Summary: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Top Publications

  1. pmc Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits
    Javier Márquez-Ruiz
    Division of Neurosciences, Pablo de Olavide University, 41013 Seville, Spain
    Proc Natl Acad Sci U S A 109:6710-5. 2012
  2. ncbi Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 220:640-6. 2001
  3. ncbi The nature of the globular- to fibrous-actin transition
    Toshiro Oda
    X ray Structural Analysis Research Team, RIKEN SPring 8 Center, RIKEN Harima Institute, 1 1 1, Kouto, Sayo, Hyogo 679 5148, Japan
    Nature 457:441-5. 2009
  4. ncbi Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
  5. pmc Urease as a virulence factor in experimental cryptococcosis
    G M Cox
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 68:443-8. 2000
  6. ncbi Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
    Arjan B Te Pas
    Neonatal Services, Royal Women s Hospital, Parkville, Victoria 3053, Australia
    Pediatr Res 66:295-300. 2009
  7. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
  8. pmc The genetic structure of domestic rabbits
    Miguel Carneiro
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Campus Agrário de Vairão, Vairao, Portugal
    Mol Biol Evol 28:1801-16. 2011
  9. ncbi Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure
    Hester M den Ruijter
    Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Room K2 113, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 117:536-44. 2008
  10. pmc Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains
    Min Li
    Department of Laboratory Medicine, Huashan Hospital, Shanghai 200040, People s Republic of China
    J Infect Dis 202:1866-76. 2010

Detail Information

Publications330 found, 100 shown here

  1. pmc Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits
    Javier Márquez-Ruiz
    Division of Neurosciences, Pablo de Olavide University, 41013 Seville, Spain
    Proc Natl Acad Sci U S A 109:6710-5. 2012
    ..Here we show in behaving rabbits that tDCS applied over the somatosensory cortex modulates cortical processes consequent to localized stimulation ..
  2. ncbi Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 220:640-6. 2001
    ..To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to monitor this procedure...
  3. ncbi The nature of the globular- to fibrous-actin transition
    Toshiro Oda
    X ray Structural Analysis Research Team, RIKEN SPring 8 Center, RIKEN Harima Institute, 1 1 1, Kouto, Sayo, Hyogo 679 5148, Japan
    Nature 457:441-5. 2009
    ..The flat form is essential for the formation of stable, helical F-actin. Our F-actin structure model provides the basis for understanding actin polymerization as well as its molecular interactions with actin-binding proteins...
  4. ncbi Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
    ..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...
  5. pmc Urease as a virulence factor in experimental cryptococcosis
    G M Cox
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 68:443-8. 2000
    ..Comparison of a ure1 mutant with H99 after intracisternal inoculation into corticosteroid-treated rabbits revealed no significant differences in colony counts recovered from the cerebrospinal fluid...
  6. ncbi Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
    Arjan B Te Pas
    Neonatal Services, Royal Women s Hospital, Parkville, Victoria 3053, Australia
    Pediatr Res 66:295-300. 2009
    ..Preterm rabbits (28 d), randomized into four groups, received a 1-, 5-, 10-, or 20-s inflation (SI) followed by ventilation with ..
  7. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
    ..This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells...
  8. pmc The genetic structure of domestic rabbits
    Miguel Carneiro
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Campus Agrário de Vairão, Vairao, Portugal
    Mol Biol Evol 28:1801-16. 2011
    ..b>Rabbits exhibit exceptional phenotypic diversity, are of great commercial value, and serve as important animal models in ..
  9. ncbi Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure
    Hester M den Ruijter
    Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Room K2 113, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 117:536-44. 2008
    ..We hypothesized that superfusion with omega3-polyunsaturated fatty acids (omega3-PUFAs) from fish inhibits triggered activity in heart failure...
  10. pmc Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains
    Min Li
    Department of Laboratory Medicine, Huashan Hospital, Shanghai 200040, People s Republic of China
    J Infect Dis 202:1866-76. 2010
    ..Here, we analyzed virulence of globally occurring CA-MRSA strains in a rabbit skin infection model. We used rabbits because neutrophils from this animal species have relatively high sensitivity to Panton-Valentine leukocidin (PVL)..
  11. ncbi Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction
    Yejia Song
    Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Rd, M 411, Gainesville, FL 32610 0277, USA
    J Pharmacol Exp Ther 318:214-22. 2006
  12. pmc Magnetic resonance imaging and histopathological study of brain lesions in rabbits given intravenous verotoxin 2
    J Fujii
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Infect Immun 64:5053-60. 1996
    When rabbits were given intravenously purified verotoxin 2 (VT2) at 5 microg/kg of body weight, they developed hemorrhagic diarrhea, flaccid paresis, an ataxic gait, an opisthotonic posture, and convulsions...
  13. ncbi Direct visualization of secondary structures of F-actin by electron cryomicroscopy
    Takashi Fujii
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 467:724-8. 2010
  14. ncbi Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    Nikki Parker
    Endocyte Inc, West Lafayette, IN 47906, USA
    Anal Biochem 338:284-93. 2005
    ..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...
  15. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
    ..pressure by surgical insertion of a fiber optic oxygen probe into granulomas in the lungs of living infected rabbits demonstrated that even small (3-mm) pulmonary lesions were severely hypoxic (1.6 +/- 0.7 mm Hg)...
  16. ncbi Spontaneous activity signatures of morphologically identified interneurons in the vestibulocerebellum
    Tom J H Ruigrok
    Department of Neuroscience, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Neurosci 31:712-24. 2011
    ..The remaining cells were placed into border categories within which no classification was attempted. We propose that this algorithm can be used to help classify vestibulocerebellar interneurons recorded in awake, behaving animals...
