Genomes and Genes
Summary: A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications325 found, 100 shown here
- Patterns of East Asian pig domestication, migration, and turnover revealed by modern and ancient DNAGreger Larson
State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
Proc Natl Acad Sci U S A 107:7686-91. 2010..151 previously uncharacterized specimens) and 18 ancient (representing six East Asian archeological sites) pig (Sus scrofa) DNA sequences sampled across East Asia, we provide evidence for the long-term genetic continuity between modern ..
- Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCRAnn Britt Nygard
University of Copenhagen, Faculty of Life Sciences, Department of Basic Animal and Veterinary Sciences, Division of Genetics and Bioinformatics, Groennegaardsvej 3, 1870 Frederiksberg C, Denmark
BMC Mol Biol 8:67. 2007..Selection of high quality reference genes is of crucial importance for the interpretation of data generated by real-time qPCR...
- Worldwide phylogeography of wild boar reveals multiple centers of pig domesticationGreger Larson
Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
Science 307:1618-21. 2005..In contrast, new genetic data reveal multiple centers of domestication across Eurasia and that European, rather than Near Eastern, wild boar are the principal source of modern European domestic pigs...
- A snapshot of CNVs in the pig genomeJoão Fadista
Group of Molecular Genetics and Systems Biology, Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark
PLoS ONE 3:e3916. 2008..This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits...
- Evidence of the role of European wild boar as a reservoir of Mycobacterium tuberculosis complexVictoria Naranjo
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
Vet Microbiol 127:1-9. 2008..The European wild boar (Sus scrofa) is frequently considered a spillover or dead end host rather than a true reservoir, and scientific evidence is ..
- Deciphering the porcine intestinal microRNA transcriptomeSoroush Sharbati
Freie Universitat Berlin, Institute of Veterinary Biochemistry, Oertzenweg 19b, 14163 Berlin, Germany
BMC Genomics 11:275. 2010..g. intestinal development or disease. Recent studies indicate that miRNAs are key regulators of intestinal development and their aberrant expression leads to intestinal malignancy...
- Ancient DNA, pig domestication, and the spread of the Neolithic into EuropeGreger Larson
Department of Zoology, Henry Wellcome Ancient Biomolecules Centre, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 104:15276-81. 2007..Domestic pigs formed a key component of the Neolithic Revolution, and this detailed genetic record of their origins reveals a complex set of interactions and processes during the spread of early farmers into Europe...
- MicroRNA expression profiling of the porcine developing brainAgnieszka Podolska
Department of Basic Animal and Veterinary Sciences, Section of Genetics and Bioinformatics, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 6:e14494. 2011..Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain...
- Contrasting mode of evolution at a coat color locus in wild and domestic pigsMeiying Fang
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
PLoS Genet 5:e1000341. 2009..diversity at the porcine melanocortin receptor 1 (MC1R) locus, we provide evidence that wild and domestic pig (Sus scrofa) haplotypes from China and Europe are the result of strikingly different selection pressures, and that coat ..
- The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulenceLei Zhou
Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People s Republic of China
J Virol 83:5156-67. 2009..RvHB1-ND30 exhibited low virulence for piglets, like RvHB-1/3.9 and the parental virus HB-1/3.9. Therefore, we conclude that the 30-amino-acid deletion is not related to the virulence of the highly pathogenic PRRSV emerging in China...
- Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatnessXiao Zhao
State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
PLoS ONE 6:e19774. 2011..The raw data have been submitted to Gene Expression Omnibus (GEO) under series GSE25406...
- Mitochondrial lineages reveal intense gene flow between Iberian wild boars and South Iberian pig breedsB Van Asch
Instituto de Patologia e Imunologia da Universidade do Porto IPATIMUP, Rua Dr Roberto Frias s n, Porto, Portugal
Anim Genet 43:35-41. 2012The phylogeography of wild boars (WB) and domestic pigs (Sus scrofa) has contributed important insights into where and when domestication occurred...
- MicroRNA identity and abundance in porcine skeletal muscles determined by deep sequencingM Nielsen
Department of Genetics and Biotechnology, Aarhus University, DK Tjele, Denmark
Anim Genet 41:159-68. 2010....
- Genome-wide single nucleotide polymorphism analysis reveals recent genetic introgression from domestic pigs into Northwest European wild boar populationsD J Goedbloed
Resource Ecology Group, Wageningen UR, Wageningen, The Netherlands
Mol Ecol 22:856-66. 2013....
- A genome-wide association scan in pig identifies novel regions associated with feed efficiency traitGoutam Sahana
Department of Molecular Biology and Genetics, Aarhus University, Blichers alle 20, Postboks 50, DK 8830 Tjele, Denmark
J Anim Sci 91:1041-50. 2013..The study provides a list of SNP associated with FCR and also offers valuable information on the genetic architecture and candidate genes for this trait...
- Animal QTLdb: beyond a repository. A public platform for QTL comparisons and integration with diverse types of structural genomic informationZhi Liang Hu
Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011 3150, USA
Mamm Genome 18:1-4. 2007..animalgenome.org)...
- Quantitative trait loci analysis for growth and carcass traits in a Meishan x Duroc F2 resource populationS Sato
National Livestock Breeding Center, Nishigo, Fukushima 961 8511, Japan
J Anim Sci 81:2938-49. 2003..quantitative trait loci (<1% genomewise error rate) affecting weight at 30 d and average daily gain on Sus scrofa chromosome (SSC) 6, carcass yield on SSC 7, backfat thickness on SSC 7 and SSC X, vertebra number on SSC 1 and ..
