Genomes and Genes
Summary: Common name for a family of eel-shaped jawless fishes (Myxinidae), the only family in the order MYXINIFORMES. They are not true vertebrates.
Publications186 found, 100 shown here
- Fossil sister group of craniates: predicted and foundJon Mallatt
School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
J Morphol 258:1-31. 2003..By contrast, Haikouella does not fit the widespread belief that ancestral craniates resembled hagfishes, because it has no special hagfish characters...
- microRNAs reveal the interrelationships of hagfish, lampreys, and gnathostomes and the nature of the ancestral vertebrateAlysha M Heimberg
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 107:19379-83. 2010....
- Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfishKinya G Ota
Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
Nat Commun 2:373. 2011..We conclude that the vertebra-like elements in the hagfish are homologous to gnathostome vertebrae, implying that this animal underwent secondary reduction of vertebrae in most of the trunk...
- Overview of the transcriptome profiles identified in hagfish, shark, and bichir: current issues arising from some nonmodel vertebrate taxaMasaki Takechi
Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Kobe, Japan
J Exp Zool B Mol Dev Evol 316:526-46. 2011Because of their crucial phylogenetic positions, hagfishes, sharks, and bichirs are recognized as key taxa in our understanding of vertebrate evolution...
- Insights into cyclostome phylogenomics: pre-2R or post-2RShigehiro Kuraku
Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
Zoolog Sci 25:960-8. 2008..in accumulating genomic and transcriptomic sequence data for the earliest groups of extant vertebrates, namely, hagfishes (Myxiniformes) and lampreys (Petromyzontiformes)...
- Comparative anatomy: all vertebrates do have vertebraePhilippe Janvier
Museum national d histoire naturelle, UMR 7207, CP38, 8, rue Buffon 75231, Paris Cedex 05, France
Curr Biol 21:R661-3. 2011In contrast to lampreys and jawed vertebrates, hagfishes were thought to lack vertebrae...
- Molecular phylogeny of early vertebrates: monophyly of the agnathans as revealed by sequences of 35 genesNaoko Takezaki
Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
Mol Biol Evol 20:287-92. 2003Extant vertebrates are divided into three major groups: hagfishes (Hyperotreti, myxinoids), lampreys (Hyperoartia, petromyzontids), and jawed vertebrates (Gnathostomata)...
- Palaeophylogenomics of the vertebrate ancestor--impact of hidden paralogy on hagfish and lamprey gene phylogenyShigehiro Kuraku
Laboratory for Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, Universitatsstrasse 10, 78464 Konstanz, Germany
Integr Comp Biol 50:124-9. 2010..To date, as the most early-branching lineages in vertebrates, cyclostomes (hagfishes and lampreys) have been used for comparative analyses of gene regulations and functions...
- Early jawless vertebrates and cyclostome originsPhilippe Janvier
Museum national d histoire naturelle, Departement Histoire de la Terre, UMR 5143 du CNRS, CP 38, 57 rue Cuvier, 75231 Paris Cedex 05, France
Zoolog Sci 25:1045-56. 2008Undoubted fossil lampreys are recorded since the Late Devonian (358 Ma), and probable fossil hagfishes since the Late Carboniferous (300 Ma), but molecular clock data suggest a much earlier divergence times for the two groups...
- Time scale for cyclostome evolution inferred with a phylogenetic diagnosis of hagfish and lamprey cDNA sequencesShigehiro Kuraku
Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
Zoolog Sci 23:1053-64. 2006The Cyclostomata consists of the two orders Myxiniformes (hagfishes) and Petromyzoniformes (lampreys), and its monophyly has been unequivocally supported by recent molecular phylogenetic studies...
- 28S and 18S rDNA sequences support the monophyly of lampreys and hagfishesJ Mallatt
Department of Zoology, Washington State University, Pullman 99164 4236, USA
Mol Biol Evol 15:1706-18. 1998Resolving the interrelationships of three major extant lineages of vertebrates (hagfishes, lampreys, and gnathostomes) is a particularly important issue in evolution, because the basal resolution critically influences our understanding ..
- Expression pattern of two collagen type 2 alpha1 genes in the Japanese inshore hagfish (Eptatretus burgeri) with special reference to the evolution of cartilaginous tissueKinya G Ota
Laboratory for Evolutionary Morphology, Center for Developmental Biology, Minatojima Minami, Chuo, Kobe, Hyogo, Japan
J Exp Zool B Mol Dev Evol 314:157-65. 2010..origin of Col2A1 has been studied at the biochemical and molecular levels in extant jawless vertebrates (hagfishes and lampreys)...
- Developmental biology of hagfishes, with a report on newly obtained embryos of the Japanese inshore hagfish, Eptatretus burgeriKinya G Ota
Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minami, Chuo, Kobe, Hyogo 650 0047, Japan
Zoolog Sci 25:999-1011. 2008The apparently primitive features of hagfishes are recognized as a crucial problem in the study of vertebrate evolution, although the monophyletic relationship between these animals and lampreys has been confirmed by large amounts of ..
