Summary: An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, Sarcophagidae, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).

Top Publications

  1. pmc Episodic radiations in the fly tree of life
    Brian M Wiegmann
    Department of Entomology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 108:5690-5. 2011
  2. ncbi DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification success
    Rudolf Meier
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
    Syst Biol 55:715-28. 2006
  3. pmc DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 103:3657-62. 2006
  4. pmc First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    Am J Trop Med Hyg 83:122-5. 2010
  5. ncbi Efficiency and ambiguity in an adaptive neural code
    A L Fairhall
    NEC Research Institute, 4 Independence Way, New Jersey 08540, USA
    Nature 412:787-92. 2001
  6. ncbi The metabolic cost of neural information
    S B Laughlin
    Department of Zoology, University of Cambridge, UK
    Nat Neurosci 1:36-41. 1998
  7. ncbi Beyond barcoding: a mitochondrial genomics approach to molecular phylogenetics and diagnostics of blowflies (Diptera: Calliphoridae)
    Leigh A Nelson
    Australian National Insect Collection, CSIRO Ecosystem Sciences, Canberra, ACT, 2601, Australia
    Gene 511:131-42. 2012
  8. pmc DNA barcodes affirm that 16 species of apparently generalist tropical parasitoid flies (Diptera, Tachinidae) are not all generalists
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 104:4967-72. 2007
  9. ncbi Diptera vectors of avian Haemosporidian parasites: untangling parasite life cycles and their taxonomy
    Diego Santiago-Alarcon
    Biología y Conservación de Vertebrados, Instituto de Ecologia, AC, Xalapa, CP, Mexico
    Biol Rev Camb Philos Soc 87:928-64. 2012
  10. ncbi Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera
    Hajime Ono
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 298:555-70. 2006

Detail Information

Publications309 found, 100 shown here

  1. pmc Episodic radiations in the fly tree of life
    Brian M Wiegmann
    Department of Entomology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 108:5690-5. 2011
    ..b>Diptera includes species known for their ubiquity (Musca domestica house fly), their role as pests (Anopheles gambiae ..
  2. ncbi DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification success
    Rudolf Meier
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
    Syst Biol 55:715-28. 2006
    ..Here, we test two key claims of molecular taxonomy using 1333 mitochondrial COI sequences for 449 species of Diptera. We investigate whether sequences can be used for species identification ("DNA barcoding") and find a relatively ..
  3. pmc DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 103:3657-62. 2006
    ..as a tool for species identification and discovery for the 20 morphospecies of Belvosia parasitoid flies (Diptera: Tachinidae) that have been reared from caterpillars (Lepidoptera) in Area de Conservación Guanacaste (ACG), ..
  4. pmc First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    Am J Trop Med Hyg 83:122-5. 2010
    ..of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia...
  5. ncbi Efficiency and ambiguity in an adaptive neural code
    A L Fairhall
    NEC Research Institute, 4 Independence Way, New Jersey 08540, USA
    Nature 412:787-92. 2001
    ..The speed with which information is optimized and ambiguities are resolved approaches the physical limit imposed by statistical sampling and noise...
  6. ncbi The metabolic cost of neural information
    S B Laughlin
    Department of Zoology, University of Cambridge, UK
    Nat Neurosci 1:36-41. 1998
    ..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
  7. ncbi Beyond barcoding: a mitochondrial genomics approach to molecular phylogenetics and diagnostics of blowflies (Diptera: Calliphoridae)
    Leigh A Nelson
    Australian National Insect Collection, CSIRO Ecosystem Sciences, Canberra, ACT, 2601, Australia
    Gene 511:131-42. 2012
    ..sericata and allowed us to conclude that it is due to hybrid introgression prior to the last common ancestor of modern sericata populations, rather than due to recent hybridisation, nuclear pseudogenes or incomplete lineage sorting...
  8. pmc DNA barcodes affirm that 16 species of apparently generalist tropical parasitoid flies (Diptera, Tachinidae) are not all generalists
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 104:4967-72. 2007
  9. ncbi Diptera vectors of avian Haemosporidian parasites: untangling parasite life cycles and their taxonomy
    Diego Santiago-Alarcon
    Biología y Conservación de Vertebrados, Instituto de Ecologia, AC, Xalapa, CP, Mexico
    Biol Rev Camb Philos Soc 87:928-64. 2012
    ..Herein we review studies conducted on Diptera vectors transmitting avian haemosporidians from the late 1800s to the present...
  10. ncbi Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera
    Hajime Ono
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 298:555-70. 2006
    ..These studies suggest an evolutionary split between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during development.
  11. pmc Reactive oxygen species are involved in plant defense against a gall midge
    Xuming Liu
    Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Physiol 152:985-99. 2010
    ..Overall, our data indicate that class III peroxidases may play a role in ROS generation in resistant wheat and nonhost rice plants during response to Hessian fly attacks...
  12. ncbi Diptera of forensic importance in the Iberian Peninsula: larval identification key
    Y Velásquez
    Departamento de Ciencias Ambientales y Recursos Naturales Instituto Universitario CIBIO, Universidad de Alicante, Alicante, Spain
    Med Vet Entomol 24:293-308. 2010
    A revision of the species and families of sarcosaprophagous flies (Diptera: Calliphoridae, Sarcophagidae, Muscidae, Fanniidae, Drosophilidae, Phoridae, Piophilidae and Stratiomyidae) suitable for forensic purposes in the Iberian ..
  13. pmc Mitochondrial genome sequences of Nematocera (lower Diptera): evidence of rearrangement following a complete genome duplication in a winter crane fly
    Andrew T Beckenbach
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Genome Biol Evol 4:89-101. 2012
    The complete mitochondrial DNA sequences of eight representatives of lower Diptera, suborder Nematocera, along with nearly complete sequences from two other species, are presented...
  14. ncbi Condition dependence of sexual ornament size and variation in the stalk-eyed fly Cyrtodiopsis dalmanni (Diptera: Diopsidae)
    Samuel Cotton
    The Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom
    Evolution 58:1038-46. 2004
    ..Thus, evaluation of male eyespan allows females to gain additional information about male condition over and above that given by body size. These findings accord well with condition-dependent handicap models of sexual selection...
  15. pmc Environmental and biological factors influencing Culex pipiens quinquefasciatus (Diptera: Culicidae) vector competence for West Nile Virus
    Stephanie L Richards
    Florida Medical Entomology Laboratory, Department of Entomology and Nematology, University of Florida IFAS, Vero Beach, FL, USA
    Am J Trop Med Hyg 83:126-34. 2010
    ..Differences in the environmental (EIT and dose) and biological (mosquito age and colony) effects from previous studies of Cx. p. quinquefasciatus vector competence for St. Louis encephalitis virus are discussed...