- Linkage disequilibrium decay and haplotype block structure in the pigAndreia J Amaral
Animal Breeding and Genomics Centre, Wageningen UR, 6700AH, Wageningen, The Netherlands
Genetics 179:569-79. 2008..Second, modern breeding programs increased the extent of LD in Europe and caused differences of LD between genomic regions. Large White, Landrace, and Duroc showed evidence of past introgression from Chinese breeds...
- LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigsZhonglin Tang
Department of Gene and Cell Engineering, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China
Genome Biol 8:R115. 2007..Here, we describe a genome-wide analysis of differences in prenatal skeletal muscle between Tongcheng (a typical indigenous Chinese breed) and Landrace (a leaner Western breed) pigs...
- Analysis of muscle and ovary transcriptome of Sus scrofa: assembly, annotation and marker discoveryQinghua Nie
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, GuangDong 510642, People s Republic of China
DNA Res 18:343-51. 2011Pig (Sus scrofa) is an important organism for both agricultural and medical purpose. This study aims to investigate the S. scrofa transcriptome by the use of Roche 454 pyrosequencing...
- Comparative analysis of monocyte subsets in the pigLynsey Fairbairn
The Roslin Institute and The Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom
J Immunol 190:6389-96. 2013..The results are discussed in terms of the relevance of the pig as a model for understanding human monocyte function...
- Epidemiology, diagnosis, treatment, and control of trichinellosisBruno Gottstein
Faculty of Medicine, Institute of Parasitology, University of Bern, Bern, Switzerland
Clin Microbiol Rev 22:127-45, Table of Contents. 2009..The evidence that the disease can be monitored and to some extent controlled with a rigorous reporting and testing system in place should be motivation to expand appropriate programs worldwide...
- Synergistic effects of glutathione and β-mercaptoethanol treatment during in vitro maturation of porcine oocytes on early embryonic development in a culture system supplemented with L-cysteineChangyong Choe
Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA, Namwon, Korea
J Reprod Dev 56:575-82. 2010..05). These results suggest that a combination of 1 mM GSH or 25 µM β-ME with 1 mM L-cysteine could be used for production of high quality porcine blastocysts in IVC systems...
- Ancient vs. recent processes as factors shaping the genetic variation of the European wild boar: are the effects of the last glaciation still detectable?M Scandura
Dipartimento di Zoologia e Genetica Evoluzionistica, Universita di Sassari, Via Muroni 25, 07100 Sassari, Italy
Mol Ecol 17:1745-62. 2008..In this context controlling some populations by hunting is not expected to affect significantly genetic variation in this species...
- Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responsesEllen Kanitz
Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
Brain Behav Immun 18:35-45. 2004..Using the pig as a suitable animal model, the finding of this study may also have some implications for the etiology of anxiety and depression in humans...
- Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease modelAna M Gonzalez
Department of Veterinary Preventive Medicine, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
Immunology 131:242-56. 2010..Stimulation of the anti-inflammatory effects of pDCs after the high dose, without increasing their pro-inflammatory impacts, may be critical to reduce further immunopathology during HRV infection...
- The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pigBin Fan
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
Anim Biotechnol 20:58-70. 2009....
- Identification and characterization of microRNAs from porcine skeletal muscleS S Xie
Huazhong Agricultural University, Wuhan, China
Anim Genet 41:179-90. 2010..Our results add to existing data on porcine miRNAs and are useful for investigating the biological functions of miRNAs in porcine skeletal muscle development...
- Wild boars as sources for infectious diseases in livestock and humansX J Meng
Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, CRC Integrated Life Sciences Building, Blacksburg, VA 24061 0913, USA
Philos Trans R Soc Lond B Biol Sci 364:2697-707. 2009Wild boars (Sus scrofa) are indigenous in many countries in the world. These free-living swine are known reservoirs for a number of viruses, bacteria and parasites that are transmissible to domestic animals and humans...
- The contribution of social effects to heritable variation in finishing traits of domestic pigs (Sus scrofa)R Bergsma
Institute for Pig Genetics, Beuningen, The Netherlands
Genetics 178:1559-70. 2008..Our results suggest that genetic improvement in agriculture can be substantially advanced by redirecting breeding schemes, so as to capture heritable variance due to social effects...
- A linkage map of the porcine genome from a large-scale White Duroc x Erhualian resource population and evaluation of factors affecting recombination ratesY Guo
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
Anim Genet 40:47-52. 2009..However, recombination rates on paternal chromosomes were affected by the mating season of the F(1) animals. This could represent an effect of environmental temperature on spermatogenesis...
- Risk factors associated with the prevalence of tuberculosis-like lesions in fenced wild boar and red deer in south central SpainJoaquin Vicente
Instituts de Investigación en Recursos cinegéticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13080 Ciudad Real, Spain
Vet Res 38:451-64. 2007..factors which investigated associations between the pattern of tuberculosis-like lesions (TBL) in wild boar (Sus scrofa) and red deer (Cervus elaphus) across 19 hunting estates from SCS and an extensive set of variables related to ..
