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| saimiriSummarySummary: A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies. Top Publications
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Publications
Update on amphetamine neurotoxicity and its relevance to the treatment of ADHDClaire Advokat
Louisiana State University, Baton Rouge, LA 70803, USA
J Atten Disord 11:8-16. 2007..A review of amphetamine treatment for attention-deficit/hyperactivity disorder (ADHD) was conducted, to obtain information on the long-term neurological consequences of this therapy...
Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recoveryS B Frost
Center on Aging, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Neurophysiol 89:3205-14. 2003..Reorganization in intact tissue may provide a neural substrate for adaptive motor behavior and play a critical role in postinjury recovery of function...
Immunogenicity and protective efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus)M Kazanji
Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, 23 Av Pasteur, Cayenne, French Guiana
J Virol 75:5939-48. 2001....
Social organization of a stable natal group of captive Guyanese squirrel monkeys (Saimiri sciureus sciureus)Meredith J Bashaw
Psychology Department, Franklin and Marshall College, PO Box 3003, Lancaster, PA, 17604 3003, USA
Primates 52:361-71. 2011..Wild populations of squirrel monkeys (Saimiri spp.) appear to conform to the predictions of the predation/competition socioecological model (Sterck et al...
Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkeyCecile Le Scanf
Institut Pasteur de la Guyane, BP 6010, 97306 Cayenne Cedex, French Guiana
Microbes Infect 10:447-51. 2008..variant (varO) of the Palo Alto line with a sibling non-rosetting variant (varR) in splenectomized Saimiri monkeys. The multiplication rate of varO parasites was 1.5-fold higher than that of the varR variant...
Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteinsGiselle M Petzinger
George and MaryLou Boone Parkinson's Disease and Movement Disorders Research Center, Department of Neurology, University of Southern California, Los Angeles, California
J Neurosci Res 83:332-47. 2006..In the squirrel monkey (Saimiri sciureus), MPTP-lesioning results in parkinsonian motor symptoms including bradykinesia, postural instability, ..
Optical imaging of intrinsic signals in somatosensory cortexMark Tommerdahl
Department of Biomedical Engineering, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Behav Brain Res 135:83-91. 2002..g. Physiol. Behav. 5 (1970) 1431) when oscillatory tactile stimuli are used...
Fine-scale organization of SI (area 3b) in the squirrel monkey revealed with intrinsic optical imagingL M Chen
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA
J Neurophysiol 86:3011-29. 2001..the somatotopic map and the representation of pressure, flutter, and vibration in area 3b of the squirrel monkey (Saimiri sciureus) cortex under pentothal or isoflurane anesthesia...
Rapid diagnosis and quantification of Francisella tularensis in organs of naturally infected common squirrel monkeys (Saimiri sciureus)Carlos Abril
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, Bern, Switzerland
Vet Microbiol 127:203-8. 2008..tularensis bacteria per simian host cell in two common squirrel monkeys (Saimiri sciureus) from a zoo that died of tularaemia. In other organs such as the brain, F...
Anticipation of future events in squirrel monkeys (Saimiri sciureus) and rats (Rattus norvegicus): tests of the Bischof-Kohler hypothesisMariam Naqshbandi
Department of Psychology, University of Western Ontario, London, ON, Canada
J Comp Psychol 120:345-57. 2006..Tests of the Bischof-Kohler hypothesis were performed with squirrel monkeys (Saimiri sciureus) and rats (Rattus norvegicus)...
Mapping the minimal regions within the ORF73 protein required for herpesvirus saimiri episomal persistenceRhoswyn Griffiths
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
J Gen Virol 89:2843-50. 2008Herpesvirus saimiri (HVS) establishes a persistent infection in which the viral genome persists as a circular non-integrated episome...
The efficacy of combined therapy of arsenic trioxide and alpha interferon in human T-cell leukemia virus type-1-infected squirrel monkeys (Saimiri sciureus)Jean Michel Heraud
, Institut Pasteur de la Guyane, 23, avenue Pasteur, 97306 Cayenne, French Guiana
Antiviral Res 70:132-9. 2006..study, we evaluated the toxicity and the efficacy of this combined treatment in HTLV-1-infected squirrel monkeys (Saimiri sciureus) and HTLV-1 infected cell lines derived therefrom...
Acute reductions in GABAA receptor binding in layer IV of adult primate somatosensory cortex after peripheral nerve injuryC L Wellman
Department of Psychology, Program in Neural Science, Indiana University, Bloomington, IN 47405, USA
Brain Res 954:68-72. 2002..Here we report reductions in GABA(A) receptor binding in layer IV of primate somatosensory cortex deprived of its normal activating inputs for 2-5 h by peripheral nerve transection...
