tupaiidae

Summary

Summary: The only family of the order SCANDENTIA, variously included in the order Insectivora or in the order Primates, and often in the order Microscelidea, consisting of five genera. They are TUPAIA, Ananthana (Indian tree shrew), Dendrogale (small smooth-tailed tree shrew), Urogale (Mindanao tree shrew), and Ptilocercus (pen-tailed tree shrew). The tree shrews inhabit the forest areas of eastern Asia from India and southwestern China to Borneo and the Philippines.

Top Publications

  1. pmc Retinal origin of orientation maps in visual cortex
    Se Bum Paik
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Neurosci 14:919-25. 2011
  2. doi Functional and laminar dissociations between muscarinic and nicotinic cholinergic neuromodulation in the tree shrew primary visual cortex
    Anwesha Bhattacharyya
    Visual Cognition Laboratory, Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Eur J Neurosci 35:1270-80. 2012
  3. ncbi The tree shrews: adjuncts and alternatives to primates as models for biomedical research
    J Cao
    Department of Pathology, Guangxi Cancer Institute, Guangxi Medical University, Nanning, China
    J Med Primatol 32:123-30. 2003
  4. doi Neural response dynamics of spiking and local field potential activity depend on CRT monitor refresh rate in the tree shrew primary visual cortex
    Julia Veit
    Visual Cognition Laboratory, Dept of Medicine, Univ of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    J Neurophysiol 106:2303-13. 2011
  5. pmc The effect of age on compensation for a negative lens and recovery from lens-induced myopia in tree shrews (Tupaia glis belangeri)
    Thomas T Norton
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, United States
    Vision Res 50:564-76. 2010
  6. pmc Layer 2/3 synapses in monocular and binocular regions of tree shrew visual cortex express mAChR-dependent long-term depression and long-term potentiation
    Portia McCoy
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurophysiol 100:336-45. 2008
  7. pmc Binocular lens treatment in tree shrews: Effect of age and comparison of plus lens wear with recovery from minus lens-induced myopia
    John T Siegwart
    Department of Vision Sciences, School of Optometry, 302 Worrell Building, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Exp Eye Res 91:660-9. 2010
  8. pmc Refractive state of tree shrew eyes measured with cortical visual evoked potentials
    Thomas T Norton
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, 606 Worrell Building, Birmingham, AL 35294 4390, USA
    Optom Vis Sci 80:623-31. 2003
  9. pmc Modulation of glycosaminoglycan levels in tree shrew sclera during lens-induced myopia development and recovery
    Anisha G Moring
    Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Invest Ophthalmol Vis Sci 48:2947-56. 2007
  10. ncbi Regulation of the mechanical properties of tree shrew sclera by the visual environment
    J T Siegwart
    Department of Physiological Optics, University of Alabama at Birmingham 35294 4390, USA
    Vision Res 39:387-407. 1999

Research Grants

  1. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
  2. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2006
  3. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
  4. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2007
  5. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
  6. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
  7. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2001
  8. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 1993
  9. The role of short-range horizontal connections in cortical computation
    STEPHEN VAN HOOSER; Fiscal Year: 2007
  10. Information Transfer from LGN to Primary Visual Cortex
    STEPHEN VAN HOOSER; Fiscal Year: 2004

Detail Information

Publications126 found, 100 shown here

  1. pmc Retinal origin of orientation maps in visual cortex
    Se Bum Paik
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Neurosci 14:919-25. 2011
    ..Further, it offers a possible account for the emergence of orientation tuning in single neurons despite the absence of orderly orientation maps in rodents species...
  2. doi Functional and laminar dissociations between muscarinic and nicotinic cholinergic neuromodulation in the tree shrew primary visual cortex
    Anwesha Bhattacharyya
    Visual Cognition Laboratory, Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Eur J Neurosci 35:1270-80. 2012
    ..Our findings suggest close homology between cholinergic mechanisms in tree shrew and primate visual cortices...
  3. ncbi The tree shrews: adjuncts and alternatives to primates as models for biomedical research
    J Cao
    Department of Pathology, Guangxi Cancer Institute, Guangxi Medical University, Nanning, China
    J Med Primatol 32:123-30. 2003
    ..However, the tree shrews holds significant promise as research models and great use could be made of these animals in biomedical research...
  4. doi Neural response dynamics of spiking and local field potential activity depend on CRT monitor refresh rate in the tree shrew primary visual cortex
    Julia Veit
    Visual Cognition Laboratory, Dept of Medicine, Univ of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    J Neurophysiol 106:2303-13. 2011
    ..Taken together, our findings reveal many similarities between V1 of macaque and tree shrew, while underscoring a greater temporal sensitivity of the tree shrew visual system...
  5. pmc The effect of age on compensation for a negative lens and recovery from lens-induced myopia in tree shrews (Tupaia glis belangeri)
    Thomas T Norton
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, United States
    Vision Res 50:564-76. 2010
    ..The time-course of recovery is more variable than that of compensation and seems to vary with age, with the amount of myopia (weakly) and with the individual animal...
