Genomes and Genes
Summary: An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, Sarcophagidae, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).
Publications309 found, 100 shown here
- Episodic radiations in the fly tree of lifeBrian M Wiegmann
Department of Entomology, North Carolina State University, Raleigh, NC 27695, USA
Proc Natl Acad Sci U S A 108:5690-5. 2011..b>Diptera includes species known for their ubiquity (Musca domestica house fly), their role as pests (Anopheles gambiae ..
- DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification successRudolf Meier
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
Syst Biol 55:715-28. 2006..Here, we test two key claims of molecular taxonomy using 1333 mitochondrial COI sequences for 449 species of Diptera. We investigate whether sequences can be used for species identification ("DNA barcoding") and find a relatively ..
- DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)M Alex Smith
Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
Proc Natl Acad Sci U S A 103:3657-62. 2006..as a tool for species identification and discovery for the 20 morphospecies of Belvosia parasitoid flies (Diptera: Tachinidae) that have been reared from caterpillars (Lepidoptera) in Area de Conservación Guanacaste (ACG), ..
- First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from EthiopiaDelenasaw Yewhalaw
Department of Biology, Jimma University, Jimma, Ethiopia
Am J Trop Med Hyg 83:122-5. 2010..of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia...
- Efficiency and ambiguity in an adaptive neural codeA L Fairhall
NEC Research Institute, 4 Independence Way, New Jersey 08540, USA
Nature 412:787-92. 2001..The speed with which information is optimized and ambiguities are resolved approaches the physical limit imposed by statistical sampling and noise...
- The metabolic cost of neural informationS B Laughlin
Department of Zoology, University of Cambridge, UK
Nat Neurosci 1:36-41. 1998..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
- Beyond barcoding: a mitochondrial genomics approach to molecular phylogenetics and diagnostics of blowflies (Diptera: Calliphoridae)Leigh A Nelson
Australian National Insect Collection, CSIRO Ecosystem Sciences, Canberra, ACT, 2601, Australia
Gene 511:131-42. 2012..sericata and allowed us to conclude that it is due to hybrid introgression prior to the last common ancestor of modern sericata populations, rather than due to recent hybridisation, nuclear pseudogenes or incomplete lineage sorting...
- DNA barcodes affirm that 16 species of apparently generalist tropical parasitoid flies (Diptera, Tachinidae) are not all generalistsM Alex Smith
Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
Proc Natl Acad Sci U S A 104:4967-72. 2007....
- Diptera vectors of avian Haemosporidian parasites: untangling parasite life cycles and their taxonomyDiego Santiago-Alarcon
Biología y Conservación de Vertebrados, Instituto de Ecologia, AC, Xalapa, CP, Mexico
Biol Rev Camb Philos Soc 87:928-64. 2012..Herein we review studies conducted on Diptera vectors transmitting avian haemosporidians from the late 1800s to the present...
- Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in DipteraHajime Ono
The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
Dev Biol 298:555-70. 2006..These studies suggest an evolutionary split between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during development.
- Reactive oxygen species are involved in plant defense against a gall midgeXuming Liu
Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA
Plant Physiol 152:985-99. 2010..Overall, our data indicate that class III peroxidases may play a role in ROS generation in resistant wheat and nonhost rice plants during response to Hessian fly attacks...
- Diptera of forensic importance in the Iberian Peninsula: larval identification keyY Velásquez
Departamento de Ciencias Ambientales y Recursos Naturales Instituto Universitario CIBIO, Universidad de Alicante, Alicante, Spain
Med Vet Entomol 24:293-308. 2010A revision of the species and families of sarcosaprophagous flies (Diptera: Calliphoridae, Sarcophagidae, Muscidae, Fanniidae, Drosophilidae, Phoridae, Piophilidae and Stratiomyidae) suitable for forensic purposes in the Iberian ..
- Mitochondrial genome sequences of Nematocera (lower Diptera): evidence of rearrangement following a complete genome duplication in a winter crane flyAndrew T Beckenbach
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Genome Biol Evol 4:89-101. 2012The complete mitochondrial DNA sequences of eight representatives of lower Diptera, suborder Nematocera, along with nearly complete sequences from two other species, are presented...
- Condition dependence of sexual ornament size and variation in the stalk-eyed fly Cyrtodiopsis dalmanni (Diptera: Diopsidae)Samuel Cotton
The Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom
Evolution 58:1038-46. 2004..Thus, evaluation of male eyespan allows females to gain additional information about male condition over and above that given by body size. These findings accord well with condition-dependent handicap models of sexual selection...
- Environmental and biological factors influencing Culex pipiens quinquefasciatus (Diptera: Culicidae) vector competence for West Nile VirusStephanie L Richards
Florida Medical Entomology Laboratory, Department of Entomology and Nematology, University of Florida IFAS, Vero Beach, FL, USA
Am J Trop Med Hyg 83:126-34. 2010..Differences in the environmental (EIT and dose) and biological (mosquito age and colony) effects from previous studies of Cx. p. quinquefasciatus vector competence for St. Louis encephalitis virus are discussed...
- Skipping clues: forensic importance of the family Piophilidae (Diptera)Daniel Martín-Vega
Departamento de Zoología y Antropología Física, Facultad de Ciencias, Universidad de Alcala, Ctra Madrid Barcelona km 33 6, 28871 Alcala de Henares, Madrid, Spain
Forensic Sci Int 212:1-5. 2011Among the insects which are typically considered of forensic interest, the family Piophilidae (Diptera) is frequently cited because of its common occurrence on carcasses in different stages of decay...
- Juvenile hormone mediates a trade-off between primary and secondary sexual traits in stalk-eyed fliesCatherine L Fry
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 8:191-201. 2006..Collectively, these results are consistent with JH-mediated allocation of resources to eye-span at the expense of testes, and indicate potential costs for the production of an exaggerated trait...
- A de novo transcriptome assembly of Lucilia sericata (Diptera: Calliphoridae) with predicted alternative splices, single nucleotide polymorphisms and transcript expression estimatesS H Sze
Department of Computer Science and Engineering, Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
Insect Mol Biol 21:205-21. 2012The blow fly Lucilia sericata (Diptera: Calliphoridae) (Meigen) is a nonmodel organism with no reference genome that is associated with numerous areas of research spanning the ecological, evolutionary, medical, veterinary and forensic ..
