nude mice


Summary: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

Top Publications

  1. ncbi Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
    Qian Zhang
    Genelux Corporation, San Diego Science Center, San Diego, California 92109, USA
    Cancer Res 67:10038-46. 2007
  2. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
  3. ncbi Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    Akira Nakamizo
    Department of Neurosurgery, Brain Tumor Center, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3307-18. 2005
  4. ncbi A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro
    T Yoneda
    Department of Medicine, The University of Texas Health Science Center at San Antonio, 78229-3900, USA
    J Bone Miner Res 16:1486-95. 2001
  5. ncbi Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:4758-65. 2006
  6. pmc New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    J Tian
    Liver Cancer Institute and Zhong Shan Hospital, Shanghai Medical University, Peoples Republic of China
    Br J Cancer 81:814-21. 1999
  7. ncbi Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 422:313-7. 2003
  8. ncbi Malignant transformation in a nontumorigenic human prostatic epithelial cell line
    S W Hayward
    Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
    Cancer Res 61:8135-42. 2001
  9. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
  10. ncbi Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice
    Chin Hsien Tsai
    Agricultural Biotechnology Research Center, Academia Sinica, Nankang, Taipei, Taiwan
    Clin Cancer Res 15:5435-44. 2009

Detail Information

Publications377 found, 100 shown here

  1. ncbi Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
    Qian Zhang
    Genelux Corporation, San Diego Science Center, San Diego, California 92109, USA
    Cancer Res 67:10038-46. 2007
    ..I.v. injections of GLV-1h68 (1x10(7) plaque-forming unit per mouse) into nude mice with established (approximately 300-500 mm3) s.c...
  2. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  3. ncbi Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    Akira Nakamizo
    Department of Neurosurgery, Brain Tumor Center, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3307-18. 2005
  4. ncbi A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro
    T Yoneda
    Department of Medicine, The University of Texas Health Science Center at San Antonio, 78229-3900, USA
    J Bone Miner Res 16:1486-95. 2001
    ..MDA-231BR) clones of the human breast cancer cell line MDA-MB-231 by repeated sequential passages in nude mice and in vitro of metastatic cells obtained from bone and brain metastases, respectively...
  5. ncbi Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:4758-65. 2006
    ..Treatment of PC-3 tumor-bearing nude mice with Celastrol (1-3 mg/kg/d, i.p., 1-31 days) resulted in significant inhibition (65-93%) of the tumor growth...
  6. pmc New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    J Tian
    Liver Cancer Institute and Zhong Shan Hospital, Shanghai Medical University, Peoples Republic of China
    Br J Cancer 81:814-21. 1999
    ..a highly metastatic potential was established from subcutaneous xenograft of a metastatic model of human HCC in nude mice (LCI-D20) by means of alternating cell culture in vitro and growth in nude mice...
  7. ncbi Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 422:313-7. 2003
    ..This requirement for Hh pathway activation identifies a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway...
  8. ncbi Malignant transformation in a nontumorigenic human prostatic epithelial cell line
    S W Hayward
    Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
    Cancer Res 61:8135-42. 2001
    The human prostatic epithelial cell line BPH-1 is normally nontumorigenic in nude mice. The present report demonstrates that this cell line can be permanently transformed by its microenvironment to become tumorigenic...
  9. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  10. ncbi Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice
    Chin Hsien Tsai
    Agricultural Biotechnology Research Center, Academia Sinica, Nankang, Taipei, Taiwan
    Clin Cancer Res 15:5435-44. 2009
    ..Inflammation is involved in promoting tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer...
  11. ncbi Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system
    Kensuke Yamauchi
    AntiCancer, Inc, San Diego, California 92111, USA
    Cancer Res 66:4208-14. 2006
    ..Dual-color cancer cells were injected by a vascular route in an abdominal skin flap in nude mice. The mice were imaged with an Olympus OV100 whole-mouse imaging system with a sensitive CCD camera and five ..
  12. ncbi Cancer and the chemokine network
    Fran Balkwill
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Cancer 4:540-50. 2004
  13. ncbi Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo
    Bakhos A Tannous
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Ther 11:435-43. 2005
  14. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
  15. ncbi Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 66:6699-707. 2006
    ..Moreover, the possibility that the pH(e) of the primary tumor may be an important prognostic parameter for melanoma patients merits clinical investigation...
  16. ncbi CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    Dagmar Beier
    Laboratory of Neurooncology, University of Regensburg, Regensburg, Germany
    Cancer Res 67:4010-5. 2007
    ..Both subtypes were similarly tumorigenic in nude mice in vivo...
  17. ncbi A decade's studies on metastasis of hepatocellular carcinoma
    Zhao You Tang
    Liver Cancer Institute, Zhongshan Hospital, 136 Yi Xue Yuan Road, 200032, Shanghai, PR China
    J Cancer Res Clin Oncol 130:187-96. 2004
    ..We have established a stepwise metastatic human HCC model system, which included a metastatic HCC model in nude mice (LCI-D20), a HCC cell line with high metastatic potential (MHCC97), a relatively low metastatic potential cell ..
  18. ncbi A paracrine requirement for hedgehog signalling in cancer
    Robert L Yauch
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 455:406-10. 2008
    ..Taken together, these studies demonstrate a paracrine requirement for Hh ligand signalling in the tumorigenesis of Hh-expressing cancers and have important implications for the development of Hh pathway antagonists in cancer...
  19. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
    ..Angiogenesis and blood-island formation were impaired, resulting in several developmental anomalies. Furthermore, VEGF-null embryonic stem cells exhibit a dramatically reduced ability to form tumours in nude mice.
  20. ncbi Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    Katharina Aschenbrenner
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 8:351-8. 2007
    ..Thus, 'routing' of mTEC-derived self antigens may determine whether specific thymocytes are deleted or enter the regulatory T cell lineage...