  6. pmc Layer 2/3 synapses in monocular and binocular regions of tree shrew visual cortex express mAChR-dependent long-term depression and long-term potentiation
    Portia McCoy
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurophysiol 100:336-45. 2008
    ..However, depending on the ocular inputs to that region, variation exists as to the direction of plasticity, as well as to the specific mAChR and signaling mechanisms that are required...
  7. pmc Binocular lens treatment in tree shrews: Effect of age and comparison of plus lens wear with recovery from minus lens-induced myopia
    John T Siegwart
    Department of Vision Sciences, School of Optometry, 302 Worrell Building, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Exp Eye Res 91:660-9. 2010
    ..If juvenile human eyes, compared with infants, have a similar difficulty in using myopia to slow axial elongation, this may contribute to myopia development, especially in eyes with a genetic pre-disposition to elongate...
  8. pmc Refractive state of tree shrew eyes measured with cortical visual evoked potentials
    Thomas T Norton
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, 606 Worrell Building, Birmingham, AL 35294 4390, USA
    Optom Vis Sci 80:623-31. 2003
    ..To determine the refractive state of tree shrew eyes using visual evoked potentials (VEP's) recorded from primary visual cortex and compare the values with those obtained with streak retinoscopy and with an autorefractor...
  9. pmc Modulation of glycosaminoglycan levels in tree shrew sclera during lens-induced myopia development and recovery
    Anisha G Moring
    Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Invest Ophthalmol Vis Sci 48:2947-56. 2007
    ..This study investigated the unsulfated and sulfated GAG composition of the sclera during compensation for a -5 diopter (D) lens and during recovery...
  10. ncbi Regulation of the mechanical properties of tree shrew sclera by the visual environment
    J T Siegwart
    Department of Physiological Optics, University of Alabama at Birmingham 35294 4390, USA
    Vision Res 39:387-407. 1999
    ....
  11. ncbi Retinal acetylcholine content in normal and myopic eyes: a role in ocular growth control?
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Vis Neurosci 18:571-80. 2001
    ..5%) and chicks (dopamine -12.3% and DOPAC -28.2%). These findings demonstrate that, contrary to dopamine and DOPAC content, steady-state retinal acetylcholine and choline content is not significantly altered during myopia development...
  12. pmc Molecular phylogeny of the superorder Archonta
    R M Adkins
    Department of Wildlife and Fisheries Sciences, Texas A and M University, College Station 77843 2258
    Proc Natl Acad Sci U S A 88:10317-21. 1991
    ..Analyses of the cytochrome oxidase subunit II gene give marginally more support to a Dermoptera-Scandentia clade than to a Dermoptera-Primates clade...
  13. ncbi Characterization of the integrin receptor subunit profile in the mammalian sclera
    Ravikanth Metlapally
    Department of Optometry and Vision Sciences, University of Melbourne, Carlton, Victoria, Australia
    Mol Vis 12:725-34. 2006
    ..As integrin receptors may have a role in remodeling during myopia, this study detailed subunit gene expression in the mammalian sclera...
  14. pmc Flying lemurs--the 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade
    Wenhui Nie
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People s Republic of China
    BMC Biol 6:18. 2008
    ....
  15. ncbi Selective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery
    John Thomas Siegwart
    Department of Vision Sciences, School of Optometry, The University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Vis 13:1878-86. 2007
    ..To better characterize the role of proteoglycans in scleral tissue remodeling during the development of minus lens induced myopia and during recovery in tree shrews...
  16. ncbi Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression
    Andrew I Jobling
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 279:18121-6. 2004
    ..In addition, the early alterations in TGF-beta expression levels may reflect a role for these cytokines in mediating the retinoscleral signal that controls myopic eye growth...
  17. ncbi Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma
    Xinping Xu
    Laboratory for Molecular and Cellular Immunology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    J Gen Virol 88:2504-12. 2007
    ..Thus, tree shrews without immunosuppression can be infected efficiently by native HCV and HCVcc when the animal is inoculated with an adequate amount of single-genotype HCV...
  18. ncbi Depressed neurogenesis and its role in the genesis of depression. Commentary on Fuchs et al., examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews
    T Steckler
    Behav Pharmacol 15:365-8. 2004
  19. ncbi Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume
    M G C van der Hart
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Mol Psychiatry 7:933-41. 2002
    ....
  20. ncbi The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disorders
    Marja Van Kampen
    Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Stress 5:37-46. 2002
    ....
  21. ncbi Emergent properties of layer 2/3 neurons reflect the collinear arrangement of horizontal connections in tree shrew visual cortex
    Heather J Chisum
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 23:2947-60. 2003
    ..Taken together, these results suggest that horizontal connections play a significant role in shaping the visual responses of layer 2/3 neurons...