  16. ncbi Skipping clues: forensic importance of the family Piophilidae (Diptera)
    Daniel Martín-Vega
    Departamento de Zoología y Antropología Física, Facultad de Ciencias, Universidad de Alcala, Ctra Madrid Barcelona km 33 6, 28871 Alcala de Henares, Madrid, Spain
    Forensic Sci Int 212:1-5. 2011
    Among the insects which are typically considered of forensic interest, the family Piophilidae (Diptera) is frequently cited because of its common occurrence on carcasses in different stages of decay...
  17. ncbi Juvenile hormone mediates a trade-off between primary and secondary sexual traits in stalk-eyed flies
    Catherine L Fry
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 8:191-201. 2006
    ..Collectively, these results are consistent with JH-mediated allocation of resources to eye-span at the expense of testes, and indicate potential costs for the production of an exaggerated trait...
  18. ncbi A de novo transcriptome assembly of Lucilia sericata (Diptera: Calliphoridae) with predicted alternative splices, single nucleotide polymorphisms and transcript expression estimates
    S H Sze
    Department of Computer Science and Engineering, Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
    Insect Mol Biol 21:205-21. 2012
    The blow fly Lucilia sericata (Diptera: Calliphoridae) (Meigen) is a nonmodel organism with no reference genome that is associated with numerous areas of research spanning the ecological, evolutionary, medical, veterinary and forensic ..
  19. ncbi Conservation of capa peptide-induced nitric oxide signalling in Diptera
    Valerie P Pollock
    Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    J Exp Biol 207:4135-45. 2004
    ..and cGMP in capa peptide signalling were tested in several other insect species of medical relevance within the Diptera (Aedes aegypti, Anopheles stephensi and Glossina morsitans) and in one orthopteran out-group, Schistocerca ..
  20. ncbi Insect satiety: sulfakinin localization and the effect of drosulfakinin on protein and carbohydrate ingestion in the blow fly, Phormia regina (Diptera: Calliphoridae)
    K E Downer
    Department of Plant, Soil and Insect Sciences, Division of Entomology, University of Massachusetts, Amherst, MA 01003, USA
    J Insect Physiol 53:106-12. 2007
    ..The results of this study lend further support to the idea that carbohydrate and protein feeding are regulated by separate control mechanisms, especially in Calliphoridae...
  21. ncbi The evolution of reproductive isolation through sexual conflict
    Oliver Y Martin
    Zoological Museum, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 423:979-82. 2003
    ..This result strongly suggests that speciation can occur rapidly in large populations through increased sexual conflict...
  22. ncbi The mitochondrial genome of the primary screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae)
    A C Lessinger
    Laboratório de Genética Animal, Laboratório Genoma, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Insect Mol Biol 9:521-9. 2000
    ..hominivorax (Calyptratae) and the Acalyptratae in a typical Brachycera cluster. The identification of diagnostic restriction sites on the sequenced mitochondrial genome and the correlation with previous RFLP analysis are discussed...
  23. ncbi Flight activity alters velocity tuning of fly motion-sensitive neurons
    Sarah Nicola Jung
    Department Systems and Computational Neurobiology, Max Planck Institute for Neurobiology, D 82152 Martinsried, Germany
    J Neurosci 31:9231-7. 2011
    ..CDM has been previously shown to induce arousal in flies. We found that flying as well as the application of CDM significantly broadens the velocity tuning of H1 toward higher velocities...
  24. ncbi The development and evolution of bristle patterns in Diptera
    P Simpson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
    Development 126:1349-64. 1999
    The spatial distribution of sensory bristles on the notum of different species of Diptera is compared...
  25. ncbi A new Sodalis lineage from bloodsucking fly Craterina melbae (Diptera, Hippoboscoidea) originated independently of the tsetse flies symbiont Sodalis glossinidius
    Eva Novakova
    Faculty of Biological Sciences and Institute of Parasitology, Ceske Budejovice, Czech Republic
    FEMS Microbiol Lett 269:131-5. 2007
  26. pmc BMP signaling components in embryonic transcriptomes of the hover fly Episyrphus balteatus (Syrphidae)
    Steffen Lemke
    University of Chicago, Dept, of Organismal Biology and Anatomy, CLSC 921B, 920 E, 58th Street, Chicago, IL 60637, USA
    BMC Genomics 12:278. 2011
    ..The closest relatives of D. melanogaster with clearly distinct DV differentiation are hover flies (Diptera: Syrphidae)...
  27. ncbi Sand fly vectors (Diptera, Psychodidae) of American visceral leishmaniasis areas in the Atlantic Forest, State of Espírito Santo, southeastern Brazil
    Israel de Souza Pinto
    Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, CEP 21040 360, Rio de Janeiro, RJ, Brazil
    J Vector Ecol 37:90-6. 2012
    ..Therefore, Evandromyia lenti may be used as an index species for the occurrence of Lutzomyia longipalpis...
  28. ncbi BMP-dependent serosa and amnion specification in the scuttle fly Megaselia abdita
    Ab Matteen Rafiqi
    University of Chicago, Department of Organismal Biology and Anatomy, Chicago, IL 60637, USA
    Development 139:3373-82. 2012
    ..We propose that changes in the BMP activity profile at the beginning of gastrulation might have contributed to the reduction of extra-embryonic tissue types during the radiation of cyclorrhaphan flies...
  29. ncbi Insect succession and carrion decomposition in selected forests of Central Europe. Part 3: Succession of carrion fauna
    Szymon Matuszewski
    Department of Criminalistics, Adam Mickiewicz University, Sw Marcin 90, 61 809 Poznań, Poland
    Forensic Sci Int 207:150-63. 2011
    ..Implications for methods of PMI estimation (particularly the succession-based method) are discussed...
  30. ncbi A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
    W McGinnis
    Cell 37:403-8. 1984
    ..Apparently at least a part of these developmental switch genes from Drosophila is highly conserved during evolution, and might perform an analogous function in many metazoans ...
  31. ncbi A preliminary investigation of insect colonisation and succession on remains in New Zealand
    Terry L Eberhardt
    The University of Auckland, Department of Chemistry, Forensic Science Programme, Building 301, Level 5, 23 Symonds St, Auckland, New Zealand
    Forensic Sci Int 176:217-23. 2008
    ..This preliminary investigation presents a broad outline of the insects associated with remains and the order in which they appear in the Auckland region...
  32. ncbi Purification and characterization of an antimicrobial peptide, insect defensin, from immunized house fly (Diptera: Muscidae)
    X L Dang
    School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    J Med Entomol 47:1141-5. 2010
    The house fly, Musca domestica L. (Diptera: Muscidae), is involved in phoretic movement of pathogenic agents, but it has a very efficient defense mechanism against infection...