  21. ncbi PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    Adrienne Boire
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Cell 120:303-13. 2005
    ..These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion...
  22. ncbi Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent
    I Gentschev
    Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA
    Cancer Gene Ther 16:320-8. 2009
    ..systemic administration this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice. The efficient tumor colonization process resulted in inhibition of tumor growth and drastic reduction of tumor ..
  23. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  24. ncbi Stat3 as an oncogene
    J F Bromberg
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Cell 98:295-303. 1999
    ..fibroblasts causes cellular transformation scored by colony formation in soft agar and tumor formation in nude mice. Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus ..
  25. pmc A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice
    Naghma Khan
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 68:8555-63. 2008
    ..Fisetin also synergized with Casodex in inducing apoptosis in LNCaP cells. Treatment with fisetin in athymic nude mice implanted with AR-positive CWR22Rupsilon1 human PCa cells resulted in inhibition of tumor growth and reduction ..
  26. ncbi CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells
    Z Qin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Immunity 12:677-86. 2000
    ..This shows that an effective anti-tumor response involves communication between CD4+ T cells and nonhematopoietic cells, most likely within the tumor stroma, and that tumor immunity must not entirely rely on direct tumor cell killing...
  27. ncbi Sentinel lymph node imaging using quantum dots in mouse tumor models
    Byron Ballou
    Molecular Biosensor and Imaging Center, Department of Biological Sciences, and Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Bioconjug Chem 18:389-96. 2007
    ..Examination of the sentinel nodes identified by quantum dot localization showed that at least some contained metastatic tumor foci...
  28. pmc Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68
    Yong A Yu
    Genelux Corporation, San Diego Science Center, 3030 Bunker Hill Street, Suite 310, San Diego, CA 92109, USA
    Mol Cancer Ther 8:141-51. 2009
    ..of a replication-competent vaccinia virus, GLV-1h68, against human pancreatic carcinomas in cell cultures and in nude mice. We found that GLV-1h68 was able to infect, replicate in, and lyse tumor cells in vitro...
  29. ncbi BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    Scott M Wilhelm
    Bayer Pharmaceuticals Corporation, West Haven, Connecticut 06516, USA
    Cancer Res 64:7099-109. 2004
    ..These data demonstrate that BAY 43-9006 is a novel dual action RAF kinase and VEGFR inhibitor that targets tumor cell proliferation and tumor angiogenesis...
  30. ncbi The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  31. ncbi Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    Yu Wang
    Genome Research Center, University of Hong Kong, China
    Cancer Res 66:11462-70. 2006
    ..overexpression of this adipokine substantially reduced the mammary tumorigenesis of MDA-MB-231 cells in female nude mice. Taken together, these data support the role of adiponectin as a negative regulator of breast cancer development ..
  32. ncbi Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    M Skobe
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 7:192-8. 2001
    ..occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice. Vascular endothelial growth factor (VEGF)-C overexpression in breast cancer cells potently increased ..
  33. ncbi Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Cancer Cell 7:561-73. 2005
    ..Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells. These data have important implications for therapy of cancers harboring PIK3CA alterations...
  34. pmc Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites
    María Virtudes Céspedes
    Grup d Oncogenesi i Antitumorals, Institut de Recerca, Barcelona, Spain
    Am J Pathol 170:1077-85. 2007
    ..whether direct orthotopic cell microinjection, between the mucosa and the muscularis layers of the cecal wall of nude mice, drives tumor foci to the most relevant metastatic sites observed in humans and/or improves its yield as ..
  35. ncbi Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice
    David H Ho
    Department of Surgery and Physiology and the University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 64:8968-72. 2004
    ..This result suggests that the TWEAK-Fn14 signaling system may be a potential regulator of human tumorigenesis...
  36. ncbi Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice
    E Tartour
    Unité d Immunologie Clinique, INSERM U 225 and Université Pierre et Marie Curie, Paris, France
    Cancer Res 59:3698-704. 1999
    ..IL-17 exhibited a significant increase in tumor size as compared to the parent tumor when transplanted in nude mice. This enhanced tumor growth elicited by IL-17 was associated with increased expression of IL-6 and macrophage ..
  37. pmc Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression
    Marianela Candolfi
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    J Neurooncol 85:133-48. 2007
    ..Importantly, our results indicate that dog GBM emerges as an attractive animal model for testing novel therapies in a spontaneous tumor in the context of a larger brain...
  38. pmc Regression of human prostate tumors and metastases in nude mice following treatment with the recombinant oncolytic vaccinia virus GLV-1h68
    Ivaylo Gentschev
    Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA
    J Biomed Biotechnol 2010:489759. 2010
    ..Our data documented that the GLV-1h68 virus has a great potential for treatment of human prostate carcinoma...
  39. ncbi Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice
    Roni Haklai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    Cancer Chemother Pharmacol 61:89-96. 2008
  40. ncbi Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    F M Sirotnak
    Department of Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 6:4885-92. 2000
    ..They also suggest significant clinical benefit from ZD1839 in combination with a variety of widely used cytotoxic agents...
  41. ncbi Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice
    In Young Kim
    College of Pharmacy, Sookmyung Women s University Chungpa Dong 2 Ga, Yongsan gu, Seoul, 140 742, Republic of Korea
    J Control Release 140:55-60. 2009
    ..These results demonstrate that PSLs provide an efficient and targeted delivery of gemcitabine and may represent a useful new treatment approach for tumors which overexpress the EGFR...
  42. pmc Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
    Christoph Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg Hospital, Oberdürrbacher Str, 6, D 97080 Wurzburg, Germany
    BMC Cancer 8:122. 2008
  43. ncbi Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling
    Kwan Man
    Department of Surgery, The University of Hong Kong, Hong Kong, People s Republic of China
    Clin Cancer Res 16:967-77. 2010
    ..We aimed to investigate the effects of adiponectin on liver cancer growth and metastasis and explore the underlying mechanisms...