  22. ncbi The contribution of vertical and horizontal connections to the receptive field center and surround in V1
    Heather J Chisum
    Department of Neurobiology, Duke University Medical Center, DUMC Box 3209, Durham, NC 27710, USA
    Neural Netw 17:681-93. 2004
    ..By extension, we suggest that the perceptual effects of stimulus context may arise from stimulus interactions within the receptive field center as well as between center and surround...
  23. ncbi Contour integration and segmentation with self-organized lateral connections
    Yoonsuck Choe
    Department of Computer Science, Texas A and M University, College Station, TX 77843, USA
    Biol Cybern 90:75-88. 2004
    ..The model thus grounds an important perceptual phenomenon onto detailed neural mechanisms so that various structural and functional properties can be measured and predictions can be made to guide future experiments...
  24. ncbi Chronic social stress: effects on limbic brain structures
    Eberhard Fuchs
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077, Gottingen, Germany
    Physiol Behav 79:417-27. 2003
    ..The present review summarizes observations made in the tree shrew chronic psychosocial stress paradigm with particular focus on neurotransmitter systems and structural changes in limbic brain regions...
  25. ncbi Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
    Paul J Lucassen
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Biol Psychiatry 55:789-96. 2004
    ..Here, we investigated whether the antidepressant tianeptine would affect apoptosis in an animal model of depression, the psychosocially stressed tree shrew...
  26. ncbi Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters
    Marieke G C van der Hart
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen
    Psychopharmacology (Berl) 181:207-16. 2005
    ....
  27. ncbi Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Psychopharmacology (Berl) 180:548-57. 2005
    ..Substance P antagonists have been proposed as candidates for a new class of antidepressant compounds...
  28. ncbi Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews
    U Meyer
    Division of Neurobiology, German Primate Center,
    Hippocampus 11:329-36. 2001
    ..Moreover, the differential regulation of MR mRNA along the rostrocaudal axis of the hippocampus adds another feature to the heterogenous composition of this structure...
  29. ncbi Areal specialization of pyramidal cell structure in the visual cortex of the tree shrew: a new twist revealed in the evolution of cortical circuitry
    Guy N Elston
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, The University of Queensland, 4072 Queensland, Australia
    Exp Brain Res 163:13-20. 2005
    ..In addition, pyramidal cells in V1 of the tree shrew are more than twice as spinous as those in primates. These data suggest that variables that shape the structure of adult cortical pyramidal cells differ among species...
  30. ncbi The tree shrews: useful animal models for the viral hepatitis and hepatocellular carcinoma
    Er Bin Yang
    Department of Experimental Surgery, Singapore General Hospital, Singapore
    Hepatogastroenterology 52:613-6. 2005
    ..This review focuses on the establishment of human HBV-induced hepatitis and human HBV-associated HCC in tree shrews and their applications in the study of HCC development...
  31. ncbi The visual pulvinar in tree shrews II. Projections of four nuclei to areas of visual cortex
    David C Lyon
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, Tennessee 37203, USA
    J Comp Neurol 467:607-27. 2003
    ..In addition, the cortical injections revealed that the LGN projects topographically and densely to V1 and that a significant number of LGN neurons project to V2 and TD...
  32. ncbi A morphological basis for orientation tuning in primary visual cortex
    Francois Mooser
    Department of Neurobiology, Box 3209 Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 7:872-9. 2004
    ..We conclude that the anisotropic arrangement of axon terminals is the principal source of the orientation bias contributed by feedforward connections...
  33. ncbi Alpha2A and alpha2C-adrenoceptor regulation in the brain: alpha2A changes persist after chronic stress
    G Flugge
    Department of Neurobiology, German Primate Centre, Kellnerweg 4, 37077 Gottingen, Germany
    Eur J Neurosci 17:917-28. 2003
    ..The present findings coincide with post mortem studies in depressed patients revealing upregulation of alpha2A-ARs...
  34. pmc The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery
    John T Siegwart
    Department of Physiological Optics, School of Optometry, 302 Worrell Building, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Invest Ophthalmol Vis Sci 43:2067-75. 2002
    ....
  35. ncbi Dynamic expression of apoptosis-related genes during development of laboratory hepatocellular carcinoma and its relation to apoptosis
    Xiao xian Duan
    Department of Pathology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    World J Gastroenterol 11:4740-4. 2005
    ....
  36. ncbi Luminance-evoked inhibition in primary visual cortex: a transient veto of simultaneous and ongoing response
    Thomas R Tucker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 26:13537-47. 2006
    ..We conclude that cortical inhibition is a critical factor in luminance-evoked cortical suppression and the likely substrate for luminance-induced visual masking phenomenon...
  37. doi Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew
    T Kozicz
    Department of Cellular Animal Physiology, Faculty of Science, IWWR, EURON European Graduate School of Neuroscience, Radboud University Nijmegen, 6525 ED Nijmegen, Toernooiveld 1, The Netherlands
    Psychoneuroendocrinology 33:741-54. 2008
    ....