  33. ncbi Spatial and temporal variability of necrophagous Diptera from urban to rural areas
    C Hwang
    Department of Life Sciences, King s College London, UK
    Med Vet Entomol 19:379-91. 2005
    ..Correspondence analysis showed clearly seasonal patterns at Box Hill site. The species-habitat associations suggest habitat differentiation between necrophagous guilds in this area and may be of ecological value...
  34. ncbi Molecular phylogenetics of the holly leafminers (Diptera: Agromyzidae: Phytomyza): species limits, speciation, and dietary specialization
    S J Scheffer
    Systematic Entomology Laboratory, USDA, Agricultural Research Service, Beltsville, Maryland 20705, USA
    Mol Phylogenet Evol 17:244-55. 2000
    ..Monophagy is the most common feeding pattern in holly leafminers, and more generalized feeding is inferred to have evolved at least two separate times, possibly as a prelude to speciation...
  35. ncbi Simplified media for spiroplasmas associated with tabanid flies
    Rebekah W Moulder
    Department of Biology, Georgia Southern University, Statesboro 30460 8042, USA
    Can J Microbiol 48:1-6. 2002
    ..and deer flies (Chrysops spp.) (Diptera: Tabanidae) have been accomplished in the complex M1D medium...
  36. ncbi Detection of Cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibody
    Thaddeus K Graczyk
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 68:228-32. 2003
  37. ncbi Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera
    C Wülbeck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 127:1411-20. 2000
    ..Other species of derived schizophoran Diptera have equally stereotyped, but different, bristle patterns...
  38. pmc Myiasis
    Fabio Francesconi
    Dermatology Section, Universidade Federal do Amazonas, Brazil
    Clin Microbiol Rev 25:79-105. 2012
    ..In this review, we deeply discuss myiasis as a worldwide infestation with different agents and with its broad scenario of clinical manifestations as well as diagnosis techniques and treatment...
  39. ncbi Bartonella species in bat flies (Diptera: Nycteribiidae) from western Africa
    S A Billeter
    Centers for Disease Control and Prevention, Division of Vector Borne Diseases, Fort Collins, Colorado, USA
    Parasitology 139:324-9. 2012
    ..A survey was conducted to identify whether Cyclopodia greefi greefi (Diptera: Nycteribiidae) collected from Ghana and 2 islands in the Gulf of Guinea harbour Bartonella...
  40. ncbi Conservation and sex-specific splicing of the doublesex gene in the economically important pest species Lucilia cuprina
    Carolina Concha
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    J Genet 89:279-85. 2010
    ..This intron/exon arrangement had previously been found only in the housefly dsx gene, suggesting this may be a unique feature of dsx genes of Calyptratae species...
  41. ncbi Virulence analysis of Hessian fly populations from Texas, Oklahoma, and Kansas
    Ming Shun Chen
    Plant Science and Entomology Research Unit, Grain Marketing and Production Research Center, USDA ARS, 1515 College Ave, Manhattan, KS 66506, USA
    J Econ Entomol 102:774-80. 2009
    ..97) with the percentages of susceptible plants in a virulence test. This suggests that virulence assays, which require less time and effort, can be used to approximate biotype composition...
  42. ncbi Maternal and paternal condition effects on offspring phenotype in Telostylinus angusticollis (Diptera: Neriidae)
    R Bonduriansky
    Evolution and Ecology Research Centre, and School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia
    J Evol Biol 20:2379-88. 2007
    ..In such species, the transfer of paternal condition to offspring could contribute to indirect selection on female mate preferences...
  43. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  44. ncbi Placement of Conopidae (Diptera) within Schizophora based on mtDNA and nrDNA gene regions
    Joel F Gibson
    Agriculture and Agri Food Canada, Canadian National Collection of Insects, Arachnids and Nematodes, Ottawa, Ontario, Canada
    Mol Phylogenet Evol 56:91-103. 2010
    ..using molecular characters, as well as the largest molecular analysis of relationships within Schizophora (Diptera) to date, is presented...
  45. ncbi Variability in spike trains during constant and dynamic stimulation
    A K Warzecha
    Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501 Bielefeld, Germany
    Science 283:1927-30. 1999
    ..For large parts of the neuron's activity range, the variability of the responses was very similar for constant and time-varying stimuli and was considerably smaller than that in many visual interneurons of vertebrates...
  46. ncbi A comparative analysis of the evolution of imperfect mimicry
    Heather D Penney
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, K1S 5B6, Canada
    Nature 483:461-4. 2012
    ..For example, many hoverflies (Diptera: Syrphidae) are harmless (Batesian) mimics of stinging Hymenoptera...
  47. ncbi Serine proteinase inhibitors in arthropod immunity
    M R Kanost
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    Dev Comp Immunol 23:291-301. 1999
    ..Some may inhibit fungal or bacterial proteinases. Others probably have roles in regulating endogenous proteinases involved in coagulation, prophenol oxidase activation, or cytokine activation...
  48. ncbi The mitochondrial genome of the mediterranean fruit fly, Ceratitis capitata
    L Spanos
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Crete, Greece
    Insect Mol Biol 9:139-44. 2000
    ..Moreover, they could help obtain a solution to the long-lasting controversy on the possible eradication of the Medfly from certain locations...
  49. ncbi The tropical African latrine blowfly, Chrysomya putoria (Wiedemann)
    B R Laurence
    London School of Hygiene and Tropical Medicine
    Med Vet Entomol 2:285-91. 1988
    ..chloropyga (Wiedemann, 1818) (Diptera: Calliphoridae). The biology of C...
  50. ncbi The phylogeny and evolution of host choice in the Hippoboscoidea (Diptera) as reconstructed using four molecular markers
    Frederik Torp Petersen
    Zoological Museum, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen Ø, Denmark
    Mol Phylogenet Evol 45:111-22. 2007
    Hippoboscoidea is a superfamily of Diptera that contains the Glossinidae or tsetse flies, the Hippoboscidae or louse flies, and two families of bat flies, the Streblidae and the Nycteribiidae...
  51. ncbi Transfer of visual motion information via graded synapses operates linearly in the natural activity range
    R Kurtz
    Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501 Bielefeld, Germany
    J Neurosci 21:6957-66. 2001
    ..Thus, the inevitably limited range in which the gain of overall synaptic signal transfer is constant appears to be adjusted to sensory input strengths...
  52. pmc Central gating of fly optomotor response
    Juergen Haag
    Department of Systems and Computational Neurobiology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 107:20104-9. 2010
    ..While head movements of flies have only a small amplitude when flies are at rest, the response amplitude is increased by a factor of 30-40 during flight...