  44. ncbi Systemic tumor suppression by the proapoptotic gene bik
    Yiyu Zou
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:8-12. 2002
    ..significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer ..
  45. pmc Sonic hedgehog promotes desmoplasia in pancreatic cancer
    Jennifer M Bailey
    Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198, USA
    Clin Cancer Res 14:5995-6004. 2008
    ..We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression...
  46. pmc Gelatin in situ zymography on fixed, paraffin-embedded tissue: zinc and ethanol fixation preserve enzyme activity
    Elin Hadler-Olsen
    Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Histochem Cytochem 58:29-39. 2010
    ..The yield, as analyzed by SDS-PAGE gelatin zymography and Western blotting, was influenced by the composition of the extraction buffer, but was generally lower than that obtained from unfixed tissue...
  47. pmc Engineered measles virus as a novel oncolytic therapy against prostate cancer
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Prostate 69:82-91. 2009
    ..In this study, we investigated the antitumor potential of recombinant MV-Edm derivatives as novel oncolytic agents against prostate cancer...
  48. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  49. ncbi Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation
    Xianping Shi
    Department of Pathophysiology, Zhongshan School of Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Clin Cancer Res 15:1686-97. 2009
    ..In the present study, we investigated the effect of triptolide on cell survival or apoptosis in CML cells bearing Bcr-Abl-T315I or wild-type Bcr-Abl...
  50. ncbi Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..tumor growth and angiogenesis in two animal models of breast cancer: an inflammatory breast cancer xenograft in nude mice and Her2/neu cancer-prone transgenic mice...
  51. ncbi Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
    Yulun Huang
    Department of Neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou, China
    Cancer Lett 264:101-6. 2008
    ..These findings suggest that celastrol have potential to be used as an antiangiogenesis drug through its role in suppressing VEGF receptors expression that might consequently reduce the signal transduction between VEGF and VEGFR...
  52. ncbi Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice
    Guan yu Wang
    Department of Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Asian Nat Prod Res 11:219-28. 2009
  53. pmc Tumor suppressor activity of profilin requires a functional actin binding site
    Nina Wittenmayer
    Cell Biology, Zoological Institute, Technical University of Braunschweig, D 38092 Braunschweig, Germany
    Mol Biol Cell 15:1600-8. 2004
    ..Starting with CAL51, a human breast cancer cell line highly tumorigenic in nude mice, we established stable clones that express PFN1 mutants differentially defective in ligand binding...
  54. ncbi Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development
    L R Kelland
    Antisoma Research Laboratories, St Georges Hospital Medical School, Cranmer Terrace, London SW17 OQS, UK
    Eur J Cancer 40:827-36. 2004
    ..g. inhibitors of the metastatic process and anti-angiogenic strategies as the vasculature is of murine origin)...
  55. ncbi Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice
    Jessica A Manuel
    Regenerative Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Matrix Biol 25:505-14. 2006
    ..We previously found that athymic nude mice are exceptional among mature mammals in their ability to heal injured skin scarlessly...
  56. ncbi Hair growth pattern in nude mice
    K Militzer
    Central Animal Laboratory, University Clinics, Essen, Germany
    Cells Tissues Organs 168:285-94. 2001
    b>Nude mice are not bald but instead show an 'abortive' reduced hair growth on different sites of the integument...
  57. pmc Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
    Elyssa M Rubin
    Department of Oncology, Children s Hospital of Orange County, Orange, California, USA
    Mol Cancer Ther 9:731-41. 2010
    ..WIF-1 overexpression significantly decreased tumor growth rate in nude mice as examined by the s.c. injection of 143B cells stably transfected with WIF-1 and vector control...
  58. pmc Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    S Tanaka
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Clin Invest 103:341-5. 1999
    ..HCC cells promotes the rapid development of human hepatomas and produces hemorrhage within tumors in nude mice. These results suggest a role for Ang2 in the neovascularization of HCC...
  59. pmc Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
    Yang Meng
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 4424E Med Sci I SPC5637, 1301 Catherine Street, Ann Arbor, MI 48109 5637, USA
    Mol Cancer Ther 7:2192-202. 2008
    ..Gossypol significantly enhances the antitumor activity of chemotherapy in vitro and in vivo, representing a promising new regime for the treatment of human hormone-refractory prostate cancer with Bcl-2/Bcl-xL/Mcl-1 overexpression...
  60. ncbi GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice
    Ming Hsien Tsai
    Graduate Institute of Medicine, Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Anticancer Res 30:3291-4. 2010
    Melanoma cell lines that stably express green fluorescent protein (GFP) and nude mice that ubiquitously express red fluorescent protein (RFP) have previously been developed to study tumor-host interaction by color-coded imaging...
  61. ncbi A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice
    Sung Dong Lee
    Department of Food and Nutrition, College of Health Science, Korea University, Seoul, Republic of Korea
    J Med Food 13:1-5. 2010
    ..mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered...
  62. ncbi Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice
    Birgit Pfost
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1700-8. 2009
  63. pmc Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice
    Ke Qi Han
    Department of Nuclear Medicine, Ren Ji Hospital, Shanghai Jiaotong University, Dongfang Road 1630, Shanghai 200127, China
    World J Gastroenterol 13:3374-9. 2007
    To investigate anti-tumor activities and apoptosis-regulated mechanisms of bufalin in the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice.
  64. pmc Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    A Krtolica
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 98:12072-7. 2001
    ..Our findings suggest that, although cellular senescence suppresses tumorigenesis early in life, it may promote cancer in aged organisms, suggesting it is an example of evolutionary antagonistic pleiotropy...