  38. ncbi First evidence of melatonin receptors distribution in the suprachiasmatic nucleus of tree shrew brain
    Celine Legros
    INRA, UMR85 Physiologie de Reproduction et des Comportements, F 37380 Nouzilly, France
    Neuro Endocrinol Lett 28:267-73. 2007
    ..In this study we investigated the distribution of melatonergic receptors in the tree shrew brain. The psychosocial stress in the tree shrew is a validated model of depression with disturbance of circadian rhythms...
  39. ncbi More questions than answers. Commentary on Fuchs et al., examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews
    K A Miczek
    Behav Pharmacol 15:363-4. 2004
  40. ncbi The visual pulvinar in tree shrews I. Multiple subdivisions revealed through acetylcholinesterase and Cat-301 chemoarchitecture
    David C Lyon
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, Tennessee 37203, USA
    J Comp Neurol 467:593-606. 2003
    ..The complex resembles the pulvinar of primates by having a portion ventral to the brachium and by having histochemically distinct nuclei; the number of nuclei is less than in primates, however...
  41. ncbi Cell culture models and animal models of viral hepatitis. Part II: hepatitis C
    Chandan Guha
    Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Lab Anim (NY) 34:39-47. 2005
    ..The authors review in vitro and in vivo models that are being used to study HCV and to develop new treatments and preventive measures...
  42. ncbi Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system
    Eberhard Fuchs
    Clinical Neurobiology Laboratory, German Primate Center, Göttingen bDepartment of Neurology, Medical School, University of Gottingen
    Int Clin Psychopharmacol 21:S17-20. 2006
    ..Antagonism of 5-HT2c receptors is reported for various established antidepressant compounds. The antidepressant properties of agomelatine are thus based on its melatonergic actions and 5-HT2c receptor antagonism...
  43. ncbi Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews
    Jian Jia Su
    Department of Experimental Pathology, Guangxi Cancer Institute, Nanning 530021, Guangxi Zhuang Autonomous Region, China
    World J Gastroenterol 10:3559-63. 2004
    ..To investigate p53 mutation and p21 expression in hepatocarcinogenesis induced by hepatitis B virus (HBV) and aflatoxin B(1) (AFB(1)) in tree shrews, and to reveal the role of these genes in hepatocarcinogenesis...
  44. ncbi Temporal modulation sensitivity of tree shrew retinal ganglion cells
    Haidong D Lu
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    Vis Neurosci 20:363-72. 2003
    ..These data suggest that two well-separated temporal channels exist at the retinal ganglion cell level in the tree shrew retina, with the transient channel playing a major role in temporal vision...
  45. ncbi Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1
    Patricia A Egner
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 16:1174-80. 2003
    ..Bioassays indicated that the tree shrew was considerably more resistant than the rat to AFB(1) hepatocarcinogenesis, which may reflect the significant differences in metabolic profiles of the two species...
  46. ncbi Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrews
    Yuan Li
    Department of Experimental Pathology, Guangxi Cancer Institute, Nanning 530021, Guangxi Zhuang Autonomous Region, China
    World J Gastroenterol 10:497-504. 2004
    ....
  47. ncbi Gene expression analysis in the hippocampal formation of tree shrews chronically treated with cortisol
    Julieta Alfonso
    Instituto de Investigaciones Biotecnologicas, Instituto Tecnológico de Chascomús CONICET, Universidad Nacional de General San Martin, San Martin, Argentina
    J Neurosci Res 78:702-10. 2004
    ..Finally, a detailed analysis of the genomic localization in human and mouse genomes revealed a survey of putative novel splicing variants for several genes of the nervous system...
  48. ncbi Aging is accompanied by a subfield-specific reduction of serotonergic fibers in the tree shrew hippocampal formation
    Jeanine I H Keuker
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    J Chem Neuroanat 30:221-9. 2005
    ..Our findings also indicate that the rat and the tree shrew hippocampal serotonergic innervation show some variations that seem to be differentially affected during aging...
  49. ncbi Perturbations in brain monoamine systems during stress
    Gabriele Flugge
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077, Gottingen, Germany
    Cell Tissue Res 315:1-14. 2004
    ..Accordingly, stress-induced changes in brain monoamine systems are suspected to contribute to psychiatric diseases such as depression. The present paper gives a short overview of stress effects on brain monoamines and their receptors...
  50. ncbi Jaw-muscle electromyography during chewing in Belanger's treeshrews (Tupaia belangeri)
    Christopher J Vinyard
    Department of Biological Anthropology and Anatomy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Phys Anthropol 127:26-45. 2005
    ....
  51. ncbi Postnatal allometry of the skeleton in Tupaia glis (Scandentia: Tupaiidae) and Galea musteloides (Rodentia: Caviidae)--a test of the three-segment limb hypothesis
    Nadja Schilling
    Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich Schiller Universitat, Erbertstr 1, D 07743 Jena, Germany
    Zoology (Jena) 109:148-63. 2006
    ..Different life histories seem to have a strong influence on postnatal ontogenetic scaling; the effects of the developmental differences are still observable when comparing adults of the two species...