- Unexpected sequence types in livestock associated methicillin-resistant Staphylococcus aureus (MRSA): MRSA ST9 and a single locus variant of ST9 in pig farming in ChinaJaap A Wagenaar
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
Vet Microbiol 139:405-9. 2009..The study confirms that livestock may act as a reservoir for MRSA...
- Progress in the control of bovine tuberculosis in Spanish wildlifeChristian Gortazar
IREC CSIC UCLM JCCM, Ronda de Toledo s n, Ciudad Real 13071, Spain
Vet Microbiol 151:170-8. 2011..Finally, preliminary vaccination and challenge experiments suggested that a single oral BCG vaccination may protect wild boar from infection by a virulent M. bovis field strain...
- A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource populationG Liu
Animal Breeding and Husbandry Group, Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
Anim Genet 38:241-52. 2007..Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression...
- Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte functionE Wattrang
Department of Molecular Biosciences, Section of Veterinary Immunology and Virology, Swedish University of Agricultural Sciences, Box 588, SE 751 23 Uppsala, Sweden
Anim Genet 36:337-45. 2005..05). The results confirm the involvement of earlier identified regions of SSC1 and SSC8 on porcine immune parameters and some candidate genes were suggested...
- Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infectionRuth C Galindo
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, Ciudad Real 13005, Spain
Parasit Vectors 5:181. 2012..The objective of this research was to characterize gene expression in pigs (Sus scrofa) naturally and experimentally infected with A...
- Integrating comparative expression profiling data and association of SNPs with Salmonella shedding for improved food safety and porcine disease resistanceJ J Uthe
Department of Animal Science, Iowa State University, Ames, IA 50014, USA
Anim Genet 42:521-34. 2011..These associations provide new information about the mechanisms of porcine host response to Salmonella and may be useful in improving genetic resistance to this bacterium...
- Multi-locus analysis reveals a different pattern of genetic diversity for mitochondrial and nuclear DNA between wild and domestic pigs in East AsiaYin Qiu Ji
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
PLoS ONE 6:e26416. 2011....
- Brucellosis in the United States: role and significance of wildlife reservoirsS C Olsen
Bacterial Disease of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
Vaccine 28:F73-6. 2010..Although some tools are currently available for use in the wildlife reservoirs, development of new vaccines, diagnostics, and management procedures will most likely be needed for effective control of brucellosis...
- Surveillance of bovine tuberculosis and risk estimation of a future reservoir formation in wildlife in Switzerland and LiechtensteinJanne Marie Schöning
Centre for Fish and Wildlife Health FIWI, Vetsuisse Faculty, University of Bern, Bern, Switzerland
PLoS ONE 8:e54253. 2013..data for Swiss and Liechtenstein wildlife are not available so far, although two native species, wild boar (Sus scrofa) and red deer (Cervus elaphus elaphus), act as bTB reservoirs elsewhere in continental Europe...
- Most of the benefits from genomic selection can be realized by genotyping a small proportion of available selection candidatesM Henryon
Danish Agriculture and Food Council, Pig Research Centre, Axeltorv 3, 1609 Copenhagen V, Denmark
J Anim Sci 90:4681-9. 2012..Our findings should benefit breeders because they suggest that large investments in genotyping are not required to reap most of the benefits from genomic selection...
- Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: results from a White Duroc x Erhualian intercross F2 populationT Guo
Key Laboratory for Animal Biotechnology of Jiangxi Province, Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
Anim Genet 40:185-91. 2009..Chinese Erhualian alleles were associated with increased ratios of MUFA to saturated fatty acid at most of the QTL detected, showing beneficial effect in terms of human health...
- Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6qJennifer G Sambrook
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, England, UK
Immunogenetics 58:481-6. 2006..identified by comparative genomics the first and possibly only KIR gene, named KIR2DL1, in the domesticated pig (Sus scrofa) allowing further evolutionary comparisons to be made...
- Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAsPaul Dremsek
Friedrich Loeffler Institut, Federal Research Institute for Animal Health, OIE Collaborating Centre for Zoonoses in Europe, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493, Greifswald Insel Riems, Germany
Med Microbiol Immunol 201:189-200. 2012..The epidemiological role of ratHEV in human disease should be assessed in a large-scale study of risk and non-risk groups...
- Identification and comparison of microRNAs from skeletal muscle and adipose tissues from two porcine breedsHong yi Li
Guangdong Provincial Key Laboratory of Agro animal Genomics and Molecular Breeding, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, China
Anim Genet 43:704-13. 2012..The great diversity of miRNA composition and expression levels both between breeds and between tissues suggests that a complex regulatory network exists in porcine subcutaneous fat development...
- Why working with porcine circulating serum amyloid A is a pig of a jobL Soler
Department of Animal Medicine and Surgery, University of Murcia, 30100 Espinardo, Murcia, Spain
J Theor Biol 317:119-25. 2013..It is concluded that pig systemic SAA is unique compared to other species, which raises questions about the proposed importance of acute phase SAA in HDL metabolism during inflammation in this species...
- Porcine kobuvirus in wild boars (Sus scrofa)Gabor Reuter
Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, Szabadság út 7, 7623, Pecs, Hungary
Arch Virol 158:281-2. 2013Fecal samples (N = 10) from 6- to 8-week-old wild boar piglets (Sus scrofa), collected from an animal park in Hungary in April 2011, were analyzed using viral metagenomics and complete genome sequencing...