  65. pmc Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo
    Shu Fu Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Endocrinol Metab 93:4403-7. 2008
    ..Anaplastic thyroid carcinoma (ATC) is a fatal disease with a median survival of only 6 months. Novel therapies are needed to improve dismal outcomes...
  66. ncbi Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes
    J A McCart
    Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892-1502, USA
    Cancer Res 61:8751-7. 2001
    ..Eight days after nude mice were injected i.p...
  67. pmc Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228. 2008
    ..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
  68. ncbi Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    F Ciardiello
    Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy
    Clin Cancer Res 7:1459-65. 2001
  69. ncbi Effect of arsenic trioxide on human hepatocarcinoma in nude mice
    Hong Yu Xu
    Department of Gastroenterology, The First Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    World J Gastroenterol 10:3677-9. 2004
    ..To study the effect of arsenic trioxide (As(2)0(3)) on human hepatoma cell line BEL-7402 in vivo...
  70. ncbi Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 64:4201-8. 2004
    ..We tested this hypothesis in nude mice, using human PC-3MM2 prostate cancer cells...
  71. ncbi Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer
    Carolyn Cao
    Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 66:11409-15. 2006
    ..When similar combination was applied to the H460 lung cancer xenograft model in nude mice, loss of radiation-induced phosphorylated Flk-1 was observed in the combination treatment group, which also ..
  72. ncbi Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice
    Bokyung Sung
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 69:1477-84. 2009
    ..that zerumbone decreased osteolysis in a dose-dependent manner in MDA-MB-231 breast cancer tumor-bearing athymic nude mice. These results indicate that zerumbone is an effective blocker of RANKL-induced NF-kappaB activation and of ..
  73. ncbi EphB4 provides survival advantage to squamous cell carcinoma of the head and neck
    Rizwan Masood
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 119:1236-48. 2006
    ..Expression of EphB4 in HNSCC tumor cells confers survival and invasive properties, and thereby provides a strong rationale for targeting EphB4 as novel therapy for HNSCC...
  74. pmc Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents
    C R Ireson
    1Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College, St Mary s Hospital, London W2 1NY, UK
    Br J Cancer 90:932-7. 2004
    ..Their ability to inhibit tumour growth was compared in nude mice bearing xenografts derived from MDA-MB-435 (oestrogen receptor negative) melanoma cancer cells...
  75. ncbi Functional significance of Wnt inhibitory factor-1 gene in kidney cancer
    Kazumori Kawakami
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Cancer Res 69:8603-10. 2009
    ..In conclusion, this is the first report documenting that the WIF-1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells...
  76. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  77. pmc Effects of transplantation of adipose tissue-derived stem cells on prostate tumor
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Prostate 70:1066-73. 2010
    ..Obesity is a risk factor for prostate cancer development, but the underlying mechanism is unknown. The present study tested the hypothesis that stromal cells of the adipose tissue might be recruited by cancer cells to help tumor growth...
  78. ncbi Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers
    Chouhei Sakakura
    Surgery and Regenerative Medicine, Kyoto Prefectural University of Medicine, Japan
    Clin Cancer Res 11:6479-88. 2005
    ..Changes in metastatic potential were assessed in animal experiments using stable RUNX3 transfectants of gastric cancer cells. Finally, global expression changes were analyzed using a cDNA microarray...
  79. ncbi Biological characteristics of fluorescent protein-expressing human hepatocellular carcinoma xenograft model in nude mice
    Bi Wei Yang
    Liver Cancer Institute and Zhongshan Hospital of Fudan University, Shanghai, PR China
    Eur J Gastroenterol Hepatol 20:1077-84. 2008
    To study biological characteristics of stable red fluorescent protein (RFP)-expressing or green fluorescent protein (GFP)-expressing HCCLM3 cell lines and those of their relevant xenograft models in nude mice.
  80. ncbi Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
    C Sgadari
    Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 87:3877-82. 1996
    ..These results document the important role of IP-10 as a mediator of angiogenesis inhibition by IL-12, and raise the possibility that IP-10 may also contribute to the antitumor effect of IL-12...
  81. ncbi Interferon-alphaCon1 suppresses proliferation of liver cancer cell lines in vitro and in vivo
    Toru Hisaka
    Department of Pathology, Kurume University School of Medicine, Research Center of Innovative Cancer Therapy of the 21 Century COE Program for Medical Science, Kurume University, 67 Asahi Machi, 830 0011 Kurume, Japan
    J Hepatol 41:782-9. 2004
    ..We investigated the effects of consensus interferon (IFN-alphaCon1), a nonnaturally occurring type I interferon with higher specific activity than other type I IFNs, on the growth of human liver cancer cells...
  82. ncbi A human prostatic epithelial model of hormonal carcinogenesis
    Y Wang
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    Cancer Res 61:6064-72. 2001
    ..In addition, the data demonstrate that the stromal environment plays an important role in mediating hormonal carcinogenesis...
  83. ncbi A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium
    M Miyagiwa
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    In Vitro Cell Dev Biol 25:503-10. 1989
    ..The HuCC-T1 cell was tumorigenic in nude mice. The number of chromosomes in HuCC-T1 ranged from 61 to 80...
  84. ncbi Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies
    Guido Bocci
    Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 64:6616-25. 2004
    ..magnitude were observed after single injections of DC101 in non-tumor-bearing severe combined immunodeficient or nude mice; similar increases in human plasma VEGF were detected in human tumor-bearing mice...
  85. ncbi Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice
    Christina Schütze
    OncoRay Center for Radiation Research in Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:311-5. 2007
    ..To investigate whether heterogeneity in [(18)F]2-fluoro-2-deoxy-d-glucose (FDG) uptake in a single tumour line, i.e. in tumours with identical genetic background, relates to radiation response...