Characterization of the Herpesvirus saimiri Orf51 proteinRobert E Means
Department of Pathology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Virology 326:67-78. 2004Herpesvirus saimiri (HVS) is a gamma(2)-herpesvirus sharing genomic colinearity and a high degree of functional homology with HHV-8...
Object permanence in orangutans (Pongo pygmaeus) and squirrel monkeys (Saimiri sciureus)S T de Blois
Department of Psychology, University of Massachusetts at Amherst, USA
J Comp Psychol 112:137-52. 1998The authors tested orangutans (Pongo pygmaeus) and squirrel monkeys (Saimiri sciureus) on object permanence tasks...
Immunization of Saimiri sciureus monkeys with a recombinant hybrid protein derived from the Plasmodium falciparum antigen glutamate-rich protein and merozoite surface protein 3 can induce partial protection with Freund and Montanide ISA720 adjuvantsLeonardo J M Carvalho
Laboratory of Malaria Research, Department of Immunology, Instituto Oswaldo Cruz FIOCRUZ, Pavilhao Leonidas Deane, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ Brazil 21045 900
Clin Diagn Lab Immunol 12:242-8. 2005..and the C-terminal portion of the merozoite surface protein 3 (MSP3) of Plasmodium falciparum was evaluated in Saimiri sciureus monkeys...
Cortical synaptic arrangements of the third visual pathway in three primate species: Macaca mulatta, Saimiri sciureus, and Aotus trivirgatusYuri Shostak
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232-2175, USA
J Neurosci 22:2885-93. 2002..The basic similarities between K axon circuitry within the CO blobs of the three primate species examined also could indicate that this pathway plays some common role or roles across species...
Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus)F Mortreux
, Institut de Recherche sur le Cancer de Lille, Lille, France
J Virol 75:1083-9. 2001After experimental infection of squirrel monkeys (Saimiri sciureus) with human T-cell leukemia virus type 1 (HTLV-1)-infected cells, the virus is transcribed only transiently in circulating blood, spleen, and lymph nodes...
Quadrupedal locomotion in squirrel monkeys (Cebidae: Saimiri sciureus): a cineradiographic study of limb kinematics and related substrate reaction forcesManuela Schmidt
Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich Schiller Universitat, 07743 Jena, Germany
Am J Phys Anthropol 128:359-70. 2005..Phys. Anthropol. 67:335-349; [1985] Am. J. Phys. Anthropol. 67:351-362), is supported by the high correlation of ratios between forelimb and hindlimb peak vertical forces and the range of motion of shoulder joint and scapula in primates...
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primatesMaya G Purisai
The Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, California 94089, USA
Neurobiol Dis 20:898-906. 2005..They support a direct relationship between neuronal injury and enhanced alpha-synuclein expression, and suggest that protein elevation within cell bodies may be a late feature of neurons that have endured a toxic stress...
Somatotopic reorganization in the brainstem and thalamus following peripheral nerve injury in adult primatesJ D Churchill
Program in Neural Science, Department of Psychology, Indiana University, Bloomington, IN 47405, USA
Brain Res 910:142-52. 2001..These observations are consistent with those previously reported in thalamus, and are unique for brainstem...
Plasmodium simium and Saimiri boliviensis as a model system for testing candidate vaccines against Plasmodium vivaxWilliam E Collins
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Am J Trop Med Hyg 73:644-8. 2005Observations on Plasmodium simium infections in Saimiri boliviensis boliviensis monkeys suggest that this host-parasite combination would be a suitable model for the testing of candidate vaccines against Plasmodium vivax...
Molecular cloning, characterization, and quantification of squirrel monkey ( Saimiri sciureus) Th1 and Th2 cytokinesJean-Michel Heraud
, Institut Pasteur de la Guyane, BP 6010, 23, avenue Pasteur, 97300 Cayenne, French Guiana
Immunogenetics 54:20-9. 2002Primates have long been used as models to study the basic mechanisms of human disease. The squirrel monkey, Saimiri sciureus,is a New World monkey that can be satisfactorily bred in captivity and infected with various human pathogens...
Growth of skeletal components in the young squirrel monkey (Saimiri sciureus boliviensis): a longitudinal experimentH M Pucciarelli
Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Universidad Nacional de La Plata, 1900 La Plata, Argentina
Am J Phys Anthropol 112:57-68. 2000..quot; The acceptance of the hypothesis will imply that all Saimiri skeletal growth may be satisfactorily explained by independent variables in a single equation...