- Hagfish (cyclostomata, vertebrata): searching for the ancestral developmental plan of vertebratesShigeru Kuratani
Evolutionary Morphology Research Group, Center for Developmental Biology, RIKEN, Kobe, Japan
Bioessays 30:167-72. 2008..We conclude that the delaminating neural crest is a vertebrate synapomorphy that seems to have appeared from the beginning of their evolutionary history, before the splitting away of the hagfish lineage...
- Schreiner organs: a new craniate chemosensory modality in hagfishesC B Braun
Department of Neurosciences, University of California at San Diego, La Jolla 92093 0201, USA
J Comp Neurol 392:135-63. 1998An extensive system of sensory organs resembling taste buds was previously known in the skin of hagfishes. These sensory organs, called here Schreiner organs, are found throughout the epidermis of both Eptatretus stoutii and Myxine ..
- Craniofacial development of hagfishes and the evolution of vertebratesYasuhiro Oisi
Department of Biology, Graduate School of Science, Kobe University, Kobe 657 8501, Japan
Nature 493:175-80. 2013Cyclostomes, the living jawless vertebrates including hagfishes and lampreys, represent the most basal lineage of vertebrates...
- Evolutionary biology: born-again hagfishesPhilippe Janvier
Nature 446:622-3. 2007
- An alternative model for the structural mechanics of hagfish slime threadsJ W S Hearle
School of Materials, University of Manchester, M60 1QD, UK
Int J Biol Macromol 42:420-8. 2008..The behaviour of the total thread/mucus/water system is discussed and some speculations on the defensive mechanisms that have evolved are presented...
- Comparison of the biochemical composition of normal epidermal mucus and extruded slime of hagfish (Myxine glutinosa L.)S Subramanian
Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
Fish Shellfish Immunol 25:625-32. 2008..The observation of elevated levels of innate immune parameters in the extruded slime suggested that the extruded slime has a significant role in innate immunity of hagfish against infectious pathogens...
- Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebratesGuangjun Zhang
Department of Zoology, University of Florida, P O Box 118525, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 103:16829-33. 2006..Here, we investigate the origin of vertebrate cartilage, and we report that hagfishes, the sister group to lampreys, also have Col2alpha1-based cartilage, suggesting its presence in the common ..
- Stabilization and swelling of hagfish slime mucin vesiclesJ E Herr
Department of Integrative Biology, University of Guelph, Guelph, ON N1G 2W1 Canada
J Exp Biol 213:1092-9. 2010..This suggests that some other mechanism such as the chemical microenvironment within gland mucous cells, or hydrostatic pressure is responsible for stabilization of the vesicles within the gland...
- A degenerate ParaHox gene cluster in a degenerate vertebrateRebecca F Furlong
Department of Zoology, Oxford University, Oxford, United Kingdom
Mol Biol Evol 24:2681-6. 2007..Here, we report the mapping of a ParaHox gene cluster in 2 species of hagfishes. Unexpectedly, these basal vertebrates have lost a functional Xlox gene from this cluster, unlike every other ..
- Hagfish slime ecomechanics: testing the gill-clogging hypothesisJeanette Lim
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC, V6T 1Z4, Canada
J Exp Biol 209:702-10. 2006..We suggest that the loose binding of water by the slime may be an optimal solution to the problem of delivering an expanding jet of flow-inhibiting material to the gills of would-be predators...
- The history of scientific endeavors towards understanding hagfish embryologyKinya G Ota
Laboratory for Evolutionary Morphology, Center for Developmental Biology CDB, RIKEN
Zoolog Sci 23:403-18. 2006Due to their curious phylogenetic position and anatomy, hagfishes have attracted the interest of zoologists, especially in the context of vertebrate evolution...
- Composition, morphology and mechanics of hagfish slimeDouglas S Fudge
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC V6T 1Z4, Canada
J Exp Biol 208:4613-25. 2005..Our results suggest that hagfishes can produce remarkable quantities of the slime because it is almost three orders of magnitude more dilute than ..
- Morphology and kinematics of feeding in hagfish: possible functional advantages of jawsAndrew J Clark
Evolutionary and Comparative Physiology, Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697 2525, USA
J Exp Biol 210:3897-909. 2007..Hagfish gape cycle times are approximately 1 s, and are longer than those of gnathostomes, suggesting that a functional advantage of jaws is the speed that allows gnathostomes to exploit elusive prey...
- Deployment of hagfish slime thread skeins requires the transmission of mixing forces via mucin strandsT M Winegard
Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
J Exp Biol 213:1235-40. 2010b>Hagfishes are benthic marine protovertebrates that secrete copious quantities of slime when threatened...