  86. ncbi Proteasome inhibitors: a novel class of potent and effective antitumor agents
    J Adams
    ProScript, Inc, Cambridge, Massachusetts 02139, USA
    Cancer Res 59:2615-22. 1999
    ..Together, the results highlight that the proteasome is a novel biochemical target and that inhibitors such as PS-341 represent a unique class of antitumor agents. PS-341 is currently under clinical evaluation for advanced cancers...
  87. pmc Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    Yoshiko Minakuchi
    Formulation Research Laboratories, Sumitomo Pharmaceuticals Co Ltd, Osaka 567 0878, Japan
    Nucleic Acids Res 32:e109. 2004
    ..Thus, for clinical applications of siRNA, an Atelocollagen-based non-viral delivery method could be a reliable approach to achieve maximal function of siRNA in vivo...
  88. ncbi Wnt inhibitory factor inhibits lung cancer cell growth
    Jae Kim
    Thoracic Oncology Laboratory, UCSF Comprehensive Cancer Center, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 133:733-7. 2007
    ..Wnt inhibitory factor, a secreted Wnt antagonist, is downregulated in non-small cell lung cancer. We hypothesized that restoration of Wnt inhibitory factor function would inhibit lung cancer cell growth...
  89. pmc In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides
    Kees Fluiter
    Department of Neurogenetics, Academical Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 31:953-62. 2003
    ..Full LNA PO ODNs were continuously administered for 14 days to tumor-bearing nude mice. Tumor growth was inhibited sequence specifically at dosages from 1 mg/kg/day...
  90. pmc Antiproliferative effect of methyl-beta-cyclodextrin in vitro and in human tumour xenografted athymic nude mice
    P Y Grosse
    Department of Oncological Pharmacology, Pharmacy Service, Val d Aurelle Anticancer Center, Montpellier, France
    Br J Cancer 78:1165-9. 1998
    ..In vivo studies were carried out using xenografted Swiss nude mice injected weekly i.p. with MEBCD at 300 or 800 mg kg(-1) or DOX at 2 mg kg(-1), during 2 months...
  91. ncbi Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice
    Alfia Khaibullina
    Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 49:295-302. 2008
    ..The aim of this study was to determine if pulsed high-intensity focused ultrasound (HIFU) exposures could enhance tumor uptake of (111)In-MX-B3, a murine IgG1kappa monoclonal antibody directed against the Le(y) antigen...
  92. ncbi The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    Martine Deckers
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 66:2202-9. 2006
    ..that knockdown of Smad4 in MDA-MB-231 breast cancer cells strongly inhibited the frequency of bone metastasis in nude mice by 75% and significantly increased metastasis-free survival...
  93. ncbi Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0310, Norway
    Eur J Cancer 40:1593-8. 2004
    ..from 12 well-described and generally available colorectal cancer cell lines were implanted in the caecum of nude mice and tumour growth and metastatic events registered...
  94. pmc The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
    C C Blackburn
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Proc Natl Acad Sci U S A 93:5742-6. 1996
    ..The thymic epithelial rudiment of nude mice strongly expressed these same markers, which may therefore define committed immature thymic epithelial precursor ..
  95. pmc An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2725-35. 2008
  96. pmc Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    Beverly L Falcon
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Pathol 175:2159-70. 2009
    ..These findings are consistent with a model whereby inhibition of Ang2 leads to normalization of tumor blood vessels by permitting the unopposed action of Ang1, but decreases tumor vascularity primarily by blocking Ang2 actions...
  97. ncbi 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
    Gregory Maschek
    Department of Cell Biology and Anatomy, University of Miami, School of Medicine, Miami, Florida 33101, USA
    Cancer Res 64:31-4. 2004
    ..b>Nude mice implanted with osteosarcoma cells were divided into four groups as follows: (a) untreated controls; (b) mice ..
  98. ncbi Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray
    Y Li
    Liver Cancer Institute and Zhong Shan Hospital of Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, China
    J Cancer Res Clin Oncol 129:43-51. 2003
    To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms.
  99. ncbi Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice
    Lee Su Kim
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Exp Metastasis 21:107-18. 2004
    ..of breast cancer brain metastases, using intra-internal carotid artery injection of breast cancer cells into nude mice. Brain metastasis-selected variant cells were recovered after three cycles of injection into the internal ..
  100. ncbi Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
    Rihab Nasr
    Université de Paris 7 CNRS UMR 7151, Equipe labellisée N degrees 11 Ligue Nationale Contre le Cancer, Service de Biochimie, Hopital St Louis, Paris Cedex 10, France
    Nat Med 14:1333-42. 2008
    ..Therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells...
  101. pmc The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice
    Yingying Liu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Cancer Res 6:1215-24. 2008
    ..This makes it an attractive candidate for drug therapy for different types of cancer...

Research Grants77

  1. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..cell lines, and the parental cell lines, will be grown as tumors in the cervical subcutaneous tissue of athymic nude mice. The efficacy of curcumin administered in the diet alone or in combination with ionizing radiation on orthotopic ..
  2. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..via cell injection of CD24+, CD24-, or CD34+, or combined with adipose tissue macrophages into non-exposed nude mice. We finally study if PM2...
  3. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Antagonizing UBC9 function in MCF-7 breast cancer cells transplanted in nude mice inhibited cell growth and increased apoptosis via Bcl-2 dependent mechanisms...
  4. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..These results will identify new approaches and targets for preventing sporadic colorectal cancer. ..
  5. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..whether genistein mediated activation of miRNAs can inhibit growth and proliferation of kidney tumors in nude mice. Kidney cancer cells will be injected sub-cutaneously (xenograft) or orthotopically (kidney) into nude mice ..
  6. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..Furthermore, PGG significantly inhibited the in vivo growth of human DU145 PCa xenografts in nude mice without adverse effect on body weight...
