Genomes and Genes
Summary: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Articles from Journal RESEARCH
Articles from Journal RESEARCH3
Publications378 found, 100 shown here
- Genome sequence, comparative analysis, and population genetics of the domestic horseC M Wade
Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
Science 326:865-7. 2009..Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
- A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studiesMolly E McCue
College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA
PLoS Genet 8:e1002451. 2012..These results demonstrate the high quality of this SNP genotyping resource, its usefulness in diverse genome analyses of the horse, and potential use in related species...
- Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equidsLubna Nasir
Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH
Vet Dermatol 19:243-54. 2008..Only limited information on the clinical or pathological aspects of either bovine or equine tumours will be provided as this subject has been extensively addressed previously...
- High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samplesA Van den Eede
Department of Surgery and Anaesthesiology of Domestic Animals, Ghent University, Faculty of Veterinary Medicine, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 133:138-44. 2009..Little is known, however, about their origin and the general equine MRSA colonization status. In West European horses in particular, neither the colonization rate nor the present strains or their antimicrobial susceptibility ..
- A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorsesEmmeline W Hill
Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 11:552. 2010Thoroughbred horses have been selected for traits contributing to speed and stamina for centuries...
- Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domesticationAlessandro Achilli
Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, 06123 Perugia, Italy
Proc Natl Acad Sci U S A 109:2449-54. 2012..mtDNA phylogeny to the highest level of molecular resolution by analyzing 83 mitochondrial genomes from modern horses across Asia, Europe, the Middle East, and the Americas...
- Four loci explain 83% of size variation in the horseShokouh Makvandi-Nejad
Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America
PLoS ONE 7:e39929. 2012..humans, which are naturally reproducing and possess many genetic variants with weak effects on size, we show that horses, like other domestic mammals, carry just a small number of size loci with alleles of large effect...
- A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horseGerli Rosengren Pielberg
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
Nat Genet 40:1004-9. 2008In horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4...
- Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal SyndromeSamantha A Brooks
Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
PLoS Genet 6:e1000909. 2010Lavender Foal Syndrome (LFS) is a lethal inherited disease of horses with a suspected autosomal recessive mode of inheritance. LFS has been primarily diagnosed in a subgroup of the Arabian breed, the Egyptian Arabian horse...
- Intra- and interhost evolutionary dynamics of equine influenza virusPablo R Murcia
Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES Cambridge, England, United Kingdom
J Virol 84:6943-54. 2010..We studied the dynamics of equine influenza virus evolution in horses at the intrahost level and how this evolutionary process is affected by interhost transmission in a natural ..
- A genome-wide association study reveals loci influencing height and other conformation traits in horsesHeidi Signer-Hasler
School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences, Zollikofen, Switzerland
PLoS ONE 7:e37282. 2012..We performed a genome-wide association study on 1,077 Franches-Montagnes (FM) horses using ∼40,000 SNPs. Our study revealed two QTL for height at withers on chromosomes 3 and 9...
- Characterization of the fecal bacteria communities of forage-fed horses by pyrosequencing of 16S rRNA V4 gene ampliconsMegan L Shepherd
Large Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA
FEMS Microbiol Lett 326:62-8. 2012..Fecal samples were obtained from horses fed cool-season grass hay...
- Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoidG Borzacchiello
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
J Comp Pathol 139:231-7. 2008..These findings add further weight to the theory that BPV and the PDGF-betaR may have a role in the pathogenesis of this disease...
- Establishment and characterization of equine fibroblast cell lines transformed in vivo and in vitro by BPV-1: model systems for equine sarcoidsZ Q Yuan
Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
Virology 373:352-61. 2008..These findings confirm that the virus has an active role in the induction of sarcoids and the lines will be invaluable for further studies on the role of BPV-1 in sarcoid pathology...
- Hendra virus outbreak with novel clinical features, AustraliaHume Field
Biosecurity Queensland, Brisbane, Queensland, Australia hume fi
Emerg Infect Dis 16:338-40. 2010..Four of 5 infected horses died, as did 1 of 2 infected staff members. Clinical manifestation in horses was predominantly neurologic...
- Re-emergence of bluetongue, African horse sickness, and other orbivirus diseasesN James MacLachlan
Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA
Vet Res 41:35. 2010....
- Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureusBirgit Walther
Institute of Microbiology and Epizootics IMT, Free University Berlin, Philippstrasse 13, 10115 Berlin, Germany
J Clin Microbiol 47:704-10. 2009..Staphylococcus aureus (MRSA) in veterinary medicine, knowledge about the epidemiology of the pathogen in horses is still poor...
- Horses (Equus caballus) select the greater of two quantities in small numerical contrastsClaudia Uller
Department of Psychology, University of Essex, Essex CO4 3SQ, UK
Anim Cogn 12:733-8. 2009..We tested 56 horses (Equus caballus) in a paradigm previously used with human infants and nonhuman primates...
- Horses damp the spring in their stepA M Wilson
Department of Veterinary Basic Sciences, The Royal Veterinary College, Hatfield, Herts AL9 7TA, UK
Nature 414:895-9. 2001The muscular work of galloping in horses is halved by storing and returning elastic strain energy in spring-like muscle-tendon units.These make the legs act like a child's pogo stick that is tuned to stretch and recoil at 2...
- Rhodococcus equi: clinical manifestations, virulence, and immunityS Giguere
Department of Large Animal Medicine, University of Georgia, Athens, GA 30602, USA
J Vet Intern Med 25:1221-30. 2011..equi. A complementary consensus statement providing recommendations for the diagnosis, treatment, control, and prevention of infections caused by R. equi in foals can be found in the same issue of the Journal...
- Persistently infected horses are reservoirs for intrastadial tick-borne transmission of the apicomplexan parasite Babesia equiMassaro W Ueti
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
Infect Immun 76:3525-9. 2008..protozoal pathogen Babesia equi during acute and persistent infections and transmit it intrastadially to naïve horses. Although the level of parasitemia during acquisition feeding affected the efficiency of the initial tick ..
- Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemiaMassaro W Ueti
Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
J Clin Microbiol 43:3755-9. 2005..equi can reach high levels of parasitemia, resulting in a hemolytic crisis. Horses that recover from the acute phase of the disease remain chronically infected...
- Cloning of the genome of equine herpesvirus 4 strain TH20p as an infectious bacterial artificial chromosomeWalid Azab
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Arch Virol 154:833-42. 2009Equine herpesvirus 4 (EHV-4) is a major cause of respiratory tract disease in horses worldwide...
- Effects of platelet-rich plasma on the repair of wounds on the distal aspect of the forelimb in horsesSusana O Monteiro
Ecole Nationale Veterinaire de Lyon, Département hippique, Marcy l Etoile, F 69280, France
Am J Vet Res 70:277-82. 2009To evaluate the effect of platelet-rich plasma on wounds on the distal aspect of the forelimb in horses.
- Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospitalChristiane Cuny
Wernigerode Branch, Robert Koch Institute, Wernigerode, Germany
Microb Drug Resist 14:307-10. 2008During 2006 and 2007 small clusters of methicillin-resistant Staphylococcus aureus (MRSA) infections in horses were recorded in different clinical departments of a veterinary university...
- Widespread origins of domestic horse lineagesC Vila
Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, S 75236 Uppsala, Sweden
Science 291:474-7. 2001..We analyzed mitochondrial DNA (mtDNA) control region sequences of 191 domestic horses and found a high diversity of matrilines...
- Whole mitochondrial genome sequencing of domestic horses reveals incorporation of extensive wild horse diversity during domesticationSebastian Lippold
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
BMC Evol Biol 11:328. 2011..Previously, whole mitochondrial genome data for domestic horses (Equus caballus) were limited to only a few specimens and only short parts of the mtDNA genome (especially the ..
- Experimental infection of horses with Hendra virus/Australia/horse/2008/RedlandsGlenn A Marsh
Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Victoria, Australia
Emerg Infect Dis 17:2232-8. 2011..highly pathogenic zoonotic paramyxovirus harbored by Australian flying foxes with sporadic spillovers directly to horses. Although the mode and critical control points of HeV spillover to horses from flying foxes, and the risk for ..
- Reconstructing the origin and spread of horse domestication in the Eurasian steppeVera Warmuth
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Proc Natl Acad Sci U S A 109:8202-6. 2012..sequencing, a number of different domestication scenarios have been proposed, ranging from the spread of domestic horses out of a restricted primary area of domestication to the domestication of numerous distinct wild horse populations...
- A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammalsNandina Paria
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
PLoS ONE 6:e21374. 2011....
- Bovine papillomavirus E7 oncoprotein binds to p600 in naturally occurring equine sarcoidsAnnunziata Corteggio
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via Veterinaria 1, 80137 Naples, Italy
J Gen Virol 92:378-82. 2011..Finally, the system provides a suitable animal model of papillomavirus-associated cancer to test therapeutic vaccination against E7...
- Seroprevalence of Toxoplasma gondii infection among horses in TunisiaSonia Boughattas
Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, 13 Place Pasteur BP74, 1002 Tunis Belvédères, Tunisia
Parasit Vectors 4:218. 2011The present study was conducted to investigate the serological survey of Toxoplasma antibodies in local.horses from three major regions: a neighbourhood of a city in the North (Sidi Thabet), a neighbourhood of a city on the coast (..
- Methicillin-resistant Staphylococcus aureus in horses and horse personnel: an investigation of several outbreaksE van Duijkeren
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, PO Box 80165, 3508 TD Utrecht, Utrecht University, The Netherlands
Vet Microbiol 141:96-102. 2010..During an outbreak of post-surgical MRSA infections in horses at a veterinary teaching hospital in 2006/2007, MRSA isolates of spa-type t2123 were cultured from 7 horses and 4/..
- Cross-modal individual recognition in domestic horses (Equus caballus)Leanne Proops
Centre for Mammal Vocal Communication Research, Department of Psychology, School of Life Sciences, University of Sussex, Brighton BN1 9QH, United Kingdom
Proc Natl Acad Sci U S A 106:947-51. 2009..When horses were shown one associate and then the call of a different associate was played, they responded more quickly and ..
- A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horsesEmmeline W Hill
Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
PLoS ONE 5:e8645. 2010..Using a sample of registered Thoroughbred horses (n = 148), we have identified a novel MSTN sequence polymorphism that is strongly associated (g...
- Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008Elliott G Playford
Pathology Queensland, Brisbane, Queensland, Australia
Emerg Infect Dis 16:219-23. 2010..In contrast to previous outbreaks, infected horses had predominantly encephalitic, rather than respiratory, signs...
- Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogensMatthew T G Holden
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
PLoS Pathog 5:e1000346. 2009..Streptococcus equi subspecies equi (S. equi) is a host-restricted pathogen of horses that has evolved from the zoonotic pathogen Streptococcus equi subspecies zooepidemicus (S. zooepidemicus)...
- Analysis of local spread of equine influenza in the Park Ridge region of QueenslandJ Davis
Office of the Chief Veterinary Officer, Department of Agriculture Fisheries and Forestry, Canberra, Australia
Transbound Emerg Dis 56:31-8. 2009..The findings were consistent with the conclusion that EI will routinely spread over 1-2 km via wind-borne aerosol...
- Histopathological characteristics of five clinical types of equine sarcoidA Martens
Department of Large Animal Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Res Vet Sci 69:295-300. 2000..The presence of other microscopic alterations was variable but could not be used in the differentiation of the clinical types based on histology...
- Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6Lisa S Andersson
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
BMC Genet 9:88. 2008..MCOA is most common in the Rocky Mountain horse breed where it occurs at a high frequency among Silver colored horses. The Silver coat color is associated with mutations in PMEL17 that resides on ECA6q23...