- Hagfish embryology with reference to the evolution of the neural crestKinya G Ota
Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
Nature 446:672-5. 2007....
- Evolutionary implications of lactate dehydrogenases (LDHs) of hagfishes compared to lampreys: LDH cDNA sequences from Eptatretus burgeri, Paramyxine atami and Eptatretus okinoseanusYoshikazu Nishiguchi
Department of Pharmaceutical Practice, Faculty of Pharmaceutical Science, Toho University, Chiba, Japan
Zoolog Sci 25:475-9. 2008Heart muscles of hagfishes Paramyxine atami and Eptatretus okinoseanus express the B4 isozyme of lactate dehydrogenase [L-LDH: NAD oxidoreductase, EC 188.8.131.52] (LDH-B4) whereas their skeletal muscles express LDH-A4...
- The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebratesG M Wright
Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
Cell Tissue Res 304:165-74. 2001..A least two types of non-collagenous cartilage matrix proteins are found in both the hagfishes and the lampreys, all of which are resistant to digestion by cyanogen bromide (CNBr)...
- The complete mitochondrial genome of the hagfish Myxine glutinosa: unique features of the control regionC Delarbre
Unité de Biologie Moléculaire du Gène, Departement d Immunologie, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
J Mol Evol 53:634-41. 2001..The comparison of the mtDNAs of two M. glutinosa specimens, excluding the control region, shows a 0.6% divergence at the nucleotide level as a sample of intraspecies polymorphism...
- Excitation-contraction coupling in skeletal and caudal heart muscle of the hagfish Eptatretus burgeri GirardIsao Inoue
The Ine Marine Laboratory of National Institute for Physiological Sciences, Ine, Kyoto 626 0424, Japan
J Exp Biol 205:3535-41. 2002b>Hagfishes are regarded as the most primitive living craniates. Excitation-contraction (E-C) coupling mechanisms were studied in skeletal and caudal heart muscle fibres of the hagfish Eptatretus burgeri...
- Hagfish intestinal antimicrobial peptides are ancient cathelicidinsThomas Uzzell
Academy of Natural Sciences, 1900 Benjamin Franklin Parkway, Philadelphia, PA 19103, USA
Peptides 24:1655-67. 2003..We suggest that this tissue organization provides local defense of the hagfish gastrointestinal tract via innate immunity and possibly served as the architectural plan upon which the adaptive immune system evolved...
- Long-term inheritance of the 28S rDNA-specific retrotransposon R2Kenji K Kojima
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan
Mol Biol Evol 22:2157-65. 2005..This study revealed the long-term vertical inheritance and the ancient origin of sequence specificity of R2, both of which seem applicable to some other non-LTR retrotransposons...
- Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypesTatjana Haitina
Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, Uppsala, Sweden
BMC Evol Biol 7:101. 2007..They belong to the rhodopsin family of G protein-coupled receptors (GPCRs). The purpose of this study was to identify ancestral MC receptors in agnathan, river lamprey...
- Evidence for independent Hox gene duplications in the hagfish lineage: a PCR-based gene inventory of Eptatretus stoutiiPeter F Stadler
Lehrstuhl für Bioinformatik, Institut fur Informatik, Universitat Leipzig, Kreuzstrasse 7b, D 04103 Leipzig, Germany
Mol Phylogenet Evol 32:686-94. 2004..In this paper we report the results of a PCR survey on genomic DNA of the pacific hagfish Eptatretus stoutii. Hagfishes are one of two clades of recent jawless fishes that are an offshoot of the early radiation of jawless ..
- cDNA cloning of a mannose-binding lectin-associated serine protease (MASP) gene from hagfish (Eptatretus burgeri)Liqiu Song
Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Ujina higashi, Hiroshima 734 8558, Japan
Zoolog Sci 22:897-904. 2005..This evidence strongly suggests that the hagfish defends itself against pathogens at least by the complement system composed of lectin pathway...
- Nebulin is a thin filament protein of the cardiac muscle of the agnathansUlrike Fock
Biochemical Cell Biology, Faculty of Biology, University of Bielefeld, D 33501 Bielefeld, Germany
J Muscle Res Cell Motil 23:205-13. 2002..This clearly shows that nebulin is not exclusively present in skeletal muscles of chordates. The findings also demonstrate a rare case of dramatic size reduction of a protein during evolution...
- Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist EritoranHo Min Kim
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon, Korea 305 701
Cell 130:906-17. 2007..The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS...
- Evolution of skeletal type e-c coupling: a novel means of controlling calcium deliveryValentina Di Biase
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104
J Cell Biol 171:695-704. 2005..Our results show that a significant structural transition marks the protochordate to the Craniate evolutionary step, with the appearance of skeletal muscle-specific RyR and DHPR isoforms...