- Conservation of capa peptide-induced nitric oxide signalling in DipteraValerie P Pollock
Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
J Exp Biol 207:4135-45. 2004..and cGMP in capa peptide signalling were tested in several other insect species of medical relevance within the Diptera (Aedes aegypti, Anopheles stephensi and Glossina morsitans) and in one orthopteran out-group, Schistocerca ..
- Insect satiety: sulfakinin localization and the effect of drosulfakinin on protein and carbohydrate ingestion in the blow fly, Phormia regina (Diptera: Calliphoridae)K E Downer
Department of Plant, Soil and Insect Sciences, Division of Entomology, University of Massachusetts, Amherst, MA 01003, USA
J Insect Physiol 53:106-12. 2007..The results of this study lend further support to the idea that carbohydrate and protein feeding are regulated by separate control mechanisms, especially in Calliphoridae...
- The evolution of reproductive isolation through sexual conflictOliver Y Martin
Zoological Museum, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Nature 423:979-82. 2003..This result strongly suggests that speciation can occur rapidly in large populations through increased sexual conflict...
- The mitochondrial genome of the primary screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae)A C Lessinger
Laboratório de Genética Animal, Laboratório Genoma, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
Insect Mol Biol 9:521-9. 2000..hominivorax (Calyptratae) and the Acalyptratae in a typical Brachycera cluster. The identification of diagnostic restriction sites on the sequenced mitochondrial genome and the correlation with previous RFLP analysis are discussed...
- Flight activity alters velocity tuning of fly motion-sensitive neuronsSarah Nicola Jung
Department Systems and Computational Neurobiology, Max Planck Institute for Neurobiology, D 82152 Martinsried, Germany
J Neurosci 31:9231-7. 2011..CDM has been previously shown to induce arousal in flies. We found that flying as well as the application of CDM significantly broadens the velocity tuning of H1 toward higher velocities...
- The development and evolution of bristle patterns in DipteraP Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
Development 126:1349-64. 1999The spatial distribution of sensory bristles on the notum of different species of Diptera is compared...
- A new Sodalis lineage from bloodsucking fly Craterina melbae (Diptera, Hippoboscoidea) originated independently of the tsetse flies symbiont Sodalis glossinidiusEva Novakova
Faculty of Biological Sciences and Institute of Parasitology, Ceske Budejovice, Czech Republic
FEMS Microbiol Lett 269:131-5. 2007....
- BMP signaling components in embryonic transcriptomes of the hover fly Episyrphus balteatus (Syrphidae)Steffen Lemke
University of Chicago, Dept, of Organismal Biology and Anatomy, CLSC 921B, 920 E, 58th Street, Chicago, IL 60637, USA
BMC Genomics 12:278. 2011..The closest relatives of D. melanogaster with clearly distinct DV differentiation are hover flies (Diptera: Syrphidae)...
- Sand fly vectors (Diptera, Psychodidae) of American visceral leishmaniasis areas in the Atlantic Forest, State of Espírito Santo, southeastern BrazilIsrael de Souza Pinto
Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, CEP 21040 360, Rio de Janeiro, RJ, Brazil
J Vector Ecol 37:90-6. 2012..Therefore, Evandromyia lenti may be used as an index species for the occurrence of Lutzomyia longipalpis...
- BMP-dependent serosa and amnion specification in the scuttle fly Megaselia abditaAb Matteen Rafiqi
University of Chicago, Department of Organismal Biology and Anatomy, Chicago, IL 60637, USA
Development 139:3373-82. 2012..We propose that changes in the BMP activity profile at the beginning of gastrulation might have contributed to the reduction of extra-embryonic tissue types during the radiation of cyclorrhaphan flies...
- Insect succession and carrion decomposition in selected forests of Central Europe. Part 3: Succession of carrion faunaSzymon Matuszewski
Department of Criminalistics, Adam Mickiewicz University, Sw Marcin 90, 61 809 Poznań, Poland
Forensic Sci Int 207:150-63. 2011..Implications for methods of PMI estimation (particularly the succession-based method) are discussed...
- A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoansW McGinnis
Cell 37:403-8. 1984..Apparently at least a part of these developmental switch genes from Drosophila is highly conserved during evolution, and might perform an analogous function in many metazoans ...
- A preliminary investigation of insect colonisation and succession on remains in New ZealandTerry L Eberhardt
The University of Auckland, Department of Chemistry, Forensic Science Programme, Building 301, Level 5, 23 Symonds St, Auckland, New Zealand
Forensic Sci Int 176:217-23. 2008..This preliminary investigation presents a broad outline of the insects associated with remains and the order in which they appear in the Auckland region...
- Purification and characterization of an antimicrobial peptide, insect defensin, from immunized house fly (Diptera: Muscidae)X L Dang
School of Life Sciences, Sun Yat Sen University, Guangzhou, China
J Med Entomol 47:1141-5. 2010The house fly, Musca domestica L. (Diptera: Muscidae), is involved in phoretic movement of pathogenic agents, but it has a very efficient defense mechanism against infection...
- Spatial and temporal variability of necrophagous Diptera from urban to rural areasC Hwang
Department of Life Sciences, King s College London, UK
Med Vet Entomol 19:379-91. 2005..Correspondence analysis showed clearly seasonal patterns at Box Hill site. The species-habitat associations suggest habitat differentiation between necrophagous guilds in this area and may be of ecological value...
- Molecular phylogenetics of the holly leafminers (Diptera: Agromyzidae: Phytomyza): species limits, speciation, and dietary specializationS J Scheffer
Systematic Entomology Laboratory, USDA, Agricultural Research Service, Beltsville, Maryland 20705, USA
Mol Phylogenet Evol 17:244-55. 2000..Monophagy is the most common feeding pattern in holly leafminers, and more generalized feeding is inferred to have evolved at least two separate times, possibly as a prelude to speciation...
- Simplified media for spiroplasmas associated with tabanid fliesRebekah W Moulder
Department of Biology, Georgia Southern University, Statesboro 30460 8042, USA
Can J Microbiol 48:1-6. 2002..and deer flies (Chrysops spp.) (Diptera: Tabanidae) have been accomplished in the complex M1D medium...
- Detection of Cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibodyThaddeus K Graczyk
The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Trop Med Hyg 68:228-32. 2003....
- Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher DipteraC Wülbeck
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 127:1411-20. 2000..Other species of derived schizophoran Diptera have equally stereotyped, but different, bristle patterns...