- A serological survey of pigs, horses, and ducks in Nepal for evidence of infection with Japanese encephalitis virusGanesh R Pant
Central Veterinary Laboratory, Tripureshwor, Kathmandu, Nepal
Ann N Y Acad Sci 1081:124-9. 2006..to JE virus was conducted in Nepal from September 2003 to August 2004 by collecting 280 sera from pigs, ducks, and horses covering 10 districts of the country...
- A critical review of fear tests used on cattle, pigs, sheep, poultry and horsesB Forkman
Department of Large Animal Sciences, Roy Vet Agricult Univ, 1870 Frederiksberg, Denmark
Physiol Behav 92:340-74. 2007..the level of repeatability and validity found for fear tests used on cattle, pigs, sheep and goats, poultry and horses. We focus the review on the three most common types of fear tests: the arena test (open field), the novel object ..
- Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine modelMarkus M Wilke
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3 187, Ithaca, New York 14853, USA
J Orthop Res 25:913-25. 2007..Twelve full-thickness 15-mm cartilage lesions in the femoropatellar articulations of six young mature horses were repaired by injection of a self-polymerizing autogenous fibrin vehicle containing mesenchymal stem cells, or ..
- Pro-inflammatory and antiviral cytokine expression in vaccinated and unvaccinated horses exposed to equine influenza virusMichelle Quinlivan
Virology Unit, Irish Equine Centre, Johnstown, Naas, Co Kildare, Ireland
Vaccine 25:7056-64. 2007..An experimental challenge study was undertaken in unvaccinated naïve horses and horses vaccinated with a commercial inactivated influenza vaccine...
- Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist geneD D Frisbie
Equine Orthopaedic Research Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
Gene Ther 9:12-20. 2002Osteoarthritis in horses and in humans is a significant social and economic problem and continued research and improvements in therapy are needed...
- A mutation in the MATP gene causes the cream coat colour in the horseDenis Mariat
Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, Institut National de la Recherche Agronomique, Centre de Recherche de Jouy, 78352 Jouy en Josas Cedex, France
Genet Sel Evol 35:119-33. 2003In horses, basic colours such as bay or chestnut may be partially diluted to buckskin and palomino, or extremely diluted to cream, a nearly white colour with pink skin and blue eyes...
- Evaluation of prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in veterinary personnel attending an international equine veterinary conferenceMaureen E C Anderson
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
Vet Microbiol 129:410-7. 2008..aureus (MRSA) are now increasingly being reported in animals and people who work with animals, including horses and horse personnel...
- Endothelin receptor B polymorphism associated with lethal white foal syndrome in horsesE M Santschi
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
Mamm Genome 9:306-9. 1998..All but one of the parents also had an overo white body-spot phenotype. Solid-colored control horses of other breeds were homozygous for the Ile118 EDNRB allele...
- Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other speciesKevin Keel
Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
J Clin Microbiol 45:1963-4. 2007..Porcine isolates comprised four PCR ribotypes, but one, ribotype 078, predominated (83%). This was also the most common ribotype (94%) among 33 calf isolates but was rarely identified in other species...
- Equine herpesvirus-1 consensus statementD P Lunn
Department of Clinical Sciences, James L Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1620, USA
J Vet Intern Med 23:450-61. 2009..years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry...
- Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendonsRachael L Stanley
Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, Hertfordshire, UK
J Anat 211:325-34. 2007..Tenocytes in the superficial digital flexor tendon of adult horses appear to have limited ability to respond adaptively to exercise or prevent the accumulation of strain-induced ..
- Activated platelet-derived growth factor beta receptor expression, PI3K-AKT pathway molecular analysis, and transforming signals in equine sarcoidsG Borzacchiello
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1 80137, Naples, Italy
Vet Pathol 46:589-97. 2009The equine sarcoid is the most common dermatologic neoplasm reported in horses. Bovine papillomavirus (BPV) types 1 and 2 are associated with sarcoids, in which the expression of the major transforming oncoprotein (E5) is often recorded...
- Exon skipping in the KIT gene causes a Sabino spotting pattern in horsesSamantha A Brooks
Department of Veterinary Science, 108 Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546 0099, USA
Mamm Genome 16:893-902. 2005..In this article we report the genetic basis of one type of Sabino spotting pattern in horses that we call Sabino 1, with the alleles represented by the symbols SB1 and sb1...
- Microsatellite diversity, population subdivision and gene flow in the Lipizzan horseR Achmann
Ludwig Boltzmann Institut für immuno, zyto and molekulargenetische Forschung, Veterinarplatz 1, A 1210 Wien, Austria
Anim Genet 35:285-92. 2004Blood samples of 561 Lipizzan horses from subpopulations (studs) of seven European countries representing a large fraction of the breed's population were used to examine the genetic diversity, population subdivision and gene flow in the ..
- Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)S Rieder
Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, INRA Centre de Recherche de Jouy, 78352 Jouy en Josas Cedex, France
Mamm Genome 12:450-5. 2001..The coding sequences and parts of the flanking regions of those genes were systematically analyzed in 40 horses and mutations typed in a total of 120 horses...
- Sequence heterogeneity in the 18S rRNA gene within Theileria equi and Babesia caballi from horses in South AfricaRaksha Bhoora
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
Vet Parasitol 159:112-20. 2009..survey of the protozoal parasites that cause equine piroplasmosis was conducted using samples collected from horses and zebra from different geographical locations in South Africa...
- Genetic variability in Hanoverian warmblood horses using pedigree analysisH Hamann
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
J Anim Sci 86:1503-13. 2008A data set constituting a total of 310,109 Hanoverian warmblood horses was analyzed to ascertain the genetic variability, coefficients of inbreeding, and gene contributions of foreign populations...
- Staphylococcus aureus colonization in healthy horses in Atlantic CanadaShelly Burton
Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, Prince Edward Island C1A 4P3
Can Vet J 49:797-9. 2008Methicillin-resistant Staphylococcus aureus (MRSA) colonization was not identified in any of 497 horses from Atlantic Canada. Methicillin-susceptible S. aureus (MSSA) was isolated from a subsample of 19/242 (7.9%) horses...