- A chronologic review of mature oocyte vitrification research in cattle, pigs, and sheepS F Mullen
The World Egg Bank, Phoenix, Arizona, USA
Theriogenology 78:1709-19. 2012..Messenger RNA levels are reportedly altered in sheep oocytes as a result of vitrification, and damage to the cytoskeleton is common across species...
- Lesions associated with Mycobacterium tuberculosis complex infection in the European wild boarMaría Paz Martín-Hernando
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
Tuberculosis (Edinb) 87:360-7. 2007..and distribution of lesions in 127 Mycobacterium tuberculosis Complex culture positive European wild boars (Sus scrofa), and use this information to discuss the role of this wildlife species in TB epidemiology in Mediterranean ..
- Genome-wide identification of quantitative trait loci for carcass composition and meat quality in a large-scale White Duroc x Chinese Erhualian resource populationJ Ma
Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
Anim Genet 40:637-47. 2009..White Duroc alleles at a majority of QTL detected were favourable for carcass composition, while favourable QTL alleles for meat quality originated from both White Duroc and Erhualian...
- Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosisPei Shiue J Tsai
Department of Farm Animal Health, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
PLoS ONE 7:e32603. 2012..The possibility to study separate and dynamic interactions between SNARE proteins, complexin and Ca(2+) which are all involved in AE make sperm an ideal model for studying exocytosis...
- L-carnitine enhances oocyte maturation and development of parthenogenetic embryos in pigsG Q Wu
Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
Theriogenology 76:785-93. 2011....
- Cognitive testing of pigs (Sus scrofa) in translational biobehavioral researchBirgitte R Kornum
Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, N9201, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen East, Denmark
Neurosci Biobehav Rev 35:437-51. 2011..However, most tasks have only been established at a single research facility, and would benefit from further validation. This review presents the cognitive tasks that have been developed for pigs, their validation, and their current use...
- Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistanceLina M Cavaco
Research Group for Antimicrobial Resistance and Molecular Epidemiology, National Food Institute, Technical University of Denmark, Copenhagen, Denmark
Vet Microbiol 150:344-8. 2011..This study showed that zinc resistance and the czrC gene are widespread among CC398 MRSA isolates. This suggests that the use of zinc in feed might have contributed to the emergence of MRSA...
- Quantitative trait loci for production traits in pigs: a combined analysis of two Meishan x Large White populationsY M Guo
Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
Anim Genet 39:486-95. 2008..There were also a number of significant interactions between detected QTL effects and population...
- Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigsCordelia Manickam
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
Vet Microbiol 162:68-77. 2013..The NK cell-mediated cytotoxicity was significantly reduced in infected pigs. In addition, increased population of immunosuppressive T-regulatory cells (Tregs) and associated cytokines were also observed in VR2332 strain infected pigs...
- African swine fever virus isolate, Georgia, 2007Rebecca J Rowlands
Institute for Animal Health, Pirbright, UK
Emerg Infect Dis 14:1870-4. 2008..One possibility for the spread of disease to Georgia is that pigs were fed ASFV-contaminated pork brought in on ships and, subsequently, the disease was disseminated throughout the region...
- Free-ranging wild boar: a disease threat to domestic pigs in Switzerland?Natacha Wu
Centre for Fish and Wildlife Health, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Postfach 8466, CH 3001 Bern, Switzerland
J Wildl Dis 47:868-79. 2011The risk of transmission of pathogens from free-ranging wild boars (Sus scrofa scrofa) to outdoor domestic pigs (S. scrofa domesticus) is of increasing concern in many European countries...
- Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosisChi Zhang
Department of Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA
Bone 48:507-13. 2011..We speculate that HIF-1α upregulation of Sox9 activity may have a chondroprotective role following femoral head ischemia...
- The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphismL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
J Anim Sci 88:2235-45. 2010..However, for practical applications, because the CTSD gene should not be imprinted (we obtained this information from expression analysis in adult skeletal muscle), the different modes of inheritance of the 2 genes have to be considered...
- Porcine T-helper and regulatory T cells exhibit versatile mRNA expression capabilities for cytokines and co-stimulatory moleculesTobias Käser
Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinarplatz 1, 1210 Vienna, Austria
Cytokine 60:400-9. 2012..In contrast, Tregs appear to fulfil mainly immunosuppressive functions characterized by increased production of IL-10, IL-35, CD40L, and CD25...
- Wild boars as an important reservoir for foodborne pathogensSilke Wacheck
Faculty of Veterinary Medicine, Institute of Food Hygiene and Technology, Ludwig Maximilians University, Munich, Germany
Foodborne Pathog Dis 7:307-12. 2010..This study shows that wild boars are frequent carriers of foodborne pathogens. High wild boar densities and increasing popularity of outdoor ranging of pigs may intensify the risk of transmission of these pathogens to fattening pigs...
- Tick-borne disease agents in various wildlife from MississippiAshley H Castellaw
Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
Vector Borne Zoonotic Dis 11:439-42. 2011..Whole blood and serum were tested from white-tailed deer (WTD; Odocoileus virginianus) and feral swine (Sus scrofa); serum was tested from raccoons (Procyon lotor) and opossums (Didelphis virginiana)...
- Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicityJianye Zhou
Thoracic, Cardiac and Vascular Surgery, University Hospital Tubingen, 72076 Tubingen, Germany
Biomaterials 31:2549-54. 2010..From our experiment, sodium deoxycholate enables cell removal with almost complete preservation of ECM structures. And all of these four decellularization protocols affected human immunological response and increased thrombogenicity...
- Identification of suitable endogenous control microRNA genes in normal pig tissuesYiren Gu
Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, China
Anim Sci J 82:722-8. 2011..We envision that these results will serve as a valuable reference for other studies aimed at measuring tissue-specific miRNA abundance in porcine samples...
- Whole-genome SNP association analysis of reproduction traits in the Finnish Landrace pig breedPekka Uimari
Agrifood Research Finland, MTT, Biotechnology and Food Research, Jokioinen, Finland
Genet Sel Evol 43:42. 2011..The purpose of this study was to identify SNP associated with reproduction traits in the Finnish Landrace pig breed using the Illumina PorcineSNP60 BeadChip...
- Anaplasma spp. in wild mammals and Ixodes ricinus from the north of SpainAranzazu Portillo
Área de Enfermedades Infecciosas Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Hospital San Pedro CIBIR, Logrono, Spain
Vector Borne Zoonotic Dis 11:3-8. 2011..Further, it seems that the Ap-variant 1 is circulating among I. ricinus ticks from the North of Spain more frequently than the A. phagocytophilum strain associated to human anaplasmosis...
- A review of viral diseases of the European wild boar: effects of population dynamics and reservoir rôleFrancisco Ruiz-Fons
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
Vet J 176:158-69. 2008..The focus is on those viral diseases of domestic swine and wild boars that are included as notifiable by the Office International des Epizooties (OIE)...
- Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern VietnamThi Hoa Ngo
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
PLoS ONE 6:e17943. 2011..suis serotype 2 capable of causing human infection in southern Vietnam. Strict hygiene at processing facilities, and health education programs addressing food safety and proper handling of pork should be encouraged...
- Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditionsMary Clapperton
The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, EH25 9PS, UK
Genet Sel Evol 41:54. 2009....
- Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune responseYu Gao
INRA, UMR 1313 de Génétique Animale et Biologie Intégrative, Domaine de Vilvert, 78350 Jouy en Josas, France
BMC Genomics 11:292. 2010..In order to address questions related to immunity and resistance to disease in pig, it is necessary to increase knowledge on its immune system and to produce efficient tools dedicated to this species...
- Two outbreaks of classical swine fever in wild boar in FranceF Pol
Agence Française de Sécurité Sanitaire des Aliments Laboratorie d Etudes et de Recherches Avicoles Porcines et Piscicoles Unité de Virologie et Immunologie Porcines, Laboratorie National de Référence pour les Pestes Porcines, Zoopole, Ploufragan, France
Vet Rec 162:811-6. 2008....
- Pathology of gastrointestinal organs in a porcine model of cystic fibrosisDavid K Meyerholz
Department of Pathology, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Am J Pathol 176:1377-89. 2010..Thus, mucus cell hyperplasia and mucus accumulation play prominent roles in early disease. Our findings also have implications for CF lung disease, and they lay the foundation for a better understanding of CF pathogenesis...
- Preventive vaccination contributes to control classical swine fever in wild boar (Sus scrofa sp.)S Rossi
Wildlife Sanitary Unit Unité Sanitaire de la Faune, Game and Wildlife Agency Office National de la Chasse et de la Faune Sauvage, 05000 Gap, France
Vet Microbiol 142:99-107. 2010..attenuated vaccine has been experimented in Europe in order to control classical swine fever (CSF) in Wild Boar (Sus scrofa sp.)...
- Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United StatesNahuel Fittipaldi
Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en Infectiologie Porcine, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC J2S 7C6, Canada
Vet Microbiol 139:310-7. 2009..On the other hand, our results for the U.S. S. suis isolates are similar to those reported for Canadian strains, suggesting a common status in North America...
- Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be importantR Michael Roberts
Division of Animal Sciences, University of Missouri, Columbia, MO, USA
Cell Cycle 8:3078-81. 2009....
- Immunohistochemical study of pig retinal developmentJasenka Guduric-Fuchs
Centre for Vision and Vascular Sciences, Queen s University Belfast, United Kingdom
Mol Vis 15:1915-28. 2009..The purpose of this study was to characterize retinal histology in the developing and mature pig retina using antibodies to well established retinal cell markers commonly used in rodents...
- Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigsNam Soo Joo
Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
J Clin Invest 120:3161-6. 2010..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
- Identification of QTL with effects on intramuscular fat content and fatty acid composition in a Duroc x Large White crossMarie Pierre Sanchez
INRA, UR337 Station de Génétique Quantitative et Appliquée, F 78350 Jouy en Josas, France
BMC Genet 8:55. 2007..The detection was performed in an experimental F2 Duroc x Large White population first by segregation analysis, then by QTL mapping using additional molecular information...
- MicroRNA expression profiles of porcine skeletal muscleB Zhou
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, No 1 Weigang, Nanjing, China
Anim Genet 41:499-508. 2010..These results provide a valuable resource for investigators interested in post-transcriptional gene regulation in pigs and related animals...
- Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eyeAngus Macneil
Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL UK
Stem Cells 25:2430-8. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boarHiroyuki Matsuda
J Infect Dis 188:944. 2003
- MicroRNA identity and abundance in developing swine adipose tissue as determined by Solexa sequencingGuoxi Li
Laboratory of Animal Fat Deposition and Muscle Development, Northwest A and F University, Yangling, Shaanxi Province 712100, PR China
J Cell Biochem 112:1318-28. 2011..Our results expand the number of known porcine miRNAs and provide a thorough account of the miRNA transcriptome in porcine adipose tissue...
- Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryosChi Hun Park
SooAm Biotech Research Foundation, Seoul, Republic of Korea
PLoS ONE 6:e22216. 2011..In addition we believe that imprinted expression occurs in at least four genes, namely H19, IGF2, XIST and PEG10 in porcine blastocyst stage embryos...
- Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharideRonan Kapetanovic
The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
J Immunol 188:3382-94. 2012..These results establish pig BMDM as an alternative tractable model for the study of macrophage transcriptional control...
- Mitochondrial haplotypes of European wild boars with 2n = 36 are closely related to those of European domestic pigs with 2n = 38M Fang
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24 Uppsala, Sweden
Anim Genet 37:459-64. 2006....
- XMAP215 is a processive microtubule polymeraseGary J Brouhard
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Cell 132:79-88. 2008..The similarities between XMAP215 and formins, actin polymerases, suggest that processive tip tracking is a common mechanism for stimulating the growth of cytoskeletal polymers...
- Comparison of luteinizing hormone and steroid hormone secretion during the peri- and post-ovulatory periods in Mangalica and Landrace giltsIstvan Egerszegi
Research Institute for Animal Breeding and Nutrition, 2053 Herceghalom, Gesztenyés út 1, Hungary
J Reprod Dev 49:291-6. 2003..17.8 +/- 5.0, P<0.05). In our experiment, there was no evidence that differences in the secretion of analysed hormones during the peri- and post-ovulatory periods are a possible cause of usually lower fecundity in Mangalica gilts...
- Bovine tuberculosis in wild boar (Sus scrofa), red deer (Cervus elaphus) and cattle (Bos taurus) in a Mediterranean ecosystem (1992-2004)J Hermoso De Mendoza
Patología Infecciosa, Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain
Prev Vet Med 74:239-47. 2006..These findings, as well as recent history of game estates management and descriptive epidemiology field work, throw light on the rise and maintenance of these epizootics...
- Persistence of pseudorabies virus in feral swine populationsJoseph L Corn
Southeastern Cooperative Wildlife Disease Study, University of Georgia, Athens 30602, USA
J Wildl Dis 40:307-10. 2004..Consistent results from latex agglutination tests conducted in the field and laboratory demonstrated that this test was useful as a rapid and reliable diagnostic tool when used in the field...
- Porcine induced pluripotent stem cells produce chimeric offspringFranklin D West
Regenerative Bioscience Center, University of Georgia, Athens, Georgia 30602, USA
Stem Cells Dev 19:1211-20. 2010....
- Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis in Eurasian wild boar (Sus scrofa scrofa)Mariana Boadella
IREC National Wildlife Research Institute CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
J Vet Diagn Invest 23:77-83. 2011New tools to detect exposure of free-range Eurasian wild boar (Sus scrofa scrofa) to pathogenic mycobacteria would be valuable for improved disease surveillance and wildlife management...
- Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association studyKyung Tai Lee
Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Suwon, Republic of Korea
PLoS ONE 6:e16356. 2011..These results provide strong support for a major involvement of the CNS in the genetic predisposition to a common form of obesity...
- Molecular identification of Trichuris vulpis and Trichuris suis isolated from different hostsCristina Cutillas
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Sevilla, Profesor García González s n, Sevilla, Spain
Parasitol Res 100:383-9. 2007Trichuris suis was isolated from the cecum of two different hosts (Sus scrofa domestica -- swine and Sus scrofa scrofa -- wild boar) and Trichuris vulpis from dogs in Sevilla, Spain...
- Retrospective analysis of the oral immunisation of wild boar populations against classical swine fever virus (CSFV) in region Eifel of Rhineland-PalatinateStefan von Rüden
Institute for Virology, University of Veterinary Medicine Hannover, Hannover, Germany
Vet Microbiol 132:29-38. 2008..The last virus-positive pig was found 13 months after start of o.i...
- The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42100 Reggio Emilia, Italy
Anim Genet 40:90-3. 2009..00001, P<0.001 and P<0.0001, considering all animals or only two- or three-generation unrelated animals respectively), indicating association between the analysed FTO marker and intermuscular fat deposition...
- Antimicrobial-resistant faecal Escherichia coli in wild mammals in central Europe: multiresistant Escherichia coli producing extended-spectrum beta-lactamases in wild boarsI Literak
Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
J Appl Microbiol 108:1702-11. 2010..To determine the presence of antibiotic-resistant faecal Escherichia coli in populations of wild mammals in the Czech Republic and Slovakia...
- Gene expression profiles of European wild boar naturally infected with Mycobacterium bovisRuth C Galindo
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ciudad Real, Spain
Vet Immunol Immunopathol 129:119-25. 2009..Gene expression studies in naturally infected wildlife reservoirs of bovine tuberculosis are important for functional genomics and vaccine studies to aid in disease control in wildlife...
- Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertensionTitus Kuehne
Department of Congenital Heart Diseases and Pediatric Cardiology, German Heart Institute, Augustenburger Platz 1, Berlin 13353 Germany
Circulation 110:2010-6. 2004....
- Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imagingRainer Petzina
Department of Medicine, Lund University Hospital, Lund, Sweden
J Thorac Cardiovasc Surg 133:1154-62. 2007....
- Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell TechnologyKelvin Brockbank; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis ModelAliye Uc; Fiscal Year: 2010..We produced pigs (Sus scrofa) with a targeted disruption of both cystic fibrosis transmembrane conductance regulator (CFTR) alleles...
- Biomechanical and Molecular Mechanisms in Alveolar Bone DevelopmentTRACY POPOWICS; Fiscal Year: 2008..these experimental conditions. Taken together, these studies will provide fundamental new information about how tooth loading modifies alveolar bone in newly erupted teeth and promotes adaptive tooth support. ..
- CRYOPRESERVATION OF ARTICULAR CARTILAGE BY VITRIFICATIONKelvin Brockbank; Fiscal Year: 2003..The U.S. market for cartilage repair products is predicted to exceed 90,000 units and $248 million in the near future. ..
- Engineered Cartilage Storage and Transport SolutionKelvin Brockbank; Fiscal Year: 2005..These studies will lead to the development and commercialization of Unisol formulations specifically designed for cold storage of tissue engineered cartilage constructs. ..
- Freeze-Dried, Viable Allogeneic Heart ValvesKelvin Brockbank; Fiscal Year: 2006..unreadable] [unreadable]..
- Feasibility of Unfrozen Sub-zero Storage of Mammalian Tissues with Insect Anti-FrKelvin Brockbank; Fiscal Year: 2008....
- Feasibility of Hypothermic Liver PerfusionKelvin Brockbank; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- IMPROVED ALLOGRAFT HEART VALVE PRESERVATIONKelvin Brockbank; Fiscal Year: 2003..It is anticipated that modification or reduction of ice formation in cryopreserved valves should decrease the need for reoperation due to structural deterioration and calcification in allograft recipients. ..
- BONE GROWTH, PERIOSTEAL MIGRATION AND MUSCLE FUNCTIONSusan Herring; Fiscal Year: 2007..unreadable] [unreadable]..
- MECHANICAL ENVIRONMENT IN MANDIBULAR DISTRACTIONSusan Herring; Fiscal Year: 2006....
- Quantitating Absorption of Complex Chemical MixturesJim Riviere; Fiscal Year: 2009..abstract_text> ..
- Plasminogen activators and cerebral ischemic injuryWilliam M Armstead; Fiscal Year: 2010....
- NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIAOm Mishra; Fiscal Year: 2008..abstract_text> ..
- POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAINWilliam Armstead; Fiscal Year: 2005..These studies may lead to therapies for brain injured children. ..
- NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIAOm Mishra; Fiscal Year: 2006..abstract_text> ..
- Nitric Oxide Tolerance in Smooth MuscleWilliam Perkins; Fiscal Year: 2005..We will use a combination of pharmacological probes and novel antisense oligomers to determine the mechanism by which chronic NO treatment decreases the expression and activity of sGC subunits and cGK isoforms. ..
- Ischemic Arrest, Cytokines, and Organ DysfunctionJames Niemann; Fiscal Year: 2008..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
- Arginine and Ovine Model for Fetal Growth RestrictionGuoyao Wu; Fiscal Year: 2007..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
- Reproduction of Transgenic Pigs by Nuclear TransplantationRandall S Prather; Fiscal Year: 2010..of DNA methylation changes during development will provide clues as to the process of imprinting in Sus scrofa. To that end we propose to bring to bear the most relevant technologies into a systems or integrated approach, i...
- STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLsStephen Nakada; Fiscal Year: 2005..abstract_text> ..
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- TRPV4 Initiates Ventilator Induced Lung InjuryJames C Parker; Fiscal Year: 2010..and that lung PAR1 and PAR2 activation peptidesincrease lung vascular permeability in TRPV4+/+ mice ventilated with high airway pressures but not in TRPV4-/- mice, or either genotype ventilated with low airway pressures ..
- Enhanced Primary Repair of Ligament InjuriesMartha Murray; Fiscal Year: 2008..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
- Formation of the Enamel-Dentin InterfaceElia Beniash; Fiscal Year: 2010..abstract_text> ..
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
- Improved MRI techniques for measurement of absolute temperature distributionsNICHOLAS TODD; Fiscal Year: 2008..A temporally constrained reconstruction algorithm has been shown to be capable of reducing scan time and can also be implemented with any pulse sequence. [unreadable] [unreadable] [unreadable]..
- ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCYMartin Ronis; Fiscal Year: 2006..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
- Bridges to the Doctorate in Reproductive BiologyFuller Bazer; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUMROBERT MICHAEL ROBERTS; Fiscal Year: 2010..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
- Improving Institutional Animal Resources at MUSCMARVIN SWINDLE; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Pulsed Electron Avalanche Knife: Intraocular Microsurg.Daniel Palanker; Fiscal Year: 2006..The low cost and small size of this system combined with high precision, reliability and versatility should allow for a widespread acceptance into operating practice. ..
- Relationship between diet and sex of offspringRobert Roberts; Fiscal Year: 2008..abstract_text> ..