  53. ncbi Larvae of related Diptera species from thermally contrasting habitats exhibit continuous up-regulation of heat shock proteins and high thermotolerance
    David G Garbuz
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, 119991 Moscow, Russia
    Mol Ecol 17:4763-77. 2008
    A population of Stratiomys japonica, a species belonging to the family Stratiomyidae (Diptera), common name 'soldier flies', occurs in a hot volcanic spring, which is apparently among the most inhospitable environments for animals ..
  54. ncbi Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution
    Simon L Bullock
    Cancer Research UK, Developmental Genetics Laboratory, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:4251-61. 2004
    ..We find that although localisation of wingless transcripts is conserved in Diptera, localisation of even-skipped and hairy pair-rule transcripts is evolutionarily labile and correlates with taxon-..
  55. ncbi Against all odds: explaining high host specificity in dispersal-prone parasites
    Carl W Dick
    Department of Zoology, Field Museum of Natural History, Chicago, IL 60605 2496, USA
    Int J Parasitol 37:871-6. 2007
  56. ncbi The geographical mosaic of coevolution in a plant-pollinator mutualism
    Bruce Anderson
    School of Biological and Conservation Sciences, University of KwaZulu Natal, P Bag X01, Scottsville, Pietermaritzburg, South Africa
    Evolution 62:220-5. 2008
    ..We conclude that coevolution is a compelling explanation for the geographical covariation in flower depth and fly proboscis length...
  57. ncbi Encoding of naturalistic optic flow by a population of blowfly motion-sensitive neurons
    K Karmeier
    Department of Neurobiology, Faculty for Biology, Bielefeld University, Bielefeld, Germany
    J Neurophysiol 96:1602-14. 2006
  58. pmc Male sexual ornament size is positively associated with reproductive morphology and enhanced fertility in the stalk-eyed fly Teleopsis dalmanni
    David W Rogers
    The Galton Laboratory, Research Department of Genetics, Evolution and Environment, University College London, 4 Stephenson Way, London, NW1 2HE, UK
    BMC Evol Biol 8:236. 2008
    ..Here we investigate whether male eyespan indicates accessory gland and testis length, and then ask whether mating with large eyespan males affects female fertility...
  59. ncbi Factors affecting decomposition and Diptera colonization
    C P Campobasso
    Section of Legal Medicine (DI.M.I.M.P, University of Bari, Piazza Giulio Cesare, 70100 Policlinico-Bari, Italy
    Forensic Sci Int 120:18-27. 2001
    ..On account of their activity and world wide distribution, Diptera are the insects of greatest forensic interest...
  60. ncbi Phylogenetic relationships among fruit flies, Bactrocera (Diptera, Tephritidae), based on the mitochondrial rDNA sequences
    M Muraji
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
    Insect Mol Biol 10:549-59. 2001
    ..The results are discussed in relation to the taxonomic positions of species used in this study and in relation to the phylogenetic and diagnostic utility of the mitochondrial rDNA fragment...
  61. ncbi Nonlinear, binocular interactions underlying flow field selectivity of a motion-sensitive neuron
    Karl Farrow
    Max Planck Institute of Neurobiology, Department of Systems and Computational Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Neurosci 9:1312-20. 2006
    ..This is accomplished through a modulation of H2's membrane potential by input from the contralateral HSE cell, which scales the firing rate of H2 during visual stimulation but is not sufficient to induce action potentials...
  62. ncbi On the computations analyzing natural optic flow: quantitative model analysis of the blowfly motion vision pathway
    J P Lindemann
    Department of Neurobiology, Faculty for Biology, Bielefeld University, D 33501 Bielefeld, Germany
    J Neurosci 25:6435-48. 2005
  63. pmc Functional characterization of HFR1, a high-mannose N-glycan-specific wheat lectin induced by Hessian fly larvae
    Subhashree Subramanyam
    Department of Agronomy, Purdue University, West Lafayette, Indiana 47907, USA
    Plant Physiol 147:1412-26. 2008
    ..Thus, HFR1 is an antinutrient to dipteran larvae and may play a significant role in deterring Hessian fly larvae from feeding on resistant wheat plants...
  64. ncbi Adaptation of response transients in fly motion vision. II: Model studies
    Alexander Borst
    Department of Systems and Computational Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Vision Res 43:1309-22. 2003
    ..Moreover, such an elaborated model with an adaptive time-constant faithfully mimics a particular contrast-dependency of transient response oscillations observed in fly motion sensitive neurons...
  65. ncbi Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands
    Xueqing Xu
    Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Mol Cell Proteomics 7:582-90. 2008
    ..of the host, were identified and characterized from 30,000 pairs salivary glands of the horsefly Tabanus yao (Diptera, Tabanidae)...
  66. ncbi The transformer gene in Ceratitis capitata provides a genetic basis for selecting and remembering the sexual fate
    Attilio Pane
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    Development 129:3715-25. 2002
    ..The male pathway seems to result when Cctra autoregulation is prevented and instead splice variants with truncated open reading frames are produced. We propose that this repression is achieved by the Y-linked male-determining factor (M)...
  67. pmc Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh fly
    Gregory J Ragland
    Department of Entomology and Nemtaology, University of Florida, Gainesville, FL 32611 0620, USA
    Proc Natl Acad Sci U S A 107:14909-14. 2010
  68. pmc Mechanical transmission of human protozoan parasites by insects
    Thaddeus K Graczyk
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Microbiol Rev 18:128-32. 2005
    ..Mechanical transmission of human parasites by nonbiting flies and epidemiological involvement of other synanthropic insects in human food-borne diseases have not received adequate scientific attention...
  69. ncbi Recurrent network interactions underlying flow-field selectivity of visual interneurons
    J Haag
    Division of Insect Biology, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720-3112, USA
    J Neurosci 21:5685-92. 2001
    ..In addition to feedforward connectivity, thus, the flow-field selectivity of LPTCs may be significantly attributable to recurrent excitation involving the network of large-field neurons in both brain hemispheres...
  70. ncbi Response latency of a motion-sensitive neuron in the fly visual system: dependence on stimulus parameters and physiological conditions
    A Warzecha
    Lehrstuhl für Neurobiologie, Fakultat fur Biologie, Universitat Bielefeld, Postfach 10 01 31, D 33501, Bielefeld, Germany
    Vision Res 40:2973-83. 2000
    ..Since response latencies cover a range of one order of magnitude, the latency changes are expected to be of relevance in visually guided orientation behaviour...