- A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?C T Thorpe
University College London, Division of Surgery and Interventional Science, Institute of Orthopaedics and Musculoskeletal Science, Stanmore Campus, Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP
Equine Vet J 42:174-80. 2010..An understanding of the mechanisms leading to matrix degeneration and subsequent tendon gross failure is the key to developing appropriate treatment and preventative measures...
- Genome-wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infectionYun Young Go
Maxwell H Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
J Virol 85:13174-84. 2011Previously, we have shown that horses could be divided into susceptible and resistant groups based on an in vitro assay using dual-color flow cytometric analysis of CD3+ T cells infected with equine arteritis virus (EAV)...
- Fatal encephalitis due to novel paramyxovirus transmitted from horsesJ D O'Sullivan
Department of Neurology, Royal Brisbane Hospital, Herston, Queensland, Australia
Lancet 349:93-5. 1997In September, 1994, an outbreak of severe respiratory disease affected 18 horses, their trainer, and a stablehand in Queensland, Australia. Fourteen horses and one human being died...
- Population studies of 17 equine STR for forensic and phylogenetic analysisL H P van de Goor
Dr van Haeringen Laboratorium BV, Agro Business Park 100, Wageningen, The Netherlands
Anim Genet 42:627-33. 2011As a consequence of the close integration of horses into human society, equine DNA analysis has become relevant for forensic purposes...
- Evolution of multidrug-resistant Staphylococcus aureus infections in horses and colonized personnel in an equine clinic between 2005 and 2010Sandra Sieber
Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland
Microb Drug Resist 17:471-8. 2011A total of 70 Staphylococcus aureus isolates from postoperative infections in hospitalized horses were isolated between January 2005 and January 2011. Among them, 12 isolates were methicillin-susceptible S...
- A massively parallel sequencing approach uncovers ancient origins and high genetic variability of endangered Przewalski's horsesHiroki Goto
Department of Biology, The Pennsylvania State University, USA
Genome Biol Evol 3:1096-106. 2011..Studies of DNA diversity within Przewalski's horses have been sparse but are urgently needed to ensure their successful reintroduction to the wild...
- A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human kneeD D Frisbie
Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
Vet Comp Orthop Traumatol 19:142-6. 2006..7-1.5 mm for goat and 1.5-2 mm for horse. The horse provides the closest approximation to humans in terms of articular cartilage thickness, and this approximation is considered relevant in pre-clinical studies of cartilage healing...
- Human cases of methicillin-resistant Staphylococcus aureus CC398, FinlandSaara Salmenlinna
National Institute for Health and Welfare, Department of Infectious Disease Surveillance and Control, Helsinki, Finland
Emerg Infect Dis 16:1626-9. 2010..These findings may indicate unrecognized community transmission...
- Genetic diversity and admixture among Canadian, Mountain and Moorland and Nordic pony populationsJ M Prystupa
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A8, Canada
Animal 6:19-30. 2012..Information gathered from this study should be combined with other available phenotypic and pedigree data to develop, or amend, a suitable conservation strategy for all populations examined...
- Serology-enabled discovery of genetically diverse hepaciviruses in a new hostPeter D Burbelo
Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:6171-8. 2012..Thirty-six samples from 103 horses were immunoreactive, and viral genomic RNA was present in 8 of the 36 seropositive animals and none of the ..
- Mapping of equine cerebellar abiotrophy to ECA2 and identification of a potential causative mutation affecting expression of MUTYHLeah S Brault
Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
Genomics 97:121-9. 2011Equine Cerebellar Abiotrophy (CA) is a neurological disease found in Arabian horses. CA is characterized by post-natal degeneration of the Purkinje cells of the cerebellum...
- Glycoprotein C of equine herpesvirus 4 plays a role in viral binding to cell surface heparan sulfateWalid Azab
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Virus Res 151:1-9. 2010..These results suggest that, like other herpesviruses, EHV-4 gC plays a role in the interaction of the virus with cellular heparan sulfate. Moreover, gC can protect the virus from complement-mediated neutralization...
- Equine piroplasmosis associated with Amblyomma cajennense Ticks, Texas, USAGlen A Scoles
US Department of Agriculture and Washington State University, Pullman, Washington, USA
Emerg Infect Dis 17:1903-5. 2011..Infection prevalence reached 100% in some areas (292 infected horses)...
- Risk factors to tick infestations and their occurrence on horses in the state of São Paulo, BrazilM B Labruna
Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Orlando Marques de Paiva, 87 Cidade Universitária, SP 05508 000, Sao Paulo, Brazil
Vet Parasitol 97:1-14. 2001..During visits to farms, horses reared under grazing conditions were examined for the presence of ticks...
- Identification of copy number variants in horsesRyan Doan
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Genome Res 22:899-907. 2012..However, the occurrence of CNVs in horses and their subsequent impact on phenotypic variation is unknown...
- Does work affect personality? A study in horsesMartine Hausberger
Universite de Rennes 1, UMR 6552 Ethologie Animale et Humaine, Unité Mixte de Recherche CNRS, Campus de Beaulieu, Rennes, France
PLoS ONE 6:e14659. 2011..This study investigates this relationship by comparing the emotional reactivity of horses that differed only by their type of work...
- Outbreak of equine piroplasmosis in FloridaMichael A Short
Division of Animal Industry, Florida Department of Agriculture and Consumer Services, 407 S Calhoun St, Mayo Building, Tallahassee, FL 32399, USA
J Am Vet Med Assoc 240:588-95. 2012..The subsequent investigation included quarantine and testing of potentially exposed horses for B equi and Babesia caballi infections, tick surveillance, and owner-agent interviews.
- Erythrocyte binding preference of 16 subtypes of low pathogenic avian influenza and 2009 pandemic influenza A (H1N1) virusesWitthawat Wiriyarat
Faculty of Veterinary Science, Mahidol University, Nakhonpathom 73170, Thailand
Vet Microbiol 146:346-9. 2010..Moreover, the 2009 pandemic viruses did not agglutinate both horse and chicken erythrocytes. Our study concluded that goose and guinea pig erythrocytes are the best in HA assay for all subtypes of influenza viruses...