- Light dosimetry for esophageal photodynamic therapyLinda Jones; Fiscal Year: 2007..As esophageal photodynamic therapy is improved, it is likely to be used more often as an alternative to esophagectomy. [unreadable] [unreadable] [unreadable]..
- Prostanoids and hypoxic neonatal pulmonary hypertensionCANDICE FIKE; Fiscal Year: 2009..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
- Mechanical Injury to Lung EndotheliumJames Parker; Fiscal Year: 2001....
- MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMELJohn Bartlett; Fiscal Year: 2006..This application builds on results from a highly productive R29 grant (DE12098). ..
- Role of CRH in skin physiology and pathologyAndrzej Slominski; Fiscal Year: 2004..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
- DEVELOPING BSL3 ANIMAL FACILITIES AT MUSCMARVIN SWINDLE; Fiscal Year: 2004..The facility will be in full compliance with CDC and NIH regulations for performing this type of research. ..
- JEOL 1230 TEM and BOC Edwards Vacuum EvaporatorMichael Welsh; Fiscal Year: 2004..McCray will be involved with gene transfer using lentiviral vectors. Tobacman will study the structure of short actin filaments. Zabner will examine the morphology of Adeno-associated virus. ..
- High Intensity Ultrasound in GastroenterologyJOO HWANG; Fiscal Year: 2003..It is anticipated that this work will help to gain a better understanding of the mechanisms of HIFU and its potential role for other GI applications such as tumor therapy. ..
- IMPROVING INSTITUTIONAL ANIMAL RESOURCESMARVIN SWINDLE; Fiscal Year: 2003....
- OVARIAN LDL RECEPTOR AND STAR GENE REGULATIONHOLLY LAVOIE; Fiscal Year: 2003..These studies will promote our understanding of how multiple genes are coordinated by different trophic factors in the ovary during follicular differentiation and add to our understanding of mechanisms of infertility. ..
- HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIAChangyi Chen; Fiscal Year: 2002....
- AIRWAY PERFUSION ASSISTED LIQUID VENTILATORJames Parker; Fiscal Year: 2002..Other applications include continuous intrapulmonary administration of drugs and anesthetics and clearance of material from the lungs...
- SERPIN-PROTEASE REACTION, HYDRATION AND GEOMETRY CHANGESMaria McGee; Fiscal Year: 2002..This information will serve to develop therapies to prevent and control thromboembolic complications of cardiovascular disease. ..
- OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTORFuller Bazer; Fiscal Year: 2005....
- ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUSXiang Jin Meng; Fiscal Year: 2001..abstract_text> ..
- ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIETMartin Ronis; Fiscal Year: 2005....
- Regulation of Fibroblast Survival in the Collagen MatrixMark Carlson; Fiscal Year: 2005..Loss of matrix anchorage is hypothesized to reverse these effects and induce apoptosis. The involvement of each protein will be probed with mutated isoforms. ..
- Selectins and Fetal wound HealingOluyinka Olutoye; Fiscal Year: 2007..These may then provide opportunities to assist with the inflammatory responses in these children when they are most vulnerable. ..
- Effects of Myostatin Deficiency on Bone StrengthMark Hamrick; Fiscal Year: 2007..abstract_text> ..
- A Novel Mechanism for Intra-articular NonunionMartha M Murray; Fiscal Year: 2010....
- Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic CancerChangyi Chen; Fiscal Year: 2008..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
- PRESERVATION OF LIVER SLICES BY VITRIFICATIONMichael Taylor; Fiscal Year: 2005..The molecular ice control formulations which provide the highest tissue viability and least interstitial ice formation will be tested in larger animal and human PCLS tissues in a sub-sequent Phase II SBIR proposal. ..
- ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSIONChangyi Chen; Fiscal Year: 2002....
- Pancreas Transporter Development and ValidationMichael Taylor; Fiscal Year: 2006..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
- MOLECULAR ICE CONTROL FOR ENGINEERED TISSUESMichael Taylor; Fiscal Year: 2003..The potential markets are enormous. Cryopreservation methods, which result in retained viability and function, will be licensed to the tissue engineering industry. ..
- Cerebral Microvascular Endothelin ProductionMomoh Yakubu; Fiscal Year: 2003..Our understanding of the mechanisms underlying the consequences of SAH will make it possible for early and appropriate intervention to prevent or reduce these complications from hemorrhagic stroke. ..
- Effects of HAART drugs on endothelial dysfunction of pu*Changyi Chen; Fiscal Year: 2009..abstract_text> ..
- HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTIONChangyi Chen; Fiscal Year: 2004..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
- Transcription Factors in Trophectoderm DifferentiationRobert Roberts; Fiscal Year: 2007..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
- Molecular Surgeon Symposium on Vascular Injury, RepairChangyi Chen; Fiscal Year: 2005..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
- Tissue engineering of small diameter vascular graftChangyi Chen; Fiscal Year: 2006..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
- Effects of HIV Protease Inhibitors of Endothelial BarrieChangyi Chen; Fiscal Year: 2005..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
- Induced hypothermic arrest in traumatic shockHasan Alam; Fiscal Year: 2005..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
- VSV RNA TRANSCRIPTION AND REPLICATIONASIT PATTNAIK; Fiscal Year: 2005..These studies are of major importance for an understanding of the mechanisms of the viral gene expression and virus growth. ..