  52. pmc A preliminary analysis of the relationship between jaw-muscle architecture and jaw-muscle electromyography during chewing across primates
    Christopher J Vinyard
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Anat Rec (Hoboken) 293:572-82. 2010
    ..Finally, the contrasting results for the masseter and temporalis suggest that the fiber architecture of these muscles has evolved as distinct functional units in primates...
  53. doi Sarcocystis tupaia, sp. nov., a new parasite species employing treeshrews (Tupaiidae, Tupaia belangeri chinensis) as natural intermediate hosts
    Zheng Xiang
    Parasitology Department, Kunming Medical University, Yunnan, China
    Parasitol Int 59:128-32. 2010
    ..Their genetic and morphological uniformity suggest that these parasites, derived from treeshrews, represent a single biological species, Sarcocystis tupaia, sp. nov...
  54. pmc Shrewd alliances: mixed foraging associations between treeshrews, greater racket-tailed drongos and sparrowhawks on Great Nicobar Island, India
    Meera Anna Oommen
    Centre for Herpetology Madras Crocodile Bank Trust, Post Bag 4, Mamallapuram, Tamil Nadu 603104, India
    Biol Lett 6:304-7. 2010
    ....
  55. ncbi B1 and related SINEs in mammalian genomes
    Nikita S Vassetzky
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St, 119991, Moscow, Russia
    Gene 319:149-60. 2003
    ..This hypothesis allows us to explain short rearrangements in these and other short retroposons...
  56. ncbi [Primary culture and purification of cerebral astrocyte of tree shrew]
    Min Gong
    Department of Pathophysiology, Kunming Medical College, Kunming 650031, China
    Sheng Li Xue Bao 63:89-92. 2011
    ..Thus the method to culture highly purified astrocyte of tree shrew was successfully established, which would contribute to further study in central nervous system physiology and diseases in this new laboratorial animal...
  57. doi Chromosome painting of the pygmy tree shrew shows that no derived cytogenetic traits link primates and scandentia
    F Dumas
    Section Animal Biology and Biological Anthropology G Reverberi, Department of Environment Biology and Biodiversity, University of Palermo, Palermo, Italy
    Cytogenet Genome Res 136:175-9. 2012
    ..Our data remove any cytogenetic evidence that Scandentia has a preferential phylogenetic relationship with Primates...
  58. doi [Expression of epidermal fatty acid-binding protein in cross-species hepatocellular carcinoma]
    Jun Lin Shi
    Department of Experimental Pathology, Tumor Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Gan Zang Bing Za Zhi 20:270-4. 2012
    ..To evaluate the utility of the cross-species screening strategy for investigating key molecule(s) involved in onset and progression of hepatocellular carcinoma (HCC)...
  59. ncbi Evolutionary transformation of the cervicobrachial plexus in the colugo (Cynocephalidae: Dermoptera) with a comparison to treeshrews (Tupaiidae: Scandentia) and strepsirrhines (Strepsirrhini: Primates)
    T Kawashima
    Department of Anatomy, Toho University, Tokyo, Japan
    Folia Morphol (Warsz) 71:228-39. 2012
    ....
  60. doi Does a nonprimate mammal, the northern tree shrew (Tupaia belangeri), exhibit paw preference in two forms of a grasping task?
    Audrey Maille
    University of Rennes 1 and French National Centre for Scientific Research, Paimpont, France
    J Comp Psychol 127:14-23. 2013
    ..This basic motor organization might be a first step in the evolution of manual laterality, which eventually became controlled by vision in the primate lineage...
  61. doi Energy metabolism, thermogenesis and body mass regulation in tree shrew (Tupaia belangeri) during subsequent cold and warm acclimation
    Lin Zhang
    School of Life Sciences, Yunnan Normal University, Kunming 650500, China
    Comp Biochem Physiol A Mol Integr Physiol 162:437-42. 2012
    ..Serum leptin, as a starvation signal in the cold and satiety signal in rewarming, was involved in the processes of thermogenesis and body mass regulation in tree shrews...
  62. pmc Interferon-lambda3 (IFN-λ3) and its cognate receptor subunits in tree shrews (Tupaia belangeri): genomic sequence retrieval, molecular identification and expression analysis
    Ming li Li
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China
    PLoS ONE 8:e60048. 2013
    ....
  63. pmc Link between orientation and retinotopic maps in primary visual cortex
    Se Bum Paik
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:7091-6. 2012
    ..More broadly, it raises the possibility that spatially structured input from the periphery may shape the organization of primary sensory cortex of other modalities as well...
  64. ncbi Molecular anatomy of Tupaia (tree shrew) adenovirus genome; evolution of viral genes and viral phylogeny
    Udo Bahr
    Hygiene Institute, Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Federal Republic of Germany
    Virus Genes 27:29-48. 2003
    ..The Tupaia adenovirus (TAV) infects members of the genus Tupaiidae that are frequently used as laboratory animals in behavior research dealing with questions about biological and ..