- Genes coding for intermediate filament proteins closely related to the hagfish "thread keratins (TK)" alpha and gamma also exist in lamprey, teleosts and amphibiansMichael Schaffeld
Institute of Zoology, Johannes von Müller Weg 6, Johannes Gutenberg University, D 55099 Mainz, Germany
Exp Cell Res 312:1447-62. 2006....
- Molecular cloning and structural characterization of the hagfish proteinase inhibitor of the alpha-2-macroglobulin familyAlimjan Idiris
Laboratory of Biodynamics, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
J Protein Chem 22:89-98. 2003..This implies that the specific subunit cleavage at Arg833 was caused by an unknown arginine specific proteinase which escaped from the entrapment by the hagfish inhibitor...
- Variable lymphocyte receptors in hagfishZeev Pancer
Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 102:9224-9. 2005..The development of two very different strategies for receptor diversification at the dawn of vertebrate evolution approximately 500 million years ago attests to the fitness value of a lymphocyte-based system of anticipatory immunity...
- Elements of the major myofibrillar binding peptide motif are present in the earliest of true muscle type creatine kinasesKouji Uda
Laboratory of Biochemistry, Faculty of Science, Kochi University, Kochi 780 8520, Japan
Int J Biochem Cell Biol 36:785-94. 2004....
- Transcriptome analysis of hagfish leukocytes: a framework for understanding the immune system of jawless fishesTakashi Suzuki
Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies Sokendai, Shonan Village, Hayama 240 0193, Japan
Dev Comp Immunol 28:993-1003. 2004..In total, our work provides circumstantial evidence that adaptive immunity is unique to jawed vertebrates...
- Evolution of hormone-receptor complexity by molecular exploitationJamie T Bridgham
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
Science 312:97-101. 2006..Our results indicate that tight interactions can evolve by molecular exploitation-recruitment of an older molecule, previously constrained for a different role, into a new functional complex...
- Why did the acquired immune system of vertebrates evolve?Jens Rolff
Animal and Plant Sciences, University of Sheffield, S10 2TN, Sheffield, UK
Dev Comp Immunol 31:476-82. 2007..These combine to shape a powerful multi-level and multi-causal selective scenario that I propose could have moulded the acquired immune system...
- Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-likeChiaki Haruta
Department of Pathology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060 8638, Japan
Immunogenetics 58:216-25. 2006..Phylogenetic analysis indicates that among known proteins, NICIR is most closely related to the lamprey molecule recently proposed to be a potential ancestor of T cell receptors...
- Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunityPauline M Cupit
Sars International Centre for Marine Molecular Biology, High Technology Centre, Bergen, Norway
J Immunol 171:6006-13. 2003..glutinosa behaves as a true Ikaros family member. Taken together, these results indicate that the properties associated with the Ikaros family preceded the emergence of the jawed vertebrates and thus adaptive immunity...
- Molecular characterization of water-selective AQP (EbAQP4) in hagfish: insight into ancestral origin of AQP4Goro Nishimoto
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
Am J Physiol Regul Integr Comp Physiol 292:R644-51. 2007..These observations suggest that EbAQP4 is an ancestral water channel of mammalian AQP4 and plays a role in basolateral water transport in the gill pavement cells...
- Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptorsTakashi Suzuki
Department of Biosystems Science, School of Advanced Sciences, Graduate University for Advanced Studies SOKENDAI, Hayama, Japan
J Immunol 174:2885-91. 2005..The extracellular domain of APAR may be descended from a V-type domain postulated to have acquired recombination signal sequences in a jawed vertebrate lineage...
- Structural diversity of the hagfish variable lymphocyte receptorsHo Min Kim
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
J Biol Chem 282:6726-32. 2007....
- Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolutionHector Escriva
CNRS UMR 5665, Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale Superieure de Lyon, Lyon Cedex, France
Mol Biol Evol 19:1440-50. 2002..Thus, the complexity of all the paralogy groups present in vertebrates should be explained by the contribution of genome duplications (2R hypothesis), extra gene duplications, and gene losses...
- A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phylaG S Begley
Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
J Biol Chem 275:36245-9. 2000..The vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid appears to be a highly conserved function in the animal kingdom...
- Hagfish hemoglobins: structure, function, and oxygen-linked associationA Fago
Department of Zoophysiology, University of Aarhus, Bldg. 131, Universitetsparken, DK 8000 Aarhus C, Denmark
J Biol Chem 276:27415-23. 2001Cyclostomes, hagfishes and lampreys, contain hemoglobins that are monomeric when oxygenated and polymerize to dimers or tetramers when deoxygenated...
- The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and vertebrate phylogenyA S Rasmussen
Department of Genetics, University of Lund, Sweden
J Mol Evol 46:382-8. 1998..Extant agnathans are represented by hagfishes (Myxiniformes) and lampreys (Petromyzontiformes), frequently grouped together within the Cyclostomata...