Topographically divergent and convergent connectivity between premotor and primary motor cortexNuma Dancause
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Cereb Cortex 16:1057-68. 2006..To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1...
Sequencing and analysis of genomic DNA and cDNA encoding TNF-alpha in the squirrel monkey (Saimiri sciureus)Fabrice Merien
Centre de Primatologie, Institut Pasteur de la Guyane, BP 6010, 97306 Cayenne Cedex, French Guiana
Vet Immunol Immunopathol 92:37-43. 2003..The corresponding cDNA is 702 nucleotides and phylogenetic analysis showed that the Saimiri sciureus was most closely related to that of the genus Aotus, a new-world primate, compared to old-world primates ..
Phylogeny and phylogeography of squirrel monkeys (genus Saimiri) based on cytochrome b genetic analysisAnne Lavergne
Centre de Primatologie de l Institut Pasteur de la Guyane, Cayenne, French Guiana
Am J Primatol 72:242-53. 2010Squirrel monkeys (genus Saimiri) are distributed over a wide area encompassing the Amazon Basin: French Guiana, Suriname, and Guyana, together with Western Panama and Western Costa Rica...
Meiotic characterization and sex determination system of neotropical primates: Bolivian squirrel monkey Saimiri boliviensis (primates: Cebidae)Eliana R Steinberg
Grupo de Investigación en Biología Evolutiva GIBE, CONICET, Departamento de Ecologia, Genetica y Evolucion, Universidad de Buenos Aires, Ciudad Universitaria, Pab II, 4 degrees Piso, Lab 46, 1428EHA, Buenos Aires, Argentina
Am J Primatol 69:1236-41. 2007..The goal of this study was to characterize the sex determination system of Saimiri boliviensis...
Novel gamma-1 herpesviruses identified in free-ranging new world monkeys (golden-handed tamarin [Saguinus midas], squirrel monkey [Saimiri sciureus], and white-faced saki [Pithecia pithecia]) in French GuianaBenoit de Thoisy
, Institut Pasteur de la Guyane, Cayenne, French Guiana
J Virol 77:9099-105. 2003..lymphocryptoviruses from golden-handed tamarin (Saguinus midas) of the Callitrichidae family and squirrel monkey (Saimiri sciureus) and white-faced saki (Pithecia pithecia) of the Cebidae family...
Genetic analysis of the Saimiri breeding colony of the Pasteur Institute (French Guiana): development of a molecular typing method using a combination of nuclear and mitochondrial DNA markersAnne Lavergne
Centre de Primatologie, Institut Pasteur, Cayenne, , , Pl. E. Bataillon, Montpellier Cedex 5, France
J Med Primatol 32:330-40. 2003b>Saimiri (Cebidae) groups a complex of species and subspecies, which present a large morphological plasticity...
Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted diseaseP Brown
Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
Ann Neurol 35:513-29. 1994....
The composition of milk from Bolivian squirrel monkeys (Saimiri boliviensis boliviensis)Lauren A Milligan
Department of Anthropology, University of Arizona, Tucson, Arizona, USA
Am J Primatol 70:35-43. 2008Squirrel monkeys (genus Saimiri) give birth to relatively large neonates with large, fast-growing brains...
The genome of herpesvirus saimiri C488 which is capable of transforming human T cellsArmin Ensser
, , Schlossgarten 4, D-91054 Erlangen, Germany
Virology 314:471-87. 2003Herpesvirus saimiri (HVS), the rhadinovirus prototype, is apathogenic in the persistently infected natural host, the squirrel monkey, but causes acute T cell leukemia in other New World primate species...
Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeysAlison L McCormack
The Parkinson s Institute, Sunnyvale, California 94085, USA
J Neuropathol Exp Neurol 67:793-802. 2008..The findings are also consistent with a pattern of evolution of alpha-synuclein pathology that may begin with the accumulation and aggregation of the protein within damaged axons...
Testing of Plasmodium vivax CS proteins in Saimiri monkeysW E Collins
Malaria Branch, Centers for Disease Control, Atlanta, GA 30333
Bull World Health Organ 68:42-6. 1990..the circumsporozoite (CS) protein of Plasmodium vivax were tested for safety, immunogenicity, and efficacy in Saimiri sciureus boliviensis monkeys...
Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeysZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 169:135-40. 2003....