  65. ncbi [Long-term observation of hepatitis B virus (HBV) replication in new-born tree shrews inoculated with HBV]
    Fang Yang
    Department of Experimental Pathology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Gan Zang Bing Za Zhi 17:580-4. 2009
    ..To observe the hepatitis B virus (HBV) replication in the tree shrews that were inoculated with HBV at neonatal period...
  66. doi Retinal and choroidal TGF-beta in the tree shrew model of myopia: isoform expression, activation and effects on function
    Andrew Ian Jobling
    Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Melbourne, Victoria, Australia
    Exp Eye Res 88:458-66. 2009
    ..Thus, the regulation of eye growth via the retinoscleral cascade involves more than one factor, which is likely to be tissue-specific in nature...
  67. doi Chronic psychosocial stress alters NPY system: different effects in rat and tree shrew
    E Zambello
    Neurosciences Centre for Excellence in Drug Discovery, Mood and Anxiety Disorders DPU, GlaxoSmithKline Medicines Research Center, Verona, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:122-30. 2010
    ....
  68. ncbi Molecular and genomic data identify the closest living relative of primates
    Jan E Janecka
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 318:792-4. 2007
    ..Our data show that colugos are the closest living relatives of primates and indicate that their divergence occurred in the Cretaceous...
  69. doi A novel approach of prophylaxis to HBV recurrence after liver transplantation
    Tao Pan
    Key Laboratory of Organ Transplantation, Ministry of Education Ministry of Public Health, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Virology 382:1-9. 2008
    ..So, intramuscular injection of rAAV-HB was a suitable method for the immunoprophylaxis of HBV infection. This human antibody will be useful for the immunoprophylaxis of HBV infection...
  70. ncbi Identification of the tree shrew ATP-binding cassette transporter A1 (ABCA1) and its expression in tissues : cDNA sequence and expression of tree shrew ABCA1
    Wu Wei Zeng
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Mol Biol Rep 36:443-8. 2009
    ..This pattern was partially different from that of human ABCA1 which was low in kidney and cardiac muscle. This work could shed new light on its role of ABCA1 in the distinctive HDL metabolism in tree shrew...
  71. pmc A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cells
    Ping Zhang
    Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan Province, China
    Immunology 128:500-10. 2009
    ..Also, a naturally occurring CD1d mutation(s) that confers inability to stimulate iNKT cell function may have implications for future studies on CD1d/iNKT-associated diseases...
  72. doi SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression
    Adina T Michael-Titus
    Neuroscience Centre, Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, UK
    Eur J Pharmacol 598:43-50. 2008
    ....
  73. pmc Mutualism between tree shrews and pitcher plants: perspectives and avenues for future research
    Charles Clarke
    School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Selangor, Malaysia
    Plant Signal Behav 5:1187-9. 2010
    ..Further research into this extraordinary animal-plant interaction is required to gain a better understanding of the benefits to the participating species...
  74. doi Patterns of variation across primates in jaw-muscle electromyography during mastication
    Christopher J Vinyard
    Department of Anatomy and Neurobiology, NEOUCOM, Rootstown, OH, USA Department of Evolutionary Anthropology, Duke University, Durham, NC, USA Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, OH, USA
    Integr Comp Biol 48:294-311. 2008
    ....
  75. doi Relationships between the expression of the stapedial artery and the size of the obturator foramen in euarchontans: Functional and phylogenetic implications
    Mark N Coleman
    Department of Anatomy, Midwestern University, 19555N 59th Ave, Glendale, AZ 85308, USA
    J Hum Evol 60:106-16. 2011
    ..The implications of these findings for auditory function and phylogenetic studies are discussed...
  76. pmc Female-biased dispersal and gene flow in a behaviorally monogamous mammal, the large treeshrew (Tupaia tana)
    Jason Munshi-South
    Behavior, Ecology, Evolution and Systematics Program, Department of Biology, University of Maryland, College Park, Maryland, USA
    PLoS ONE 3:e3228. 2008
    ..The predicted relationship between FBD and monogamy may also be too simplistic, given that many pair-living mammals exhibit substantial extra-pair paternity...
  77. pmc Networks, trees, and treeshrews: assessing support and identifying conflict with multiple loci and a problematic root
    Trina E Roberts
    University of Alaska Museum and Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775, USA
    Syst Biol 58:257-70. 2009
    ..We used 6 presumably unlinked nuclear loci to investigate relationships within the mammalian family Tupaiidae (Scandentia), containing all but one of the extant tupaiid genera...
  78. doi [Detection and comparison of physiological indexes in the wild and laboratory tree shrew]
    Xu Tong Ma
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming Yunnan 650223, China
    Dongwuxue Yanjiu 32:4-10. 2011
    ..These data would be valuable for the development of tree shrew models of human diseases...
  79. pmc Chronic intake of fermented floral nectar by wild treeshrews
    Frank Wiens
    Tierphysiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Proc Natl Acad Sci U S A 105:10426-31. 2008
    ..It is yet unclear to what extent treeshrews benefit from ingested alcohol per se and how they mitigate the risk of continuous high blood alcohol concentrations...