  17. ncbi Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection
    Victoria Lewis
    Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
    J Neuropathol Exp Neurol 68:1125-35. 2009
  18. ncbi Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells
    Mariano Janiszewski
    Vascular Biology Laboratory, Heart Institute Instituto do Coração, School of Medicine, University of Sao Paulo, Av Eneas Carvalho Aguiar, 44 subsolo, Sao Paulo, CEP 05403 000 Brazil
    J Biol Chem 280:40813-9. 2005
    ..These results suggest that PDI closely associates with NAD(P)H oxidase and acts as a novel redox-sensitive regulatory protein of such enzyme complex, potentially affecting subunit traffic/assembling...
  19. pmc Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis
    Anthony Lee
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Infect Immun 78:4213-25. 2010
    ..Our findings indicate that the genes required for C. neoformans survival in CSF ex vivo are necessary for survival and infection in this unique host environment...
  20. ncbi Dietary fish oil reduces pacemaker current and heart rate in rabbit
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1485-92. 2009
    ..Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil (FO) reduce heart rate in humans. The mechanism underlying this cardioprotective effect of FO is unknown...
  21. pmc Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e3198. 2008
    ..Following experimental infection of rabbits, an animal species whose granulocytes are more sensitive to the effects of PVL compared with the mouse, we found ..
  22. pmc The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region
    S W Barnett
    Chiron Corporation, Emeryville, California 94608-2916, USA
    J Virol 75:5526-40. 2001
    ..To test this hypothesis, we immunized rabbits and rhesus macaques with the gp140 form of these two envelopes...
  23. ncbi The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
    Ching Chieh Tung
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nature 468:585-8. 2010
  24. ncbi Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
    Anna L Mead
    Wound Healing Unit, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:3394-401. 2003
  25. ncbi Actin filament guidance on a chip: toward high-throughput assays and lab-on-a-chip applications
    Mark Sundberg
    Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 39182 Kalmar, Sweden
    Langmuir 22:7286-95. 2006
    ..The results are discussed in relation to lab-on-a-chip applications and nanotechnology-assisted assays of actomyosin function...
  26. pmc Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits
    Giovanna Ponti
    Department of Veterinary Morphophysiology, University of Turin, Grugliasco, Italy
    PLoS ONE 3:e2366. 2008
    ..Here we investigated what happens in the cerebellar cortex of peripuberal rabbits by using endogenous and exogenously-administered cell proliferation antigens in association with a cohort of ..
  27. ncbi Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus
    Maria J Tunon
    Institute of Biomedicine, University of Leon, Leon, Spain
    J Pineal Res 50:38-45. 2011
    ..b>Rabbits were experimentally infected with 2 × 10(4) hemagglutination units of a RHDV isolate and received melatonin at ..
  28. pmc Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
    Valerio W Valeri
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    Blood 116:3809-17. 2010
    ..that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels...
  29. pmc Histo-blood group antigens act as attachment factors of rabbit hemorrhagic disease virus infection in a virus strain-dependent manner
    Kristina Nyström
    INSERM, U892, Universite de Nantes, Nantes, France
    PLoS Pathog 7:e1002188. 2011
    ..virus (RHDV), a calicivirus of the Lagovirus genus, and responsible for rabbit hemorrhagic disease (RHD), kills rabbits between 48 to 72 hours post infection with mortality rates as high as 50-90%...
  30. ncbi Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Vic, Australia
    Int J Parasitol 39:371-80. 2009
    ..Given its small size, we believe PfRh5 may prove to be a valuable candidate for inclusion in a multi-component anti-malarial vaccine...
  31. ncbi The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China
    Yansheng Geng
    Graduate School of Peking Union Medical College, 9 Dongdansantiao, Beijing 100730, China
    Infect Genet Evol 11:476-82. 2011
    We identified and characterized a novel virus, designated rabbit hepatitis E virus (HEV), in rex rabbits farmed in China...
  32. ncbi Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
    Ibrahim Murat Bolayirli
    Istanbul University, Cerrahpasa Medical Faculty, Fikret Biyal Central Research Laboratory, Istanbul, Turkey
    Life Sci 81:121-7. 2007
    ..nitric oxide(NO) and asymmetric dimethylarginine (ADMA), homocysteine, and paraoxonase activity (PON1) in rabbits. Twenty rabbits fed with high-cholesterol diet for 8 weeks were randomly divided into 2 groups on the fourth week ..
  33. ncbi L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits
    M M Sayed-Ahmed
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Pharmacol Res 44:235-42. 2001
    This study has been initiated to investigate, in hypercholesterolaemic rabbits, whether L-carnitine deficiency could be an additional risk factor in atherosclerosis, and if so, whether L-carnitine supplementation could prevent the ..
  34. ncbi Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits
    Satoshi Akuzawa
    First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Vasc Surg 48:694-700. 2008
    ..Using a rabbit model, we investigated the neuroprotective effects of IL-1 receptor antagonist (IL-1ra) in a temporal fashion...
  35. pmc Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review
    Joana Abrantes
    CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Vet Res 43:12. 2012
    ..RHDV) is a calicivirus of the genus Lagovirus that causes rabbit haemorrhagic disease (RHD) in adult European rabbits (Oryctolagus cuniculus)...
  36. ncbi Low-level laser therapy stimulates bone-implant interaction: an experimental study in rabbits
    Maawan Khadra
    Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Clin Oral Implants Res 15:325-32. 2004
    ..95 mm were implanted into cortical bone in each proximal tibia of twelve New Zealand white female rabbits (n=48). The animals were randomly divided into irradiated and control groups...