  7. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    ..mRNA, protein) and cell proliferation in normal prostate tissue and in PC-3 or DU-145 cell xenografts in nude mice. The studies should define the mechanism of action of L, BMHPC and ZN-2 in the regulation of histone function, ..
  8. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..Studies will be conducted in athymic nude mice implanted with androgen-responsive LNCaP and androgen nonresponsive DuPro prostate cancer cells...
  9. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..these studies is to test this hypothesis in primary human VS cell cultures and human VS xenografts implanted in nude mice. The first aim is to determine whether merlin inhibits JNK activity in human VS cells and in SCs and identify ..
  10. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..suppressed the growth of human lung tumor xenografts by >70% and prolonged the survival of tumor-bearing nude mice without causing detectable toxicity...
  11. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..Finally, we progress to a live animal model (human skin with induced lesions grafted on nude mice), where we will also measure blood flow and local tissue oxygenation as likely markers of aggressive metabolism...
  12. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..In the future, these results may provide better strategies for the management of prostate cancer. ..
  13. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..intracranial tumor growth or invasiveness of human medulloblastoma cell lines injected intracerebrally in nude mice. Specific Aim 2...
  14. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..Studies with HCC cells in culture have shown that miR-122 functions as a tumor suppressor in vitro and in nude mice. To understand the biological functions of miR-122, especially in hepatocarcinogenesis, we have generated ..
  15. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..We will use nude mice subjected to chronic social stress and assess the impact of this condition on cancer prevention by daily ..
  16. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    ..tumor implant model of tumor growth and angiogenesis prior to performance of nanoparticle-targeted treatments of nude mice. The CAM model permits in ova pre-screening for bioactivity while limiting the use of more sentient and costly ..
  17. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    ..Prevention and/or elimination of chronic liver disease will reduce the risk of HBV carriers developing cirrhosis and liver cancer, thereby contributing centrally to improving public health. ..
  18. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
    ..The results obtained will then be further validated by extending this model to nude mice fed a diet supplemented with Se-methylselenocysteine or 1,4- phenylene-bis(methylene)selenocyanate...
  19. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..The most active agent, thus identified, can be further developed for preclinical and clinical testing to prevent progression of early-stage androgen-dependent PCa to CRPCa. ..
  20. SFRP2 and NFAT are therapeutic targets in angiosarcoma
    NANCY K DEMORE; Fiscal Year: 2013 formation in vitro, and systemic administration inhibits the growth of the SVR angiosarcoma xenograft in nude mice by 46% at 20 days...
  21. Targeting ATAP-mediated Apoptosis in Treatment of Prostate Cancer
    Zelin Sheng; Fiscal Year: 2013
    ..Preliminary studies with intravenous injection of ATAP-iRGD into xenograft nude mice with human cancer cells could reduce tumors size while not producing significant off-target toxicity...
  22. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..Treatment with TCN potently inhibits growth in nude mice of human cancer cells that over-express AKT...
  23. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    ..the influence of these botanicals on tamoxifen stimulated endometrial tumor growth in ovariectomized athymic nude mice, an established endometrial cancer model for studying estrogenic influences...
  24. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..Through these studies, I will acquire state-of-the-art knowledge and skills toward my goal to become an established dentist- scientist. ..
  25. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2013
    ..the response to chemotherapeutic agent treatment in pre-neoplastic and neoplastic ovarian cell lines, tumors in nude mice and in malignant human ascites. Define the role o estrogen receptors in SPF45-mediated drug resistance...
  26. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..Laboratory studies show that metformin markedly inhibits growth of human pancreatic cancer cells xenografted in nude mice. This preclinical work is supported by clinical cohort studies showing that metformin users have a reduced risk ..
  27. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..This proposal is designed to generate the pre-clinical efficacy data for the corresponding therapeutic I-131-MIP-1072 in order to assess the possibilities of developing the imaging agent into an effective treatment for prostate cancer. ..
    Miriam Falzon; Fiscal Year: 2009
    ..abstract_text> ..
  29. Chemoprevention of Pancreatic Cancer by Capsaicin
    Sanjay K Srivastava; Fiscal Year: 2013
    ..we found that orally feeding capsaicin significantly retard the growth of AsPC-1 pancreatic tumor xenograft in nude mice with no discernible toxicity...
  30. Mdig gene and histone demethylation in lung cancer
    Fei Chen; Fiscal Year: 2013
    ..To accomplish the objectives of this application, we will pursue three specific aims by using cell lines and nude mice as experimental models: (1) test the potential demethylase activity of mdig protein toward tri-methylated lysine ..
  31. Alcohol and Breast Cancer
    Jia Luo; Fiscal Year: 2012 well as the role of ROS and MUC1 in ethanol- mediated tumorigenesis/metastasis in the transgenic and nude mice. As a cohesive unit, the multi-disciplinary approaches using in vitro and in vivo models will systematically ..
  32. Enhancing Suicide Gene Therapy Through Mechanism-Based Approaches
    Donna S Shewach; Fiscal Year: 2012
    ..Successful testing of these new approaches both in cell culture and in animal models as proposed will justify application of these regimens specifically in men with prostate cancer, and it may have wider applicability to other tumors. ..
  33. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2013
    ..prevents growth and metastasis of human CRC biopsy samples and colon cancer stem cells implanted in athymic nude mice;and 3) determine how AR inhibition prevents the survival of colon cancer stem cells...
  34. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..associated with tumor recurrence and worse prognosis of human HCC and promotes the growth of HCC xenografts in nude mice;in contrast, the related sulfatase SULF1 has a tumor suppressor effect...
  35. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    ..inhibition-mediated changes in angiogenesis and tumor growth in non-GIC and GIC with and without radiation in nude mice. Aim 3a...