  71. ncbi Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativa
    Li Hua Huang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, B5 Datun Road, Chaoyang District, Beijing 100101, China
    J Insect Physiol 55:279-85. 2009
    ..These results suggest that, in addition to a heat shock response, these HSPs may be involved in the development of L. sativae...
  72. ncbi The black soldier-fly, Hermetia illucens (Diptera, Stratiomyidae), used to estimate the postmortem interval in a case in Amapá State, Brazil
    José R Pujol-Luz
    Departamento de Zoologia and Núcleo de Entomologia Urbana e Forense, Universidade de Brasilia, Brasilia, DF, Brazil
    J Forensic Sci 53:476-8. 2008
    ..Since H. illucens usually (but not always) colonizes corpses in more advanced stages of decay, this estimate is consistent with the hypothesis that the child was killed immediately after abduction...
  73. pmc Reductive genome evolution, host-symbiont co-speciation and uterine transmission of endosymbiotic bacteria in bat flies
    Takahiro Hosokawa
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    ISME J 6:577-87. 2012
    ..The designation 'Candidatus Aschnera chinzeii' is proposed for the endosymbiont clade...
  74. ncbi The use of COI barcodes for molecular identification of forensically important fly species in Germany
    Petra Boehme
    Institute of Forensic Medicine, Goethe University Frankfurt, Kennedyallee 104, 60596, Frankfurt am Main, Germany
    Parasitol Res 110:2325-32. 2012
    ..oxidase I gene "barcoding region" as a universal marker for molecular identification of forensically important Diptera. We analyzed 111 specimens belonging to 13 species originating from Frankfurt am Main, Germany (Calliphoridae: ..
  75. ncbi The molecular systematics of blowflies and screwworm flies (Diptera: Calliphoridae) using 28S rRNA, COX1 and EF-1α: insights into the evolution of dipteran parasitism
    Laura M McDonagh
    College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX44QD, UK
    Parasitology 138:1760-77. 2011
    ..In summary, this study represents the most comprehensive molecular phylogenetic analysis of family Calliphoridae undertaken to date...
  76. ncbi Differential decomposition patterns in charred versus un-charred remains
    Ariel Gruenthal
    School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK
    J Forensic Sci 57:12-8. 2012
    ..Body regions displaying significant charring decomposed at a faster rate (p < 0.001), while areas with very light levels of charring decomposed at a significantly slower rate (p < 0.001)...
  77. ncbi Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands
    Peter Takac
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovak Republic
    J Exp Biol 209:343-52. 2006
    ..Here we describe the first evidence of vasodilators in horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary gland extract and clone and express one of the active peptides (termed vasotab)...
  78. ncbi External ophthalmomyiasis by oestrus ovis: an unknown endemic eye disease in rural parts of central India
    S Misra
    Department of Ophthalmology, Rural Medical College, Pravara Medical Trust, Loni 413736, Maharastra, India
    Trop Doct 38:120-2. 2008
  79. ncbi A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous Diptera
    Joanna Richardson
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Dev Genes Evol 216:29-38. 2006
    ..This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera and that many differences are likely to be due to changes in cis-regulatory sequences of scute.
  80. pmc Changing bee and hoverfly pollinator assemblages along an urban-rural gradient
    Adam J Bates
    Geography, Earth and Environmental Sciences, The University of Birmingham, Birmingham, West Midlands, United Kingdom
    PLoS ONE 6:e23459. 2011
    ..We assessed changes in the diversity, abundance and species composition of bee and hoverfly pollinator assemblages in urban, suburban, and rural sites across a UK city...
  81. ncbi The utility of mitochondrial DNA sequences for the identification of forensically important blowflies (Diptera: Calliphoridae) in southeastern Australia
    J F Wallman
    Department of Environmental Biology, The University of Adelaide, Adelaide, 5005 SA, Australia
    Forensic Sci Int 120:60-7. 2001
  82. pmc Chrysomya putoria, a putative vector of diarrheal diseases
    Steven W Lindsay
    School of Biological and Biomedical Sciences, Durham University, Durham City, United Kingdom
    PLoS Negl Trop Dis 6:e1895. 2012
    ..Because of their strong association with human feces and their synanthropic nature, we examined whether these flies are likely to be vectors of diarrheal pathogens...
  83. ncbi An initial study on the succession of sarcosaprophagous Diptera (Insecta) on carrion in the southeastern Iberian peninsula
    I Arnaldos
    Department of Animal Biology (Zoology, Faculty of Biology, University of Murcia, Spain
    Int J Legal Med 114:156-62. 2001
    We present the results of the first study concerning Diptera carried out on the sarcosaprophagous fauna of southeastern Spain...
  84. pmc The key mimetic features of hoverflies through avian eyes
    Roderick S Bain
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Proc Biol Sci 274:1949-54. 2007
  85. ncbi External morphology of Chrysomya pinguis (Walker) (Diptera: Calliphoridae) revealed by scanning electron microscopy
    Kom Sukontason
    Department of Parasitology, Chiang Mai University, Chiang Mai 50200, Thailand
    Micron 39:190-7. 2008
    ..pinguis that was revealed in this study allows us to know such types of structures in much better detail and may eventually provide a basis for understanding some of the biological behavior of this fly species in the future...
  86. ncbi Human and livestock migrations: a history of bot fly biodiversity in the Mediterranean region
    Domenico Otranto
    Department of Animal Health and Welfare of the Faculty of Veterinary Medicine, University of Bari, PO Box 7, 70010 Valenzano Bari, Italy
    Trends Parasitol 22:209-13. 2006
    ..The movement of animals and their associated parasites in this region can help to explain the evolution of parasitic biodiversity...
  87. ncbi Molecular phylogeny of Calyptratae (Diptera: Brachycera): the evolution of 18S and 16S ribosomal rDNAs in higher dipterans and their use in phylogenetic inference
    X Nirmala
    Institute of Parasitology, Academy of Sciences of the Czech Republic,
    Insect Mol Biol 10:475-85. 2001
    ..and Antipoda sp., display a tendency to cluster within Oestroidea. The comparison of secondary structures of two variable regions indicates that Sarcophagidae are related to Calliphoridae rather than to Tachinidae...
  88. pmc Use of cytochrome c oxidase subunit i (COI) nucleotide sequences for identification of the Korean Luciliinae fly species (Diptera: Calliphoridae) in forensic investigations
    Seong Hwan Park
    Department of Legal Medicine, Colloge of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 24:1058-63. 2009
    ..The results suggest that more individuals from various geographic regions and additive nuclear DNA markers should be analyzed, and morphologic identification keys must be reconfirmed to overcome these inconsistencies...