  37. pmc Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Res Ther 10:R84. 2008
    ..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
  38. pmc A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates
    Aman Mahajan
    UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biophys J 94:392-410. 2008
  39. pmc Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine
    Arata Honda
    RIKEN BioResource Center, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 285:31362-9. 2010
    ..The rabbit model should enable us to compare iPS cells and embryonic stem cells under the same standardized conditions in evaluating their ultimate feasibility for pluripotent cell-based regenerative medicine in humans...
  40. pmc Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo
    Ajay Sharma
    Harry S Truman Memorial Veterans Hospital, Columbia, MO 65212, USA
    Mol Vis 16:720-8. 2010
  41. pmc Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e8110. 2009
    ..Immunisation of rabbits with a PfAMA1 allele mixture yielded an increased proportion of antibodies to epitopes common to all vaccine ..
  42. ncbi Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells
    Jose Alvaro Pereira Gomes
    Centro Avançado de Superfície Ocular and Setor de Córnea e Doenças Externas, Instituto da Visão, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 51:1408-14. 2010
  43. ncbi Molecular genetic typing reveals further insights into the diversity of animal-associated Staphylococcus aureus
    Davida S Smyth
    University of Dublin, Moyne Institute of Preventive Medicine, Department of Microbiology, School of Genetics and Microbiology, Trinity College, Dublin 2, Ireland
    J Med Microbiol 58:1343-53. 2009
    ..S. aureus isolates recovered from chickens and rabbits were genotypically more similar to known human genotypes than the ruminant-associated lineages.
  44. pmc Long-term storage of surface-adsorbed protein machines
    Nuria Albet-Torres
    School of Natural Sciences, Linnaeus University, SE 39245 Kalmar, Sweden
    Langmuir 27:7108-12. 2011
    ..The results are important to the future commercial implementation of motor-based nanodevices and are of more general value to the long-term storage of any protein-based bionanodevice...
  45. ncbi Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response
    Christian Meltendorf
    Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 48:2068-75. 2007
    ..To examine the corneal repair response after intrastromal femtosecond (fs) laser keratotomy...
  46. pmc Twirling of actin by myosins II and V observed via polarized TIRF in a modified gliding assay
    John F Beausang
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 95:5820-31. 2008
    ..We found that whole myosin II and myosin V both twirl actin with a relatively long (approximately 1 microm), left-handed pitch that is insensitive to myosin concentration, filament length, and filament velocity...
  47. ncbi MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
    J H Hartwig
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 356:618-22. 1992
  48. ncbi Silanized surfaces for in vitro studies of actomyosin function and nanotechnology applications
    Mark Sundberg
    Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 391 82 Kalmar, Sweden
    Anal Biochem 323:127-38. 2003
    ..Furthermore, TMCS derivatized glass also seems to offer several advantages over nitrocellulose for HMM adsorption in the ordinary in vitro motility assay...
  49. ncbi Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits
    Komal Mehta
    Department of Pharmacy, Faculty of Technology and Engineering, The M S University of Baroda, Kalabhavan, Gujarat, India
    J Ethnopharmacol 86:191-5. 2003
    b>Rabbits were fed Moringa oleifera (200mg/kg/day, p.o.) or lovastatin (6mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days...
  50. ncbi Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits
    Yen Bin Liu
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University School of Medicine, Taiwan, Republic of China
    Circ Res 92:1145-52. 2003
    ..We fed rabbits with either high cholesterol (HC, n=10) or standard (S, n=10) chows for 12 weeks (protocol 1), and with HC (n=12) ..
  51. ncbi A subpial, transitory germinal zone forms chains of neuronal precursors in the rabbit cerebellum
    Giovanna Ponti
    Department of Veterinary Morphophysiology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Italy
    Dev Biol 294:168-80. 2006
    ..Here, we show the protracted genesis of newly generated neuronal precursors in the cerebellar cortex of young rabbits, persisting beyond puberty...
  52. ncbi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
    ..However, the CDHA scaffolds showed as good biocompatibility and osteogenicity as the hybrid ones at 8 weeks. These results indicate that the CDHA scaffolds fulfill the basic requirements of bone tissue engineering scaffold...
  53. pmc Comparing antigenicity and immunogenicity of engineered gp120
    Suganya Selvarajah
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 79:12148-63. 2005
    ..The work presented here describes the immune response in rabbits immunized with two prototype, engineered gp120s to explore the relationship between antigenicity and ..
  54. pmc Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen
    Cassian Sitaru
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Clin Invest 115:870-8. 2005
    ..This animal model for EBA should facilitate further dissection of the pathogenesis of this disease and development of new therapeutic strategies...
  55. pmc Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations
    Fan Bai
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA
    Biophys J 100:1014-23. 2011
    ..Decreased contractility (T(act)) in V95A and D175N may further contribute to the severity of myocyte hypertrophy and related prognosis of the disease...
  56. ncbi Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts
    Vadim V Fedorov
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130 4899, USA
    Heart Rhythm 4:619-26. 2007
    ..Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects of currently available pharmacologic excitation-contraction uncoupling agents...
  57. ncbi The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
    Serdar Gunaydin
    Department of Pediatric Cardiac Surgery, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Cardiovasc Surg 10:138-45. 2002
    ..We studied in vivo effects in monocrotaline induced pulmonary hypertensive rabbits immediately after cardiopulmonary bypass (CPB) and tested them versus calcium channel and beta-blockers.
  58. ncbi Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits
    Hiroyuki Nomoto
    Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 50:4807-13. 2009
    To investigate the pharmacokinetics of bevacizumab in rabbits for three different routes of administrations: intravitreal injection, subconjunctival injection, and eye drops.