- Fecal microbiota of horses in the clinical setting: potential effects of penicillin and general anesthesiaAnne Mette R Grønvold
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
Vet Microbiol 145:366-72. 2010..In horses, the main adverse effect of antimicrobial treatment is colitis...
- Infection of humans and horses by a newly described morbillivirusL A Selvey
Communicable Diseases Branch, Queensland Health, Brisbane
Med J Aust 162:642-5. 1995To describe the clinical and epidemiological features of an outbreak of a viral infection affecting humans and horses.
- Analysis of multiyear studies in horses in Kentucky to ascertain whether counts of eggs and larvae per gram of feces are reliable indicators of numbers of strongyles and ascarids presentM K Nielsen
Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, 5 Højbakkegård Alle, DK 2630 Taastrup, Denmark
Vet Parasitol 174:77-84. 2010..For horses, such information does not exist in the published literature...
- Coat color variation at the beginning of horse domesticationArne Ludwig
Leibniz Institute for Zoo and Wildlife Research, 10252 Berlin, Germany
Science 324:485. 2009..We conclude that it is unlikely that horse domestication substantially predates the occurrence of coat color variation, which was found to begin around the third millennium before the common era...
- West Nile virus lineage 2 as a cause of zoonotic neurological disease in humans and horses in southern AfricaMarietjie Venter
Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
Vector Borne Zoonotic Dis 10:659-64. 2010..To determine whether cases of WNV were being missed in South Africa, horses with fever and neurological disease were investigated...
- A highly sensitive method for the detection and genotyping of West Nile virus by real-time PCRDewald Zaayman
Department of Medical Virology, University of Pretoria, South Africa
J Virol Methods 157:155-60. 2009..To our knowledge, this is the first assay designed for the simultaneous detection and genotyping of WNV by rapid, sensitive real-time PCR which may be implemented in diagnostic and epidemiology laboratories...
- Complement-dependent cytotoxicity assay for differentiating West Nile virus from Japanese encephalitis virus infections in horsesYoko Kitai
Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan
Clin Vaccine Immunol 17:875-8. 2010..CDC) assay was established to measure antibodies to the West Nile virus (WNV) nonstructural protein 1 (NS1) in horses. Sera collected from a WNV-infected horse mediated lysis of WNV NS1-expressing cells in a dose-dependent manner at ..
- Evaluating the effectiveness of early vaccination in the control and eradication of equine influenza--a modelling approachM G Garner
Office of the Chief Veterinary Officer, Department of Agriculture, Fisheries and Forestry, GPO Box 858, 18 Marcus Clarke St, Canberra, ACT 2601, Australia
Prev Vet Med 99:15-27. 2011..not initially used, vaccination became a key element in the eradication program, with approximately 140000 horses vaccinated...
- Isolation rates of meticillin-resistant Staphylococcus aureus in dogs, cats and horses in IrelandY Abbott
Veterinary Sciences Centre, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
Vet Rec 166:451-5. 2010..were conducted to determine isolation rates of meticillin-resistant Staphylococcus aureus (MRSA) in dogs, cats and horses in Ireland...
- Identification of protein tyrosine phosphatases and dual-specificity phosphatases in mammalian spermatozoa and their role in sperm motility and protein tyrosine phosphorylationL Gonzalez-Fernandez
Cell Physiology Research Group, Laboratory of Spermatology, University of Extremadura, Caceres, Spain
Biol Reprod 80:1239-52. 2009..Finally, PTP activity has a positive role in the regulation of motility and is involved in protein tyrosine phosphorylation in mammalian sperm...
- Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendonsLauren V Schnabel
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 27:1392-8. 2009..Ultrasound examinations were performed at t = 0, 2, 4, 6, and 8 weeks. Horses were euthanized at 8 weeks and SDFTs were mechanically tested to failure and evaluated for biochemical composition ..
- Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVaCatherine Walsh
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
J Immunol 181:1245-54. 2008....
- Allelic heterogeneity at the equine KIT locus in dominant white (W) horsesBianca Haase
Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland
PLoS Genet 3:e195. 2007White coat color has been a highly valued trait in horses for at least 2,000 years. Dominant white (W) is one of several known depigmentation phenotypes in horses...
- A glycosylated peptide in the West Nile virus envelope protein is immunogenic during equine infectionJody Hobson-Peters
School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
J Gen Virol 89:3063-72. 2008..envelope (E) protein, we identified a continuous (linear) epitope that was immunogenic during WNV infection of horses. Using synthetic peptides, this epitope was mapped to a 19 aa sequence (WN19: E147-165) encompassing the WNV NY99 ..
- The equine influenza epidemic in Australia: spatial and temporal descriptive analyses of a large propagating epidemicBrendan Cowled
Office of the Chief Veterinary Officer, Department of Agriculture, Fisheries and Forestry, GPO Box 858, Canberra, ACT 2601, Australia
Prev Vet Med 92:60-70. 2009..04 versus 1.99), cumulative incidence (27.4 versus 26.9) and incidence rates (1.36 versus 1.54) were similar. The relative impact of vaccination and national movement restrictions in controlling this epidemic needs further investigation...
- Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometryStefanie M Hauck
Department of Protein Science, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
Mol Cell Proteomics 9:2292-305. 2010....
- A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse modelJavier Castillo-Olivares
Institute for Animal Health, Pirbright, Woking, Surrey, United Kingdom
PLoS ONE 6:e16503. 2011..However, ethical and financial considerations, relating to the use of infected horses in high biosecurity installations, have made progress very slow...
- Origin and history of mitochondrial DNA lineages in domestic horsesMichael Cieslak
Leibniz Institute for Zoo and Wildlife Research, Evolutionary Genetics, Berlin, Germany
PLoS ONE 5:e15311. 2010Domestic horses represent a genetic paradox: although they have the greatest number of maternal lineages (mtDNA) of all domestic species, their paternal lineages are extremely homogeneous on the Y-chromosome...
- Transmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and catsM M Williamson
CSIRO, Australian Animal Health Laboratory, Geelong, Victoria
Aust Vet J 76:813-8. 1998..To determine the infectivity and transmissibility of Hendra virus (HeV)...
- The prevalence of methicillin-resistant staphylococci in healthy horses in the NetherlandsJ F Busscher
Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
Vet Microbiol 113:131-6. 2006Two hundred healthy horses housed at 23 different farms and one clinic and 42 persons in close contact with these horses were screened for the presence of methicillin resistant staphylococci...
- The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARsT Raudsepp
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
Cytogenet Genome Res 121:102-9. 2008..Although striking differences like those observed between human and mouse may be rare, variations similar to those seen between horse and human may be prevalent among mammals...
- Genetic diversity among horse populations with a special focus on the Franches-Montagnes breedM L Glowatzki-Mullis
Institute of Animal Genetics, Nutrition and Housing, Vetsuisse Faculty, University of Berne, CH 3001 Berne, Switzerland
Anim Genet 37:33-9. 2006..increase in the number of homozygous loci with increasing inbreeding could not be shown for the Franches-Montagnes horses. The proportion of shared alleles, combined with the neighbour-joining method, defined clusters for Icelandic ..
- The earliest horse harnessing and milkingAlan K Outram
Department of Archaeology, University of Exeter, Exeter, EX4 4QE, UK
Science 323:1332-5. 2009..C.E. Metrical analysis of horse metacarpals shows that Botai horses resemble Bronze Age domestic horses rather than Paleolithic wild horses from the same region...
- Major histocompatibility complex variation in the endangered Przewalski's horseP W Hedrick
Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
Genetics 152:1701-10. 1999..In examining 14 Przewalski's horses that are broadly representative of the living animals, we found six different class II DRB major ..
- Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cellsMartin A Vidal
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Vet Surg 36:613-22. 2007..To characterize equine adipose tissue-derived stromal cell (ASC) frequency and growth characteristics and assess of their adipogenic and osteogenic differentiation potential...
- Pathogenesis of Subtype IE Venezuelan Equine Encephalitis VirusALISON PAIGE ADAMS; Fiscal Year: 2012..Major epidemics in humans only occur when VEEV replicates to high titers in the blood of infected horses, donkeys, and mules, which is then transmitted to humans by infected mosquitoes...
- HIV and CD16+ monocytes as cellular reservoir &HIV/pulmonary hypertensionSharilyn Almodovar; Fiscal Year: 2013..Peripheral blood CD16+ monocytes in HIV-infected patients serve as Trojan horses for these specific HIV quasispecies...
- The Evolutionary and Biological Bases of Host Switching in VirusesColin R Parrish; Fiscal Year: 2013..Although H3N8 EIV first emerged in horses from birds in 1963, only in the last ~10 years has it jumped to dogs, and on multiple occasions...
- Crosslink augmentation to resist snoring and obstructive sleep apnea syndromeThomas P Hedman; Fiscal Year: 2013..4) safety and treatment effect will be evaluated in pilot studies involving treatment of soft palats in normal horses and horses diagnosed with dorsal displacement of the soft palate (DDSP) which involves a form of awake snoring and ..
- Multicenter Cartilage Repair Preclinical Trial in HorsesConstance R Chu; Fiscal Year: 2010..The potential impact of this proposal on generating long-term improvements to public health and eventual reduction in health care related costs from joint pain and osteoarthritis are major. ..
- POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATIONHarvinder Singh Gill; Fiscal Year: 2012..We propose to exploit these fantastic natural particles and transform them into [unreadable]Trojan horses[unreadable] to safely ferry vaccine antigens across the harsh environment of the stomach and across the tight ..
- Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysisJulie M Barkmeier-Kraemer; Fiscal Year: 2013..Previous work studying idiopathic onset of UVP in horses suggested that chronic compression to the RLN occurred near the aortic arch or inferior trachea...
- Pulmonary innate immunity and pathogens of the order ActinomycetalesTracy K Carlson; Fiscal Year: 2012..AIDS) patients as well as being an important cause of economic loss and morbidity as a disease of young horses. Defining and modulating the interaction of the pulmonary environment with these pathogens will open new avenues ..
- A Cell-Based HTS to Discover Molecules that Inhibit VEEV ReplicationDONGHOON CHUNG; Fiscal Year: 2012..In general, disease is rare in US however epizootic strains of VEEV infected horses and approximately 70,000 ~ 100,000 people in South America in last epidemics in 1995 - 1996...
- TRP channel expression and function in ON-bipolar cellsRobert M Duvoisin; Fiscal Year: 2012..Recently, it has been reported that CSNB in Appaloosa horses is associated with a mutation causing a reduced expression of the TRPM1 cation channel...
- Allogeneic Placental Stem Cells for Tissue Repair and RegenerationVijay Kumar; Fiscal Year: 2010..In collaboration with the UC Davis Center for Equine Health and UC Davis, we will use horses as a non-terminal, large animal model to explore the feasibility of banking autologous and allogeneic equine ..
- Fat Dogs and Coughing Horses: Animal Contributions towards a Healthier CitizenryTimothy L Ratliff; Fiscal Year: 2013....
- Nipah &Hendra Virus Nonhuman Primate Model &Therapeutics DevelopmentTHOMAS WILLIAM GEISBERT; Fiscal Year: 2013..Hendra appeared in Australia in 1994 and was transmitted to humans from infected horses;Nipah appeared in1998 in Malaysia and was passed from infected pigs to humans, but several animal species were ..
- The Molecular Basis of VEEV PathogenesisILYA V FROLOV; Fiscal Year: 2012..in the US, because they continuously circulate in nature and have the ability to cause fatal disease in humans and horses. In addition, EEEV, WEEV and, in particular, VEEV have the potential for use by terrorists and as biological ..
- Vaccines and Therapeutics for Nipah and Hendra virusChristopher Broder; Fiscal Year: 2012..HeV appeared first in Australia in 1994 and was transmitted to humans from infected horses;NiV appeared in 1998-99 in Malaysia and was predominantly passed from infected pigs to humans, but several animal ..