  89. ncbi Insect succession and decomposition patterns on shaded and sunlit carrion in Saskatchewan in three different seasons
    Barbara J Sharanowski
    University of Kentucky, Department of Entomology, S 225 Agricultural Science Center North, Lexington, KY 40546 0091, USA
    Forensic Sci Int 179:219-40. 2008
    ..Members of Silphidae were the first coleopteran colonizers in all habitats and seasons. This paper also marks the first record for Cochliomyia macellaria (Fabricius) in Saskatchewan...
  90. ncbi DNA-based identification of forensically important Australian Sarcophagidae (Diptera)
    Kelly A Meiklejohn
    Institute for Conservation Biology and Environment Management, School of Biological Sciences, University of Wollongong, NSW 2522, Australia
    Int J Legal Med 125:27-32. 2011
    The utility of the forensically important Sarcophagidae (Diptera) for time since death estimates has been severely limited, as morphological identification is difficult and thermobiological histories are inadequately documented...
  91. ncbi Differential divergences of obligately insect-pathogenic Entomophthora species from fly and aphid hosts
    Annette Bruun Jensen
    Department of Agriculture and Ecology, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C, Denmark
    FEMS Microbiol Lett 300:180-7. 2009
    ..rRNA and GPD) of isolates from the insect-pathogenic fungus genus Entomophthora originating from different fly (Diptera) and aphid (Hemiptera) host taxa were sequenced...
  92. pmc External ophthalmomyiasis caused by Oestrus ovis: a rare case report from India
    Anita Pandey
    Department of Microbiology, Subharti Medical College, Meerut, Uttar Pradesh, India
    Korean J Parasitol 47:57-9. 2009
    ..A 25-year-old farmer presented with severe symptoms of conjunctivitis. The larvae, 3 in number, were observed in the bulbar conjunctiva, and following removal the symptoms of eye inflammation improved within a few hours...
  93. ncbi Identifying fly puparia by clearing technique: application to forensic entomology
    Kabkaew L Sukontason
    Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand
    Parasitol Res 101:1407-16. 2007
    ..This provides a key to identifying the puparia of these seven fly species...
  94. ncbi Identification of forensically important Chrysomya (Diptera: Calliphoridae) species using the second ribosomal internal transcribed spacer (ITS2)
    Leigh A Nelson
    Centre for Medical Bioscience, School of Biological Sciences, University of Wollongong, New South Wales 2522, Australia
    Forensic Sci Int 177:238-47. 2008
    The identification of forensically important blowflies of the genus Chrysomya (Diptera: Calliphoridae) may be hampered by their close morphological similarities, especially as immatures...
  95. ncbi Human myiasis in New Zealand: imported and indigenously-acquired cases: the species of concern and clinical aspects
    Jose G B Derraik
    Institute of Natural Sciences, Massey University, Auckland, New Zealand
    N Z Med J 123:21-38. 2010
    ..A number of Diptera (fly) families present in New Zealand have been associated with cases of human myiasis: Calliphoridae (7 species),..
  96. ncbi Variability of blowfly head optomotor responses
    R Rosner
    Lehrstuhl für Neurobiologie, Universitat Bielefeld, Bielefeld, Germany
    J Exp Biol 212:1170-84. 2009
    ..Nevertheless, we find the halteres to be responsible for one component of head jitter movements. This component may be the inevitable consequence of their function as equilibrium and gaze-stabilising organs...
  97. pmc Mechanical transmission of lumpy skin disease virus by Aedes aegypti (Diptera: Culicidae)
    C M Chihota
    Institute for Animal Health, Pirbright Laboratory, Woking, UK
    Epidemiol Infect 126:317-21. 2001
    ..LSDV has long been suspected to be insect transmitted, but these findings are the first to demonstrate this unequivocally, and they suggest that mosquito species are competent vectors...
  98. ncbi Seasonal patterns of arthropods occurring on sheltered and unsheltered pig carcasses in Buenos Aires Province (Argentina)
    N Centeno
    Centro de Estudios e Investigaciones Programa de Investigaciones en Interacciones Biologicas CEI PIIB, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal, B1876BXD, Buenos Aires, Argentina
    Forensic Sci Int 126:63-70. 2002
    ..In the fall, the difference between sheltered and unsheltered carcasses was small (six species on the former and five species on the latter); in spring and summer, the difference was negligible...
  99. pmc Identifying insects with incomplete DNA barcode libraries, African fruit flies (Diptera: Tephritidae) as a test case
    Massimiliano Virgilio
    Royal Museum for Central Africa, Tervuren, Belgium
    PLoS ONE 7:e31581. 2012
    ..relationships between identification performances and distance thresholds in four DNA barcode libraries of Diptera (n = 4270), Lepidoptera (n = 7577), Hymenoptera (n = 2067) and Tephritidae (n = 602 DNA barcodes)...
  100. ncbi Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina
    Richard D Newcomb
    Gene Technologies Sector, The Horticulture and Food Research Institute of New Zealand, Private Bag 92169 Auckland, New Zealand
    J Mol Evol 60:207-20. 2005
    ..Four new sequence haplotypes, not sampled in the survey of extant haplotypes, were obtained that are all associated with susceptibility. This is suggestive of a higher historical level of susceptible allelic diversity at this locus...
  101. ncbi Improving access to the control region and tRNA gene clusters of dipteran mitochondrial DNA
    M T Oliveira
    Laboratório de Genética Animal, Centro de Biologia Molecular e Engenharia Genetica, Departamento de Genetica e Evolucao, Instituto de Biologia, Universidade Estadual de Campinas, CP 6010, CEP 13083 875, Campinas, Sao Paulo, Brazil
    J Med Entomol 43:636-9. 2006
    ..These new primers were useful for investigating the nucleotide information and the structural organization of dipteran mtDNA...

Research Grants78

  1. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..abstract_text> ..
    Melanie H Cobb; Fiscal Year: 2012
    ..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
    RUTH M STEWARD; Fiscal Year: 2010
    ..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
  4. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
  5. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..An interaction between this pathway and 2-catenin may enhance FOXO1-mediated transcription and regulate the anti-osteoclastogenic properties of 2-catenin. ..
  6. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..This study will allow us to understand how mutations of OPA1 cause optic atrophy and explore its novel function in lifespan and provide us a potential opportunity to develop treatments for the disease. ..
  7. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
  8. Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
    CRAIG STUART PIKAARD; Fiscal Year: 2013
    ..Our studies of RNA polymerases IV and V are significant with respect to all of these areas, especially the roles of intergenic noncoding RNAs and siRNAs in chromatin-mediated gene silencing. ..
  9. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    ..abstract_text> ..
  10. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..The purpose of this study is to determine how the oocyte suppresses transposons and the effect of transposons on female reproduction. ..