- MyiasisFabio Francesconi
Dermatology Section, Universidade Federal do Amazonas, Brazil
Clin Microbiol Rev 25:79-105. 2012..In this review, we deeply discuss myiasis as a worldwide infestation with different agents and with its broad scenario of clinical manifestations as well as diagnosis techniques and treatment...
- Bartonella species in bat flies (Diptera: Nycteribiidae) from western AfricaS A Billeter
Centers for Disease Control and Prevention, Division of Vector Borne Diseases, Fort Collins, Colorado, USA
Parasitology 139:324-9. 2012..A survey was conducted to identify whether Cyclopodia greefi greefi (Diptera: Nycteribiidae) collected from Ghana and 2 islands in the Gulf of Guinea harbour Bartonella...
- Conservation and sex-specific splicing of the doublesex gene in the economically important pest species Lucilia cuprinaCarolina Concha
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
J Genet 89:279-85. 2010..This intron/exon arrangement had previously been found only in the housefly dsx gene, suggesting this may be a unique feature of dsx genes of Calyptratae species...
- Virulence analysis of Hessian fly populations from Texas, Oklahoma, and KansasMing Shun Chen
Plant Science and Entomology Research Unit, Grain Marketing and Production Research Center, USDA ARS, 1515 College Ave, Manhattan, KS 66506, USA
J Econ Entomol 102:774-80. 2009..97) with the percentages of susceptible plants in a virulence test. This suggests that virulence assays, which require less time and effort, can be used to approximate biotype composition...
- Maternal and paternal condition effects on offspring phenotype in Telostylinus angusticollis (Diptera: Neriidae)R Bonduriansky
Evolution and Ecology Research Centre, and School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia
J Evol Biol 20:2379-88. 2007..In such species, the transfer of paternal condition to offspring could contribute to indirect selection on female mate preferences...
- Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservationEmily E Hare
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
PLoS Genet 4:e1000106. 2008..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
- Placement of Conopidae (Diptera) within Schizophora based on mtDNA and nrDNA gene regionsJoel F Gibson
Agriculture and Agri Food Canada, Canadian National Collection of Insects, Arachnids and Nematodes, Ottawa, Ontario, Canada
Mol Phylogenet Evol 56:91-103. 2010..using molecular characters, as well as the largest molecular analysis of relationships within Schizophora (Diptera) to date, is presented...
- Variability in spike trains during constant and dynamic stimulationA K Warzecha
Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501 Bielefeld, Germany
Science 283:1927-30. 1999..For large parts of the neuron's activity range, the variability of the responses was very similar for constant and time-varying stimuli and was considerably smaller than that in many visual interneurons of vertebrates...
- A comparative analysis of the evolution of imperfect mimicryHeather D Penney
Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, K1S 5B6, Canada
Nature 483:461-4. 2012..For example, many hoverflies (Diptera: Syrphidae) are harmless (Batesian) mimics of stinging Hymenoptera...
- Serine proteinase inhibitors in arthropod immunityM R Kanost
Department of Biochemistry, Kansas State University, Manhattan 66506, USA
Dev Comp Immunol 23:291-301. 1999..Some may inhibit fungal or bacterial proteinases. Others probably have roles in regulating endogenous proteinases involved in coagulation, prophenol oxidase activation, or cytokine activation...
- The mitochondrial genome of the mediterranean fruit fly, Ceratitis capitataL Spanos
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Crete, Greece
Insect Mol Biol 9:139-44. 2000..Moreover, they could help obtain a solution to the long-lasting controversy on the possible eradication of the Medfly from certain locations...
- The tropical African latrine blowfly, Chrysomya putoria (Wiedemann)B R Laurence
London School of Hygiene and Tropical Medicine
Med Vet Entomol 2:285-91. 1988..chloropyga (Wiedemann, 1818) (Diptera: Calliphoridae). The biology of C...
- The phylogeny and evolution of host choice in the Hippoboscoidea (Diptera) as reconstructed using four molecular markersFrederik Torp Petersen
Zoological Museum, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen Ø, Denmark
Mol Phylogenet Evol 45:111-22. 2007Hippoboscoidea is a superfamily of Diptera that contains the Glossinidae or tsetse flies, the Hippoboscidae or louse flies, and two families of bat flies, the Streblidae and the Nycteribiidae...
- Transfer of visual motion information via graded synapses operates linearly in the natural activity rangeR Kurtz
Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501 Bielefeld, Germany
J Neurosci 21:6957-66. 2001..Thus, the inevitably limited range in which the gain of overall synaptic signal transfer is constant appears to be adjusted to sensory input strengths...
- Central gating of fly optomotor responseJuergen Haag
Department of Systems and Computational Neurobiology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 107:20104-9. 2010..While head movements of flies have only a small amplitude when flies are at rest, the response amplitude is increased by a factor of 30-40 during flight...
- Larvae of related Diptera species from thermally contrasting habitats exhibit continuous up-regulation of heat shock proteins and high thermotoleranceDavid G Garbuz
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, 119991 Moscow, Russia
Mol Ecol 17:4763-77. 2008A population of Stratiomys japonica, a species belonging to the family Stratiomyidae (Diptera), common name 'soldier flies', occurs in a hot volcanic spring, which is apparently among the most inhospitable environments for animals ..
- Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolutionSimon L Bullock
Cancer Research UK, Developmental Genetics Laboratory, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 131:4251-61. 2004..We find that although localisation of wingless transcripts is conserved in Diptera, localisation of even-skipped and hairy pair-rule transcripts is evolutionarily labile and correlates with taxon-..
- Against all odds: explaining high host specificity in dispersal-prone parasitesCarl W Dick
Department of Zoology, Field Museum of Natural History, Chicago, IL 60605 2496, USA
Int J Parasitol 37:871-6. 2007....
- The geographical mosaic of coevolution in a plant-pollinator mutualismBruce Anderson
School of Biological and Conservation Sciences, University of KwaZulu Natal, P Bag X01, Scottsville, Pietermaritzburg, South Africa
Evolution 62:220-5. 2008..We conclude that coevolution is a compelling explanation for the geographical covariation in flower depth and fly proboscis length...
- Encoding of naturalistic optic flow by a population of blowfly motion-sensitive neuronsK Karmeier
Department of Neurobiology, Faculty for Biology, Bielefeld University, Bielefeld, Germany
J Neurophysiol 96:1602-14. 2006....