  59. pmc A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challenge
    Nehal Mohamed
    Elusys Therapeutics Inc, P O Box 102, 25 Riverside Drive, Pine Brook, NJ 07058, USA
    Infect Immun 73:795-802. 2005
    ..5 and 10 mg per animal significantly protected rabbits from a lethal aerosolized anthrax spore challenge ( approximately 60 to 450 times the 50% lethal dose of Bacillus ..
  60. pmc Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women
    Mirja Hommel
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 78:1963-78. 2010
    ..Inclusion of a limited number of variants in a candidate vaccine may be sufficient for broad population coverage, but geographic considerations may also have to be included in vaccine design...
  61. pmc Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute PHRI at the University of Medicine and Dentistry of New Jersey UMDNJ, Newark, New Jersey, United States of America
    PLoS Pathog 7:e1002262. 2011
    ..production by increasing intracellular cAMP in macrophages, to examine the crosstalk between host and pathogen in rabbits with pulmonary TB during treatment with isoniazid (INH)...
  62. pmc Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice
    Hirotaka Hiyoshi
    Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Infect Immun 78:1772-80. 2010
    ..Our findings provide new indications that these virulence factors contribute to and orchestrate each distinct aspect of the pathogenicity of V. parahaemolyticus...
  63. ncbi Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 333:207-15. 2008
    ..MSCs were isolated from bone marrow, synovium, adipose tissue, and muscle of adult rabbits. Proliferation potential and in vitro chondrogenic potential were compared...
  64. pmc Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection
    David Smajs
    Human Genome Sequencing Center, University of Texas Houston Medical School, Houston, Texas, USA
    J Bacteriol 187:1866-74. 2005
    ..pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T...
  65. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
    ..Mesenchymal stem cells (MSCs) derived from bone marrow of neonatal rabbits were cultured, expanded and seeded on n-HA/PA scaffolds...
  66. ncbi MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 31:1527-37. 2005
    ..Pulsed ultrasound exposures (sonications) were performed in the brains of 24 rabbits under monitoring by magnetic resonance imaging (MRI) (ultrasound: frequency = 1...
  67. pmc Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines
    Christina Schellenbacher
    Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria
    J Virol 83:10085-95. 2009
    ..Except for chimeras 35-75 and 13-107, recombinant fusion proteins assembled into VLP. Vaccination of rabbits with Freund's adjuvanted native VLP induced higher L2-specific antibody titers than vaccination with ..
  68. ncbi Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 108:2270-4. 2003
    ..The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to plaque instability, however, cannot be detected directly with any current diagnostic modality...
  69. pmc Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
    Xingmin Feng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3675-83. 2008
    ..The therapeutic effects of rATG may occur not only because of lymphocyte depletion but also enhanced Treg cell number and function...
  70. ncbi Association of triadin with the ryanodine receptor and calsequestrin in the lumen of the sarcoplasmic reticulum
    W Guo
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242, USA
    J Biol Chem 270:9027-30. 1995
  71. pmc Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
    W Palinski
    Department of Medicine, University of California, San Diego 92093, USA
    J Clin Invest 98:800-14. 1996
    ..The availability of "natural" monoclonal autoantibodies should facilitate the identification of specific epitopes inducing this response...
  72. pmc A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 76:2660-70. 2008
    ..b>Rabbits were immunized with FVO strain PfAMA1 or with the DiCo proteins either individually or as a mixture...
  73. pmc Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research Bangladesh, Centre for Health and Population Research, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:9178-83. 2006
    ..In this study, Shigella-infected dysenteric rabbits were treated with butyrate (0...
  74. pmc Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 78:2248-56. 2010
    ..To better understand if conserved regions in VAR2CSA can be targeted by antibodies, we immunized rabbits with VAR2CSA-DBL1 and -DBL5 recombinant proteins produced in Pichia pastoris and developed a panel of seven ..
  75. ncbi Refractive lenticule re-implantation after myopic ReLEx: a feasibility study of stromal restoration after refractive surgery in a rabbit model
    Romesh I Angunawela
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 53:4975-85. 2012
    ..To investigate the potential of refractive lenticule (RL) storage and re-implantation in vivo as a method for reversing RL extraction (ReLEx) and restoring corneal stromal volume...
  76. ncbi Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC
    Acta Biomater 8:1068-79. 2012
    ..It is concluded that the cultured RCKs on surfaces coated with HA of different MWs can sense ECM cues, and the multicellular spheroids may potentially be used for corneal stromal tissue engineering applications...
  77. ncbi Regulation of aquaporin water permeability in the lens
    Kulandaiappan Varadaraj
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Invest Ophthalmol Vis Sci 46:1393-402. 2005
    ..To examine Ca(2+)- and pH-mediated regulation of water permeability of endogenously expressed aquaporin (AQP)0 in lens fiber cells and AQP1 in lens epithelial cells...
  78. ncbi Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
    L M Hondeghem
    Department of Pharmacology, Leuven, Belgium
    Circulation 103:2004-13. 2001
    ..Prolongation of action potential duration (APD) is considered a major antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade de pointes)...
  79. pmc Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e16414. 2011
    ..PfEMP1 is a possible target for a vaccine to induce antibodies to inhibit rosetting and prevent severe malaria...
  80. ncbi Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart
    G Andre Ng
    Cardiology Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    Cardiovasc Res 73:750-60. 2007
    ..We examined the effects of direct sympathetic (SS) and vagus (VS) nerve stimulation on electrical restitution, alternans and VF threshold (VFT) in a novel isolated rabbit heart preparation with intact dual autonomic innervation...