Clinical, neuropathological and immunohistochemical features of sporadic and variant forms of Creutzfeldt-Jakob disease in the squirrel monkey (Saimiri sciureus)Lawrence Williams
Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, USA
J Gen Virol 88:688-95. 2007The squirrel monkey (Saimiri sciureus) has been shown to be nearly as susceptible as the chimpanzee to experimentally induced Creutzfeldt-Jakob disease (CJD), and has been used extensively in diagnostic and pathogenetic studies...
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)Weiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Alzheimers Dis 10:417-22. 2006..In this study we continued to explore the role of CR in AD-type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)...
Aging of the nigrostriatal system in the squirrel monkeyAlison L McCormack
The Parkinson s Institute, Sunnyvale, California 94089, USA
J Comp Neurol 471:387-95. 2004..NM content appears to be an important marker of these age-related effects...
Modeling dichromatic and trichromatic sensitivity to the color properties of fruits eaten by squirrel monkeys (Saimiri sciureus)Mariana F P De Araújo
Laboratório de Neurociências e Comportamento, CFS, IB, Universidade de Brasilia, Brazil
Am J Primatol 68:1129-37. 2006..In this study the reflectance spectra of fruits and flowers eaten by a troop of squirrel monkeys (Saimiri sciureus) in Eastern Amazon were measured using a spectrophotometer. S...
Detection of squirrel monkey retroviral sequences in interferon samplesM Pienkowska
Laboratory of Molecular Pathology, Women s College Hospital, Toronto, Ontario, Canada
J Hepatol 28:396-403. 1998..However, it remains to be determined whether the residual DNA sequences detected by our sensitive nested polymerase chain reaction assay have biological consequences...
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levelsL J M Carvalho
Laboratory of Malaria Research, Department of Immunology, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
Scand J Immunol 59:363-72. 2004..protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys...
Immunocytochemistry of oculomotor afferents in the squirrel monkey (Saimiri sciureus)M B Carpenter
Department of Anatomy, , Uniformed Services University of the Health Sciences, Bethesda, Maryland
J Hirnforsch 33:151-67. 1992..No other GLU- or ASP-positive neurons were immunoreactive for GABA, 5-HT or CCK, but cells of the lateral vestibular nucleus were surrounded by CCK-IR fibers and terminals...
Laryngeal biomechanics and vocal communication in the squirrel monkey (Saimiri boliviensis)Charles H Brown
Department of Psychology, University of South Alabama, Mobile, Alabama 36688, USA
J Acoust Soc Am 113:2114-26. 2003..In regime 4, the period of each oscillation was quasi-irregular. Shrieks and other broadband calls or call elements that lack an apparent fundamental frequency may be produced in this manner...
Optical imaging of a tactile illusion in area 3b of the primary somatosensory cortexLi M Chen
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 302:881-5. 2003..Thus, in contrast to traditional views of the body map, topographic representation in the SI reflects the perceived rather than the physical location of peripheral stimulation...
Time-dependence of SI RA neuron response to cutaneous flutter stimulationB L Whitsel
Department of Diagnostic Sciences, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Somatosens Mot Res 20:45-69. 2003..Parallels with recent proposals about the contributions to visual perception of short-term primary sensory cortical neuron dynamics and synchrony in multineuron spike activity patterns are identified and discussed...
Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)Richard F Marsh
Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
J Virol 79:13794-6. 2005..Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates...
A squirrel monkey model of poststroke motor recoveryRandolph J Nudo
Center on Aging, Department of Physiology, University of Kansas Medical Center, Kansas City, USA
ILAR J 44:161-74. 2003..This methodology is described in detail, and many of the resulting findings that are relevant for understanding stroke recovery and the effects of rehabilitative and pharmacotherapeutic interventions are summarized...
Anatomic correlates of the face and oral cavity representations in the somatosensory cortical area 3b of monkeysN Jain
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
J Comp Neurol 429:455-68. 2001....
Ipsilateral connections of the ventral premotor cortex in a new world primateNuma Dancause
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Comp Neurol 495:374-90. 2006..No statistical difference between the proportions of inputs and outputs for any location was observed, supporting the reciprocity of PMv intracortical connections...
Chimeric peptide vaccine composed of B- and T-cell epitopes of human T-cell leukemia virus type 1 induces humoral and cellular immune responses and reduces the proviral load in immunized squirrel monkeys (Saimiri sciureus)Mirdad Kazanji
Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, French Guiana
J Gen Virol 87:1331-7. 2006..After challenge, it was shown by competitive PCR that partial protection against HTLV-1 infection could be raised in immunized animals. Further studies should be developed to determine the duration of this protection...
Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortexNuma Dancause
Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 673, Rochester, NY 14642, USA
J Neurophysiol 96:3506-11. 2006....
Lymphoid organs as a major reservoir for human T-cell leukemia virus type 1 in experimentally infected squirrel monkeys (Saimiri sciureus): provirus expression, persistence, and humoral and cellular immune responsesM Kazanji
Unité d Oncologie Virale, Institut Pasteur, Paris, France
J Virol 74:4860-7. 2000..of human T-cell leukemia virus type 1 (HTLV-1) in various organs of serially sacrificed squirrel monkeys (Saimiri sciureus) in order to localize the reservoir of the virus and to evaluate the relationship between viral ..
Evaluation of immunogenicity and protective efficacy of carrier-free Plasmodium falciparum R23 antigen in pre-exposed saimiri sciureus monkeysR Perraut
Unite d immunologie, Institut Pasteur de Dakar, BP 220, Dakar, Senegal
Vaccine 19:59-67. 2000..recombinant Glutathione S-transferase GTR23, induced protection after immunisation of naive or previously exposed Saimiri monkeys...
HTLV type 1 infection in squirrel monkeys (Saimiri sciureus): a promising animal model for HTLV type 1 human infectionM Kazanji
Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, 97306 Cayenne, French Guiana
AIDS Res Hum Retroviruses 16:1741-6. 2000We show that the squirrel monkey Saimiri sciureus is susceptible to experimental infection with either syngeneic or allogeneic HTLV-1-immortalized cells...
Interhemispheric connections of the ventral premotor cortex in a new world primateNuma Dancause
Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Comp Neurol 505:701-15. 2007..They help to provide an anatomical foundation for understanding PMv's role in motor control of the hand and interhemispheric interactions that may underlie the coordination of bimanual movements...
Subcellular and subsynaptic localization of presynaptic and postsynaptic kainate receptor subunits in the monkey striatumJ Z Kieval
Division of Neuroscience, Yerkes Regional Primate Research Center, and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 21:8746-57. 2001....
Telemetrically recorded neuronal activity in the inferior colliculus and bordering tegmentum during vocal communication in squirrel monkeys (Saimiri sciureus)Roland Tammer
German Primate Centre, Kellnerweg 4, , Germany
Behav Brain Res 151:331-6. 2004..The experiments were made in the squirrel monkey (Saimiri sciureus), using a telemetric extracellular recording technique which allowed to register neuronal activity in ..
The chemo- and somatotopic architecture of the Galago cuneate and gracile nucleiF Strata
Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
Neuroscience 116:831-50. 2003..In conclusion, the different pattern of segregation of the inputs from the hand and from the foot can be related to the different metabolic organization of the cuneate and of the gracile, respectively...
Neuronal activity in the inferior colliculus and bordering structures during vocalization in the squirrel monkeyFlorian Pieper
German Primate Center, Kellnerweg 4, 37077, , Germany
Brain Res 979:153-64. 2003In four squirrel monkeys (Saimiri sciureus), the inferior colliculus, together with the neighboring superior colliculus, reticular formation, cuneiform nucleus and parabrachial area, were explored with microelectrodes, looking for ..
Localization of a vocal pattern generator in the pontine brainstem of the squirrel monkeySteffen R Hage
Department of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur J Neurosci 23:840-4. 2006..Based on these findings and previously reported anatomical data, we propose that this area serves as a vocal pattern generator for frequency-modulated call types...
Neuroscience. Illusions and perceived images in the primate brainUlf T Eysel
Department of Neurophysiology, Ruhr-University-Bochum, Bochum 44780, Germany
Science 302:789-91. 2003
Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and a two-compartment modelAnne Catherin Zappe
Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
Magn Reson Imaging 25:775-83. 2007..The CBF values in the occipital lobe of the monkey brain quantified with ASL are higher than previously reported in positron emission tomography studies...
Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-Stephanie C Licata
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
J Pharmacol Exp Ther 313:1118-25. 2005..Moreover, a compound with reduced efficacy at alpha(1) GABA(A) and/or alpha(5) GABA(A) receptors may lack some of the motor and subjective effects associated with conventional BZs...
Enhanced striatal opioid receptor-mediated G-protein activation in L-DOPA-treated dyskinetic monkeysL Chen
The Parkinson's Institute, Basic Research Department, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Neuroscience 132:409-20. 2005..The positive correlation with LIDs suggests this may represent an intracellular signaling mechanism underlying these movement abnormalities...
Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha allelesLaura M J Ylinen
Wohl Virion Center, Division of Infection and Immunity, Windeyer Building, University College London, 46 Cleveland St, London W1T4JF, United Kingdom
J Virol 79:11580-7. 2005..We map the determinant for TRIM5alpha sensitivity to the structure in the capsid protein that recruits CypA into HIV-1 virions. We also make an SIV, mutated at this site, which bypasses restriction in all cells tested...
CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferentsY Smith
Yerkes Regional Primate Research Center, Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 407:491-511. 1999....
The Plasmodium vivax homologues of merozoite surface proteins 4 and 5 from Plasmodium falciparum are expressed at different locations in the merozoiteCasilda G Black
Department of Microbiology, Monash University, PO Box 53, Calyton 3800 Victoria, Australia
Mol Biochem Parasitol 120:215-24. 2002..vivax merozoites, as expected, whereas, the MSP5 homologue was found to be associated with an apical organellar location consistent with micronemes or over the polar prominence...
TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activityByeongwoon Song
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
Virology 343:201-11. 2005..Apparently, the formation of cytoplasmic bodies is not required for the antiretroviral activity of TRIM5alpha...
Group I metabotropic glutamate receptors in the monkey striatum: subsynaptic association with glutamatergic and dopaminergic afferentsMaryse Paquet
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 23:7659-69. 2003....
Firing behaviour of squirrel monkey eye movement-related vestibular nucleus neurons during gaze saccadesRobert A McCrea
Department of Neurobiology, Pharmacology and Physiology, Committee on Neurobiology, University of Chicago, 5806 South Ellis Avenue, Chicago, IL 60637, USA
J Physiol 546:207-24. 2003..The convergence of motor and sensory reafferent inputs on VOR pathways provides a mechanism for separate control of eye and head movements during and after saccadic gaze shifts...
Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")George A Ricaurte
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Science 297:2260-3. 2002....
Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brainMichael Rigby
In Vivo Neuroscience, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
J Comp Neurol 490:335-53. 2005..These findings demonstrate that the NK1 receptor is the predominant tachykinin receptor expressed in primate and human brain, but that low levels of NK3 receptor are present in nonhuman, primate brain...
Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560Kevin P Bateman
Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Pointe Claire Dorval, Kirkland, Quebec, Canada
J Mass Spectrom 41:771-80. 2006..No major species differences were found in terms of microsomal metabolite profiles. The use of LC with UV and MS detection is highlighted, as well as information from tandem mass spectrometry and NMR...
Detecting danger--or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammalsMatthias Laska
Department of Medical Psychology, University of Munich Medical School, Goethestr 31, D 80336 Munich, Germany
Physiol Behav 84:211-5. 2005..Thus, these results support the assumption that the behavioral relevance of an odorant may be an important determinant of a species' olfactory sensitivity...
Neurokinin-1 and neurokinin-3 receptors in primate substantia nigraMartin Levesque
Centre de Recherche Université Laval Robert Giffard 2601, chemin de la Canardiere, Local F 6500 Beauport, Quebec, Canada
Neurosci Res 57:362-71. 2007....
Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primatesMaryka Quik
The Parkinson s Institute, Sunnyvale, California, USA
J Neurochem 98:1866-75. 2006..These data further support the possibility that nicotine contributes to the lower incidence of Parkinson's disease in smokers...
Susceptibility of Anopheles farauti to infection with different species of PlasmodiumDouglas Nace
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Chamblee, GA 30341, USA
J Am Mosq Control Assoc 20:272-6. 2004..freeborni and An. stephensi. This colony adapted well to feeding on monkeys and was infected with New World and Old World strains of P. vivax and P. falciparum, P. ovale, P. cynomolgi, and P. brasilianum...
Proliferating cells can differentiate into neurons in the striatum of normal adult monkeyAndreanne Bedard
Centre de Recherche Université Laval Robert Giffard 2601, chemin de la Canardiere, Local F 6500, Quebec, G1J 2G3, Beauport, Canada
Neurosci Lett 328:213-6. 2002..the DNA of mitotic cells, to study the cytogenesis status of the striatum in normal, adult, squirrel monkeys (Saimiri sciureus)...
Chemical characterization of newly generated neurons in the striatum of adult primatesAndreanne Bedard
Centre de Recherche Université Laval Robert Giffard 2601, de la Canardière, Local F 6500, Beauport, Quebec, G1 J 2G3, Canada
Exp Brain Res 170:501-12. 2006....
Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primatesMaryka Quik
The Parkinson s Institute, Sunnyvale, California 94089, USA
J Neurosci 26:4681-9. 2006..These cellular alterations may underlie the ability of nicotine to maintain/restore normal function with nigrostriatal damage...
Novel aspects of the chemical anatomy of the striatum and its efferents projectionsMartin Levesque
Centre de Recherche Universite Laval Robert Giffard, 2601, de la Canardière, Local F 6500, Que, G1J 2G3, Beauport, Canada
J Chem Neuroanat 26:271-81. 2003..These findings open new therapeutic avenues for the treatment of neurodegenerative disorders that specifically affect the striatum...
Neurochemically defined cell columns in the nucleus prepositus hypoglossi of the cat and monkeyJoan S Baizer
Department of Physiology and Biophysics, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214 3078, USA
Brain Res 1094:127-37. 2006..Populations of 8B3 and nNOS-immunoreactive cells are also found in PH of squirrel and macaque monkeys. The results suggest that nNOS-immunoreactive cells in PH may consist of two functionally different populations...
Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeysDonna M Platt
New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
J Pharmacol Exp Ther 322:894-902. 2007..Squirrel monkeys (Saimiri sciureus) were trained to stability under a second-order fixed interval, fixed ratio schedule of drug self-..
Cytopathological changes in human and animals brains in prion diseasesV Ya Karmysheva
Laboratory for Encephalitis Immunology, M P Chumakov Institute of Poliomyelitis and Viral Encephalitis, Russian Academy of Medical Sciences, Moscow
Neurosci Behav Physiol 34:509-13. 2004....
Striosomes are enriched in glutamic acid decarboxylase in primatesMartin Levesque
Centre de Recherche Universite Laval Robert Giffard, 2601, de la Canardière, Local F 6500, Beauport, Quebec, Canada G1J 2G3
Neurosci Res 50:29-35. 2004....
Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeysHeather L Kimmel
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
Pharmacol Biochem Behav 86:45-54. 2007..Hence, there was a general trend for compounds that had a faster onset and/or DAT selectivity to produce significant behavioral-stimulant and reinforcing effects...
Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeysDonna M Platt
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, PO Box 9102, MA 01772 9102, Southborough, USA
Psychopharmacology (Berl) 166:298-305. 2003..The D2-like receptor partial agonist terguride has a profile of behavioral effects in rats that suggests potential benefit as a pharmacotherapy for cocaine addiction...
Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeysBuyean Lee
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Neuropsychopharmacology 29:686-93. 2004....
Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeysPaul W Czoty
Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Pharmacol Exp Ther 300:831-7. 2002..These findings extend those reported previously for the behavioral-stimulant effects of cocaine and identify a potential neurochemical mechanism underlying drug interactions on behavior...
Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeysSevil Yasar
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Eur J Pharmacol 465:257-65. 2003..The failure of AWD 131-138 to produce benzodiazepine-like discriminative effects and the absence of drug self-administration behavior when substituted for cocaine suggest that its abuse liability is low...
The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeysZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 173:186-94. 2004..These findings demonstrate for the first time the modulation of the reinforcing effects of THC by an opioid antagonist in a non-human primate model of marijuana abuse...
Methamphetamine discrimination and in vivo microdialysis in squirrel monkeysPaul W Czoty
McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 175:170-8. 2004..CONCLUSIONS: Taken together, these results support a prominent role for dopamine in MA-like discriminative-stimulus effects, but are consistent with the additional involvement of other neurochemical actions...
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primatesErik J Plautz
Department of Molecular and Integrative Physiology, Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
Neurol Res 25:801-10. 2003..Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury...
Cocaine self-administration under variable-dose schedules in squirrel monkeysLeigh V Panlilio
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Pharmacol Biochem Behav 84:235-43. 2006..The dose-dependency of run rates suggests that post-injection pauses reflect not only motivational factors, such as satiety, but also the direct effects of cocaine on leverpressing...
Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representationKathleen M Friel
Department of Molecular and Integrative Physiology, Landon Center on Aging, University of Kansas Medical Center, Kansas City, Kansas, USA
J Neurophysiol 94:1312-24. 2005..Rostral and caudal M1 lesions result in different deficits in sensory-dependent motor control that appear to correlate with broad segregation of motor outputs and previously described sensory inputs of M1...
Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpineBuyean Lee
Harvard Medical School, New England Primate Research Center, P.O. Box 9102, Southborough, MA 01772-9102, USA
J Pharmacol Exp Ther 312:1232-40. 2005..The contrasting interactions of MPEP and dizocilpine with cocaine imply that glutamate acting through different metabotropic and ionotropic receptors may modulate the behavioral effects of cocaine in qualitatively different ways...
Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeysScott Barbay
Landon Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
Exp Brain Res 169:106-16. 2006..These results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke...
Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neuronsAnnis Mechan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:339-50. 2006....
Subdivisions of inferior temporal cortex in squirrel monkeys make dissociable contributions to visual learning and memoryRosalyn E Weller
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
Behav Neurosci 120:423-46. 2006..The ITRd monkeys were significantly impaired on DNMS and some pattern discriminations. These results are similar to those found in macaques and support the proposed homologies...
Repetitive behaviors in monkeys are linked to specific striatal activation patternsEsen Saka
Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
J Neurosci 24:7557-65. 2004....
Research Grants
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXChristoph E Schreiner; Fiscal Year: 2011..the organization of two primary auditory fields in adult carnivores (Felis catus) and the awake squirrel monkey (Saimiri sciureus) with specific reference to functional domains and laminar organization...
- HHV-8 AND ITS ROLE IN HUMAN DISEASEGary Hayward; Fiscal Year: 2000..has revealed that HHV-8 is most closely related to the squirrel monkey gamma-2 class genome of herpesvirus saimiri. Although its identity as an authentic human infectious pathogen has yet to be formally validated, expression of ..
- ROLE OF VIL-6 IN PRIMARY EFFUSION LYMPHOMASJohn Nicholas; Fiscal Year: 2004..and that of the herpesviruses for which sequence data are available it is most closely related to herpesvirus saimiri (HVS)...
- KS ASSOCIATED DNA VIRUSYuan Chang; Fiscal Year: 1999..an approximately 270 kb genome, homologous to the Gammaherpesvirinae Epstein-Barr virus (EBV) and herpesvirus saimiri (HSVSA)...
- KAPOSI SARCOMA ASSOCIATED HERPESVIRUS PATHOGENESISJae Jung; Fiscal Year: 2002..of KSHV genomic sequences has revealed that KSHV is a gamma herpesvirus that is closely related to herpesvirus saimiri (HVS) of New World primates and to the recently isolated rhesus rhadinovirus (RRV)...
- MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENSMary Galinski; Fiscal Year: 2004..Selected proteins will also be tested for their safety, immunogenicity and efficacy as immunogens in Saimiri monkeys.
- Structural Dynamics of Src-Family Kinase ActivationJOHN ENGEN; Fiscal Year: 2007..Activation of Hck by HIV Nef and Lck by the Tip protein from Herpesvirus saimiri will be probed with HXMS...
- HIV1 INHIBITORY PROTEINS FROM TRANSFORMED CD8+ CELLSMary Klotman; Fiscal Year: 2002..Herpesvirus saimiri (HVS)-transformed CD8+ cells have proven to provide a continuous source of supernatant with potent HIV-1 ..
- Toward a new world monkey model of HIV-1 infectionMichael Farzan; Fiscal Year: 2007..owl monkey (Aotus trivirgatus) and the common marmoset (Callithrixjacchus), but not those of the squirrel monkey (Saimiri sciureus), can be readily overcome...
- Role and mechanism of action of Gamma herpesvirus microRNAsBryan R Cullen; Fiscal Year: 2010..encoded by KSHV, EBV and by the related Simian Gamma herpesviruses Rhesus Rhadinovirus (RRV) and herpesvirus Saimiri (HVS)...
- Role and mechanism of action of Gamma herpesvirus microRNAsBRYAN CULLEN; Fiscal Year: 2007..encoded by KSHV, EBV and by the related Simian Gamma herpesviruses Rhesus Rhadinovirus (RRV) and herpesvirus Saimiri (HVS)...
- BCL-2 HOMOLOGY OF HUMAN HERPESVIRUS 8J Hardwick; Fiscal Year: 2000..Preliminary studies on the bcl-2 homolog encoded by herpesvirus saimiri indicate that gamma herpesviruses require an inhibitor of apoptosis to successfully complete the lytic ..
- CRYSTALLOGRAPHIC STUDIES OF VIRAL CYCLINS AND CDK6Ursula Schulze Gahmen; Fiscal Year: 2002..V-cyclin from herpesvirus saimiri (HVS) and k- cyclin from Kaposi's sarcoma associated herpesvirus (KSHV) show 24 percent and 31 percent identity ..