- Male sexual ornament size is positively associated with reproductive morphology and enhanced fertility in the stalk-eyed fly Teleopsis dalmanniDavid W Rogers
The Galton Laboratory, Research Department of Genetics, Evolution and Environment, University College London, 4 Stephenson Way, London, NW1 2HE, UK
BMC Evol Biol 8:236. 2008..Here we investigate whether male eyespan indicates accessory gland and testis length, and then ask whether mating with large eyespan males affects female fertility...
- Factors affecting decomposition and Diptera colonizationC P Campobasso
Section of Legal Medicine (DI.M.I.M.P, University of Bari, Piazza Giulio Cesare, 70100 Policlinico-Bari, Italy
Forensic Sci Int 120:18-27. 2001..On account of their activity and world wide distribution, Diptera are the insects of greatest forensic interest...
- Phylogenetic relationships among fruit flies, Bactrocera (Diptera, Tephritidae), based on the mitochondrial rDNA sequencesM Muraji
National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
Insect Mol Biol 10:549-59. 2001..The results are discussed in relation to the taxonomic positions of species used in this study and in relation to the phylogenetic and diagnostic utility of the mitochondrial rDNA fragment...
- Nonlinear, binocular interactions underlying flow field selectivity of a motion-sensitive neuronKarl Farrow
Max Planck Institute of Neurobiology, Department of Systems and Computational Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
Nat Neurosci 9:1312-20. 2006..This is accomplished through a modulation of H2's membrane potential by input from the contralateral HSE cell, which scales the firing rate of H2 during visual stimulation but is not sufficient to induce action potentials...
- On the computations analyzing natural optic flow: quantitative model analysis of the blowfly motion vision pathwayJ P Lindemann
Department of Neurobiology, Faculty for Biology, Bielefeld University, D 33501 Bielefeld, Germany
J Neurosci 25:6435-48. 2005....
- Functional characterization of HFR1, a high-mannose N-glycan-specific wheat lectin induced by Hessian fly larvaeSubhashree Subramanyam
Department of Agronomy, Purdue University, West Lafayette, Indiana 47907, USA
Plant Physiol 147:1412-26. 2008..Thus, HFR1 is an antinutrient to dipteran larvae and may play a significant role in deterring Hessian fly larvae from feeding on resistant wheat plants...
- Adaptation of response transients in fly motion vision. II: Model studiesAlexander Borst
Department of Systems and Computational Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152, Martinsried, Germany
Vision Res 43:1309-22. 2003..Moreover, such an elaborated model with an adaptive time-constant faithfully mimics a particular contrast-dependency of transient response oscillations observed in fly motion sensitive neurons...
- Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glandsXueqing Xu
Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Mol Cell Proteomics 7:582-90. 2008..of the host, were identified and characterized from 30,000 pairs salivary glands of the horsefly Tabanus yao (Diptera, Tabanidae)...
- The transformer gene in Ceratitis capitata provides a genetic basis for selecting and remembering the sexual fateAttilio Pane
Dipartimento di Genetica, Biologia Generale e Molecolare, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
Development 129:3715-25. 2002..The male pathway seems to result when Cctra autoregulation is prevented and instead splice variants with truncated open reading frames are produced. We propose that this repression is achieved by the Y-linked male-determining factor (M)...
- Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh flyGregory J Ragland
Department of Entomology and Nemtaology, University of Florida, Gainesville, FL 32611 0620, USA
Proc Natl Acad Sci U S A 107:14909-14. 2010....
- Mechanical transmission of human protozoan parasites by insectsThaddeus K Graczyk
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Clin Microbiol Rev 18:128-32. 2005..Mechanical transmission of human parasites by nonbiting flies and epidemiological involvement of other synanthropic insects in human food-borne diseases have not received adequate scientific attention...
- Recurrent network interactions underlying flow-field selectivity of visual interneuronsJ Haag
Division of Insect Biology, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720-3112, USA
J Neurosci 21:5685-92. 2001..In addition to feedforward connectivity, thus, the flow-field selectivity of LPTCs may be significantly attributable to recurrent excitation involving the network of large-field neurons in both brain hemispheres...
- Response latency of a motion-sensitive neuron in the fly visual system: dependence on stimulus parameters and physiological conditionsA Warzecha
Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501, Bielefeld, Germany
Vision Res 40:2973-83. 2000..Since response latencies cover a range of one order of magnitude, the latency changes are expected to be of relevance in visually guided orientation behaviour...
- Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativaLi Hua Huang
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, B5 Datun Road, Chaoyang District, Beijing 100101, China
J Insect Physiol 55:279-85. 2009..These results suggest that, in addition to a heat shock response, these HSPs may be involved in the development of L. sativae...
- The black soldier-fly, Hermetia illucens (Diptera, Stratiomyidae), used to estimate the postmortem interval in a case in Amapá State, BrazilJosé R Pujol-Luz
Departamento de Zoologia and Núcleo de Entomologia Urbana e Forense, Universidade de Brasilia, Brasilia, DF, Brazil
J Forensic Sci 53:476-8. 2008..Since H. illucens usually (but not always) colonizes corpses in more advanced stages of decay, this estimate is consistent with the hypothesis that the child was killed immediately after abduction...
- Reductive genome evolution, host-symbiont co-speciation and uterine transmission of endosymbiotic bacteria in bat fliesTakahiro Hosokawa
National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
ISME J 6:577-87. 2012..The designation 'Candidatus Aschnera chinzeii' is proposed for the endosymbiont clade...
- The use of COI barcodes for molecular identification of forensically important fly species in GermanyPetra Boehme
Institute of Forensic Medicine, Goethe University Frankfurt, Kennedyallee 104, 60596, Frankfurt am Main, Germany
Parasitol Res 110:2325-32. 2012..oxidase I gene "barcoding region" as a universal marker for molecular identification of forensically important Diptera. We analyzed 111 specimens belonging to 13 species originating from Frankfurt am Main, Germany (Calliphoridae: ..
- The molecular systematics of blowflies and screwworm flies (Diptera: Calliphoridae) using 28S rRNA, COX1 and EF-1α: insights into the evolution of dipteran parasitismLaura M McDonagh
College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX44QD, UK
Parasitology 138:1760-77. 2011..In summary, this study represents the most comprehensive molecular phylogenetic analysis of family Calliphoridae undertaken to date...
- Differential decomposition patterns in charred versus un-charred remainsAriel Gruenthal
School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK
J Forensic Sci 57:12-8. 2012..Body regions displaying significant charring decomposed at a faster rate (p < 0.001), while areas with very light levels of charring decomposed at a significantly slower rate (p < 0.001)...
- Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glandsPeter Takac
Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovak Republic
J Exp Biol 209:343-52. 2006..Here we describe the first evidence of vasodilators in horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary gland extract and clone and express one of the active peptides (termed vasotab)...
- External ophthalmomyiasis by oestrus ovis: an unknown endemic eye disease in rural parts of central IndiaS Misra
Department of Ophthalmology, Rural Medical College, Pravara Medical Trust, Loni 413736, Maharastra, India
Trop Doct 38:120-2. 2008....
- A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous DipteraJoanna Richardson
Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Dev Genes Evol 216:29-38. 2006..This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera and that many differences are likely to be due to changes in cis-regulatory sequences of scute.
- Changing bee and hoverfly pollinator assemblages along an urban-rural gradientAdam J Bates
Geography, Earth and Environmental Sciences, The University of Birmingham, Birmingham, West Midlands, United Kingdom
PLoS ONE 6:e23459. 2011..We assessed changes in the diversity, abundance and species composition of bee and hoverfly pollinator assemblages in urban, suburban, and rural sites across a UK city...
- The utility of mitochondrial DNA sequences for the identification of forensically important blowflies (Diptera: Calliphoridae) in southeastern AustraliaJ F Wallman
Department of Environmental Biology, The University of Adelaide, Adelaide, 5005 SA, Australia
Forensic Sci Int 120:60-7. 2001....
- Chrysomya putoria, a putative vector of diarrheal diseasesSteven W Lindsay
School of Biological and Biomedical Sciences, Durham University, Durham City, United Kingdom
PLoS Negl Trop Dis 6:e1895. 2012..Because of their strong association with human feces and their synanthropic nature, we examined whether these flies are likely to be vectors of diarrheal pathogens...
- An initial study on the succession of sarcosaprophagous Diptera (Insecta) on carrion in the southeastern Iberian peninsulaI Arnaldos
Department of Animal Biology (Zoology, Faculty of Biology, University of Murcia, Spain
Int J Legal Med 114:156-62. 2001We present the results of the first study concerning Diptera carried out on the sarcosaprophagous fauna of southeastern Spain...
- The key mimetic features of hoverflies through avian eyesRoderick S Bain
Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
Proc Biol Sci 274:1949-54. 2007....
- External morphology of Chrysomya pinguis (Walker) (Diptera: Calliphoridae) revealed by scanning electron microscopyKom Sukontason
Department of Parasitology, Chiang Mai University, Chiang Mai 50200, Thailand
Micron 39:190-7. 2008..pinguis that was revealed in this study allows us to know such types of structures in much better detail and may eventually provide a basis for understanding some of the biological behavior of this fly species in the future...
- Human and livestock migrations: a history of bot fly biodiversity in the Mediterranean regionDomenico Otranto
Department of Animal Health and Welfare of the Faculty of Veterinary Medicine, University of Bari, PO Box 7, 70010 Valenzano Bari, Italy
Trends Parasitol 22:209-13. 2006..The movement of animals and their associated parasites in this region can help to explain the evolution of parasitic biodiversity...
- Molecular phylogeny of Calyptratae (Diptera: Brachycera): the evolution of 18S and 16S ribosomal rDNAs in higher dipterans and their use in phylogenetic inferenceX Nirmala
Institute of Parasitology, Academy of Sciences of the Czech Republic,
Insect Mol Biol 10:475-85. 2001..and Antipoda sp., display a tendency to cluster within Oestroidea. The comparison of secondary structures of two variable regions indicates that Sarcophagidae are related to Calliphoridae rather than to Tachinidae...
- Use of cytochrome c oxidase subunit i (COI) nucleotide sequences for identification of the Korean Luciliinae fly species (Diptera: Calliphoridae) in forensic investigationsSeong Hwan Park
Department of Legal Medicine, Colloge of Medicine, Korea University, Seoul, Korea
J Korean Med Sci 24:1058-63. 2009..The results suggest that more individuals from various geographic regions and additive nuclear DNA markers should be analyzed, and morphologic identification keys must be reconfirmed to overcome these inconsistencies...
- Insect succession and decomposition patterns on shaded and sunlit carrion in Saskatchewan in three different seasonsBarbara J Sharanowski
University of Kentucky, Department of Entomology, S 225 Agricultural Science Center North, Lexington, KY 40546 0091, USA
Forensic Sci Int 179:219-40. 2008..Members of Silphidae were the first coleopteran colonizers in all habitats and seasons. This paper also marks the first record for Cochliomyia macellaria (Fabricius) in Saskatchewan...
- DNA-based identification of forensically important Australian Sarcophagidae (Diptera)Kelly A Meiklejohn
Institute for Conservation Biology and Environment Management, School of Biological Sciences, University of Wollongong, NSW 2522, Australia
Int J Legal Med 125:27-32. 2011The utility of the forensically important Sarcophagidae (Diptera) for time since death estimates has been severely limited, as morphological identification is difficult and thermobiological histories are inadequately documented...
- Differential divergences of obligately insect-pathogenic Entomophthora species from fly and aphid hostsAnnette Bruun Jensen
Department of Agriculture and Ecology, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C, Denmark
FEMS Microbiol Lett 300:180-7. 2009..rRNA and GPD) of isolates from the insect-pathogenic fungus genus Entomophthora originating from different fly (Diptera) and aphid (Hemiptera) host taxa were sequenced...
- External ophthalmomyiasis caused by Oestrus ovis: a rare case report from IndiaAnita Pandey
Department of Microbiology, Subharti Medical College, Meerut, Uttar Pradesh, India
Korean J Parasitol 47:57-9. 2009..A 25-year-old farmer presented with severe symptoms of conjunctivitis. The larvae, 3 in number, were observed in the bulbar conjunctiva, and following removal the symptoms of eye inflammation improved within a few hours...
- Identifying fly puparia by clearing technique: application to forensic entomologyKabkaew L Sukontason
Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand
Parasitol Res 101:1407-16. 2007..This provides a key to identifying the puparia of these seven fly species...
- Identification of forensically important Chrysomya (Diptera: Calliphoridae) species using the second ribosomal internal transcribed spacer (ITS2)Leigh A Nelson
Centre for Medical Bioscience, School of Biological Sciences, University of Wollongong, New South Wales 2522, Australia
Forensic Sci Int 177:238-47. 2008The identification of forensically important blowflies of the genus Chrysomya (Diptera: Calliphoridae) may be hampered by their close morphological similarities, especially as immatures...