- Structural evolution of Otx genes in craniatesA Germot
Equipe ATIPE de l UPRES A 8080 Développement et Evolution, Orsay, France
Mol Biol Evol 18:1668-78. 2001..This suggests that specialized functions for each of these orthology classes were fixed in the gnathostome lineage prior to the splitting between osteichthyans and chondrichthyans...
- Evolution of a core gene network for skeletogenesis in chordatesJochen Hecht
BCRT, Universitätsmedizin Charité, Berlin, Germany
PLoS Genet 4:e1000025. 2008..The similarities in expression patterns of Runt genes support the view that teeth and placoid scales evolved from a homologous developmental module...
- Pressure-adaptive differences in lactate dehydrogenases of three hagfishes: Eptatretus burgeri, Paramyxine atami and Eptatretus okinoseanusYoshikazu Nishiguchi
Faculty of Pharmaceutical Science, Toho University, Toho, Japan
Extremophiles 12:477-80. 2008..We compared the activities of lactate dehydrogenase (LDH), an important enzyme in glycolytic reaction, in three hagfishes inhabiting different depths under increased pressure...
- Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptideN Nakashima
Department of Biology, Faculty of Science, Ochanomizu University, Tokyo, Japan
Biochim Biophys Acta 1120:1-10. 1992..Almost all of these vitronectin-like proteins showed marked species-specific variations in their apparent molecular weights from 51 to 96 kDa in SDS-PAGE...
- Complete mitochondrial DNA of the hagfish, Eptatretus burgeri: the comparative analysis of mitochondrial DNA sequences strongly supports the cyclostome monophylyChristiane Delarbre
Unité de Biologie Moléculaire du Gène, Institut Pasteur, Paris, France
Mol Phylogenet Evol 22:184-92. 2002The phylogenetic position of cyclostomes, i.e., the relationships between hagfishes, lampreys, and jawed vertebrates is an unresolved problem...
- Evolution of prothrombin: isolation and characterization of the cDNAs encoding chicken and hagfish prothrombinD K Banfield
Department of Biochemistry, University of British Columbia, Vancouver, Canada
J Mol Evol 38:177-87. 1994....
- The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45Taeko Nagata
Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, SOKENDAI, Shonan Village, Hayama 240 0193, Japan
Immunogenetics 54:286-91. 2002..It is likely that CD45 was recruited to activate lymphocytes through antigen receptors encoded by rearranging genes in jawed vertebrates...
- Macrophage migration inhibitory factor (MIF) of jawed and jawless fishes: implications for its evolutionary originAkie Sato
Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, Tubingen D 72076, Germany
Dev Comp Immunol 27:401-12. 2003..It also reveals a high degree of convergent evolution among the members of the family. Finally, it suggests that the divergence of MIF and DDT occurred before the emergence of nematodes in metazoan evolution...
- An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti)Sylvia Y Yao
Department of Physiology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada T6G 2H7
Am J Physiol Cell Physiol 283:C155-68. 2002..The high degree of sequence similarity between hfCNT and hCNT3 may indicate functional constraints on the primary structure of the transporter and suggests that cib-type CNTs fulfill important physiological functions...
- Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeriMegumi Mito
Division of Biophysical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka 560 8531 Osaka, Japan
J Biol Chem 277:21898-905. 2002..Our results therefore suggest that the formation of the alpha2beta2 tetramer using the BGH core and the mechanism of quaternary structure change evolved between the branching points of hagfish and lampreys from other vertebrates...
- Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2S K Loewen
Membrane Transport Research Group, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 274:24475-84. 1999..Helix modeling of hCNT1 placed Ser(319) (TM 7) and Ser(353) (TM 8) within the putative substrate translocation channel, whereas Gln(320) (TM 7) and Leu(354) (TM 8) may exert their effects through altered helix packing...
- Phosphoglucose isomerases of hagfish, zebrafish, gray mullet, toad, and snake, with reference to the evolution of the genes in vertebratesHsiao Wei Kao
Institute of Zoology, Academia Sinica, Taipei, Taiwan 115, ROC
Mol Biol Evol 19:367-74. 2002..The gene tree suggests that the gene duplication event of PGI in bonyfishes occurred before diversification of Acanthopterygii but after the split of bonyfishes and tetrapods. The evolution of multiple functions of PGI is discussed...
- Identification of a functional corpus luteum in the Atlantic hagfish, Myxine glutinosaMickie L Powell
Department of Biochemistry and Molecular Biology, University of New Hampshire, College of Life Sciences and Agriculture, 46 College Road, Durham, NH 03824 2617, USA
Gen Comp Endocrinol 148:95-101. 2006..From these results, we hypothesize that hagfish have functional corpora lutea like structures that produce progesterone...