  11. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..The results of the study are expected to provide a solid foundation for eventually developing control strategies designed to interrupt the sand fly-Bb association. ..
  12. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    Jeffrey A Simon; Fiscal Year: 2012
    ..This research will advance basic understanding of gene regulatory mechanisms and provide knowledge that could impact stem cell applications in medicine and development of anti-cancer strategies. ..
  14. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..These efforts may provide a deeper understanding of mitochondria-related disorders and set the stage for the design of treatments. ..
  15. Molecular Genetics of Caloric Restriction in Aging Flies
    Blanka Rogina; Fiscal Year: 2013
    ..It will reveal how reduced caloric intake affects metabolism and life span, and provide the foundation for the development of new therapies for the treatments of age-associated diseases in humans. ..
  16. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
  17. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..Results of these studies also may provide basic new information about vector-borne human diseases involving mosquitoes, flies, ticks, and other arthropods. ..
  18. Genome-wide Identification of Immediate Early Genes in Insects
    Anandasankar Ray; Fiscal Year: 2012
  19. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    ..abstract_text> ..
  20. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..3) To characterize the effect of SIRT3 on mitochondrial superoxide production and hyperglycemia-induced oxidative stress. 4) To investigate the effect of SIRT3 on adipose oxidative stress during obesity and diabetes in vivo. ..
  21. Role of FUS in ALS
    Haining Zhu; Fiscal Year: 2013
    ..The findings are expected to provide critical insights into the mechanisms by which FUS mutations perturb the RNA processing pathways and ultimately lead to the disease. ..
  22. Mechanisms of Lipid-Induced Hepatic Insulin Resistance
    Gerald I Shulman; Fiscal Year: 2013
  23. Roles for Global Chromatin Structure in C. elegans Longevity
    Siu Sylvia Lee; Fiscal Year: 2010
    ..Our proposed research may lead to future therapeutic development that aims to improve healthy aging and alleviate age-dependent diseases. ..
  24. Regulation of TRP channels and visual transduction
    Craig Montell; Fiscal Year: 2013
    ..Given that the molecular mechanisms underlying the activation of these human TRPs are poorly understood, Drosophila TRP provides an in vivo model for defining the mechanisms regulating TRP channels. ..
  25. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..Studies at these levels of detail are not possible in other species at the present time. ..
  26. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    John W Tamkun; Fiscal Year: 2013
    ..The information gained from this project will therefore be directly relevant to human health. ..
  27. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
  28. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..With the prospect of identifying new molecular targets, and the future application of this model to screen compounds for medications development, this project has a tremendous potential impact for the treatment of human drug addiction. ..
  29. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013
    ..Using this information, human population-based association studies will be performed to investigate the effect of natural variation in the identified regulatory genes on quantitative traits associated with the metabolic syndrome. ..
  30. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..This project will provide avenues to develop proficiency in multiple molecular and physiological techniques that will provide the groundwork for the candidate to become an authority on the molecular physiology of disease vectors. ..
  31. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..This will be followed by the derivation of healthy pups as the basis for future clinical application using R-spondin2 to treat infertile patients with low FSH responses. ..
  32. Role of Cofilin and Wnt Signaling in Neural Crest Development
    O apos NEIL WIGGAN; Fiscal Year: 2013
    ..abstract_text> ..
  33. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..e., BMPs repress CRM activity). We will follow a similar strategy to identify and characterize CRMs driving expression of laterally (Pax6) and ventrally (Nkx2.2.) genes. ..
  34. P. papatasi midgut molecules: gene function and assessing TBV candidates
    JOSE MARCELO contact RAMALHO ORTIGAO; Fiscal Year: 2010
  35. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
  36. De novo establishment of Polycomb-group-mediated repression
    Richard S Jones; Fiscal Year: 2010
  37. Pathophysiology and potential therapy for a childhood neurodegenerative disease
    Marquis T Walker; Fiscal Year: 2011
    ..This proposed work is relevant to the understanding and treatment of MLIV, and to improving the lives of MLIV patients. ..
  38. 2011 Cell-Cell Fusion Gordon Research Conference and Seminar
    NANCY RYAN GRAY; Fiscal Year: 2011
  39. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2013
    ..These elements stand to provide targets for tsetse specific vector control strategies for use in the prevention of trypanosomiasis. ..
  40. Novel histone biotinylation sites and relationships to other epigenetic marks
    JANOS contact ZEMPLENI; Fiscal Year: 2010
    ..Previous studies suggest that biotinylation of histones plays a critical role in the repression of retrotransposons, thereby decreasing the incidence of retrotranspositions, chromosomal abnormalities, and probably cancer risk. ..
  41. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..In this proposal we will characterize how addition of glucose residues to the Notch protein fine-tunes signaling mediated by this important pathway. ..
  42. Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
    PETER H SPORN; Fiscal Year: 2013
    ..The results should lay the basis for future studies aimed at preventing hypercapnic immune suppression in patients with advanced lung disease. ..
  43. Generation of Wunen/LPP3-based therapy for muscular dystrophy
    Hannele Ruohola Baker; Fiscal Year: 2010
    ..Ultimately, in the future we wish to test whether manipulating sphingolipid metabolism can serve therapeutic function in muscular dystrophy treatment. ..
  44. Physiology of Class III PI 3-kinase Signaling 2
    Jonathan M Backer; Fiscal Year: 2013
    ..Given that hVps34 is one of the key kinases involved in autophagy, a better understanding of its regulation will lead to new insights into this critical cellular process. ..
    Salvatore J Turco; Fiscal Year: 2012
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  46. Mechanisms of glucosensation mediating food choice behavior in Drosophila
    Monica Dus; Fiscal Year: 2013
    ..They will also provide mammalian researchers with conserved genes to use as molecular and neurochemical markers in future studies of glucosensation, feeding, and disease. ..
  47. Genetic and Molecular Mechanisms of Ethanol-Induced Developmental Defects
    RACHAEL LOUISE FRENCH; Fiscal Year: 2013
  48. 2011 Cold Spring Harbor Conference on Telomeres and Telomerase
    David J Stewart; Fiscal Year: 2010
    ..The 2011 meeting will result in vigorous discussion and synergistic interactions stimulated by the presentation of a large body of unpublished data. ..
  49. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ..Studies of Drosophila as model arthropods may provide insight into persistence of V. cholerae in the environment and suggest ways to prevent or limit pandemic disease. ..
  50. Sestrin1-knockout mice as a model of facilitated muscle aging
    Jun Hee Lee; Fiscal Year: 2013
    ..As Sesn1 is generally downregulated during muscle pathology in humans, supplementing Sesn1 activity through viral or pharmacological means may offer innovative rejuvenation methods for degenerating muscle in elderly population. ..