- Human myiasis in New Zealand: imported and indigenously-acquired cases: the species of concern and clinical aspectsJose G B Derraik
Institute of Natural Sciences, Massey University, Auckland, New Zealand
N Z Med J 123:21-38. 2010..A number of Diptera (fly) families present in New Zealand have been associated with cases of human myiasis: Calliphoridae (7 species),..
- Variability of blowfly head optomotor responsesR Rosner
Lehrstuhl für Neurobiologie, Universitat Bielefeld, Bielefeld, Germany
J Exp Biol 212:1170-84. 2009..Nevertheless, we find the halteres to be responsible for one component of head jitter movements. This component may be the inevitable consequence of their function as equilibrium and gaze-stabilising organs...
- Mechanical transmission of lumpy skin disease virus by Aedes aegypti (Diptera: Culicidae)C M Chihota
Institute for Animal Health, Pirbright Laboratory, Woking, UK
Epidemiol Infect 126:317-21. 2001..LSDV has long been suspected to be insect transmitted, but these findings are the first to demonstrate this unequivocally, and they suggest that mosquito species are competent vectors...
- Seasonal patterns of arthropods occurring on sheltered and unsheltered pig carcasses in Buenos Aires Province (Argentina)N Centeno
Centro de Estudios e Investigaciones Programa de Investigaciones en Interacciones Biologicas CEI PIIB, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal, B1876BXD, Buenos Aires, Argentina
Forensic Sci Int 126:63-70. 2002..In the fall, the difference between sheltered and unsheltered carcasses was small (six species on the former and five species on the latter); in spring and summer, the difference was negligible...
- Identifying insects with incomplete DNA barcode libraries, African fruit flies (Diptera: Tephritidae) as a test caseMassimiliano Virgilio
Royal Museum for Central Africa, Tervuren, Belgium
PLoS ONE 7:e31581. 2012..relationships between identification performances and distance thresholds in four DNA barcode libraries of Diptera (n = 4270), Lepidoptera (n = 7577), Hymenoptera (n = 2067) and Tephritidae (n = 602 DNA barcodes)...
- Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprinaRichard D Newcomb
Gene Technologies Sector, The Horticulture and Food Research Institute of New Zealand, Private Bag 92169 Auckland, New Zealand
J Mol Evol 60:207-20. 2005..Four new sequence haplotypes, not sampled in the survey of extant haplotypes, were obtained that are all associated with susceptibility. This is suggestive of a higher historical level of susceptible allelic diversity at this locus...
- Improving access to the control region and tRNA gene clusters of dipteran mitochondrial DNAM T Oliveira
Laboratório de Genética Animal, Centro de Biologia Molecular e Engenharia Genetica, Departamento de Genetica e Evolucao, Instituto de Biologia, Universidade Estadual de Campinas, CP 6010, CEP 13083 875, Campinas, Sao Paulo, Brazil
J Med Entomol 43:636-9. 2006..These new primers were useful for investigating the nucleotide information and the structural organization of dipteran mtDNA...
- Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic DisPATRICIA MASCARELLI; Fiscal Year: 2011..abstract_text> ..
- REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASESMelanie H Cobb; Fiscal Year: 2012..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
- Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporteAYLIN RACHEL RODAN; Fiscal Year: 2013..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
- Sirtuin/FOXO Signaling in the Regulation of Bone MassStavroula Kousteni; Fiscal Year: 2012..An interaction between this pathway and 2-catenin may enhance FOXO1-mediated transcription and regulate the anti-osteoclastogenic properties of 2-catenin. ..
- Genetic Studies of Optic AtrophyTaosheng Huang; Fiscal Year: 2012..This study will allow us to understand how mutations of OPA1 cause optic atrophy and explore its novel function in lifespan and provide us a potential opportunity to develop treatments for the disease. ..
- Ceramide Metabolism and Photoreceptor HomeostasisUsha R Acharya; Fiscal Year: 2013....
- Roles of RNA Polymerases IV and V in siRNA-mediated gene silencingCRAIG STUART PIKAARD; Fiscal Year: 2013..Our studies of RNA polymerases IV and V are significant with respect to all of these areas, especially the roles of intergenic noncoding RNAs and siRNAs in chromatin-mediated gene silencing. ..
- Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseasHANS BUELER; Fiscal Year: 2010..abstract_text> ..
- Transposons in Female Reproductive Health and DiseaseZev Williams; Fiscal Year: 2013..The purpose of this study is to determine how the oocyte suppresses transposons and the effect of transposons on female reproduction. ..
- Role of surface proteins in sand fly colonization by Bartonella bacilliformisMichael F Minnick; Fiscal Year: 2013..The results of the study are expected to provide a solid foundation for eventually developing control strategies designed to interrupt the sand fly-Bb association. ..
- Tunable Insulin Resistance in a Drosophila Model of DiabetesELENA M GRACHEVA; Fiscal Year: 2010....
- TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTSJeffrey A Simon; Fiscal Year: 2012..This research will advance basic understanding of gene regulatory mechanisms and provide knowledge that could impact stem cell applications in medicine and development of anti-cancer strategies. ..
- AAA ATPases linking mitochondria with microtubule processing in flies and yeastKaren G Hales; Fiscal Year: 2012..These efforts may provide a deeper understanding of mitochondria-related disorders and set the stage for the design of treatments. ..
- Molecular Genetics of Caloric Restriction in Aging FliesBlanka Rogina; Fiscal Year: 2013..It will reveal how reduced caloric intake affects metabolism and life span, and provide the foundation for the development of new therapies for the treatments of age-associated diseases in humans. ..
- Analyzing Anthrax Toxins in DrosophiliaEthan Bier; Fiscal Year: 2013....
- Molecular Physiology of the Epitrachael Endocrine SystemMichael E Adams; Fiscal Year: 2012..Results of these studies also may provide basic new information about vector-borne human diseases involving mosquitoes, flies, ticks, and other arthropods. ..
- Genome-wide Identification of Immediate Early Genes in InsectsAnandasankar Ray; Fiscal Year: 2012....
- Akt, cellular senescence, and lifespanNissim Hay; Fiscal Year: 2010..abstract_text> ..
- The Regulation of Mitochondrial Function by SIRT3Qiang Tong; Fiscal Year: 2010..3) To characterize the effect of SIRT3 on mitochondrial superoxide production and hyperglycemia-induced oxidative stress. 4) To investigate the effect of SIRT3 on adipose oxidative stress during obesity and diabetes in vivo. ..