  80. doi Tree shrew models: a chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory
    Jing Wang
    Key Laboratory of Animal Models and Human Disease Mechanisms, the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China
    Dongwuxue Yanjiu 32:24-30. 2011
    ....
  81. doi [Preliminary investigation of viruses to the wild tree shrews (Tupaia belangeri Chinese)]
    Xin Xing Wang
    Institute of Medical Biology, Chinese Academy of Medical Sciences Peking Union Medical College, Kunming Yunnan 650118, China
    Dongwuxue Yanjiu 32:66-9. 2011
    ..Based on these results, we propose that herpes simplex virus, coxsackie virus and cotavirus should be listed as top priority for routine virological monitoring of tree shrews...
  82. doi Relief index of second mandibular molars is a correlate of diet among prosimian primates and other euarchontan mammals
    Doug M Boyer
    Department of Anatomical Sciences, Stony Brook University, Stony Brook, NY 11794 8081, United States
    J Hum Evol 55:1118-37. 2008
    ..Such comparisons are important for developing a more detailed view of primate evolution...
  83. ncbi Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa
    Shu Qing Li
    Department of Pathophysiology, Kunming Medical College, Kunming 650031, China
    Chin Med J (Engl) 120:1529-33. 2007
    ..This study explored the possible effects of GB on PAFR and the mitochondrial respiration of the neuron in the ischemic microenvironment...
  84. ncbi Experimental myopia in tree shrews
    T T Norton
    Department of Physiological Optics, School of Optometry, The Medical Center, University of Alabama, Birmingham 35294
    Ciba Found Symp 155:178-94; discussion 194-9. 1990
    ..Recovery may occur by a slowing of axial expansion while the optical surfaces proceed toward adult values...
  85. ncbi [Human hepatitis B virus infection of tree shrews and Macaca assamensis in vivo]
    Shu Sheng Wang
    Guangxi Anti Epidemic and Health Center, Nanning, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:21-4. 2003
    ..To examine sensitivity of the tree shrews and Macaca assamensis to human hepatitis B virus (HHBV) by serologic methods...
  86. ncbi Gender-specific alterations of cerebral metabolites with aging and cortisol treatment
    T Michaelis
    Biomedizinische NMR Forschungs GmbH am Max Planck Institut für biophysikalische Chemie, 37070 Gottingen, Germany
    J Psychiatr Res 35:231-7. 2001
    ..05). The observed sex differences with age are likely to result from differences in the regulation of stress-related hormones which is further supported by the gender-specific responses to cortisol...
  87. ncbi Effects of cortisol on brain alpha2-adrenoceptors: potential role in stress
    G Flugge
    German Primate Centre, Gottingen, Germany
    Neurosci Biobehav Rev 23:949-56. 1999
    ....
  88. ncbi Subordination stress alters alternative splicing of the Slo gene in tree shrew adrenals
    David P McCobb
    Department of Neurobiology, Cornell University, Ithaca, NY 14853, USA
    Horm Behav 43:180-6. 2003
    ..We hypothesize that chromaffin cell excitability and sympathoadrenal function will be altered, and speculate that this may favor passive coping responses in subordinate males and females...
  89. ncbi Functional morphology of the hindlimb of tupaiids (Mammalia, Scandentia) and its phylogenetic implications
    Eric J Sargis
    Department of Anthropology, City University of New York, New York, New York 10016, USA
    J Morphol 254:149-85. 2002
    ..tupaiines in their hindlimb morphology, which probably reflects the terrestrial ancestry of Tupaiinae (but not Tupaiidae)...
  90. ncbi Social stress in tree shrews: effects on physiology, brain function, and behavior of subordinate individuals
    Eberhard Fuchs
    Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Pharmacol Biochem Behav 73:247-58. 2002
    ..g., retraction of the dendrites of hippocampal pyramidal neurons. Together, these processes are suggested as a cause of behavioral alterations that can be counteracted by antidepressants in this naturalistic social stress model...
  91. ncbi Calretinin immunoreactivity in the prenatally developing olfactory systems of the tree shrew Tupaia belangeri
    Cordula R Malz
    Department of Morphology, Center of Anatomy, School of Medicine, University of Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    Anat Embryol (Berl) 205:83-97. 2002
    ..Transiently, ectopic calretinin immunoreactive receptor cells were observed in the future non-sensory epithelium of the vomeronasal organ...
  92. ncbi MHC class I genes of the tree shrew Tupaia belangeri
    Perris Flügge
    Abteilung Immungenetik, Universitat Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Immunogenetics 53:984-8. 2002
    ....
  93. ncbi Steady state mRNA levels in tree shrew sclera with form-deprivation myopia and during recovery
    J T Siegwart
    Department of Physiological Optics, School of Optometry, 302 Worrell Building, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Invest Ophthalmol Vis Sci 42:1153-9. 2001
    ..Removal of the visual deprivation allows recovery. This study investigated whether these changes are accompanied by changes in steady state mRNA levels in the sclera...