- Development of Pulmonary Immunocompetency: Focus on the NeonateBRETT ALAN SPONSELLER; Fiscal Year: 2010..tested by pursuing two specific aims: 1) Determine the extent to which macrophages from neonatal foals and adult horses produce reactive oxygen and nitrogen species...
- Strategies of lentivirus persistenceSusan Carpenter; Fiscal Year: 2012..Retrospective samples isolated from EIAV-infected horses at sequential stages of disease will be used to test the hypothesis that virus variants which successfully evade a ..
- Regulation of glycogen metabolism: Insights from novel genetic modelsMolly E McCue; Fiscal Year: 2013..a gain of function mutation in the GYS1 gene encoding the skeletal muscle is form of glycogen synthase in horses with PSSM, which results in an amino acid substitution in a highly conserved region of the enzyme...
- Generation of therapeutic antibodies to serotype F botulismJames D Marks; Fiscal Year: 2013..The mainstay of treatment is equine antitoxin, made by hyperimmunizing horses. Equine antitoxin has a reduced potency for sub-serotypes, a significant incidence of allergic reactions, a short ..
- Multiple functions of VEEV nsP3 in virus replicationElena I Frolova; Fiscal Year: 2011..South and North Americas and have the ability to cause encephalitis with frequent fatal outcomes in humans and horses. We have recently demonstrated that the Old World and the New World alphaviruses differ not only in the severity ..
- Immunotherapeutics for Treatment of Flavivirus InfectionErol Fikrig; Fiscal Year: 2010..appearance in the United States in 1999, West Nile virus (WNV) has caused the deaths of large numbers of birds and horses and close to 1000 humans...
- Epigenetics: A Novel Approach in Primary ImmunodeficienciesMARIA JULIA BEVILAQUA FELIPPE; Fiscal Year: 2010..Public Health Relevance: Common variable immunodeficiency (CVID) in horses is a primary humoral immunodeficiency characterized by late-onset recurrent bacterial infections, hypo- or ..
- Role of Pattern Recognition Receptors in Protection Against Influenza VirusBalaji Manicassamy; Fiscal Year: 2011..Influenza A virus can also infect a variety of other species including poultry, aquatic birds, horses, pigs and seals...
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2011..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the ..
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2013..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the ..
- STANDARD ANIMAL MODEL FOR ARTICULAR CARTILAGE REPAIRAnthony Ratcliffe; Fiscal Year: 2013..models for articular cartilage repair and regeneration, ranging from rodents to very large animals including horses. There are a large number of different analyses that can be performed used as outcome measures...
- Role of Pattern Recognition Receptors in Protection Against Influenza VirusBalaji Manicassamy; Fiscal Year: 2013..Influenza A virus can also infect a variety of other species including poultry, aquatic birds, horses, pigs and seals...
- Analysis of HCMV Infection of Monocytes and MacrophagesAndrew D Yurochko; Fiscal Year: 2013..How does HCMV influence monocyte function and force the infected monocyte to serve as Trojan Horses for hematogenous spread? Our new data show that viral binding is the key biological trigger for the changes in ..
- Mucosal Vector with TLR3 agonist for protection against VEESean N Tucker; Fiscal Year: 2010..attenuated VEE vaccines have been tested, including a strain called TC-83, which is currently licensed for use in horses. However, these vaccines are too dangerous for human use or face a difficult regulatory approval process because ..
- MUSCULOSKELETAL STIFFNESS AND LOCOMOTIONCLAIRE FARLEY; Fiscal Year: 2000..like a single linear spring in all of the mammals studied to date, including running humans, trotting dogs and horses, and hopping kangaroos...
- A Standard Animal Model for Articular Cartilage RepairAnthony Ratcliffe; Fiscal Year: 2010..models for articular cartilage repair and regeneration, ranging from rodents to very large animals including horses. There are a large number of different analyses that can be performed used as outcome measures...
- Promoting Healing of Tendinopathies Using Therapeutic Mechanobiologic StimulationVincent M Wang; Fiscal Year: 2013..This pathway has emerged from studies on equine tendinopathy in a susceptible breed of horses. We are pursuing mechanistic studies in wild type and ADAMTS5-deficient mice which exhibit tendon changes (..
- Cellular trafficking of B-amyloid seedsAMARALLYS FRANCESCA CINTRON; Fiscal Year: 2013..This proposal will test the hypothesis that macrophages and neurons act as cellular Trojan horses by introducing pathogenic protein seeds into distant sites, where they mediate the subsequent emergence of lesions...
- EPITOPES RECOGNIZED BY CTL FROM EIAV CARRIER HORSESSHERITTA RIDGELY; Fiscal Year: 2000..The control of clinical disease in horses and the maintenance of the inapparent carrier state during persistent infection with EIAV makes this an attractive ..
- MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASEMady Hornig; Fiscal Year: 2002..Natural infection has been confirmed only in horses, sheep, cattle, birds, and cats; however, primates can be infected experimentally...
- Regulation of Burkholderia mallei virulence genesWilliam Nierman; Fiscal Year: 2005..provided by the applicant): Burkholderia mallei, the etiologic agent of glanders, is an obligate parasite of horses, mules and donkeys, and is classified as a Category B agent by the Centers for Disease Control and Prevention (CDC)..
- 26th Intl Herpesvirus Workshop, Regensburg, GermanyJay Nelson; Fiscal Year: 2001..to the poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
- 25TH INTERNATIONAL HERPESVIRUS WORKSHOPJay Nelson; Fiscal Year: 2000..to the poultry (Marek s and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
- International Herpesvirus Workshop, Cairns, AustraliaJay Nelson; Fiscal Year: 2002..to the poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
- Fourth Symposium Biology Vertebrate Sex DeterminationBlanche Capel; Fiscal Year: 2006..and is attended by scientists working on diverse vertebrate systems including fish, birds, reptiles, pigs, goats, horses, mice, marsupials, and humans...