- Role of FUS in ALSHaining Zhu; Fiscal Year: 2013..The findings are expected to provide critical insights into the mechanisms by which FUS mutations perturb the RNA processing pathways and ultimately lead to the disease. ..
- Mechanisms of Lipid-Induced Hepatic Insulin ResistanceGerald I Shulman; Fiscal Year: 2013....
- Roles for Global Chromatin Structure in C. elegans LongevitySiu Sylvia Lee; Fiscal Year: 2010..Our proposed research may lead to future therapeutic development that aims to improve healthy aging and alleviate age-dependent diseases. ..
- Regulation of TRP channels and visual transductionCraig Montell; Fiscal Year: 2013..Given that the molecular mechanisms underlying the activation of these human TRPs are poorly understood, Drosophila TRP provides an in vivo model for defining the mechanisms regulating TRP channels. ..
- How do Amine Neurons Work?Edward A Kravitz; Fiscal Year: 2013..Studies at these levels of detail are not possible in other species at the present time. ..
- Genetic and Molecular Studies of Drosophila Chromatin Remodeling FactorsJohn W Tamkun; Fiscal Year: 2013..The information gained from this project will therefore be directly relevant to human health. ..
- Using Drosophila as a model to understand TDP-43 function in ALSDavid B Morton; Fiscal Year: 2012....
- A novel and powerful C. elegans behavioral model of addictionEric A Engleman; Fiscal Year: 2013..With the prospect of identifying new molecular targets, and the future application of this model to screen compounds for medications development, this project has a tremendous potential impact for the treatment of human drug addiction. ..
- Genetic control of quantitative traits associated with the metabolic syndromeMaria De Luca; Fiscal Year: 2013..Using this information, human population-based association studies will be performed to investigate the effect of natural variation in the identified regulatory genes on quantitative traits associated with the metabolic syndrome. ..
- Lipid metabolism during tsetse reproductionJOSH B BENOIT; Fiscal Year: 2013..This project will provide avenues to develop proficiency in multiple molecular and physiological techniques that will provide the groundwork for the candidate to become an authority on the molecular physiology of disease vectors. ..
- Oocyte-derived R-spondin2 as a Follicle Stimulating HormoneAARON JW HSUEH; Fiscal Year: 2013..This will be followed by the derivation of healthy pups as the basis for future clinical application using R-spondin2 to treat infertile patients with low FSH responses. ..
- Role of Cofilin and Wnt Signaling in Neural Crest DevelopmentO apos NEIL WIGGAN; Fiscal Year: 2013..abstract_text> ..
- The Molecular Genetics of Early NeurogenesisEthan Bier; Fiscal Year: 2013..e., BMPs repress CRM activity). We will follow a similar strategy to identify and characterize CRMs driving expression of laterally (Pax6) and ventrally (Nkx2.2.) genes. ..
- P. papatasi midgut molecules: gene function and assessing TBV candidatesJOSE MARCELO contact RAMALHO ORTIGAO; Fiscal Year: 2010....
- Centrosomin and Centrosomes in Cell DivisionTimothy L Megraw; Fiscal Year: 2012....
- De novo establishment of Polycomb-group-mediated repressionRichard S Jones; Fiscal Year: 2010....
- Pathophysiology and potential therapy for a childhood neurodegenerative diseaseMarquis T Walker; Fiscal Year: 2011..This proposed work is relevant to the understanding and treatment of MLIV, and to improving the lives of MLIV patients. ..
- 2011 Cell-Cell Fusion Gordon Research Conference and SeminarNANCY RYAN GRAY; Fiscal Year: 2011....
- Tsetse Fecundity Reduction for Trypanosomiasis ControlSerap Aksoy; Fiscal Year: 2013..These elements stand to provide targets for tsetse specific vector control strategies for use in the prevention of trypanosomiasis. ..
- Novel histone biotinylation sites and relationships to other epigenetic marksJANOS contact ZEMPLENI; Fiscal Year: 2010..Previous studies suggest that biotinylation of histones plays a critical role in the repression of retrotransposons, thereby decreasing the incidence of retrotranspositions, chromosomal abnormalities, and probably cancer risk. ..
- Fine-Tuning the Notch Signaling Pathway via O-GlucosylationHamed Jafar-Nejad; Fiscal Year: 2013..In this proposal we will characterize how addition of glucose residues to the Notch protein fine-tunes signaling mediated by this important pathway. ..
- Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and FliesPETER H SPORN; Fiscal Year: 2013..The results should lay the basis for future studies aimed at preventing hypercapnic immune suppression in patients with advanced lung disease. ..
- Generation of Wunen/LPP3-based therapy for muscular dystrophyHannele Ruohola Baker; Fiscal Year: 2010..Ultimately, in the future we wish to test whether manipulating sphingolipid metabolism can serve therapeutic function in muscular dystrophy treatment. ..
- Physiology of Class III PI 3-kinase Signaling 2Jonathan M Backer; Fiscal Year: 2013..Given that hVps34 is one of the key kinases involved in autophagy, a better understanding of its regulation will lead to new insights into this critical cellular process. ..
- GLYCOSYLATION MUTANTS OF LEISHMANIASalvatore J Turco; Fiscal Year: 2012..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
- Mechanisms of glucosensation mediating food choice behavior in DrosophilaMonica Dus; Fiscal Year: 2013..They will also provide mammalian researchers with conserved genes to use as molecular and neurochemical markers in future studies of glucosensation, feeding, and disease. ..
- Genetic and Molecular Mechanisms of Ethanol-Induced Developmental DefectsRACHAEL LOUISE FRENCH; Fiscal Year: 2013....
- 2011 Cold Spring Harbor Conference on Telomeres and TelomeraseDavid J Stewart; Fiscal Year: 2010..The 2011 meeting will result in vigorous discussion and synergistic interactions stimulated by the presentation of a large body of unpublished data. ..
- Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010..Studies of Drosophila as model arthropods may provide insight into persistence of V. cholerae in the environment and suggest ways to prevent or limit pandemic disease. ..
- Sestrin1-knockout mice as a model of facilitated muscle agingJun Hee Lee; Fiscal Year: 2013..As Sesn1 is generally downregulated during muscle pathology in humans, supplementing Sesn1 activity through viral or pharmacological means may offer innovative rejuvenation methods for degenerating muscle in elderly population. ..
