCTIONBaruch Minke; Fiscal Year: 1993..Transgenic Drosophila flies transformed by epitope-tagged and site- directed modified trp gene in a null trp background will be used ..
- REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNINGPaul MacDonald; Fiscal Year: 2003The formation of the embryonic axes is in Drosophila controlled by the localization of determinants in form of mRNAs within the oocyte...
- ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALESMARIANA FEDERICA WOLFNER; Fiscal Year: 2010..Despite their importance, the functions of these proteins are not well understood. We use Drosophila's "Acp" seminal proteins as a model to investigate the mechanisms by which seminal proteins affect females...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2010..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster...
- EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTERMATTHEW WALLENFANG; Fiscal Year: 2007..The research proposed examines the effect of aging on stem cells in the Drosophila testis, which presents 3 major advantages for this type of study...
- Mechanisms of receptor protein tyrosine phosphatase signaling in Drosophila develJessica E Treisman; Fiscal Year: 2010..The fruit fly Drosophila offers an attractive model system in which to address the mechanisms of RPTP function in vivo...
- Aging specific gene expression in DrosophilaJOHN GERARD TOWER; Fiscal Year: 2010..goal of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster...
- Aging specific gene expression in DrosophilaJohn Tower; Fiscal Year: 2009..goal of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster...
- QTLs in DrosophilaTrudy Mackay; Fiscal Year: 2009..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- QTLs in DrosophilaEric A Stone; Fiscal Year: 2010..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- QTLs in DrosophilaTrudy Mackay; Fiscal Year: 2009..b>Drosophila melanogaster is an excellent model system for elucidating general principles regarding the genetic architecture ..
- Translational regulation of cellular morphogenesis in early Drosophila embryosPaul M Macdonald; Fiscal Year: 2010..to elucidate the mRNA translational regulatory mechanisms that control cellular morphogenesis in cleavage stage Drosophila embryos...
- Somatic stem cells in the Drosophila ovaryDANIEL D KALDERON; Fiscal Year: 2010..Most stem cell niches are hard to access or define. The Drosophila ovary, in which germline and somatic stem cell progeny collaborate to produce eggs, provides an exception that ..
- MOLECULAR GENETICS OF PHOTOTRANSDUCTIONBih Hwa Shieh; Fiscal Year: 2000DESCRIPTION: The investigator will use phototransduction in Drosophila as a model system to understand the coordination of the activation and deactivation processes of signal transduction...
- MOLECULAR GENETICS OF AXON GUIDANCE IN THE DROSOPHILAKai Zinn; Fiscal Year: 1993..suitable for cell biology studies, such as the grasshopper, and species with well-developed genetics, such as Drosophila. A variety of data suggest that individual axons or axon bundles in insect segmental ganglia are differentially ..
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010Synaptic target selection in Drosophila Abstract: Genetic screens in Drosophila identified many of the cell-surface and secreted (CSS) proteins that are intensively studied today as regulators of axon guidance in both vertebrate and ..
- Drosophila as a model genetic system to study neuropsychiatric disordersCharles Nichols; Fiscal Year: 2007..hypothesis of our research is that molecular events initiated by agents acting at serotonin receptors in Drosophila, and other animal models, represent potential candidates for involvement in the development and etiology of ..
- HCO3-transporters in Drosophila and MosquitoesMICHAEL ROMERO; Fiscal Year: 2003..Recently we have cloned a Na+-driven anion exchangers (NDAE1) from Drosophila and immunolocalized NDAE1 to epithelia (gut, Malpighian tubules and salivary glands) as well as the central and ..
- Identifying Cardiomyopathy Genes in Mice and DrosophilaHoward Rockman; Fiscal Year: 2007..that the powerful mutagen, N-ethyl-N- nitrosourea (ENU), mutagenesis in mice, and gene-deletion screens in Drosophila, will lead to the discovery of novel disease-causing and disease-modifying genes for human heart failure...
- Identifying Cardiomyopathy Genes in Mice and DrosophilaHoward Rockman; Fiscal Year: 2009..that the powerful mutagen, N-ethyl-N- nitrosourea (ENU), mutagenesis in mice, and gene-deletion screens in Drosophila, will lead to the discovery of novel disease-causing and disease-modifying genes for human heart failure...
- CELLULAR COMMUNICATION IN MORPHOGENESISMark Krasnow; Fiscal Year: 2003This is a proposal to identify and characterize response pathways in Drosophila cells that are triggered by lack of oxygen (hypoxia). During the previous funding period, Dr...