  94. ncbi Scleral remodeling during the development of and recovery from axial myopia in the tree shrew
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 41:3713-9. 2000
    ..Scleral glycosaminoglycan (GAG) synthesis and content as well as scleral dry weight changes were monitored as indicators of remodeling in myopic and recovering tree shrew sclerae...
  95. ncbi Current status of Helicobacter contamination of laboratory mice, rats, gerbils, and house musk shrews in Japan
    K Goto
    Central Institute for Experimental Animals, 1430 Nogawa, Miyamae ku, Kawasakishi, Kanagawa, 216 0001, Japan
    Curr Microbiol 41:161-6. 2000
    ..rodentium, and H. hepaticus/H. rodentium, respectively, and 1/14 gerbils infected with H. hepaticus. The results suggest the prevalence of these species of Helicobacter in mice, rats, gerbils, and house musk shrews in Japan...
  96. ncbi Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1
    U S Park
    Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea
    Gene 251:73-80. 2000
    ..As a result, our finding indicates that tree shrews exposed to AFB1 and/or HBV had neither codon 249 mutations nor significant levels of other mutations in the p53 gene, as is the case with humans...
  97. ncbi Experimental therapy of a platelet-activating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews
    S Li
    Department of Pathophysiology, Kunming Medical College, China
    Clin Exp Pharmacol Physiol 26:824-5. 1999
    ....
  98. ncbi Localization of dopamine receptors in the tree shrew brain using [3H]-SCH23390 and [125I]-epidepride
    M J Mijnster
    German Primate Center, Gottingen
    Brain Res 841:101-13. 1999
    ..Overall, the evidence coincides with the view that tree shrews are phylogenetically related to primates...
  99. ncbi Beta-adrenoceptors in the tree shrew brain. II. Time-dependent effects of chronic psychosocial stress on [125I]iodocyanopindolol bindings sites
    G Flugge
    German Primate Center, Gottingen, Germany
    Cell Mol Neurobiol 17:417-32. 1997
    ..These mechanisms may be important components of the regulatory apparatus which enables the individual to adapt to situations of recurrent stressful experiences by balancing the central nervous adrenoceptor number...
  100. ncbi Protection of tree shrews by pVAX-PS DNA vaccine against HBV infection
    Feng Juan Zhou
    Department of Medical Genetics, The Second Military Medical University, Shanghai, China
    DNA Cell Biol 22:475-8. 2003
    ..These results indicated that pVAX-PS immunization could induce remarkable humoral immune response and prevent the experimental tree shrews from infection of HBV...
  101. ncbi [Differentially expressed genes in hepatocellular carcinoma of tree shrew induced by different factors]
    Yuan Li
    Department of Experimental Pathology, Guangxi Cancer Institute, Nanning, Guangxi, 530021, PR China
    Ai Zheng 22:1018-22. 2003
    ....

Research Grants42

  1. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
    ..This application will identify genes and gene products that control the axial length of the eye as a step toward finding ways to prevent or minimize myopia in children. ..
  2. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2006
    ..Understanding the mechanisms regulating scleral remodeling may point the way toward targets for drug intervention to one-day control myopia progression. ..
  3. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
    ..This application will identify genes and gene products that control the axial length of the eye as a step toward finding ways to prevent or minimize myopia in children. ..
  4. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2007
    ..It may also lead to successful optical or pharmacological interventions to slow or prevent myopia. Project Description Page 6 ..
  5. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2009
    ..This application will identify genes and gene products that control the axial length of the eye as a step toward finding ways to prevent or minimize myopia in children. ..
  6. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2010
    ..This application will identify genes and gene products that control the axial length of the eye as a step toward finding ways to prevent or minimize myopia in children. ..
  7. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2001
    ..This, in turn, will help us to learn how human eyes normally control their elongation, and how interactions with the visual environment can lead to myopia (nearsightedness) in children. ..
  8. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 1993
    ..If we can learn the mechanisms that produce emmetropia and ametropia in tree shrews, a species closely related to primates, it will then be reasonable to ask whether similar mechanisms control ocular development in humans...
  9. The role of short-range horizontal connections in cortical computation
    STEPHEN VAN HOOSER; Fiscal Year: 2007
    ....
  10. Information Transfer from LGN to Primary Visual Cortex
    STEPHEN VAN HOOSER; Fiscal Year: 2004
    ....
  11. MSM--Multiscale Imaging, Analysis, and Integration of Brain Networks
    Yoonsuck Choe; Fiscal Year: 2007
    ..Data from this project will be made public, along with the software for its integrative storage, retrieval, and analysis. ..
  12. REGULATION OF CELLULAR EXCITABILITY BY STRESS HORMONES
    DAVID MC COBB; Fiscal Year: 2003
    ..Thus, the goal is to elucidate molecular mechanisms by which stress experiences, life stages, and genes adapt and/or limit the mechanisms of catecholamine secretion. ..