- MOLECULAR EVOLUTION IN MAMMALSCHARLES SIBLEY; Fiscal Year: 1992..3. To initiate a study of the ungulates (horses, swine, hippos, rhinos, camels, giraffe, deer, cattle, antelopes) whose good fossil record should permit ..
- ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASEMichael Davis; Fiscal Year: 2004..Specifically, dogs and horses will perform strenuous treadmill exercise while breathing frigid air and pulmonary resistance, reactivity, and a ..
- Emergence and adaption of West Nile virus in New YorkLaura Kramer; Fiscal Year: 2006..The virus was first identified in the Western Hemisphere in 1999 when humans, mosquitoes, birds and horses in a limited area near New York City were found infected...
- REGULATION OF MHC GENES IN TROPHOBLASTDOUGLAS ANTCZAK; Fiscal Year: 1999..In addition, horses of defined MHC haplotypes, including homozygotes, are available for experimental matings...
- A novel model for the study of primary immunodeficiency: the equine CVIDMARIA FLAMINIO; Fiscal Year: 2009DESCRIPTION (provided by applicant): Common variable immunodeficiency (CVID) in horses is a natural primary immunologic condition characterized by late-onset B cell lymphopenia or depletion, hypo- or agammaglobulinemia, and recurrent ..
- Nipah virus and Hendra virus Peptide TherapeuticsChristopher Broder; Fiscal Year: 2006..HeV was identified first and isolated from cases of severe respiratory disease that fatally affected both horses and man...
- 24TH INTERNATIONAL HERPESVIRUS WORKSHOPFrederick Wang; Fiscal Year: 1999..to the poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses...
- Ecology of Encephalitis Viruses in the USAThomas R Unnasch; Fiscal Year: 2010..the virus, the development of avian enzootics and the escape of the virus from enzootic foci to infect humans and horses. The specific aims of the project are: 1...
- PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSISUlrike Munderloh; Fiscal Year: 2001..Diagnosis has been difficult and serologic testing, using leukocytes from horses infected with the related Ehrlichia equi, is insensitive at presentation...
- FIFTH INTERNATIONAL SYMPOSIUM ON THE BIOLOGY OF VERTEBRATE SEX DETERMINATIONRichard Behringer; Fiscal Year: 2009..including amphibians, fish, birds, reptiles, monotremes, marsupials, and eutherian mammals, including pigs, goats, horses, mice, and humans...
- Generation of a Single-Cycle Virus to Study the Pathogenesis of Nipah VirusMARK PEEPLES; Fiscal Year: 2007..of this outbreak was identified as Nipah virus (NiV), a relative of Hendra virus that had recently emerged in horses and humans in Australia...
- COMPARATIVE STUDIES OF PREGNANCY AND HISTOCOMPATIBILITYDOUGLAS ANTCZAK; Fiscal Year: 2000..We propose to study horses, donkeys, and their interspecies hybrids because the strong maternal anti-fetal immune responses mounted during ..
- Development of Medical Countermeasures to Ricin PoisoningTHOR BORGFORD; Fiscal Year: 2009..Develop the first fully human anti-ricin antibody therapy. In our first approach, horses will be immunized with recombinant TST10088 to elicit an anti-ricin immune response...
- A MODEL OF BRONCHIAL HYPERREACTIVITYN Robinson; Fiscal Year: 1990..b>Horses and ponies with chronic airway disease develop acute exacerbations of disease when housed in a barn...
- ASSAY TO RAPIDLY DETECT ENDOTOXIN IN WHOLE BLOODNathan Smith; Fiscal Year: 1991..In preliminary studies, the assay has been shown to correlate with clinical suspicion of endotoxemia in horses hospitalized with symptomatic colic...
- ADOPTIVE TRANSFER OF CD8+ CTLS TO CONTROL EIAVROBERT MEALEY; Fiscal Year: 2001..The long-term goal of this research is to define the role of CTLs in the control of EIAV, a lentivirus of horses which cause a persistent infection characterized by recurrent episodes of viremia with concurrent fever, ..
- Recombinant Adenoviral Vector with Encoded TLR3 Ligand for Protection Against VEESean Tucker; Fiscal Year: 2009..the purpose of creating a prophylactic vaccine, including a strain called TC-83 which has been licensed for use in horses. However, these attenuated strains have either proven to be too dangerous to use in humans or have a difficult ..
- TRANSCRIPTION IN HERPESVIRUS INFECTED CELLSJohn Staczek; Fiscal Year: 1990..of pregnant mares, and equine herpesvirus type 2 (equine cytomegalovirus; ECMV) establishes a chronic infection in horses. These two viruses differ in several biological and physical properties: (1) EHV-1 has a highly lytic infection ..
- Acquiring Number Word Semantics: A Syntactic Bootstrapping ApproachKRISTEN L SYRETT; Fiscal Year: 2010..g., 'zav of the horses'must be about a quantity of horses, while 'very zav horses'cannot be)...
- Cytotoxic T Lymphocytes in immunity to Rhodococcus equiKRISTIN HASEL; Fiscal Year: 2003..The proposed research will test the hypothesis that intrabronchial R equi challenge of immune horses stimulates intrapulmonary CD8+ cytotoxic T lymphocytes specific for secreted proteins encoded by the virulence ..
- Inhibitors of HIV-Dendritic Cell Interactions as MicrobicidesPHILIPPE ANDRE GALLAY; Fiscal Year: 2011..crosses the genital epithelium in the absence of lesions, it is likely that HIV hijacks host cells as Trojan horses to cross the normally impermeable genital epithelium...
- Shonga Ska: Sacred Horse Society Drug Prevention ProgramLESLIE WHITBECK; Fiscal Year: 2006..This traditional bond between horses and humans is the perfect medium for communicating cultural values and beliefs regarding honor, courage, dignity, ..
- OVARIAN FUNCTION IN MARES CHRONICALLY TREATED WITH PZPJay Kirkpatrick; Fiscal Year: 1992..The use of urinary steroid metabolites to monitor ovarian function will preclude the need to capture or handle horses.