- [Hagfish embryos and origin of vertebrates]Shigeru Kuratani
Tanpakushitsu Kakusan Koso 52:1878-83. 2007
- Eptatretus strickrotti n. sp. (Myxinidae): first hagfish captured from a hydrothermal ventPeter R Møller
Zoological Museum, Natural History Museum, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen East, Denmark
Biol Bull 212:55-66. 2007..Molecular 16S rRNA data places this new species as the basal-most species of Eptatretus, providing important new insight to the evolution of hagfishes as a whole.
- Hagfish embryos again: the end of a long droughtNicholas D Holland
Marine Biology Research Division, SIO, UCSD, La Jolla, CA 92093 0202, USA
Bioessays 29:833-6. 2007b>Hagfishes have long held a key place in discussions of early vertebrate evolution...
- [Chromatin diminution at the border of the XX and XXI centuries]A K Grishanin
Tsitologiia 48:379-97. 2006..Thus, a certain part of genome with a particular size and structure may serve for genetic isolation of species as shellfish or junk DNA are vital components rather than pieces of garbage...
- Q/R RNA editing of the AMPA receptor subunit 2 (GRIA2) transcript evolves no later than the appearance of cartilaginous fishesS S Kung
Department of Life Science, National Tsing-Hua University, 101, Sec 2, Kang Fu Road, 30043, Hsinchu, Taiwan, ROC
FEBS Lett 509:277-81. 2001..Results of this study suggest that modification of GRIA2 transcripts by Q/R editing is most likely acquired after the separation of the Agnatha and Gnathostome...
- Immunological detection of Na(+)/H(+) exchangers in the gills of a hagfish, Myxine glutinosa, an elasmobranch, Raja erinacea, and a teleost, Fundulus heteroclitusKeith P Choe
Department of Zoology, University of Florida, Gainesville, FL 32611, USA
Comp Biochem Physiol A Mol Integr Physiol 131:375-85. 2002..These data are some of the first direct evidence of NHEs in the gills of an agnathan and elasmobranch, and confirm the presence of NHEs in the gills of teleosts...
- Ribosomal RNA genes and deuterostome phylogeny revisited: more cyclostomes, elasmobranchs, reptiles, and a brittle starJon Mallatt
School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
Mol Phylogenet Evol 43:1005-22. 2007..bootstrapping, include: (1) brittle star joins with sea star in the echinoderm clade, Asterozoa; (2) with two hagfishes and two lampreys now available, the cyclostome (jawless) fishes remain monophyletic; (3) Hexanchiform sharks are ..
- Molecular cloning of proopiomelanocortin cDNA in the ratfish, a holocephalanAkiyoshi Takahashi
School of Fisheries Sciences, Kitasato University, Sanriku, Iwate 022 0101, Japan
Gen Comp Endocrinol 135:159-65. 2004..Thus, we demonstrated the common occurrence of four MSHs in chondrichthian POMC and established a clear understanding of the molecular evolution of POMC in gnathostomes...
- Taste buds: development and evolutionR Glenn Northcutt
Neurobiology Unit, Scripps Institution of Oceanography and Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, Calif 92093 0201, USA
Brain Behav Evol 64:198-206. 2004..All vertebrates, with the exception of hagfishes, have taste buds...
- Third component of trout complement. cDNA cloning and conservation of functional sitesJ D Lambris
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadephia 19104
J Immunol 151:6123-34. 1993..Protein sequencing of the trout C3 fragments fixed on zymosan during complement activation confirmed the cleavage of trout C3 by trout C3 convertase and factor I at Arg-Ser and Arg-Thr, respectively...
- Adaptive gene loss reflects differences in the visual ecology of basal vertebratesWayne L Davies
Department of Molecular Genetics, UCL Institute of Ophthalmology, London, UK
Mol Biol Evol 26:1803-9. 2009The agnathans (lampreys and hagfishes) are representatives of the jawless fishes and constitute the first lineage of extant vertebrates to evolve within chordate phylogenetic history...
- Development and organization of the lamprey telencephalon with special reference to the GABAergic systemManuel A Pombal
Neurolam Group, Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo Vigo, Spain
Front Neuroanat 5:20. 2011Lampreys, together with hagfishes, represent the sister group of gnathostome vertebrates...
- Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)M W Ritzel
Membrane Transport Research Group, Departments of Physiology, Oncology, and Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 276:2914-27. 2001..The hCNT3 gene mapped to chromosome 9q22.2 and included an upstream phorbol myristate acetate response element...
- Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fishM E Hahn
Department of Biology, Woods Hole Oceanographic Institution Woods Hole, MA 02543 1049, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:67-75. 1998..Agnathan fish such as hagfish and lamprey may be interesting model species for examining possible ancestral AHR functions not related to CYP1A regulation...
- Immunohistochemical localization of bioactive peptides and amines associated with the chromaffin tissue of five species of fishS G Reid
Department of Zoophysiology, University of Goteborg, Sweden
Cell Tissue Res 280:499-512. 1995..These results are compared with those of other vertebrates, and potential roles for these substances in the control of catecholamine release are suggested...