  51. Aging specific gene expression in Drosophila
    JOHN GERARD TOWER; Fiscal Year: 2013
    ..By studying gene expression in aging Drosophila, we hope to better understand the basic mechanisms of aging, and to ultimately develop interventions for human aging-related diseases. ..
  52. Octopamine Neuroanatomy and Functioning in Fruit Fly Social Behavior
    KYLE LYNN GOBROGGE; Fiscal Year: 2013
    ..This research program represents first steps in elaborating the neural circuitry underlying social behavior in fruit flies. ..
  53. Meiotic spindle formation in Drosophila females
    Kim S McKim; Fiscal Year: 2010
    ..The objective of these studies is to understand how these errors occur. ..
  54. Steroid-Dependent Changes in the Yorkie Interactome
    Alexey Veraksa; Fiscal Year: 2013
    ..In the second aim, we will use the diverse array of genetic tools in Drosophila to assess the role of individual YNI proteins (identified in the AP- MS experiments) in controlling Yki activity in developing tissues. ..
  55. Hormonal Modulation of Aggression in Drosophila
    Edward A Kravitz; Fiscal Year: 2013
    ..Studies exploring the roles of amine neurons in behavior at this level of detail just are not possible with other model systems at the present time. ..
  56. Interplay between the Endocrine and Innate Systems of Drosphila
    Neal Silverman; Fiscal Year: 2013
    ..In Aim 3, we will test a novel alternative hypothesis that steroid-regulated immune signaling and antimicrobial peptides (AMPs) production facilitate developmental cell death. ..
  57. Redefining Human Myocardial Biology
    Annarosa Leri; Fiscal Year: 2013
    ..Stem cell therapy may be prospected as a novel therapeutic strategy for the failing heart. ..
  58. Molecular Basis of Noonan Syndrome and Related Disorder
    Bruce D Gelb; Fiscal Year: 2013
    ..Successful drugs and compounds would likely be useful for most of the RASopathies and for other important clinical aspects such as developmental delays. ..
  59. Drosophila feeding behavior: New tools for the genetic dissection of prandiology
    William W Ja; Fiscal Year: 2012
    ..These discoveries are vital to the development of new therapeutics as well as preventative measures for obesity and other diseases. ..
  60. Role of Chromatin in Genomic Maintenance
    David A Sinclair; Fiscal Year: 2012
  61. Genetic Analysis of Ataxia-telangiectasia
    DAVID WASSARMAN; Fiscal Year: 2012
    ..We have established a Drosophila A-T model that mimics features of neurodegeneration in A-T patients. Using this model we propose to identify gene targets for therapeutic approaches that protect neurons from degeneration in A-T. ..
  62. Nuclear mechanics and mechanotransduction in muscular laminopathies
    Jan Lammerding; Fiscal Year: 2013
  63. Investigations of the role of house flies as vectors for bacterial pathogens
    Dana Nayduch; Fiscal Year: 2009
    ..expression repertoire that was tailored to each species of bacteria tested, and has not been described in other diptera. The proposed study will further examine the spatial (tissue specific) and temporal expression of these molecules ..
  64. The role of sand fly saliva in visceralization of Leishmania parasites
    Gregory Lanzaro; Fiscal Year: 2009
    ..Finally, in Aim #3, we will evaluate the immunomodulatory properties of maxadilan variants found in natural populations of Lu. longipalpis from Brazil and Costa Rica. ..
  65. Leishmania major nucleoside hydrolase inhibitors
    Claude Selitrennikoff; Fiscal Year: 2007
    ..We expect that our work will lead to new compounds with a specific and known mechanism of action that will be useful for the treatment of human leishmaniasis. [unreadable] [unreadable] [unreadable]..
    EDDIE CUPP; Fiscal Year: 1993
    ..The latter will be evaluated for possible "activation" by filarial antigen and blastogenic response. Changes in hemolymph proteins between uninfected and infected flies will be compared using SDS-PAGE...
  67. Nucleoside hydrolase Inhibitors from natural products for Leishmania
    ESTEBAN EDWARD MENA; Fiscal Year: 2010
    ..Also, there is a concern that leishmaniasis could become more widespread in the United States. Our goal is to identify compounds that can be developed for the effective treatment of Leishmaniasis. ..
  68. Establishing Drosophila as a Model to Study Hutchinson-Gilford Progeria Syndrome
    Sandra Schulze; Fiscal Year: 2009
    ..But it is also very probable that unraveling the biology of this unusual disease will go some way to explaining the root causes of aging in general, a genetic disease which affects us all. ..
  69. A novel vaccine against Leishmania
    Claude Selitrennikoff; Fiscal Year: 2005
    ..We believe that this work will lead to the development of prophylactic and therapeutic vaccines against Leishmania ..
  70. New drugs for the treatment of leishmaniasis
    Claude Selitrennikoff; Fiscal Year: 2004
    ..Ultimately, this work will lead to the identification of a lead compound for human clinical trials for the treatment of leishmaniasis. ..
    Leonard Munstermann; Fiscal Year: 2000
    ..The objective of this project is to continue the study of the genetics and biogeography of phlebotomine sand flies (Diptera: Psychodidae)...
  72. Ecdysone modulation of sexual behavior in Drosophila melanogaster
    GEOFFREY GANTER; Fiscal Year: 2009
    ..Determination of the mechanisms by which ecdysone controls sexual behavior will result in important clues about the normal function of steroid hormones in controlling the sexual behavior of all animals, including humans. ..
    MATTHEW WALLENFANG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  74. A Drosophila Model for Williams Syndrome Cognitive Processing
    Ralph J Greenspan; Fiscal Year: 2010
    ..Accordingly, the study of WS gives us the opportunity to identify, firsthand, genes that influence behavior and cognition. ..
  75. Clade-specific changes in transcription of olfactory genes in fruit flies
    EREZYILMAZ DENIZ; Fiscal Year: 2009
    ..This study will complement those that are restricted to the D. melanogaster model system, and will have implications for the general study of development and neuronal differentiation. ..
  76. Understanding the Mechanism of RNA Interference (RNAi)
    Phillip Zamore; Fiscal Year: 2009
  77. Meeting:Society for Integrative and Comparative Biology
    Neil Blackstone; Fiscal Year: 2004
    ..Ultimately, this work will allow the power of genomics to be fully realized in biology and medicine. ..
    Harry Drabkin; Fiscal Year: 2006
    ..Lastly, because wt DTrc8 induces Minute-like phenotypes in adult sensory hairs, the MPN domains of eIF3h and eIF3f will be tested for interactions and further characterized if positive. ..