  36. Plk1-Numb Cooperation in Melanomagenesis
    Nihal Ahmad; Fiscal Year: 2013 vivo relevance of our in vitro findings by determining the consequence of Plk1 and Numb inhibition in athymic nude mice xenografts implanted with melanoma cells with varying Plk1 and Numb expression...
  37. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
    ..Then, to fully evaluate this combined modality approach in vivo, in human lung tumors growing in the lungs of nude mice, hypothesizing enhancement of effect, and to monitor changes in normal lung tissue, expecting protection against ..
  38. EGFRvIII in Pancreatic Cancer
    Maneesh Jain; Fiscal Year: 2010 a transformed phenotype;that the cells will gain the ability to form foci in soft agar and to form tumors in nude mice. Taken together, these studies will provide the incidence and function of a novel naturally occurring variant of ..
  39. Rho- and GPCR-mediated signaling through novel cellular effectors
    Joan Heller Brown; Fiscal Year: 2012
    ..used to examine the role of CCN1 in tumor cell growth in the chick chorioallantoic membrane (CAM) assay and in nude mice. PUBLIC HEALTH RELEVANCE: Cells receive environmental cues which direct them to proliferate, migrate or die, ..
  40. Development of a nanosecond pulsed electric field system to treat skin cancer
    RICHARD LEE NUCCITELLI; Fiscal Year: 2011
    ..treatment using 100 ns pulses, we can trigger complete remission of malignant melanomas without recurrence in nude mice. During this 6 minute treatment period the tumor is only exposed to the electric field for total of 200 5s yet ..
  41. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..and in setting up xenograft assays where recombinant grafts are implanted under the renal capsule of athymic nude mice. In Aim 2a, human ESCs will be substituted for mouse ESCs...
  42. Stable isotopomer analysis of anabolic metabolic pathways in breast cancer
    Andrew N Lane; Fiscal Year: 2010
    ..Female nude mice bearing mammary fat pad tumors deriving from non MDAMB231 and ZR-75-1 cells are given 13C glucose or 13C/15N ..
  43. 1H MRI based nanosensors for imaging tumor oxygenation
    Vikram D Kodibagkar; Fiscal Year: 2010
    ..Specific Aim 3. (72 mice, months 13-20) To deliver HMDSO nanoprobes intravenously to nude mice bearing human prostate (PC3) and breast (MCF7) tumor xenografts and measure tumor uptake and clearance by MRI: ..
  44. Protein-DNA Drug Carriers for Tumor Targeting
    Lali K Medina-Kauwe; Fiscal Year: 2012
    ..As HER2+ breast cancer does not respond well to conventional therapies, this alternative therapy could provide a significant contribution to breast cancer treatment, and could be modified to target therapy to other types of cancer. ..
  45. The Role of de novo Cytosine DNA Methyltransferases 3a &3b in Gene Methylation
    Ivo Teneng; Fiscal Year: 2013 tobacco carcinogens, and the effect on time to transformation, transformation efficiency, EMT and growth in nude mice will be determined...
  46. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    ..3) evaluate the efficacy of these cells to form functional subunits &rescue function in SMG of nude mice, (4) identify the minimal number of stem cells required for functional rescue, and (5) determine the optimal ..
  47. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
    ..shRNAs had >85% knock-down of MMP-1 compared to MAMMX control shRNAs, and when injected interdermally into nude mice, MMP-1 shRNAs and shMAMMX cells formed primary tumors with similar growth rates...
  48. NPY,Neurovascular Niches and Stress-Induced Remodeling of Adipose Tissue
    John W Osborn; Fiscal Year: 2013
    ..In human Y2Rpositive fat grafted into nude mice, elevated NPY induces vascularization and long-lasting graft survival...
  49. Epigenetic modifications by dietary PEITC in prostate cancer
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..PEITC) and curcumin (CUR) alone and in combination inhibit the development and progression of PCa in nude mice PC-3 xenograft and TRAMP mice via induction of pro-apoptotic and anti-proliferative signaling pathways...
  50. Mechanisms of Human Dermal Fibroblast Migration
    Wei Li; Fiscal Year: 2013
    ..Hsp90? proteins accelerates wound healing by 60% faster than the placebo and three fold faster than Regranex in nude mice (Li et a. 2007, Cheng et al. 2008, Woodley et al. 2009, Cheng et al. 2011)...
  51. Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins
    Laura A Kresty; Fiscal Year: 2013 S-phase delay, causes G2-M cell cycle arrest, and significantly inhibits the growth of OE19 EAC xenografts in nude mice. Despite promising results supporting the chemopreventive application of C-PAC, substantial knowledge gaps ..
  52. Inhibition in the progression of preinvasive lung cancer by pomegranate.
    Naghma Khan; Fiscal Year: 2012
    ..of prosurvival signaling pathways in human lung carcinoma A549 cells and inhibited tumor growth in athymic nude mice and A/J mice...
  53. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
    ..Our overall objective is to investigate the role of MSK1 and Brf1 in the alcohol-induced response that may be critically important in ER+ breast cancer development. ..
  54. The Role of Peroxiredoxin1 &Reactive Oxygen Species in Breast Tumor Initiation
    Carola Anke Neumann; Fiscal Year: 2013
    ..mammary epithelial cells isolated from Prdx1-/-MMTV-ErbB-2 mice and transplant cells into clear fad pads of NCR nude mice, to observe if nuclear Prdx1 decreases incidence of breast cancer or tumor burden...
  55. Cyclophilin B as a therapeutic target in glioblastoma
    Richard J Bram; Fiscal Year: 2013
    ..the effect of CypB ablation in GBMs will be determined in several mouse models, including human xenografts in nude mice and genetically engineered strains...