- Ammonia and urea excretion in the Pacific hagfish Eptatretus stoutii: Evidence for the involvement of Rh and UT proteinsMarvin H Braun
Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Canada ON K1N 6N5
Comp Biochem Physiol A Mol Integr Physiol 157:405-15. 2010....
- Cardiac natriuretic peptides: a physiological lineage of cardioprotective hormones?A P Farrell
Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
Physiol Biochem Zool 73:1-11. 2000..It is also likely that the cardioprotective role of NPs was one of the most primordial homeostatic activities of these peptides in the earliest vertebrates...
- The ancestral complement system in sea urchinsL C Smith
The Department of Biological Sciences, Institute of Biomedical Sciences, George Washington University, Washington, DC 20052, USA
Immunol Rev 180:16-34. 2001....
- Identification of two Ikaros-like transcription factors in lampreyW E Mayer
Max Planck Institut fur Biologie, Abt Immungenetik, Corrensstr 42, 72076 Tubingen, Germany
Scand J Immunol 55:162-70. 2002The jawless Agnatha (lampreys and hagfishes) represent the phylogenetically oldest order of vertebrates that are believed to lack the adaptive immune system of jawed vertebrates...
- The sympathetic nervous system of anamniotesKengo Funakoshi
Department of Neuroanatomy, Yokohama City University School of Medicine, Yokohama, Japan
Brain Behav Evol 69:105-13. 2007..e., hagfishes and lampreys)...
- Morphology and spectral absorption characteristics of retinal photoreceptors in the southern hemisphere lamprey (Geotria australis)Shaun P Collin
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Queensland, Australia
Vis Neurosci 20:119-30. 2003..Our results provide the first evidence of a jawless vertebrate, represented today solely by the lampreys and hagfishes, with two morphologically and physiologically distinct types of cone photoreceptors, in addition to a rod-like ..
- A comparative study on innate immune parameters in the epidermal mucus of various fish speciesSangeetha Subramanian
National Research Council Institute for Marine Biosciences, Nova Scotia, Canada B3H 3Z1
Comp Biochem Physiol B Biochem Mol Biol 148:256-63. 2007..These results provide preliminary information for a better understanding of the role of epidermal mucus and its components in the fish innate immune system...
- Expression and interaction of muscle-related genes in the lamprey imply the evolutionary scenario for vertebrate skeletal muscle, in association with the acquisition of the neck and finsRie Kusakabe
Department of Biology, Graduate School of Science, Kobe University, Japan
Dev Biol 350:217-27. 2011....
- Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7Anurag Purushothaman
Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
J Biol Chem 282:19442-52. 2007..Four discrete decasaccharide epitopic sequences were identified. The antibody GD3G7 has broad applications in investigations of CS/DS chains during the central nervous system's development and under various pathological conditions...
- Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomesJ J Smith
Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101, USA
Integr Comp Biol 50:130-7. 2010..Validating this premise will require better characterization of the genome sequence and mechanisms of rearrangement in lamprey and hagfish...
- The heart as a working model to explore themes and strategies for anoxic survival in ectothermic vertebratesA P Farrell
Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Comp Biochem Physiol A Mol Integr Physiol 147:300-12. 2007..Here, we summarize in vitro measurements of PO data from rainbow trout, freshwater turtles and hagfishes to provide a reasonable benchmark PO of 0...
- [Progress of adaptive immunity system of agnathan vertebrates]Jiao Liang
Institute of Marine Genomics lt Proteomics, Liaoning Normal University, Dalian 116029, China
Yi Chuan 31:969-76. 2009Extant jawless vertebrates, represented by lampreys and hagfishes, have innate immune receptors with variable domains structurally resembling T/B-cell receptors...
- Go reconfigure: how fish change shape as they swim and evolveJohn H Long
Department of Biology and Program in Cognitive Science, Vassar College, Poughkeepsie, NY 12604, USA
Integr Comp Biol 50:1120-39. 2010....
- Update: brain and pituitary hormones of lampreysS A Sower
Department of Biochemistry and Molecular Biology, University of New Hampshire, 03824, Durham, NH, USA
Comp Biochem Physiol B Biochem Mol Biol 129:291-302. 2001....
- Early evolution of multifocal optics for well-focused colour vision in vertebratesO S E Gustafsson
Department of Cell and Organism Biology, Lund University, Helgonavagen 3, 223 62 Lund, Sweden
J Exp Biol 211:1559-64. 2008Jawless fishes (Agnatha; lampreys and hagfishes) most closely resemble the earliest stage in vertebrate evolution and lamprey-like animals already existed in the Lower Cambrian [about 540 million years ago (MYA)]...
- Cyclostome and chondrichthyan adrenomedullins reveal ancestral features of the adrenomedullin familyMarty K S Wong
Hadal Environmental Science Education Program, Ocean Research Institute, The University of Tokyo, Nakano Ku, Tokyo 164 8639, Japan
Comp Biochem Physiol B Biochem Mol Biol 154:317-25. 2009....