  81. ncbi Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits
    Stephen J Nicholls
    Heart Research Institute, Sydney, Australia
    Circulation 111:1543-50. 2005
    ..HDLs have antiinflammatory and antioxidant properties in vitro. This study investigates these properties in vivo...
  82. ncbi A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomaterials 33:2372-87. 2012
    ..e., miosis and IOP lowering effect and preservation of corneal endothelial cell density)...
  83. pmc A robust rabbit model of human atherosclerosis and atherothrombosis
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 50:787-97. 2009
    ..Our findings reveal novel insights into plaque vulnerability and could guide the design of noninvasive imaging approaches for detecting and treating high-risk plaques...
  84. pmc Evaluation of the levofloxacin release characters from a rabbit foldable capsular vitreous body
    Zhaoxin Jiang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:1-10. 2012
    ..In vivo, the FCVB with levofloxacin was implanted into the right eyes of five rabbits. After implantation, the aqueous humor was aspirated on days 1, 7, 14, 28, and 56...
  85. ncbi Treatment with methotrexate inhibits atherogenesis in cholesterol-fed rabbits
    Adriana Bulgarelli
    Lipid Metabolism Laboratory, Heart Institute of the Medical School Hospital InCor, A C Camargo Hospital, Sao Paulo, Sao Paulo, Brazil
    J Cardiovasc Pharmacol 59:308-14. 2012
    ..study was to test whether MTX could promote anti-inflammatory effects and reduce the atherosclerotic lesions in rabbits with atherosclerosis induced by cholesterol feeding...
  86. ncbi The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells
    K Yata
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Leukemia 18:1891-7. 2004
    ..This system can now be widely used to study the biology of myeloma and its manifestations and to develop novel therapeutic approaches for this disease...
  87. pmc Active Immunization with Pneumolysin versus 23-Valent Polysaccharide Vaccine for Streptococcus pneumoniae Keratitis
    Erin W Norcross
    Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Invest Ophthalmol Vis Sci 52:9232-43. 2011
    ..The purpose of this study was to determine whether active immunization against pneumolysin (PLY), or polysaccharide capsule, protects against the corneal damage associated with Streptococcus pneumoniae keratitis...
  88. ncbi Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region
    Kazunari Kondo
    Center for Pathogen Genomics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 358:266-72. 2007
    ..containing the cross-neutralization epitopes of HPV16 L2, we characterized antisera obtained by immunizing two rabbits with each of the ten synthetic peptides of 14 to 20 amino acids (aa) long, which represents a part of the HPV16 ..
  89. pmc Critical roles for stx2, eae, and tir in enterohemorrhagic Escherichia coli-induced diarrhea and intestinal inflammation in infant rabbits
    Jennifer M Ritchie
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, and Howard Hughes Medical Institute, Boston, Massachusetts 02111, USA
    Infect Immun 71:7129-39. 2003
    ..coli O157:H7 clinical isolate into infant rabbits led to severe diarrhea and intestinal inflammation but no signs of HUS...
  90. ncbi A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120
    Simon Beddows
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Room W 805, New York, NY 10021, USA
    Virology 360:329-40. 2007
    ..We have directly compared the immunogenicity in rabbits of two forms of soluble trimeric Env and monomeric gp120 based on the sequence of HIV-1(JR-FL)...
  91. pmc Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites
    Sash Lopaticki
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 79:1107-17. 2011
    ..falciparum. We immunized rabbits with combinations of PfRh and EBL proteins to test the ability of antibodies to block merozoite invasion in ..
  92. pmc Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae
    Jun Zheng
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:21128-33. 2010
    ..VgrG-1 into macrophage cells, and T6SS activation leads to fecal diarrhea and intestinal inflammation in infant rabbits. Using an infant mouse infection model, we show that deletion of tsrA results in a 9...
  93. pmc Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1
    William M Gwinn
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Vaccine 28:6901-14. 2010
    ..for the induction of serum antibody responses when nasally administered with protein antigens in mice and rabbits. In mice, intranasal (i.n...
  94. ncbi Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
    Joseph T Bruder
    GenVec, Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20878, USA
    Vaccine 28:3201-10. 2010
    ..Adenovector delivery induced unprecedented levels of biologically active antibodies in rabbits as indicated by the parasite growth inhibition assay...
  95. pmc Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits
    Armando Geraldes
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, Vairao, Portugal
    Mol Biol Evol 27:2437-40. 2010
    ..This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome...
  96. ncbi Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140
    Suganya Selvarajah
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    AIDS Res Hum Retroviruses 24:301-14. 2008
    ..The gp140-CART mCHO(V) mutant and gp140-CART wild-type soluble trimer protein were used to immunize rabbits. The gp140-CART mCHO(V) immune sera had reduced antibody response to the variable loops compared to gp140-CART ..
  97. ncbi TRIC channels are essential for Ca2+ handling in intracellular stores
    Masayuki Yazawa
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nature 448:78-82. 2007
    ..Therefore, TRIC channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores...
  98. ncbi Immunohistochemical distribution of 11beta-hydroxysteroid dehydrogenase in human eye
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Mol Cell Endocrinol 173:121-5. 2001
    ..The widespread expression of GR suggests that glucocorticoids may play an important role in the function and homeostasis of the human eye...
  99. pmc Polyclonal antibody against the DPV UL46M protein can be a diagnostic candidate
    Liting Lu
    Avian Diseases Research Center, College of Veterinary Medicine of Sichuan Agricultural University, YA, AN, Sichuan, China
    Virol J 7:83. 2010
    ..a Ni-NTA spin column and used to generate the polyclonal antibody against UL46 and UL46M in New Zealand white rabbits. The titer was then tested using enzyme-linked immunosorbent assay (ELISA) and agar diffusion reaction, and the ..