- Aging specific gene expression in DrosophilaJOHN GERARD TOWER; Fiscal Year: 2013..By studying gene expression in aging Drosophila, we hope to better understand the basic mechanisms of aging, and to ultimately develop interventions for human aging-related diseases. ..
- Octopamine Neuroanatomy and Functioning in Fruit Fly Social BehaviorKYLE LYNN GOBROGGE; Fiscal Year: 2013..This research program represents first steps in elaborating the neural circuitry underlying social behavior in fruit flies. ..
- Meiotic spindle formation in Drosophila femalesKim S McKim; Fiscal Year: 2010..The objective of these studies is to understand how these errors occur. ..
- Steroid-Dependent Changes in the Yorkie InteractomeAlexey Veraksa; Fiscal Year: 2013..In the second aim, we will use the diverse array of genetic tools in Drosophila to assess the role of individual YNI proteins (identified in the AP- MS experiments) in controlling Yki activity in developing tissues. ..
- Hormonal Modulation of Aggression in DrosophilaEdward A Kravitz; Fiscal Year: 2013..Studies exploring the roles of amine neurons in behavior at this level of detail just are not possible with other model systems at the present time. ..
- Interplay between the Endocrine and Innate Systems of DrosphilaNeal Silverman; Fiscal Year: 2013..In Aim 3, we will test a novel alternative hypothesis that steroid-regulated immune signaling and antimicrobial peptides (AMPs) production facilitate developmental cell death. ..
- Redefining Human Myocardial BiologyAnnarosa Leri; Fiscal Year: 2013..Stem cell therapy may be prospected as a novel therapeutic strategy for the failing heart. ..
- Molecular Basis of Noonan Syndrome and Related DisorderBruce D Gelb; Fiscal Year: 2013..Successful drugs and compounds would likely be useful for most of the RASopathies and for other important clinical aspects such as developmental delays. ..
- Drosophila feeding behavior: New tools for the genetic dissection of prandiologyWilliam W Ja; Fiscal Year: 2012..These discoveries are vital to the development of new therapeutics as well as preventative measures for obesity and other diseases. ..
- Role of Chromatin in Genomic MaintenanceDavid A Sinclair; Fiscal Year: 2012....
- Genetic Analysis of Ataxia-telangiectasiaDAVID WASSARMAN; Fiscal Year: 2012..We have established a Drosophila A-T model that mimics features of neurodegeneration in A-T patients. Using this model we propose to identify gene targets for therapeutic approaches that protect neurons from degeneration in A-T. ..
- Nuclear mechanics and mechanotransduction in muscular laminopathiesJan Lammerding; Fiscal Year: 2013....
- Investigations of the role of house flies as vectors for bacterial pathogensDana Nayduch; Fiscal Year: 2009..expression repertoire that was tailored to each species of bacteria tested, and has not been described in other diptera. The proposed study will further examine the spatial (tissue specific) and temporal expression of these molecules ..
- The role of sand fly saliva in visceralization of Leishmania parasitesGregory Lanzaro; Fiscal Year: 2009..Finally, in Aim #3, we will evaluate the immunomodulatory properties of maxadilan variants found in natural populations of Lu. longipalpis from Brazil and Costa Rica. ..
- Leishmania major nucleoside hydrolase inhibitorsClaude Selitrennikoff; Fiscal Year: 2007..We expect that our work will lead to new compounds with a specific and known mechanism of action that will be useful for the treatment of human leishmaniasis. [unreadable] [unreadable] [unreadable]..
- BLACK FLY IMMUNITY TO ONCHOCERCA SPPEDDIE CUPP; Fiscal Year: 1993..The latter will be evaluated for possible "activation" by filarial antigen and blastogenic response. Changes in hemolymph proteins between uninfected and infected flies will be compared using SDS-PAGE...
- Nucleoside hydrolase Inhibitors from natural products for LeishmaniaESTEBAN EDWARD MENA; Fiscal Year: 2010..Also, there is a concern that leishmaniasis could become more widespread in the United States. Our goal is to identify compounds that can be developed for the effective treatment of Leishmaniasis. ..
- Establishing Drosophila as a Model to Study Hutchinson-Gilford Progeria SyndromeSandra Schulze; Fiscal Year: 2009..But it is also very probable that unraveling the biology of this unusual disease will go some way to explaining the root causes of aging in general, a genetic disease which affects us all. ..
- A novel vaccine against LeishmaniaClaude Selitrennikoff; Fiscal Year: 2005..We believe that this work will lead to the development of prophylactic and therapeutic vaccines against Leishmania ..
- New drugs for the treatment of leishmaniasisClaude Selitrennikoff; Fiscal Year: 2004..Ultimately, this work will lead to the identification of a lead compound for human clinical trials for the treatment of leishmaniasis. ..
- GENETICS AND BIOGEOGRAPHY OF SANDFLY DISEASE VECTORSLeonard Munstermann; Fiscal Year: 2000..The objective of this project is to continue the study of the genetics and biogeography of phlebotomine sand flies (Diptera: Psychodidae)...
- Ecdysone modulation of sexual behavior in Drosophila melanogasterGEOFFREY GANTER; Fiscal Year: 2009..Determination of the mechanisms by which ecdysone controls sexual behavior will result in important clues about the normal function of steroid hormones in controlling the sexual behavior of all animals, including humans. ..
- EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTERMATTHEW WALLENFANG; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- A Drosophila Model for Williams Syndrome Cognitive ProcessingRalph J Greenspan; Fiscal Year: 2010..Accordingly, the study of WS gives us the opportunity to identify, firsthand, genes that influence behavior and cognition. ..
- Clade-specific changes in transcription of olfactory genes in fruit fliesEREZYILMAZ DENIZ; Fiscal Year: 2009..This study will complement those that are restricted to the D. melanogaster model system, and will have implications for the general study of development and neuronal differentiation. ..
- Understanding the Mechanism of RNA Interference (RNAi)Phillip Zamore; Fiscal Year: 2009....
- Meeting:Society for Integrative and Comparative BiologyNeil Blackstone; Fiscal Year: 2004..Ultimately, this work will allow the power of genomics to be fully realized in biology and medicine. ..
- MOLECULAR-GENETIC ANALYSIS OF 3P14 GENOMIC STABILITYHarry Drabkin; Fiscal Year: 2006..Lastly, because wt DTrc8 induces Minute-like phenotypes in adult sensory hairs, the MPN domains of eIF3h and eIF3f will be tested for interactions and further characterized if positive. ..