- Developmental anatomy of lampreysMichael K Richardson
Institute of Biology, Leiden University, Kaiserstraat 63, 2311GP Leiden, The Netherlands
Biol Rev Camb Philos Soc 85:1-33. 2010Lampreys are a group of aquatic chordates whose relationships to hagfishes and jawed vertebrates are still debated. Lamprey embryology is of interest to evolutionary biologists because it may shed light on vertebrate origins...
- IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYHarry Schroeder; Fiscal Year: 2007....
- HEAT SHOCK PROTEIN GP96 AND IMMUNITYNicholas Cohen; Fiscal Year: 2003..Experiments to evaluate the specificity and peptide complex-dependency of these putative alloimmune reactivities are presented as are experiments to reveal the nature of effector cells involved. ..
- Characterization of the Lamprey Adaptive Immune SystemMax Cooper; Fiscal Year: 2009..The experiments proposed here will define biological and structural features of the VLRs in order to explore their potential for health-related uses. ..
- Characterization of the Lamprey Adaptive Immune SystemMAX DALE COOPER; Fiscal Year: 2010..The experiments proposed here will define biological and structural features of the VLRs in order to explore their potential for health-related uses. ..
- Characterization of the Lamprey Adaptive Immune SystemMax Cooper; Fiscal Year: 2007..The experiments proposed here will define biological and structural features of the VLRs in order to explore their potential for health-related uses. ..
- Evolution of Steroid Receptor-Hormone InteractionsJAMIE BRIDGHAM; Fiscal Year: 2006..These sites are predicted to provide ideal targets for therapeutic interventions for heart and kidney disease. ..
- Developmental and genomic studies on the agnatha VLR systemChris Amemiya; Fiscal Year: 2007....
- STRUCTURE AND DIVERSITY IN THE IMMUNE SYSTEMLisa Steiner; Fiscal Year: 1993..We will, therefore, determine whether RAG-1 is present in representative Agnatha (hagfish and lamprey); its identification would justify renewed efforts to characterize the immune system of these primitive vertebrates...
- Identification of GCK-3 signaling pathways in C. elegansKEITH CHOE; Fiscal Year: 2007..I will use a combination of molecular biology, forward and reverse genetic analyses, and patch clamp electrophysiology to identify GCK-3 signaling components. ..
- Mechanisms of Embryo Response to Oxidative StressMark E Hahn; Fiscal Year: 2010....
- Isotype Exclusion and Hypermutation in the Nurse SharkEllen Hsu; Fiscal Year: 2007..abstract_text> ..
- Characterization of the flexible portions of fibrinogenRussell Doolittle; Fiscal Year: 2007..These studies are aimed at determining the degree of specificity involved in the assembly of fibrin units and protofibrils as well as the relative locations of the regions involved. ..
- AHR signaling in Mammalian and Non-Mammalian ModelsMARK HAHN; Fiscal Year: 2007..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
- Immunoglobulin Constant Region Switch and Hypermutation in the Nurse SharkEllen Hsu; Fiscal Year: 2009..Studying these phenomena will help determine parameters for genetic exchange between non-allelic genes and give insight into the origins of somatic translocation events leading to disease states. ..
- Comparison of B Cell Differentiation in Mice and HumansMax Cooper; Fiscal Year: 2007..This comparative analysis will define novel features of B cell differentiationthat are likely to have significant clinical implications. ..
- Insight from Lamprey Genome: Structure-Function studies of Novel GnRH ReceptorsSTACIA SOWER; Fiscal Year: 2007..Studying the lamprey genome is a touchstone for understanding genes that arose in the vertebrates and offers an innovative approach to therapeutic research. ..
- MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICECaroline Zeiss; Fiscal Year: 2007..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
- AHR signaling in Mammalian and Non-Mammalian ModelsMark E Hahn; Fiscal Year: 2010....
- TASTE BUD DEVELOPMENTRICHARD NORTHCUTT; Fiscal Year: 1993..Additional experimental neuroanatomical studies on the organization of the gustatory system of juvenile and adult axolotls will also be conducted in order to provide a more complete picture of this system...
- DEVELOPMENT OF THE GUSTATORY SYSTEMRICHARD NORTHCUTT; Fiscal Year: 2000..These experiments should begin to unravel the complex interactions of the tissues that form the vertebrate head, and they are a necessary preamble to identifying the molecular signals underlying the development of the gustatory system. ..
- DEVELOPMENT OF THE GUSTATORY SYSTEMRICHARD NORTHCUTT; Fiscal Year: 2005..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
- STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRINRussell Doolittle; Fiscal Year: 2003..Combined with the full structures of the native molecules at high resolution, these results should dispel much of the mystery of fibrin formation. ..