  100. ncbi Mapping of the complement C9 binding domain in paramyosin of the blood fluke Schistosoma mansoni
    Jiusheng Deng
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Parasitol 37:67-75. 2007
    ..Taken together, this study has mapped the complement regulatory domain in Pmy, capable of binding to C8 and C9 and preventing polyC9 formation, to its C-terminal region...
  101. ncbi Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes
    X Li
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:15695-702. 1996

Research Grants73

    David Allen; Fiscal Year: 2009
    ..four most commonly required product safety tests and can therefore involve large numbers of animals, and because rabbits used in tests to identify ocular hazards can experience significant pain and distress when eye injuries occur...
  2. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..PRL) was discovered in 1928 as a pituitary factor able to stimulate mammary gland development and lactation in rabbits, as well as the production of crop milk in pigeons...
  3. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..and triggered activity (TA), and has been suggested as a potential proarrhythmic factor in rats, guinea pigs, and rabbits. Our recent studies have revealed that H2O2 induces EAD, DAD and TA via activation of the Ca/Calmodulin-dependent ..
  4. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..The vaccine was purified, characterized, and injected into mice and rabbits to demonstrate its immunogenicity...
  5. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..A pre-clinical safety and tolerability study will be conducted in rabbits as a requirement for progression to human trials...
    Vijay Sharma; Fiscal Year: 2013
    ..and flow-extraction correlation under stress/rest conditions in rats, followed by assessment of leads in rabbits, using microPET imaging...
    Linda M Graham; Fiscal Year: 2013
    ..in areas of arterial injury in mice and onto prosthetic grafts implanted in normal and hypercholesterolemic rabbits will be assessed...
  8. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..Previous animal models have infected rabbits, rats and mice with different viruses...
  9. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..in rats, and assess the irritation and safety of NAL6336 ODF by buccal oral mucosal irritation studies in rabbits and hamsters...
  10. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..In Specific Aim 3, the effect of neurotrophins on epithelial repair following chlorine exposure in rabbits will be investigated...
  11. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..Validate and optimize the integrated system by imaging phantoms and the eyes of normal rats and rabbits. Aim 4...
  12. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..FHC-linked mutations, we will also use Ca2+ sensitization by EMD to model effects of sarcomeric mutations in rabbits to test the hypothesis in a model with more human-like cardiac electrophysiology...
  13. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..a suite for immuno-compromised animals, specialized linear sequenced-procedure rooms and holding space for rabbits outside the barrier accessible to researchers through Gillespie...
  14. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..Cu may reduce A[unreadable] elimination from brain in rabbits, dosed with tracer levels of Cu...
  15. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..clinical trials if a live HSV-2 vaccine strain proves to be safe and effective in protecting mice, guinea pigs, rabbits, and hamsters against genital herpes...
  16. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..to induce partial immunity (>60% reduction in parasite burden and significant reduction of liver damage) in rabbits and mice challenged with F. hepatica metacercariae. FhSAP2 is an 11.5kDa polypeptide belonging to the F...
  17. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..When infected with Leishmania, rabbits and mice develop antibodies to a type of molecule with fat and sugars called glycoinositol phospholipids (GIPLs), ..
  18. Bioengineering of Novel Synthetic Lipid-Peptide Lung Surfactants
    Robert H Notter; Fiscal Year: 2013
    ..infants with NRDS;(ii) mice with ALI/ARDS in vivo from intratracheal instillation of lipopolysaccharide (LPS);(3) rabbits with ALI/ARDS in vivo from severe hyperoxic-exposure;and (4) ventilated rabbits with surfactant-deficiency and ..
  19. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..In our model of IVH in premature rabbits, there is an arrest of oligodendrocyte (OL) maturation at a pre-myelinating stage...
    Tariq M Haqqi; Fiscal Year: 2010
    ..that "oral consumption of PFE inhibits cartilage degradation and suppresses the progression of knee OA in rabbits induced by anterior cruciate ligament transection (ACLT)"...
  21. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ..RCT after rhLCAT injection, 2) to determine if rhLCAT will induce rapid changes in atherosclerotic lesions in rabbits, 3) to conduct a toxicology study in non-human primates to obtain the data for an Investigational New Drug ..
  22. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..High-titer neutralizing antibodies were elicited in rabbits after a single boost...
  23. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..In Aim 3 we explore the efficacy of these probes in fresh and aged thrombus models in rats and rabbits using PET-CT and PET-MRI...
  24. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..Aim Bii) Study the development of AF (by ECG telemetry) in young (6 mo) and old (>5yrs) rabbits immunized to produce target-specific AAB1AR and/or AAM2R without and with thyroid hormone...
  25. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..antigen stability and delivery efficiency and (ii) to compare OC and intramuscular (IM) routes of immunization in rabbits using well characterized HIV antigens with focus on anti-HIV antibodies in the saliva, and at other distal mucosa...
  26. Proteome-wide screen for M. tuberculosis antigens
    Robert N Husson; Fiscal Year: 2010
    ..these arrays will be probed with serum obtained at carefully defined stages of TB infection from Mtb-infected rabbits, an excellent model of human TB, including latent TB and reactivation after immune suppression...
  27. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..virus (AAV)-decorin gene therapy efficiently inhibits corneal fibrosis and neovascularization in vivo in rabbits. It did not show any short-term toxicity...
  28. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    A herpesvirus, referred to as LHV-4, was found to be associated with a disease affecting over half of the 55 rabbits on a farm near Anchorage, Alaska...