  56. The GABA-B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2012
    ..of GABA and the GABAB receptor agonist baclophen on early and advanced stages of PDAC xenograft development in nude mice in the presence and absence of stress neurotransmitter stimulation in response to nicotine and NNK...
  57. Role of SIRT1 in melanocyte biology and melanocyte transformation
    Nihal Ahmad; Fiscal Year: 2013 melanocytic cells;and 3) to determine the therapeutic significance of SIRT1 inhibition in vivo in athymic nude mice implanted with melanoma cells...
  58. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013 two human ovarian carcinoma cell lines will be evaluated in cell culture and upon orthotopic tumor growth in nude mice for effects on FA formation-invasion and tumor progression, respectively...
  59. Ack1: Activation and Consequences in Prostate Cancer
    HENRY SHELTON EARP; Fiscal Year: 2012 culture, substantially increased soft agar growth and, as noted, remarkably accelerated tumorigenesis in nude mice, even when castrated prior to tumor implantation...
  60. Novel Strategy to Sensitize Prostate Cancer Cells to Radiation
    Marja T Nevalainen; Fiscal Year: 2013 critical for viability of Stat5a/b-positive PCa cell lies, for growth of human PCa xenograft tumors in nude mice and Stat5a/b promotes metastatic behavior of PCa cells in vitro and in vivo;2) Stat5 regulation of PCa cell ..
  61. Characterization of male germline stem cells in a rhesus model of infertility
    Kyle E Orwig; Fiscal Year: 2012
    ..Responsible development of these ideas in the rhesus model may have implications for treating some cases of male infertility. ..
  62. In vivo detection of involvement of endogenous BM progenitor cells in glioma
    Ali Syed Arbab; Fiscal Year: 2013
    ..Correlation of the accumulated administered stem cells with MRI findings and the expression of different angiogenic receptors will help clinicians to modify treatment strategy when anti-angiogenic therapy is considered. ..
  63. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007 inhibit the invasion and growth of human glioma cell lines injected subcutaneously and intracerebralty in nude mice; and 2b) evaluate and compare the toxicity of the single-gene adenovirus constructs (Ad-uPAR and Ad-pl 6) with ..
    Andrew Schally; Fiscal Year: 1991
    ..will be tested in rat and hamster models of transplanted acinar and ductal pancreatic carcinomas and in nude mice or rats bearing human pancreatic cancer cell lines e.g...
  65. Fatty Acid Synthase Inhibitors: Ovarian Cancer Therapy
    ALBERT OWENS; Fiscal Year: 2007
    ..will have been selected which at <90% of the MTD in normal mice increases the median survival time of athymic nude mice bearing the OVCAR-3 tumor in their peritoneal cavities by at least 25% with <10% weight loss...
  66. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..gamma-tocopherol, when administered by injection starting 24 h pretransplantation, improved the cure rates of nude mice transplanted with the same islet mass as untreated controls by ~70%...
  67. Cyr61-induced breast cancer: Clinical relevance and therapeutic development
    Ruth Lupu; Fiscal Year: 2010
    ..Moreover, forced expression of Cyr61 in breast cells promotes tumor formation in nude mice. Our clinical evaluation of Cyr61 (n=189 paraffin embedded tumor specimens) revealed that 30% of invasive breast ..
    RENA D SOUZA; Fiscal Year: 2001
    ..In the proposed studies, TGF-beta-1(-/-) athymic nude mice will be used to rigorously test the hypothesis that TGF-beta1 is important for odontoblast function during ..
    Vladimir Torchilin; Fiscal Year: 2007
    ..micelles loaded with camptothecin and taxol; determine the maximum tolerated dose (MTD) in C57BL and nude mice; and investigate their tumor accumulation and therapeutic effect in vivo in normal mice bearing either ..
  70. Coexpression of EGFRvlll/ErbB2 in Human Breast Cancer
    Careen Tang; Fiscal Year: 2005
    ..MCF-7) led to increase in colony formation and significantly enhanced tumorigenicity of MCF-7 cells in athymic nude mice. ErbB-2 phosphorylation was enhanced in EGFRvIII transfected MCF-7 cells...
    Reuben Lotan; Fiscal Year: 1991
    ..liver and lung metastases at a higher incidence than a corresponding high expresser cell line when injected into nude mice. To further elucidate the role of sialyl-dimeric LeX antigens in determining human colorectal cancer metastasis, ..
    Andrew Schally; Fiscal Year: 1991
    ..given alone and in combination will be tested in animal models of hormone-dependent mammary carcinoma and in nude mice and nude rats bearing transplanted MCF-7, Beta T-20 and other human breast cancer cell lines, human ovarian ..
    Dihua Yu; Fiscal Year: 2002
    ..The breast cancer cell lines MDA-MB-231 and MCF-7 are metastatic in nude mice after injection into the mammary fatpad...
    SANDRA MCLESKEY; Fiscal Year: 1999
    ..a dramatic change in tumor phenotype when the cells are injected into the mammary fat pads of ovariectomized nude mice. While the parental cells are estrogen- dependent for tumor growth, poorly invasive, and rarely metastatic, the ..
  75. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..We also demonstrated the ability of cathepsin L inhibitor to reverse drug resistance in vivo utilizing nude mice bearing xenografts of doxorubicin resistant neuroblastoma cell line SKN-SH/R drug resistant tumors...
    David Livingston; Fiscal Year: 2007 multiple MDM2- overexpressing human tumor cells lines, interfere with their ability to form tumors in nude mice. If the wt version of one or[unreadable] more of these peptides blocks tumor formation and the mutant(s) do not, ..
    Elizabeth Newcomb; Fiscal Year: 1993
    ..was used to introduce high molecular weight DNA from B-CLL cells into mouse NIH 3T3 cells were inoculated into nude mice. Tumor formation is correlated with the transfer of DNA sequences which contain transforming activity...