    Tariq M Haqqi; Fiscal Year: 2011
    ..of PFE will inhibit the cartilage degradation and suppress the progression of experimentally induced OA in rabbits (Specific Aim 5)...
  30. Intralipid: A novel frontline countermeasure for brodifacoum poisoning
    Douglas L Feinstein; Fiscal Year: 2013
    ..poisoning;since testing in humans is not feasible, in year 4 of this project we will carry out similar studies in rabbits to match the FDA requirements under the animal rule for a new drug...
  31. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..In aim 4, topical cross-linking of live rabbits will be undertaken...
  32. Calcium Signaling, Metabolism, and EC Coupling in Heart
    Joshua I Goldhaber; Fiscal Year: 2013
    ..The specific aims are to study ventricular cells from rabbits and mice (including cardiac-specific sodium-calcium exchanger knock-out mice) to: 1) investigate calcium ..
  33. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ..In vivo studies in bisphosphonate-treated mice and rabbits demonstrate decreased long bone growth, accompanied by expansion of the hypertrophic chondrocyte layer and ..
  34. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2013
    Project Summary Myxoma virus (MV) infects only rabbits in vivo, but also has a natural capacity to infect a wide variety of human cancer cells in vitro and in vivo...
    Sufan Chien; Fiscal Year: 2013
    ..The technique has been tested in full-thickness excisional skin wounds in mice and rabbits. VitaSolTM healed wounds faster than all control dressings, which included Mg-ATP alone, lipid vesicles alone, a ..
  36. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    WARNER KING HUH; Fiscal Year: 2012
    ..Furthermore, vaccination of rabbits with HPV16 L2 11-200 protects against both cutaneous infection with cottontail rabbit papillomavirus (CRPV) and ..
  37. 5-HT Stimulation of Mitochondrial Biogenesis and Acute Kidney Injury
    Rick G Schnellmann; Fiscal Year: 2013
    ..mRNA isolated from RPTC confirmed the expression of 5-HT2 receptor subtypes 5-HT2A, 5-HT2B and 5-HT2C in humans, rabbits, rats and mice...
  38. Occupational exposure to manganese and noise potentiate hearing loss
    Richard J Salvi; Fiscal Year: 2013
    ..This is consistent with another recent report, demonstrating that welding fumes induce hearing impairment in rabbits and that the hearing deficits are exacerbated by exposure to noise...
  39. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..The co-drug elicits no acute toxicology in Draize testing in rabbits. The co-drug is cleaved by cellular esterases to release a pro-reductant, that when converted to active reducing ..
  40. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..Pathogen-free New Zealand White rabbits will be studied...
  41. Development of Superactive Analogs of FSH for Human Infertility
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..of all FDA-required toxicology studies including two-generation reproductive toxicology assessment in rats and rabbits;and submission of IND to initiate clinical trials...
  42. cGMP manufacturing of PBI-220, a broad spectrum immunoadhesin therapeutic against
    LLOYD M YU; Fiscal Year: 2013
    ..We will also advance the study of anthrax and PBI-220 in Dutch Belted White rabbits and continue safety evaluation, stability testing and product optimization as we demonstrate that the recombinant ..
  43. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..the toxicity of the new Cu and RSe-based coatings using standard ISO protocols with small animals (mice and rabbits);and 5) testing the longer-term in vivo thromboresistance of the most promising new NO generating coatings in ..
  44. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    ..cell cultures of neonatal spermatogonia, as well as in vivo using the vitamin-A deficient mouse model and normal rabbits. In specific aim #2, we will endeavor to demonstrate that WIN 18,446 specifically inhibits ALDH1a2 using cell ..
  45. Sex Hormones and Cardiac Arrhythmia in Transgenic LQT2 Rabbits
    Gideon Koren; Fiscal Year: 2012
    ..This multi-pronged approach includes the investigation of hormone-treated prepubertal, ovariectomized LQT2 rabbits to explore new mechanistic paradigms that underlie the effects of sex hormones on cardiac arrhythmias using in ..
  46. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
    ..Despite this, work in baboons, rabbits, and mice, supported by human population data, strongly indicate that fXI makes important contributions to ..
  47. Commercialization of iSONEP, a Humanized Monoclonal Antibody Against the Bioactiv
    ROGER ALLEN SABBADINI; Fiscal Year: 2010
    ..mAbs have demonstrated efficacy in several animal models of wet AMD;moreover, iSONEP is well tolerated by mice, rabbits, non-human primates, and humans alike...
  48. Epitope-specific vaccines targeting the alpha toxin of Staphylococcus aureus
    KEMP BAILEY CEASE; Fiscal Year: 2013
    ..evaluation of vaccine safety in the murine model, MAP vaccines will be validated for immunogenicity in outbred rabbits using human use adjuvants, and the rabbit antisera will be evaluated for protective efficacy using passive ..
  49. Cytokine and neurotransmitter interactions in sleep regulation
    Mark R Opp; Fiscal Year: 2012
    ..Indeed, one retrospective study demonstrates that specific sleep patterns of rabbits are associated with survival from infection...
  50. Hypertrophy Regression with N-Acetylcysteine in Hypertrophic Cardiomyopathy
    Ali J Marian; Fiscal Year: 2013
    ..In three independent studies in two different transgenic models of HCM (rabbits and mouse), treatment with NAC completely reversed cardiac hypertrophy and fibrosis and improved indices of ..
  51. Monitoring Red Cell Metabolism using a Lab on a Chip
    Dana M Spence; Fiscal Year: 2010
    ..an amperometric detection scheme on a microfluidic device to determine the ratio of GSH:GSSG in the RBCs of rabbits, 2) To develop an amperometric assay on a microfluidic device to determine the levels of NADPH in the RBCs of ..
  52. Metabolic Oscillations in Heart
    JAMES N contact WEISS; Fiscal Year: 2010
    ..simulations and nonlinear dynamics with experimental patch-clamp and imaging studies in isolated myocytes from rabbits, wild-type and genetically-altered mice and neonatal rat ventricular myocyte monolayers subjected to coverslip ..
  53. Pre-Clinical Development of a Fetal Micropacemaker
    Ramen Chmait; Fiscal Year: 2013
    ..A functional prototype of the device has been built, and animal testing using adult rabbits has provided compelling data regarding key aspects of the electronic and mechanical design strategies...
  54. Develop an Oral HIV Vaccine Using Papilloma Virus-Like Particles as a Vector
    Liang Qiao; Fiscal Year: 2012
    ..able to infect oral lymphoid tissues and induce mucosal and systemic HIV-1-specific immune responses in mice and rabbits. We will also determine if these vaccines can protect mice with human CD4 and CCR5 transgenes against HIV-1 ..
  55. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ..g., rabbits, monkeys) with a high sensitivity brain scanner that enables not only 18FDG and 11C-PIB imaging but dynamic neuro-..
  56. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..Toward the development of an IND application, we will also investigate the microneedle safety in rabbits which have higher skin sensitivity than rats. The Specific Aims are as follows: 1...
  57. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2013
    ..will determine (a) if a genotype 1 human HEV (infecting humans only) will acquire the ability to infect pigs and rabbits if its HVR is replaced with that o a zoonotic genotype 3 HEV, (b) if the genotype 1 human HEV with an inserted ..
  58. Installation of Energy-Efficient Cage Washers for Childrens Hospital Vivarium
    Philip R Johnson; Fiscal Year: 2012
    ..The vivarium houses both large animal species (dogs, pigs, sheep, and rabbits) and CHOP's rodent quarantine facility...
  59. Cholesterol induces oxidative stress and triggers iron and A? accumulation
    Othman Ghribi; Fiscal Year: 2012
    ..We will be using a long-term cholesterol-enriched diet in the rabbits a model system that we have found to demonstrate iron deposition, beta-amyloid (Abeta) accumulation, and ..
    Neil Schneiderman; Fiscal Year: 2013
    ..center serving low income Blacks and Hispanics/Latinos and Project 3 examines Watanabe heritable hyperlipidemic rabbits and knockout mice...
  61. Pre-clinical Development of a Broad Spectrum Antiviral Compound to Treat Human Pa
    Christopher Fisher; Fiscal Year: 2012
    ..for Pilot PK/toxicology studies and demonstration of in vivo cervical uptake following vaginal delivery in rabbits;systemic exposure will also be followed during these tests;5) Scaling up chemical synthesis and formulation of ..
  62. Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSV
    George E Wright; Fiscal Year: 2012
    ..determine the oral bioavailability of mCF3PG in rabbits and guinea pigs after oral treatment with Sacrovir;and 4) test, through collaborators, the efficacy of oral ..
    Judith James; Fiscal Year: 2000
    Description The applicant, and her mentor, John Harley, M.D., Ph.D., have recently demonstrated that normal rabbits immunized with specific short peptides derived from the Sm autoantigen develop high levels of both anti-Sm and anti-nRNP ..
  64. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..The effect of estrogen-replacement in post- menopausal women on arrhythmia vulnerability remains unknown. Female rabbits have longer APDs and QT intervals than males and a greater vulnerability to LQT-related arrhythmias...
    K Y Pau; Fiscal Year: 2000
    ..adapted from the applicants abstract) Coitus induces a concatenation of neurohumoral events in New Zealand White rabbits that includes increased secretion of norepinephrine (NE), gonadotropin-releasing hormone (GnRH), luteinizing ..
  66. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..coli (EHEC) infection, in rabbits and dogs, to develop therapeutic regimens to prevent and treat EHEC disease...
    JOHN COLERIDGE; Fiscal Year: 1992
    It is proposed to continue studies in anesthetized dogs, cats and rabbits of the sensory characteristics of vagal and sympathetic afferent nerve fibers arising from the lower respiratory tract, and of the protective and homeostatic ..
  68. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..harboring Mst1 with or without tissue specific promoters in preventing in-stent restenosis in iliac arteries of rabbits fed with a high cholesterol diet...
    CHARLES SPARKS; Fiscal Year: 1990
    Monosaccharides and disaccharides are known to result in hyperlipoproteinemia in rabbit nutritional studies. In rabbits fed semi-purified diets, sucrose as a carbohydrate source results in hyperlipoproteinemia in excess of that of ..
    RONALD SCHUELER; Fiscal Year: 1993
    Maintain and provide for the care and breeding of genetically defined rabbits (approximately 600 past the age of weaning). House rabbits in cage meeting Government requirements and provided by the Government...
    Michael Harper; Fiscal Year: 1991
    ..The specific aims are to: 1) characterize the binding parameters of these PAF specific sites in rabbits, by comparing binding affinities and capacities of oviductal and uterine tissues in pregnant and pseudopregnant ..
    Edgar Boedeker; Fiscal Year: 1999
    ..or ameliorate damage in target organs (gut, CNS and kidney) Escherichia coli strain RDEC-H19A infection of rabbits will serve as the animal model of EHEC disease for these studies...
    Katherine Knight; Fiscal Year: 2000
    ..IgA heavy chains will be determined by developing IgA- secreting rabbit X rabbit hybridomas from heterozygous rabbits and cloning their VDJ and C/a genes...